category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	8/90	109/9376	7.6460754332314	FOS/HLA-DQA2/HLA-DQB1/JUN/MAPK10/HSP90AA1/GATA3/STAT3	6.87070792415511
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	7/90	94/9376	7.75791962174941	FOS/JUND/FOSB/IL17RB/JUN/MAPK10/HSP90AA1	6.48259246397321
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	7/90	112/9376	6.51111111111111	HLA-DQA2/HSPA1A/LAMA3/HLA-DQB1/LAMB1/MAPK10/STAT3	5.77618984198643
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	6/90	93/9376	6.72114695340502	FOS/HLA-DQA2/HLA-DQB1/JUN/MAPK10/GATA3	5.45849548611452
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	5/90	66/9376	7.89225589225589	HLA-DQA2/HLA-DQB1/JUN/GATA3/STAT3	5.53160389658424
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	7/90	142/9376	5.13552425665102	FOS/JUNB/JUND/SOCS3/FOSB/JUN/MAPK10	4.88846334225688
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	10/90	300/9376	3.47259259259259	FOS/JUND/RPS6KA2/DUSP1/HSPA1A/HGF/NTF3/JUN/NR4A1/MAPK10	4.28507572267077
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	8/90	205/9376	4.06547425474255	HLA-DQA2/VIM/CD44/HLA-DQB1/JUN/HLA-B/MAPK10/STAT3	4.36876626655499
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	5/90	82/9376	6.35230352303523	HLA-DQA2/HSPA1A/HLA-DQB1/HLA-B/HSP90AA1	4.79224352405835
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	8/90	224/9376	3.72063492063492	FOS/ZFP36/HLA-DQA2/EGR1/HLA-DQB1/JUN/HLA-B/MAPK10	4.0572224958759
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	8/90	233/9376	3.57691940867907	COL6A1/VIM/SGCE/SUN1/ANK2/COL3A1/FBN1/TPM4	3.92127219960481
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	5/90	95/9376	5.48304093567251	FOS/HLA-DQA2/CXCL12/HLA-DQB1/JUN	4.32344236736182
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	6/90	142/9376	4.4018779342723	FOS/DUSP1/JUN/MAPK10/HSP90AA1/GSTA1	4.02124483970256
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	5/90	101/9376	5.15731573157316	EGR1/COL3A1/JUN/MAPK10/STAT3	4.13532159837609
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	5/90	109/9376	4.77879714576962	SLC27A6/RPS6KA2/SOCS3/MAPK10/STAT3	3.90651772674668
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	4/90	69/9376	6.03929146537842	FOS/SLC18A2/FOSB/JUN	4.13601132946513
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	6/90	160/9376	3.90666666666667	HLA-DQA2/CDH4/HLA-DQB1/HLA-B/ALCAM/NRCAM	3.65070332822655
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	4/90	70/9376	5.95301587301587	HLA-DQA2/SGCE/HLA-DQB1/HLA-B	4.09477241498948
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	4/90	71/9376	5.86917057902973	FOS/SOCS3/MAPK10/STAT3	4.05432470809006
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	5/90	119/9376	4.37721755368814	FOS/JUNB/SOCS3/JUN/MAPK10	3.64997542180989
Human Diseases	Immune disease	hsa05330	Allograft rejection	3/90	39/9376	8.01367521367521	HLA-DQA2/HLA-DQB1/HLA-B	4.32082650400308
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	5/90	122/9376	4.2695810564663	FOS/JUNB/SOCS3/MAPK10/STAT3	3.57849017754626
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	4/90	78/9376	5.34245014245014	FOS/HLA-DQA2/HLA-DQB1/JUN	3.79122818619421
NA	NA	hsa04517	IgSF CAM signaling	8/90	299/9376	2.78736529171312	APP/ANK2/SLIT3/ACTR3B/MAPK10/ROBO3/EPB41L2/NRCAM	3.09221939590705
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	3/90	44/9376	7.1030303030303	HLA-DQA2/HLA-DQB1/HLA-B	3.99463453926657
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	3/90	45/9376	6.94518518518518	HLA-DQA2/HLA-DQB1/HLA-B	3.93550168186255
Human Diseases	Infectious disease: viral	hsa05162	Measles	5/90	136/9376	3.83006535947712	FOS/HSPA1A/JUN/MAPK10/STAT3	3.27282276509233
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	5/90	138/9376	3.77455716586151	FOS/RPS6KA2/ACTR3B/JUN/MAPK10	3.23248705809283
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	4/90	89/9376	4.68214731585518	COL6A1/LAMA3/CD44/LAMB1	3.43598289872367
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	6/90	196/9376	3.1891156462585	FOS/ZFP36/JUN/HLA-B/MAPK10/STAT3	3.04907392047375
