ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0044183 protein folding chaperone 4/33 75/18639 0.0533333333333333 30.1236363636364 9.05589381312018e-06 0.00135838407196803 GO:0004867 serine-type endopeptidase inhibitor activity 4/33 95/18639 0.0421052631578947 23.7818181818182 2.313619216657e-05 0.00173521441249275 GO:0140662 ATP-dependent protein folding chaperone 3/33 40/18639 0.075 42.3613636363636 4.77733393524309e-05 0.00224151767690242 GO:0051082 unfolded protein binding 4/33 121/18639 0.0330578512396694 18.671675432006 5.97738047173978e-05 0.00224151767690242 GO:0031072 heat shock protein binding 4/33 131/18639 0.0305343511450382 17.2463566967384 8.14188708875459e-05 0.00244256612662638 GO:0004866 endopeptidase inhibitor activity 4/33 161/18639 0.0248447204968944 14.0327498588368 0.000180509650877078 0.00429011986523957 GO:0030414 peptidase inhibitor activity 4/33 169/18639 0.0236686390532544 13.36847767617 0.000217369697239626 0.00429011986523957 GO:0044548 S100 protein binding 2/33 14/18639 0.142857142857143 80.6883116883117 0.000272963282821799 0.00429011986523957 GO:0045296 cadherin binding 5/33 334/18639 0.0149700598802395 8.4553620032662 0.000281754807576103 0.00429011986523957 GO:0061135 endopeptidase regulator activity 4/33 184/18639 0.0217391304347826 12.2786561264822 0.000300673249235216 0.00429011986523957 GO:0140776 protein-containing complex destabilizing activity 2/33 15/18639 0.133333333333333 75.3090909090909 0.000314608790117569 0.00429011986523957 GO:0048306 calcium-dependent protein binding 3/33 80/18639 0.0375 21.1806818181818 0.000378572157075537 0.00473215196344422 GO:0098641 cadherin binding involved in cell-cell adhesion 2/33 18/18639 0.111111111111111 62.7575757575758 0.000456908682621836 0.00527202326102119 GO:0061134 peptidase regulator activity 4/33 226/18639 0.0176991150442478 9.99678197908286 0.000653491717220608 0.0070016969702208 GO:0004857 enzyme inhibitor activity 5/33 416/18639 0.0120192307692308 6.78868006993007 0.000766380041009825 0.00766380041009825 GO:0097718 disordered domain specific binding 2/33 28/18639 0.0714285714285714 40.3441558441558 0.00111640297889089 0.0104662779271021 GO:0042826 histone deacetylase binding 3/33 127/18639 0.0236220472440945 13.3421617752326 0.00145164259991281 0.0114531096242119 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 5/33 484/18639 0.0103305785123967 5.83489857250188 0.00150509347654155 0.0114531096242119 GO:0019956 chemokine binding 2/33 33/18639 0.0606060606060606 34.2314049586777 0.00155081687163147 0.0114531096242119 GO:0140416 transcription regulator inhibitor activity 2/33 33/18639 0.0606060606060606 34.2314049586777 0.00155081687163147 0.0114531096242119 GO:0001216 DNA-binding transcription activator activity 5/33 491/18639 0.010183299389002 5.75171264580633 0.00160343534738967 0.0114531096242119 GO:0031625 ubiquitin protein ligase binding 4/33 302/18639 0.0132450331125828 7.48103552077062 0.00190876819629708 0.0130143286111164 GO:0044389 ubiquitin-like protein ligase binding 4/33 322/18639 0.0124223602484472 7.01637492941841 0.00240937360369939 0.015713306111083 GO:0005201 extracellular matrix structural constituent 3/33 168/18639 0.0178571428571429 10.086038961039 0.00321753293858953 0.0201095808661846 GO:0098632 cell-cell adhesion mediator activity 2/33 55/18639 0.0363636363636364 20.5388429752066 0.00425692530348169 0.0255415518208901 GO:0001786 phosphatidylserine binding 2/33 59/18639 0.0338983050847458 19.1463790446841 0.00488317918341116 0.0281721875966028 GO:0051015 actin filament binding 3/33 209/18639 0.0143540669856459 8.10743801652893 0.00591863176241646 0.0328812875689803 GO:0097110 scaffold protein binding 2/33 70/18639 0.0285714285714286 16.1376623376623 0.0068092971649368 0.0364783776693043 GO:0098631 cell adhesion mediator activity 2/33 76/18639 0.0263157894736842 