ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003735 structural constituent of ribosome 59/1273 175/18639 0.337142857142857 4.93637526652452 5.05199485332347e-26 5.84010605044193e-23 GO:0019843 rRNA binding 23/1273 65/18639 0.353846153846154 5.18094144661309 1.80026877420979e-11 1.04055535149326e-08 GO:0005201 extracellular matrix structural constituent 36/1273 168/18639 0.214285714285714 3.13752665245203 6.1298533154877e-10 2.36203681090126e-07 GO:0005518 collagen binding 22/1273 72/18639 0.305555555555556 4.47388059701493 1.25013671976189e-09 3.61289512011185e-07 GO:0044389 ubiquitin-like protein ligase binding 53/1273 322/18639 0.164596273291925 2.40998424028924 1.95896256273941e-09 4.52912144505351e-07 GO:0031625 ubiquitin protein ligase binding 49/1273 302/18639 0.162251655629139 2.37565483839083 1.28437987905368e-08 2.47457190031009e-06 GO:0045296 cadherin binding 52/1273 334/18639 0.155688622754491 2.27956028242023 1.93237098832711e-08 3.19117266072306e-06 GO:0005178 integrin binding 32/1273 161/18639 0.198757763975155 2.91016964865115 3.67814215599914e-08 5.31491541541875e-06 GO:0044183 protein folding chaperone 20/1273 75/18639 0.266666666666667 3.9044776119403 9.0246316956706e-08 1.15916380446613e-05 GO:0051082 unfolded protein binding 25/1273 121/18639 0.206611570247934 3.02516343900333 5.204713807521e-07 6.01664916149427e-05 GO:1901681 sulfur compound binding 42/1273 275/18639 0.152727272727273 2.23620081411126 7.46455044880603e-07 7.84456392619979e-05 GO:0019838 growth factor binding 26/1273 136/18639 0.191176470588235 2.79916593503073 1.48830398637786e-06 0.000143373284021068 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 17/1273 68/18639 0.25 3.66044776119403 2.20477011965645e-06 0.000196054942947912 GO:0009055 electron transfer activity 23/1273 116/18639 0.198275862068966 2.90311374163664 3.09384308602343e-06 0.000255463043388792 GO:0016860 intramolecular oxidoreductase activity 14/1273 53/18639 0.264150943396226 3.86764291748803 8.62727512689596e-06 0.000664875336446115 GO:0003746 translation elongation factor activity 8/1273 18/18639 0.444444444444444 6.50746268656716 1.09145655268162e-05 0.000788577359312472 GO:0033218 amide binding 36/1273 247/18639 0.145748987854251 2.13402622514956 1.31644438554218e-05 0.000895182182168684 GO:0043021 ribonucleoprotein complex binding 28/1273 177/18639 0.15819209039548 2.31621553250696 2.62389962390392e-05 0.00168512664735163 GO:0048029 monosaccharide binding 16/1273 74/18639 0.216216216216216 3.16579265832997 3.14320499030192e-05 0.00191239208883632 GO:0005539 glycosaminoglycan binding 34/1273 242/18639 0.140495867768595 2.05711113852226 4.8668503590988e-05 0.00281303950755911 GO:0008137 NADH dehydrogenase (ubiquinone) activity 11/1273 41/18639 0.268292682926829 3.92828540225701 6.77485790827194e-05 0.00362124564998327 GO:0061134 peptidase regulator activity 32/1273 226/18639 0.141592920353982 2.07317395324264 6.89164397055639e-05 0.00362124564998327 GO:0016504 peptidase activator activity 13/1273 57/18639 0.228070175438596 3.33935585231736 9.56812393962572e-05 0.00480902229313362 GO:0001968 fibronectin binding 9/1273 30/18639 0.3 4.39253731343284 0.00012105013441702 0.00567626261108483 GO:0044325 transmembrane transporter binding 22/1273 136/18639 0.161764705882353 2.36852502194908 0.0001326349411404 0.00567626261108483 GO:0043394 proteoglycan binding 10/1273 37/18639 0.27027027027027 3.95724082291246 0.000135269495992541 0.00567626261108483 GO:0003954 NADH dehydrogenase activity 11/1273 44/18639 0.25 3.66044776119403 0.000136081760078804 0.00567626261108483 GO:0022853 active monoatomic ion transmembrane transporter activity 20/1273 118/18639 0.169491525423729 2.4816594991146 0.000137487329680255 0.00567626261108483 GO:0003779 actin binding 51/1273 443/18639 0.115124153498871 1.68562379973721 0.000174767037206191 0.0069665756900123 GO:0008191 metalloendopeptidase inhibitor activity 6/1273 14/18639 0.428571428571429 6.27505330490405 0.000186867423120736 0.00720062470425237 GO:0015026 coreceptor activity 13/1273 61/18639 0.213114754098361 3.12038169806704 0.000198842781739273 0.00741491147389031 GO:0140662 ATP-dependent protein folding chaperone 10/1273 40/18639 0.25 3.66044776119403 0.000272849081080742 0.00969328239113728 GO:0001094 TFIID-class transcription factor complex binding 5/1273 10/18639 0.5 7.32089552238806 0.000277922265164451 0.00969328239113728 GO:0031386 protein tag activity 6/1273 15/18639 0.4 5.85671641791045 0.000293481733295679 0.00969328239113728 GO:0141047 molecular tag activity 6/1273 15/18639 0.4 5.85671641791045 0.000293481733295679 0.00969328239113728 GO:0015399 primary active transmembrane transporter activity 24/1273 166/18639 0.144578313253012 2.11688545225679 0.000389470628421043 0.0125063346237424 GO:0042277 peptide binding 32/1273 249/18639 0.1285140562249 1.88167595756159 0.000418398778722533 0.013072134816304 GO:0004857 enzyme inhibitor activity 47/1273 416/18639 0.112980769230769 1.65424081515499 0.000470275019568991 0.0135584277891653 GO:0070990 snRNP binding 5/1273 11/18639 0.454545454545455 6.65535956580733 0.000480878494252404 0.0135584277891653 GO:0097493 structural molecule activity conferring elasticity 5/1273 11/18639 0.454545454545455 6.65535956580733 0.000480878494252404 0.0135584277891653 GO:1990948 ubiquitin ligase inhibitor activity 5/1273 11/18639 0.454545454545455 6.65535956580733 0.000480878494252404 0.0135584277891653 GO:0050840 extracellular matrix binding 13/1273 67/18639 0.194029850746269 2.84094453107596 0.000524557592732489 0.013832299833359 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 9/1273 36/18639 0.25 3.66044776119403 0.00054923451103832 0.013832299833359 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 9/1273 36/18639 0.25 3.66044776119403 0.00054923451103832 0.013832299833359 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 9/1273 36/18639 0.25 3.66044776119403 0.00054923451103832 0.013832299833359 GO:0016853 isomerase activity 25/1273 180/18639 0.138888888888889 2.03358208955224 0.000550420235583489 0.013832299833359 GO:0005200 structural constituent of cytoskeleton 18/1273 112/18639 0.160714285714286 2.35314498933902 0.000566880172513635 0.0139428399877822 GO:0051787 misfolded protein binding 6/1273 17/18639 0.352941176470588 5.16769095697981 0.00064456291568822 0.0153806515233577 GO:0008201 heparin binding 24/1273 172/18639 0.13953488372093 2.04304061089899 0.000657548332324392 0.0153806515233577 GO:0016209 antioxidant activity 15/1273 86/18639 0.174418604651163 2.55380076362374 0.000665253093570836 0.0153806515233577 GO:0097371 MDM2/MDM4 family protein binding 5/1273 12/18639 0.416666666666667 6.10074626865672 0.000778100199723703 0.0176369378604039 GO:0001091 RNA polymerase II general transcription initiation factor binding 7/1273 24/18639 0.291666666666667 4.2705223880597 0.000840623414322124 0.0186877051337765 GO:0002020 protease binding 20/1273 136/18639 0.147058823529412 2.15320456540825 0.000926060330771854 0.0201840839747314 GO:0140297 DNA-binding transcription factor binding 52/1273 488/18639 0.10655737704918 1.56019084903352 0.000951088370370507 0.0201840839747314 GO:0048306 calcium-dependent protein binding 14/1273 80/18639 0.175 2.56231343283582 0.000960315414022687 0.0201840839747314 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 9/1273 39/18639 0.230769230769231 3.3788748564868 0.00102733172282545 0.0212070619926111 GO:0001618 virus receptor activity 14/1273 81/18639 0.172839506172839 2.53067993366501 0.00108938777363091 0.0219113027335124 GO:0120020 cholesterol transfer activity 7/1273 25/18639 0.28 4.09970149253731 0.00109935601950149 0.0219113027335124 GO:0140272 exogenous protein binding 14/1273 82/18639 0.170731707317073 2.49981798325446 0.00123270526050661 0.024013493023594 GO:0015036 disulfide oxidoreductase activity 9/1273 40/18639 0.225 3.29440298507463 0.00124637507042875 0.024013493023594 GO:0140416 transcription regulator inhibitor activity 8/1273 33/18639 0.242424242424242 3.54952510176391 0.00137989078217504 0.0261500613802351 GO:0042287 MHC protein binding 9/1273 41/18639 0.219512195121951 3.21405169275573 0.00150157134648548 0.0279783361437847 GO:0043022 ribosome binding 17/1273 112/18639 0.151785714285714 2.22241471215352 0.00152889549671091 0.0279783361437847 GO:0004175 endopeptidase activity 44/1273 405/18639 0.108641975308642 1.59071310116086 0.00154897362733756 0.0279783361437847 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 11/1273 58/18639 0.189655172413793 2.77689140504375 0.00167724204239477 0.0293405833355357 GO:0042288 MHC class I protein binding 6/1273 20/18639 0.3 4.39253731343284 0.00169088382217314 0.0293405833355357 GO:0061135 endopeptidase regulator activity 24/1273 184/18639 0.130434782608696 1.90979883192732 0.00170053553934333 0.0293405833355357 GO:0016859 cis-trans isomerase activity 9/1273 42/18639 0.214285714285714 3.13752665245203 0.0017970844877093 0.0305504362910581 GO:0032934 sterol binding 12/1273 68/18639 0.176470588235294 2.5838454784899 0.00201032049557009 0.0336801520707105 GO:0001221 transcription coregulator binding 17/1273 115/18639 0.147826086956522 2.1644386761843 0.00204717913003453 0.0338077010617131 GO:0055105 ubiquitin-protein transferase inhibitor activity 5/1273 15/18639 0.333333333333333 4.88059701492537 0.0024825644403617 0.0404203449726497 GO:0030021 extracellular matrix structural constituent conferring compression resistance 6/1273 22/18639 0.272727272727273 3.9932157394844 0.00289357662701487 0.0464579802892942 GO:0015485 cholesterol binding 10/1273 54/18639 0.185185185185185 2.71144278606965 0.00322587137826712 0.0495457417545539 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 10/1273 54/18639 0.185185185185185 2.71144278606965 0.00322587137826712 0.0495457417545539 GO:0003714 transcription corepressor activity 25/1273 204/18639 0.122549019607843 1.79433713784021 0.00325118936756573 0.0495457417545539 GO:0043121 neurotrophin binding 4/1273 10/18639 0.4 5.85671641791045 0.00325733250289455 0.0495457417545539 GO:0004602 glutathione peroxidase activity 6/1273 23/18639 0.260869565217391 3.81959766385464 0.00369163413575888 0.0547119110376572 GO:0005158 insulin receptor binding 6/1273 23/18639 0.260869565217391 3.81959766385464 0.00369163413575888 0.0547119110376572 GO:0038024 cargo receptor activity 11/1273 65/18639 0.169230769230769 2.47784156142365 0.00426142901272281 0.0623383680584762 GO:0019955 cytokine binding 19/1273 144/18639 0.131944444444444 1.93190298507463 0.0043140739140814 0.0623383680584762 GO:0005536 D-glucose binding 4/1273 11/18639 0.363636363636364 5.32428765264586 0.00484387765069005 0.0682868605389964 GO:0010854 adenylate cyclase regulator activity 4/1273 11/18639 0.363636363636364 5.32428765264586 0.00484387765069005 0.0682868605389964 GO:0030515 snoRNA binding 7/1273 32/18639 0.21875 3.20289179104478 0.0050624054309587 0.0696683414070031 GO:0120015 sterol transfer activity 7/1273 32/18639 0.21875 3.20289179104478 0.0050624054309587 0.0696683414070031 GO:0098631 cell adhesion mediator activity 12/1273 76/18639 0.157894736842105 2.31186174391202 0.00518701885324934 0.070543456404191 GO:1901611 phosphatidylglycerol binding 5/1273 18/18639 0.277777777777778 4.06716417910448 0.00596619556040575 0.0801967682305703 GO:0071889 14-3-3 protein binding 7/1273 33/18639 0.212121212121212 3.10583446404342 0.00605385168255431 0.0804396844256642 GO:0051879 Hsp90 protein binding 8/1273 42/18639 0.19047619047619 2.78891257995736 0.00679893125885469 0.0893132333549548 GO:0043548 phosphatidylinositol 3-kinase binding 6/1273 26/18639 0.230769230769231 3.3788748564868 0.00706390724077485 0.0917514243857947 GO:0003756 protein disulfide isomerase activity 5/1273 19/18639 0.263157894736842 3.85310290652003 0.00764857811078639 0.0957532392773626 GO:0005520 insulin-like growth factor binding 5/1273 19/18639 0.263157894736842 3.85310290652003 0.00764857811078639 0.0957532392773626 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 5/1273 19/18639 0.263157894736842 3.85310290652003 0.00764857811078639 0.0957532392773626 GO:0019207 kinase regulator activity 31/1273 287/18639 0.10801393728223 1.58151749960996 0.00770333153355945 0.0957532392773626 GO:0015078 proton transmembrane transporter activity 22/1273 185/18639 0.118918918918919 1.74118596208148 0.00784856296656971 0.0960731275689553 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 10/1273 61/18639 0.163934426229508 2.40029361389772 0.0078952829749574 0.0960731275689553 GO:0004364 glutathione transferase activity 6/1273 27/18639 0.222222222222222 3.25373134328358 0.00856757992135238 0.103167941552952 GO:0140296 general transcription initiation factor binding 9/1273 53/18639 0.169811320754717 2.48634187552802 0.00911395095422357 0.108615745392603 GO:0031994 insulin-like growth factor I binding 4/1273 13/18639 0.307692307692308 4.50516647531573 0.00940262543359432 0.109823123843878 GO:0008238 exopeptidase activity 14/1273 102/18639 0.137254901960784 2.00965759438104 0.00940526752642205 0.109823123843878 GO:0043178 alcohol binding 13/1273 92/18639 0.141304347826087 2.06894873458793 0.00953796520807247 0.110258877805318 GO:0030246 carbohydrate binding 30/1273 280/18639 0.107142857142857 1.56876332622601 0.00964807063609915 0.110427422330006 GO:0055106 ubiquitin-protein transferase regulator activity 7/1273 36/18639 0.194444444444444 2.84701492537313 0.00989861920601012 0.112184351001448 GO:0042605 peptide antigen binding 8/1273 45/18639 0.177777777777778 2.60298507462687 0.0103651246500156 0.11522298031314 GO:0001540 amyloid-beta binding 12/1273 83/18639 0.144578313253012 2.11688545225679 0.0104657551322489 0.11522298031314 GO:0008135 translation factor activity, RNA binding 12/1273 83/18639 0.144578313253012 2.11688545225679 0.0104657551322489 0.11522298031314 GO:0051117 ATPase binding 12/1273 84/18639 0.142857142857143 2.09168443496802 0.0114739231337173 0.12396126301474 GO:0180051 translation factor activity 12/1273 84/18639 0.142857142857143 2.09168443496802 0.0114739231337173 0.12396126301474 GO:0051861 glycolipid binding 6/1273 29/18639 0.206896551724138 3.02933607822954 0.0122384972411948 0.130969834718984 GO:0032036 myosin heavy chain binding 4/1273 14/18639 0.285714285714286 4.18336886993603 0.0124625275251629 0.130969834718984 GO:0098847 sequence-specific single stranded DNA binding 4/1273 14/18639 0.285714285714286 4.18336886993603 0.0124625275251629 0.130969834718984 GO:0008236 serine-type peptidase activity 22/1273 194/18639 0.11340206185567 1.6604092937375 0.0133052039492385 0.138565907795673 GO:1990782 protein tyrosine kinase binding 15/1273 117/18639 0.128205128205128 1.87715269804822 0.0134544157409975 0.13886879104101 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 16/1273 128/18639 0.125 1.83022388059702 0.0137383208560642 0.140544238138143 GO:0004866 endopeptidase inhibitor activity 19/1273 161/18639 0.118012422360248 1.72791322888662 0.0138641285573919 0.140587128178466 GO:0035925 mRNA 3'-UTR AU-rich region binding 6/1273 30/18639 0.2 2.92835820895522 0.0144355981878088 0.144350945485586 GO:0004601 peroxidase activity 9/1273 57/18639 0.157894736842105 2.31186174391202 0.0145129553208996 0.144350945485586 GO:0061133 endopeptidase activator activity 5/1273 22/18639 0.227272727272727 3.32767978290366 0.0146107979521627 0.144350945485586 GO:0008083 growth factor activity 19/1273 162/18639 0.117283950617284 1.71724709784411 0.0147347850928193 