category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	92/1181	222/9376	3.29005042298861	RPS7/RPL29/RPS3A/RPL35/RPS24/RPL13/RPS15/RPS19/RPS6/RPL8/RPL36A/RPL22L1/RPS3/RPS18/RPL18A/RPL39/RPS12/RPL26/RPS5/RPS15A/RPS10/RPS27A/RPS26/RPS9/RPL32/RPSA/RPL36/RPL7/RPLP0/RPL17/RPLP2/RPS8/RPL4/RPL9/RPL12/RPL11/RPL34/RPS25/RPLP1/MRPS24/RPS13/MRPL12/RPL19/RPS21/RPL6/RPL7A/MRPL14/RPL14/MRPL18/MRPL24/RPS16/RPS2/RPL41/RPS17/FAU/MRPL37/MRPL4/MRPL52/UBA52/MRPL13/MRPL47/MRPS12/MRPS17/MRPL33/MRPL41/MRPS27/MRPS6/MRPL15/MRPL50/MRPL38/MRPL16/MRPL53/MRPL42/MRPL54/DAP3/MRPS2/MRPL3/MRPS15/RPL26L1/RPS27L/MRPL11/MRPS33/MRPL46/MRPL17/MRPL22/MRPL28/MRPS34/RSL24D1/MRPS25/MRPS35/MRPL45/MRPL21	13.1084754818957
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	84/1181	238/9376	2.80201225282662	C3/C1R/RPS7/RPL29/RPS3A/RPL35/RPS24/RPL13/RPS15/RPS19/RPS6/RPL8/CFD/RPL36A/RPL22L1/RPS3/RPS18/RPL18A/RPL39/RPS12/RPL26/FOS/RPS5/RPS15A/RPS10/RPS27A/RPS26/RPS9/C1S/RPL32/JUN/RPSA/RPL36/RPL7/RPLP0/RPL17/RPLP2/C2/RPS8/RPL4/RPL9/RPL12/RPL11/RPL34/RPS25/RPLP1/NFKBIA/RPS13/RPL19/RPS21/TNFRSF1A/RPL6/RPL7A/MYD88/ISG15/NFKBIB/RPL14/RPS16/MAPK3/RPS2/RPL41/RPS17/FAU/IL1B/UBA52/CASP1/CXCL8/IRAK1/MASP1/PIK3R2/IFNAR2/NRP1/CCL2/TLR4/RPL26L1/RPS27L/MAPK12/ACE/OAS2/RSL24D1/MX2/STAT2/TLR3/CFB	10.6894841921511
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	80/1181	268/9376	2.36986110935585	MT-ND4/MT-CO2/RPS27A/NDUFS5/TUBB/DUSP1/UBE2L6/MAOB/MT-ATP6/TUBA1B/PSMB3/NDUFA13/MAP3K5/TXN/TUBB4B/NDUFA11/TUBA1C/SLC39A14/TUBB6/UQCR11/PSMA2/CYCS/PSMA4/NDUFV1/UQCRQ/COX7B/PSMA3/HSPA5/COX6A1/NDUFS8/NDUFA7/UBB/TUBB3/NDUFA4/PPIF/TUBA1A/PSMB6/XBP1/VDAC1/SDHB/SLC39A6/NDUFB8/UBC/UBA52/NDUFB9/TP53/COX5B/COX6C/NFE2L2/PARK7/CALM2/TUBB2A/CYC1/NDUFV2/NDUFS7/PSMD14/TRAP1/COX7A2/NDUFA9/NDUFS6/PSMA1/PSMB7/NDUFB3/PSMD9/SDHC/NDUFAB1/PSMC3/EIF2S1/PSMB2/SLC39A8/CALM3/UBE2G2/PSMA5/UQCR10/UQCRC1/KIF5A/COX5A/SLC25A5/NDUFB6/SLC39A1	8.63711158180408
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	74/1181	275/9376	2.13632206912478	MT-ND4/MT-CO2/HSPA1B/HSPA1A/EGR1/NDUFS5/TUBB/MT-ATP6/TUBA1B/PSMB3/NDUFA13/TUBB4B/NDUFA11/TUBA1C/TUBB6/CACNA1C/HSPA8/UQCR11/CAV1/PSMA2/CYCS/PSMA4/NDUFV1/UQCRQ/COX7B/LAMC1/NCAM2/PSMA3/MAPK3/HSPA5/COX6A1/NDUFS8/PRNP/NDUFA7/TUBB3/NDUFA4/PPIF/TUBA1A/PSMB6/IL1B/VDAC1/SDHB/NDUFB8/NDUFB9/COX5B/COX6C/CAV2/TUBB2A/CYC1/NDUFV2/NDUFS7/PSMD14/COX7A2/NDUFA9/NDUFS6/PSMA1/PSMB7/NDUFB3/PSMD9/PIK3R2/SDHC/NDUFAB1/PSMC3/EIF2S1/PSMB2/MAPK12/PSMA5/UQCR10/UQCRC1/KIF5A/COX5A/SLC25A5/NDUFB6/PPP3CA	7.26037979002661
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	90/1181	368/9376	1.94161175127931	ACTB/MT-ND4/MT-CO2/PFN1/GPX1/NDUFS5/TUBB/MT-ATP6/TUBA1B/PSMB3/NDUFA13/MAP3K5/ACTG1/TUBB4B/NDUFA11/TUBA1C/TUBB6/TNFRSF1A/UQCR11/PSMA2/CYCS/PSMA4/NDUFV1/UQCRQ/COX7B/PSMA3/HSPA5/COX6A1/NDUFS8/NDUFA7/TUBB3/NDUFA4/SRSF3/SIGMAR1/TUBA1A/PSMB6/XBP1/VDAC1/SDHB/NDUFB8/NDUFB9/TP53/COX5B/COX6C/CASP1/CHCHD10/TUBB2A/ALYREF/GPX3/CYC1/NUP35/NDUFV2/NDUFS7/OPTN/PSMD14/NXT1/DERL1/TOMM40/COX7A2/NDUFA9/NDUFS6/PSMA1/PSMB7/NDUFB3/PSMD9/ANG/DCTN6/SDHC/NDUFAB1/MAP2K3/PSMC3/NEFH/NUP93/EIF2S1/PSMB2/NDC1/MAPK12/TANK/GLE1/PSMA5/UBQLN4/UQCR10/UQCRC1/SEH1L/KIF5A/COX5A/BID/C9orf72/NDUFB6/PPP3CA	6.9954828864873
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	47/1181	157/9376	2.37665370489222	MT-CO2/INSR/FOS/NDUFS5/JUN/NDUFA13/MAP3K5/IRS2/NDUFA11/TNFRSF1A/UQCR11/CYCS/NDUFV1/UQCRQ/COX7B/COX6A1/NDUFS8/NDUFA7/NDUFA4/IL1B/XBP1/SDHB/NDUFB8/NDUFB9/COX5B/COX6C/CXCL8/CDC42/CYC1/NDUFV2/NDUFS7/FAS/ADIPOR1/COX7A2/NDUFA9/NDUFS6/NDUFB3/PIK3R2/SDHC/NDUFAB1/EIF2S1/MAPK12/UQCR10/UQCRC1/COX5A/BID/NDUFB6	6.60341717037657
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	88/1181	388/9376	1.80060581195387	MT-ND4/MT-CO2/INSR/NDUFS5/TUBB/MT-ATP6/TUBA1B/PSMB3/NDUFA13/MAP3K5/IRS2/GAPDH/DKK1/TUBB4B/NDUFA11/TUBA1C/SLC39A14/TUBB6/CACNA1C/TNFRSF1A/UQCR11/WNT5B/PSMA2/CYCS/PSMA4/NDUFV1/WNT4/UQCRQ/COX7B/HSD17B10/PSMA3/MAPK3/COX6A1/NDUFS8/NDUFA7/TUBB3/NDUFA4/PPIF/TUBA1A/PSMB6/IL1B/XBP1/VDAC1/SDHB/SLC39A6/NDUFB8/NDUFB9/COX5B/COX6C/CALM2/APOE/TUBB2A/CYC1/NDUFV2/NDUFS7/PSMD14/FAS/CDK5/COX7A2/NDUFA9/NDUFS6/PSMA1/PSMB7/NDUFB3/PSMD9/PIK3R2/SDHC/NDUFAB1/PSMC3/EIF2S1/PSMB2/ATP2A2/SLC39A8/PLCB3/CALM3/PSMA5/NCSTN/ARAF/UQCR10/UQCRC1/HRAS/KIF5A/COX5A/SLC25A5/BID/NDUFB6/SLC39A1/PPP3CA	6.11419347855599
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	73/1181	308/9376	1.88165433212004	SOD2/TGM2/MT-ND4/MT-CO2/GPX1/NDUFS5/TUBB/MT-ATP6/TUBA1B/PSMB3/NDUFA13/MAP3K5/POLR2L/TUBB4B/NDUFA11/TUBA1C/TUBB6/UQCR11/PSMA2/CYCS/PSMA4/NDUFV1/UQCRQ/COX7B/PSMA3/GRIA3/COX6A1/NDUFS8/POLR2F/NDUFA7/POLR2E/TUBB3/NDUFA4/PPIF/TUBA1A/PSMB6/VDAC1/SDHB/NDUFB8/NDUFB9/TP53/COX5B/COX6C/TUBB2A/GPX3/CYC1/NDUFV2/NDUFS7/PSMD14/TAF4B/COX7A2/NDUFA9/NDUFS6/PSMA1/PSMB7/NDUFB3/PSMD9/POLR2H/POLR2K/DCTN6/SDHC/NDUFAB1/PSMC3/PSMB2/PPARGC1A/PLCB3/PSMA5/UQCR10/UQCRC1/KIF5A/COX5A/SLC25A5/NDUFB6	5.97247109254034
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	101/1181	480/9376	1.67050522156365	MT-ND4/MT-CO2/GPX1/RPS27A/NDUFS5/TUBB/UBE2L6/MT-ATP6/TUBA1B/PSMB3/NDUFA13/MAP3K5/DKK1/TUBB4B/NDUFA11/TUBA1C/TUBB6/CACNA1C/TNFRSF1A/UQCR11/WNT5B/PSMA2/CYCS/PSMA4/NDUFV1/WNT4/UQCRQ/COX7B/HSD17B10/PSMA3/MAPK3/HSPA5/GRIA3/COX6A1/NDUFS8/PRNP/NDUFA7/UBB/TUBB3/NDUFA4/PPIF/SIGMAR1/TUBA1A/PSMB6/IL1B/XBP1/VDAC1/SDHB/NDUFB8/UBC/UBA52/NDUFB9/COX5B/COX6C/PARK7/CALM2/TUBB2A/GPX3/CYC1/NDUFV2/NDUFS7/OPTN/PSMD14/FAS/TRAP1/CDK5/DERL1/TOMM40/COX7A2/NDUFA9/NDUFS6/PSMA1/PSMB7/NDUFB3/PSMD9/DCTN6/SDHC/NDUFAB1/MAP2K3/PSMC3/NEFH/EIF2S1/PSMB2/MAPK12/ATP2A2/TANK/PLCB3/CALM3/UBE2G2/PSMA5/ARAF/UQCR10/UQCRC1/HRAS/KIF5A/COX5A/SLC25A5/BID/C9orf72/NDUFB6/PPP3CA	5.7248156205891
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	59/1181	235/9376	1.99320446069865	ACTB/RPS6/MT-ND4/MT-CO2/NDUFS5/MT-ATP6/NDUFA13/MAP3K5/ACTG1/NDUFA11/NPR1/UQCR11/NDUFV1/UQCRQ/COX7B/ADCY1/COX6A1/NDUFS8/NDUFA7/COA4/NDUFA4/ADCY3/SDHB/NDUFB8/NDUFB9/COX5B/COX6C/RHEB/NDUFAF8/PNPLA2/CYC1/NDUFV2/NDUFS7/COX7A2/MLST8/NDUFA9/NDUFS6/NDUFB3/SDHC/NDUFAB1/MAP2K3/ACSL1/SMARCD3/ACTL6A/NDUFAF4/NDUFAF2/MAPK12/AKT1S1/PPARGC1A/ACSL5/UQCR10/UQCRC1/HRAS/RPS6KB2/COX5A/COA3/SMARCD2/NDUFB6/DPF3	5.85344909887291
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	19/1181	46/9376	3.27916651327173	PSME2/PSME1/PSMB3/PSMB9/PSMB8/PSMA2/PSMA4/PSMA3/POMP/PSMB6/PSMD14/PSMA1/PSMB7/PSMD9/PSMC3/PSMB2/PSME3/PSMA5/PSMF1	5.8823418182335
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	27/1181	82/9376	2.61407240660044	HLA-C/B2M/HLA-B/HSPA1B/HSPA1A/PSME2/HLA-A/CALR/PSME1/HSP90AA1/HSPA8/TAP2/HSPA5/HLA-F/CTSS/PDIA3/TAP1/CTSB/CTSL/CD4/LGMN/RFX5/HLA-DPA1/TAPBP/PSME3/HLA-DOB/HLA-DQB1	5.57268780136681
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	57/1181	248/9376	1.8246974952883	ACTB/RPS3/MYL9/PFN1/FOS/JUN/HSP90AA1/TUBB/TUBA1B/MYC/GAPDH/ACTG1/TXN/TUBB4B/NFKBIA/TUBA1C/TUBB6/TNFRSF1A/CYCS/MYD88/MAPK3/MYL12A/TUBB3/TUBA1A/IL1B/CASP4/GSDMD/HSP90B1/FLNA/CASP1/CXCL8/TUBB2A/CDC42/ARPC1B/ARPC2/SKP1/IRAK1/ARPC4/AHNAK2/ELMO1/RRAS/DCTN6/MAP2K3/DYNLT1/MYL12B/TLR4/RAB7A/MAPK12/RHOB/M6PR/RAB9A/RIPK2/HRAS/KIF5A/ARPC5/NOD1/TNFRSF10B	4.996533554882
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	37/1181	138/9376	2.12858177177288	MT-ND4/MT-CO2/NDUFS5/MT-ATP6/NDUFA13/NDUFA11/PPA1/UQCR11/CYCS/NDUFV1/UQCRQ/COX7B/COX6A1/NDUFS8/NDUFA7/NDUFA4/SDHB/NDUFB8/NDUFB9/COX5B/COX6C/PPA2/CYC1/NDUFV2/NDUFS7/COX7A2/NDUFA9/NDUFS6/NDUFB3/SDHC/NDUFAB1/ATP6V1B2/UQCR10/UQCRC1/COX5A/LHPP/NDUFB6	5.07013710807399
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	24/1181	75/9376	2.54049110922947	ASS1/ALDOA/TPI1/ENO1/GAPDH/PKM/PGK1/PC/SHMT2/BCAT2/PRPS2/GLUL/PGAM1/PRPS1/PFKL/PFKM/ASL/TALDO1/RPIA/TKT/BCAT1/PYCR3/ASNS/PYCR2	5.08465058483787
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	18/1181	48/9376	2.97713801862828	AOX1/BCAT2/HSD17B10/HIBADH/ECHS1/ALDH6A1/HADH/AACS/DLD/BCKDHA/ALDH9A1/ALDH2/BCAT1/OXCT2/BCKDHB/MCCC1/ACAT1/PCCB	5.21314068621104
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	46/1181	196/9376	1.86324284159049	C3/HLA-C/HLA-B/FOS/HLA-A/RPS27A/JUN/ZFP36/MYC/NFKBIA/TNFRSF1A/CLEC2B/MAPKAPK2/CXCL2/GNG4/CYCS/HIF1A/MAPK3/UBB/HLA-F/UBC/UBA52/TP53/CDK4/CALM2/CXCL8/FAS/CCR1/GNB2/PIK3R2/IFNAR2/ICAM1/MAPK12/CALM3/TICAM1/CXCL3/IFNGR1/HRAS/GNG10/LYN/MICB/STAT2/BID/TLR3/PPP3CA/GNG12	4.63634546496102
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	51/1181	227/9376	1.78365978208567	SOD2/MT-ND4/MT-CO2/FOS/MGST1/NDUFS5/JUN/MT-ATP6/NDUFA13/MAP3K5/NDUFA11/NFKBIA/UQCR11/NDUFV1/UQCRQ/COX7B/HIF1A/MAPK3/HGF/COX6A1/NDUFS8/NDUFA7/NDUFA4/PPIF/VDAC1/GSTT2B/SDHB/NDUFB8/NDUFB9/COX5B/COX6C/NFE2L2/CYC1/NDUFV2/NDUFS7/COX7A2/NDUFA9/NDUFS6/NDUFB3/PIK3R2/SDHC/NDUFAB1/GSTO1/MAPK12/ARAF/UQCR10/UQCRC1/HRAS/COX5A/SLC25A5/NDUFB6	4.5372194164897
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	49/1181	216/9376	1.80098472731834	SOD2/HSPA1B/HSPA1A/FOS/JUN/HSP90AA1/LDLR/MAP3K5/HSPD1/NFKBIA/HSPA8/TNFRSF1A/VCAM1/CXCL2/CYCS/MYD88/MAPK3/HSPA5/ERO1A/IL1B/XBP1/TP53/NFE2L2/HSP90B1/CALM2/CASP1/CXCL8/CDC42/LBP/FAS/IRAK1/PIK3R2/CCL2/CD40/MAP2K3/ICAM1/TLR4/EIF2S1/MAPK12/TANK/PLCB3/CALM3/TICAM1/CXCL3/HRAS/LYN/BID/PPP3CA/TNFRSF10B	4.52105179066049