14.8636363636364 0.00798287523240096 0.0412907339606946 GO:0001618 virus receptor activity 2/33 81/18639 0.0246913580246914 13.9461279461279 0.00902544501141038 0.0447140522810814 GO:0140272 exogenous protein binding 2/33 82/18639 0.024390243902439 13.7760532150776 0.00924090413809017 0.0447140522810814 GO:0072341 modified amino acid binding 2/33 91/18639 0.021978021978022 12.4135864135864 0.0112823483618254 0.0528860079460565 GO:0001664 G protein-coupled receptor binding 3/33 297/18639 0.0101010101010101 5.70523415977961 0.0153542280038704 0.0697919454721383 GO:0043121 neurotrophin binding 1/33 10/18639 0.1 56.4818181818182 0.0175686274801516 0.0753866844443864 GO:0001221 transcription coregulator binding 2/33 115/18639 0.0173913043478261 9.82292490118577 0.0175902263703568 0.0753866844443864 GO:0004859 phospholipase inhibitor activity 1/33 12/18639 0.0833333333333333 47.0681818181818 0.0210462579313941 0.0853226672894357 GO:0031543 peptidyl-proline dioxygenase activity 1/33 12/18639 0.0833333333333333 47.0681818181818 0.0210462579313941 0.0853226672894357 GO:0002020 protease binding 2/33 136/18639 0.0147058823529412 8.30614973262032 0.0240740534740973 0.0950291584503841 GO:0005523 tropomyosin binding 1/33 15/18639 0.0666666666666667 37.6545454545454 0.0262403314625587 0.0979223497467681 GO:0050780 dopamine receptor binding 1/33 15/18639 0.0666666666666667 37.6545454545454 0.0262403314625587 0.0979223497467681 GO:0019955 cytokine binding 2/33 144/18639 0.0138888888888889 7.84469696969697 0.0267654422641166 0.0979223497467681 GO:0055102 lipase inhibitor activity 1/33 16/18639 0.0625 35.3011363636364 0.0279657432463719 0.0998776544513283 GO:0051787 misfolded protein binding 1/33 17/18639 0.0588235294117647 33.2245989304813 0.0296881902459354 0.103563454346286 GO:0031418 L-ascorbic acid binding 1/33 20/18639 0.05 28.2409090909091 0.0348377918540772 0.11793776573039 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 1/33 21/18639 0.0476190476190476 26.8961038961039 0.036548428991883 0.11793776573039 GO:0070182 DNA polymerase binding 1/33 21/18639 0.0476190476190476 26.8961038961039 0.036548428991883 0.11793776573039 GO:0016887 ATP hydrolysis activity 3/33 417/18639 0.00719424460431655 4.06344015696534 0.0369538332621888 0.11793776573039 GO:0030021 extracellular matrix structural constituent conferring compression resistance 1/33 22/18639 0.0454545454545455 25.6735537190083 0.0382561259433963 0.119550393573114 GO:0005540 hyaluronic acid binding 1/33 24/18639 0.0416666666666667 23.5340909090909 0.0416627188629953 0.124988156588986 GO:0019957 C-C chemokine binding 1/33 24/18639 0.0416666666666667 23.5340909090909 0.0416627188629953 0.124988156588986 GO:0003779 actin binding 3/33 443/18639 0.00677200902934537 3.82495382721116 0.0429803712791561 0.1264128567034 GO:0004435 phosphatidylinositol phospholipase C activity 1/33 26/18639 0.0384615384615385 21.7237762237762 0.0450576096849579 0.127501851777085 GO:0070412 R-SMAD binding 1/33 26/18639 0.0384615384615385 21.7237762237762 0.0450576096849579 0.127501851777085 GO:0001671 ATPase activator activity 1/33 27/18639 0.037037037037037 20.9191919191919 0.046750678984931 0.127501851777085 GO:0023026 MHC class II protein complex binding 1/33 27/18639 0.037037037037037 20.9191919191919 0.046750678984931 0.127501851777085 GO:0004629 phospholipase C activity 1/33 29/18639 0.0344827586206897 19.4764890282132 0.0501280896454219 0.129531101738715 GO:0043236 laminin binding 1/33 29/18639 0.0344827586206897 19.4764890282132 0.0501280896454219 0.129531101738715 GO:0003714 transcription corepressor activity 2/33 204/18639 0.00980392156862745 5.53743315508021 0.0504199667058223 0.129531101738715 GO:0031624 ubiquitin conjugating enzyme binding 1/33 30/18639 0.0333333333333333 18.8272727272727 0.0518124406954862 0.129531101738715 GO:0035925 mRNA 3'-UTR AU-rich region