0.144350945485586 GO:0005496 steroid binding 14/1273 108/18639 0.12962962962963 1.89800995024876 0.0151645723346852 0.147312988394085 GO:0019887 protein kinase regulator activity 27/1273 255/18639 0.105882352941176 1.55030728709394 0.0156260844269054 0.150462810637401 GO:0004129 cytochrome-c oxidase activity 4/1273 15/18639 0.266666666666667 3.9044776119403 0.0160916050105451 0.150462810637401 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 4/1273 15/18639 0.266666666666667 3.9044776119403 0.0160916050105451 0.150462810637401 GO:0051015 actin filament binding 23/1273 209/18639 0.110047846889952 1.6112975790902 0.0161101487110264 0.150462810637401 GO:0004197 cysteine-type endopeptidase activity 12/1273 88/18639 0.136363636363636 1.9966078697422 0.0162697675862242 0.150462810637401 GO:0016651 oxidoreductase activity, acting on NAD(P)H 12/1273 88/18639 0.136363636363636 1.9966078697422 0.0162697675862242 0.150462810637401 GO:0017171 serine hydrolase activity 22/1273 198/18639 0.111111111111111 1.62686567164179 0.0165428977192328 0.151774521932009 GO:0031072 heat shock protein binding 16/1273 131/18639 0.122137404580153 1.78831035661388 0.0168541106272999 0.152561392180069 GO:0070325 lipoprotein particle receptor binding 6/1273 31/18639 0.193548387096774 2.83389504092441 0.0168926108988312 0.152561392180069 GO:0004252 serine-type endopeptidase activity 20/1273 176/18639 0.113636363636364 1.66383989145183 0.0173028047718224 0.155054591598657 GO:0004177 aminopeptidase activity 7/1273 40/18639 0.175 2.56231343283582 0.0174526291118925 0.155194148102674 GO:0099186 structural constituent of postsynapse 5/1273 23/18639 0.217391304347826 3.1829980532122 0.0176438990122748 0.155697307314425 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 9/1273 59/18639 0.152542372881356 2.23349354920314 0.0179600408284022 0.157286418163886 GO:0033293 monocarboxylic acid binding 11/1273 79/18639 0.139240506329114 2.03873039863971 0.0180989837842545 0.157311468079686 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 15/1273 122/18639 0.122950819672131 1.80022021042329 0.0191523402867339 0.165224666951227 GO:0097110 scaffold protein binding 10/1273 70/18639 0.142857142857143 2.09168443496802 0.0200210513554552 0.16947638725248 GO:0000062 fatty-acyl-CoA binding 4/1273 16/18639 0.25 3.66044776119403 0.0203188547795802 0.16947638725248 GO:0005159 insulin-like growth factor receptor binding 4/1273 16/18639 0.25 3.66044776119403 0.0203188547795802 0.16947638725248 GO:0016675 oxidoreductase activity, acting on a heme group of donors 4/1273 16/18639 0.25 3.66044776119403 0.0203188547795802 0.16947638725248 GO:0051087 protein-folding chaperone binding 16/1273 134/18639 0.119402985074627 1.74827355758521 0.0204877533540348 0.16947638725248 GO:0022804 active transmembrane transporter activity 43/1273 457/18639 0.0940919037199125 1.37767399327215 0.0205248219855945 0.16947638725248 GO:0016247 channel regulator activity 19/1273 168/18639 0.113095238095238 1.65591684434968 0.0208946240510747 0.170291402859244 GO:0048027 mRNA 5'-UTR binding 5/1273 24/18639 0.208333333333333 3.05037313432836 0.0210654590042144 0.170291402859244 GO:0050431 transforming growth factor beta binding 5/1273 24/18639 0.208333333333333 3.05037313432836 0.0210654590042144 0.170291402859244 GO:0030414 peptidase inhibitor activity 19/1273 169/18639 0.112426035502959 1.6461185198269 0.022089648087991 0.177330786039706 GO:0042056 chemoattractant activity 7/1273 42/18639 0.166666666666667 2.44029850746269 0.0224508397648338 0.178987384607916 GO:0141108 transporter regulator activity 19/1273 170/18639 0.111764705882353 1.63643546971027 0.0233363187999399 0.184772496799524 GO:0005080 protein kinase C binding 8/1273 52/18639 0.153846153846154 2.25258323765786 0.0238044218765674 0.187196678158585 GO:0004029 aldehyde dehydrogenase (NAD+) activity 4/1273 17/18639 0.235294117647059 3.4451273046532 0.0251670990097066 0.192669976524642 GO:0016018 cyclosporin A binding 4/1273 17/18639 0.235294117647059 3.4451273046532 0.0251670990097066 0.192669976524642 GO:0030169 low-density lipoprotein particle binding 4/1273 17/18639 0.235294117647059 3.4451273046532 0.0251670990097066 0.192669976524642 GO:1901567 fatty acid derivative binding 4/1273 17/18639 0.235294117647059 3.4451273046532 0.0251670990097066 0.192669976524642 GO:0015035 protein-disulfide reductase activity 6/1273 34/18639 0.176470588235294 2.5838454784899 0.0259496874916917 0.195338790729345 GO:0042562 hormone binding 12/1273 94/18639 0.127659574468085 1.86916481422674 0.0261064252320398 0.195338790729345 GO:0042826 histone deacetylase binding 15/1273 127/18639 0.118110236220472 1.72934539898931 0.0265222813436333 0.195338790729345 GO:0008239 dipeptidyl-peptidase activity 3/1273 10/18639 0.3 4.39253731343284 0.0265295762495737 0.195338790729345 GO:0047429 nucleoside triphosphate diphosphatase activity 3/1273 10/18639 0.3 4.39253731343284 0.0265295762495737 0.195338790729345 GO:0097177 mitochondrial ribosome binding 3/1273 10/18639 0.3 4.39253731343284 0.0265295762495737 0.195338790729345 GO:0031490 chromatin DNA binding 15/1273 128/18639 0.1171875 1.7158348880597 0.0282192672490627 0.20618138354611 GO:0001046 core promoter sequence-specific DNA binding 7/1273 44/18639 0.159090909090909 2.32937584803256 0.0283588581175013 0.20618138354611 GO:0050750 low-density lipoprotein particle receptor binding 5/1273 26/18639 0.192307692307692 2.81572904707233 0.0291363517231012 0.207911250567315 GO:0070006 metalloaminopeptidase activity 5/1273 26/18639 0.192307692307692 2.81572904707233 0.0291363517231012 0.207911250567315 GO:0070412 R-SMAD binding 5/1273 26/18639 0.192307692307692 2.81572904707233 0.0291363517231012 0.207911250567315 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 4/1273 18/18639 0.222222222222222 3.25373134328358 0.0306530714237926 0.216066771743319 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 4/1273 18/18639 0.222222222222222 3.25373134328358 0.0306530714237926 0.216066771743319 GO:0031406 carboxylic acid binding 20/1273 187/18639 0.106951871657754 1.56596695666055 0.0308861154522041 0.216389996743927 GO:0120013 lipid transfer activity 9/1273 65/18639 0.138461538461538 2.02732491389208 0.0318297149136246 0.221657532771988 GO:0005044 scavenger receptor activity 5/1273 27/18639 0.185185185185185 2.71144278606965 0.033811072587135 0.230281267167375 GO:0043177 organic acid binding 20/1273 189/18639 0.105820105820106 1.54939587775409 0.0340373041702002 0.230281267167375 GO:0008503 benzodiazepine receptor activity 3/1273 11/18639 0.272727272727273 3.9932157394844 0.0346617132241551 0.230281267167375 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 3/1273 11/18639 0.272727272727273 3.9932157394844 0.0346617132241551 0.230281267167375 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 3/1273 11/18639 0.272727272727273 3.9932157394844 0.0346617132241551 0.230281267167375 GO:0034511 U3 snoRNA binding 3/1273 11/18639 0.272727272727273 3.9932157394844 0.0346617132241551 0.230281267167375 GO:0034713 type I transforming growth factor beta receptor binding 3/1273 11/18639 0.272727272727273 3.9932157394844 0.0346617132241551 0.230281267167375 GO:0050998 nitric-oxide synthase binding 3/1273 11/18639 0.272727272727273 3.9932157394844 0.0346617132241551 0.230281267167375 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 7/1273 46/18639 0.152173913043478 2.22809863724854 0.0352376700877415 0.232018032230724 GO:0005319 lipid transporter activity 19/1273 178/18639 0.106741573033708 1.56288780815026 0.0353245446994874 0.232018032230724 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 15/1273 132/18639 0.113636363636364 1.66383989145183 0.0358150697245245 0.233910850856217 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 33/1273 349/18639 0.0945558739255014 1.38446734807339 0.03633152150046 0.234952867612488 GO:0003697 single-stranded DNA binding 14/1273 121/18639 0.115702479338843 1.69409152584187 0.0364949817742019 0.234952867612488 GO:0070003 threonine-type peptidase activity 4/1273 19/18639 0.210526315789474 3.08248232521602 0.0367876029739276 0.234952867612488 GO:0120227 acyl-CoA binding 4/1273 19/18639 0.210526315789474 3.08248232521602 0.0367876029739276 0.234952867612488 GO:0042805 actinin binding 6/1273 37/18639 0.162162162162162 2.37434449374748 0.0377591119206694 0.239832600990626 GO:0051393 alpha-actinin binding 5/1273 28/18639 0.178571428571429 2.61460554371002 0.038924920791605 0.244550045842909 GO:0097718 disordered domain specific binding 5/1273 28/18639 0.178571428571429 2.61460554371002 0.038924920791605 0.244550045842909 GO:0051020 GTPase binding 30/1273 315/18639 0.0952380952380952 1.39445628997868 0.0408851832624148 0.254780179632026 GO:1990841 promoter-specific chromatin binding 9/1273 68/18639 0.132352941176471 1.93788410886743 0.0409940427435613 0.254780179632026 GO:0000287 magnesium ion binding 23/1273 230/18639 0.1 1.46417910447761 0.0426651065997461 0.263747931707521 GO:0010851 cyclase regulator activity 4/1273 20/18639 0.2 2.92835820895522 0.0435758846656618 0.26583982551071 GO:0008179 adenylate cyclase binding 3/1273 12/18639 0.25 3.66044776119403 0.0439233621734823 0.26583982551071 GO:0031543 peptidyl-proline dioxygenase activity 3/1273 12/18639 0.25 3.66044776119403 0.0439233621734823 0.26583982551071 GO:0070008 serine-type exopeptidase activity 3/1273 12/18639 0.25 3.66044776119403 0.0439233621734823 0.26583982551071 GO:0005516 calmodulin binding 21/1273 207/18639 0.101449275362319 1.48539909149903 0.0448769660265619 0.270196732951591 GO:0072341 modified amino acid binding 11/1273 91/18639 0.120879120879121 1.76988682958832 0.0454949894418365 0.271900710503863 GO:0019209 kinase activator activity 16/1273 148/18639 0.108108108108108 1.58289632916499 0.0457049144805704 0.271900710503863 GO:0001786 phosphatidylserine binding 8/1273 59/18639 0.135593220338983 1.98532759929168 0.046317139440002 0.271900710503863 GO:0070888 E-box binding 8/1273 59/18639 0.135593220338983 1.98532759929168 0.046317139440002 0.271900710503863 GO:0099106 ion channel regulator activity 17/1273 160/18639 0.10625 1.55569029850746 0.0463360207346548 0.271900710503863 GO:0016763 pentosyltransferase activity 7/1273 49/18639 0.142857142857143 2.09168443496802 0.0474838202119394 0.277228768510111 GO:0004714 transmembrane receptor protein tyrosine kinase activity 8/1273 60/18639 0.133333333333333 1.95223880597015 0.050382744825941 0.291857581135807 GO:0098918 structural constituent of synapse 5/1273 30/18639 0.166666666666667 2.44029850746269 0.0504943911999667 0.291857581135807 GO:0008373 sialyltransferase activity 4/1273 21/18639 0.19047619047619 2.78891257995736 0.0510177885621616 0.293415739193327 GO:0005006 epidermal growth factor receptor activity 7/1273 50/18639 0.14 2.04985074626866 0.0520988662967485 0.297671714319656 GO:0030295 protein kinase activator activity 15/1273 139/18639 0.107913669064748 1.58004939332116 0.0524874218739498 0.297671714319656 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 6/1273 40/18639 0.15 2.19626865671642 0.0525303025269981 0.297671714319656 GO:0005035 death receptor activity 3/1273 13/18639 0.230769230769231 3.3788748564868 0.0542795831954488 0.304598049388053 GO:0005172 vascular endothelial growth factor receptor binding 3/1273 13/18639 0.230769230769231 3.3788748564868 0.0542795831954488 0.304598049388053 GO:0005126 cytokine receptor binding 26/1273 275/18639 0.0945454545454545 1.38431478968792 0.0578731367254985 0.323194908476697 GO:0140517 protein-RNA adaptor activity 4/1273 22/18639 0.181818181818182 2.66214382632293 0.059108230919939 0.328505360305046 GO:0004860 protein kinase inhibitor activity 10/1273 84/18639 0.119047619047619 1.74307036247335 0.0597271917624276 0.329929199529312 GO:0043539 protein serine/threonine kinase activator activity 9/1273 73/18639 0.123287671232877 1.80515232058884 0.059935235208612 0.329929199529312 GO:0005507 copper ion binding 8/1273 63/18639 0.126984126984127 1.8592750533049 0.0639305800981801 0.349423733703284 GO:0008307 structural constituent of muscle 6/1273 42/18639 0.142857142857143 2.09168443496802 0.0640811691566577 0.349423733703284 GO:0008474 palmitoyl-(protein) hydrolase activity 3/1273 14/18639 0.214285714285714 3.13752665245203 0.0656842347418905 0.353167327263374 GO:0098599 palmitoyl hydrolase activity 3/1273 14/18639 0.214285714285714 3.13752665245203 0.0656842347418905 0.353167327263374 GO:1901612 cardiolipin binding 3/1273 14/18639 0.214285714285714 3.13752665245203 0.0656842347418905 0.353167327263374 GO:0005003 ephrin receptor activity 7/1273 53/18639 0.132075471698113 1.93382145874402 0.0675850769809847 0.358083214291416 GO:0005005 transmembrane-ephrin receptor activity 7/1273 53/18639 0.132075471698113 1.93382145874402 0.0675850769809847 0.358083214291416 GO:0017134 fibroblast growth factor binding 4/1273 23/18639 0.173913043478261 2.54639844256976 0.0678375639531315 0.358083214291416 GO:0031681 G-protein beta-subunit binding 4/1273 23/18639 0.173913043478261 2.54639844256976 0.0678375639531315 0.358083214291416 GO:0048156 tau protein binding 6/1273 43/18639 0.13953488372093 2.04304061089899 0.0703721019432039 0.369773408392472 GO:0051287 NAD binding 7/1273 54/18639 0.12962962962963 1.89800995024876 0.0732989768039452 0.383410032512944 GO:0016790 thiolester hydrolase activity 6/1273 44/18639 0.136363636363636 1.9966078697422 0.0770057720209464 0.397635442088036 GO:0000774 adenyl-nucleotide exchange factor activity 3/1273 15/18639 0.2 2.92835820895522 0.0780823921747267 0.397635442088036 GO:0005041 low-density lipoprotein particle receptor activity 3/1273 15/18639 0.2 2.92835820895522 0.0780823921747267 0.397635442088036 GO:0005523 tropomyosin binding 3/1273 15/18639 0.2 2.92835820895522 0.0780823921747267 0.397635442088036 GO:0050700 CARD domain binding 3/1273 15/18639 0.2 2.92835820895522 0.0780823921747267 0.397635442088036 GO:0051371 muscle alpha-actinin binding 3/1273 15/18639 0.2 2.92835820895522 0.0780823921747267 0.397635442088036 GO:0019199 transmembrane receptor protein kinase activity 9/1273 78/18639 0.115384615384615 1.6894374282434 0.0837158116133338 0.424453851864096 GO:0016922 nuclear receptor binding 14/1273 137/18639 0.102189781021898 1.49624142063406 0.0849635191291652 0.428898812721899 GO:0019210 kinase inhibitor activity 10/1273 90/18639 0.111111111111111 1.62686567164179 0.0864193512120052 0.434351173917731 GO:0019211 phosphatase activator activity 4/1273 25/18639 0.16 2.34268656716418 0.0871539533394483 0.436147056538538 GO:0008142 oxysterol binding 3/1273 16/18639 0.1875 2.74533582089552 0.0914124392659144 0.451593076031611 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 3/1273 16/18639 0.1875 2.74533582089552 0.0914124392659144 0.451593076031611 GO:0031435 mitogen-activated protein kinase kinase kinase binding 3/1273 16/18639 0.1875 2.74533582089552 0.0914124392659144 0.451593076031611 GO:0070851 growth factor receptor binding 14/1273 139/18639 0.100719424460432 1.47471276709975 0.0930122553454631 0.457541136933427 GO:0002039 p53 binding 8/1273 69/18639 0.115942028985507 1.69759896171317 0.0972245014961519 0.472569937467256 GO:0005160 transforming growth factor beta receptor binding 4/1273 26/18639 0.153846153846154 2.25258323765786 0.0977026081787839 0.472569937467256 GO:0050681 nuclear androgen receptor binding 4/1273 26/18639 0.153846153846154 2.25258323765786 0.0977026081787839 0.472569937467256 GO:0120014 phospholipid transfer activity 4/1273 