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	42/1181	180/9376	1.85244143381315	C3/HLA-C/B2M/HLA-B/PILRA/HLA-A/CALR/NFKBIA/TNFRSF1A/IFNGR2/EIF4EBP1/CYCS/TAP2/MYD88/TNFRSF14/CARD9/HLA-F/SRSF3/TNFSF14/IL1B/PDIA3/TP53/RHEB/TAP1/ALYREF/FAS/IRAK1/PIK3R2/IFNAR2/CCL2/NECTIN2/HLA-DPA1/EIF2S1/TAPBP/HLA-DOB/TICAM1/IFNGR1/OAS2/HLA-DQB1/STAT2/BID/TLR3	4.38366572951375
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	30/1181	116/9376	2.05319863353675	ALDOA/TPI1/ENO1/GAPDH/PKM/PGK1/MDH2/PC/ADH5/SHMT2/SDHB/PRPS2/ECHS1/PGAM1/H6PD/ALDH6A1/PRPS1/FH/GPI/PFKL/DLD/PFKM/HK2/SDHC/TALDO1/RPIA/TKT/ACAT1/PGLS/PCCB	4.33281250693134
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	61/1181	300/9376	1.61427039232289	JUND/HSPA1B/INSR/HSPA1A/FOS/JUN/DUSP1/HSPB1/MYC/MAP3K5/IGF2/GADD45A/RASGRP2/MAP3K8/NR4A1/FGF7/CACNA1C/HSPA8/TNFRSF1A/MAPKAPK2/MYD88/ECSIT/MAPK3/HGF/IL1B/EFNA5/RPS6KA4/TP53/SRF/VEGFB/FGF10/FLNA/VEGFC/CDC42/FAS/TGFBR2/IRAK1/NFKB2/CDC25B/NTRK1/RRAS/MAP3K6/MAP2K3/RELB/GNA12/MAPK12/NGF/DUSP8/KDR/DUSP4/MRAS/NRTN/ARAF/HRAS/IL1RAP/DUSP2/CACNB2/DUSP3/FLT3LG/PPP3CA/GNG12	4.10496137215561
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	18/1181	56/9376	2.55183258739567	C3/HSPA1B/HSPA1A/EEF1A1/HSPD1/NFKBIA/HSPA8/CXCL2/CYCS/MYD88/IL1B/EEF1G/CASP1/CXCL8/NFKB2/TLR4/HSF1/CXCL3	4.42147356578662
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	45/1181	205/9376	1.74271493773363	MT-ND4/MT-CO2/INSR/NDUFS5/MT-ATP6/NDUFA13/GAPDH/NDUFA11/UQCR11/NDUFV1/UQCRQ/COX7B/COX6A1/NDUFS8/NDUFA7/NDUFA4/PPIF/VDAC1/SDHB/NDUFB8/NDUFB9/COX5B/COX6C/CYC1/NDUFV2/NDUFS7/TGFBR2/COX7A2/NDUFA9/NDUFS6/GYS1/NDUFB3/PIK3R2/SDHC/NDUFAB1/MAPK12/ACE/ATP2A2/PLCB3/UQCR10/UQCRC1/GFPT2/COX5A/SLC25A5/NDUFB6	4.08156625366007
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	36/1181	155/9376	1.84390483734397	C3/HLA-C/C1R/ACTB/HLA-B/HLA-A/THBS2/CALR/TUBB/COLEC11/TUBA1B/ACTG1/TUBB4B/TUBA1C/TUBB6/TAP2/HLA-F/TUBB3/TUBA1A/CTSS/SEC61G/THBS1/TAP1/TUBB2A/ITGB5/CTSL/HLA-DPA1/TLR4/RAB7A/HLA-DOB/M6PR/ATP6V1B2/HLA-DQB1/SCARB1/STX12/TFRC	4.02166991619437
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	48/1181	227/9376	1.67873861843357	HLA-C/B2M/HLA-B/HLA-A/CALR/CXCL12/MYC/NFKBIA/TNFRSF1A/EIF4EBP1/GNG4/CYCS/TAP2/ADCY1/MAPK3/AKAP13/HLA-F/ADCY3/IL1B/PTGER3/PDIA3/TP53/CDK4/RHEB/CALM2/CXCL8/TAP1/FAS/CCL4L2/CCR1/GNB2/PIK3R2/CCL2/CCL4/GNA12/MAPK12/CDKN2A/PTGER2/PLCB3/TAPBP/CALM3/IL10RB/HRAS/GNG10/RPS6KB2/BID/PPP3CA/GNG12	3.92974873622075
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	38/1181	174/9376	1.73381217943103	HSPA1B/HSPA1A/CALR/HSP90AA1/HSPH1/MAP3K5/DNAJB1/HSPA8/PPP1R15A/PDIA6/HSPA5/UBE2D3/DNAJA1/ERO1A/TXNDC5/SSR4/XBP1/PDIA3/NFE2L2/HSP90B1/SEC61G/RAD23A/DNAJB11/HSPBP1/PDIA4/SKP1/DERL1/EDEM2/DDOST/CRYAB/EIF2S1/MAN1C1/UBE2G2/UBQLN4/DERL2/BCAP31/UBXN8/EDEM1	3.70898035802351
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	21/1181	78/9376	2.13743242363056	C3/SERPING1/C1R/FOS/C1S/CFL1/JUN/C2/MYD88/MAPK3/CFL2/IL1B/CALM2/CASP1/CXCL8/IRAK1/TLR4/MAPK12/CALM3/TICAM1/NOD1	3.82925459842262
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	32/1181	142/9376	1.78907824593624	ACTB/ASS1/FOS/MGST1/JUN/HSP90AA1/DUSP1/MAP3K5/ACTG1/TXN/TNFRSF1A/CAV1/VCAM1/GSTP1/SDC2/IL1B/GSTT2B/TP53/NFE2L2/HSP90B1/CALM2/CAV2/CTSL/PIK3R2/CCL2/ICAM1/GSTO1/SUMO3/MAPK12/KDR/BMP4/CALM3	3.5967099440443
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	34/1181	154/9376	1.75277389841319	DHRS3/NME1/MTHFD2/SHMT2/BCAT2/MTHFD1/FPGS/PTS/COQ2/MTHFD1L/ADSL/CTPS1/AK6/AFMID/HMBS/GGH/DLD/GSS/PNPO/NME2/MOCS2/CPOX/EARS2/ALDH2/RFK/SPR/COQ3/NADSYN1/BCAT1/NFS1/DHODH/UROS/BCO1/CAD	3.57559615457929
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	45/1181	224/9376	1.59489536712229	HLA-C/B2M/HLA-B/TSPO/IL15/FOS/HLA-A/EGR1/CALR/JUN/RAN/ZFP36/MYC/IL15RA/NFKBIA/TNFRSF1A/ADCY1/MAPK3/RANBP1/HLA-F/ADCY3/CHEK2/VDAC1/TP53/SRF/CDK4/TGFBR2/NFKB2/PIK3R2/ANAPC11/NRP1/CD4/CD40/ICAM1/HLA-DPA1/ANAPC15/RELB/CDKN2A/HLA-DOB/CDC26/HRAS/HLA-DQB1/SLC25A5/STAT5A/PPP3CA	3.42091826841056
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	11/1181	31/9376	2.81707683483106	ALDOA/PRPS2/H6PD/PRPS1/GPI/PFKL/PFKM/TALDO1/RPIA/TKT/PGLS	3.84680873814674
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	34/1181	157/9376	1.71928140353905	HLA-C/HLA-B/HLA-A/MYC/GADD45A/SERPINE1/IGFBP3/EIF4EBP1/MAPKAPK2/MAPK3/FOXO1/HLA-F/CHEK2/VDAC1/TP53/CDK4/RHEB/CALM2/CXCL8/TGFBR2/PIK3R2/RRAS/E2F4/MAP2K3/MAPK12/CDKN2A/HIPK3/CALM3/MRAS/HRAS/SLC25A5/E2F5/PPP3CA/CCNB1	3.45018878283133
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	41/1181	200/9376	1.62750211685013	ACTB/RPS3/FOS/JUN/TUBB/TUBA1B/GAPDH/ACTG1/TUBB4B/NFKBIA/TUBA1C/F2R/TUBB6/TNFRSF1A/CYCS/MYD88/NFKBIB/MAPK3/TUBB3/TUBA1A/CLDN10/IL1B/CASP4/ABCF2/CASP1/CXCL8/TUBB2A/CDC42/ARPC1B/ARPC2/FAS/IRAK1/ARPC4/CTTN/TLR4/GNA12/MAPK12/LPAR1/ARPC5/CLDN23/TNFRSF10B	3.4051762735178
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	25/1181	105/9376	1.89024636103383	CXCL12/GADD45A/NFKBIA/TNFRSF1A/VCAM1/CXCL2/MYD88/TNFSF14/IL1B/CXCL8/LBP/CCL4L2/IRAK1/NFKB2/TNFAIP3/CD40/ICAM1/TLR4/RELB/CCL4/CCL13/TICAM1/CXCL3/TRIM25/LYN	3.48239214210525
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	18/1181	67/9376	2.13287499842026	LDHA/ALDOA/TPI1/ENO1/GAPDH/PKM/PGK1/LDHB/ADH5/PGAM1/GPI/PFKL/DLD/PFKM/HK2/ALDH9A1/ADH1C/ALDH2	3.53267745425365
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	49/1181	253/9376	1.53759960909392	C3/ACTB/MYL9/PFN1/RPS27A/JUN/ACTG1/NFKBIA/TNFRSF1A/CYCS/MYD88/NFKBIB/MAPK3/FOXO1/UBE2D3/UBB/MYL12A/IL1B/CASP4/VDAC1/UBC/UBA52/UBE2N/TP53/CASP1/CXCL8/ACTN1/CDC42/PLCE1/ARPC1B/ARPC2/SKP1/ARPC4/PIK3R2/ELMO1/PLCD1/HK2/CTTN/MYL12B/TLR4/MAPK12/AKT1S1/PLCB3/RIPK2/CBX3/ARPC5/RPS6KB2/ACTN4/NOD1	3.2906862419789
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	36/1181	173/9376	1.65205346698448	ACTB/ACTG1/DNAJB1/NFKBIA/TNFRSF1A/IFNGR2/CYCS/MYD88/NFKBIB/MAPK3/IL1B/VDAC1/CDK4/CASP1/CXCL8/FAS/NXT1/PIK3R2/IFNAR2/CCL2/ICAM1/HLA-DPA1/TLR4/EIF2S1/HLA-DOB/TICAM1/IFNGR1/OAS2/TRIM25/HLA-DQB1/MX2/SLC25A5/STAT2/BID/TLR3/TNFRSF10B	3.28607640467041
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	21/1181	85/9376	1.96140857697863	IMPDH2/NME1/GUK1/APRT/TYMP/ITPA/NTPCR/IMPDH1/HPRT1/UCK2/ADSL/CTPS1/AK6/ENPP1/NUDT16/NME2/ADA/DTYMK/PNP/DCTPP1/DCTD	3.38004383935404
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	41/1181	205/9376	1.58780694326842	HLA-C/B2M/HLA-B/HLA-A/CALR/JUN/MYC/GADD45A/NFKBIA/CYCS/TAP2/MYD88/ISG15/NFKBIB/HLA-F/PDIA3/TP53/CDK4/TAP1/PSMD14/FAS/IRAK1/NFKB2/PIK3R2/IFNAR2/TNFAIP3/CD40/MAP2K3/ICAM1/HLA-DPA1/PSMC3/RELB/MAPK12/TAPBP/HLA-DOB/OAS2/HLA-DQB1/LYN/NFKBIE/STAT2/BID	3.23027431040023
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	24/1181	103/9376	1.84987216691466	C3/FOS/CALR/JUN/NFKBIA/SERPINE1/TNFRSF1A/IFNGR2/MYD88/ADCY1/MAPK3/IL1B/CXCL8/FAS/TGFBR2/IRAK1/PIK3R2/CCL2/TLR4/MAPK12/ACE/PLCB3/TICAM1/IFNGR1	3.29229086485459
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	19/1181	75/9376	2.01122212813999	GADD45A/RPRM/SERPINE1/IGFBP3/CYCS/STEAP3/CHEK2/TP53/CDK4/THBS1/FAS/EI24/CDKN2A/SHISA5/ZMAT3/BID/TNFRSF10B/CCNG1/CCNB1	3.3377090944847
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	25/1181	110/9376	1.80432607189593	RPS6/LDHA/INSR/ALDOA/ENO1/GAPDH/TIMP1/EPAS1/PGK1/SERPINE1/ELOB/IFNGR2/LDHB/EIF4EBP1/HIF1A/MAPK3/EIF4E/PFKL/PIK3R2/PFKM/HK2/TLR4/IFNGR1/RPS6KB2/TFRC	3.22120562723535
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	25/1181	110/9376	1.80432607189593	ID2/DCN/MYC/ID4/ID1/CHRD/FST/MAPK3/ID3/THBS1/RGMB/TGFBR2/SKP1/TMEM53/E2F4/BMP4/GREM2/TGIF1/BAMBI/RPS6KB2/SMAD6/TFDP1/TFRC/E2F5/NBL1	3.22120562723535
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	28/1181	128/9376	1.73666384419983	IMPDH2/NME1/GUK1/APRT/NPR1/ITPA/NTPCR/FHIT/IMPDH1/ADCY1/PAICS/HPRT1/ADCY3/PRPS2/ADSL/NUDT5/PFAS/AK6/ENPP1/ATIC/PRPS1/NUDT16/NME2/ADA/PDE3B/PNP/PDE4B/HDDC3	3.18556548598288
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	14/1181	50/9376	2.22292972057578	THBS2/VCAM1/MYD88/CD81/HGF/SDC2/IL1B/CXCL8/THBS1/CCL2/CD40/ICAM1/TLR4/GYPC	3.29135634334128
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	23/1181	101/9376	1.80789899481057	EGR1/JUN/PIM1/SERPINE1/VCAM1/MAPK3/FOXO1/IL1B/VEGFB/CDK4/CXCL8/VEGFC/CDC42/PLCE1/TGFBR2/PIK3R2/PLCD1/CCL2/ICAM1/MAPK12/PLCB3/HRAS/STAT5A	3.09882394804865
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	29/1181	137/9376	1.68052559688993	ACTB/FOS/MCL1/CTSC/JUN/TUBA1B/MAP3K5/GADD45A/ACTG1/NFKBIA/TUBA1C/TNFRSF1A/CYCS/MAPK3/ENDOG/TUBA1A/CTSS/TP53/FAS/CTSB/CTSL/PIK3R2/NTRK1/EIF2S1/NGF/LMNB2/HRAS/BID/TNFRSF10B	3.04598929870175
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	37/1181	187/9376	1.57082505082704	NAMPT/JUN/HSP90AA1/IFI16/GBP1/TXN/NFKBIA/GBP2/CXCL2/MYD88/NFKBIB/MAPK3/CARD9/IL1B/CASP4/GSDMD/VDAC1/CASP1/CXCL8/GABARAP/CTSB/IFNAR2/ANTXR2/CCL2/TNFAIP3/GBP3/TLR4/GABARAPL1/MAPK12/TANK/PLCB3/TICAM1/CXCL3/RIPK2/OAS2/STAT2/NOD1	2.99313158300236
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	41/1181	214/9376	1.52103001574778	HLA-C/B2M/HLA-B/FOS/HLA-A/CALR/CFL1/JUN/NFKBIA/ELOB/TNFRSF1A/GNG4/CYCS/TAP2/MYD88/MAPK3/CFL2/HLA-F/PDIA3/CALM2/TAP1/LIMK2/FAS/SKP1/IRAK1/GNB2/PIK3R2/CD4/MAP2K3/TLR4/MAPK12/TAPBP/CALM3/HRAS/GNG10/RPS6KB2/BID/PPP3CA/GNG12/CCNB1/DCAF1	2.92691826003747