binding 1/33 30/18639 0.0333333333333333 18.8272727272727 0.0518124406954862 0.129531101738715 GO:0071889 14-3-3 protein binding 1/33 33/18639 0.0303030303030303 17.1157024793388 0.0568481346983507 0.139790495159879 GO:0061631 ubiquitin conjugating enzyme activity 1/33 35/18639 0.0285714285714286 16.1376623376623 0.0601908462330047 0.14562301507985 GO:0044390 ubiquitin-like protein conjugating enzyme binding 1/33 36/18639 0.0277777777777778 15.6893939393939 0.0618578910660681 0.147280693014448 GO:0023023 MHC protein complex binding 1/33 37/18639 0.027027027027027 15.2653562653563 0.0635220683275216 0.148879847642629 GO:0061650 ubiquitin-like protein conjugating enzyme activity 1/33 41/18639 0.024390243902439 13.7760532150776 0.0701501971171434 0.158382591282717 GO:0008307 structural constituent of muscle 1/33 42/18639 0.0238095238095238 13.4480519480519 0.0718001080481648 0.158382591282717 GO:0019894 kinesin binding 1/33 42/18639 0.0238095238095238 13.4480519480519 0.0718001080481648 0.158382591282717 GO:0035198 miRNA binding 1/33 42/18639 0.0238095238095238 13.4480519480519 0.0718001080481648 0.158382591282717 GO:0048156 tau protein binding 1/33 43/18639 0.0232558139534884 13.1353065539112 0.0734471799648402 0.159667782532261 GO:0001046 core promoter sequence-specific DNA binding 1/33 44/18639 0.0227272727272727 12.8367768595041 0.0750914175998774 0.160910180571166 GO:0001784 phosphotyrosine residue binding 1/33 47/18639 0.0212765957446809 12.0174081237911 0.080007172027788 0.169029236678425 GO:0060590 ATPase regulator activity 1/33 49/18639 0.0204081632653061 11.5269016697588 0.0832702566614784 0.17347970137808 GO:0005010 insulin-like growth factor receptor activity 1/33 51/18639 0.0196078431372549 11.0748663101604 0.0865221171063415 0.173968124905305 GO:0030544 Hsp70 protein binding 1/33 51/18639 0.0196078431372549 11.0748663101604 0.0865221171063415 0.173968124905305 GO:0030246 carbohydrate binding 2/33 280/18639 0.00714285714285714 4.03441558441558 0.0876070497567268 0.173968124905305 GO:0005080 protein kinase C binding 1/33 52/18639 0.0192307692307692 10.8618881118881 0.0881438499520213 0.173968124905305 GO:0005544 calcium-dependent phospholipid binding 1/33 53/18639 0.0188679245283019 10.6569468267581 0.0897627907682683 0.174862579418705 GO:0004601 peroxidase activity 1/33 57/18639 0.0175438596491228 9.90909090909091 0.0962107267639952 0.180388553376351 GO:0061980 regulatory RNA binding 1/33 58/18639 0.0172413793103448 9.73824451410658 0.0978157771362258 0.180388553376351 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 1/33 59/18639 0.0169491525423729 9.57318952234206 0.0994180633078265 0.180388553376351 GO:0045309 protein phosphorylated amino acid binding 1/33 59/18639 0.0169491525423729 9.57318952234206 0.0994180633078265 0.180388553376351 GO:0070063 RNA polymerase binding 1/33 59/18639 0.0169491525423729 9.57318952234206 0.0994180633078265 0.180388553376351 GO:0004714 transmembrane receptor protein tyrosine kinase activity 1/33 60/18639 0.0166666666666667 9.41363636363636 0.101017589890757 0.180388553376351 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 1/33 60/18639 0.0166666666666667 9.41363636363636 0.101017589890757 0.180388553376351 GO:0051020 GTPase binding 2/33 315/18639 0.00634920634920635 3.58614718614719 0.106827235243118 0.188518650429031 GO:0050840 extracellular matrix binding 1/33 67/18639 0.0149253731343284 8.43012211668928 0.1121373933322 0.19558847674221 GO:1990841 promoter-specific chromatin binding 1/33 68/18639 0.0147058823529412 8.30614973262032 0.113715008345125 0.196060359215733 GO:0002039 p53 binding 1/33 69/18639 0.0144927536231884 8.18577075098814 0.115289904943295 0.196516883426071 GO:0048029 monosaccharide binding 1/33 74/18639 0.0135135135135135 7.63267813267813 0.123123770286826 0.207511972393528 GO:0019199 transmembrane receptor