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	3/90	49/9376	6.37823129251701	SLC18A2/FOSB/JUN	3.7158577509676
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	3/90	50/9376	6.25066666666667	HLA-DQA2/CXCL12/HLA-DQB1	3.66474953386273
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	6/90	203/9376	3.07914614121511	COL6A1/HGF/LAMA3/LAMB1/JUN/MAPK10	2.94828791318433
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	3/90	54/9376	5.78765432098765	HLA-DQA2/HLA-DQB1/HLA-B	3.47342295200965
NA	NA	hsa04518	Integrin signaling	5/90	154/9376	3.38239538239538	COL6A1/HGF/LAMA3/LAMB1/FBN1	2.93463567925094
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/90	21/9376	9.92169312169312	CHST7/CSGALNACT1	4.02928127439578
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	6/90	216/9376	2.89382716049383	FOS/HSPA1A/JUN/MAPK10/HSP90AA1/STAT3	2.77212004194011
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	6/90	217/9376	2.88049155145929	FOS/RPS6KA2/JUN/HSP90AA1/STAT3/GSTA1	2.7591148411754
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	8/90	362/9376	2.30227133210559	COL6A1/HGF/LAMA3/NTF3/LAMB1/NR4A1/HSP90AA1/OSMR	2.4876515157538
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	4/90	115/9376	3.62357487922705	FOS/EGR1/JUND/GATA3	2.78680124063871
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	5/90	174/9376	2.99361430395913	PPP1R15A/HSPA1A/DNAJB1/MAPK10/HSP90AA1	2.61316723351075
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	4/90	120/9376	3.47259259259259	RPS6KA2/NTF3/JUN/MAPK10	2.68363883017888
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	5/90	180/9376	2.89382716049383	HLA-DQA2/SOCS3/HLA-DQB1/HLA-B/PILRA	2.52562963757757
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	3/90	70/9376	4.4647619047619	SOCS3/MAPK10/STAT3	2.86439854744233
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	6/90	248/9376	2.52043010752688	FOS/RHOB/ACTR3B/JUN/MAPK10/HSP90AA1	2.3888948757335
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	5/90	184/9376	2.83091787439613	EPHA7/EPHA5/CXCL12/SLIT3/ROBO3	2.46925147252696
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	4/90	130/9376	3.20547008547009	FOS/COL3A1/JUN/MAPK10	2.49280585664156
Human Diseases	Immune disease	hsa05310	Asthma	2/90	32/9376	6.51111111111111	HLA-DQA2/HLA-DQB1	3.0742578777284
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	3/90	78/9376	4.00683760683761	FOS/JUN/MAPK10	2.62515564080132
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	4/90	139/9376	2.99792166266986	FOS/HSPA1A/JUN/HSP90AA1	2.3362156955995
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	5/90	204/9376	2.55337690631808	HGF/CD44/ANK2/DDX5/STAT3	2.20827145311685
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	3/90	87/9376	3.59233716475096	FOS/JUN/MAPK10	2.39143832117344
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/90	38/9376	5.48304093567251	NNMT/NT5E	2.72602680096897
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	3/90	90/9376	3.47259259259259	FOS/JUN/STAT3	2.32034216556112
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	3/90	91/9376	3.43443223443223	FOS/IFITM1/JUN	2.29731202198401
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	3/90	93/9376	3.36057347670251	EGR1/JUN/MAPK10	2.25220218466046
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	4/90	157/9376	2.65421089879689	FOS/SOCS3/JUN/MAPK10	2.05774402741661
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	5/90	227/9376	2.29466470876162	FOS/HGF/JUN/MAPK10/GSTA1	1.9439092117446
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	3/90	99/9376	3.15690235690236	FOS/JUN/MAPK10	2.12391365590417
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	3/90	99/9376	3.15690235690236	FOS/JUN/MAPK10	2.12391365590417
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	3/90	100/9376	3.12533333333333	HLA-DQA2/CD44/HLA-DQB1	2.10348411626265
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	4/90	163/9376	2.55650988411725	FOS/JUN/MAPK10/STAT3	1.97350259934178
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	2/90	47/9376	4.43309692671395	SOCS3/MAPK10	2.32279028387141
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	3/90	103/9376	3.03430420711974	FOS/JUN/MAPK10	2.04369900255729