26/18639 0.153846153846154 2.25258323765786 0.0977026081787839 0.472569937467256 GO:0001784 phosphotyrosine residue binding 6/1273 47/18639 0.127659574468085 1.86916481422674 0.0989353030493065 0.474561038692939 GO:0005504 fatty acid binding 6/1273 47/18639 0.127659574468085 1.86916481422674 0.0989353030493065 0.474561038692939 GO:0030971 receptor tyrosine kinase binding 9/1273 81/18639 0.111111111111111 1.62686567164179 0.100353033527973 0.479372341976598 GO:0019208 phosphatase regulator activity 12/1273 117/18639 0.102564102564103 1.50172215843858 0.102887109142374 0.486017309713298 GO:0023023 MHC protein complex binding 5/1273 37/18639 0.135135135135135 1.97862041145623 0.105054265236829 0.486017309713298 GO:0004659 prenyltransferase activity 3/1273 17/18639 0.176470588235294 2.5838454784899 0.105607869320816 0.486017309713298 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 3/1273 17/18639 0.176470588235294 2.5838454784899 0.105607869320816 0.486017309713298 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 3/1273 17/18639 0.176470588235294 2.5838454784899 0.105607869320816 0.486017309713298 GO:0019198 transmembrane receptor protein phosphatase activity 3/1273 17/18639 0.176470588235294 2.5838454784899 0.105607869320816 0.486017309713298 GO:0045236 CXCR chemokine receptor binding 3/1273 17/18639 0.176470588235294 2.5838454784899 0.105607869320816 0.486017309713298 GO:0048038 quinone binding 3/1273 17/18639 0.176470588235294 2.5838454784899 0.105607869320816 0.486017309713298 GO:0070492 oligosaccharide binding 3/1273 17/18639 0.176470588235294 2.5838454784899 0.105607869320816 0.486017309713298 GO:0016879 ligase activity, forming carbon-nitrogen bonds 6/1273 48/18639 0.125 1.83022388059702 0.106906357602431 0.486017309713298 GO:0016798 hydrolase activity, acting on glycosyl bonds 13/1273 130/18639 0.1 1.46417910447761 0.107069696441008 0.486017309713298 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 4/1273 27/18639 0.148148148148148 2.16915422885572 0.108814179586027 0.486017309713298 GO:0023026 MHC class II protein complex binding 4/1273 27/18639 0.148148148148148 2.16915422885572 0.108814179586027 0.486017309713298 GO:0001098 basal transcription machinery binding 7/1273 60/18639 0.116666666666667 1.70820895522388 0.113328190280781 0.486017309713298 GO:0001099 basal RNA polymerase II transcription machinery binding 7/1273 60/18639 0.116666666666667 1.70820895522388 0.113328190280781 0.486017309713298 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 7/1273 60/18639 0.116666666666667 1.70820895522388 0.113328190280781 0.486017309713298 GO:0019888 protein phosphatase regulator activity 11/1273 107/18639 0.102803738317757 1.50523085507044 0.113475927924144 0.486017309713298 GO:0005501 retinoid binding 5/1273 38/18639 0.131578947368421 1.92655145326002 0.114555477126576 0.486017309713298 GO:0019840 isoprenoid binding 5/1273 38/18639 0.131578947368421 1.92655145326002 0.114555477126576 0.486017309713298 GO:0019903 protein phosphatase binding 14/1273 144/18639 0.0972222222222222 1.42350746268657 0.115139527614205 0.486017309713298 GO:0001222 transcription corepressor binding 6/1273 49/18639 0.122448979591837 1.79287237282973 0.115197874447616 0.486017309713298 GO:0005004 GPI-linked ephrin receptor activity 6/1273 49/18639 0.122448979591837 1.79287237282973 0.115197874447616 0.486017309713298 GO:0005008 hepatocyte growth factor receptor activity 6/1273 49/18639 0.122448979591837 1.79287237282973 0.115197874447616 0.486017309713298 GO:0005009 insulin receptor activity 6/1273 49/18639 0.122448979591837 1.79287237282973 0.115197874447616 0.486017309713298 GO:0005011 macrophage colony-stimulating factor receptor activity 6/1273 49/18639 0.122448979591837 1.79287237282973 0.115197874447616 0.486017309713298 GO:0005018 platelet-derived growth factor alpha-receptor activity 6/1273 49/18639 0.122448979591837 1.79287237282973 0.115197874447616 0.486017309713298 GO:0005020 stem cell factor receptor activity 6/1273 49/18639 0.122448979591837 1.79287237282973 0.115197874447616 0.486017309713298 GO:0008288 boss receptor activity 6/1273 49/18639 0.122448979591837 1.79287237282973 0.115197874447616 0.486017309713298 GO:0036332 placental growth factor receptor activity 6/1273 49/18639 0.122448979591837 1.79287237282973 0.115197874447616 0.486017309713298 GO:0038062 protein tyrosine kinase collagen receptor activity 6/1273 49/18639 0.122448979591837 1.79287237282973 0.115197874447616 0.486017309713298 GO:0060175 brain-derived neurotrophic factor receptor activity 6/1273 49/18639 0.122448979591837 1.79287237282973 0.115197874447616 0.486017309713298 GO:0060590 ATPase regulator activity 6/1273 49/18639 0.122448979591837 1.79287237282973 0.115197874447616 0.486017309713298 GO:0046625 sphingolipid binding 4/1273 28/18639 0.142857142857143 2.09168443496802 0.120462389385098 0.499685470281918 GO:0051019 mitogen-activated protein kinase binding 4/1273 28/18639 0.142857142857143 2.09168443496802 0.120462389385098 0.499685470281918 GO:0015172 acidic amino acid transmembrane transporter activity 3/1273 18/18639 0.166666666666667 2.44029850746269 0.120598828900221 0.499685470281918 GO:0030228 lipoprotein particle receptor activity 3/1273 18/18639 0.166666666666667 2.44029850746269 0.120598828900221 0.499685470281918 GO:0031690 adrenergic receptor binding 3/1273 18/18639 0.166666666666667 2.44029850746269 0.120598828900221 0.499685470281918 GO:0005007 fibroblast growth factor receptor activity 6/1273 50/18639 0.12 1.75701492537313 0.123802284650007 0.507501564026269 GO:0005017 platelet-derived growth factor receptor activity 6/1273 50/18639 0.12 1.75701492537313 0.123802284650007 0.507501564026269 GO:0005019 platelet-derived growth factor beta-receptor activity 6/1273 50/18639 0.12 1.75701492537313 0.123802284650007 0.507501564026269 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 5/1273 39/18639 0.128205128205128 1.87715269804822 0.124450598540083 0.508356508524155 GO:0008237 metallopeptidase activity 17/1273 184/18639 0.0923913043478261 1.35277417261518 0.125967454370254 0.512740764971881 GO:0004222 metalloendopeptidase activity 11/1273 110/18639 0.1 1.46417910447761 0.130544172653094 0.529013954925538 GO:0050660 flavin adenine dinucleotide binding 9/1273 86/18639 0.104651162790698 1.53228045817425 0.131958771248429 0.529013954925538 GO:0043236 laminin binding 4/1273 29/18639 0.137931034482759 2.01955738548636 0.132618836908376 0.529013954925538 GO:0005010 insulin-like growth factor receptor activity 6/1273 51/18639 0.117647058823529 1.7225636523266 0.132711113259867 0.529013954925538 GO:0005021 vascular endothelial growth factor receptor activity 6/1273 51/18639 0.117647058823529 1.7225636523266 0.132711113259867 0.529013954925538 GO:0005030 neurotrophin receptor activity 6/1273 51/18639 0.117647058823529 1.7225636523266 0.132711113259867 0.529013954925538 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 5/1273 40/18639 0.125 1.83022388059702 0.134724926541952 0.534163828570099 GO:0046982 protein heterodimerization activity 31/1273 369/18639 0.0840108401084011 1.23006916636331 0.135695245550206 0.534163828570099 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 3/1273 19/18639 0.157894736842105 2.31186174391202 0.136313433761401 0.534163828570099 GO:0050145 nucleoside monophosphate kinase activity 3/1273 19/18639 0.157894736842105 2.31186174391202 0.136313433761401 0.534163828570099 GO:0097001 ceramide binding 3/1273 19/18639 0.157894736842105 2.31186174391202 0.136313433761401 0.534163828570099 GO:0019003 GDP binding 8/1273 75/18639 0.106666666666667 1.56179104477612 0.138642768582514 0.534776635835459 GO:0008081 phosphoric diester hydrolase activity 9/1273 87/18639 0.103448275862069 1.51466803911477 0.138842497160269 0.534776635835459 GO:0001217 DNA-binding transcription repressor activity 24/1273 278/18639 0.0863309352517986 1.26403951465693 0.140573031052684 0.534776635835459 GO:0001530 lipopolysaccharide binding 5/1273 41/18639 0.121951219512195 1.78558427375319 0.145362558111176 0.534776635835459 GO:0017080 sodium channel regulator activity 5/1273 41/18639 0.121951219512195 1.78558427375319 0.145362558111176 0.534776635835459 GO:0140318 protein transporter activity 5/1273 41/18639 0.121951219512195 1.78558427375319 0.145362558111176 0.534776635835459 GO:0004955 prostaglandin receptor activity 2/1273 10/18639 0.2 2.92835820895522 0.145722007169697 0.534776635835459 GO:0005031 tumor necrosis factor receptor activity 2/1273 10/18639 0.2 2.92835820895522 0.145722007169697 0.534776635835459 GO:0005381 iron ion transmembrane transporter activity 2/1273 10/18639 0.2 2.92835820895522 0.145722007169697 0.534776635835459 GO:0005528 FK506 binding 2/1273 10/18639 0.2 2.92835820895522 0.145722007169697 0.534776635835459 GO:0031996 thioesterase binding 2/1273 10/18639 0.2 2.92835820895522 0.145722007169697 0.534776635835459 GO:0035256 G protein-coupled glutamate receptor binding 2/1273 10/18639 0.2 2.92835820895522 0.145722007169697 0.534776635835459 GO:0043295 glutathione binding 2/1273 10/18639 0.2 2.92835820895522 0.145722007169697 0.534776635835459 GO:0043422 protein kinase B binding 2/1273 10/18639 0.2 2.92835820895522 0.145722007169697 0.534776635835459 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 2/1273 10/18639 0.2 2.92835820895522 0.145722007169697 0.534776635835459 GO:0070513 death domain binding 2/1273 10/18639 0.2 2.92835820895522 0.145722007169697 0.534776635835459 GO:0098505 G-rich strand telomeric DNA binding 2/1273 10/18639 0.2 2.92835820895522 0.145722007169697 0.534776635835459 GO:0140940 histone H2A methyltransferase activity 2/1273 10/18639 0.2 2.92835820895522 0.145722007169697 0.534776635835459 GO:1905394 retromer complex binding 2/1273 10/18639 0.2 2.92835820895522 0.145722007169697 0.534776635835459 GO:1990259 histone H2AQ104 methyltransferase activity 2/1273 10/18639 0.2 2.92835820895522 0.145722007169697 0.534776635835459 GO:0038064 collagen receptor activity 6/1273 53/18639 0.113207547169811 1.65756125035201 0.151403973673598 0.546417213599239 GO:0003712 transcription coregulator activity 40/1273 495/18639 0.0808080808080808 1.1831750339213 0.152054737036081 0.546417213599239 GO:0001972 retinoic acid binding 3/1273 20/18639 0.15 2.19626865671642 0.152678883601825 0.546417213599239 GO:0016408 C-acyltransferase activity 3/1273 20/18639 0.15 2.19626865671642 0.152678883601825 0.546417213599239 GO:0016505 peptidase activator activity involved in apoptotic process 3/1273 20/18639 0.15 2.19626865671642 0.152678883601825 0.546417213599239 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 3/1273 20/18639 0.15 2.19626865671642 0.152678883601825 0.546417213599239 GO:0031418 L-ascorbic acid binding 3/1273 20/18639 0.15 2.19626865671642 0.152678883601825 0.546417213599239 GO:0043024 ribosomal small subunit binding 3/1273 20/18639 0.15 2.19626865671642 0.152678883601825 0.546417213599239 GO:0003727 single-stranded RNA binding 9/1273 89/18639 0.101123595505618 1.48063055508972 0.153148077167953 0.546417213599239 GO:0019902 phosphatase binding 17/1273 190/18639 0.0894736842105263 1.31005498821681 0.153960554510634 0.547625849274748 GO:0016411 acylglycerol O-acyltransferase activity 4/1273 31/18639 0.129032258064516 1.88926336061627 0.15833441812703 0.551763130788915 GO:0031267 small GTPase binding 24/1273 283/18639 0.0848056537102474 1.24170666104108 0.160408544954384 0.551763130788915 GO:0004713 protein tyrosine kinase activity 13/1273 140/18639 0.0928571428571429 1.35959488272921 0.16050228355908 0.551763130788915 GO:0050661 NADP binding 6/1273 54/18639 0.111111111111111 1.62686567164179 0.161167098282305 0.551763130788915 GO:0017124 SH3 domain binding 11/1273 115/18639 0.0956521739130435 1.40051914341337 0.161889774330975 0.551763130788915 GO:0005525 GTP binding 31/1273 378/18639 0.082010582010582 1.20078180525942 0.166579561229258 0.551763130788915 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 3/1273 21/18639 0.142857142857143 2.09168443496802 0.169622399441769 0.551763130788915 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 3/1273 21/18639 0.142857142857143 2.09168443496802 0.169622399441769 0.551763130788915 GO:0009975 cyclase activity 3/1273 21/18639 0.142857142857143 2.09168443496802 0.169622399441769 0.551763130788915 GO:0035613 RNA stem-loop binding 3/1273 21/18639 0.142857142857143 2.09168443496802 0.169622399441769 0.551763130788915 GO:0036122 BMP binding 3/1273 21/18639 0.142857142857143 2.09168443496802 0.169622399441769 0.551763130788915 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 3/1273 21/18639 0.142857142857143 2.09168443496802 0.169622399441769 0.551763130788915 GO:0072542 protein phosphatase activator activity 3/1273 21/18639 0.142857142857143 2.09168443496802 0.169622399441769 0.551763130788915 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 2/1273 11/18639 0.181818181818182 2.66214382632293 0.170402072490928 0.551763130788915 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 2/1273 11/18639 0.181818181818182 2.66214382632293 0.170402072490928 0.551763130788915 GO:0004016 adenylate cyclase activity 2/1273 11/18639 0.181818181818182 2.66214382632293 0.170402072490928 0.551763130788915 GO:0004954 prostanoid receptor activity 2/1273 11/18639 0.181818181818182 2.66214382632293 0.170402072490928 0.551763130788915 GO:0005114 type II transforming growth factor beta receptor binding 2/1273 11/18639 0.181818181818182 2.66214382632293 0.170402072490928 0.551763130788915 GO:0008526 phosphatidylinositol transfer activity 2/1273 11/18639 0.181818181818182 2.66214382632293 0.170402072490928 0.551763130788915 GO:0015217 ADP transmembrane transporter activity 2/1273 11/18639 0.181818181818182 2.66214382632293 0.170402072490928 0.551763130788915 GO:0019215 intermediate filament binding 2/1273 11/18639 0.181818181818182 2.66214382632293 0.170402072490928 0.551763130788915 GO:0032050 clathrin heavy chain binding 2/1273 11/18639 0.181818181818182 2.66214382632293 0.170402072490928 0.551763130788915 GO:0032794 GTPase activating protein binding 2/1273 11/18639 0.181818181818182 2.66214382632293 0.170402072490928 0.551763130788915 GO:0042608 T cell receptor binding 2/1273 11/18639 0.181818181818182 2.66214382632293 0.170402072490928 0.551763130788915 GO:0048185 activin binding 2/1273 11/18639 0.181818181818182 2.66214382632293 0.170402072490928 0.551763130788915 GO:0048407 platelet-derived growth factor binding 2/1273 11/18639 0.181818181818182 2.66214382632293 0.170402072490928 0.551763130788915 GO:0070697 activin receptor binding 2/1273 11/18639 0.181818181818182 2.66214382632293 0.170402072490928 0.551763130788915 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 2/1273 11/18639 0.181818181818182 2.66214382632293 0.170402072490928 0.551763130788915 GO:1900750 oligopeptide binding 2/1273 11/18639 0.181818181818182 2.66214382632293 0.170402072490928 0.551763130788915 GO:0046332 SMAD binding 8/1273 79/18639 0.10126582278481 1.48271301719252 0.170435275526267 0.551763130788915 GO:0098632 cell-cell adhesion mediator activity 6/1273 55/18639 0.109090909090909 1.59728629579376 0.171192959347102 0.551763130788915 GO:0016500 protein-hormone receptor activity 7/1273 67/18639 0.104477611940299 1.52973936288706 0.171683105049988 0.551763130788915 GO:0070717 poly-purine tract binding 4/1273 32/18639 0.125 1.83022388059702 0.171829348688589 0.551763130788915 GO:0071813 lipoprotein particle binding 4/1273 32/18639 0.125 