category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	67/780	238/9376	3.38392587804352	C3/RPL29/C1R/C1S/RPL13/CFD/RPL35/RPL4/RPL39/RPLP0/RPL36A/FOS/RPL12/RPL37A/RPL8/RPS19/RPS15/RPS6/JUN/RPLP2/RPL34/RPS3A/RPL22L1/RPL36/RPL28/RPS24/RPS3/RPS9/RPS7/C2/RPS17/RPSA/RPL6/RPS18/RPLP1/RPL36AL/RPL18/MASP1/TNFRSF1A/RPS4X/RPL32/RPL19/RPS15A/MYD88/RPL9/RPL18A/RPL7/FAU/RPS2/ISG15/RPS23/RPS21/MAPK3/RPL26/RPL23/RPL37/RPS25/IL6ST/RPL11/RPS5/RPL7A/IL1B/NFKBIB/CXCL8/CASP1/RPS12/PIK3R2	11.2212279767514
Genetic Information Processing	Translation	hsa03010	Ribosome	61/780	222/9376	3.3029337029337	RPL29/RPL13/RPL35/RPL4/RPL39/RPLP0/RPL36A/RPL12/RPL37A/RPL8/RPS19/RPS15/RPS6/RPLP2/RPL34/RPS3A/RPL22L1/RPL36/RPL28/RPS24/RPS3/RPS9/RPS7/RPS17/RPSA/RPL6/RPS18/RPLP1/RPL36AL/RPL18/RPS4X/RPL32/RPL19/RPS15A/RPL9/RPL18A/RPL7/FAU/RPS2/RPS23/RPS21/MRPL12/MRPS24/MRPL18/RPL26/RPL23/RPL37/MRPL24/RPS25/RPL11/RPS5/MRPL16/MRPL41/RPL7A/MRPL15/RPS12/MRPL50/MRPL14/MRPL4/MRPS27/MRPL54	10.4601329603511
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	56/780	268/9376	2.51174894756984	MT-ND4/MAOB/MT-ND3/MT-CO2/MAP3K5/TUBB/NDUFS5/DUSP1/TXN/SLC25A6/MT-ATP6/PSMB3/SLC39A6/UBB/TUBA1B/UBE2L6/SLC39A14/TUBA1C/TUBB6/NDUFA13/TUBB4B/COX6A1/CALM2/NDUFC1/NDUFA3/PSMA4/NDUFS7/UQCRQ/NDUFA7/NDUFS8/TRAP1/NFE2L2/TP53/COX6C/CYCS/TUBA1A/UQCRC1/SDHD/COX5B/PSMC3/NDUFA11/NDUFB8/SEM1/TUBB3/NDUFV1/PSMB2/PSMB7/UBC/PSMA2/NDUFA9/CALM3/PSMA3/UBA1/PSMB4/COX7A2L/HSPA5	7.56345621523372
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	52/780	275/9376	2.2729696969697	MT-ND4/EGR1/MT-ND3/MT-CO2/HSPA1B/TUBB/HSPA1A/NDUFS5/SLC25A6/MT-ATP6/LAMC1/PSMB3/CACNA1C/TUBA1B/NCAM2/TUBA1C/TUBB6/NDUFA13/MAPK3/TUBB4B/COX6A1/NDUFC1/NDUFA3/PSMA4/NDUFS7/UQCRQ/NDUFA7/NDUFS8/COX6C/CYCS/IL1B/TUBA1A/UQCRC1/SDHD/COX5B/PSMC3/NDUFA11/NDUFB8/SEM1/PIK3R2/TUBB3/NDUFV1/PSMB2/PSMB7/CAV1/PSMA2/NDUFA9/PSMA3/PRNP/PSMB4/COX7A2L/HSPA5	6.45393506123612
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	64/780	388/9376	1.9827650013217	INSR/MT-ND4/MT-ND3/MT-CO2/MAP3K5/TUBB/NDUFS5/SLC25A6/MT-ATP6/IRS2/PSMB3/TNFRSF1A/CACNA1C/SLC39A6/TUBA1B/WNT5B/SLC39A14/TUBA1C/TUBB6/NDUFA13/DKK1/MAPK3/TUBB4B/COX6A1/CALM2/NDUFC1/NDUFA3/PSMA4/NDUFS7/UQCRQ/NDUFA7/NDUFS8/LRP5/MAP2K2/NCSTN/COX6C/CYCS/IL1B/TUBA1A/UQCRC1/SDHD/GAPDH/COX5B/PSMC3/NDUFA11/NDUFB8/SEM1/PIK3R2/CSNK1E/PLCB3/TUBB3/NDUFV1/IRS1/PSMB2/LRP1/PSMB7/HSD17B10/PSMA2/NDUFA9/CDK5/CALM3/PSMA3/PSMB4/COX7A2L	5.95550712897686
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	31/780	142/9376	2.62419646081618	ACTB/ASS1/FOS/MAP3K5/JUN/MMP2/ACTG1/DUSP1/TXN/VCAM1/SDC2/MGST1/TNFRSF1A/CTSL/HSP90AA1/GSTT2B/CALM2/HSP90B1/GSTP1/NFE2L2/TP53/IL1B/PLAT/PIK3R2/BCL2/SUMO3/KDR/CAV1/CALM3/KLF2/GSTO1	5.87452197920893
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	59/780	368/9376	1.92720178372352	ACTB/MT-ND4/MT-ND3/MT-CO2/MAP3K5/TUBB/NDUFS5/GPX1/ACTG1/MT-ATP6/PFN1/PSMB3/TNFRSF1A/TUBA1B/HNRNPA1/TUBA1C/TUBB6/GPX3/NDUFA13/TUBB4B/COX6A1/NDUFC1/NDUFA3/PSMA4/NDUFS7/UQCRQ/NDUFA7/NDUFS8/SIGMAR1/TP53/COX6C/CYCS/NUP35/TUBA1A/UQCRC1/CASP1/SDHD/COX5B/PSMC3/NDUFA11/NDUFB8/SEM1/TUBB3/TANK/BCL2/NDUFV1/CHCHD10/PSMB2/PSMB7/SRSF3/PSMA2/NDUFA9/UBQLN4/PSMA3/ALYREF/PSMB4/ANG/COX7A2L/HSPA5	5.46598851914161
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	51/780	308/9376	1.99040959040959	TGM2/MT-ND4/MT-ND3/MT-CO2/SOD2/MAP3K5/TUBB/NDUFS5/GPX1/SLC25A6/MT-ATP6/PSMB3/TUBA1B/TUBA1C/TUBB6/GRIA3/GPX3/NDUFA13/TUBB4B/COX6A1/NDUFC1/NDUFA3/PSMA4/NDUFS7/UQCRQ/NDUFA7/NDUFS8/POLR2L/TP53/COX6C/CYCS/TUBA1A/UQCRC1/SDHD/COX5B/PSMC3/NDUFA11/NDUFB8/SEM1/PLCB3/TUBB3/NDUFV1/PSMB2/PSMB7/POLR2E/POLR2K/PSMA2/NDUFA9/PSMA3/PSMB4/COX7A2L	5.32376866546739
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	32/780	157/9376	2.45004082965866	INSR/FOS/MT-CO2/MAP3K5/JUN/NDUFS5/IRS2/TNFRSF1A/NDUFA13/COX6A1/NDUFC1/NDUFA3/NDUFS7/UQCRQ/NDUFA7/NDUFS8/COX6C/CYCS/IL1B/UQCRC1/CXCL8/SDHD/COX5B/NDUFA11/NDUFB8/PIK3R2/ADIPOR1/NDUFV1/IRS1/RXRA/NDUFA9/COX7A2L	5.51915874869494
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	21/780	82/9376	3.07842401500938	HLA-C/HLA-A/B2M/HSPA1B/HSPA1A/HLA-B/CTSB/PSME2/PSME1/CALR/CTSL/HSP90AA1/HLA-F/TAP2/TAPBP/CTSS/PSME3/NFYC/TAP1/LGMN/HSPA5	5.69409200306802
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	15/780	46/9376	3.91973244147157	PSME2/PSME1/PSMB3/PSMB8/PSMB9/PSMA4/PSMC3/SEM1/PSME3/PSMB2/PSMB7/PSMA2/PSMA3/PSMB4/POMP	5.97951397844876
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	68/780	480/9376	1.70290598290598	MT-ND4/MT-ND3/MT-CO2/MAP3K5/TUBB/NDUFS5/GPX1/SLC25A6/MT-ATP6/PSMB3/TNFRSF1A/CACNA1C/UBB/TUBA1B/UBE2L6/WNT5B/TUBA1C/TUBB6/GRIA3/GPX3/NDUFA13/DKK1/MAPK3/TUBB4B/COX6A1/CALM2/NDUFC1/NDUFA3/PSMA4/NDUFS7/UQCRQ/NDUFA7/NDUFS8/LRP5/SIGMAR1/TRAP1/MAP2K2/COX6C/CYCS/IL1B/TUBA1A/UQCRC1/SDHD/COX5B/PSMC3/NDUFA11/NDUFB8/SEM1/CSNK1E/PLCB3/TUBB3/TANK/BCL2/NDUFV1/PSMB2/PSMB7/UBC/HSD17B10/PSMA2/NDUFA9/CDK5/CALM3/PSMA3/PRNP/UBA1/PSMB4/COX7A2L/HSPA5	4.76217343010337
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	41/780	248/9376	1.98726220016543	ACTB/MYL9/FOS/TUBB/JUN/RPS3/FLNA/ACTG1/TXN/PFN1/TNFRSF1A/HSP90AA1/TUBA1B/MYD88/TUBA1C/AHNAK2/TUBB6/PKN1/MAPK3/TUBB4B/GSDMD/HSP90B1/ARPC4/MAP2K2/MYC/CASP4/CYCS/IL1B/TUBA1A/CXCL8/MYL12B/CASP1/ARPC1A/RRAS/GAPDH/NOD1/TUBB3/BCL2/RAB7A/ELMO1/M6PR	4.74630092735673
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	27/780	137/9376	2.36900617630545	ACTB/FOS/CTSC/GADD45A/MAP3K5/JUN/ACTG1/CTSB/MCL1/CTSK/TNFRSF1A/CTSL/TUBA1B/TUBA1C/MAPK3/TP53/MAP2K2/NTRK1/CYCS/ENDOG/TUBA1A/CTSS/CTSO/PIK3R2/BCL2/LMNB2/CTSD	4.8622573738942
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	29/780	155/9376	2.24899917287014	C3/C1R/ACTB/HLA-C/HLA-A/THBS2/COLEC11/TUBB/HLA-B/ACTG1/CALR/CTSL/TUBA1B/THBS1/TUBA1C/TUBB6/TUBB4B/TCIRG1/ITGB5/HLA-F/TAP2/TUBA1A/CTSS/TUBB3/THBS3/TAP1/RAB7A/LAMP1/M6PR	4.72306285205026
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	37/780	227/9376	1.95929063594262	FOS/MT-ND4/MT-ND3/MT-CO2/SOD2/MAP3K5/JUN/NDUFS5/SLC25A6/MT-ATP6/MGST1/HIF1A/GSTT2B/NDUFA13/MAPK3/HGF/COX6A1/NDUFC1/NDUFA3/NDUFS7/UQCRQ/NDUFA7/NDUFS8/NFE2L2/MAP2K2/COX6C/UQCRC1/EPHX1/SDHD/COX5B/NDUFA11/NDUFB8/PIK3R2/NDUFV1/NDUFA9/COX7A2L/GSTO1	4.4071827152358
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	26/780	138/9376	2.26473429951691	MT-ND4/MT-ND3/MT-CO2/NDUFS5/MT-ATP6/NDUFA13/TCIRG1/COX6A1/NDUFC1/NDUFA3/NDUFS7/UQCRQ/NDUFA7/NDUFS8/COX6C/CYCS/UQCRC1/SDHD/COX5B/NDUFA11/NDUFB8/PPA2/NDUFV1/PPA1/NDUFA9/COX7A2L	4.50852619318003
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	34/780	203/9376	2.01328786156372	ACTB/COL6A2/MYL9/THBS2/ZYX/JUN/LAMA4/TNC/FLNA/ACTG1/LAMC1/ACTN1/THBS1/TNXB/ITGA1/MAPK3/HGF/ITGB5/COL6A1/VEGFB/SHC1/PARVA/FLNB/MYL12B/PIK3R2/VEGFC/THBS3/BCL2/KDR/CAV1/COL1A1/ACTN4/PARVB/MYLK3	4.3965285579779
NA	NA	hsa04518	Integrin signaling	28/780	154/9376	2.18554778554779	C3/ACTB/COL6A2/THBS2/LAMA4/TNC/FLNA/ACTG1/LAMC1/VCAM1/ACTN1/THBS1/TNXB/ITGA1/HGF/ITGB5/COL6A1/VEGFB/PARVA/FLNB/PIK3R2/VEGFC/THBS3/LIMS1/KDR/COL1A1/ACTN4/PARVB	4.46839545362363
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	19/780	88/9376	2.595337995338	C3/SERPING1/C1R/C1S/CFD/F2R/C2/CD55/MASP1/PROS1/CD59/SERPINE1/F2RL2/CFI/A2M/CLU/PLAT/PROCR/PLAU	4.5291601502919
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	36/780	227/9376	1.9063368349712	HLA-C/CXCL12/HLA-A/B2M/HLA-B/CALR/GNG4/TNFRSF1A/PTGER3/EIF4EBP1/MAPK3/CDK4/ADCY3/ADCY1/CALM2/HLA-F/CCL4/TP53/MAP2K2/AKAP13/MYC/CYCS/TAP2/IL1B/CXCL8/CCL4L2/TAPBP/GNB2/RHEB/GNAO1/PIK3R2/PLCB3/TAP1/CALM3/GNG12/IL10RB	4.16390182871076
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	13/780	50/9376	3.12533333333333	THBS2/CD81/VCAM1/SDC2/MYD88/THBS1/HGF/GYPC/IL1B/CXCL8/THBS3/LRP1/CD40	4.53888402892104
