category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	11/104	238/9376	4.16677440206852	PIK3R1/C3/STAT3/IL6ST/JUN/TNFRSF1A/NRP1/RPL35/RPLP0/IRF9/RPL36A	5.24077631627199
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	10/104	205/9376	4.39774859287054	PIK3R1/C3/STAT3/IL6ST/JUN/CHD4/CREBBP/RBPJ/ATF2/IRF9	5.2092526516096
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	9/104	196/9376	4.13971742543171	PIK3R1/C3/STAT3/IL6ST/JUN/TNFRSF1A/CREBBP/TCF7L2/IRF9	4.70449330452943
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	5/104	63/9376	7.15506715506715	ASH1L/KMT2E/NSD1/SETD2/NSD3	5.1912729644893
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	9/104	217/9376	3.73909961006735	PIK3R1/STAT3/JUN/HSP90AB1/KPNB1/PGR/ATF2/AR/EPHX2	4.32343824383587
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	5/104	68/9376	6.6289592760181	PIK3R1/STAT3/PIM1/RUNX1T1/TCF7L2	4.9336685772373
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	7/104	184/9376	3.42976588628763	PIK3R1/NRP1/SEMA4B/PAK2/ROCK1/LRRC4C/EPHA5	3.52520137093884
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	4/104	62/9376	5.81637717121588	TLE4/CREBBP/RBPJ/ATXN1	4.02961740389855
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	5/104	106/9376	4.25253991291727	PIK3R1/HSP90AB1/CREBBP/TCF7L2/AR	3.56657447039451
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	7/104	200/9376	3.15538461538462	JUN/ACTB/TNFRSF1A/TUBB2B/PAK2/ROCK1/MYO1E	3.2630871303954
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	5/104	109/9376	4.13549752999294	STAT3/IL6ST/JUN/HSP90AB1/RORA	3.48711063852257
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	4/104	70/9376	5.15164835164835	PIK3R1/JUN/CREBBP/PAK2	3.69235673536614
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	9/104	323/9376	2.51202667301739	PIK3R1/SOX4/STAT3/MARCKS/PIM1/CREBBP/ROCK1/TNXB/ZEB2	2.92873481447119
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	6/104	168/9376	3.21978021978022	PIK3R1/STAT3/IL6ST/PIM1/CREBBP/IRF9	3.07466326475489
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	5/104	122/9376	3.69482976040353	PIK3R1/STAT3/IGFBP3/CREBBP/ATF2	3.17294174805152
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	7/104	224/9376	2.81730769230769	PIK3R1/JUN/TNFRSF1A/NRP1/CREBBP/ATF2/GPS2	2.91547998759891
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	8/104	300/9376	2.40410256410256	JUND/JUN/TNFRSF1A/IGF2/MAP4K4/PAK2/ATF2/MAP3K20	2.61774785596834
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	5/104	139/9376	3.24294410625346	PIK3R1/JUN/HSP90AB1/PGR/ATF2	2.82147350160727
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	4/104	93/9376	3.87758478081059	ACTB/CREBBP/ROCK1/TCF7L2	2.95352753008238
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	5/104	142/9376	3.17443120260022	JUND/PIK3R1/JUN/TNFRSF1A/IRF9	2.76509785250045
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	5/104	142/9376	3.17443120260022	PIK3R1/JUN/HSP90AB1/ACTB/TNFRSF1A	2.76509785250045
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	6/104	203/9376	2.66464569912846	PIK3R1/JUN/ACTB/PAK2/ROCK1/TNXB	2.53939190964997
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	4/104	101/9376	3.57044935262757	PIK3R1/STAT3/JUN/PIM1	2.7506059315883
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	6/104	204/9376	2.65158371040724	PIK3R1/STAT3/ACTB/IGF2/ROCK1/EIF4B	2.5258016802845
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	4/104	103/9376	3.50112023898432	PIK3R1/C3/JUN/TNFRSF1A	2.70307844491107
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	8/104	333/9376	2.16585816585817	PIK3R1/TNFRSF1A/CHD4/CREBBP/TNXB/RBPJ/TCF7L2/IRF9	2.29417829498259
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	5/104	163/9376	2.76545540349221	PIK3R1/STAT3/JUN/CREBBP/ATF2	2.40805063345776
NA	NA	hsa04519	Cadherin signaling	9/104	404/9376	2.00837776085301	TEAD1/CDH11/ACTB/FAT4/CREBBP/ROCK1/TCF7L2/PCDHGA10/MYO1E	2.19424392927521
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	3/104	66/9376	4.0979020979021	STAT3/JUN/RORA	2.67473285519232
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	6/104	227/9376	2.382921043714	PIK3R1/JUN/PRKD3/MT-ND6/MT-ND4L/EPHX2	2.23377330450583
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/104	29/9376	6.21750663129974	TEAD1/FAT4	2.98017305453614
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	4/104	119/9376	3.03038138332256	PIK3R1/JUN/TNFRSF1A/ATF2	2.36064981734178
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	5/104	173/9376	2.60560248999555	PIK3R1/ACTB/TNFRSF1A/CREBBP/IRF9	2.25741792854158