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	3/90	103/9376	3.03430420711974	LAMA3/COL3A1/LAMB1	2.04369900255729
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	2/90	49/9376	4.25215419501134	ST6GAL2/GALNT3	2.24693616090637
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	4/90	170/9376	2.45124183006536	NEDD4L/ACTR3B/JUN/MAPK10	1.87984186146256
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	4/90	173/9376	2.408734746307	HLA-DQA2/SOCS3/HLA-DQB1/DNAJB1	1.84111162572719
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	3/90	109/9376	2.86727828746177	FOS/JUN/MAPK10	1.93039092847439
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	3/90	110/9376	2.84121212121212	RPS6KA2/MAPK10/HSP90AA1	1.91225838187608
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	5/90	250/9376	2.08355555555556	HSPA1A/NEDD4L/ACTR3B/RAB11FIP1/HLA-B	1.70951733309726
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	3/90	115/9376	2.71768115942029	SLC18A2/DUSP1/APP	1.82454711851201
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	2/90	56/9376	3.72063492063492	HSPA1A/CLK1	2.01024448216942
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	3/90	122/9376	2.56174863387978	FOS/JUN/MAPK10	1.7093022162831
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	2/90	62/9376	3.36057347670251	HEY2/DTX4	1.8358525805689
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	4/90	200/9376	2.08355555555556	FOS/ACTR3B/JUN/MAPK10	1.52486723157446
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/90	14/9376	7.44126984126984	B3GNT2	2.37434457545836
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	2/90	65/9376	3.20547008547009	PDE8B/NR4A1	1.75651652424714
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	4/90	205/9376	2.03273712737127	JUN/HLA-B/GSN/STAT3	1.47180721459278
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	3/90	133/9376	2.34987468671679	FOS/SLC18A2/MAPK10	1.54349543942814
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/90	68/9376	3.0640522875817	ALDH1A1/ALDH1A3	1.68166512283534
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	2/90	68/9376	3.0640522875817	ZBTB16/STAT3	1.68166512283534
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	3/90	137/9376	2.28126520681265	FOS/JUN/MAPK10	1.48723427665792
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	2/90	70/9376	2.97650793650794	HGF/JUN	1.63402467989517
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	2/90	71/9376	2.93458528951487	JUN/MAPK10	1.61083634509897
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	4/90	214/9376	1.9472481827622	FOS/JUN/HLA-B/MAPK10	1.37996501729499
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	2/90	73/9376	2.85418569254186	HGF/STAT3	1.56565366311601
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	2/90	75/9376	2.77807407407407	REV3L/GSTA1	1.52197743071063
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	2/90	77/9376	2.70591630591631	MAPK10/STAT3	1.47971307861747
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	3/90	148/9376	2.11171171171171	FOS/HEY2/JUN	1.34202868574339
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	2/90	80/9376	2.60444444444444	HGF/STAT3	1.41877710968645
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	3/90	155/9376	2.01634408602151	HLA-DQA2/HLA-DQB1/HLA-B	1.25605933560014
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	4/90	238/9376	1.75088702147526	PLA2G2A/HGF/NTF3/MAPK10	1.15512784491234
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	4/90	238/9376	1.75088702147526	FOS/JUN/MAPK10/STAT3	1.15512784491234
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	2/90	86/9376	2.42273901808786	JUN/MAPK10	1.30484571560581
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	2/90	88/9376	2.36767676767677	A2M/TFPI	1.26898431964264
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	5/90	333/9376	1.56423089756423	COL6A1/LAMA3/LAMB1/HEY2/HLA-B	1.03208453193687
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	3/90	168/9376	1.86031746031746	MAPK10/HSP90AA1/STAT3	1.10770285710381
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	3/90	168/9376	1.86031746031746	SOCS3/OSMR/STAT3	1.10770285710381