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	33/780	205/9376	1.93500938086304	INSR/MT-ND4/MT-ND3/MT-CO2/MMP2/NDUFS5/SLC25A6/MT-ATP6/NDUFA13/COX6A1/NDUFC1/NDUFA3/NDUFS7/UQCRQ/NDUFA7/NDUFS8/COX6C/UQCRC1/SDHD/GAPDH/COX5B/NDUFA11/NDUFB8/PIK3R2/PLCB3/G6PD/NDUFV1/IRS1/COL1A1/NDUFA9/CTSD/GSR/COX7A2L	4.07726827582312
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	36/780	233/9376	1.8572466160449	ACTB/FBLN1/COL6A2/MYL9/TPM2/THBS2/FBLN2/ZYX/DCN/VIM/LMOD1/SDC3/HSPG2/ACTG1/NID2/PLEC/SDC2/ENO1/DES/THBS1/SGCE/ITGA1/ITGB5/PKP2/SNTB1/COL6A1/PDLIM7/BGN/PDLIM2/CAPZB/THBS3/LMNB2/CSRP1/COL1A1/SYNPO2/DIAPH2	3.99138955223571
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	49/780	362/9376	1.62708598951693	IGF2/COL6A2/INSR/THBS2/RPS6/LAMA4/TNC/OSMR/F2R/MCL1/LAMC1/GNG4/CSF3R/NR4A1/FGF7/HSP90AA1/THBS1/EIF4EBP1/TNXB/PKN1/NGFR/ITGA1/MAPK3/CDK4/HGF/ITGB5/HSP90B1/COL6A1/VEGFB/TP53/MAP2K2/NTRK1/MYC/KITLG/GNB2/RHEB/PIK3R2/VEGFC/THBS3/BCL2/IRS1/TEK/NRTN/KDR/RXRA/COL1A1/PPP2R3B/GNG12/PPP2R1A	3.6652815632301
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	28/780	174/9376	1.93433539640436	HSPA1B/MAP3K5/HSPA1A/CALR/HSP90AA1/PRKCSH/DDOST/SSR4/TXNDC5/PDIA4/RPN1/GANAB/HSP90B1/ERO1A/NFE2L2/P4HB/MAN1C1/RAD23A/BCAP31/DNAJB1/LMAN2/UBXN6/DNAJB11/HSPH1/BCL2/UBQLN4/HSPBP1/HSPA5	3.74732230231421
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	21/780	116/9376	2.17612732095491	ALDOA/PKM/ENO1/PC/H6PD/SHMT2/ADH5/GPI/TPI1/RPIA/ALDH6A1/SDHD/GAPDH/PRPS2/HK2/G6PD/PRPS1/ECHS1/FH/PGAM1/MDH2	3.8393930639607
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	25/780	149/9376	2.01686456720014	GABRA2/MT-ND4/MT-ND3/NDUFS5/GNG4/CACNA1C/GABRE/GRIA3/NDUFA13/MAPK3/ADCY3/ADCY1/NDUFC1/NDUFA3/NDUFS7/NDUFA7/NDUFS8/GNB2/NDUFA11/NDUFB8/GNAO1/PLCB3/NDUFV1/NDUFA9/GNG12	3.76886624263248
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	13/780	56/9376	2.79047619047619	C3/EEF1A1/HSPA1B/HSPA1A/MYD88/CXCL2/CYCS/IL1B/CXCL8/CASP1/EEF1G/HSF1/RAB1B	4.04798918616677
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	16/780	78/9376	2.46574621959237	C3/SERPING1/C1R/C1S/FOS/JUN/C2/CFL1/MYD88/MAPK3/CALM2/IL1B/CXCL8/CASP1/NOD1/CALM3	3.91557952886814
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	28/780	180/9376	1.86985754985755	C3/HLA-C/HLA-A/B2M/PILRA/HLA-B/CALR/IFNGR2/TNFRSF1A/MYD88/EIF4EBP1/TNFRSF14/POU2F3/TNFSF14/HLA-F/TP53/CYCS/TAP2/IL1B/TAPBP/RHEB/PIK3R2/BCL2/TAP1/SRSF3/NECTIN2/ALYREF/SRSF1	3.54952013938981
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	15/780	75/9376	2.40410256410256	ASS1/ALDOA/PKM/ENO1/PC/SHMT2/BCAT2/TPI1/RPIA/GAPDH/PRPS2/PYCR2/GLUL/PRPS1/PGAM1	3.67747202839411
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	30/780	204/9376	1.76772247360483	ACTB/IGF2/DCN/RPS6/LUM/MMP2/HSPG2/FLNA/ACTG1/SDC2/CTSL/TIMP3/HIF1A/TWIST2/WNT5B/THBS1/TWIST1/MAPK3/HGF/ITGB5/TP53/MAP2K2/MYC/RRAS/PIK3R2/HPSE/KDR/CAV1/COL1A1/PLAU	3.33942774233126
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	29/780	196/9376	1.77854526425955	C3/HLA-C/HLA-A/FOS/JUN/ZFP36/HLA-B/MAPKAPK2/GNG4/TNFRSF1A/UBB/HIF1A/CLEC2B/MAPK3/CDK4/CXCL2/CALM2/IL6ST/HLA-F/TP53/MAP2K2/MYC/CYCS/CXCL8/GNB2/PIK3R2/UBC/CALM3/GNG12	3.31799172470806
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	19/780	110/9376	2.0762703962704	INSR/RPS6/TIMP1/ALDOA/EPAS1/LDHA/IFNGR2/ENO1/HIF1A/SERPINE1/EIF4EBP1/MAPK3/MAP2K2/ELOB/GAPDH/HK2/PIK3R2/BCL2/TEK	3.42023798224916
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	31/780	216/9376	1.72516619183286	FOS/SOD2/HSPA1B/MAP3K5/JUN/LDLR/HSPA1A/VCAM1/TNFRSF1A/HSP90AA1/MYD88/MAPK3/CXCL2/CALM2/POU2F3/HSP90B1/ERO1A/NFE2L2/TP53/CYCS/IL1B/CXCL8/CASP1/PIK3R2/PLCB3/TANK/BCL2/CD40/RXRA/CALM3/HSPA5	3.24789083267686
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	30/780	212/9376	1.70101596516691	ACTB/INSR/SIPA1L2/ACTG1/F2R/ID1/RASGRP2/PFN1/FGF7/APBB1IP/THBS1/NGFR/MAPK3/ADCY3/ADCY1/HGF/CALM2/DOCK4/VEGFB/P2RY1/MAP2K2/KITLG/RRAS/GNAO1/PIK3R2/PLCB3/VEGFC/TEK/KDR/CALM3	3.10983992737213
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	12/780	59/9376	2.44485006518905	GGT5/GPX1/MGST1/SRM/GSTT2B/GPX3/GSTK1/GGCT/GSTP1/G6PD/GSR/GSTO1	3.35347811216563
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	39/780	300/9376	1.56266666666667	JUND/IGF2/INSR/FOS/HSPA1B/GADD45A/MAP3K5/JUN/HSPA1A/FLNA/DUSP1/MAPKAPK2/RASGRP2/HSPB1/NR4A1/TNFRSF1A/CACNA1C/MAP3K8/FGF7/MYD88/NGFR/MAPK3/HGF/ECSIT/RPS6KA4/VEGFB/TP53/MAP2K2/NTRK1/MYC/KITLG/IL1B/SRF/RRAS/VEGFC/TEK/NRTN/KDR/GNG12	2.98365983122282
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	34/780	253/9376	1.6154048849701	C3/ACTB/MYL9/JUN/ACTG1/PFN1/TNFRSF1A/UBB/ACTN1/MYD88/MAPK3/ARPC4/TP53/PLCD1/CASP4/CYCS/UBE2N/IL1B/NFKBIB/AKT1S1/CXCL8/MYL12B/CASP1/ARPC1A/CAPNS1/NOD1/HK2/PIK3R2/PLCB3/BCL2/WASF1/UBC/ELMO1/ACTN4	2.98907697079404
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	32/780	235/9376	1.63683578832515	ACTB/MT-ND4/MT-ND3/MT-CO2/MAP3K5/RPS6/NDUFS5/ACTG1/NPR1/MT-ATP6/NDUFA13/ADCY3/ADCY1/COX6A1/NDUFC1/NDUFA3/NDUFS7/UQCRQ/NDUFA7/NDUFS8/PNPLA2/COX6C/UQCRC1/AKT1S1/SDHD/COX5B/RHEB/NDUFA11/NDUFB8/NDUFV1/NDUFA9/COX7A2L	2.97816855835355
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	17/780	101/9376	2.02325463315562	EGR1/JUN/MMP2/PIM1/VCAM1/SERPINE1/MAPK3/CDK4/VEGFB/PLCD1/IL1B/CXCL8/PIK3R2/PLCB3/VEGFC/BCL2/COL1A1	3.11438417269402
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	18/780	110/9376	1.96699300699301	ID2/DCN/ID1/ID4/FST/CHRD/NBL1/THBS1/MAPK3/ID3/BAMBI/MYC/LRRC32/TGIF1/SMAD6/FMOD/PPP2R1A/RGMB	3.07296960182847
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	28/780	200/9376	1.6828717948718	ACTB/FOS/TUBB/JUN/RPS3/ACTG1/F2R/TNFRSF1A/TUBA1B/MYD88/TUBA1C/TUBB6/MAPK3/TUBB4B/ARPC4/CLDN10/ABCF2/CASP4/CYCS/IL1B/TUBA1A/NFKBIB/CXCL8/CASP1/ARPC1A/GAPDH/TUBB3/WASF1	2.94043921894808
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	13/780	71/9376	2.20093896713615	LDHA/PKM/HIF1A/SLC1A5/MAPK3/TP53/MAP2K2/NTRK1/MYC/HK2/PIK3R2/G6PD/PGAM1	3.05968458482743
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	23/780	157/9376	1.76096684631716	HLA-C/IGFBP3/HLA-A/GADD45A/HLA-B/SLC25A6/MAPKAPK2/SERPINE1/EIF4EBP1/MAPK3/CDK4/CALM2/HLA-F/CHEK2/TP53/MAP2K2/MYC/CXCL8/RRAS/RHEB/PIK3R2/ZFP36L1/CALM3	2.89639901264492
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	9/780	41/9376	2.63864915572233	MMP2/THBS1/MAPK3/CDK4/TP53/MAP2K2/MYC/TYMP/CXCL8	3.16741874014951
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	30/780	224/9376	1.60989010989011	HLA-C/HLA-A/B2M/FOS/TSPO/EGR1/JUN/IL15/ZFP36/HLA-B/IL15RA/SLC25A6/CALR/TNFRSF1A/MAPK3/CDK4/ADCY3/ADCY1/HLA-F/RAN/CHEK2/TP53/MAP2K2/MYC/RANBP1/SRF/CRTC1/PIK3R2/CD40/VAC14	2.78293030673087
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	7/780	28/9376	3.00512820512821	PPT1/ELOVL3/ACOT7/TECR/HACD1/ACOT2/ECHS1	3.20071161592592
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	13/780	75/9376	2.08355555555556	IGFBP3/GADD45A/RPRM/STEAP3/SERPINE1/THBS1/EI24/CDK4/CHEK2/TP53/CYCS/SHISA5/BCL2	2.83793032549118
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	32/780	250/9376	1.53862564102564	CTSC/PSAP/CTSB/NPC2/CTSK/CTSL/BLOC1S1/PPT1/FUCA2/IDUA/ACP5/LIPA/TCIRG1/CD68/CTSA/HEXB/AP3S1/TPP1/NCOA7/AKT1S1/SUMF1/CTSS/CTSO/MITF/RAB7A/TELO2/LAMP1/LGMN/GNS/CTSD/ARSB/M6PR	2.60016873665596
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	19/780	128/9376	1.78429487179487	IMPDH2/NPR1/NME1/ENPP1/GUK1/ADCY3/IMPDH1/ADCY1/FHIT/HPRT1/APRT/PFAS/PRPS2/ITPA/ADSL/NTPCR/AK6/PRPS1/PDE4B	2.69119511473987