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	5/104	178/9376	2.5324114088159	JUN/TLE4/CREBBP/SFRP1/TCF7L2	2.18602070742572
NA	NA	hsa04517	IgSF CAM signaling	7/104	299/9376	2.11062516079238	PIK3R1/ACTB/NLGN1/NRP1/TUBB2B/PAK2/LRRC4C	2.06703357437974
Organismal Systems	Immune system	hsa04611	Platelet activation	4/104	126/9376	2.86202686202686	PIK3R1/ACTB/ROCK1/STIM1	2.22851696449112
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/104	34/9376	5.30316742081448	RORB/RORA	2.66209387791577
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	3/104	78/9376	3.46745562130178	C3/SERPING1/JUN	2.31748790990654
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	6/104	248/9376	2.18114143920596	JUN/HSP90AB1/ACTB/TNFRSF1A/TUBB2B/TCF7L2	1.99643662122572
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	6/104	253/9376	2.13803587716631	PIK3R1/C3/JUN/ACTB/TNFRSF1A/ROCK1	1.94340346695755
Human Diseases	Infectious disease: viral	hsa05162	Measles	4/104	136/9376	2.65158371040724	PIK3R1/STAT3/JUN/IRF9	2.05470584194217
Cellular Processes	Cell motility	hsa04814	Motor proteins	5/104	194/9376	2.32355273592387	ACTB/TUBB2B/TPM4/STARD9/MYO1E	1.97282729165984
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	4/104	137/9376	2.63222908478383	PIK3R1/JUN/ACTB/TNFRSF1A	2.03818925956147
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	4/104	138/9376	2.61315496098105	PIK3R1/JUN/ACTB/ROCK1	2.02181888450567
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	3/104	86/9376	3.14490161001789	PIK3R1/JUN/PAK2	2.11623718002958
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	3/104	86/9376	3.14490161001789	ACTB/SNTB1/TCF7L2	2.11623718002958
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	3/104	87/9376	3.10875331564987	PIK3R1/JUN/TCF7L2	2.09274599607505
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	5/104	201/9376	2.24263298890165	HOXA11/JMJD1C/IGFBP3/RUNX1T1/PBX1	1.88605115357654
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	4/104	144/9376	2.5042735042735	PIK3R1/RBPJ/RORA/ATXN1	1.92652988612375
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	5/104	205/9376	2.19887429643527	PIK3R1/STAT3/JUN/RBPJ/IRF9	1.83805215040228
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	3/104	90/9376	3.0051282051282	PIK3R1/STAT3/JUN	2.02425237483718
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	4/104	148/9376	2.43659043659044	PIK3R1/JUN/PGR/TCF7L2	1.86563049572613
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	3/104	94/9376	2.8772504091653	JUND/JUN/HSP90AB1	1.93722894222728
NA	NA	hsa04518	Integrin signaling	4/104	154/9376	2.34165834165834	PIK3R1/C3/ACTB/TNXB	1.7778918251836
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	5/104	216/9376	2.08689458689459	PIK3R1/STAT3/JUN/HSP90AB1/TNFRSF1A	1.71152071913149
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	4/104	155/9376	2.32655086848635	USP8/PBX1/ATF2/TCF7L2	1.76366600030856
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	3/104	98/9376	2.75981161695447	PIK3R1/IP6K1/INPP5B	1.85467419897766
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	4/104	156/9376	2.31163708086785	PIK3R1/STAT3/TNFRSF1A/IRF9	1.74954904279159
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	3/104	99/9376	2.73193473193473	ACTB/TPM4/SNTB1	1.83468257796978
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	4/104	158/9376	2.2823758519961	PIK3R1/TNFRSF1A/NPRL3/EIF4B	1.72163514369429
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	3/104	100/9376	2.70461538461538	IL6ST/TNFRSF1A/CXCL14	1.81493731640434
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	2/104	49/9376	3.67974882260597	JUN/ATF2	1.99175876395036
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	5/104	227/9376	1.98576753642833	PIK3R1/STAT3/TNFRSF1A/ROCK1/ATF2	1.59226820455954
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	3/104	105/9376	2.57582417582418	PIK3R1/JUN/IRF9	1.71970801106247
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	3/104	105/9376	2.57582417582418	ACTB/TPM4/SNTB1	1.71970801106247
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	5/104	232/9376	1.94297082228117	PIK3R1/ACTB/PAK2/ROCK1/DIAPH2	1.5402447423021
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	3/104	107/9376	2.52767792954709	PHKG1/CREBBP/ATF2	1.68315010504785
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	4/104	168/9376	2.14652014652015	STAT3/HSP90AB1/TNFRSF1A/IRF9	1.58806864994766