protein kinase activity 1/33 78/18639 0.0128205128205128 7.24125874125874 0.129342392020463 0.215570653367438 GO:0046332 SMAD binding 1/33 79/18639 0.0126582278481013 7.14959723820483 0.130890352855726 0.215753328883065 GO:0030165 PDZ domain binding 1/33 83/18639 0.0120481927710843 6.80503833515882 0.13705555176074 0.218826651495688 GO:0046982 protein heterodimerization activity 2/33 369/18639 0.00542005420054201 3.06134515890613 0.138435433398319 0.218826651495688 GO:0004860 protein kinase inhibitor activity 1/33 84/18639 0.0119047619047619 6.72402597402597 0.138590212613936 0.218826651495688 GO:0051117 ATPase binding 1/33 84/18639 0.0119047619047619 6.72402597402597 0.138590212613936 0.218826651495688 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 1/33 86/18639 0.0116279069767442 6.5676532769556 0.141651598702413 0.219048863972803 GO:0016209 antioxidant activity 1/33 86/18639 0.0116279069767442 6.5676532769556 0.141651598702413 0.219048863972803 GO:0008081 phosphoric diester hydrolase activity 1/33 87/18639 0.0114942528735632 6.49216300940439 0.143178332774682 0.219150509349004 GO:0019210 kinase inhibitor activity 1/33 90/18639 0.0111111111111111 6.27575757575758 0.147742751975626 0.223852654508524 GO:0051213 dioxygenase activity 1/33 93/18639 0.010752688172043 6.0733137829912 0.152283588842508 0.226163745805706 GO:0051219 phosphoprotein binding 1/33 93/18639 0.010752688172043 6.0733137829912 0.152283588842508 0.226163745805706 GO:0008170 N-methyltransferase activity 1/33 98/18639 0.0102040816326531 5.76345083487941 0.159799565474038 0.234999360991233 GO:0004620 phospholipase activity 1/33 109/18639 0.00917431192660551 5.18181818181818 0.176107954158884 0.256467894406142 GO:1902936 phosphatidylinositol bisphosphate binding 1/33 111/18639 0.00900900900900901 5.08845208845209 0.179039951999254 0.257860220224694 GO:0005200 structural constituent of cytoskeleton 1/33 112/18639 0.00892857142857143 5.04301948051948 0.180502154157286 0.257860220224694 GO:1990782 protein tyrosine kinase binding 1/33 117/18639 0.00854700854700855 4.82750582750583 0.187775366435854 0.264102416435354 GO:0004842 ubiquitin-protein transferase activity 2/33 449/18639 0.0044543429844098 2.51589390564892 0.188393057057219 0.264102416435354 GO:0004519 endonuclease activity 1/33 127/18639 0.0078740157480315 4.44738725841088 0.202134477257815 0.280742329524743 GO:0016298 lipase activity 1/33 130/18639 0.00769230769230769 4.34475524475524 0.206393996223411 0.282607346895972 GO:0019787 ubiquitin-like protein transferase activity 2/33 479/18639 0.00417536534446764 2.35832226228886 0.207772596082934 0.282607346895972 GO:0051087 protein-folding chaperone binding 1/33 134/18639 0.00746268656716418 4.21506105834464 0.212039066941081 0.282607346895972 GO:0019838 growth factor binding 1/33 136/18639 0.00735294117647059 4.15307486631016 0.214846981215212 0.282607346895972 GO:0044325 transmembrane transporter binding 1/33 136/18639 0.00735294117647059 4.15307486631016 0.214846981215212 0.282607346895972 GO:0003712 transcription coregulator activity 2/33 495/18639 0.00404040404040404 2.28209366391185 0.21820458848493 0.282607346895972 GO:0016755 aminoacyltransferase activity 2/33 496/18639 0.00403225806451613 2.2774926686217 0.218858437979 0.282607346895972 GO:0005543 phospholipid binding 2/33 497/18639 0.00402414486921529 2.27291018840315 0.219512488925565 0.282607346895972 GO:0004713 protein tyrosine kinase activity 1/33 140/18639 0.00714285714285714 4.03441558441558 0.220433730578858 0.282607346895972 GO:0020037 heme binding 1/33 142/18639 0.00704225352112676 3.97759282970551 0.223212630545624 0.283744869337657 GO:0019903 protein phosphatase binding 1/33 144/18639 0.00694444444444444 3.92234848484848 0.225981923778694 0.284851164426925 GO:0019842 vitamin binding 1/33 150/18639 0.00666666666666667 3.76545454545455 0.234232484318375 