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	14/780	85/9376	1.97984917043741	IMPDH2/NME1/ENPP1/GUK1/IMPDH1/HPRT1/APRT/UCK2/TYMP/ITPA/ADSL/NTPCR/AK6/DCTD	2.73351963773148
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	16/780	103/9376	1.8672641274583	C3/FOS/JUN/CALR/IFNGR2/TNFRSF1A/MYD88/SERPINE1/MAPK3/ADCY1/IL1B/CXCL8/GNAO1/PIK3R2/PLCB3/PPP2R1A	2.66590458562661
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	20/780	139/9376	1.72957019000184	FOS/HSPA1B/JUN/MMP2/HSPA1A/HSP90AA1/MAPK3/ADCY3/ADCY1/CALM2/HSP90B1/SHC1/MAP2K2/GNAO1/RARA/PIK3R2/PLCB3/BCL2/CALM3/CTSD	2.61031996451849
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	19/780	130/9376	1.75684418145957	FOS/EDNRB/JUN/MMP2/GNG4/MAPK3/ADCY3/ADCY1/VEGFB/SHC1/MAP2K2/GNB2/ACTA2/GNAO1/PIK3R2/PLCB3/VEGFC/COL1A1/GNG12	2.61749550295469
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	12/780	70/9376	2.06065934065934	ACTB/HLA-C/HLA-A/HLA-B/ACTG1/CD55/SGCE/HLA-F/SNTB1/CYCS/CD40/CAV1	2.68304621238676
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	7/780	31/9376	2.71430934656741	ALDOA/H6PD/GPI/RPIA/PRPS2/G6PD/PRPS1	2.87981853883252
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	14/780	89/9376	1.89086718524921	GJA1/TUBB/HTR2A/TUBA1B/TUBA1C/TUBB6/MAPK3/ADCY3/TUBB4B/ADCY1/MAP2K2/TUBA1A/PLCB3/TUBB3	2.54363609331329
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	5/780	19/9376	3.16329284750337	IDUA/HEXB/HPSE/GNS/ARSB	2.8432073702106
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	27/780	214/9376	1.51660675772825	HLA-C/HLA-A/B2M/FOS/JUN/HLA-B/CFL1/CALR/GNG4/TNFRSF1A/MYD88/MAPK3/CALM2/HLA-F/LIMK2/MAP2K2/CYCS/TAP2/ELOB/TAPBP/GNB2/GNAO1/PIK3R2/BCL2/TAP1/CALM3/GNG12	2.30280180908952
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	17/780	119/9376	1.71721611721612	FOS/MAP3K5/JUN/IL15/MMP14/VCAM1/JUNB/TNFRSF1A/MAP3K8/MAPK3/CXCL2/RPS6KA4/CEBPB/BCL3/IL1B/PIK3R2/VEGFC	2.37177302511456
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	8/780	42/9376	2.28962148962149	PCBP2/SLC39A14/STEAP3/PCBP1/SLC40A1/TP53/LPCAT3/PRNP	2.52311906072572
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	6/780	27/9376	2.67122507122507	ELOVL3/SCP2/ACOT7/TECR/HACD1/ACOT2	2.61950348458637
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	11/780	67/9376	1.97351703023345	ALDOA/LDHA/PKM/ENO1/ADH5/GPI/ALDH2/TPI1/GAPDH/HK2/PGAM1	2.40887450733208
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	10/780	59/9376	2.03737505432421	INSR/NPR1/IRS2/PTGER3/ADCY3/ADCY1/PNPLA2/PIK3R2/ABHD5/IRS1	2.4077339390421
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	19/780	140/9376	1.63135531135531	EGR1/RPS6/SLC8A1/GNG4/SERPINE1/MAPK3/ADCY3/ADCY1/CALM2/MAP2K2/RRAS/GNB2/ACTA2/PLAT/PLCB3/CALM3/KLF2/GNG12/MYLK3	2.26715195866747
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	15/780	103/9376	1.75056011949216	LAMA4/LAMC1/HSPB1/ACTN1/ADCY1/CXCL2/CD1D/PRDX1/IL1B/CXCL8/PIK3R2/PLCB3/RAB7A/COL1A1/ACTN4	2.30716525795517
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	14/780	97/9376	1.73491937615649	FOS/GNG4/CACNA1C/GRIA3/MAPK3/ADCY3/ADCY1/CALM2/PER3/GNB2/GNAO1/PLCB3/CALM3/GNG12	2.19159203614084
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	7/780	37/9376	2.27415107415107	LAMA4/APOL1/VCAM1/MYD88/IL1B/THOP1/PLCB3	2.33914064409024
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	7/780	37/9376	2.27415107415107	GADD45A/MAPK3/TP53/MAP2K2/NTRK1/MYC/RXRA	2.33914064409024
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	10/780	62/9376	1.93879239040529	INSR/SOD2/HSPA1B/HSPA1A/IRS2/ADCY3/ADCY1/AKT1S1/PIK3R2/IRS1	2.23399411517146
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	4/780	15/9376	3.20547008547009	ST3GAL5/ST6GALNAC5/HEXB/ST6GALNAC6	2.57495957023143
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	13/780	89/9376	1.75580524344569	COL6A2/THBS2/LAMA4/TNC/HSPG2/LAMC1/THBS1/TNXB/ITGA1/ITGB5/COL6A1/THBS3/COL1A1	2.15800236957444
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	21/780	166/9376	1.52066728452271	MYL9/INSR/EDNRB/SLC8A1/SLC25A6/NPR1/IRS2/CACNA1C/MAPK3/ADCY3/ADCY1/CALM2/MAP2K2/ATP2B3/SRF/ADRA2A/ATP2B4/PLCB3/IRS1/CALM3/MYLK3	2.03877479215083
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	18/780	138/9376	1.56789297658863	INSR/RPS6/PTPRF/IRS2/PYGL/FLOT1/SORBS1/EIF4EBP1/MAPK3/CALM2/SHC1/MAP2K2/RHEB/HK2/PIK3R2/IRS1/CBLB/CALM3	2.02442549462823
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	23/780	187/9376	1.47845879610586	NAMPT/JUN/CTSB/IFI16/TXN/HSP90AA1/GBP1/GBP2/MYD88/PKN1/MAPK3/CXCL2/GSDMD/CASP4/IL1B/NFKBIB/CXCL8/CASP1/ANTXR2/NOD1/PLCB3/TANK/BCL2	1.99074648147775
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	8/780	47/9376	2.04604473540644	INSR/IRS2/PKM/CACNA1C/MAPK3/HK2/PIK3R2/IRS1	2.16554083063865
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	16/780	120/9376	1.60273504273504	MAP3K5/JUN/MAPKAPK2/NGFR/ARHGDIA/MAPK3/CALM2/SHC1/TP53/MAP2K2/NTRK1/NFKBIB/PIK3R2/BCL2/IRS1/CALM3	2.00165915883395
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	12/780	83/9376	1.73790546802595	GSDME/IFI16/PCBP1/GSDMD/CCL4/POLR2L/IL1B/NFKBIB/CCL4L2/CASP1/POLR2E/POLR2K	2.03397936350938
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	8/780	48/9376	2.0034188034188	AOX1/BCAT2/ALDH2/AACS/ALDH6A1/HIBADH/HSD17B10/ECHS1	2.09939095268755
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	21/780	170/9376	1.48488687782805	ACTB/MYL9/YBX3/MAP3K5/JUN/ACTG1/TUBA1B/ACTN1/TUBA1C/MYL6/TJP2/CDK4/CD1D/ARPC4/CLDN10/TUBA1A/MYL12B/ARPC1A/AMOTL2/ACTN4/PPP2R1A	1.92182634616386
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	13/780	93/9376	1.68028673835125	ACTB/MYL9/INSR/PTPRF/ACTG1/ACTN1/PTPRM/SORBS1/MAPK3/MYL12B/WASF1/NECTIN2/ACTN4	1.98597620188089
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	15/780	112/9376	1.60989010989011	HSPA1B/LDLR/HSPA1A/LAMA4/LAMC1/IFNGR2/TNFRSF1A/MYD88/MAPK3/CYCS/NFKBIB/GNAO1/BCL2/CD40/IL10RB	1.95589738065125
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	11/780	75/9376	1.76300854700855	MAP3K5/MGST1/GSTT2B/MAPK3/GSTP1/TP53/CYCS/ERCC1/PIK3R2/BCL2/GSTO1	1.99838862258826
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	27/780	232/9376	1.39893899204244	ACTB/CXCL12/MYL9/ACTG1/F2R/CFL1/PFN1/FGF7/GSN/ACTN1/ITGA1/MAPK3/ITGB5/LIMK2/ARPC4/MAP2K2/INSRR/RGCC/MYL12B/ARPC1A/RRAS/PIK3R2/WASF1/GNG12/ACTN4/MYLK3/DIAPH2	1.85339123969028
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	13/780	94/9376	1.66241134751773	JUND/FOSB/FOS/JUN/HSP90AA1/MAPK3/CXCL2/CEBPB/HSP90B1/IL1B/CXCL8/IL17RC/SRSF1	1.94426583379943
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	14/780	105/9376	1.60273504273504	CXCL12/GADD45A/VCAM1/TNFRSF1A/MYD88/CXCL2/TNFSF14/CCL4/IL1B/CXCL8/CCL4L2/BCL2/CD40/PLAU	1.87086537347475
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	24/780	205/9376	1.40727954971857	HLA-C/HLA-A/B2M/VIM/GADD45A/JUN/HLA-B/CALR/MYD88/ISG15/CDK4/HLA-F/TP53/MYC/CYCS/TAP2/NFKBIB/TAPBP/PSMC3/SEM1/PIK3R2/BCL2/TAP1/CD40	1.77601211436649
NA	NA	hsa04517	IgSF CAM signaling	33/780	299/9376	1.32667867249807	ACTB/MYL9/TUBB/PTPRF/ACTG1/TUBA1B/ACTN1/LRFN4/NLGN4X/NCAM2/SORBS1/TUBA1C/TUBB6/MYL6/TJP2/MAPK3/TUBB4B/PPFIA2/PMP22/ARPC4/MAP2K2/CSK/TUBA1A/PLXNA1/MYL12B/ARPC1A/PIK3R2/TUBB3/KDR/NECTIN2/CNTNAP1/ACTN4/MYLK3	1.72929842001945
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	15/780	116/9376	1.55437665782493	SLC38A2/GNG4/CACNA1C/GRIA3/MAPK3/ADCY3/ADCY1/GNB2/GNAO1/PLCB3/GLUL/HOMER1/GNG12/GRM7/GRK2	1.80972744782992
Organismal Systems	Digestive system	hsa04978	Mineral absorption	9/780	61/9376	1.77351828499369	SLC8A1/MT1X/MT2A/CYBRD1/STEAP1/SLC40A1/ATP2B3/ATOX1/ATP2B4	1.82569744741158