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	5/104	233/9376	1.93463189171344	ACTB/SDC3/TPM4/SNTB1/DIAPH2	1.52999423016844
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	4/104	170/9376	2.12126696832579	PIK3R1/ACTB/IGF2/TCF7L2	1.56247688121104
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	3/104	109/9376	2.48129851799577	PIK3R1/JUN/IRF9	1.64741058524845
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	3/104	109/9376	2.48129851799577	PIK3R1/STAT3/TNFRSF1A	1.64741058524845
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	3/104	110/9376	2.45874125874126	PIK3R1/STAT3/CREBBP	1.62983656789203
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	3/104	110/9376	2.45874125874126	PIK3R1/HSP90AB1/PGR	1.62983656789203
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	6/104	308/9376	1.75624375624376	TGM2/TUBB2B/CREBBP/MT-ND6/MT-ND4L/AP2A1	1.42921314170933
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	4/104	174/9376	2.07250221043325	HSP90AB1/TRAM1/SSR1/GANAB	1.51233255832919
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	3/104	116/9376	2.3315649867374	PIK3R1/ACTB/ROCK1	1.52827484424435
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	2/104	59/9376	3.05606258148631	PIK3R1/TCF7L2	1.67779881693929
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	4/104	180/9376	2.0034188034188	PIK3R1/C3/TNFRSF1A/IRF9	1.4395760169781
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	3/104	117/9376	2.31163708086785	ACTB/CHD4/EPC1	1.51195954541233
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	3/104	122/9376	2.21689785624212	PIK3R1/JUN/PAK2	1.43279774771629
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	3/104	122/9376	2.21689785624212	PIK3R1/ACTB/CREBBP	1.43279774771629
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	4/104	187/9376	1.92842451665981	JUN/HSP90AB1/IFI16/IRF9	1.35815355301751
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	2/104	63/9376	2.86202686202686	PLA2G2A/EPHX2	1.57046047824761
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	3/104	125/9376	2.16369230769231	PIK3R1/TNFRSF1A/ROCK1	1.38712125310539
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	2/104	65/9376	2.77396449704142	PBX1/ATF2	1.51991406979295
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	4/104	193/9376	1.8684734954165	PIK3R1/STAT3/CXCL14/ROCK1	1.29109597630027
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	3/104	130/9376	2.08047337278107	PIK3R1/JUN/ATF2	1.31378529497569
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	2/104	69/9376	2.61315496098105	JUN/ATF2	1.42433246344321
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	2/104	70/9376	2.57582417582418	STAT3/TNFRSF1A	1.40149273650478
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	2/104	70/9376	2.57582417582418	ACTB/SNTB1	1.40149273650478
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	3/104	133/9376	2.03354540196645	PIK3R1/STAT3/CREBBP	1.27134816215609
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	2/104	71/9376	2.53954496208017	PIK3R1/STAT3	1.37904665407709
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	3/104	134/9376	2.01836969001148	PLA2G2A/KCNMB1/ROCK1	1.25744928504907
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	5/104	275/9376	1.63916083916084	PIK3R1/TUBB2B/ATF2/MT-ND6/MT-ND4L	1.13932478289629
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	2/104	73/9376	2.46996838777661	PIK3R1/STAT3	1.3352835880726
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	2/104	75/9376	2.40410256410256	PIK3R1/REV3L	1.2929455576072
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	2/104	76/9376	2.37246963562753	ACTB/SLC26A7	1.27228282106163
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	2/104	77/9376	2.34165834165834	PIK3R1/STAT3	1.25194361707158
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	6/104	362/9376	1.49426264343391	PIK3R1/HSP90AB1/IGF2/TNXB/ATF2/EIF4B	1.01570804498098
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	4/104	214/9376	1.68511861969806	PIK3R1/JUN/TNFRSF1A/PAK2	1.07372511095911
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	2/104	78/9376	2.31163708086785	IP6K1/INPP5B	1.23191803364336
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	2/104	78/9376	2.31163708086785	PIK3R1/ACTB	1.23191803364336
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	2/104	78/9376	2.31163708086785	C3/JUN	1.23191803364336
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	3/104	144/9376	1.87820512820513	PIK3R1/STAT3/IL6ST	1.12472128295009