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	24/1181	109/9376	1.74804434121294	FOS/JUN/HSP90AA1/NFKBIA/IFNGR2/NFKBIB/HIF1A/MAPK3/RORA/IL1B/TGFBR2/CD4/RUNX1/RARA/HLA-DPA1/MAPK12/HLA-DOB/IFNGR1/HLA-DQB1/IL1RAP/STAT6/NFKBIE/STAT5A/PPP3CA	2.98199641814156
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	12/1181	42/9376	2.26829563324059	AOX1/MAOB/ECHS1/GCDH/AFMID/HADH/DLD/ALDH9A1/ALDH2/DHTKD1/ACAT1/KYAT1	3.12714019725792
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	12/1181	42/9376	2.26829563324059	SLC39A14/PRNP/STEAP3/TP53/LPCAT3/GSS/ACSL1/GPX4/SLC39A8/ACSL5/SAT1/TFRC	3.12714019725792
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	39/1181	204/9376	1.51775663694775	ACTB/RPS6/DCN/LUM/MYC/IGF2/ACTG1/WNT5B/CAV1/TIMP3/WNT4/HIF1A/HSPG2/MAPK3/HGF/SDC2/TWIST1/TP53/FLNA/THBS1/CAV2/CDC42/PLCE1/FAS/TFAP4/ITGB5/CTSL/TWIST2/PIK3R2/RRAS/CTTN/TLR4/MAPK12/KDR/MRAS/ARAF/HRAS/HPSE/RPS6KB2	2.83821207509783
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	23/1181	105/9376	1.73902665215112	JUN/NFKBIA/MAPKAPK2/MAPK3/CARD9/IL1B/CBLB/BCL3/CALM2/CASP1/NFKB2/PIK3R2/RRAS/KSR1/EGR3/PLK3/RELB/MAPK12/CALM3/MRAS/HRAS/STAT2/PPP3CA	2.8908633822089
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	17/1181	70/9376	1.92805128825451	HLA-C/ACTB/HLA-B/HLA-A/ACTG1/CD55/CAV1/CYCS/HLA-F/SNTB1/CD40/ICAM1/HLA-DPA1/HLA-DOB/HLA-DQB1/BID/SGCE	2.9585273053334
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	9/1181	28/9376	2.55183258739567	PPT1/ELOVL3/ECHS1/HACD1/ELOVL1/HADH/MECR/ACOT7/ACOT2	3.1217681067357
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	20/1181	88/9376	1.80432607189593	C3/SERPING1/C1R/CFD/C1S/C2/CD55/SERPINE1/PROS1/F2R/PROCR/CD59/A2M/CFI/F2RL2/CLU/MASP1/F12/CFH/CFB	2.87771968221338
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	30/1181	149/9376	1.59846336570646	MT-ND4/GABRA2/NDUFS5/NDUFA13/NDUFA11/CACNA1C/GABRE/GNG4/NDUFV1/ADCY1/MAPK3/GRIA3/NDUFS8/NDUFA7/NDUFA4/ADCY3/NDUFB8/NDUFB9/NDUFV2/NDUFS7/NDUFA9/NDUFS6/GNB2/NDUFB3/NDUFAB1/MAPK12/PLCB3/GNG10/NDUFB6/GNG12	2.79535231648725
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	24/1181	112/9376	1.70122172493045	HSPA1B/HSPA1A/LDLR/LAMA4/NFKBIA/HSPA8/TNFRSF1A/IFNGR2/CYCS/MYD88/NFKBIB/LAMC1/MAPK3/PPIF/IRAK1/CD40/MAP2K3/HLA-DPA1/TLR4/MAPK12/HLA-DOB/IL10RB/IFNGR1/HLA-DQB1	2.83400889449107
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	14/1181	54/9376	2.05826825979239	LDHA/AHCY/ADI1/SRM/MDH2/LDHB/AMD1/BCAT2/CISD1/TST/GSS/BCAT1/ENOPH1/KYAT1	2.96056233318714
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	19/1181	83/9376	1.81736939289758	IFI16/POLR2L/GSDME/NFKBIA/NFKBIB/POLR2F/POLR2E/IL1B/GSDMD/CASP1/CCL4L2/POLR2H/POLR2K/POLR3K/POLR3H/CCL4/DDX41/POLR1C/DNASE2	2.83932794485655
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	14/1181	56/9376	1.98475867908552	ALG3/DPAGT1/B4GALT3/ALG13/SRD5A3/ALG1/DDOST/DPM2/MAN1C1/ST6GAL2/ALG8/B4GALT1/MGAT2/DOLPP1	2.80576945195018
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	15/1181	62/9376	1.92073420556663	SOD2/HSPA1B/INSR/HSPA1A/IRS2/HSPA8/ADCY1/FOXO1/ADCY3/CLPB/PIK3R2/CRYAB/AKT1S1/HRAS/RPS6KB2	2.76120158258476
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	19/1181	87/9376	1.73381217943103	MT-CO2/TPM2/SLC8A1/CACNA1C/UQCR11/UQCRQ/COX7B/COX6A1/ATP1B3/COX5B/COX6C/CYC1/COX7A2/ATP2A2/TPM1/UQCR10/UQCRC1/COX5A/CACNB2	2.61033453151837
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	12/1181	47/9376	2.02698758715117	LDHA/PKM/MDH2/PC/LDHB/ADH5/FH/DLD/ALDH9A1/ADH1C/ALDH2/ACAT1	2.67936996624648
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	24/1181	119/9376	1.60114985875807	IL15/FOS/JUN/MAP3K5/MAP3K8/NFKBIA/JUNB/TNFRSF1A/VCAM1/CXCL2/CEBPB/MAPK3/IL1B/RPS6KA4/BCL3/VEGFC/FAS/PIK3R2/CCL2/TNFAIP3/MAP2K3/ICAM1/MAPK12/CXCL3	2.50528539312113
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	14/1181	59/9376	1.88383874625066	GPX1/MGST1/GGT5/SRM/GSTK1/GSTP1/LAP3/GGCT/GSTT2B/GPX3/GSS/GPX4/GSTO1/CHAC2	2.5852175924042
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	19/1181	90/9376	1.67601844011666	FOS/JUN/NFKBIA/IFNGR2/MYD88/NFKBIB/HIF1A/MAPK3/PIK3R2/CD4/MAP2K3/TLR4/MAPK12/TICAM1/IFNGR1/HRAS/RPS6KB2/NFKBIE/PPP3CA	2.44625409513341
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	17/1181	78/9376	1.73030243817712	ENO1/PABPC1/HSPD1/MPHOSPH6/EXOSC5/EXOSC4/LSM4/LSM7/PABPC4/LSM5/NUDT16/PFKL/PFKM/HSPA9/LSM6/LSM2/EXOSC3	2.45861988064558
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	17/1181	78/9376	1.73030243817712	C3/FOS/JUN/EEF1A1/NFKBIA/IFNGR2/MYD88/NFKBIB/MAPK3/IL1B/IRAK1/HLA-DPA1/TLR4/MAPK12/HLA-DOB/IFNGR1/HLA-DQB1	2.45861988064558
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	22/1181	109/9376	1.60237397944519	FOS/JUN/MAP3K8/NFKBIA/MYD88/MAPK3/IL1B/CXCL8/LBP/CCL4L2/IRAK1/PIK3R2/IFNAR2/CD40/MAP2K3/TLR4/CCL4/MAPK12/TICAM1/TOLLIP/STAT2/TLR3	2.40129755700661
Human Diseases	Infectious disease: viral	hsa05162	Measles	26/1181	136/9376	1.51775663694775	HSPA1B/HSPA1A/FOS/JUN/NFKBIA/HSPA8/CYCS/MYD88/NFKBIB/IL1B/CBLB/TP53/CDK4/FAS/IRAK1/PIK3R2/IFNAR2/TNFAIP3/TLR4/EIF2S1/RAB9A/OAS2/MX2/STAT2/BID/STAT5A	2.30884751439291
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	21/1181	105/9376	1.58780694326842	RPS27A/JUN/HIF1A/UBB/CITED2/UBC/UBA52/PHB2/TP53/MTX1/GABARAP/OPTN/TOMM40/RRAS/EIF2S1/RAB7A/GABARAPL1/MRAS/MTX2/HRAS/MON1A	2.29933462231255
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	27/1181	144/9376	1.48856900931414	KCND3/PSMB3/MAP3K5/PSMA2/CYCS/PSMA4/PSMA3/GRIA3/RORA/PPIF/PSMB6/XBP1/VDAC1/PSMD14/PSMA1/PSMB7/PSMD9/PIK3R2/OMA1/PSMC3/ATXN10/PSMB2/ATP2A2/PLCB3/PSMA5/SLC25A5/TWNK	2.24282491402748
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	26/1181	138/9376	1.49576016394851	RPS6/INSR/IRS2/PTPRF/SORBS1/PYGL/EIF4EBP1/MAPK3/FOXO1/FLOT1/CBLB/SHC1/RHEB/CALM2/EIF4E/PHKG1/GYS1/PIK3R2/HK2/PDE3B/PPARGC1A/CALM3/ARAF/FASN/HRAS/RPS6KB2	2.22719528775627
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	37/1181	212/9376	1.38558624766348	ACTB/PFN1/INSR/RASGRP2/ID1/ACTG1/SIPA1L2/FGF7/APBB1IP/F2R/ADCY1/MAPK3/HGF/DOCK4/ADCY3/EFNA5/VEGFB/FGF10/CALM2/THBS1/VEGFC/CDC42/PLCE1/P2RY1/MAGI1/PIK3R2/RRAS/MAP2K3/MAGI3/MAPK12/NGF/KDR/PLCB3/CALM3/MRAS/LPAR1/HRAS	2.15567375456873
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	12/1181	52/9376	1.83208493454048	TSPO/LDLR/STAR/LIPA/VDAC1/APOC1/APOE/SOAT1/NPC2/PLTP/STARD3NL/SCARB1	2.28404316061027
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	10/1181	41/9376	1.93634993081514	MYC/TYMP/MAPK3/TP53/CDK4/CXCL8/THBS1/CDKN2A/ARAF/HRAS	2.28091477277445
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	15/1181	71/9376	1.67726085556523	LDHA/MYC/PKM/LDHB/HIF1A/MAPK3/SLC1A5/TP53/PGAM1/PFKL/PIK3R2/PFKM/HK2/NTRK1/HRAS	2.1745183084968
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	26/1181	144/9376	1.43343682378399	C3/MAP3K5/C2/NFKBIA/TNFRSF1A/ADH5/CXCL2/MYD88/FOXO1/IL1B/CXCL8/LBP/FAS/IRAK1/ADIPOR1/MAP2K3/TLR4/ALDH9A1/MAPK12/ADH1C/ALDH2/PPARGC1A/TICAM1/CXCL3/FASN/IL17RC	1.98973510089055
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	9/1181	37/9376	1.93111655262375	LAMA4/APOL1/VCAM1/MYD88/IL1B/FAS/ICAM1/THOP1/PLCB3	2.1542238492998
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	10/1181	43/9376	1.84628714333537	ADH5/ECHS1/GCDH/HADH/ACSL1/ALDH9A1/ADH1C/ALDH2/ACSL5/ACAT1	2.11143368635085
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	8/1181	32/9376	1.98475867908552	LDHA/LDHB/ECHS1/ALDH6A1/DLD/BCKDHA/BCKDHB/PCCB	2.11823675466599
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	10/1181	44/9376	1.80432607189593	HLA-C/HLA-B/HLA-A/HSPD1/HLA-F/IL1B/FAS/HLA-DPA1/HLA-DOB/HLA-DQB1	2.03005230423723
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	22/1181	120/9376	1.45548969799605	JUN/MAP3K5/NFKBIA/MAPKAPK2/NFKBIB/MAPK3/IRAK3/SHC1/ARHGDIA/TP53/CALM2/CDC42/IRAK1/PIK3R2/NTRK1/MAPK12/NGF/ARHGDIB/CALM3/RIPK2/HRAS/NFKBIE	1.90631039869361
NA	NA	hsa04517	IgSF CAM signaling	48/1181	299/9376	1.27449386750642	ACTB/MYL9/TUBB/TUBA1B/MYL6/PTPRF/ACTG1/TUBB4B/TUBA1C/TUBB6/SORBS1/LRFN4/TJP2/NCAM2/MAPK3/FOXO1/PMP22/MYL12A/TUBB3/TUBA1A/ACTN1/TUBB2A/PPFIA2/MYLK3/CDC42/ARPC1B/NLGN4X/CSK/ARPC2/MAGI1/ARPC4/PIK3R2/NRP1/ICAM1/NECTIN2/PLXNA1/MYL12B/MAPK12/KDR/PVR/CD226/KIRREL1/CNTNAP1/ARPC5/IL1RAP/LYN/ACTN4/KCNA2	1.83118904181484
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	18/1181	94/9376	1.52024069036338	FOSB/JUND/FOS/JUN/HSP90AA1/NFKBIA/CXCL2/CEBPB/MAPK3/IL1B/HSP90B1/CXCL8/CCL2/TNFAIP3/MAPK12/CXCL3/TRAF4/IL17RC	1.92434781080187
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	13/1181	63/9376	1.63821351289599	POLR2L/POLD4/POLR2F/POLD2/POLR2E/RAD23A/RPA3/POLR2H/POLR2K/RPA4/ERCC1/GTF2H3/POLE3	1.92942355657004
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	20/1181	108/9376	1.47019161413742	RAN/EEF1A1/EIF4A3/THOC6/IPO4/ALYREF/NUP35/NXT1/THOC3/MAGOH/RANGAP1/SUMO3/NCBP2/NUP93/XPOT/NDC1/GLE1/SEH1L/TMEM33/MAGOHB	1.86564862532271
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	12/1181	57/9376	1.67137572975623	PPT1/SCP2/ELOVL3/ECHS1/HACD1/ELOVL1/HADH/MECR/ACSL1/ACSL5/FASN/ACAT1	1.92998759445781