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	12/780	89/9376	1.62074330164218	GABRA2/SLC38A2/GNG4/CACNA1C/GABRE/ADCY3/ADCY1/GNB2/SLC38A5/GNAO1/GLUL/GNG12	1.77236864583559
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	12/780	90/9376	1.60273504273504	INSR/SOD2/IRS2/EIF4EBP1/ADCY3/ADCY1/TP53/AKT1S1/RHEB/PIK3R2/ADIPOR1/IRS1	1.73068525283428
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	20/780	170/9376	1.41417797888386	ACTB/IGF2/GADD45A/ACTG1/MGST1/WNT5B/GSTT2B/MAPK3/CDK4/HGF/LRP5/GSTP1/SHC1/NFE2L2/TP53/MAP2K2/MYC/PIK3R2/TXNRD2/GSTO1	1.64157494916199
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	23/780	201/9376	1.37548156652634	IGFBP3/ID2/NUPR1/GADD45A/NFKBIZ/MEIS1/GRIA3/NGFR/PBX1/MAF/CEBPB/BCL6/WT1/TP53/NTRK1/MYC/CXCL8/PLAT/RARA/MITF/CD40/RXRA/PLAU	1.62094526256798
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	11/780	82/9376	1.61250781738587	IMPDH2/NME1/MGST1/GSTT2B/IMPDH1/HPRT1/UCK2/GSTP1/TYMP/ITPA/GSTO1	1.67803866757081
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	12/780	93/9376	1.55103391232423	EGR1/JUN/MMP2/MMP14/CACNA1C/MAPK3/ADCY3/ADCY1/CALM2/MAP2K2/PLCB3/CALM3	1.6086455528407
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	12/780	93/9376	1.55103391232423	GADD45A/LAMA4/LAMC1/CDK4/FHIT/TP53/MYC/CYCS/PIK3R2/BCL2/RXRA/CKS2	1.6086455528407
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	18/780	154/9376	1.404995004995	ACTB/MYL9/FOS/JUN/ACTG1/NPR1/CACNA1C/EEF2/MYL6/MAPK3/ADCY3/ADCY1/CALM2/MAP2K2/GNAO1/PLCB3/CALM3/MYLK3	1.52644866880992
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	16/780	134/9376	1.43528511289705	PLA2G2A/MYL9/CALD1/NPR1/CACNA1C/MYL6/MAPK3/ADCY3/ADCY1/CALM2/PTGIR/MAP2K2/ACTA2/PLCB3/CALM3/MYLK3	1.52872007038438
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	7/780	47/9376	1.79028914348063	LDHA/PKM/PC/ADH5/ALDH2/FH/MDH2	1.63607095403315
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	12/780	95/9376	1.51838056680162	CXCL12/FOS/JUN/IL15/CTSK/CTSL/ACP5/CXCL2/TCIRG1/IL1B/CXCL8/TEK	1.52967040611211
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	5/780	30/9376	2.0034188034188	SHMT2/ABCC3/IL1B/FPGS/GGH	1.65811523743177
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	11/780	86/9376	1.53750745378652	ACTB/GJA1/ACTG1/SLC8A1/CACNA1C/DES/SGCE/ITGA1/ITGB5/PKP2/SNTB1	1.50837941143685
Organismal Systems	Immune system	hsa04611	Platelet activation	15/780	126/9376	1.43101343101343	ACTB/ACTG1/F2R/RASGRP2/APBB1IP/MAPK3/ADCY3/ADCY1/PTGIR/P2RY1/MYL12B/PIK3R2/PLCB3/COL1A1/MYLK3	1.46720212034409
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	18/780	157/9376	1.378147966683	BSG/CALR/MAPKAPK2/PROS1/HIF1A/THBS1/PBX1/MAPK3/LIPA/ITGB5/CEBPB/MAP2K2/CASP1/LRP1/RAB7A/ELMO1/RXRA/NR1H2	1.43931027039491
NA	NA	hsa04981	Folate transport and metabolism	5/780	31/9376	1.93879239040529	SHMT2/ABCC3/MTHFD1/MTHFS/FPGS	1.57705010208188
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	12/780	98/9376	1.47189952904239	LDLR/NPR1/NR4A1/CACNA1C/ADCY3/ADCY1/CALM2/STAR/ATP2B3/ATP2B4/PLCB3/CALM3	1.41455596303643
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	13/780	109/9376	1.43363914373089	FOS/JUN/CTSK/MAP3K8/MYD88/MAPK3/CCL4/MAP2K2/IL1B/CXCL8/CCL4L2/PIK3R2/CD40	1.37169287184189
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	4/780	23/9376	2.09052396878484	ENPEP/CTSA/PREP/THOP1	1.57727856883799
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	12/780	99/9376	1.45703185703186	FOS/JUN/MMP2/MAPK3/CDK4/ADCY3/ADCY1/SHC1/TP53/MAP2K2/PIK3R2/BCL2	1.37703515718362
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	5/780	32/9376	1.87820512820513	TNFRSF1A/NGFR/BOK/CYCS/BCL2	1.4989573611076
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	9/780	70/9376	1.54549450549451	JUN/EPAS1/HIF1A/MAPK3/HGF/MAP2K2/ELOB/PIK3R2/FH	1.37988410674346
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	7/780	51/9376	1.64987430869784	ACTB/ACTG1/TJP2/PDIA4/ADCY3/TCIRG1/ERO1A	1.40176358083552
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	12/780	101/9376	1.42817974105103	EDNRB/WNT5B/MAPK3/ADCY3/ADCY1/CALM2/MAP2K2/KITLG/GNAO1/MITF/PLCB3/CALM3	1.30321052589335
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	14/780	122/9376	1.37940311055065	ACTB/ACTG1/DIO3/HIF1A/MAPK3/MED24/TP53/PLCD1/MAP2K2/MYC/RHEB/PIK3R2/PLCB3/RXRA	1.27057641947453
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	7/780	52/9376	1.6181459566075	INSR/LDLR/ADCY3/ADCY1/STAR/HSD17B7/ACOT2	1.34640683707573
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	7/780	52/9376	1.6181459566075	TSPO/LDLR/NPC2/LIPA/PLTP/STAR/LRP1	1.34640683707573
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	16/780	144/9376	1.33561253561254	KCND3/MAP3K5/SLC25A6/PSMB3/GRIA3/PSMA4/CYCS/PSMC3/SEM1/PIK3R2/PLCB3/PSMB2/PSMB7/PSMA2/PSMA3/PSMB4	1.22252080367799
Human Diseases	Cancer: specific types	hsa05218	Melanoma	9/780	73/9376	1.48198103266596	GADD45A/FGF7/MAPK3/CDK4/HGF/TP53/MAP2K2/PIK3R2/MITF	1.24527309098114
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	9/780	73/9376	1.48198103266596	GADD45A/MAPK3/CDK4/HGF/FHIT/TP53/MAP2K2/PIK3R2/RXRA	1.24527309098114
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	6/780	44/9376	1.63916083916084	DDOST/RPN1/HEXB/MAN1C1/ALG3/B4GALT3	1.28007043654538
Genetic Information Processing	Transcription	hsa03040	Spliceosome	25/780	243/9376	1.23667827371531	HSPA1B/HSPA1A/SNRPB/SNRPF/HNRNPA1/PCBP1/SNRPG/PQBP1/THOC6/LSM4/SNRPD2/SNRPA/PPIH/LSM5/SNRPD1/EIF4A3/THOC3/SART1/SRSF3/SF3B6/SF3A1/PRPF31/ALYREF/SNRPC/SRSF1	1.12600297268544
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	13/780	115/9376	1.35884057971014	JUND/FOS/EGR1/MMP14/MAPK3/ADCY3/ADCY1/LRP5/AKAP13/PLCB3/BCL2/RXRA/PDE4B	1.16628922633098
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	7/780	54/9376	1.55821462488129	AHCY/ADI1/LDHA/SRM/BCAT2/AMD1/MDH2	1.23916254317605
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	12/780	105/9376	1.37377289377289	ACTB/TPM2/ACTG1/SLC8A1/CACNA1C/DES/SGCE/ITGA1/ADCY3/ADCY1/ITGB5/SNTB1	1.16017605568449
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	33/780	333/9376	1.19122199122199	HLA-C/COL6A2/HLA-A/THBS2/LAMA4/TNC/HLA-B/PKM/LAMC1/TNFRSF1A/WNT5B/THBS1/ISG15/EIF4EBP1/TNXB/ITGA1/MAPK3/CDK4/TCIRG1/ITGB5/HLA-F/COL6A1/TP53/MAP2K2/BCAP31/TUBG1/RHEB/PIK3R2/THBS3/COL1A1/PPP2R3B/PPP2R1A/TADA3	1.07025785441124
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	18/780	169/9376	1.28029130632681	CTSB/IRS2/CTSL/UBB/HIF1A/MAPK3/MAP2K2/AKT1S1/RRAS/RHEB/PIK3R2/TANK/BCL2/IRS1/UBC/RAB7A/LAMP1/CTSD	1.10758902704859
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	9/780	75/9376	1.44246153846154	GPX1/GPX3/PDIA4/ADCY3/ADCY1/HSP90B1/PLCB3/GSR/HSPA5	1.15884691968533
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	8/780	65/9376	1.47944773175542	LDLR/NR4A1/CACNA1C/PBX1/ADCY3/ADCY1/STAR/PLCB3	1.16838109021594
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	15/780	138/9376	1.30657748049052	ACTB/FOS/JUN/ACTG1/MYD88/PKN1/MAPK3/ARPC4/MAP2K2/IL1B/CXCL8/CASP1/ARPC1A/PIK3R2/ELMO1	1.09288773267131
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	17/780	160/9376	1.27717948717949	HLA-C/HLA-A/SDC3/PTPRF/HLA-B/CDH3/VCAM1/SDC2/NLGN4X/NCAM2/PTPRM/HLA-F/CLDN10/NRXN2/CD40/NECTIN2/CNTNAP1	1.06520839710358
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	9/780	76/9376	1.42348178137652	ACTB/ACTG1/ADCY3/ADCY1/CALM2/SLC4A2/PLCB3/CALM3/MYLK3	1.11656700279263
Human Diseases	Cancer: specific types	hsa05214	Glioma	9/780	76/9376	1.42348178137652	GADD45A/MAPK3/CDK4/CALM2/SHC1/TP53/MAP2K2/PIK3R2/CALM3	1.11656700279263