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	3/104	144/9376	1.87820512820513	C3/TNFRSF1A/TCF7L2	1.12472128295009
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	2/104	79/9376	2.2823758519961	STX1B/AP2A1	1.21219658980188
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	2/104	80/9376	2.25384615384615	PIK3R1/STAT3	1.19277021156856
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	2/104	83/9376	2.17238183503244	IFI16/GSDME	1.13617637565079
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	4/104	226/9376	1.59564329475834	PIK3R1/JUN/CREBBP/ROCK1	0.959943177059885
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	3/104	154/9376	1.75624375624376	JUN/ACTB/ROCK1	1.00213262223677
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	3/104	155/9376	1.74491315136476	C3/ACTB/TUBB2B	0.990371367924856
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	2/104	86/9376	2.09660107334526	KCNMB1/ATF2	1.08194611456058
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/104	26/9376	3.46745562130178	PLA2G2A	1.33427643307975
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	3/104	157/9376	1.72268495835375	PIK3R1/IGFBP3/ZFP36L1	0.967102555060638
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	3/104	157/9376	1.72268495835375	TEAD1/ACTB/TCF7L2	0.967102555060638
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	3/104	157/9376	1.72268495835375	PIK3R1/JUN/TNFRSF1A	0.967102555060638
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	2/104	88/9376	2.04895104895105	C3/SERPING1	1.04701053285035
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	3/104	160/9376	1.69038461538462	SDC3/NLGN1/LRRC4C	0.932814867950519
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	2/104	90/9376	2.0034188034188	PIK3R1/ATF2	1.01298904009329
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	4/104	235/9376	1.53453355155483	ACTB/ATF2/MT-ND6/MT-ND4L	0.878876077108508
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	2/104	91/9376	1.98140321217244	PIK3R1/JUN	0.996306155654632
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	4/104	238/9376	1.51519069166128	PIK3R1/PLA2G2A/IGF2/PAK2	0.85260231150618
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	2/104	93/9376	1.93879239040529	JUN/RBPJ	0.9635681939188
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	3/104	166/9376	1.62928637627433	KCNMB1/ROCK1/ATF2	0.866339577317417
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/104	30/9376	3.0051282051282	PLA2G2A	1.16494516017985
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	3/104	170/9376	1.59095022624434	JUN/ACTB/ROCK1	0.823484587111228
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	2/104	98/9376	1.83987441130298	PIK3R1/MARCKS	0.885147811287284
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	2/104	98/9376	1.83987441130298	PRKD3/ATF2	0.885147811287284
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/104	32/9376	2.81730769230769	TNFRSF1A	1.09056771190663
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	2/104	99/9376	1.82128982128982	PIK3R1/JUN	0.870013227866334
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	2/104	99/9376	1.82128982128982	PIK3R1/JUN	0.870013227866334
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/104	33/9376	2.73193473193473	STX1B	1.05550650327267
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	2/104	101/9376	1.78522467631379	CREBBP/TCF7L2	0.840259174953346
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	2/104	103/9376	1.75056011949216	RNMT/SRRM1	0.81116567248003
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	2/104	105/9376	1.71721611721612	JUN/USP8	0.78270299527204
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	3/104	181/9376	1.49426264343391	C3/TNFRSF1A/CREBBP	0.711110030476053
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	2/104	108/9376	1.66951566951567	KPNB1/SRRM1	0.741131389191366
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	1/104	37/9376	2.43659043659044	TCF7L2	0.927255123554242
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	2/104	110/9376	1.63916083916084	CREBBP/ROCK1	0.714127815461799
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/104	38/9376	2.37246963562753	PIK3R1	0.897807449943643
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/104	39/9376	2.31163708086785	CHDH	0.869276434695947
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	2/104	112/9376	1.60989010989011	STAT3/TNFRSF1A	0.687665007353683
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	2/104	115/9376	1.56789297658863	JUND/ATF2	0.648936305619764