0.292790605397969 GO:0046906 tetrapyrrole binding 1/33 152/18639 0.00657894736842105 3.71590909090909 0.236963671339088 0.293756617362505 GO:0005506 iron ion binding 1/33 154/18639 0.00649350649350649 3.66765053128689 0.239685411468239 0.29469517803472 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 1/33 167/18639 0.00598802395209581 3.38214480130648 0.25714863099152 0.313595891453073 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 1/33 181/18639 0.00552486187845304 3.12054244098443 0.27552013671559 0.333290487962407 GO:1901981 phosphatidylinositol phosphate binding 1/33 185/18639 0.00540540540540541 3.05307125307125 0.280687701874557 0.336441694989667 GO:0031406 carboxylic acid binding 1/33 187/18639 0.0053475935828877 3.02041808458921 0.283258063204058 0.336441694989667 GO:0043177 organic acid binding 1/33 189/18639 0.00529100529100529 2.98845598845599 0.285819517072124 0.336441694989667 GO:0019902 phosphatase binding 1/33 190/18639 0.00526315789473684 2.97272727272727 0.287096913057849 0.336441694989667 GO:0008168 methyltransferase activity 1/33 204/18639 0.00490196078431373 2.76871657754011 0.304749498599055 0.354359882091924 GO:0005516 calmodulin binding 1/33 207/18639 0.00483091787439614 2.72859025032938 0.308476668840686 0.3559346178931 GO:0004518 nuclease activity 1/33 209/18639 0.00478468899521531 2.70247933884297 0.310950677042877 0.356050393560546 GO:0016741 transferase activity, transferring one-carbon groups 1/33 215/18639 0.00465116279069767 2.62706131078224 0.318321314295134 0.361728766244471 GO:0005085 guanyl-nucleotide exchange factor activity 1/33 230/18639 0.00434782608695652 2.45573122529644 0.336414996136254 0.379415409176226 GO:0005539 glycosaminoglycan binding 1/33 242/18639 0.00413223140495868 2.33395942900075 0.350553801184735 0.39241097147545 GO:0019887 protein kinase regulator activity 1/33 255/18639 0.00392156862745098 2.21497326203209 0.365541159044625 0.406156843382917 GO:0003730 mRNA 3'-UTR binding 1/33 262/18639 0.00381679389312977 2.1557945870923 0.373471792858041 0.411917418593427 GO:0005126 cytokine receptor binding 1/33 275/18639 0.00363636363636364 2.05388429752066 0.387945840425131 0.424758219443574 GO:0031267 small GTPase binding 1/33 283/18639 0.00353356890459364 1.99582396402184 0.396691216858322 0.429254494629108 GO:0035091 phosphatidylinositol binding 1/33 284/18639 0.00352112676056338 1.98879641485275 0.39777583168964 0.429254494629108 GO:0019207 kinase regulator activity 1/33 287/18639 0.00348432055749129 1.96800760215394 0.401018343486363 0.429662510878247 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 1/33 349/18639 0.00286532951289398 1.61839020578276 0.464362247694198 0.494002391164041 GO:0061630 ubiquitin protein ligase activity 1/33 353/18639 0.0028328611898017 1.60005150656709 0.468217842433508 0.494596312429762 GO:0042578 phosphoric ester hydrolase activity 1/33 363/18639 0.00275482093663912 1.55597295266717 0.477739461141919 0.501125308890125 GO:0061659 ubiquitin-like protein ligase activity 1/33 372/18639 0.00268817204301075 1.5183284457478 0.486167413295478 0.506424388849456 GO:0005525 GTP binding 1/33 378/18639 0.00264550264550265 1.49422799422799 0.491712618934331 0.508668226483791 GO:0019001 guanyl nucleotide binding 1/33 400/18639 0.0025 1.41204545454545 0.511552861459341 0.521992715774837 GO:0032561 guanyl ribonucleotide binding 1/33 400/18639 0.0025 1.41204545454545 0.511552861459341 0.521992715774837 GO:0140297 DNA-binding transcription factor binding 1/33 488/18639 0.00204918032786885 1.15741430700447 0.583666701565936 0.585179222896351 GO:0030695 GTPase regulator activity 1/33 489/18639 0.00204498977505112 1.15504740658115 0.584423629495434 0.585179222896351 GO:0060589 nucleoside-triphosphatase regulator activity 1/33 490/18639 0.00204081632653061 1.15269016697588 0.585179222896351 0.585179222896351