1.83022388059702 0.171829348688589 0.551763130788915 GO:0071814 protein-lipid complex binding 4/1273 32/18639 0.125 1.83022388059702 0.171829348688589 0.551763130788915 GO:0052689 carboxylic ester hydrolase activity 9/1273 92/18639 0.0978260869565217 1.43234912394549 0.175892940911199 0.56324720136661 GO:0005125 cytokine activity 20/1273 234/18639 0.0854700854700855 1.25143513203215 0.177565608914424 0.564711219752872 GO:0001223 transcription coactivator binding 5/1273 44/18639 0.113636363636364 1.66383989145183 0.179281157136076 0.564711219752872 GO:0016248 channel inhibitor activity 5/1273 44/18639 0.113636363636364 1.66383989145183 0.179281157136076 0.564711219752872 GO:0019205 nucleobase-containing compound kinase activity 5/1273 44/18639 0.113636363636364 1.66383989145183 0.179281157136076 0.564711219752872 GO:0030020 extracellular matrix structural constituent conferring tensile strength 5/1273 44/18639 0.113636363636364 1.66383989145183 0.179281157136076 0.564711219752872 GO:0030547 signaling receptor inhibitor activity 5/1273 44/18639 0.113636363636364 1.66383989145183 0.179281157136076 0.564711219752872 GO:0005548 phospholipid transporter activity 7/1273 68/18639 0.102941176470588 1.50724319578578 0.180930260355721 0.568357013508731 GO:0051219 phosphoprotein binding 9/1273 93/18639 0.0967741935483871 1.41694752046221 0.183799951727651 0.575806894843265 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 4/1273 33/18639 0.121212121212121 1.77476255088195 0.18570474114275 0.580201839894645 GO:0008009 chemokine activity 5/1273 45/18639 0.111111111111111 1.62686567164179 0.191193805683332 0.581559572300531 GO:0141110 transporter inhibitor activity 5/1273 45/18639 0.111111111111111 1.62686567164179 0.191193805683332 0.581559572300531 GO:0003995 acyl-CoA dehydrogenase activity 2/1273 12/18639 0.166666666666667 2.44029850746269 0.195697814554417 0.581559572300531 GO:0004300 enoyl-CoA hydratase activity 2/1273 12/18639 0.166666666666667 2.44029850746269 0.195697814554417 0.581559572300531 GO:0005049 nuclear export signal receptor activity 2/1273 12/18639 0.166666666666667 2.44029850746269 0.195697814554417 0.581559572300531 GO:0005078 MAP-kinase scaffold activity 2/1273 12/18639 0.166666666666667 2.44029850746269 0.195697814554417 0.581559572300531 GO:0005165 neurotrophin receptor binding 2/1273 12/18639 0.166666666666667 2.44029850746269 0.195697814554417 0.581559572300531 GO:0005527 macrolide binding 2/1273 12/18639 0.166666666666667 2.44029850746269 0.195697814554417 0.581559572300531 GO:0010853 cyclase activator activity 2/1273 12/18639 0.166666666666667 2.44029850746269 0.195697814554417 0.581559572300531 GO:0016208 AMP binding 2/1273 12/18639 0.166666666666667 2.44029850746269 0.195697814554417 0.581559572300531 GO:0016801 hydrolase activity, acting on ether bonds 2/1273 12/18639 0.166666666666667 2.44029850746269 0.195697814554417 0.581559572300531 GO:0016803 ether hydrolase activity 2/1273 12/18639 0.166666666666667 2.44029850746269 0.195697814554417 0.581559572300531 GO:0016840 carbon-nitrogen lyase activity 2/1273 12/18639 0.166666666666667 2.44029850746269 0.195697814554417 0.581559572300531 GO:0036009 protein-glutamine N-methyltransferase activity 2/1273 12/18639 0.166666666666667 2.44029850746269 0.195697814554417 0.581559572300531 GO:0043047 single-stranded telomeric DNA binding 2/1273 12/18639 0.166666666666667 2.44029850746269 0.195697814554417 0.581559572300531 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 2/1273 12/18639 0.166666666666667 2.44029850746269 0.195697814554417 0.581559572300531 GO:0070410 co-SMAD binding 2/1273 12/18639 0.166666666666667 2.44029850746269 0.195697814554417 0.581559572300531 GO:0097677 STAT family protein binding 2/1273 12/18639 0.166666666666667 2.44029850746269 0.195697814554417 0.581559572300531 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 2/1273 12/18639 0.166666666666667 2.44029850746269 0.195697814554417 0.581559572300531 GO:0030291 protein serine/threonine kinase inhibitor activity 5/1273 46/18639 0.108695652173913 1.5914990266061 0.203377036430255 0.599824024948521 GO:0004022 alcohol dehydrogenase (NAD+) activity 3/1273 23/18639 0.130434782608696 1.90979883192732 0.204957171154555 0.599824024948521 GO:0005212 structural constituent of eye lens 3/1273 23/18639 0.130434782608696 1.90979883192732 0.204957171154555 0.599824024948521 GO:0016849 phosphorus-oxygen lyase activity 3/1273 23/18639 0.130434782608696 1.90979883192732 0.204957171154555 0.599824024948521 GO:0042171 lysophosphatidic acid acyltransferase activity 3/1273 23/18639 0.130434782608696 1.90979883192732 0.204957171154555 0.599824024948521 GO:0071617 lysophospholipid acyltransferase activity 3/1273 23/18639 0.130434782608696 1.90979883192732 0.204957171154555 0.599824024948521 GO:0004896 cytokine receptor activity 9/1273 96/18639 0.09375 1.37266791044776 0.208427247986758 0.606355535146763 GO:0008234 cysteine-type peptidase activity 16/1273 187/18639 0.0855614973262032 1.25277356532844 0.208715548532191 0.606355535146763 GO:0016757 glycosyltransferase activity 22/1273 267/18639 0.0823970037453183 1.20643971155459 0.208762545837726 0.606355535146763 GO:0004879 nuclear receptor activity 6/1273 59/18639 0.101694915254237 1.48899569946876 0.213675749871908 0.615892232492679 GO:0015459 potassium channel regulator activity 6/1273 59/18639 0.101694915254237 1.48899569946876 0.213675749871908 0.615892232492679 GO:0045309 protein phosphorylated amino acid binding 6/1273 59/18639 0.101694915254237 1.48899569946876 0.213675749871908 0.615892232492679 GO:0005154 epidermal growth factor receptor binding 4/1273 35/18639 0.114285714285714 1.67334754797441 0.214461023663108 0.615892232492679 GO:0140597 protein carrier chaperone 16/1273 188/18639 0.0851063829787234 1.24610987615116 0.214709835375908 0.615892232492679 GO:0004721 phosphoprotein phosphatase activity 15/1273 175/18639 0.0857142857142857 1.25501066098081 0.216118473776339 0.618398405162 GO:0140789 histone phosphatase activity 12/1273 136/18639 0.0882352941176471 1.29192273924495 0.218798555910747 0.622663512479964 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 2/1273 13/18639 0.153846153846154 2.25258323765786 0.221410220256048 0.622663512479964 GO:0019104 DNA N-glycosylase activity 2/1273 13/18639 0.153846153846154 2.25258323765786 0.221410220256048 0.622663512479964 GO:0031432 titin binding 2/1273 13/18639 0.153846153846154 2.25258323765786 0.221410220256048 0.622663512479964 GO:0043560 insulin receptor substrate binding 2/1273 13/18639 0.153846153846154 2.25258323765786 0.221410220256048 0.622663512479964 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 2/1273 13/18639 0.153846153846154 2.25258323765786 0.221410220256048 0.622663512479964 GO:0140410 monoatomic cation:bicarbonate symporter activity 2/1273 13/18639 0.153846153846154 2.25258323765786 0.221410220256048 0.622663512479964 GO:0004622 lysophospholipase activity 3/1273 24/18639 0.125 1.83022388059702 0.223209340613361 0.622663512479964 GO:0035035 histone acetyltransferase binding 3/1273 24/18639 0.125 1.83022388059702 0.223209340613361 0.622663512479964 GO:0070300 phosphatidic acid binding 3/1273 24/18639 0.125 1.83022388059702 0.223209340613361 0.622663512479964 GO:0001664 G protein-coupled receptor binding 24/1273 297/18639 0.0808080808080808 1.1831750339213 0.223534046435281 0.622663512479964 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 6/1273 60/18639 0.1 1.46417910447761 0.224825478715367 0.623257202386005 GO:0098531 ligand-modulated transcription factor activity 6/1273 60/18639 0.1 1.46417910447761 0.224825478715367 0.623257202386005 GO:0140693 molecular condensate scaffold activity 5/1273 48/18639 0.104166666666667 1.52518656716418 0.228473857341257 0.631855930828931 GO:0001848 complement binding 3/1273 25/18639 0.12 1.75701492537313 0.241762347968895 0.653649842342228 GO:0003707 nuclear steroid receptor activity 3/1273 25/18639 0.12 1.75701492537313 0.241762347968895 0.653649842342228 GO:0005251 delayed rectifier potassium channel activity 3/1273 25/18639 0.12 1.75701492537313 0.241762347968895 0.653649842342228 GO:0005537 D-mannose binding 3/1273 25/18639 0.12 1.75701492537313 0.241762347968895 0.653649842342228 GO:0015296 monoatomic anion:monoatomic cation symporter activity 3/1273 25/18639 0.12 1.75701492537313 0.241762347968895 0.653649842342228 GO:0015662 P-type ion transporter activity 3/1273 25/18639 0.12 1.75701492537313 0.241762347968895 0.653649842342228 GO:0042974 nuclear retinoic acid receptor binding 3/1273 25/18639 0.12 1.75701492537313 0.241762347968895 0.653649842342228 GO:0047617 fatty acyl-CoA hydrolase activity 3/1273 25/18639 0.12 1.75701492537313 0.241762347968895 0.653649842342228 GO:0140358 P-type transmembrane transporter activity 3/1273 25/18639 0.12 1.75701492537313 0.241762347968895 0.653649842342228 GO:0005347 ATP transmembrane transporter activity 2/1273 14/18639 0.142857142857143 2.09168443496802 0.247364551175074 0.653649842342228 GO:0019992 diacylglycerol binding 2/1273 14/18639 0.142857142857143 2.09168443496802 0.247364551175074 0.653649842342228 GO:0031404 chloride ion binding 2/1273 14/18639 0.142857142857143 2.09168443496802 0.247364551175074 0.653649842342228 GO:0042043 neurexin family protein binding 2/1273 14/18639 0.142857142857143 2.09168443496802 0.247364551175074 0.653649842342228 GO:0043176 amine binding 2/1273 14/18639 0.142857142857143 2.09168443496802 0.247364551175074 0.653649842342228 GO:0044548 S100 protein binding 2/1273 14/18639 0.142857142857143 2.09168443496802 0.247364551175074 0.653649842342228 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 2/1273 14/18639 0.142857142857143 2.09168443496802 0.247364551175074 0.653649842342228 GO:0071933 Arp2/3 complex binding 2/1273 14/18639 0.142857142857143 2.09168443496802 0.247364551175074 0.653649842342228 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 2/1273 14/18639 0.142857142857143 2.09168443496802 0.247364551175074 0.653649842342228 GO:1901474 azole transmembrane transporter activity 2/1273 14/18639 0.142857142857143 2.09168443496802 0.247364551175074 0.653649842342228 GO:0015179 L-amino acid transmembrane transporter activity 6/1273 62/18639 0.0967741935483871 1.41694752046221 0.247663175558733 0.653649842342228 GO:0032813 tumor necrosis factor receptor superfamily binding 5/1273 50/18639 0.1 1.46417910447761 0.254406555177361 0.665326651347919 GO:0019001 guanyl nucleotide binding 31/1273 400/18639 0.0775 1.13473880597015 0.256627108777403 0.665326651347919 GO:0032561 guanyl ribonucleotide binding 31/1273 400/18639 0.0775 1.13473880597015 0.256627108777403 0.665326651347919 GO:0140104 molecular carrier activity 20/1273 249/18639 0.0803212851405622 1.17604747347599 0.257154966403937 0.665326651347919 GO:0042162 telomeric DNA binding 4/1273 38/18639 0.105263157894737 1.54124116260801 0.259598151210607 0.665326651347919 GO:0043531 ADP binding 4/1273 38/18639 0.105263157894737 1.54124116260801 0.259598151210607 0.665326651347919 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 37/1273 484/18639 0.0764462809917355 1.11931047243123 0.259838377842177 0.665326651347919 GO:0035401 histone H3Y41 kinase activity 10/1273 115/18639 0.0869565217391304 1.27319922128488 0.25992701225113 0.665326651347919 GO:0140801 histone H2AXY142 kinase activity 10/1273 115/18639 0.0869565217391304 1.27319922128488 0.25992701225113 0.665326651347919 GO:0004112 cyclic-nucleotide phosphodiesterase activity 3/1273 26/18639 0.115384615384615 1.6894374282434 0.260552748811083 0.665326651347919 GO:0004435 phosphatidylinositol phospholipase C activity 3/1273 26/18639 0.115384615384615 1.6894374282434 0.260552748811083 0.665326651347919 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 3/1273 26/18639 0.115384615384615 1.6894374282434 0.260552748811083 0.665326651347919 GO:0008143 poly(A) binding 3/1273 26/18639 0.115384615384615 1.6894374282434 0.260552748811083 0.665326651347919 GO:0016289 acyl-CoA hydrolase activity 3/1273 26/18639 0.115384615384615 1.6894374282434 0.260552748811083 0.665326651347919 GO:0017022 myosin binding 7/1273 76/18639 0.0921052631578947 1.34858601728201 0.26143357868725 0.665326651347919 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 8/1273 89/18639 0.0898876404494382 1.31611604896864 0.261871649103204 0.665326651347919 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 8/1273 89/18639 0.0898876404494382 1.31611604896864 0.261871649103204 0.665326651347919 GO:0004722 protein serine/threonine phosphatase activity 9/1273 103/18639 0.087378640776699 1.27937980002898 0.270444329614877 0.68116293545554 GO:0140793 histone H2AXY142 phosphatase activity 8/1273 90/18639 0.0888888888888889 1.30149253731343 0.271755480230156 0.68116293545554 GO:0004953 icosanoid receptor activity 2/1273 15/18639 0.133333333333333 1.95223880597015 0.273407960252051 0.68116293545554 GO:0008242 omega peptidase activity 2/1273 15/18639 0.133333333333333 1.95223880597015 0.273407960252051 0.68116293545554 GO:0015556 C4-dicarboxylate transmembrane transporter activity 2/1273 15/18639 0.133333333333333 1.95223880597015 0.273407960252051 0.68116293545554 GO:0031005 filamin binding 2/1273 15/18639 0.133333333333333 1.95223880597015 0.273407960252051 0.68116293545554 GO:0042809 nuclear vitamin D receptor binding 2/1273 15/18639 0.133333333333333 1.95223880597015 0.273407960252051 0.68116293545554 GO:0140161 monocarboxylate:sodium symporter activity 2/1273 15/18639 0.133333333333333 1.95223880597015 0.273407960252051 0.68116293545554 GO:0140776 protein-containing complex destabilizing activity 2/1273 15/18639 0.133333333333333 1.95223880597015 0.273407960252051 0.68116293545554 GO:0016776 phosphotransferase activity, phosphate group as acceptor 4/1273 39/18639 0.102564102564103 1.50172215843858 0.275043585801524 0.683764269218412 GO:0008266 poly(U) RNA binding 3/1273 27/18639 0.111111111111111 1.62686567164179 0.279520069964215 0.691916918369662 GO:0008320 protein transmembrane transporter activity 3/1273 27/18639 0.111111111111111 1.62686567164179 0.279520069964215 0.691916918369662 GO:0030159 signaling receptor complex adaptor activity 5/1273 52/18639 0.0961538461538462 1.40786452353617 0.281008711946859 0.694115536347371 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 8/1273 91/18639 0.0879120879120879 1.28719042151878 0.281741984453642 0.694442929698104 GO:0160215 deacylase activity 6/1273 65/18639 0.0923076923076923 1.35154994259472 0.283051336574274 0.696185840595447 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 21/1273 268/18639 0.0783582089552239 1.14730452216529 0.287775344615492 0.706302119693224 GO:0001216 DNA-binding transcription activator activity 37/1273 491/18639 0.0753564154786151 1.10335288932121 0.289374337415072 0.707801354548514 GO:0071949 FAD binding 4/1273 40/18639 0.1 1.46417910447761 0.290634547941476 0.707801354548514 GO:0016829 lyase activity 16/1273 200/18639 0.08 1.17134328358209 0.291988289841923 0.707801354548514 GO:0008514 organic anion transmembrane transporter activity 21/1273 269/18639 0.0780669144981413 1.14303944959219 0.293616291769818 0.707801354548514 GO:0008146 sulfotransferase activity 5/1273 53/18639 0.0943396226415094 1.38130104196001 0.294509205516991 0.707801354548514 GO:0017046 peptide hormone binding 5/1273 53/18639 0.0943396226415094 1.38130104196001 0.294509205516991 0.707801354548514 GO:0034212 protein N-acetyltransferase activity 5/1273 53/18639 0.0943396226415094 