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/104	41/9376	2.19887429643527	CHDH	0.814749331351731
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	3/104	195/9376	1.38698224852071	PIK3R1/C3/ACTB	0.578334302331407
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/104	43/9376	2.09660107334526	PLA2G2A	0.763286986229827
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	2/104	120/9376	1.5025641025641	PIK3R1/JUN	0.586794467825078
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	5/104	368/9376	1.22491638795987	ACTB/TNFRSF1A/TUBB2B/MT-ND6/MT-ND4L	0.466172249733259
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	3/104	205/9376	1.31932457786116	PIK3R1/MT-ND6/MT-ND4L	0.489571949919356
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/104	47/9376	1.91816693944354	PIK3R1	0.668295643146605
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/104	48/9376	1.87820512820513	PIK3R1	0.646008028161351
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	3/104	212/9376	1.27576197387518	PIK3R1/ACTB/PRKD3	0.430105865902415
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	1/104	49/9376	1.83987441130298	GXYLT2	0.624247767260365
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	5/104	388/9376	1.16177636796193	PIK3R1/TNFRSF1A/TUBB2B/MT-ND6/MT-ND4L	0.344679145928514
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	1/104	51/9376	1.76772247360483	PLA2G2A	0.582211149598672
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	1/104	51/9376	1.76772247360483	ACTB	0.582211149598672
NA	NA	hsa04081	Hormone signaling	3/104	219/9376	1.2349841938883	PIK3R1/STAT3/IGF2	0.372648774482571
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	1/104	53/9376	1.70101596516691	AP2A1	0.542005380617517
Genetic Information Processing	Translation	hsa03010	Ribosome	3/104	222/9376	1.21829521829522	RPL35/RPLP0/RPL36A	0.348602784891996
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/104	54/9376	1.66951566951567	REV3L	0.522538955455978
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	2/104	138/9376	1.30657748049052	MT-ND6/MT-ND4L	0.384243395465831
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	2/104	138/9376	1.30657748049052	PGR/AR	0.384243395465831
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	2/104	138/9376	1.30657748049052	PIK3R1/PHKG1	0.384243395465831
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	1/104	56/9376	1.60989010989011	GANAB	0.484789544174464
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	1/104	56/9376	1.60989010989011	CSNK1G3	0.484789544174464
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	1/104	56/9376	1.60989010989011	C3	0.484789544174464
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1/104	59/9376	1.52803129074316	PIK3R1	0.430886823627403
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	1/104	60/9376	1.5025641025641	PIK3R1	0.41358801569336
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	2/104	149/9376	1.21011874032008	MT-ND6/MT-ND4L	0.273806187902565
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	2/104	150/9376	1.20205128205128	PIK3R1/TCF7L2	0.264189839619119
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	1/104	62/9376	1.45409429280397	PIK3R1	0.379917560491208
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	1/104	63/9376	1.43101343101343	TCF7L2	0.363522982833709
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	2/104	154/9376	1.17082917082917	TPM4/ATF2	0.226373419289944
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	1/104	65/9376	1.38698224852071	PIK3R1	0.331562308754031
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/104	66/9376	1.36596736596737	RDH5	0.315976718032501
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	2/104	158/9376	1.14118792599805	TFDP2/CREBBP	0.189549807012659
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	3/104	250/9376	1.08184615384615	OSBP/LAMP5/AP2A1	0.138913241044034
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	3/104	250/9376	1.08184615384615	PSD3/USP8/AP2A1	0.138913241044034
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	1/104	67/9376	1.34557979334099	CREBBP	0.300642118566674
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/104	68/9376	1.32579185520362	RDH5	0.285549949807947
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	1/104	69/9376	1.30657748049052	PIK3R1	0.27069207149059
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	1/104	71/9376	1.26977248104009	JUN	0.241648569222516