Human Diseases	Immune disease	hsa05330	Allograft rejection	9/1181	39/9376	1.83208493454048	HLA-C/HLA-B/HLA-A/HLA-F/FAS/CD40/HLA-DPA1/HLA-DOB/HLA-DQB1	1.97666189860327
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	25/1181	142/9376	1.39771737963769	FOSB/JUND/FOS/JUN/NFKBIA/JUNB/TNFRSF1A/IFNGR2/MAPK3/IL1B/FOSL2/TGFBR2/NFKB2/ACP5/PIK3R2/IFNAR2/TMEM64/RELB/FHL2/MAPK12/ATP2A2/IFNGR1/GAB2/STAT2/PPP3CA	1.81284183365727
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	16/1181	83/9376	1.53041633086112	SOD2/GSTK1/PRDX1/SCP2/ECH1/MPV17/CRAT/MPV17L2/ACSL1/PEX5/NUDT7/PEX10/ACSL5/PEX3/PEX19/PEX16	1.84252789951357
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	29/1181	170/9376	1.35430592219953	YBX3/ACTB/MYL9/JUN/TUBA1B/MYL6/MAP3K5/ACTG1/TUBA1C/TJP2/MYL12A/TUBA1A/CLDN10/CDK4/CD1D/ACTN1/CDC42/ARPC1B/ARPC2/MAGI1/ARPC4/CTTN/RUNX1/MYL12B/ARPC5/RAP2C/AMOTL2/ACTN4/CLDN23	1.76971566462537
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	15/1181	77/9376	1.54656520448222	MYC/GADD45A/NFKBIA/MAPK3/SHC1/TP53/CDK4/TGFBR2/PIK3R2/RUNX1/CDKN2A/ARAF/HRAS/GAB2/STAT5A	1.82812263909448
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	8/1181	34/9376	1.86800816855108	POLR2L/POLR2F/POLR2E/POLR2H/POLR2K/POLR3K/POLR3H/POLR1C	1.92477268704092
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	12/1181	59/9376	1.61471892535771	NME1/TYMP/UCK2/CTPS1/ENPP1/NME2/DTYMK/DCTPP1/DCTD/DPYD/DHODH/CAD	1.79804538662741
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	24/1181	138/9376	1.38070168979862	ACTB/FOS/JUN/ACTG1/NFKBIA/MYD88/MAPK3/IL1B/CASP1/CXCL8/CDC42/ARPC1B/ARPC2/IRAK1/ARPC4/PIK3R2/ELMO1/CCL2/CD4/MAP2K3/TLR4/MAPK12/TICAM1/ARPC5	1.71029677497123
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	30/1181	181/9376	1.31586210768101	C3/HSPD1/TNFRSF1A/IFNGR2/CYCS/CEBPB/MYD88/MAPK3/CARD9/CTSS/IL1B/CALM2/LBP/IRAK1/HSPA9/KSR1/RFX5/PLK3/HLA-DPA1/TLR4/RAB7A/MAPK12/CALM3/HLA-DOB/IL10RB/RIPK2/IFNGR1/HLA-DQB1/BID/PPP3CA	1.62890988082617
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	17/1181	93/9376	1.45122139976146	FOS/JUN/NFKBIA/IFNGR2/NFKBIB/MAPK3/MAF/CD4/HLA-DPA1/MAPK12/HLA-DOB/IFNGR1/HLA-DQB1/STAT6/NFKBIE/STAT5A/PPP3CA	1.66005736405666
NA	NA	hsa04518	Integrin signaling	26/1181	154/9376	1.34035651055126	C3/ACTB/THBS2/LAMA4/ACTG1/TNC/VCAM1/LAMC1/ITGA1/HGF/VEGFB/FLNA/THBS1/VEGFC/ACTN1/CDC42/FERMT1/PARVB/COL6A2/ITGB5/PIK3R2/ICAM1/KDR/PARVA/ACTN4/FERMT2	1.61665731619872
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	8/1181	36/9376	1.76422993696491	POLD4/POLD2/SSBP1/RNASEH2C/RPA3/RNASEH2A/RPA4/POLE3	1.74396581022006
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	19/1181	107/9376	1.40973513654672	LDHA/PKM/PYGL/LDHB/PRMT1/FOXO1/PGAM1/CALM2/PHKG1/PFKL/GYS1/PFKM/SIK1/PDE3B/PPARGC1A/PLCB3/CALM3/PPP4C/PPP3CA	1.61813504573733
Organismal Systems	Digestive system	hsa04978	Mineral absorption	12/1181	61/9376	1.56177732124762	ATOX1/SLC8A1/MT1X/MT2A/STEAP1/ATP1B3/MT1E/CYBRD1/ATP2B3/MT1A/SLC30A1/MT1M	1.67098979981269
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	37/1181	233/9376	1.26070508371097	ACTB/MYL9/TPM2/DCN/THBS2/ENO1/FBLN1/LMOD1/ZYX/FBLN2/ACTG1/SDC3/NID2/DES/HSPG2/ITGA1/SDC2/ATP1B3/SNTB1/THBS1/DIAPH2/SYNPO2/BGN/COL6A2/SYNE2/CAPZB/CSRP1/ITGB5/PDLIM7/FHL3/PKP2/PLEC/FHL2/TPM1/LMNB2/MYOM2/SGCE	1.52974558556125
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	28/1181	170/9376	1.30760571798575	ACTB/MGST1/MYC/IGF2/GADD45A/ACTG1/WNT5B/GSTP1/WNT4/MAPK3/HGF/GSTT2B/SHC1/TP53/CDK4/NFE2L2/TGFBR2/TXNRD2/PIK3R2/SMARCD3/GSTO1/ACTL6A/CDKN2A/ARAF/HRAS/RPS6KB2/SMARCD2/DPF3	1.53645373542798
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	10/1181	49/9376	1.62021116660043	GALNT13/B4GALT3/EOGT/GALNT15/C1GALT1C1/POGLUT1/ST6GAL2/B4GALT1/COLGALT1/C1GALT1C1L	1.65235264857937
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	21/1181	122/9376	1.36655515609167	ACTB/MYC/ACTG1/DIO3/WNT4/HIF1A/MAPK3/FOXO1/ATP1B3/TP53/RHEB/PLCE1/PFKL/PIK3R2/PFKM/PLCD1/ATP2A2/PLCB3/BMP4/HRAS/MED24	1.54700105057376
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	17/1181	95/9376	1.42066937029279	IL15/FOS/JUN/CXCL12/CXCL2/IL1B/CXCL8/CTSL/ACP5/CCL2/ICAM1/HLA-DPA1/TLR4/HLA-DOB/ATP6V1B2/CXCL3/HLA-DQB1	1.56437697684159
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	8/1181	37/9376	1.71654804677667	ASS1/NIT2/GLUL/ADSL/ASL/GFPT2/ASNS/CAD	1.65779986102259
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	8/1181	37/9376	1.71654804677667	GALK1/UAP1/GPI/HK2/GALE/GMDS/GFPT2/UXS1	1.65779986102259
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	15/1181	82/9376	1.45226244811136	IMPDH2/MGST1/NME1/TYMP/GSTP1/ITPA/IMPDH1/HPRT1/CES1/TPMT/UCK2/GSTT2B/NME2/GSTO1/DPYD	1.56146491154925
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	7/1181	31/9376	1.79268525852886	MDH2/SHMT2/GLUL/AFMID/DLD/ACAT1/PCCB	1.67813959248037
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	16/1181	89/9376	1.42724219619633	GJA1/TUBB/TUBA1B/TUBB4B/TUBA1C/HTR2A/TUBB6/ADCY1/MAPK3/TUBB3/ADCY3/TUBA1A/TUBB2A/PLCB3/LPAR1/HRAS	1.53733150517179
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	10/1181	50/9376	1.58780694326842	MAOB/SRM/AMD1/LAP3/ALDH9A1/ALDH2/SAT1/L3HYPDH/PYCR3/PYCR2	1.58200596390417
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	12/1181	63/9376	1.51219708882706	AASS/ECHS1/GCDH/HADH/PLOD2/SMYD3/DLD/ALDH9A1/ALDH2/DHTKD1/ACAT1/COLGALT1	1.54845535047547
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	9/1181	44/9376	1.62389346470634	ALG3/B4GALT3/ALG13/ALG1/DDOST/HEXB/MAN1C1/B4GALT1/MGAT2	1.57465536662291
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	16/1181	90/9376	1.41138394957193	SOD2/INSR/IRS2/EIF4EBP1/ADCY1/FOXO1/ADCY3/TP53/RHEB/EIF4E/ADIPOR1/PIK3R2/AKT1S1/PPARGC1A/HRAS/RPS6KB2	1.48864233812736
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	8/1181	38/9376	1.67137572975623	GALK1/UAP1/GPI/HK2/GALE/HEXB/GFPT2/UXS1	1.57422428930811
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	8/1181	38/9376	1.67137572975623	NNMT/NAMPT/AOX1/ENPP1/PNP/BST1/NADSYN1/CD38	1.57422428930811
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	32/1181	203/9376	1.2514734528224	ACTB/MYL9/THBS2/JUN/LAMA4/ZYX/ACTG1/TNC/CAV1/LAMC1/MAPK3/ITGA1/HGF/MYL12A/SHC1/VEGFB/FLNA/THBS1/CAV2/VEGFC/ACTN1/MYLK3/CDC42/PARVB/COL6A2/ITGB5/PIK3R2/MYL12B/KDR/PARVA/HRAS/ACTN4	1.37505660054389
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	17/1181	98/9376	1.37717949161036	LDLR/NR4A1/NPR1/CACNA1C/STAR/ADCY1/ATP1B3/ADCY3/CALM2/ATP2B3/POMC/NR4A2/KCNK3/PLCB3/CALM3/SCARB1/CAMK1	1.42485290643677
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	9/1181	45/9376	1.58780694326842	HLA-C/HLA-B/HLA-A/HLA-F/IL1B/FAS/HLA-DPA1/HLA-DOB/HLA-DQB1	1.50042047490103
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	14/1181	78/9376	1.42495494908704	ACTB/ACTG1/CAV1/SHC1/CAV2/CDC42/ARPC1B/ARPC2/ARPC4/PIK3R2/ELMO1/CTTN/MAD2L2/ARPC5	1.43064384231281
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	8/1181	39/9376	1.62851994181376	AHCY/MTHFD2/SHMT2/MTHFD1/MTHFD1L/ATIC/MTHFS/DLD	1.49308246060446
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	4/1181	15/9376	2.11707592435789	ST3GAL5/ST6GALNAC6/ST6GALNAC5/HEXB	1.64362715120844
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	5/1181	21/9376	1.89024636103383	CHST11/CHSY3/B3GAT3/B3GALT6/UST	1.55036539680984
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	5/1181	21/9376	1.89024636103383	BCAT2/ENPP1/ALDH2/BCAT1/DPYD	1.55036539680984
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	6/1181	27/9376	1.76422993696491	ECHS1/HADH/AACS/OXCT2/ACAT1/BDH1	1.50959155083879
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	6/1181	27/9376	1.76422993696491	SCP2/ELOVL3/HACD1/ELOVL1/ACOT7/ACOT2	1.50959155083879
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	26/1181	163/9376	1.26634909585825	FOS/JUN/MYC/NFKBIA/CYCS/MYD88/HSPG2/MAPK3/TP53/CXCL8/FAS/TGFBR2/IRAK1/PIK3R2/EGR3/MAP2K3/TLR4/MAPK12/TICAM1/ARAF/HRAS/STAT6/STAT2/BID/STAT5A/TLR3	1.30220872707388
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	25/1181	156/9376	1.272281204542	LDLR/MYC/NFKBIA/TNFRSF1A/CYCS/CD81/MAPK3/CLDN10/TP53/CDK4/FAS/PIK3R2/IFNAR2/EIF2S1/PSME3/TICAM1/ARAF/OAS2/HRAS/MX2/SCARB1/STAT2/BID/CLDN23/TLR3	1.30181901243232
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	3/1181	10/9376	2.38171041490262	ETHE1/TST/SQOR	1.65949543666961
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	6/1181	28/9376	1.70122172493045	FPGS/PTS/GGH/MOCOS/MOCS2/SPR	1.41062356495026
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	5/1181	22/9376	1.80432607189593	MAOB/HNMT/ALDH9A1/ALDH2/CARNMT1	1.43377469805073
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	26/1181	166/9376	1.24346326882466	MYL9/INSR/IRS2/EDNRB/SLC8A1/NPR1/CACNA1C/ADCY1/MAPK3/ATP1B3/PPIF/ADCY3/VDAC1/SRF/CALM2/MYLK3/ATP2B3/PDE3B/GNA12/ATP2A2/PLCB3/CALM3/KCNJ8/SLC25A5/ADRA2A/PPP3CA	1.20141703536574
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	12/1181	68/9376	1.40100612641331	MYC/PIM1/EIF4EBP1/MAPK3/PIK3R2/RUNX1/RARA/ZBTB16/ARAF/HRAS/RPS6KB2/STAT5A	1.25983417398311
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	7/1181	35/9376	1.58780694326842	ALDOA/TPI1/SORD/PFKL/PFKM/HK2/GMDS	1.32253798964552