1.38130104196001 0.294509205516991 0.707801354548514 GO:0051018 protein kinase A binding 5/1273 53/18639 0.0943396226415094 1.38130104196001 0.294509205516991 0.707801354548514 GO:0008235 metalloexopeptidase activity 6/1273 66/18639 0.0909090909090909 1.33107191316147 0.295091653491148 0.707801354548514 GO:0050698 proteoglycan sulfotransferase activity 3/1273 28/18639 0.107142857142857 1.56876332622601 0.298606991633709 0.707801354548514 GO:0005149 interleukin-1 receptor binding 2/1273 16/18639 0.125 1.83022388059702 0.299407320392927 0.707801354548514 GO:0015385 sodium:proton antiporter activity 2/1273 16/18639 0.125 1.83022388059702 0.299407320392927 0.707801354548514 GO:0016722 oxidoreductase activity, acting on metal ions 2/1273 16/18639 0.125 1.83022388059702 0.299407320392927 0.707801354548514 GO:0017070 U6 snRNA binding 2/1273 16/18639 0.125 1.83022388059702 0.299407320392927 0.707801354548514 GO:0019841 retinol binding 2/1273 16/18639 0.125 1.83022388059702 0.299407320392927 0.707801354548514 GO:0022858 alanine transmembrane transporter activity 2/1273 16/18639 0.125 1.83022388059702 0.299407320392927 0.707801354548514 GO:0070411 I-SMAD binding 2/1273 16/18639 0.125 1.83022388059702 0.299407320392927 0.707801354548514 GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 2/1273 16/18639 0.125 1.83022388059702 0.299407320392927 0.707801354548514 GO:0003823 antigen binding 14/1273 174/18639 0.0804597701149425 1.17807514153371 0.301417767421435 0.709962634160785 GO:0051213 dioxygenase activity 8/1273 93/18639 0.0860215053763441 1.25950890707752 0.301989706356646 0.709962634160785 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 18/1273 229/18639 0.0786026200873362 1.1508831388907 0.302164027687808 0.709962634160785 GO:0140828 metal cation:monoatomic cation antiporter activity 4/1273 41/18639 0.0975609756097561 1.42846741900255 0.306339627923131 0.718107999387793 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 6/1273 67/18639 0.0895522388059701 1.31120516818891 0.307230199239458 0.718107999387793 GO:0003925 G protein activity 5/1273 54/18639 0.0925925925925926 1.35572139303483 0.308115542989918 0.718107999387793 GO:0017069 snRNA binding 5/1273 54/18639 0.0925925925925926 1.35572139303483 0.308115542989918 0.718107999387793 GO:0033192 calmodulin-dependent protein phosphatase activity 7/1273 81/18639 0.0864197530864197 1.2653399668325 0.316101005332854 0.725025321755514 GO:0140791 histone H2AXS140 phosphatase activity 7/1273 81/18639 0.0864197530864197 1.2653399668325 0.316101005332854 0.725025321755514 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 7/1273 81/18639 0.0864197530864197 1.2653399668325 0.316101005332854 0.725025321755514 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 7/1273 81/18639 0.0864197530864197 1.2653399668325 0.316101005332854 0.725025321755514 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 7/1273 81/18639 0.0864197530864197 1.2653399668325 0.316101005332854 0.725025321755514 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 7/1273 81/18639 0.0864197530864197 1.2653399668325 0.316101005332854 0.725025321755514 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 7/1273 81/18639 0.0864197530864197 1.2653399668325 0.316101005332854 0.725025321755514 GO:1990439 MAP kinase serine/threonine phosphatase activity 7/1273 81/18639 0.0864197530864197 1.2653399668325 0.316101005332854 0.725025321755514 GO:0004629 phospholipase C activity 3/1273 29/18639 0.103448275862069 1.51466803911477 0.317759471025094 0.725948514832032 GO:0005416 amino acid:monoatomic cation symporter activity 3/1273 29/18639 0.103448275862069 1.51466803911477 0.317759471025094 0.725948514832032 GO:0008374 O-acyltransferase activity 5/1273 55/18639 0.0909090909090909 1.33107191316147 0.3218078013542 0.728617893905712 GO:0140313 molecular sequestering activity 5/1273 55/18639 0.0909090909090909 1.33107191316147 0.3218078013542 0.728617893905712 GO:0004520 DNA endonuclease activity 4/1273 42/18639 0.0952380952380952 1.39445628997868 0.322128375115932 0.728617893905712 GO:0048487 beta-tubulin binding 4/1273 42/18639 0.0952380952380952 1.39445628997868 0.322128375115932 0.728617893905712 GO:0005092 GDP-dissociation inhibitor activity 2/1273 17/18639 0.117647058823529 1.7225636523266 0.325247247202542 0.728617893905712 GO:0008484 sulfuric ester hydrolase activity 2/1273 17/18639 0.117647058823529 1.7225636523266 0.325247247202542 0.728617893905712 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 2/1273 17/18639 0.117647058823529 1.7225636523266 0.325247247202542 0.728617893905712 GO:0030548 acetylcholine receptor regulator activity 2/1273 17/18639 0.117647058823529 1.7225636523266 0.325247247202542 0.728617893905712 GO:0032977 membrane insertase activity 2/1273 17/18639 0.117647058823529 1.7225636523266 0.325247247202542 0.728617893905712 GO:0046965 nuclear retinoid X receptor binding 2/1273 17/18639 0.117647058823529 1.7225636523266 0.325247247202542 0.728617893905712 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 7/1273 82/18639 0.0853658536585366 1.24990899162723 0.327288104469801 0.728617893905712 GO:0033549 MAP kinase phosphatase activity 7/1273 82/18639 0.0853658536585366 1.24990899162723 0.327288104469801 0.728617893905712 GO:0004620 phospholipase activity 9/1273 109/18639 0.0825688073394495 1.2089552238806 0.327362598513835 0.728617893905712 GO:0019842 vitamin binding 12/1273 150/18639 0.08 1.17134328358209 0.327751993798417 0.728617893905712 GO:0003924 GTPase activity 25/1273 331/18639 0.0755287009063444 1.10587545655409 0.329477661259137 0.731048323254437 GO:0016407 acetyltransferase activity 8/1273 96/18639 0.0833333333333333 1.22014925373134 0.332922517059043 0.737276685287841 GO:0008187 poly-pyrimidine tract binding 3/1273 30/18639 0.1 1.46417910447761 0.336926815914841 0.741186331486605 GO:0015215 nucleotide transmembrane transporter activity 3/1273 30/18639 0.1 1.46417910447761 0.336926815914841 0.741186331486605 GO:0016769 transferase activity, transferring nitrogenous groups 3/1273 30/18639 0.1 1.46417910447761 0.336926815914841 0.741186331486605 GO:0008200 ion channel inhibitor activity 4/1273 43/18639 0.0930232558139535 1.36202707393266 0.337971392637352 0.741186331486605 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 7/1273 83/18639 0.0843373493975904 1.23484984714979 0.338534933412567 0.741186331486605 GO:0030165 PDZ domain binding 7/1273 83/18639 0.0843373493975904 1.23484984714979 0.338534933412567 0.741186331486605 GO:0016782 transferase activity, transferring sulphur-containing groups 6/1273 70/18639 0.0857142857142857 1.25501066098081 0.344094022774459 0.751032433723748 GO:0004527 exonuclease activity 7/1273 84/18639 0.0833333333333333 1.22014925373134 0.349831021918891 0.751032433723748 GO:0017018 myosin phosphatase activity 7/1273 84/18639 0.0833333333333333 1.22014925373134 0.349831021918891 0.751032433723748 GO:0004706 JUN kinase kinase kinase activity 2/1273 18/18639 0.111111111111111 1.62686567164179 0.350828299490332 0.751032433723748 GO:0008525 phosphatidylcholine transporter activity 2/1273 18/18639 0.111111111111111 1.62686567164179 0.350828299490332 0.751032433723748 GO:0017128 phospholipid scramblase activity 2/1273 18/18639 0.111111111111111 1.62686567164179 0.350828299490332 0.751032433723748 GO:0022851 GABA-gated chloride ion channel activity 2/1273 18/18639 0.111111111111111 1.62686567164179 0.350828299490332 0.751032433723748 GO:0070064 proline-rich region binding 2/1273 18/18639 0.111111111111111 1.62686567164179 0.350828299490332 0.751032433723748 GO:0070628 proteasome binding 2/1273 18/18639 0.111111111111111 1.62686567164179 0.350828299490332 0.751032433723748 GO:0098641 cadherin binding involved in cell-cell adhesion 2/1273 18/18639 0.111111111111111 1.62686567164179 0.350828299490332 0.751032433723748 GO:0099602 neurotransmitter receptor regulator activity 2/1273 18/18639 0.111111111111111 1.62686567164179 0.350828299490332 0.751032433723748 GO:1990381 ubiquitin-specific protease binding 2/1273 18/18639 0.111111111111111 1.62686567164179 0.350828299490332 0.751032433723748 GO:0016874 ligase activity 13/1273 167/18639 0.0778443113772455 1.13978014121012 0.353599849392598 0.754644359632142 GO:0004725 protein tyrosine phosphatase activity 8/1273 98/18639 0.0816326530612245 1.19524824855315 0.353821144395001 0.754644359632142 GO:0005164 tumor necrosis factor receptor binding 3/1273 31/18639 0.0967741935483871 1.41694752046221 0.356061715677821 0.75663114581537 GO:0008327 methyl-CpG binding 3/1273 31/18639 0.0967741935483871 1.41694752046221 0.356061715677821 0.75663114581537 GO:0008408 3'-5' exonuclease activity 5/1273 58/18639 0.0862068965517241 1.26222336592898 0.363207187919533 0.770399099513725 GO:0046915 transition metal ion transmembrane transporter activity 4/1273 45/18639 0.0888888888888889 1.30149253731343 0.369708378187884 0.77492252397497 GO:0043130 ubiquitin binding 8/1273 100/18639 0.08 1.17134328358209 0.374864269293867 0.77492252397497 GO:0015106 bicarbonate transmembrane transporter activity 3/1273 32/18639 0.09375 1.37266791044776 0.375120236400845 0.77492252397497 GO:0022884 macromolecule transmembrane transporter activity 3/1273 32/18639 0.09375 1.37266791044776 0.375120236400845 0.77492252397497 GO:0031369 translation initiation factor binding 3/1273 32/18639 0.09375 1.37266791044776 0.375120236400845 0.77492252397497 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 3/1273 32/18639 0.09375 1.37266791044776 0.375120236400845 0.77492252397497 GO:0043425 bHLH transcription factor binding 3/1273 32/18639 0.09375 1.37266791044776 0.375120236400845 0.77492252397497 GO:0140142 nucleocytoplasmic carrier activity 3/1273 32/18639 0.09375 1.37266791044776 0.375120236400845 0.77492252397497 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 2/1273 19/18639 0.105263157894737 1.54124116260801 0.376065342517265 0.77492252397497 GO:0004890 GABA-A receptor activity 2/1273 19/18639 0.105263157894737 1.54124116260801 0.376065342517265 0.77492252397497 GO:0005346 purine ribonucleotide transmembrane transporter activity 2/1273 19/18639 0.105263157894737 1.54124116260801 0.376065342517265 0.77492252397497 GO:0016918 retinal binding 2/1273 19/18639 0.105263157894737 1.54124116260801 0.376065342517265 0.77492252397497 GO:0030506 ankyrin binding 2/1273 19/18639 0.105263157894737 1.54124116260801 0.376065342517265 0.77492252397497 GO:0034987 immunoglobulin receptor binding 2/1273 19/18639 0.105263157894737 1.54124116260801 0.376065342517265 0.77492252397497 GO:0043395 heparan sulfate proteoglycan binding 2/1273 19/18639 0.105263157894737 1.54124116260801 0.376065342517265 0.77492252397497 GO:0046624 sphingolipid transporter activity 2/1273 19/18639 0.105263157894737 1.54124116260801 0.376065342517265 0.77492252397497 GO:0004521 RNA endonuclease activity 6/1273 73/18639 0.0821917808219178 1.20343488039256 0.381342009708785 0.784397443457928 GO:0030276 clathrin binding 4/1273 46/18639 0.0869565217391304 1.27319922128488 0.385549458355277 0.791643292821847 GO:0003684 damaged DNA binding 6/1273 74/18639 0.0810810810810811 1.18717224687374 0.393781784783216 0.805918250960934 GO:0030296 protein tyrosine kinase activator activity 3/1273 33/18639 0.0909090909090909 1.33107191316147 0.394061785926654 0.805918250960934 GO:0016298 lipase activity 10/1273 130/18639 0.0769230769230769 1.12629161882893 0.395891790433249 0.805918250960934 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 10/1273 130/18639 0.0769230769230769 1.12629161882893 0.395891790433249 0.805918250960934 GO:0015171 amino acid transmembrane transporter activity 8/1273 102/18639 0.0784313725490196 1.14837576821773 0.395987514312985 0.805918250960934 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 2/1273 20/18639 0.1 1.46417910447761 0.400886060174536 0.812518432264372 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 2/1273 20/18639 0.1 1.46417910447761 0.400886060174536 0.812518432264372 GO:0140359 ABC-type transporter activity 4/1273 47/18639 0.0851063829787234 1.24610987615116 0.401339121819166 0.812518432264372 GO:0003725 double-stranded RNA binding 6/1273 75/18639 0.08 1.17134328358209 0.406212499400153 0.820946939347162 GO:0016887 ATP hydrolysis activity 30/1273 417/18639 0.0719424460431655 1.05336626221411 0.410566977327066 0.82829917240853 GO:0008175 tRNA methyltransferase activity 3/1273 34/18639 0.0882352941176471 1.29192273924495 0.412849053969084 0.828565115257399 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 3/1273 34/18639 0.0882352941176471 1.29192273924495 0.412849053969084 0.828565115257399 GO:0090482 vitamin transmembrane transporter activity 3/1273 34/18639 0.0882352941176471 1.29192273924495 0.412849053969084 0.828565115257399 GO:0001846 opsonin binding 2/1273 21/18639 0.0952380952380952 1.39445628997868 0.425229603409565 0.843165388578829 GO:0005123 death receptor binding 2/1273 21/18639 0.0952380952380952 1.39445628997868 0.425229603409565 0.843165388578829 GO:0009931 calcium-dependent protein serine/threonine kinase activity 2/1273 21/18639 0.0952380952380952 1.39445628997868 0.425229603409565 0.843165388578829 GO:0015125 bile acid transmembrane transporter activity 2/1273 21/18639 0.0952380952380952 1.39445628997868 0.425229603409565 0.843165388578829 GO:0019200 carbohydrate kinase activity 2/1273 21/18639 0.0952380952380952 1.39445628997868 0.425229603409565 0.843165388578829 GO:0061891 calcium ion sensor activity 2/1273 21/18639 0.0952380952380952 1.39445628997868 0.425229603409565 0.843165388578829 GO:0070182 DNA polymerase binding 2/1273 21/18639 0.0952380952380952 1.39445628997868 0.425229603409565 0.843165388578829 GO:0042578 phosphoric ester hydrolase activity 26/1273 363/18639 0.0716253443526171 1.04872332552115 0.429691239426794 0.846780660734587 GO:0003724 RNA helicase activity 6/1273 77/18639 0.0779220779220779 1.14091878270983 0.430999004605831 0.846780660734587 GO:0051540 metal cluster binding 6/1273 77/18639 0.0779220779220779 1.14091878270983 0.430999004605831 0.846780660734587 GO:0005343 organic acid:sodium symporter activity 3/1273 35/18639 0.0857142857142857 1.25501066098081 0.43144793181027 0.846780660734587 GO:0016229 steroid dehydrogenase activity 3/1273 35/18639 0.0857142857142857 1.25501066098081 0.43144793181027 0.846780660734587 GO:0043015 gamma-tubulin binding 3/1273 35/18639 0.0857142857142857 1.25501066098081 0.43144793181027 0.846780660734587 GO:0015297 antiporter activity 10/1273 135/18639 0.0740740740740741 1.08457711442786 0.442639321271542 0.855463830646075 GO:0004536 DNA nuclease activity 5/1273 64/18639 0.078125 1.14388992537313 0.445854185213452 0.855463830646075 GO:0008649 rRNA methyltransferase activity 2/1273 22/18639 0.0909090909090909 1.33107191316147 0.449045363250737 0.855463830646075 GO:0015377 chloride:monoatomic cation symporter activity 2/1273 22/18639 0.0909090909090909 1.33107191316147 0.449045363250737 0.855463830646075 GO:0031683 G-protein beta/gamma-subunit complex binding 2/1273 22/18639 0.0909090909090909 1.33107191316147 0.449045363250737 0.855463830646075 GO:0034062 5'-3' RNA polymerase activity 2/1273 22/18639 0.0909090909090909 1.33107191316147 0.449045363250737 0.855463830646075 GO:0070034 telomerase RNA binding 2/1273 22/18639 0.0909090909090909 1.33107191316147 0.449045363250737 0.855463830646075 GO:0097747 RNA polymerase activity 2/1273 22/18639 0.0909090909090909 1.33107191316147 0.449045363250737 0.855463830646075 GO:0140035 