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	1/104	71/9376	1.26977248104009	PIK3R1	0.241648569222516
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	1/104	73/9376	1.2349841938883	CREBBP	0.213453935584365
Human Diseases	Cancer: specific types	hsa05218	Melanoma	1/104	73/9376	1.2349841938883	PIK3R1	0.213453935584365
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	1/104	75/9376	1.20205128205128	IGFBP3	0.186055715740408
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	1/104	75/9376	1.20205128205128	ATF2	0.186055715740408
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	1/104	76/9376	1.18623481781377	FABP5	0.172640146810722
Human Diseases	Cancer: specific types	hsa05214	Glioma	1/104	76/9376	1.18623481781377	PIK3R1	0.172640146810722
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	3/104	268/9376	1.00918484500574	TUBB2B/MT-ND6/MT-ND4L	0.016156352289494
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	1/104	77/9376	1.17082917082917	PIK3R1	0.159406074846791
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	1/104	82/9376	1.09943714821764	HSP90AB1	0.0957789009062687
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	1/104	83/9376	1.08619091751622	CREBBP	0.0835291722810465
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	1/104	83/9376	1.08619091751622	EPHX2	0.0835291722810465
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	5/104	480/9376	0.939102564102564	TNFRSF1A/TUBB2B/MT-ND6/MT-ND4L/ATXN1	-0.145056713933539
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	1/104	87/9376	1.03625110521662	TPM4	0.0359759269765523
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	1/104	89/9376	1.01296456352636	TNXB	0.0130145985702607
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	1/104	89/9376	1.01296456352636	TUBB2B	0.0130145985702607
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	3/104	298/9376	0.907589055240062	IL6ST/TNFRSF1A/CXCL14	-0.171692786645996
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	1/104	93/9376	0.969396195202647	JUN	-0.0314114741629918
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	1/104	93/9376	0.969396195202647	PIK3R1	-0.0314114741629918
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	1/104	95/9376	0.948987854251012	JUN	-0.052924115010021
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	1/104	99/9376	0.910644910644911	PIK3R1	-0.0946561222371131
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	1/104	99/9376	0.910644910644911	C3	-0.0946561222371131
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	1/104	102/9376	0.883861236802413	PLA2G2A	-0.124899106988808
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	1/104	103/9376	0.875280059746079	PIK3R1	-0.134790713735488
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	1/104	104/9376	0.866863905325444	PLA2G2A	-0.144591035524104
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	1/104	105/9376	0.858608058608059	TNFRSF1A	-0.15430202051839
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	1/104	115/9376	0.783946488294314	PIK3R1	-0.24688625054792
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	1/104	122/9376	0.738965952080706	PIK3R1	-0.307346252618935
Genetic Information Processing	Transcription	hsa03040	Spliceosome	2/104	243/9376	0.742006964229187	SF1/U2SURP	-0.431538936736079
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	1/104	133/9376	0.677848467322152	PIK3R1	-0.39627360174647
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	1/104	133/9376	0.677848467322152	ATF2	-0.39627360174647
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	2/104	254/9376	0.709872804360993	PHKG1/STIM1	-0.496450395346608
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	1/104	142/9376	0.634886240520043	UBR5	-0.464293959288816
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	1/104	143/9376	0.630446476600323	C3	-0.471617101254049
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	1/104	149/9376	0.605059370160041	PIK3R1	-0.514647994460596
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	1/104	157/9376	0.574228319451249	PBX1	-0.569770929049284
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	1/104	169/9376	0.533454710969504	PIK3R1	-0.648177103232299
Human Diseases	Substance dependence	hsa05034	Alcoholism	1/104	191/9376	0.472009665726943	ATF2	-0.78076200705403
NA	NA	hsa04382	Cornified envelope formation	1/104	217/9376	0.415455512229706	EPHX2	-0.922654285503475
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1/104	370/9376	0.243659043659044	C3	-1.57205633652165