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	13/1181	75/9376	1.37609935083263	MGST1/MAP3K5/GSTP1/CYCS/MAPK3/GSTT2B/TP53/FAS/PIK3R2/GSTO1/ERCC1/CDKN2A/BID	1.2413793060609
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	35/1181	232/9376	1.19769920289643	ACTB/MYL9/PFN1/CFL1/CXCL12/ACTG1/FGF7/F2R/MAPK3/ITGA1/CFL2/MYL12A/FGF10/RGCC/ACTN1/MYLK3/CDC42/ARPC1B/DIAPH2/LIMK2/ARPC2/ARPC4/ITGB5/PIK3R2/RRAS/MYL12B/GNA12/MRAS/ARAF/LPAR1/HRAS/INSRR/ARPC5/ACTN4/GNG12	1.1574891002771
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	5/1181	23/9376	1.72587711224828	POLD4/POLD2/SSBP1/RPA3/RPA4	1.32308474375243
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	5/1181	23/9376	1.72587711224828	ENPEP/CTSA/NLN/ACE/THOP1	1.32308474375243
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	22/1181	140/9376	1.24756259828233	RPS6/EGR1/SLC8A1/SERPINE1/GNG4/ADCY1/MAPK3/ADCY3/CALM2/ACTA2/MYLK3/GNB2/RRAS/PDE3B/PPARGC1A/PLCB3/CALM3/MRAS/HRAS/GNG10/RPS6KB2/GNG12	1.12032285526497
Genetic Information Processing	Transcription	hsa03040	Spliceosome	36/1181	243/9376	1.17615329130994	HSPA1B/HSPA1A/SNRPB/EIF4A3/HSPA8/SNRPG/TXNL4A/SNRPD1/SNU13/PPIL1/SRSF3/THOC6/PPIH/LSM4/SF3B6/SNRPD2/LSM7/SNRPF/ALYREF/SNRNP40/LSM5/THOC3/PRPF31/MAGOH/PQBP1/PHF5A/NCBP2/SNRPA/LSM6/LSM2/HNRNPM/PRPF19/SNRPE/SNRPB2/MAGOHB/PUF60	1.05614434531736
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	6/1181	30/9376	1.58780694326842	MDH2/PC/SDHB/FH/DLD/SDHC	1.22410468128673
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	6/1181	30/9376	1.58780694326842	PIGU/DPM2/PIGK/PIGN/PIGH/PIGT	1.22410468128673
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	6/1181	30/9376	1.58780694326842	ABCC3/SHMT2/IL1B/FPGS/ATIC/GGH	1.22410468128673
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	16/1181	99/9376	1.28307631779266	HTR2A/ADCY1/ADCY3/IL1B/CALM2/PIK3R2/NTRK1/MAP2K3/ASIC3/MAPK12/NGF/PTGER2/PLCB3/HRH1/CALM3/IL1RAP	1.07486386962524
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	7/1181	37/9376	1.50197954092958	AOX1/MAOB/ADH5/MIF/COMT/ADH1C/GSTZ1	1.16137587274538
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	29/1181	193/9376	1.19291195219648	CXCL12/RASGRP2/NFKBIA/CXCL2/GNG4/CXCL13/NFKBIB/ADCY1/MAPK3/ADCY3/SHC1/CXCL8/CDC42/CCL4L2/CCR1/GNB2/PIK3R2/ELMO1/CCL2/CCL4/CCL13/PLCB3/CXCL3/HRAS/GNG10/LYN/STAT2/CCL26/GNG12	1.02797275952759
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	4/1181	18/9376	1.76422993696491	MECR/ACSL1/ACSL5/FASN	1.231983485853
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	16/1181	100/9376	1.27024555461473	CXCL12/TNFRSF1A/CXCL2/CXCL13/TNFRSF14/TNFSF14/CXCL8/CCL4L2/CCR1/CCL2/CCL4/CCL13/IL10RB/CXCL3/TNFRSF10B/CCL26	1.03136953015402
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	6/1181	31/9376	1.53658736445331	HSPA5/OXA1L/SEC61G/SRP19/IMMP2L/SRPRB	1.13597230606378
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	15/1181	93/9376	1.28048947037776	ACTB/MYL9/INSR/PTPRF/ACTG1/SORBS1/MAPK3/PTPRM/MYL12A/ACTN1/CDC42/TGFBR2/NECTIN2/MYL12B/ACTN4	1.03192936125615
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	11/1181	65/9376	1.34352895199635	LDLR/NR4A1/CACNA1C/STAR/ADCY1/PBX1/ADCY3/POMC/KCNK3/PLCB3/SCARB1	1.05501338003878
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	7/1181	38/9376	1.4624537635367	TAP2/TAP1/UNG/CD4/ADA/CD40/RFX5	1.0843495154431
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	20/1181	130/9376	1.22138995636032	FOS/JUN/EDNRB/NFKBIA/GNG4/ADCY1/MAPK3/ADCY3/SHC1/VEGFB/ACTA2/VEGFC/TGFBR2/GNB2/PIK3R2/MAPK12/PLCB3/HRAS/GNG10/GNG12	0.964914325856752
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	12/1181	73/9376	1.30504680268637	GADD45A/FHIT/MAPK3/HGF/TP53/CDK4/PIK3R2/CDKN2A/ARAF/HRAS/KIF5A/STAT5A	0.993236120610088
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	10/1181	59/9376	1.34559910446476	INSR/IRS2/NPR1/ADCY1/ADCY3/PTGER3/PNPLA2/ABHD5/PIK3R2/PDE3B	1.01087318085062
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	11/1181	66/9376	1.32317245272368	JUN/IFNGR2/RORA/IL1B/MAF/HLA-DPA1/TLR4/HLA-DOB/IFNGR1/HLA-DQB1/STAT6	1.00015559703351
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	24/1181	160/9376	1.19085520745131	HLA-C/HLA-B/HLA-A/PTPRF/SDC3/VCAM1/NCAM2/CDH3/PTPRM/SDC2/HLA-F/CLDN10/NLGN4X/CD4/CD40/ICAM1/NECTIN2/HLA-DPA1/HLA-DOB/PVR/CD226/CNTNAP1/HLA-DQB1/CLDN23	0.924333898582641
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	6/1181	32/9376	1.48856900931414	GALK1/PFKL/PFKM/HK2/GALE/B4GALT1	1.05092227639061
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	4/1181	19/9376	1.67137572975623	IDUA/HYAL3/HEXB/HPSE	1.11201393928147
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	4/1181	19/9376	1.67137572975623	DLD/BCKDHA/DHTKD1/BCKDHB	1.11201393928147
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	10/1181	60/9376	1.32317245272368	HSPB1/MAPKAPK2/SH2D2A/MAPK3/CDC42/PIK3R2/MAPK12/KDR/HRAS/PPP3CA	0.953303807624535
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	16/1181	103/9376	1.23324811127644	HSPB1/LAMA4/PRDX1/CXCL2/LAMC1/ADCY1/IL1B/CXCL8/CD1D/ACTN1/PIK3R2/TLR4/RAB7A/PLCB3/CXCL3/ACTN4	0.903571920454623
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	25/1181	169/9376	1.17441341957723	RPS27A/IRS2/HIF1A/MAPK3/UBB/UBC/UBA52/RHEB/GABARAP/OPTN/CTSB/CTSL/MLST8/PIK3R2/RRAS/EIF2S1/RAB7A/GABARAPL1/AKT1S1/TANK/MRAS/DEPTOR/HRAS/RPS6KB2/C9orf72	0.868560921937663
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	14/1181	89/9376	1.24883692167179	GABRA2/CACNA1C/GABRE/SLC38A2/GNG4/ADCY1/ADCY3/SLC38A5/GLUL/GABARAP/GNB2/GABARAPL1/GNG10/GNG12	0.895381689219236
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	6/1181	33/9376	1.44346085751674	BCAT2/DLD/BCKDHA/DHTKD1/BCAT1/BCKDHB	0.968735457541262
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	9/1181	54/9376	1.32317245272368	HLA-C/HLA-B/HLA-A/HLA-F/FAS/CD40/HLA-DPA1/HLA-DOB/HLA-DQB1	0.904092305333931
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	4/1181	20/9376	1.58780694326842	LIPA/SOAT1/HSD17B7/NSDHL	0.998943007095255
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	4/1181	20/9376	1.58780694326842	UAP1/CYB5R3/CYB5R1/GMDS	0.998943007095255
Human Diseases	Cancer: specific types	hsa05214	Glioma	12/1181	76/9376	1.25353179731717	GADD45A/MAPK3/SHC1/TP53/CDK4/CALM2/PIK3R2/CDKN2A/CALM3/ARAF/HRAS/CAMK1	0.842430079314138
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	23/1181	157/9376	1.16304330239406	CALR/PROS1/MAPKAPK2/CEBPB/HIF1A/BSG/MAPK3/LIPA/PBX1/CASP1/THBS1/MFGE8/ITGB5/ELMO1/ADAM9/SLC16A1/RAB7A/MAPK12/ATP2A2/PTGER2/DUSP8/DUSP4/DUSP2	0.78207245490844
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	3/1181	14/9376	1.70122172493045	CHST2/B4GALT3/B4GALT1	0.996715404020282
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	50/1181	362/9376	1.09655175640084	RPS6/INSR/THBS2/MCL1/HSP90AA1/MYC/LAMA4/IGF2/OSMR/NR4A1/FGF7/F2R/TNC/CSF3R/EIF4EBP1/GNG4/LAMC1/MAPK3/ITGA1/HGF/EFNA5/TP53/VEGFB/CDK4/HSP90B1/FGF10/RHEB/EIF4E/THBS1/VEGFC/MAGI1/COL6A2/ITGB5/MLST8/GNB2/GYS1/CDC37/PIK3R2/IFNAR2/NTRK1/TLR4/NGF/KDR/NRTN/LPAR1/HRAS/GNG10/RPS6KB2/FLT3LG/GNG12	0.711200077055139
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	15/1181	99/9376	1.20288404793062	C3/C1R/CFD/C1S/C2/CFI/MASP1/ICAM1/HLA-DPA1/DEFB1/HLA-DOB/KRT23/HLA-DQB1/CFH/CFB	0.770367279553442
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	11/1181	70/9376	1.24756259828233	JUN/EPAS1/ELOB/HIF1A/MAPK3/HGF/CDC42/FH/PIK3R2/ARAF/HRAS	0.789202834010498
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	35/1181	250/9376	1.11146486028789	CTSC/BLOC1S1/FUCA2/NCOA7/PPT1/CD68/CTSA/LIPA/IDUA/CTSS/AP3S1/PSAP/NEU1/CTSB/CTSL/ACP5/LAMTOR1/MLST8/NPC2/HYAL3/LGMN/LITAF/KXD1/HEXB/LAMTOR5/LAMTOR2/RAB7A/AKT1S1/TPP1/M6PR/ATP6V1B2/DEPTOR/LAMTOR4/TLR3/DNASE2	0.67811578858044
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	11/1181	71/9376	1.22999129408117	JUN/NFKBIA/CXCL2/CXCL8/CDC42/CSK/MAPK12/ATP6V1B2/CXCL3/LYN/NOD1	0.738445571842447
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	13/1181	86/9376	1.20008664316799	ACTB/GJA1/ACTG1/SLC8A1/CACNA1C/DES/ITGA1/SNTB1/ITGB5/PKP2/ATP2A2/CACNB2/SGCE	0.707612628255961
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	20/1181	139/9376	1.14230715343052	HSPA1B/HSPA1A/FOS/JUN/HSP90AA1/HSPA8/ADCY1/MAPK3/ADCY3/FKBP4/SHC1/HSP90B1/CALM2/PIK3R2/POMC/RARA/PLCB3/CALM3/KRT23/HRAS	0.641659705932313
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	6/1181	36/9376	1.32317245272368	PYGL/ENPP1/GPI/GYS1/HK2/GYG1	0.737476616780242
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	8/1181	51/9376	1.24533877903405	ACTB/ACTG1/TJP2/ERO1A/ADCY3/SEC61G/PDIA4/ATP6V1B2	0.666903467462864
Human Diseases	Cancer: specific types	hsa05218	Melanoma	11/1181	73/9376	1.19629290246251	GADD45A/FGF7/MAPK3/HGF/TP53/CDK4/FGF10/PIK3R2/CDKN2A/ARAF/HRAS	0.63913209129946
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	19/1181	133/9376	1.1341478166203	SOD2/INSR/FBXO32/IRS2/GADD45A/PRMT1/MAPK3/FOXO1/HOMER1/GABARAP/TGFBR2/PIK3R2/BCL6/PLK3/GABARAPL1/MAPK12/ARAF/HRAS/CCNB1	0.591478633080683
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	6/1181	37/9376	1.2874110350825	MYC/GADD45A/MAPK3/TP53/NTRK1/HRAS	0.664951884468164