ubiquitin-like protein reader activity 2/1273 22/18639 0.0909090909090909 1.33107191316147 0.449045363250737 0.855463830646075 GO:0140784 metal ion sensor activity 2/1273 22/18639 0.0909090909090909 1.33107191316147 0.449045363250737 0.855463830646075 GO:0004033 aldo-keto reductase (NADPH) activity 3/1273 36/18639 0.0833333333333333 1.22014925373134 0.449827415527471 0.855463830646075 GO:0016409 palmitoyltransferase activity 3/1273 36/18639 0.0833333333333333 1.22014925373134 0.449827415527471 0.855463830646075 GO:0044390 ubiquitin-like protein conjugating enzyme binding 3/1273 36/18639 0.0833333333333333 1.22014925373134 0.449827415527471 0.855463830646075 GO:0008186 ATP-dependent activity, acting on RNA 6/1273 79/18639 0.0759493670886076 1.11203476289439 0.455610007587592 0.855463830646075 GO:0016835 carbon-oxygen lyase activity 6/1273 79/18639 0.0759493670886076 1.11203476289439 0.455610007587592 0.855463830646075 GO:0004518 nuclease activity 15/1273 209/18639 0.0717703349282297 1.05084624723274 0.459727597153339 0.855463830646075 GO:0016410 N-acyltransferase activity 7/1273 94/18639 0.074468085106383 1.09034614163226 0.463314757933882 0.855463830646075 GO:0003743 translation initiation factor activity 4/1273 51/18639 0.0784313725490196 1.14837576821773 0.463539116739026 0.855463830646075 GO:0005048 signal sequence binding 4/1273 51/18639 0.0784313725490196 1.14837576821773 0.463539116739026 0.855463830646075 GO:0016597 amino acid binding 4/1273 51/18639 0.0784313725490196 1.14837576821773 0.463539116739026 0.855463830646075 GO:0140674 ATP-dependent histone chaperone activity 11/1273 152/18639 0.0723684210526316 1.05960329929301 0.466363786605796 0.855463830646075 GO:0000049 tRNA binding 6/1273 80/18639 0.075 1.09813432835821 0.467822910228833 0.855463830646075 GO:0019213 deacetylase activity 3/1273 37/18639 0.0810810810810811 1.18717224687374 0.467959496193981 0.855463830646075 GO:0022829 wide pore channel activity 3/1273 37/18639 0.0810810810810811 1.18717224687374 0.467959496193981 0.855463830646075 GO:0000295 adenine nucleotide transmembrane transporter activity 2/1273 23/18639 0.0869565217391304 1.27319922128488 0.472291857736087 0.855463830646075 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 2/1273 23/18639 0.0869565217391304 1.27319922128488 0.472291857736087 0.855463830646075 GO:0005283 amino acid:sodium symporter activity 2/1273 23/18639 0.0869565217391304 1.27319922128488 0.472291857736087 0.855463830646075 GO:0008171 O-methyltransferase activity 2/1273 23/18639 0.0869565217391304 1.27319922128488 0.472291857736087 0.855463830646075 GO:0016917 GABA receptor activity 2/1273 23/18639 0.0869565217391304 1.27319922128488 0.472291857736087 0.855463830646075 GO:0140102 catalytic activity, acting on a rRNA 2/1273 23/18639 0.0869565217391304 1.27319922128488 0.472291857736087 0.855463830646075 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 2/1273 23/18639 0.0869565217391304 1.27319922128488 0.472291857736087 0.855463830646075 GO:0004867 serine-type endopeptidase inhibitor activity 7/1273 95/18639 0.0736842105263158 1.07886881382561 0.474512120734064 0.855463830646075 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 4/1273 52/18639 0.0769230769230769 1.12629161882893 0.47874998380504 0.855463830646075 GO:0140101 catalytic activity, acting on a tRNA 10/1273 139/18639 0.0719424460431655 1.05336626221411 0.47978384868608 0.855463830646075 GO:0140098 catalytic activity, acting on RNA 27/1273 387/18639 0.0697674418604651 1.0215203054495 0.483164560261543 0.855463830646075 GO:0003713 transcription coactivator activity 18/1273 256/18639 0.0703125 1.02950093283582 0.484405163921339 0.855463830646075 GO:0005109 frizzled binding 3/1273 38/18639 0.0789473684210526 1.15593087195601 0.485819040049698 0.855463830646075 GO:0042887 amide transmembrane transporter activity 3/1273 38/18639 0.0789473684210526 1.15593087195601 0.485819040049698 0.855463830646075 GO:0008173 RNA methyltransferase activity 5/1273 67/18639 0.0746268656716418 1.09267097349076 0.486250434175002 0.855463830646075 GO:0004864 protein phosphatase inhibitor activity 4/1273 53/18639 0.0754716981132075 1.10504083356801 0.493790047338758 0.855463830646075 GO:0005246 calcium channel regulator activity 4/1273 53/18639 0.0754716981132075 1.10504083356801 0.493790047338758 0.855463830646075 GO:0005544 calcium-dependent phospholipid binding 4/1273 53/18639 0.0754716981132075 1.10504083356801 0.493790047338758 0.855463830646075 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 2/1273 24/18639 0.0833333333333333 1.22014925373134 0.494935722929062 0.855463830646075 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 2/1273 24/18639 0.0833333333333333 1.22014925373134 0.494935722929062 0.855463830646075 GO:0005315 phosphate transmembrane transporter activity 2/1273 24/18639 0.0833333333333333 1.22014925373134 0.494935722929062 0.855463830646075 GO:0015149 hexose transmembrane transporter activity 2/1273 24/18639 0.0833333333333333 1.22014925373134 0.494935722929062 0.855463830646075 GO:0015295 solute:proton symporter activity 2/1273 24/18639 0.0833333333333333 1.22014925373134 0.494935722929062 0.855463830646075 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 2/1273 24/18639 0.0833333333333333 1.22014925373134 0.494935722929062 0.855463830646075 GO:0050699 WW domain binding 2/1273 24/18639 0.0833333333333333 1.22014925373134 0.494935722929062 0.855463830646075 GO:0055056 D-glucose transmembrane transporter activity 2/1273 24/18639 0.0833333333333333 1.22014925373134 0.494935722929062 0.855463830646075 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 2/1273 24/18639 0.0833333333333333 1.22014925373134 0.494935722929062 0.855463830646075 GO:0003680 minor groove of adenine-thymine-rich DNA binding 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.855463830646075 GO:0003796 lysozyme activity 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.855463830646075 GO:0004382 GDP phosphatase activity 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.855463830646075 GO:0004862 cAMP-dependent protein kinase inhibitor activity 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.855463830646075 GO:0004935 adrenergic receptor activity 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.855463830646075 GO:0005522 profilin binding 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.855463830646075 GO:0008140 cAMP response element binding protein binding 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.855463830646075 GO:0008190 eukaryotic initiation factor 4E binding 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.855463830646075 GO:0008641 ubiquitin-like modifier activating enzyme activity 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.855463830646075 GO:0015187 glycine transmembrane transporter activity 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.855463830646075 GO:0015279 store-operated calcium channel activity 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.855463830646075 GO:0015643 toxic substance binding 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.855463830646075 GO:0015924 mannosyl-oligosaccharide mannosidase activity 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.855463830646075 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.855463830646075 GO:0016783 sulfurtransferase activity 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.855463830646075 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.855463830646075 GO:0016868 intramolecular phosphotransferase activity 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.855463830646075 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.855463830646075 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.855463830646075 GO:0030957 Tat protein binding 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.855463830646075 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.855463830646075 GO:0031419 cobalamin binding 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.855463830646075 GO:0031434 mitogen-activated protein kinase kinase binding 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.855463830646075 GO:0031957 very long-chain fatty acid-CoA ligase activity 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.855463830646075 GO:0032052 bile acid binding 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.855463830646075 GO:0032356 oxidized DNA binding 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.855463830646075 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.855463830646075 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.855463830646075 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.855463830646075 GO:0043208 glycosphingolipid binding 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.855463830646075 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.855463830646075 GO:0051378 serotonin binding 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.855463830646075 GO:0051880 G-quadruplex DNA binding 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.855463830646075 GO:0070097 delta-catenin binding 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.855463830646075 GO:0071723 lipopeptide binding 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.855463830646075 GO:0140135 mechanosensitive monoatomic cation channel activity 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.855463830646075 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.855463830646075 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.855463830646075 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.855463830646075 GO:0042626 ATPase-coupled transmembrane transporter activity 7/1273 98/18639 0.0714285714285714 1.04584221748401 0.507707974684204 0.855463830646075 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 4/1273 54/18639 0.0740740740740741 1.08457711442786 0.508644007686666 0.855463830646075 GO:0008080 N-acetyltransferase activity 5/1273 69/18639 0.072463768115942 1.06099935107073 0.512593266474751 0.855463830646075 GO:0004709 MAP kinase kinase kinase activity 2/1273 25/18639 0.08 1.17134328358209 0.516950799012555 0.855463830646075 GO:0015271 outward rectifier potassium channel activity 2/1273 25/18639 0.08 1.17134328358209 0.516950799012555 0.855463830646075 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 2/1273 25/18639 0.08 1.17134328358209 0.516950799012555 0.855463830646075 GO:0017025 TBP-class protein binding 2/1273 25/18639 0.08 1.17134328358209 0.516950799012555 0.855463830646075 GO:0019706 protein-cysteine S-palmitoyltransferase activity 2/1273 25/18639 0.08 1.17134328358209 0.516950799012555 0.855463830646075 GO:0019707 protein-cysteine S-acyltransferase activity 2/1273 25/18639 0.08 1.17134328358209 0.516950799012555 0.855463830646075 GO:0140658 ATP-dependent chromatin remodeler activity 11/1273 158/18639 0.069620253164557 1.01936519931986 0.518735965254394 0.855463830646075 GO:0015144 carbohydrate transmembrane transporter activity 3/1273 40/18639 0.075 1.09813432835821 0.520633589342093 0.855463830646075 GO:0030331 nuclear estrogen receptor binding 3/1273 40/18639 0.075 1.09813432835821 0.520633589342093 0.855463830646075 GO:0061791 GTPase motor activity 3/1273 40/18639 0.075 1.09813432835821 0.520633589342093 0.855463830646075 GO:1990606 membrane scission GTPase motor activity 3/1273 40/18639 0.075 1.09813432835821 0.520633589342093 0.855463830646075 GO:0046943 carboxylic acid transmembrane transporter activity 13/1273 188/18639 0.0691489361702128 1.01246427437282 0.5229630913081 0.855463830646075 GO:0035591 signaling adaptor activity 9/1273 129/18639 0.0697674418604651 1.0215203054495 0.523336289143615 0.855463830646075 GO:0008028 monocarboxylic acid transmembrane transporter activity 5/1273 70/18639 0.0714285714285714 1.04584221748401 0.525554746759389 0.855463830646075 GO:0005342 organic acid transmembrane transporter activity 13/1273 189/18639 0.0687830687830688 1.00710732054016 0.530836653330844 0.855463830646075 GO:0015175 neutral L-amino acid transmembrane transporter activity 3/1273 41/18639 0.0731707317073171 1.07135056425191 0.537551533664643 0.855463830646075 GO:0016877 ligase activity, forming carbon-sulfur bonds 3/1273 41/18639 0.0731707317073171 1.07135056425191 0.537551533664643 0.855463830646075 GO:0019212 phosphatase inhibitor activity 4/1273 56/18639 0.0714285714285714 1.04584221748401 0.537738702521115 0.855463830646075 GO:0030170 pyridoxal phosphate binding 4/1273 56/18639 0.0714285714285714 1.04584221748401 0.537738702521115 0.855463830646075 GO:0170055 lipid transmembrane transporter activity 4/1273 56/18639 0.0714285714285714 1.04584221748401 0.537738702521115 0.855463830646075 GO:0008066 glutamate receptor activity 2/1273 26/18639 0.0769230769230769 1.12629161882893 0.538317303196011 0.855463830646075 GO:0015145 monosaccharide transmembrane transporter activity 2/1273 26/18639 0.0769230769230769 1.12629161882893 0.538317303196011 0.855463830646075 GO:0015216 purine nucleotide transmembrane transporter activity 2/1273 26/18639 0.0769230769230769 1.12629161882893 0.538317303196011 0.855463830646075 GO:0030247 polysaccharide binding 2/1273 26/18639 0.0769230769230769 1.12629161882893 0.538317303196011 0.855463830646075 GO:0030507 spectrin binding 2/1273 26/18639 0.0769230769230769 1.12629161882893 0.538317303196011 0.855463830646075 GO:0051139 metal cation:proton antiporter activity 2/1273 26/18639 0.0769230769230769 1.12629161882893 0.538317303196011 0.855463830646075 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 6/1273 86/18639 0.0697674418604651 1.0215203054495 0.539205418708581 0.855463830646075 GO:0002162 dystroglycan binding 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.855463830646075 GO:0003953 NAD+ nucleosidase activity 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.855463830646075 GO:0004523 RNA-DNA hybrid ribonuclease activity 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.855463830646075 GO:0008046 axon guidance receptor activity 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.855463830646075 GO:0008199 ferric iron binding 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.855463830646075 GO:0008432 JUN kinase binding 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.855463830646075 GO:0015173 aromatic amino acid transmembrane transporter activity 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.855463830646075 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.855463830646075 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.855463830646075 GO:0019107 myristoyltransferase activity 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.855463830646075 GO:0019206 nucleoside kinase activity 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.855463830646075 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.855463830646075 GO:0034056 estrogen response element binding 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.855463830646075 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.855463830646075 GO:0045294 alpha-catenin binding 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.855463830646075 GO:0047676 arachidonate-CoA ligase activity 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.855463830646075 GO:0050786 RAGE receptor binding 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.855463830646075 GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.855463830646075 GO:0140537 transcription regulator