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/90	26/9376	4.00683760683761	PLA2G2A	1.51141384156297
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	2/90	93/9376	2.24038231780167	LAMA3/LAMB1	1.18343775084244
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	4/90	253/9376	1.64707949055775	CD44/ACTR3B/JUN/MAPK10	1.02716830799655
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/90	28/9376	3.72063492063492	B3GNT2	1.41932706773096
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	2/90	98/9376	2.12607709750567	ACTR3B/GSN	1.10318038870288
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	3/90	178/9376	1.75580524344569	WIF1/JUN/MAPK10	1.00222620122428
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	2/90	99/9376	2.10460157126824	HLA-DQA2/HLA-DQB1	1.08770726409662
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	2/90	99/9376	2.10460157126824	SGCE/TPM4	1.08770726409662
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/90	30/9376	3.47259259259259	PLA2G2A	1.33534306756048
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	3/90	181/9376	1.72670349907919	HLA-DQA2/HLA-DQB1/MAPK10	0.971881298428684
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	2/90	102/9376	2.04270152505447	PLA2G2A/CLCA1	1.04236327590064
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	2/90	103/9376	2.02286947141316	COL6A1/COL3A1	1.02759327300075
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/90	32/9376	3.25555555555556	MAPK10	1.25821441366707
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	2/90	105/9376	1.98433862433862	JUN/MAPK10	0.99854683373612
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	2/90	105/9376	1.98433862433862	JUN/MAPK10	0.99854683373612
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	2/90	105/9376	1.98433862433862	SGCE/TPM4	0.99854683373612
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	3/90	187/9376	1.67130124777184	JUN/MAPK10/HSP90AA1	0.912844251887756
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/90	36/9376	2.89382716049383	GALNT3	1.12075505472662
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	3/90	201/9376	1.55489220563847	DDX5/PROM1/ZBTB16	0.782881751405917
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/90	38/9376	2.74152046783626	NEDD4L	1.05897571266444
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	4/90	298/9376	1.39835943325876	CXCL12/IL32/IL17RB/OSMR	0.687987744408758
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/90	43/9376	2.42273901808786	PLA2G2A	0.920537298813781
NA	NA	hsa04519	Cadherin signaling	5/90	404/9376	1.28932893289329	CDH4/VIM/ACTR3B/MAPK10/PCDH15	0.585235239049531
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	2/90	128/9376	1.62777777777778	PDE8B/NT5E	0.704011196113927
NA	NA	hsa04081	Hormone signaling	3/90	219/9376	1.42709284627093	DIO2/TRH/STAT3	0.629593594300599
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	1/90	46/9376	2.26473429951691	PSME4	0.846505811443691
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	2/90	133/9376	1.56658312447786	MAPK10/STAT3	0.647851594888082
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	3/90	226/9376	1.38289085545723	FOS/JUN/MAPK10	0.573602743754552
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	3/90	227/9376	1.37679882525698	CXCL12/HLA-B/STAT3	0.565754749036292
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	2/90	138/9376	1.50982286634461	SOCS3/MAPK10	0.593967151823675
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	1/90	50/9376	2.08355555555556	HGF	0.756277244248969
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	3/90	232/9376	1.34712643678161	CXCL12/ACTR3B/GSN	0.527055230152611
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	1/90	51/9376	2.04270152505447	PLA2G2A	0.735043818760138
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	2/90	142/9376	1.46729264475743	SOCS3/NEDD4L	0.552370829485319
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	2/90	143/9376	1.45703185703186	HLA-DQA2/HLA-DQB1	0.54217018035111
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	2/90	144/9376	1.44691358024691	TBX3/STAT3	0.532046331507811