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	4/1181	23/9376	1.38070168979862	ASS1/GLUL/ASL/CAD	0.693919933820759
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	8/1181	52/9376	1.22138995636032	INSR/LDLR/STAR/ADCY1/ADCY3/HSD17B7/ACOT2/SCARB1	0.607707452282921
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	20/1181	142/9376	1.11817390371015	RPS27A/UBE2L6/ELOB/UBE2D3/UBB/CBLB/UBE2S/UBC/UBA52/UBE2N/SKP1/ANAPC11/ANAPC15/UBE2M/MID1/FBXW7/UBE2G2/CDC26/PRPF19/FBXO4	0.538650326237964
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	15/1181	105/9376	1.1341478166203	ACTB/TPM2/ACTG1/SLC8A1/CACNA1C/DES/ADCY1/ITGA1/ADCY3/SNTB1/ITGB5/ATP2A2/TPM1/CACNB2/SGCE	0.524748342623495
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	14/1181	98/9376	1.1341478166203	CFL1/MAPK3/CFL2/CDC42/ARPC1B/LIMK2/ARPC2/ARPC4/PIK3R2/BIN1/ARPC5/GAB2/RPS6KB2/LYN	0.506763783967959
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	5/1181	31/9376	1.28048947037776	ECHS1/ALDH6A1/ALDH9A1/ALDH2/DPYD	0.593805019647184
NA	NA	hsa04981	Folate transport and metabolism	5/1181	31/9376	1.28048947037776	ABCC3/SHMT2/MTHFD1/FPGS/MTHFS	0.593805019647184
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	40/1181	298/9376	1.06564224380431	IL15/CXCL12/IL32/IL15RA/OSMR/TNFRSF1A/IFNGR2/CSF3R/CXCL2/CXCL13/TNFRSF14/TNFSF14/IL1B/CXCL8/IL13RA1/RELT/FAS/CCL4L2/TGFBR2/CCR1/IFNAR2/CLCF1/CCL2/CD4/CD40/THPO/CCL4/NGF/CCL13/BMP4/TNFRSF21/IL10RB/CXCL3/IFNGR1/IL1RAP/IL17RC/IL1RL1/TNFRSF4/TNFRSF10B/CCL26	0.437152099712825
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	3/1181	17/9376	1.40100612641331	HSD3B7/SCP2/SLC27A5	0.628198438800867
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	3/1181	17/9376	1.40100612641331	TXNRD2/SCLY/KYAT1	0.628198438800867
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	14/1181	99/9376	1.12269177806858	FOS/JUN/ADCY1/MAPK3/ADCY3/SHC1/TP53/CDK4/PIK3R2/MAPK12/CDKN2A/ARAF/HRAS/RPS6KB2	0.465870689481646
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	14/1181	99/9376	1.12269177806858	ACTB/TPM2/ACTG1/SLC8A1/CACNA1C/DES/ITGA1/SNTB1/ITGB5/ACE/ATP2A2/TPM1/CACNB2/SGCE	0.465870689481646
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	23/1181	168/9376	1.08689165759445	HSP90AA1/PPIA/TNFRSF1A/IFNGR2/PYGL/IL1B/VDAC1/GLUL/CASP1/FAS/IFNAR2/TNFAIP3/TLR4/TICAM1/IFNGR1/STAT6/CHMP5/SLC25A5/STAT2/BID/STAT5A/TLR3/TNFRSF10B	0.431405994807948
Organismal Systems	Endocrine system	hsa04924	Renin secretion	10/1181	69/9376	1.15058474149885	NPR1/CACNA1C/CALM2/CTSB/PDE3B/ACE/PTGER2/PLCB3/CALM3/PPP3CA	0.476581043914254
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	10/1181	69/9376	1.15058474149885	FOSB/FOS/JUN/MAOB/CACNA1C/GRIA3/CALM2/ARC/CALM3/PPP3CA	0.476581043914254
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	25/1181	184/9376	1.07867319515517	MYL9/CFL1/CXCL12/TRPC4/WNT5B/WNT4/MAPK3/CFL2/MYL12A/EFNA5/RHOD/CDC42/LIMK2/CDK5/DPYSL2/PIK3R2/NRP1/RRAS/SEMA4B/PLXNA1/MYL12B/EPHB6/PLXNC1/HRAS/PPP3CA	0.409135157195335
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	14/1181	100/9376	1.11146486028789	CD55/CSF3R/ITGA1/CD59/IL1B/CD1D/CD4/HLA-DPA1/THPO/HLA-DOB/HLA-DQB1/CD38/TFRC/FLT3LG	0.425396305769754
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	7/1181	47/9376	1.18240942583818	INSR/IRS2/PKM/CACNA1C/MAPK3/PIK3R2/HK2	0.475898972164645
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	10/1181	70/9376	1.1341478166203	IRS2/NFKBIA/TNFRSF1A/NFKBIB/ADIPOR1/POMC/ACSL1/PPARGC1A/ACSL5/NFKBIE	0.427648755456681
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	13/1181	93/9376	1.10975754099405	EGR1/JUN/CACNA1C/ADCY1/MAPK3/ADCY3/CALM2/CDC42/MAP2K3/MAPK12/PLCB3/CALM3/HRAS	0.40380135845564
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	13/1181	93/9376	1.10975754099405	MYC/LAMA4/GADD45A/NFKBIA/CYCS/FHIT/LAMC1/CKS2/TP53/CDK4/PIK3R2/CKS1B/TRAF4	0.40380135845564
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	16/1181	116/9376	1.0950392712196	ACTB/MYL9/CXCL12/ACTG1/VCAM1/MYL12A/CLDN10/THY1/ACTN1/CDC42/PIK3R2/ICAM1/MYL12B/MAPK12/ACTN4/CLDN23	0.390987350227648
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	3/1181	18/9376	1.32317245272368	FUCA2/NEU1/HEXB	0.520972950129887
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	3/1181	18/9376	1.32317245272368	CD320/PRDX1/MMADHC	0.520972950129887
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	12/1181	87/9376	1.0950392712196	FOS/JUN/MYC/GADD45A/CYCS/MAPK3/TP53/TGFBR2/PIK3R2/ARAF/HRAS/RPS6KB2	0.338076007006604
Organismal Systems	Immune system	hsa04611	Platelet activation	17/1181	126/9376	1.07113960458584	ACTB/RASGRP2/ACTG1/APBB1IP/F2R/ADCY1/MAPK3/MYL12A/ADCY3/MYLK3/P2RY1/PIK3R2/MYL12B/MAPK12/PTGIR/PLCB3/LYN	0.305184140691765
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	10/1181	72/9376	1.10264371060307	NFKBIA/RNF125/ISG15/NFKBIB/CXCL8/PIN1/MAPK12/TANK/TRIM25/AZI2	0.331894342113577
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	11/1181	80/9376	1.09161727349704	RPS6/EIF4EBP1/MAPK3/HGF/SHC1/EIF4E/PIK3R2/KDR/ARAF/HRAS/RPS6KB2	0.31239955544004
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	21/1181	158/9376	1.05518815850116	RPS6/INSR/TNFRSF1A/WNT5B/EIF4EBP1/WNT4/MAPK3/RHEB/EIF4E/LAMTOR1/MLST8/PIK3R2/LAMTOR5/LAMTOR2/AKT1S1/ATP6V1B2/DEPTOR/HRAS/SEH1L/LAMTOR4/RPS6KB2	0.265578065151576
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	7/1181	50/9376	1.11146486028789	IL15/CXCL12/IL15RA/CD40/HLA-DPA1/HLA-DOB/HLA-DQB1	0.29999317932634
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	24/1181	183/9376	1.04118488083175	RAN/NHP2/FBL/IMP4/EMG1/RPP25/SNU13/NOP10/TBL3/AK6/DKC1/NXT1/IMP3/RPP40/NOP58/REXO2/GAR1/RCL1/POP4/UTP4/GNL2/NOB1/RRP7A/UTP15	0.213585043020097
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	31/1181	238/9376	1.03407595044792	PLA2G2A/INSR/IGF2/RASGRP2/FGF7/GNG4/MAPK3/HGF/EFNA5/SHC1/VEGFB/FGF10/CALM2/VEGFC/CDC42/PLCE1/GNB2/PIK3R2/RASAL2/NTRK1/RRAS/KSR1/NGF/KDR/CALM3/MRAS/HRAS/GAB2/GNG10/FLT3LG/GNG12	0.202137545443536
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	13/1181	97/9376	1.06399434342729	FOS/CACNA1C/GNG4/ADCY1/MAPK3/GRIA3/ADCY3/CALM2/GNB2/PLCB3/CALM3/GNG10/GNG12	0.240498834170246
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	2/1181	12/9376	1.32317245272368	COQ2/COQ3	0.425236331556336
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	9/1181	67/9376	1.06643749921013	CACNA1C/ADCY1/MAPK3/CALM2/PLCB3/CALM3/ARAF/HRAS/PPP3CA	0.207174009404306
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	10/1181	75/9376	1.05853796217894	GPX1/ADCY1/HSPA5/ATP1B3/ADCY3/HSP90B1/GPX3/PDIA4/PLCB3/TTF2	0.193214411849001
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	20/1181	154/9376	1.03104346965482	ACTB/MYL9/FOS/JUN/MYL6/ACTG1/NPR1/CACNA1C/ADCY1/MAPK3/ADCY3/CALM2/MYLK3/PLCB3/CALM3/HRAS/CD38/CACNB2/CAMK1/PPP3CA	0.147453187413298
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	6/1181	44/9376	1.08259564313756	POLD4/POLD2/UNG/NEIL2/MUTYH/POLE3	0.208464553779935
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	32/1181	250/9376	1.01619644369179	HLA-C/HLA-B/HSPA1B/HSPA1A/HLA-A/LDLR/PSD/SH3KBP1/HSPA8/CAV1/PSD3/HLA-F/CBLB/CAV2/CDC42/ARPC1B/ARPC2/TGFBR2/ARPC4/CAPZB/MVB12A/RAB7A/HRAS/BIN1/KIF5A/ARPC5/CHMP5/SNF8/VPS37C/TFRC/RAB11FIP3/SNX5	0.0985338711939126
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	10/1181	76/9376	1.04460983109764	ACTB/ACTG1/ADCY1/ATP1B3/ADCY3/CALM2/MYLK3/SLC4A2/PLCB3/CALM3	0.14822860070196
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	10/1181	77/9376	1.03104346965482	GADD45A/MAPK3/TP53/CDK4/CDC42/TGFBR2/PIK3R2/CDKN2A/ARAF/RPS6KB2	0.103832569667097
Organismal Systems	Digestive system	hsa04970	Salivary secretion	12/1181	93/9376	1.0243915763022	CST3/ADCY1/ATP1B3/ADCY3/CALM2/ATP2B3/SLC4A2/PLCB3/CALM3/BST1/LYZ/CD38	0.0897373570553847
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	14/1181	109/9376	1.01969253237421	INSR/IRS2/PTPRF/NFKBIA/TNFRSF1A/PYGL/FOXO1/SLC27A3/GYS1/PIK3R2/SLC27A5/PPARGC1A/GFPT2/RPS6KB2	0.0785021124667831
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	17/1181	133/9376	1.01476383592342	HLA-C/HLA-B/HLA-A/IFNGR2/MAPK3/SHC1/FAS/PIK3R2/IFNAR2/ICAM1/ARAF/IFNGR1/HRAS/MICB/BID/PPP3CA/TNFRSF10B	0.065096053823459
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	14/1181	110/9376	1.01042260026172	HSP90AA1/ADCY1/MAPK3/ADCY3/PIK3R2/CDC25B/ANAPC11/PDE3B/ANAPC15/MAPK12/MAD2L2/CDC26/ARAF/CCNB1	0.0417409552998052
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	17/1181	134/9376	1.00719097147623	PLA2G2A/MYL9/CALD1/MYL6/NPR1/CACNA1C/ADCY1/MAPK3/ADCY3/CALM2/ACTA2/MYLK3/GNA12/PTGIR/PLCB3/CALM3/ARAF	0.0318268085154757
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	11/1181	86/9376	1.01545792883445	JUN/MYC/EIF4EBP1/MAPK3/CBLB/SHC1/PIK3R2/ARAF/HRAS/RPS6KB2/STAT5A	0.0546674454464058
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	32/1181	254/9376	1.00019335009034	EDNRB/SLC8A1/FGF7/HTR2A/F2R/CACNA1C/ADCY1/HGF/PPIF/ADCY3/VDAC1/PTGER3/VEGFB/FGF10/CALM2/PHKG1/VEGFC/MYLK3/PLCE1/ATP2B3/PLCD1/NTRK1/ATP2A2/NGF/KDR/PLCB3/HRH1/CALM3/CD38/SLC25A5/CAMK1/PPP3CA	0.00118591158526371