activator activity 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.855463830646075 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.855463830646075 GO:0015294 solute:monoatomic cation symporter activity 8/1273 116/18639 0.0689655172413793 1.00977869274318 0.541179197053552 0.855463830646075 GO:0015293 symporter activity 10/1273 146/18639 0.0684931506849315 1.00286240032713 0.543287324717962 0.855463830646075 GO:0042379 chemokine receptor binding 5/1273 72/18639 0.0694444444444444 1.01679104477612 0.551009123858657 0.855463830646075 GO:0070279 vitamin B6 binding 4/1273 57/18639 0.0701754385964912 1.02749410840534 0.551955024280155 0.855463830646075 GO:0031492 nucleosomal DNA binding 3/1273 42/18639 0.0714285714285714 1.04584221748401 0.554122545860698 0.855463830646075 GO:0035198 miRNA binding 3/1273 42/18639 0.0714285714285714 1.04584221748401 0.554122545860698 0.855463830646075 GO:0001671 ATPase activator activity 2/1273 27/18639 0.0740740740740741 1.08457711442786 0.559021081854555 0.855463830646075 GO:0004683 calcium/calmodulin-dependent protein kinase activity 2/1273 27/18639 0.0740740740740741 1.08457711442786 0.559021081854555 0.855463830646075 GO:0005104 fibroblast growth factor receptor binding 2/1273 27/18639 0.0740740740740741 1.08457711442786 0.559021081854555 0.855463830646075 GO:0005385 zinc ion transmembrane transporter activity 2/1273 27/18639 0.0740740740740741 1.08457711442786 0.559021081854555 0.855463830646075 GO:0016405 CoA-ligase activity 2/1273 27/18639 0.0740740740740741 1.08457711442786 0.559021081854555 0.855463830646075 GO:0140996 histone H3 kinase activity 24/1273 357/18639 0.0672268907563025 0.984322087043773 0.562871300688367 0.855463830646075 GO:0140713 histone chaperone activity 11/1273 164/18639 0.0670731707317073 0.982071350564252 0.569461614216922 0.855463830646075 GO:0008375 acetylglucosaminyltransferase activity 3/1273 43/18639 0.0697674418604651 1.0215203054495 0.570333882352448 0.855463830646075 GO:0000995 RNA polymerase III general transcription initiation factor activity 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.855463830646075 GO:0004859 phospholipase inhibitor activity 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.855463830646075 GO:0005095 GTPase inhibitor activity 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.855463830646075 GO:0008603 cAMP-dependent protein kinase regulator activity 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.855463830646075 GO:0015166 polyol transmembrane transporter activity 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.855463830646075 GO:0015368 calcium:monoatomic cation antiporter activity 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.855463830646075 GO:0016273 arginine N-methyltransferase activity 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.855463830646075 GO:0016274 protein-arginine N-methyltransferase activity 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.855463830646075 GO:0016423 tRNA (guanine) methyltransferase activity 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.855463830646075 GO:0017166 vinculin binding 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.855463830646075 GO:0035014 phosphatidylinositol 3-kinase regulator activity 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.855463830646075 GO:0035251 UDP-glucosyltransferase activity 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.855463830646075 GO:0035259 nuclear glucocorticoid receptor binding 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.855463830646075 GO:0035497 cAMP response element binding 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.855463830646075 GO:0042301 phosphate ion binding 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.855463830646075 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.855463830646075 GO:0070679 inositol 1,4,5 trisphosphate binding 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.855463830646075 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.855463830646075 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.855463830646075 GO:0140829 bicarbonate:monoatomic anion antiporter activity 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.855463830646075 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.855463830646075 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.855463830646075 GO:0140900 chloride:bicarbonate antiporter activity 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.855463830646075 GO:0141221 histone deacetylase activity, hydrolytic mechanism 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.855463830646075 GO:1990459 transferrin receptor binding 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.855463830646075 GO:0019789 SUMO transferase activity 2/1273 28/18639 0.0714285714285714 1.04584221748401 0.579052934948466 0.855463830646075 GO:0046966 nuclear thyroid hormone receptor binding 2/1273 28/18639 0.0714285714285714 1.04584221748401 0.579052934948466 0.855463830646075 GO:0051119 sugar transmembrane transporter activity 2/1273 28/18639 0.0714285714285714 1.04584221748401 0.579052934948466 0.855463830646075 GO:0141052 histone H3 demethylase activity 2/1273 28/18639 0.0714285714285714 1.04584221748401 0.579052934948466 0.855463830646075 GO:0031593 polyubiquitin modification-dependent protein binding 4/1273 59/18639 0.0677966101694915 0.992663799645839 0.579673338513842 0.855463830646075 GO:0070063 RNA polymerase binding 4/1273 59/18639 0.0677966101694915 0.992663799645839 0.579673338513842 0.855463830646075 GO:0035173 histone kinase activity 24/1273 360/18639 0.0666666666666667 0.976119402985075 0.579777255303525 0.855463830646075 GO:0032182 ubiquitin-like protein binding 8/1273 120/18639 0.0666666666666667 0.976119402985075 0.580301714341846 0.855463830646075 GO:0043014 alpha-tubulin binding 3/1273 44/18639 0.0681818181818182 0.998303934871099 0.586174867681593 0.855463830646075 GO:0000510 H3-H4 histone complex chaperone activity 10/1273 151/18639 0.0662251655629139 0.969655036077889 0.586836087009682 0.855463830646075 GO:0140584 chromatin extrusion motor activity 10/1273 151/18639 0.0662251655629139 0.969655036077889 0.586836087009682 0.855463830646075 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 10/1273 151/18639 0.0662251655629139 0.969655036077889 0.586836087009682 0.855463830646075 GO:0140849 ATP-dependent H2AZ histone chaperone activity 10/1273 151/18639 0.0662251655629139 0.969655036077889 0.586836087009682 0.855463830646075 GO:0004540 RNA nuclease activity 8/1273 121/18639 0.0661157024793388 0.968052300481066 0.589837447826642 0.855463830646075 GO:0015291 secondary active transmembrane transporter activity 19/1273 287/18639 0.0662020905923345 0.969317177180301 0.590379612795978 0.855463830646075 GO:0008013 beta-catenin binding 7/1273 106/18639 0.0660377358490566 0.966910729372008 0.592158669245003 0.855463830646075 GO:0015616 DNA translocase activity 10/1273 152/18639 0.0657894736842105 0.963275726630008 0.595320051826857 0.855463830646075 GO:0016791 phosphatase activity 18/1273 273/18639 0.0659340659340659 0.965392816139085 0.596785927630908 0.855463830646075 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 2/1273 29/18639 0.0689655172413793 1.00977869274318 0.598408006350198 0.855463830646075 GO:0016417 S-acyltransferase activity 2/1273 29/18639 0.0689655172413793 1.00977869274318 0.598408006350198 0.855463830646075 GO:0097472 cyclin-dependent protein kinase activity 2/1273 29/18639 0.0689655172413793 1.00977869274318 0.598408006350198 0.855463830646075 GO:0051536 iron-sulfur cluster binding 5/1273 76/18639 0.0657894736842105 0.963275726630008 0.599814618901421 0.855463830646075 GO:0004465 lipoprotein lipase activity 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.855463830646075 GO:0004535 poly(A)-specific ribonuclease activity 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.855463830646075 GO:0004993 G protein-coupled serotonin receptor activity 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.855463830646075 GO:0005542 folic acid binding 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.855463830646075 GO:0008035 high-density lipoprotein particle binding 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.855463830646075 GO:0015651 quaternary ammonium group transmembrane transporter activity 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.855463830646075 GO:0017154 semaphorin receptor activity 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.855463830646075 GO:0019855 calcium channel inhibitor activity 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.855463830646075 GO:0030955 potassium ion binding 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.855463830646075 GO:0035325 Toll-like receptor binding 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.855463830646075 GO:0035673 oligopeptide transmembrane transporter activity 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.855463830646075 GO:0039706 co-receptor binding 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.855463830646075 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.855463830646075 GO:0045159 myosin II binding 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.855463830646075 GO:0051011 microtubule minus-end binding 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.855463830646075 GO:0071714 icosanoid transmembrane transporter activity 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.855463830646075 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.855463830646075 GO:0140666 annealing activity 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.855463830646075 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.855463830646075 GO:0140852 histone ubiquitin ligase activity 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.855463830646075 GO:1901338 catecholamine binding 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.855463830646075 GO:0051539 4 iron, 4 sulfur cluster binding 3/1273 45/18639 0.0666666666666667 0.976119402985075 0.601636759788286 0.855463830646075 GO:0140303 intramembrane lipid transporter activity 3/1273 45/18639 0.0666666666666667 0.976119402985075 0.601636759788286 0.855463830646075 GO:0061775 cohesin loader activity 10/1273 153/18639 0.065359477124183 0.956979806848112 0.603721883664718 0.857374075572991 GO:0016836 hydro-lyase activity 4/1273 61/18639 0.0655737704918033 0.96011744555909 0.606382374550502 0.860095736172246 GO:0005085 guanyl-nucleotide exchange factor activity 15/1273 230/18639 0.0652173913043478 0.95489941596366 0.611750792274595 0.862703179525974 GO:0004180 carboxypeptidase activity 3/1273 46/18639 0.0652173913043478 0.95489941596366 0.616712618027798 0.862703179525974 GO:0001965 G-protein alpha-subunit binding 2/1273 30/18639 0.0666666666666667 0.976119402985075 0.617085234238437 0.862703179525974 GO:0008106 alcohol dehydrogenase (NADP+) activity 2/1273 30/18639 0.0666666666666667 0.976119402985075 0.617085234238437 0.862703179525974 GO:0031624 ubiquitin conjugating enzyme binding 2/1273 30/18639 0.0666666666666667 0.976119402985075 0.617085234238437 0.862703179525974 GO:0032452 histone demethylase activity 2/1273 30/18639 0.0666666666666667 0.976119402985075 0.617085234238437 0.862703179525974 GO:0033612 receptor serine/threonine kinase binding 2/1273 30/18639 0.0666666666666667 0.976119402985075 0.617085234238437 0.862703179525974 GO:0048019 receptor antagonist activity 2/1273 30/18639 0.0666666666666667 0.976119402985075 0.617085234238437 0.862703179525974 GO:0051721 protein phosphatase 2A binding 2/1273 30/18639 0.0666666666666667 0.976119402985075 0.617085234238437 0.862703179525974 GO:0003730 mRNA 3'-UTR binding 17/1273 262/18639 0.0648854961832061 0.950039876951122 0.622757217696842 0.862703179525974 GO:0004065 arylsulfatase activity 1/1273 14/18639 0.0714285714285714 1.04584221748401 0.62869984524637 0.862703179525974 GO:0004705 JUN kinase activity 1/1273 14/18639 0.0714285714285714 1.04584221748401 0.62869984524637 0.862703179525974 GO:0005313 L-glutamate transmembrane transporter activity 1/1273 14/18639 0.0714285714285714 1.04584221748401 0.62869984524637 0.862703179525974 GO:0005545 1-phosphatidylinositol binding 1/1273 14/18639 0.0714285714285714 1.04584221748401 0.62869984524637 0.862703179525974 GO:0008174 mRNA methyltransferase activity 1/1273 14/18639 0.0714285714285714 1.04584221748401 0.62869984524637 0.862703179525974 GO:0008331 high voltage-gated calcium channel activity 1/1273 14/18639 0.0714285714285714 1.04584221748401 0.62869984524637 0.862703179525974 GO:0008494 translation activator activity 1/1273 14/18639 0.0714285714285714 1.04584221748401 0.62869984524637 0.862703179525974 GO:0008559 ABC-type xenobiotic transporter activity 1/1273 14/18639 0.0714285714285714 1.04584221748401 0.62869984524637 0.862703179525974 GO:0015926 glucosidase activity 1/1273 14/18639 0.0714285714285714 1.04584221748401 0.62869984524637 0.862703179525974 GO:0016530 metallochaperone activity 1/1273 14/18639 0.0714285714285714 1.04584221748401 0.62869984524637 0.862703179525974 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 1/1273 14/18639 0.0714285714285714 1.04584221748401 0.62869984524637 0.862703179525974 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 1/1273 14/18639 0.0714285714285714 1.04584221748401 0.62869984524637 0.862703179525974 GO:0034236 protein kinase A catalytic subunit binding 1/1273 14/18639 0.0714285714285714 1.04584221748401 0.62869984524637 0.862703179525974 GO:0042813 Wnt receptor activity 1/1273 14/18639 0.0714285714285714 1.04584221748401 0.62869984524637 0.862703179525974 GO:0046030 inositol trisphosphate phosphatase activity 1/1273 14/18639 0.0714285714285714 1.04584221748401 0.62869984524637 0.862703179525974 GO:0061783 peptidoglycan muralytic activity 1/1273 14/18639 0.0714285714285714 1.04584221748401 0.62869984524637 0.862703179525974 GO:0070742 C2H2 zinc finger domain binding 1/1273 14/18639 0.0714285714285714 1.04584221748401 0.62869984524637 0.862703179525974 GO:0141003 histone H2AX kinase activity 23/1273 354/18639 0.0649717514124294 0.951302807993929 0.629544028480383 0.862703179525974 GO:0061733 protein-lysine-acetyltransferase activity 3/1273 47/18639 0.0638297872340425 0.934582407113369 0.631397174587478 0.862703179525974 GO:0005310 dicarboxylic acid transmembrane transporter activity 2/1273 31/18639 0.0645161290322581 0.944631680308137 0.635086856208135 0.862703179525974 GO:0005452 solute:inorganic anion antiporter activity 2/1273 31/18639 0.0645161290322581 0.944631680308137 0.635086856208135 0.862703179525974 GO:0016878 acid-thiol ligase activity 2/1273 31/18639 0.0645161290322581 0.944631680308137 0.635086856208135 0.862703179525974 GO:0017147 Wnt-protein binding 2/1273 31/18639 0.0645161290322581 0.944631680308137 0.635086856208135 0.862703179525974 GO:0047499 calcium-independent phospholipase A2 activity 2/1273 31/18639 0.0645161290322581 0.944631680308137 0.635086856208135 0.862703179525974 GO:0072349 modified amino acid transmembrane transporter activity 2/1273 31/18639 0.0645161290322581 0.944631680308137 0.635086856208135 0.862703179525974 GO:0140457 protein demethylase activity 2/1273 31/18639 0.0645161290322581 0.944631680308137 0.635086856208135 0.862703179525974 GO:1902936 phosphatidylinositol bisphosphate binding 7/1273 111/18639 0.0630630630630631 0.923356192012908 0.641016985336284 0.868098713672354 GO:0004519 endonuclease activity 8/1273 127/18639 