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	20/780	193/9376	1.24564899694433	CXCL12/RASGRP2/GNG4/MAPK3/ADCY3/ADCY1/CXCL2/CCL4/SHC1/NFKBIB/CXCL13/CXCL8/CCL4L2/GNB2/PIK3R2/PLCB3/ELMO1/CXCL16/GNG12/GRK2	1.03869034234377
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	10/780	87/9376	1.38166814028883	TPM2/MT-CO2/SLC8A1/CACNA1C/COX6A1/UQCRQ/COX6C/UQCRC1/COX5B/COX7A2L	1.0773226477179
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	10/780	87/9376	1.38166814028883	FOS/GADD45A/JUN/MAPK3/TP53/MAP2K2/MYC/CYCS/PIK3R2/BCL2	1.0773226477179
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	5/780	37/9376	1.62439362439362	AOX1/MAOB/MIF/ADH5/COMT	1.14628832825264
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	9/780	78/9376	1.38698224852071	ACTB/ACTG1/ARPC4/SHC1/ARPC1A/PIK3R2/WASF1/CAV1/ELMO1	1.03378043899336
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	9/780	78/9376	1.38698224852071	C3/EEF1A1/FOS/JUN/IFNGR2/MYD88/MAPK3/IL1B/NFKBIB	1.03378043899336
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	15/780	142/9376	1.26977248104009	JUND/FOSB/FOS/JUN/CTSK/IFNGR2/JUNB/TNFRSF1A/ACP5/FOSL2/MAPK3/TMEM64/IL1B/PIK3R2/MITF	0.9757344062056
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	11/780	100/9376	1.32225641025641	CXCL12/TNFRSF1A/CXCL2/TNFRSF14/TNFSF14/IL6ST/CCL4/CXCL13/CXCL8/CCL4L2/IL10RB	0.97590137782017
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	8/780	69/9376	1.39368264585656	FOSB/FOS/MAOB/JUN/CACNA1C/GRIA3/CALM2/CALM3	0.988668495624169
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	13/780	122/9376	1.28087431693989	IGFBP3/FOS/IRS2/JUNB/CACNA1C/MAPK3/ADCY3/ADCY1/SHC1/MAP2K2/PIK3R2/PLCB3/IRS1	0.940615071452337
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	14/780	133/9376	1.26531713900135	INSR/FBXO32/SOD2/GADD45A/IRS2/PRMT1/MAPK3/BCL6/MAP2K2/PIK3R2/CSNK1E/IRS1/HOMER1/KLF2	0.928259463742957
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	14/780	133/9376	1.26531713900135	FOS/MAOB/GNG4/CACNA1C/GRIA3/CALM2/COMT/GNB2/GNAO1/PLCB3/PPP2R3B/CALM3/GNG12/PPP2R1A	0.928259463742957
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	9/780	80/9376	1.35230769230769	RPS6/EIF4EBP1/MAPK3/HGF/SHC1/MAP2K2/PIK3R2/BCL2/KDR	0.953243379778036
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	5/780	39/9376	1.54109138724523	AHCY/SHMT2/MTHFD2/MTHFD1/MTHFS	1.01996197543965
Human Diseases	Immune disease	hsa05330	Allograft rejection	5/780	39/9376	1.54109138724523	HLA-C/HLA-A/HLA-B/HLA-F/CD40	1.01996197543965
Human Diseases	Substance dependence	hsa05032	Morphine addiction	10/780	91/9376	1.32093547478163	GABRA2/GNG4/GABRE/ADCY3/ADCY1/GNB2/GNAO1/PDE4B/GNG12/GRK2	0.926685148764682
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	7/780	60/9376	1.40239316239316	MAPKAPK2/HSPB1/SH2D2A/MAPK3/MAP2K2/PIK3R2/KDR	0.941881385166096
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	4/780	30/9376	1.60273504273504	PC/SDHD/FH/MDH2	0.995999033591896
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	13/780	125/9376	1.25013333333333	SPTSSA/MAP3K5/TNFRSF1A/MAPK3/CERS2/TP53/MAP2K2/PIK3R2/PLCB3/BCL2/PPP2R3B/CTSD/PPP2R1A	0.848041240834851
Organismal Systems	Digestive system	hsa04970	Salivary secretion	10/780	93/9376	1.2925282602702	CST3/ADCY3/ADCY1/CALM2/SLC4A2/ATP2B3/ATP2B4/PLCB3/LYZ/CALM3	0.853984254760323
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	18/780	181/9376	1.19541011474713	C3/IFNGR2/TNFRSF1A/MYD88/MAPK3/TCIRG1/CALM2/CEBPB/CYCS/IL1B/CTSS/BCL2/NFYC/RAB7A/LAMP1/CALM3/IL10RB/CTSD	0.799641263184261
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	12/780	115/9376	1.2543143812709	FOS/GNG4/CACNA1C/MAPK3/ADCY3/ADCY1/GNB2/GNAO1/PIK3R2/PLCB3/BCL2/GNG12	0.826562378248489
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	9/780	83/9376	1.30342910101946	SOD2/ECH1/GSTK1/MPV17/PRDX1/SCP2/PEX5/PEX19/GNPAT	0.836378854073063
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	3/780	21/9376	1.71721611721612	CHST11/CHSY3/UST	0.99111152890744
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	3/780	21/9376	1.71721611721612	ENPP1/BCAT2/ALDH2	0.99111152890744
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	23/780	238/9376	1.16164619694031	PLA2G2A/IGF2/INSR/RASGRP2/GNG4/FGF7/NGFR/MAPK3/HGF/CALM2/VEGFB/SHC1/MAP2K2/NTRK1/KITLG/RRAS/GNB2/PIK3R2/VEGFC/TEK/KDR/CALM3/GNG12	0.760874674900029
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	4/780	31/9376	1.55103391232423	OXA1L/BAG6/SRPRB/HSPA5	0.925665883706565
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	11/780	105/9376	1.25929181929182	JUN/UBB/HIF1A/PHB2/TP53/CCZ1/FKBP8/RRAS/MITF/UBC/RAB7A	0.804831396789356
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	11/780	105/9376	1.25929181929182	JUN/MAPKAPK2/MAPK3/CALM2/BCL3/IL1B/CASP1/RRAS/PIK3R2/CBLB/CALM3	0.804831396789356
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	12/780	116/9376	1.24350132625995	ACTB/CXCL12/MYL9/MMP2/ACTG1/VCAM1/ACTN1/CLDN10/MYL12B/THY1/PIK3R2/ACTN4	0.794894639764529
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	20/780	205/9376	1.17273295809881	C3/HLA-C/HLA-A/JUN/HLA-B/MAPKAPK2/PKM/GSN/ACTN1/MAPK3/CDK4/IL6ST/HLA-F/TP53/RANBP1/SRF/HDAC7/PIK3R2/ACTN4/VAC14	0.75323159816354
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	8/780	73/9376	1.31731647348086	AOX1/MAOB/MGST1/GSTT2B/GSTK1/ADH5/GSTP1/GSTO1	0.819836547436499
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/780	12/9376	2.0034188034188	NCAM2/NGFR	1.04767575041339
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	21/780	217/9376	1.16327543424318	FOS/JUN/MGST1/CACNA1C/FGF7/HSP90AA1/EIF4EBP1/GSTT2B/MAPK3/ADCY3/ADCY1/HSP90B1/BCL6/MAP2K2/MYC/EPHX1/PIK3R2/BCL2/RXRA/PAQR7/GSTO1	0.733012568073507
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	11/780	106/9376	1.24741170778907	HSP90AA1/MAPK3/HSP90B1/GSTP1/TP53/MAP2K2/INSRR/PLAT/PIK3R2/BCL2/PLAU	0.771645892492226
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	7/780	63/9376	1.33561253561254	POLD4/POLR2L/RAD23A/ERCC1/RPA2/POLR2E/POLR2K	0.80509732444998
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	5/780	42/9376	1.43101343101343	AOX1/MAOB/ALDH2/GCDH/ECHS1	0.843269294107346
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	3/780	22/9376	1.63916083916084	MAOB/ALDH2/HNMT	0.904081436626396
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	28/780	298/9376	1.12944415763208	CXCL12/IL15/OSMR/IL15RA/IL32/IFNGR2/CSF3R/TNFRSF1A/NGFR/IL13RA1/CXCL2/CLCF1/TNFRSF14/TNFSF14/IL6ST/CCL4/IL1B/CXCL13/CXCL8/CCL4L2/TNFRSF21/IL17RC/RELT/IL1RL1/CD40/CXCL16/TNFSF12/IL10RB	0.684038006452349
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	11/780	109/9376	1.2130792754646	FOS/JUN/IFNGR2/HIF1A/HSP90AA1/MAPK3/IL6ST/IL1B/NFKBIB/RARA/RXRA	0.674015082626876
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	3/780	23/9376	1.56789297658863	POLD4/RPA2/SSBP1	0.821371603931784
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	5/780	44/9376	1.36596736596737	HLA-C/HLA-A/HLA-B/HLA-F/IL1B	0.732936026760121
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	10/780	99/9376	1.21419321419321	FOS/JUN/HIF1A/EIF4EBP1/MAPK3/MAP2K2/RHEB/CHKB/PIK3R2/WASF1	0.645363297626008
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	10/780	99/9376	1.21419321419321	ACTB/TPM2/ACTG1/SLC8A1/CACNA1C/DES/SGCE/ITGA1/ITGB5/SNTB1	0.645363297626008
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	8/780	77/9376	1.24888444888445	GADD45A/MAPK3/CDK4/SHC1/TP53/MAP2K2/MYC/PIK3R2	0.660556143667713
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	12/780	122/9376	1.18234552332913	INSR/IRS2/EEF2/EIF4EBP1/TBC1D1/AKT1S1/RHEB/PIK3R2/ADIPOR1/IRS1/PPP2R3B/PPP2R1A	0.610653723430147