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/90	54/9376	1.92921810699588	REV3L	0.674143804851108
Genetic Information Processing	Transcription	hsa03040	Spliceosome	3/90	243/9376	1.28614540466392	HSPA1A/DDX5/HNRNPU	0.444913657014431
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	1/90	56/9376	1.86031746031746	ST6GAL2	0.635678243486478
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/90	59/9376	1.76572504708098	NT5E	0.580835784158962
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	1/90	59/9376	1.76572504708098	GSTA1	0.580835784158962
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	2/90	154/9376	1.35295815295815	FOS/JUN	0.434774007961707
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	2/90	155/9376	1.344229390681	PDE8B/NR4A1	0.425419447704322
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	2/90	156/9376	1.33561253561254	SOCS3/STAT3	0.416128600529866
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	1/90	62/9376	1.68028673835125	HSPA1A	0.529068964154231
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	1/90	63/9376	1.65361552028219	PLA2G2A	0.512436885064449
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	1/90	67/9376	1.55489220563847	RPS6KA2	0.448732023631137
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	3/90	268/9376	1.16616915422886	SLC18A2/DUSP1/MAPK10	0.271705762120247
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	1/90	69/9376	1.50982286634461	MAPK10	0.418438418517498
Organismal Systems	Endocrine system	hsa04924	Renin secretion	1/90	69/9376	1.50982286634461	CLCA1	0.418438418517498
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	2/90	170/9376	1.22562091503268	HGF/GSTA1	0.292254283271876
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	1/90	70/9376	1.48825396825397	GSTA1	0.403650812348021
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	3/90	275/9376	1.13648484848485	EGR1/HSPA1A/MAPK10	0.22615114189491
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	1/90	72/9376	1.44691358024691	MAPK10	0.374755057233657
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/90	73/9376	1.42709284627093	GSTA1	0.360632423140988
Human Diseases	Cancer: specific types	hsa05218	Melanoma	1/90	73/9376	1.42709284627093	HGF	0.360632423140988
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	1/90	75/9376	1.38903703703704	RPRM	0.333003893771547
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	1/90	76/9376	1.37076023391813	SLC27A6	0.319485404605958
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	1/90	78/9376	1.33561253561254	INPP4B	0.293010550015535
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	1/90	78/9376	1.33561253561254	ACTR3B	0.293010550015535
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/90	79/9376	1.31870604781997	GSTA1	0.280043172020933
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	1/90	79/9376	1.31870604781997	SLC18A2	0.280043172020933
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1/90	82/9376	1.27046070460705	GSTA1	0.242159951241025
Human Diseases	Substance dependence	hsa05034	Alcoholism	2/90	191/9376	1.09086678301338	SLC18A2/FOSB	0.124903557872955
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	2/90	193/9376	1.07956246401842	CXCL12/STAT3	0.109947950992434
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	1/90	85/9376	1.22562091503268	NT5E	0.205707507644989
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	1/90	86/9376	1.21136950904393	PCLO	0.193854666793598
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	1/90	86/9376	1.21136950904393	SGCE	0.193854666793598
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	1/90	87/9376	1.19744572158365	TPM4	0.182144233152731
Human Diseases	Substance dependence	hsa05032	Morphine addiction	1/90	91/9376	1.14481074481074	PDE8B	0.136654231019813
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	2/90	205/9376	1.01636856368564	COL3A1/MAPK10	0.0233276886116837
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	3/90	323/9376	0.967595459236326	VIM/CD44/STAT3	-0.0583449705892044
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	2/90	212/9376	0.982809224318658	HGF/DOCK4	-0.0249237517463786