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	3/1181	23/9376	1.03552626734897	PDSS1/ACAT1/ZMPSTE24	0.0647551238890854
NA	NA	hsa03272	Virion - Hepatitis viruses	6/1181	48/9376	0.99237933954276	LDLR/CD81/HSPG2/CLDN10/SCARB1/CLDN23	-0.0200934758783295
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	2/1181	15/9376	1.05853796217894	NTPCR/NFS1	0.0861307471728312
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	9/1181	73/9376	0.978785102014777	AOX1/MGST1/MAOB/GSTK1/ADH5/GSTP1/GSTT2B/GSTO1/ADH1C	-0.0690759673217939
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	15/1181	122/9376	0.976110825779764	INSR/IRS2/EIF4EBP1/FOXO1/RHEB/ADIPOR1/PFKL/GYS1/PIK3R2/PFKM/TBC1D1/AKT1S1/PPARGC1A/FASN/RPS6KB2	-0.100821327982635
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	15/1181	122/9376	0.976110825779764	FOS/JUN/MAP3K8/NFKBIA/NFKBIB/MAPK3/CBLB/CDK4/CDC42/PIK3R2/CD4/MAPK12/HRAS/NFKBIE/PPP3CA	-0.100821327982635
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	15/1181	122/9376	0.976110825779764	FOS/IRS2/JUNB/CACNA1C/IGFBP3/ADCY1/MAPK3/ADCY3/SHC1/PIK3R2/MAP2K3/MAPK12/PLCB3/HRAS/STAT5A	-0.100821327982635
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	4/1181	32/9376	0.99237933954276	TNFRSF1A/CYCS/BOK/BID	-0.0163922018847754
Human Diseases	Immune disease	hsa05310	Asthma	4/1181	32/9376	0.99237933954276	CD40/HLA-DPA1/HLA-DOB/HLA-DQB1	-0.0163922018847754
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	25/1181	205/9376	0.968174965407571	C3/HLA-C/HLA-B/HLA-A/JUN/PKM/NFKBIA/MAPKAPK2/MAPK3/RANBP1/HLA-F/TP53/SRF/CDK4/ACTN1/CDC42/NFKB2/PIK3R2/EGR3/CDKN2A/GTF2H3/HRAS/LYN/ACTN4/STAT5A	-0.174893462639106
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	5/1181	41/9376	0.968174965407571	MAOB/GCAT/SHMT2/PGAM1/DLD	-0.0775246402621457
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	5/1181	41/9376	0.968174965407571	POLD4/POLD2/SSBP1/RPA3/RPA4	-0.0775246402621457
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	11/1181	91/9376	0.959663537140252	FOS/JUN/NFKBIA/CD81/NFKBIB/MAPK3/PIK3R2/HRAS/LYN/NFKBIE/PPP3CA	-0.146778911286827
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	14/1181	116/9376	0.958159362317148	CACNA1C/SLC38A2/GNG4/ADCY1/MAPK3/GRIA3/HOMER1/ADCY3/GLUL/GNB2/PLCB3/GNG10/PPP3CA/GNG12	-0.17213052930145
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/1181	16/9376	0.99237933954276	MAOB/MIF	-0.0115811260046504
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	19/1181	158/9376	0.954694048167719	MYC/GADD45A/CDC7/CHEK2/TP53/CDK4/SKP1/CDC25B/ANAPC11/E2F4/ANAPC15/MAD2L2/CDKN2A/NDC80/CDC26/DBF4/TFDP1/E2F5/CCNB1	-0.218022622139389
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	7/1181	59/9376	0.941919373125332	MYC/GADD45A/MAPK3/TP53/PIK3R2/ARAF/HRAS	-0.169885127814562
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	9/1181	76/9376	0.940148847987878	DBI/SORBS1/SCP2/FABP5/UBC/SLC27A5/PLTP/ACSL1/ACSL5	-0.198872138604129
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	8/1181	68/9376	0.934004084275539	RDH10/DHRS3/AOX1/ADH5/DHRS4L2/ADH1C/DGAT1/BCO1	-0.207338253698623
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	20/1181	168/9376	0.945123180516915	IL15/MCL1/AOX1/MYC/PIM1/IL15RA/OSMR/IFNGR2/CSF3R/IL13RA1/PIK3R2/IFNAR2/CLCF1/THPO/IL10RB/IFNGR1/HRAS/STAT6/STAT2/STAT5A	-0.272456407857827
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	24/1181	201/9376	0.947944443742338	NFKBIZ/ID2/NUPR1/MYC/GADD45A/MEIS1/IGFBP3/CEBPB/PBX1/GRIA3/FOXO1/MAF/TP53/CXCL8/ETV7/TGFBR2/NTRK1/CD40/RUNX1/BCL6/RARA/ZBTB16/WT1/NR4A3	-0.283203223261267
Organismal Systems	Nervous system	hsa04730	Long-term depression	7/1181	60/9376	0.926220716906576	MAPK3/GRIA3/GNA12/PLCB3/ARAF/HRAS/LYN	-0.217636345251575
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/1181	17/9376	0.934004084275539	GLUL/CA12	-0.103386278898416
Cellular Processes	Cell motility	hsa04814	Motor proteins	23/1181	194/9376	0.941225765339525	ACTB/MYL9/TPM2/TUBB/TUBA1B/MYL6/ACTG1/TUBB4B/TUBA1C/TUBB6/MYL12A/TUBB3/TUBA1A/TUBG1/ACTA2/TUBB2A/CAPZB/DCTN6/DYNLT1/MYL12B/TPM1/KIF5A/TUBE1	-0.314018555428233
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	5/1181	44/9376	0.902163035947964	ADCY3/AQP3/ARHGDIA/DCTN6/ARHGDIB	-0.246932383834388
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	12/1181	104/9376	0.91604246727024	PLA2G2A/LPCAT4/CHKB/LPCAT3/GPD1L/PTDSS2/PLPP4/LYPLA2/CRLS1/GDPD5/CDIPT/PCYT2	-0.326832874552492
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	4/1181	36/9376	0.882114968482454	GALNT13/GALNT15/C1GALT1C1/C1GALT1C1L	-0.269012576659576
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	6/1181	54/9376	0.882114968482454	RPA3/CENPX/RPA4/ERCC1/FANCG/FANCE	-0.329789711377996
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	17/1181	148/9376	0.911916149850104	FOS/JUN/MYC/GADD45A/FGF7/WNT5B/WNT4/MAPK3/SHC1/TP53/CDK4/FGF10/NFKB2/PIK3R2/ARAF/HRAS/RPS6KB2	-0.410024173857607
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	5/1181	46/9376	0.862938556124139	HMBS/CPOX/FXN/EARS2/UROS	-0.353744343944876
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	13/1181	115/9376	0.897456098369105	JUND/FOS/EGR1/ADCY1/MAPK3/AKAP13/ADCY3/NR4A2/MMP17/GNA12/PDE4B/PLCB3/ARAF	-0.420016086191587
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	15/1181	133/9376	0.895379855226551	FOS/MAOB/CACNA1C/GNG4/GRIA3/COMT/CALM2/GNB2/MAPK12/PLCB3/CALM3/KIF5A/GNG10/PPP3CA/GNG12	-0.461286525433765
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	4/1181	38/9376	0.835687864878114	INSR/MAPK3/ATP1B3/PIK3R2	-0.385274806151942
Human Diseases	Substance dependence	hsa05032	Morphine addiction	10/1181	91/9376	0.872421397400229	GABRA2/GABRE/GNG4/ADCY1/ADCY3/GNB2/PDE3B/PDE4B/GNG10/GNG12	-0.464241211684819
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	5/1181	48/9376	0.8269827829523	ATP1B3/PIK3R2/HK2/PLCB3/SLC2A5	-0.45619632271911
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	11/1181	101/9376	0.864647345344187	EDNRB/WNT5B/WNT4/ADCY1/MAPK3/ADCY3/CALM2/POMC/PLCB3/CALM3/HRAS	-0.51916644329745
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	11/1181	102/9376	0.856170410585911	PLA2G2A/ADCY1/ATP1B3/ADCY3/CPB1/ATP2B3/SLC4A2/ATP2A2/PLCB3/BST1/CD38	-0.554435319825876
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	17/1181	155/9376	0.870732839856874	LDLR/NR4A1/CACNA1C/WNT5B/STAR/WNT4/ADCY1/MAPK3/PBX1/ADCY3/CDK4/FH/POMC/KCNK3/CDKN2A/PLCB3/SCARB1	-0.616028995325687
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	8/1181	78/9376	0.81425997090688	TPI1/INPP4B/IMPA2/ALDH6A1/PLCE1/PLCD1/PLCB3/CDIPT	-0.625308234352736
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	7/1181	69/9376	0.805409319049197	MAPK3/PIK3R2/MAP2K3/MAPK12/HRAS/GAB2/LYN	-0.615854096108575
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	3/1181	32/9376	0.74428450465707	GABARAP/MLST8/GABARAPL1	-0.550049441022467
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	16/1181	149/9376	0.852513795043445	INSR/F2R/ADCY1/MAPK3/ADCY3/SHC1/RHEB/CXCL8/PIK3R2/RRAS/GNA12/PLCB3/MRAS/LPAR1/HRAS/GAB2	-0.688890796496032
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	11/1181	106/9376	0.82386209320531	HSP90AA1/NFKBIA/GSTP1/MAPK3/FOXO1/TP53/HSP90B1/PIK3R2/ARAF/HRAS/INSRR	-0.692312231365947
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	12/1181	115/9376	0.828421013879174	FOS/CACNA1C/GNG4/ADCY1/MAPK3/ADCY3/GNB2/PIK3R2/PLCB3/HRAS/GNG10/GNG12	-0.702781277843221
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	12/1181	115/9376	0.828421013879174	DUSP1/MAOB/HTR2A/CACNA1C/GNG4/MAPK3/GNB2/PLCB3/ARAF/HRAS/GNG10/GNG12	-0.702781277843221
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/1181	12/9376	0.66158622636184	NCAM2	-0.44529114544633
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/1181	23/9376	0.690350844899312	B4GALT3/B4GALT1	-0.564409686042588
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/1181	23/9376	0.690350844899312	ATP1B3/SLC25A10	-0.564409686042588
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	9/1181	89/9376	0.802823735360435	THBS2/LAMA4/TNC/LAMC1/HSPG2/ITGA1/THBS1/COL6A2/ITGB5	-0.709492850662155
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	7/1181	71/9376	0.782721732597107	FOS/MAPK3/SHC1/PIK3R2/MAPK12/HRAS/STAT5A	-0.697627164811903
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	4/1181	43/9376	0.738514857334147	PLA2G2A/ACAT1/SCARB1/DGAT1	-0.652389136539381
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	19/1181	178/9376	0.847425053991571	JUN/MYC/DKK1/NKD2/TLE2/WNT5B/WNT4/ROR2/TP53/RUVBL1/SKP1/GPC4/APCDD1/PLCB3/BAMBI/CACYBP/TLE6/RSPO3/PPP3CA	-0.780158117268452
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	10/1181	99/9376	0.801922698620412	FOS/JUN/EIF4EBP1/HIF1A/MAPK3/RHEB/CHKB/PIK3R2/HRAS/RPS6KB2	-0.752115670805537
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	12/1181	117/9376	0.81425997090688	ACTB/ACTG1/RUVBL2/RUVBL1/INO80B/MORF4L2/SMARCD3/ACTL6A/MBD3/SMARCD2/POLE3/DPF3	-0.76745426881887