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	5/780	45/9376	1.33561253561254	HLA-C/HLA-A/HLA-B/HLA-F/IL1B	0.679774818036672
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	6/780	56/9376	1.28791208791209	DDOST/RPN1/GANAB/MAN1C1/ALG3/B4GALT3	0.650924611359877
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	8/780	78/9376	1.23287310979619	ENO1/PABPC1/LSM4/MPHOSPH6/EXOSC5/LSM5/PABPC4/CNOT9	0.622094854725529
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	7/780	67/9376	1.25587447378492	CACNA1C/MAPK3/ADCY1/CALM2/MAP2K2/PLCB3/CALM3	0.633136840790247
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/780	14/9376	1.71721611721612	CHST2/B4GALT3	0.808936582623715
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	9/780	90/9376	1.20205128205128	FOS/JUN/IFNGR2/HIF1A/MYD88/MAPK3/MAP2K2/NFKBIB/PIK3R2	0.58016731958313
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	7/780	68/9376	1.23740573152338	PIM1/EIF4EBP1/MAPK3/MAP2K2/MYC/RARA/PIK3R2	0.5918371257078
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	6/780	57/9376	1.26531713900135	PPT1/ELOVL3/SCP2/TECR/HACD1/ECHS1	0.605205426785727
Human Diseases	Infectious disease: viral	hsa05162	Measles	13/780	136/9376	1.14901960784314	FOS/HSPA1B/JUN/HSPA1A/MYD88/CDK4/TP53/CYCS/IL1B/NFKBIB/PIK3R2/BCL2/CBLB	0.527304673978258
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	4/780	36/9376	1.33561253561254	PYGL/ENPP1/GPI/HK2	0.607716072412362
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	14/780	149/9376	1.12944415763208	INSR/F2R/MAPK3/ADCY3/ADCY1/SHC1/MAP2K2/KITLG/CXCL8/RRAS/RHEB/PIK3R2/PLCB3/GRM7	0.479766658945363
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	16/780	173/9376	1.11172372906477	ACTB/ACTG1/SLC25A6/IFNGR2/TNFRSF1A/MYD88/MAPK3/CDK4/MAP2K2/CYCS/IL1B/DNAJB1/NFKBIB/CXCL8/CASP1/PIK3R2	0.446774625698438
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	6/780	59/9376	1.22242503259452	GADD45A/MAPK3/TP53/MAP2K2/MYC/PIK3R2	0.516245592795034
NA	NA	hsa03272	Virion - Hepatitis viruses	5/780	48/9376	1.25213675213675	LDLR/HSPG2/CD81/CLDN10/LAMP1	0.527530094585032
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	4/780	37/9376	1.2995148995149	ASS1/NIT2/ADSL/GLUL	0.549862170333843
Organismal Systems	Nervous system	hsa04730	Long-term depression	6/780	60/9376	1.20205128205128	GRIA3/MAPK3/MAP2K2/GNAO1/PLCB3/PPP2R1A	0.472941290257572
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/780	16/9376	1.5025641025641	MAOB/MIF	0.606035782801289
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	4/780	38/9376	1.26531713900135	GPI/HEXB/GALK1/HK2	0.493645184872198
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	4/780	38/9376	1.26531713900135	AOX1/NNMT/NAMPT/ENPP1	0.493645184872198
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	4/780	38/9376	1.26531713900135	INSR/MAPK3/PIK3R2/IRS1	0.493645184872198
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	4/780	38/9376	1.26531713900135	TAP2/UNG/TAP1/CD40	0.493645184872198
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	5/780	50/9376	1.20205128205128	MAOB/SRM/AMD1/ALDH2/PYCR2	0.431502824870883
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	14/780	154/9376	1.09277389277389	TPM2/SLC8A1/CACNA1C/MAPK3/ADCY3/ADCY1/CALM2/ATP2B3/ATP2B4/PLCB3/BCL2/PPP2R3B/CALM3/PPP2R1A	0.349669954884429
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	10/780	108/9376	1.11301044634378	EEF1A1/THOC6/RAN/IPO4/NUP35/EIF4A3/THOC3/SUMO3/RANGAP1/ALYREF	0.355813311400835
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	3/780	28/9376	1.28791208791209	FPGS/GGH/MOCOS	0.459583363192871
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	2/780	17/9376	1.41417797888386	SCP2/HSD3B7	0.514850901686832
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	22/780	250/9376	1.05780512820513	HLA-C/HLA-A/HSPA1B/LDLR/HSPA1A/HLA-B/PSD/SH3KBP1/RAB31/EPN3/HLA-F/PSD3/ARPC4/ARPC1A/CAPZB/MVB12A/CAV1/RAB7A/CBLB/GRK2/ARF3/VPS37C	0.279049261173604
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	14/780	156/9376	1.07876397107166	LDLR/CD81/TNFRSF1A/MAPK3/CDK4/CLDN10/TP53/MAP2K2/MYC/CYCS/PIK3R2/PSME3/RXRA/PPP2R1A	0.298819667924694
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	8/780	86/9376	1.11818723911747	JUN/EIF4EBP1/MAPK3/SHC1/MAP2K2/MYC/PIK3R2/CBLB	0.331662746113583
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	15/780	168/9376	1.07326007326007	AOX1/PIM1/IL15/OSMR/IL15RA/MCL1/IFNGR2/CSF3R/IL13RA1/CLCF1/IL6ST/MYC/PIK3R2/BCL2/IL10RB	0.288618436902944
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	11/780	122/9376	1.08381672971837	FOS/JUN/MAP3K8/MAPK3/CDK4/MAP2K2/NFKBIB/PIK3R2/CBLB/PPP2R3B/PPP2R1A	0.280692375407956
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	9/780	99/9376	1.09277389277389	HTR2A/ADCY3/ADCY1/CALM2/NTRK1/IL1B/PIK3R2/PLCB3/CALM3	0.279527367847202
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	14/780	158/9376	1.06510873093152	INSR/RPS6/TNFRSF1A/WNT5B/EIF4EBP1/MAPK3/LRP5/NPRL3/MAP2K2/AKT1S1/RHEB/PIK3R2/IRS1/TELO2	0.24861891000331
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	7/780	76/9376	1.10715249662618	FABP5/SORBS1/DBI/PLTP/SCP2/UBC/RXRA	0.282522052331852
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	4/780	41/9376	1.17273295809881	MAOB/GCAT/SHMT2/PGAM1	0.3338833127354
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	4/780	41/9376	1.17273295809881	POLD4/SEM1/RPA2/SSBP1	0.3338833127354
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	2/780	18/9376	1.33561253561254	FUCA2/HEXB	0.42930667614694
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	2/780	18/9376	1.33561253561254	CD320/PRDX1	0.42930667614694
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	22/780	254/9376	1.04114677972946	EDNRB/F2R/SLC8A1/SLC25A6/HTR2A/CACNA1C/FGF7/PTGER3/ADCY3/ADCY1/HGF/CALM2/VEGFB/PLCD1/NTRK1/ATP2B3/ATP2B4/PLCB3/VEGFC/KDR/CALM3/MYLK3	0.200259170155567
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	6/780	65/9376	1.10958579881657	TRPC4/CACNA1C/MAPK3/MAP2K2/PIK3R2/PLCB3	0.267053041683386
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	3/780	30/9376	1.20205128205128	PIGU/PIGT/PIGK	0.333882829752019
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	13/780	148/9376	1.05585585585586	FOS/GADD45A/JUN/FGF7/WNT5B/MAPK3/CDK4/LRP5/SHC1/TP53/MAP2K2/MYC/PIK3R2	0.206314860996528
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	5/780	54/9376	1.11301044634378	FANCE/ERCC1/RPA2/TELO2/CENPX	0.250868224970994
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	5/780	54/9376	1.11301044634378	HLA-C/HLA-A/HLA-B/HLA-F/CD40	0.250868224970994
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	13/780	150/9376	1.04177777777778	GADD45A/FGF7/WNT5B/MAPK3/HGF/LRP5/SHC1/TP53/MAP2K2/MYC/PIK3R2/BCL2/RXRA	0.155370647633062
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	3/780	31/9376	1.16327543424318	ALDH2/ALDH6A1/ECHS1	0.274281665331246
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	3/780	31/9376	1.16327543424318	SHMT2/GLUL/MDH2	0.274281665331246
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	4/780	43/9376	1.11818723911747	ADH5/ALDH2/GCDH/ECHS1	0.233980098009374
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	5/780	55/9376	1.09277389277389	PSAP/HEXB/CERS2/ACER3/UGCG	0.207855062583343
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7/780	79/9376	1.06510873093152	MGST1/GSTT2B/GSTK1/ADH5/GSTP1/EPHX1/GSTO1	0.175051604847925
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	9/780	103/9376	1.05033607169529	COL6A2/SLC8A1/SLC38A2/SLC1A5/COL15A1/COL6A1/COL21A1/COL1A1/KCNE3	0.154729291926546