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	1/90	97/9376	1.07399770904926	FOS	0.0721184040356367
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	1/90	98/9376	1.06303854875283	INPP4B	0.0617567756865487
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	1/90	98/9376	1.06303854875283	NR4A1	0.0617567756865487
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	1/90	99/9376	1.05230078563412	MAPK10	0.0515008722890698
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	1/90	100/9376	1.04177777777778	CXCL12	0.0413482866852132
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	1/90	104/9376	1.0017094017094	PLA2G2A	0.00172570534939234
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	1/90	105/9376	0.992169312169312	CXCL12	-0.00794371809250415
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	1/90	106/9376	0.982809224318658	HSP90AA1	-0.0175227026846701
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	1/90	110/9376	0.947070707070707	STAT3	-0.0549716585529441
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	1/90	110/9376	0.947070707070707	FBN1	-0.0549716585529441
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	1/90	115/9376	0.905893719806763	FOS	-0.0999611257414048
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	1/90	116/9376	0.898084291187739	CXCL12	-0.108731951771578
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	1/90	122/9376	0.853916211293261	DIO2	-0.159885744980061
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	1/90	125/9376	0.833422222222222	MAPK10	-0.184573897677593
Organismal Systems	Immune system	hsa04611	Platelet activation	1/90	126/9376	0.826807760141093	COL3A1	-0.192679445731689
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	1/90	133/9376	0.783291562238931	HLA-B	-0.247792249651974
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	1/90	134/9376	0.777446102819237	PLA2G2A	-0.25544486335335
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	1/90	138/9376	0.754911433172303	RPS6KA2	-0.285539483599379
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	1/90	140/9376	0.744126984126984	EGR1	-0.300288774107472
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	1/90	144/9376	0.723456790123457	MAPK10	-0.329222039386049
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	1/90	144/9376	0.723456790123457	MAPK10	-0.329222039386049
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	1/90	149/9376	0.699179716629381	MAPK10	-0.364386721984275
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	1/90	150/9376	0.694518518518519	HGF	-0.371292644543065
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	1/90	154/9376	0.676479076479076	TPM4	-0.398513215801369
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	1/90	157/9376	0.663552724699222	HLA-B	-0.418521224708589
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	1/90	158/9376	0.659353023909986	RPS6KA2	-0.425115835737942
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	1/90	169/9376	0.616436554898093	MAPK10	-0.49535214132815
Cellular Processes	Cell motility	hsa04814	Motor proteins	1/90	194/9376	0.536998854524628	TPM4	-0.641515035318299
NA	NA	hsa04082	Neuroactive ligand signaling	1/90	199/9376	0.523506420993858	SLC18A2	-0.668845451956507
NA	NA	hsa04382	Cornified envelope formation	1/90	217/9376	0.480081925243216	LAMA3	-0.762839734719137
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	2/90	388/9376	0.536998854524628	APP/MAPK10	-0.916978070490685
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	1/90	235/9376	0.443309692671395	RPS6KA2	-0.850830969946988
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	1/90	250/9376	0.416711111111111	LAMP5	-0.92025042984284
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	1/90	254/9376	0.410148731408574	HGF	-0.938224771866385
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	2/90	480/9376	0.434074074074074	APP/MAPK10	-1.25307012212303
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	1/90	308/9376	0.338239538239538	MAPK10	-1.16255356309839
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1/90	370/9376	0.281561561561562	TRH	-1.38808801419673