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	37/1181	333/9376	0.882114968482454	HLA-C/HLA-B/HLA-A/THBS2/LAMA4/PKM/TNC/TNFRSF1A/WNT5B/EIF4EBP1/ISG15/WNT4/LAMC1/MAPK3/ITGA1/FOXO1/HLA-F/TP53/CDK4/TUBG1/RHEB/THBS1/CDC42/FAS/MAGI1/COL6A2/ITGB5/PIK3R2/IFNAR2/TICAM1/ATP6V1B2/HRAS/MX2/RPS6KB2/BCAP31/STAT2/TLR3	-0.831496878771585
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	3/1181	34/9376	0.700503063206654	RORA/SKP1/BHLHE40	-0.664122233727955
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	15/1181	144/9376	0.8269827829523	ID2/MYC/ID4/ID1/WNT5B/MEIS1/PCGF5/WNT4/MAPK3/KLF4/ID3/PIK3R2/MAPK12/BMP4/HRAS	-0.79425284361574
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	4/1181	44/9376	0.721730428758371	TAF10/TAF4B/TAF9/GTF2H3	-0.702329321448711
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/1181	24/9376	0.66158622636184	B3GAT3/B3GALT6	-0.630140670312489
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/1181	13/9376	0.61069497818016	XRCC6	-0.533200169042174
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	7/1181	73/9376	0.761277301567049	RAN/PPIA/MAP1A/ELL2/PIN1/CD4/MX2	-0.777284025943048
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	4/1181	45/9376	0.705691974785963	ABCC3/TAP2/TAP1/DEFB1	-0.751242890231026
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	5/1181	55/9376	0.721730428758371	ACER3/UGCG/PSAP/NEU1/HEXB	-0.785691251995894
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	24/1181	226/9376	0.843083332708894	MYL9/FOS/JUN/NFKBIA/NPR1/F2R/CACNA1C/ADCY1/MAPK3/GRIA3/ATP1B3/ADCY3/PTGER3/CALM2/PLCE1/ATP2B3/PIK3R2/POMC/RRAS/PDE3B/ATP2A2/PTGER2/PDE4B/CALM3	-0.906460442185838
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	6/1181	65/9376	0.732833973816192	ABHD16A/PNPLA2/PLPP4/ALDH9A1/ALDH2/DGAT1	-0.820494839453008
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	6/1181	65/9376	0.732833973816192	TRPC4/CACNA1C/MAPK3/PIK3R2/PLCB3/HRAS	-0.820494839453008
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/1181	36/9376	0.66158622636184	SORD/DCXR/FGGY	-0.772257173379485
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	10/1181	103/9376	0.770780069547775	PABPC1/EIF4A3/DAZAP1/PABPC4/ALYREF/NXT1/MAGOH/NCBP2/GLE1/MAGOHB	-0.887967287845354
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/1181	26/9376	0.61069497818016	SLC5A6/SCARB1	-0.754582940509709
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	15/1181	150/9376	0.793903471634208	MYC/GADD45A/FGF7/WNT5B/WNT4/MAPK3/HGF/SHC1/TP53/FGF10/TGFBR2/PIK3R2/ARAF/HRAS/RPS6KB2	-0.965930075765323
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	12/1181	125/9376	0.76214733276884	SPTSSA/MAP3K5/TNFRSF1A/MAPK3/TP53/PIK3R2/GNA12/MAPK12/PLCB3/HRAS/GAB2/BID	-1.01625992481621
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	4/1181	49/9376	0.64808446664017	FOSB/JUN/MAOB/CDK5	-0.937565453409459
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	9/1181	98/9376	0.729095024970191	INPP4B/IMPA2/CALM2/PLCE1/PIK3R2/PLCD1/PLCB3/CALM3/CDIPT	-1.02338475348006
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/1181	16/9376	0.49618966977138	HEXB	-0.765641108085227
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/1181	28/9376	0.567073908310149	B4GALT3/B4GALT1	-0.870902490763665
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7/1181	79/9376	0.703458772334109	MGST1/GSTK1/ADH5/GSTP1/GSTT2B/GSTO1/ADH1C	-1.00476227224604
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	15/1181	154/9376	0.773282602241112	TPM2/SLC8A1/CACNA1C/ADCY1/MAPK3/ATP1B3/ADCY3/CALM2/ATP2B3/MAPK12/ATP2A2/TPM1/PLCB3/CALM3/CACNB2	-1.07688358657455
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	22/1181	217/9376	0.804879095666018	FOS/MGST1/JUN/HSP90AA1/MYC/FGF7/CACNA1C/EIF4EBP1/ADCY1/MAPK3/KLF4/ADCY3/GSTT2B/HSP90B1/FGF10/PIK3R2/BCL6/GSTO1/PAQR7/HRAS/RPS6KB2/STAT5A	-1.10394070113309
Organismal Systems	Digestive system	hsa04976	Bile secretion	8/1181	90/9376	0.705691974785963	LDLR/ABCC3/ADCY1/ATP1B3/ADCY3/SLC27A5/SLC4A2/SCARB1	-1.06498901388877
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/1181	29/9376	0.547519635609799	CALM2/CALM3	-0.926400377135546
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/1181	17/9376	0.46700204213777	GGT5	-0.8349709965977
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/1181	17/9376	0.46700204213777	TFRC	-0.8349709965977
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	13/1181	138/9376	0.747880081974254	ADCY1/MAPK3/ADCY3/CALM2/SKP1/ANAPC11/ANAPC15/MAPK12/MAD2L2/CALM3/CDC26/PPP3CA/CCNB1	-1.13264504534648
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	3/1181	41/9376	0.580904979244543	GABRA2/GABRE/GRIA3	-1.02090040547678
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	5/1181	62/9376	0.640244735188878	TLE2/DTX4/DTX3L/NCSTN/TLE6	-1.07887466386496
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	7/1181	83/9376	0.669557144751742	PCGF5/UBE2D3/SKP1/SFMBT2/CBX3/TFDP1/AUTS2	-1.14787223651538
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	5/1181	63/9376	0.63008212034461	PLA2G2A/GGT5/GPX4/PTGES2/PTGES	-1.11832209218653
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	5/1181	63/9376	0.63008212034461	GADD45A/WNT5B/WNT4/TP53/BMP4	-1.11832209218653
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4/1181	53/9376	0.599172431422044	SLC8A1/ATP1B3/ATP2B3/PLCB3	-1.11084581967479
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	2/1181	31/9376	0.512195788151102	ALDH9A1/ALDH2	-1.0326968396026
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	2/1181	33/9376	0.481153619172247	VAMP5/STX8	-1.13341431967493
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	5/1181	70/9376	0.567073908310149	MGST1/GSTK1/GSTP1/GSTT2B/GSTO1	-1.38012163731241
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	8/1181	103/9376	0.61662405563822	SLC8A1/SLC38A2/ATP1B3/SLC1A5/COL15A1/COL6A2/CPB1/SLC7A7	-1.48514702394535
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	12/1181	143/9376	0.666212703469266	C3/C1R/C1S/C2/SNRPB/SNRPD1/ACTN1/CD40/HLA-DPA1/HLA-DOB/HLA-DQB1/ACTN4	-1.52687158520343
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/1181	51/9376	0.46700204213777	PLA2G2A/ENPP2/LPCAT4	-1.44884631629968
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/1181	26/9376	0.30534748909008	PLA2G2A	-1.34643250134449
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	4/1181	66/9376	0.481153619172247	COMT/SRD5A3/HSD17B7/STS	-1.6057281721012
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/1181	28/9376	0.283536954155074	ATP6V1B2	-1.44128400469214
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/1181	29/9376	0.273759817804899	TEAD4	-1.48689143579354
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/1181	30/9376	0.264634490544736	PLA2G2A	-1.53139457246924
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	12/1181	157/9376	0.606805201249076	ACTB/ID2/MYC/NKD2/ID1/ACTG1/SERPINE1/WNT5B/WNT4/TEAD4/TGFBR2/BMP4	-1.88604387301445
NA	NA	hsa04081	Hormone signaling	18/1181	219/9376	0.652523401343185	INSR/IRS2/IGF2/NPR1/GNG4/ADCY1/ADCY3/ADIPOR1/GNB2/PIK3R2/POMC/THPO/GNA12/PLCB3/GNG10/ADRA2A/STAT5A/GNG12	-1.97518200402477
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	5/1181	86/9376	0.461571785833842	CACNA1C/ADCY1/ATP1B3/ADCY3/PLCB3	-1.90416810298226
NA	NA	hsa04082	Neuroactive ligand signaling	15/1181	199/9376	0.59841970223684	GABRA2/HTR2A/GABRE/GNG4/ADCY1/GRIA3/ADCY3/P2RY1/GNB2/POMC/PLCB3/HRH1/GNG10/ADRA2A/GNG12	-2.17362528691616
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	14/1181	195/9376	0.569981979634816	C3/ACTB/ACTG1/MAPK3/PPIF/CASP4/GSDMD/VDAC1/CASP1/PIK3R2/TLR4/MAPK12/PLCB3/SLC25A5	-2.30353638038092
Organismal Systems	Sensory system	hsa04742	Taste transduction	4/1181	86/9376	0.369257428667074	GABRA2/CACNA1C/P2RY1/PLCB3	-2.23064069438704
NA	NA	hsa04382	Cornified envelope formation	15/1181	217/9376	0.548781201590467	S100A6/S100A4/S100A11/S100A16/S100A3/CLDN10/UGCG/KAZN/ELOVL1/ABHD5/S100A1/PKP2/PLEC/KRT23/CLDN23	-2.55287252988554
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	3/1181	79/9376	0.301482331000332	SYT1/ATP6V1B2/STXBP1	-2.36676770320406
Human Diseases	Substance dependence	hsa05034	Alcoholism	12/1181	191/9376	0.498787521445576	FOSB/MAOB/GNG4/MAPK3/SHC1/CALM2/GNB2/CALM3/ARAF/HRAS/GNG10/GNG12	-2.65665455250349
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	1/1181	56/9376	0.141768477077537	GAS1	-2.44526891801825
NA	NA	hsa04519	Cadherin signaling	30/1181	404/9376	0.589532280916491	ACTB/GABRA2/GJA1/ACTG1/NFKBIA/GABRE/WNT5B/DES/WNT4/MAPK3/CDH3/TEAD4/ACTN1/CDC42/ARPC1B/CDH13/ARPC2/ARPC4/RRAS/PKP2/MAP2K3/MAPK12/KDR/MRAS/NCSTN/KRT23/HRAS/ARPC5/AMOTL2/ACTN4	-3.2015564681978
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	19/1181	323/9376	0.46700204213777	MCL1/MYC/IRS2/PIM1/TNC/TIMP3/MAPK3/EFNA5/SHC1/TP53/THBS1/SLC7A1/PIK3R2/CDC25B/CDKN2A/TPM1/FOXP1/HRAS/CCNG1	-3.70055321697959
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	20/1181	370/9376	0.429137011694167	C3/TSPO/GABRA2/GAL/EDNRB/HTR2A/F2R/GABRE/NPW/GRIA3/PTGER3/F2RL2/P2RY1/POMC/PTGIR/PTGER2/HRH1/LPAR1/ADRA2A/TMEM97	-4.25307347333382
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	4/1181	449/9376	0.0707263671834484	SLC8A1/ADCY3/CALM2/CALM3	-7.66037668570403