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	10/780	115/9376	1.04526198439242	MAOB/DUSP1/GNG4/HTR2A/CACNA1C/MAPK3/GNB2/GNAO1/PLCB3/GNG12	0.147108682083503
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	3/780	32/9376	1.12692307692308	LDHA/ALDH6A1/ECHS1	0.216637633211172
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/780	20/9376	1.20205128205128	LIPA/HSD17B7	0.272468460474608
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	19/780	226/9376	1.01057408668028	MYL9/FOS/JUN/F2R/NPR1/CACNA1C/PTGER3/GRIA3/MAPK3/ADCY3/ADCY1/CALM2/MAP2K2/ATP2B3/RRAS/ATP2B4/PIK3R2/CALM3/PDE4B	0.0484698052622665
Organismal Systems	Endocrine system	hsa04924	Renin secretion	6/780	69/9376	1.04526198439242	CTSB/NPR1/CACNA1C/CALM2/PLCB3/CALM3	0.113667946731191
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	13/780	154/9376	1.01471861471861	DHRS3/NME1/SHMT2/MTHFD2/BCAT2/ALDH2/MTHFD1/CPOX/COQ2/FPGS/ADSL/AK6/GGH	0.0554752764030574
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	13/780	155/9376	1.00817204301075	LDLR/NR4A1/CACNA1C/WNT5B/PBX1/MAPK3/CDK4/ADCY3/ADCY1/MAP2K2/STAR/PLCB3/FH	0.0309024005842604
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	6/780	70/9376	1.03032967032967	IRS2/TNFRSF1A/NFKBIB/ADIPOR1/IRS1/RXRA	0.0767220011001603
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	6/780	70/9376	1.03032967032967	MGST1/GSTT2B/GSTK1/GSTP1/EPHX1/GSTO1	0.0767220011001603
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	9/780	107/9376	1.01107117181884	LDHA/PKM/PYGL/PRMT1/CALM2/PPP4C/PLCB3/CALM3/PGAM1	0.034693952115791
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	12/780	144/9376	1.0017094017094	ID2/ID1/ID4/PCGF5/MEIS1/WNT5B/MAPK3/ID3/IL6ST/MAP2K2/MYC/PIK3R2	0.00622676130905592
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	12/780	144/9376	1.0017094017094	C3/MAP3K5/C2/TNFRSF1A/MYD88/CXCL2/ADH5/ALDH2/IL1B/CXCL8/ADIPOR1/IL17RC	0.00622676130905592
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	3/780	34/9376	1.0606334841629	POLR2L/POLR2E/POLR2K	0.106688298241376
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	3/780	34/9376	1.0606334841629	PER3/CSNK1E/BHLHE40	0.106688298241376
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	6/780	71/9376	1.01581798483207	JUN/CXCL2/TCIRG1/CSK/CXCL8/NOD1	0.0403001698488726
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	5/780	59/9376	1.0186875271621	NME1/ENPP1/UCK2/TYMP/DCTD	0.0433735062332676
Cellular Processes	Cell motility	hsa04814	Motor proteins	16/780	194/9376	0.991382500660851	ACTB/MYL9/TPM2/TUBB/ACTG1/TUBA1B/TUBA1C/TUBB6/MYL6/TUBB4B/TUBA1A/MYL12B/TUBG1/CAPZB/ACTA2/TUBB3	-0.036534083384357
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	9/780	109/9376	0.992519407198306	INSR/PTPRF/IRS2/TNFRSF1A/PYGL/SLC27A3/PIK3R2/IRS1/NR1H2	-0.0236627065881373
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	3/780	35/9376	1.03032967032967	ALDOA/TPI1/HK2	0.0541489153828728
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	15/780	184/9376	0.979933110367893	CXCL12/MYL9/TRPC4/CFL1/WNT5B/MAPK3/LIMK2/RHOD/PLXNA1/MYL12B/RRAS/EPHB6/PIK3R2/SEMA3B/CDK5	-0.0828073147797333
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	4/780	48/9376	1.0017094017094	HK2/PIK3R2/PLCB3/SLC2A5	0.00357647521752569
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	8/780	98/9376	0.981266352694924	CFL1/GSN/MAPK3/LIMK2/ARPC4/ARPC1A/PIK3R2/WASF1	-0.0561555815887162
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/780	10/9376	1.20205128205128	ETHE1	0.192561415562416
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/780	23/9376	1.04526198439242	ASS1/GLUL	0.06546463902558
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	3/780	36/9376	1.0017094017094	POLD4/RPA2/SSBP1	0.00309532804284732
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	4/780	49/9376	0.981266352694924	FOSB/MAOB/JUN/CDK5	-0.0396035509312081
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	3/780	37/9376	0.974636174636175	GPI/GALK1/HK2	-0.0465639875849574
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	4/780	50/9376	0.961641025641026	CXCL12/IL15/IL15RA/CD40	-0.0819198256353859
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	5/780	63/9376	0.954008954008954	AASS/ALDH2/PLOD2/GCDH/ECHS1	-0.110327428647645
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	4/780	51/9376	0.942785319255907	PLA2G2A/ENPP2/LPCAT4/GDPD3	-0.12341071909259
Organismal Systems	Digestive system	hsa04976	Bile secretion	7/780	90/9376	0.934928774928775	LDLR/ADCY3/ABCC3/ADCY1/SLC4A2/EPHX1/RXRA	-0.186844635917635
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	8/780	103/9376	0.933632063729151	PABPC1/DAZAP1/EIF4A3/PABPC4/CPSF1/PPP2R3B/ALYREF/PPP2R1A	-0.204010035744892
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	7/780	91/9376	0.92465483234714	FOS/JUN/CD81/MAPK3/MAP2K2/NFKBIB/PIK3R2	-0.217555407181454
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/780	12/9376	1.0017094017094	COQ2	0.00178479684908586
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4/780	53/9376	0.907208514755685	SLC8A1/ATP2B3/ATP2B4/PLCB3	-0.204057684852482
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	2/780	27/9376	0.890408357075024	AACS/ECHS1	-0.171775600705346
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	3/780	41/9376	0.879549718574109	GABRA2/GABRE/GRIA3	-0.232823772747422
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	5/780	68/9376	0.883861236802413	RDH10/AOX1/DHRS3/ADH5/ALDH1A1	-0.289526421089585
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	4/780	56/9376	0.858608058608059	GAS1/CSNK1E/BCL2/GRK2	-0.319665267156377
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/780	29/9376	0.829000884173298	TEAD4/CSNK1E	-0.277805908687388
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/780	29/9376	0.829000884173298	CALM2/CALM3	-0.277805908687388
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	12/780	163/9376	0.884945729117508	FOS/JUN/HSPG2/MYD88/MAPK3/TP53/MAP2K2/MYC/CYCS/CXCL8/PIK3R2/BCL2	-0.446355352823981
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	5/780	71/9376	0.846514987360058	FOS/MAPK3/SHC1/MAP2K2/PIK3R2	-0.391040460862349
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	3/780	44/9376	0.81958041958042	POLD4/UNG/APEX1	-0.361332792810404
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	3/780	44/9376	0.81958041958042	ARHGDIA/ADCY3/AQP3	-0.361332792810404
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	5/780	72/9376	0.834757834757835	RNF125/ISG15/NFKBIB/CXCL8/TANK	-0.423971838693893
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	7/780	99/9376	0.84993524993525	C3/C1R/C1S/CFD/C2/MASP1/CFI	-0.45214449171041
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/780	15/9376	0.801367521367521	NTPCR	-0.231910015548669
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	13/780	178/9376	0.877902621722846	JUN/NKD2/TLE2/ROR2/WNT5B/DKK1/GPC4/LRP5/BAMBI/TP53/MYC/CSNK1E/PLCB3	-0.495398141944019
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	3/780	45/9376	0.801367521367521	ABCC3/TAP2/TAP1	-0.402325129995898
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	7/780	100/9376	0.841435897435898	CD55/CSF3R/CD59/ITGA1/CD1D/KITLG/IL1B	-0.480185719322082
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	5/780	73/9376	0.823322795925536	PPIA/MAP1A/RAN/FURIN/SERINC3	-0.456473083197431
NA	NA	hsa04081	Hormone signaling	16/780	219/9376	0.878210982320571	IGF2/INSR/NPR1/IRS2/GNG4/ADCY3/ADCY1/SLC40A1/GNB2/ADRA2A/GNAO1/PIK3R2/PLCB3/ADIPOR1/IRS1/GNG12	-0.549336320235962
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/780	16/9376	0.751282051282051	HEXB	-0.299925872100638
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	7/780	102/9376	0.824937154348919	PLA2G2A/ADCY3/ADCY1/SLC4A2/ATP2B3/ATP2B4/PLCB3	-0.535482472365549
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	2/780	32/9376	0.751282051282051	GALK1/HK2	-0.424522230737044
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	11/780	157/9376	0.842201535195166	ACTB/ID2/NKD2/ACTG1/ID1/WNT5B/SERPINE1/TEAD4/MYC/CSNK1E/PPP2R1A	-0.600613968755102
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/780	17/9376	0.707088989441931	GGT5	-0.364107957420185
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/780	17/9376	0.707088989441931	TXNRD2	-0.364107957420185
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/780	17/9376	0.707088989441931	GLUL	-0.364107957420185
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/780	17/9376	0.707088989441931	LAMP1	-0.364107957420185
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	7/780	104/9376	0.809072978303748	PLA2G2A/LPCAT4/GPD1L/LYPLA2/CHKB/LPCAT3/GNPAT	-0.589769205419148
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	5/780	77/9376	0.78055278055278	GADD45A/MAPK3/CDK4/TP53/PIK3R2	-0.582427747761604
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	4/780	63/9376	0.763207163207163	PLA2G2A/GGT5/PTGES/PTGES2	-0.568039805196457
NA	NA	hsa04082	Neuroactive ligand signaling	14/780	199/9376	0.84566421852854	GABRA2/GNG4/HTR2A/GABRE/GRIA3/ADCY3/ADCY1/P2RY1/GNB2/ADRA2A/GNAO1/PLCB3/GNG12/GRM7	-0.662868732436289
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	3/780	49/9376	0.735949764521193	GALNT13/B4GALT3/EOGT	-0.558210944130938
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	5/780	78/9376	0.770545693622617	INPP4B/TPI1/PLCD1/ALDH6A1/PLCB3	-0.612961898077949
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	6/780	93/9376	0.775516956162117	FOS/JUN/IFNGR2/MAF/MAPK3/NFKBIB	-0.655338341400429
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	4/780	66/9376	0.728515928515929	JUN/IFNGR2/MAF/IL1B	-0.666693494186155
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	2/780	36/9376	0.667806267806268	GALNT13/GCNT1	-0.601525416326668
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/780	20/9376	0.601025641025641	CYB5R1	-0.538021477789962
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	6/780	98/9376	0.735949764521193	CALM2/INPP4B/PLCD1/PIK3R2/PLCB3/CALM3	-0.791511353901289
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	9/780	143/9376	0.756535771920387	C3/C1R/C1S/C2/SNRPB/ACTN1/SNRPD1/CD40/ACTN4	-0.88372368927435
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/780	23/9376	0.52263099219621	B4GALT3	-0.690442325880624
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	8/780	133/9376	0.723038365143628	HLA-C/HLA-A/HLA-B/IFNGR2/MAPK3/SHC1/MAP2K2/PIK3R2	-0.96899981515269
NA	NA	hsa04382	Cornified envelope formation	14/780	217/9376	0.775516956162117	S100A6/S100A4/PLEC/S100A16/S100A3/S100A11/PKP2/CLDN10/UGCG/ABHD5/FURIN/PPL/PPP2R3B/PPP2R1A	-1.00779944769579
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/780	24/9376	0.500854700854701	NDST1	-0.737505211033027
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/780	26/9376	0.46232741617357	PLA2G2A	-0.826958083640225
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	12/780	195/9376	0.739723865877712	C3/ACTB/ACTG1/SLC25A6/MAPK3/GSDMD/MAP2K2/CASP4/CASP1/HDAC7/PIK3R2/PLCB3	-1.10634708435598
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	3/780	62/9376	0.581637717121588	TLE2/NCSTN/DTX4	-0.995554381897556
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	10/780	168/9376	0.715506715506716	PPIA/SLC25A6/IFNGR2/TNFRSF1A/HSP90AA1/PYGL/IL1B/CASP1/BCL2/GLUL	-1.12080159663976
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	3/780	63/9376	0.572405372405372	GADD45A/WNT5B/TP53	-1.02575218174527
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/780	28/9376	0.429304029304029	B4GALT3	-0.910980763173656
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/780	28/9376	0.429304029304029	TCIRG1	-0.910980763173656
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	8/780	142/9376	0.677211989888046	UBB/UBE2L6/UBE2N/ELOB/UBC/MID1/CBLB/UBA1	-1.16748515698335
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	3/780	65/9376	0.554792899408284	ALDH2/PNPLA2/ABHD16A	-1.08493903111544
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/780	30/9376	0.400683760683761	PLA2G2A	-0.990349577927733
Human Diseases	Substance dependence	hsa05034	Alcoholism	11/780	191/9376	0.692280843066183	FOSB/MAOB/GNG4/MAPK3/CALM2/SHC1/HDAC7/GNB2/GNAO1/CALM3/GNG12	-1.29424463491139
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/780	31/9376	0.387758478081059	ALDH2	-1.02848677141939
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	3/780	69/9376	0.52263099219621	MAPK3/MAP2K2/PIK3R2	-1.19883287660828
Organismal Systems	Sensory system	hsa04742	Taste transduction	4/780	86/9376	0.559093619558736	GABRA2/CACNA1C/P2RY1/PLCB3	-1.23729280765077
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	4/780	86/9376	0.559093619558736	CACNA1C/ADCY3/ADCY1/PLCB3	-1.23729280765077
NA	NA	hsa04519	Cadherin signaling	26/780	404/9376	0.773597359735974	ACTB/GJA1/GABRA2/VIM/ACTG1/CDH3/GABRE/DES/ACTN1/WNT5B/CDH13/MAPK3/ATN1/TEAD4/PKP2/LRP5/ARPC4/MAP2K2/NCSTN/ARPC1A/RRAS/AMOTL2/PCDHB10/WASF1/KDR/ACTN4	-1.4012391842956
Human Diseases	Immune disease	hsa05310	Asthma	1/780	32/9376	0.375641025641026	CD40	-1.06568209468526
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/780	33/9376	0.364257964257964	BCAT2	-1.10199458355673
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	5/780	110/9376	0.546386946386946	HSP90AA1/MAPK3/ADCY3/ADCY1/PIK3R2	-1.44151934364049
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	5/780	117/9376	0.513697129081744	ACTB/ACTG1/RUVBL2/MTA1/MBD3	-1.59441899044313
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	9/780	183/9376	0.591172761664565	FBL/NHP2/RAN/EMG1/IMP4/NOP58/IMP3/TBL3/AK6	-1.68236984010279
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/780	43/9376	0.279546809779368	PLA2G2A	-1.42631056717924
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	6/780	138/9376	0.52263099219621	MAPK3/ADCY3/ADCY1/CALM2/CALM3/PPP2R1A	-1.70172555319947
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2/780	66/9376	0.364257964257964	COMT/HSD17B7	-1.56121527459391
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	18/780	323/9376	0.669873779471303	VIM/PIM1/TNC/MCL1/IRS2/TIMP3/THBS1/TNXB/MAPK3/FOXP1/SHC1/TP53/MAP2K2/MYC/PIK3R2/BCL2/IRS1/PLAU	-1.81873639237358
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/780	44/9376	0.273193473193473	TAF10	-1.45560161238093
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	7/780	158/9376	0.532554365465758	GADD45A/CDC7/CDK4/CHEK2/TP53/MYC/PPP2R1A	-1.78494992117033
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/780	46/9376	0.261315496098105	CPOX	-1.51280105464687
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	2/780	79/9376	0.304316780266147	TCIRG1/SYT1	-1.87041679875894
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	2/780	83/9376	0.289650911337658	PCGF5/AUTS2	-1.95802233461169
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	16/780	370/9376	0.51980595980596	C3/GABRA2/TSPO/EDNRB/GAL/F2R/HTR2A/GABRE/NPW/PTGER3/F2RL2/GRIA3/PTGIR/P2RY1/ADRA2A/GRM7	-2.83881043186108
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	5/780	449/9376	0.133858717377648	SLC8A1/ADCY3/CALM2/CALM3/GRK2	-5.66557349902175