0.062992125984252 0.92231754612763 0.644712099583649 0.868098713672354 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 3/1273 48/18639 0.0625 0.915111940298508 0.645686709835802 0.868098713672354 GO:0047498 calcium-dependent phospholipase A2 activity 2/1273 32/18639 0.0625 0.915111940298508 0.652417964195288 0.868098713672354 GO:0051059 NF-kappaB binding 2/1273 32/18639 0.0625 0.915111940298508 0.652417964195288 0.868098713672354 GO:0004467 long-chain fatty acid-CoA ligase activity 1/1273 15/18639 0.0666666666666667 0.976119402985075 0.654077837031679 0.868098713672354 GO:0004559 alpha-mannosidase activity 1/1273 15/18639 0.0666666666666667 0.976119402985075 0.654077837031679 0.868098713672354 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 1/1273 15/18639 0.0666666666666667 0.976119402985075 0.654077837031679 0.868098713672354 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 1/1273 15/18639 0.0666666666666667 0.976119402985075 0.654077837031679 0.868098713672354 GO:0004865 protein serine/threonine phosphatase inhibitor activity 1/1273 15/18639 0.0666666666666667 0.976119402985075 0.654077837031679 0.868098713672354 GO:0010181 FMN binding 1/1273 15/18639 0.0666666666666667 0.976119402985075 0.654077837031679 0.868098713672354 GO:0015250 water channel activity 1/1273 15/18639 0.0666666666666667 0.976119402985075 0.654077837031679 0.868098713672354 GO:0015929 hexosaminidase activity 1/1273 15/18639 0.0666666666666667 0.976119402985075 0.654077837031679 0.868098713672354 GO:0033130 acetylcholine receptor binding 1/1273 15/18639 0.0666666666666667 0.976119402985075 0.654077837031679 0.868098713672354 GO:0034483 heparan sulfate sulfotransferase activity 1/1273 15/18639 0.0666666666666667 0.976119402985075 0.654077837031679 0.868098713672354 GO:0047372 monoacylglycerol lipase activity 1/1273 15/18639 0.0666666666666667 0.976119402985075 0.654077837031679 0.868098713672354 GO:0050780 dopamine receptor binding 1/1273 15/18639 0.0666666666666667 0.976119402985075 0.654077837031679 0.868098713672354 GO:0120283 protein serine/threonine kinase binding 1/1273 15/18639 0.0666666666666667 0.976119402985075 0.654077837031679 0.868098713672354 GO:0141050 histone H3K deacetylase activity 1/1273 15/18639 0.0666666666666667 0.976119402985075 0.654077837031679 0.868098713672354 GO:0141051 histone H4K deacetylase activity 1/1273 15/18639 0.0666666666666667 0.976119402985075 0.654077837031679 0.868098713672354 GO:0015101 organic cation transmembrane transporter activity 5/1273 81/18639 0.0617283950617284 0.903814262023217 0.65636552735741 0.870135951405006 GO:0035254 glutamate receptor binding 3/1273 49/18639 0.0612244897959184 0.896436186414864 0.659578932021079 0.872990867007717 GO:0003689 DNA clamp loader activity 10/1273 160/18639 0.0625 0.915111940298508 0.660029427132132 0.872990867007717 GO:0005249 voltage-gated potassium channel activity 6/1273 98/18639 0.0612244897959184 0.896436186414864 0.667352161163065 0.87633921039252 GO:0008170 N-methyltransferase activity 6/1273 98/18639 0.0612244897959184 0.896436186414864 0.667352161163065 0.87633921039252 GO:0019956 chemokine binding 2/1273 33/18639 0.0606060606060606 0.887381275440977 0.669086104728748 0.87633921039252 GO:0140311 protein sequestering activity 2/1273 33/18639 0.0606060606060606 0.887381275440977 0.669086104728748 0.87633921039252 GO:0015605 organophosphate ester transmembrane transporter activity 3/1273 50/18639 0.06 0.878507462686567 0.673072861638011 0.87633921039252 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 1/1273 16/18639 0.0625 0.915111940298508 0.677722538140928 0.87633921039252 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 1/1273 16/18639 0.0625 0.915111940298508 0.677722538140928 0.87633921039252 GO:0004707 MAP kinase activity 1/1273 16/18639 0.0625 0.915111940298508 0.677722538140928 0.87633921039252 GO:0004708 MAP kinase kinase activity 1/1273 16/18639 0.0625 0.915111940298508 0.677722538140928 0.87633921039252 GO:0005024 transforming growth factor beta receptor activity 1/1273 16/18639 0.0625 0.915111940298508 0.677722538140928 0.87633921039252 GO:0005324 long-chain fatty acid transmembrane transporter activity 1/1273 16/18639 0.0625 0.915111940298508 0.677722538140928 0.87633921039252 GO:0005521 lamin binding 1/1273 16/18639 0.0625 0.915111940298508 0.677722538140928 0.87633921039252 GO:0008296 3'-5'-DNA exonuclease activity 1/1273 16/18639 0.0625 0.915111940298508 0.677722538140928 0.87633921039252 GO:0015378 sodium:chloride symporter activity 1/1273 16/18639 0.0625 0.915111940298508 0.677722538140928 0.87633921039252 GO:0015562 efflux transmembrane transporter activity 1/1273 16/18639 0.0625 0.915111940298508 0.677722538140928 0.87633921039252 GO:0015923 mannosidase activity 1/1273 16/18639 0.0625 0.915111940298508 0.677722538140928 0.87633921039252 GO:0022841 potassium ion leak channel activity 1/1273 16/18639 0.0625 0.915111940298508 0.677722538140928 0.87633921039252 GO:0055102 lipase inhibitor activity 1/1273 16/18639 0.0625 0.915111940298508 0.677722538140928 0.87633921039252 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 1/1273 16/18639 0.0625 0.915111940298508 0.677722538140928 0.87633921039252 GO:0097027 ubiquitin-protein transferase activator activity 1/1273 16/18639 0.0625 0.915111940298508 0.677722538140928 0.87633921039252 GO:0008376 acetylgalactosaminyltransferase activity 2/1273 34/18639 0.0588235294117647 0.861281826163301 0.685100920401227 0.882325963428801 GO:0019825 oxygen binding 2/1273 34/18639 0.0588235294117647 0.861281826163301 0.685100920401227 0.882325963428801 GO:0030332 cyclin binding 2/1273 34/18639 0.0588235294117647 0.861281826163301 0.685100920401227 0.882325963428801 GO:0016830 carbon-carbon lyase activity 3/1273 51/18639 0.0588235294117647 0.861281826163301 0.686168720694197 0.882325963428801 GO:0030544 Hsp70 protein binding 3/1273 51/18639 0.0588235294117647 0.861281826163301 0.686168720694197 0.882325963428801 GO:0004549 tRNA-specific ribonuclease activity 1/1273 17/18639 0.0588235294117647 0.861281826163301 0.699752243824578 0.887225742207396 GO:0004550 nucleoside diphosphate kinase activity 1/1273 17/18639 0.0588235294117647 0.861281826163301 0.699752243824578 0.887225742207396 GO:0008429 phosphatidylethanolamine binding 1/1273 17/18639 0.0588235294117647 0.861281826163301 0.699752243824578 0.887225742207396 GO:0016805 dipeptidase activity 1/1273 17/18639 0.0588235294117647 0.861281826163301 0.699752243824578 0.887225742207396 GO:0017110 nucleoside diphosphate phosphatase activity 1/1273 17/18639 0.0588235294117647 0.861281826163301 0.699752243824578 0.887225742207396 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 1/1273 17/18639 0.0588235294117647 0.861281826163301 0.699752243824578 0.887225742207396 GO:0036041 long-chain fatty acid binding 1/1273 17/18639 0.0588235294117647 0.861281826163301 0.699752243824578 0.887225742207396 GO:0038191 neuropilin binding 1/1273 17/18639 0.0588235294117647 0.861281826163301 0.699752243824578 0.887225742207396 GO:0070402 NADPH binding 1/1273 17/18639 0.0588235294117647 0.861281826163301 0.699752243824578 0.887225742207396 GO:1990226 histone methyltransferase binding 1/1273 17/18639 0.0588235294117647 0.861281826163301 0.699752243824578 0.887225742207396 GO:0000175 3'-5'-RNA exonuclease activity 2/1273 35/18639 0.0571428571428571 0.836673773987207 0.700473828800679 0.887225742207396 GO:0004623 phospholipase A2 activity 2/1273 35/18639 0.0571428571428571 0.836673773987207 0.700473828800679 0.887225742207396 GO:0061631 ubiquitin conjugating enzyme activity 2/1273 35/18639 0.0571428571428571 0.836673773987207 0.700473828800679 0.887225742207396 GO:0016758 hexosyltransferase activity 12/1273 197/18639 0.0609137055837563 0.891885748920373 0.700724137227814 0.887225742207396 GO:1901505 carbohydrate derivative transmembrane transporter activity 3/1273 53/18639 0.0566037735849057 0.828780625176007 0.711172493816085 0.896276019457417 GO:0016741 transferase activity, transferring one-carbon groups 13/1273 215/18639 0.0604651162790698 0.88531759805623 0.715146201120674 0.896276019457417 GO:0004190 aspartic-type endopeptidase activity 2/1273 36/18639 0.0555555555555556 0.813432835820896 0.715217735463809 0.896276019457417 GO:0004869 cysteine-type endopeptidase inhibitor activity 2/1273 36/18639 0.0555555555555556 0.813432835820896 0.715217735463809 0.896276019457417 GO:0035402 histone H3T11 kinase activity 15/1273 247/18639 0.0607287449392713 0.889177593812315 0.71851979898044 0.896276019457417 GO:0000900 mRNA regulatory element binding translation repressor activity 1/1273 18/18639 0.0555555555555556 0.813432835820896 0.720277181726592 0.896276019457417 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 1/1273 18/18639 0.0555555555555556 0.813432835820896 0.720277181726592 0.896276019457417 GO:0004970 glutamate-gated receptor activity 1/1273 18/18639 0.0555555555555556 0.813432835820896 0.720277181726592 0.896276019457417 GO:0005372 water transmembrane transporter activity 1/1273 18/18639 0.0555555555555556 0.813432835820896 0.720277181726592 0.896276019457417 GO:0008409 5'-3' exonuclease activity 1/1273 18/18639 0.0555555555555556 0.813432835820896 0.720277181726592 0.896276019457417 GO:0015373 monoatomic anion:sodium symporter activity 1/1273 18/18639 0.0555555555555556 0.813432835820896 0.720277181726592 0.896276019457417 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 1/1273 18/18639 0.0555555555555556 0.813432835820896 0.720277181726592 0.896276019457417 GO:0017075 syntaxin-1 binding 1/1273 18/18639 0.0555555555555556 0.813432835820896 0.720277181726592 0.896276019457417 GO:0034185 apolipoprotein binding 1/1273 18/18639 0.0555555555555556 0.813432835820896 0.720277181726592 0.896276019457417 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 1/1273 18/18639 0.0555555555555556 0.813432835820896 0.720277181726592 0.896276019457417 GO:0050811 GABA receptor binding 1/1273 18/18639 0.0555555555555556 0.813432835820896 0.720277181726592 0.896276019457417 GO:0140463 chromatin-protein adaptor activity 3/1273 54/18639 0.0555555555555556 0.813432835820896 0.72308593417664 0.898803591299135 GO:0030551 cyclic nucleotide binding 2/1273 37/18639 0.0540540540540541 0.791448164582493 0.729346777707799 0.904640423852163 GO:0070001 aspartic-type peptidase activity 2/1273 37/18639 0.0540540540540541 0.791448164582493 0.729346777707799 0.904640423852163 GO:0005506 iron ion binding 9/1273 154/18639 0.0584415584415584 0.855689087032371 0.732392224305894 0.906411952603565 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 1/1273 19/18639 0.0526315789473684 0.770620581304006 0.739400061682666 0.906411952603565 GO:0008381 mechanosensitive monoatomic ion channel activity 1/1273 19/18639 0.0526315789473684 0.770620581304006 0.739400061682666 0.906411952603565 GO:0015245 fatty acid transmembrane transporter activity 1/1273 19/18639 0.0526315789473684 0.770620581304006 0.739400061682666 0.906411952603565 GO:0022840 leak channel activity 1/1273 19/18639 0.0526315789473684 0.770620581304006 0.739400061682666 0.906411952603565 GO:0022842 narrow pore channel activity 1/1273 19/18639 0.0526315789473684 0.770620581304006 0.739400061682666 0.906411952603565 GO:0031420 alkali metal ion binding 1/1273 19/18639 0.0526315789473684 0.770620581304006 0.739400061682666 0.906411952603565 GO:0042834 peptidoglycan binding 1/1273 19/18639 0.0526315789473684 0.770620581304006 0.739400061682666 0.906411952603565 GO:0046527 glucosyltransferase activity 1/1273 19/18639 0.0526315789473684 0.770620581304006 0.739400061682666 0.906411952603565 GO:0099589 serotonin receptor activity 1/1273 19/18639 0.0526315789473684 0.770620581304006 0.739400061682666 0.906411952603565 GO:0140036 ubiquitin-modified protein reader activity 1/1273 19/18639 0.0526315789473684 0.770620581304006 0.739400061682666 0.906411952603565 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 2/1273 38/18639 0.0526315789473684 0.770620581304006 0.742876096466582 0.909708440164586 GO:0008168 methyltransferase activity 12/1273 204/18639 0.0588235294117647 0.861281826163301 0.7445170892828 0.910753180117373 GO:0140375 immune receptor activity 9/1273 156/18639 0.0576923076923077 0.844718714121699 0.746093456387705 0.911716739518168 GO:0015932 nucleobase-containing compound transmembrane transporter activity 3/1273 57/18639 0.0526315789473684 0.770620581304006 0.756522670547469 0.915630100228004 GO:0030695 GTPase regulator activity 30/1273 489/18639 0.0613496932515337 0.898269389250069 0.756673585334705 0.915630100228004 GO:0000339 RNA cap binding 1/1273 20/18639 0.05 0.732089552238806 0.75721658807783 0.915630100228004 GO:0001614 purinergic nucleotide receptor activity 1/1273 20/18639 0.05 0.732089552238806 0.75721658807783 0.915630100228004 GO:0015095 magnesium ion transmembrane transporter activity 1/1273 20/18639 0.05 0.732089552238806 0.75721658807783 0.915630100228004 GO:0016502 nucleotide receptor activity 1/1273 20/18639 0.05 0.732089552238806 0.75721658807783 0.915630100228004 GO:0030627 pre-mRNA 5'-splice site binding 1/1273 20/18639 0.05 0.732089552238806 0.75721658807783 0.915630100228004 GO:0052745 inositol phosphate phosphatase activity 1/1273 20/18639 0.05 0.732089552238806 0.75721658807783 0.915630100228004 GO:0061608 nuclear import signal receptor activity 1/1273 20/18639 0.05 0.732089552238806 0.75721658807783 0.915630100228004 GO:0140939 histone H4 methyltransferase activity 1/1273 20/18639 0.05 0.732089552238806 0.75721658807783 0.915630100228004 GO:0060589 nucleoside-triphosphatase regulator activity 30/1273 490/18639 0.0612244897959184 0.896436186414864 0.760460346412615 0.918591599219418 GO:0061980 regulatory RNA binding 3/1273 58/18639 0.0517241379310345 0.757334019557386 0.766918288277764 0.924078193623947 GO:0004532 RNA exonuclease activity 2/1273 40/18639 0.05 0.732089552238806 0.768199951619907 0.924078193623947 GO:0032451 demethylase activity 2/1273 40/18639 0.05 0.732089552238806 0.768199951619907 0.924078193623947 GO:0071855 neuropeptide receptor binding 2/1273 40/18639 0.05 0.732089552238806 0.768199951619907 0.924078193623947 GO:0140097 catalytic activity, acting on DNA 20/1273 336/18639 0.0595238095238095 0.871535181236674 0.770166517328556 0.92548076302683 GO:0015174 basic amino acid transmembrane transporter activity 1/1273 21/18639 0.0476190476190476 0.697228144989339 0.773815937311244 0.926975361172847 GO:0051428 peptide hormone receptor binding 1/1273 21/18639 0.0476190476190476 0.697228144989339 0.773815937311244 0.926975361172847 GO:1904047 S-adenosyl-L-methionine binding 1/1273 21/18639 0.0476190476190476 0.697228144989339 0.773815937311244 0.926975361172847 GO:0036002 pre-mRNA binding 3/1273 59/18639 0.0508474576271186 0.744497849734379 0.776949267729403 0.928643105472669 GO:0008094 ATP-dependent activity, acting on DNA 12/1273 210/18639 0.0571428571428571 0.836673773987207 0.778495007314528 0.928643105472669 GO:0004812 aminoacyl-tRNA ligase activity 2/1273 41/18639 0.0487804878048781 0.714233709501274 0.780028075617613 0.928643105472669 GO:0008227 G protein-coupled amine receptor activity 2/1273 41/18639 0.0487804878048781 0.714233709501274 0.780028075617613 0.928643105472669 GO:0016875 ligase activity, forming carbon-oxygen bonds 2/1273 41/18639 0.0487804878048781 0.714233709501274 0.780028075617613 0.928643105472669 GO:0061650 ubiquitin-like protein conjugating enzyme activity 2/1273 41/18639 0.0487804878048781 0.714233709501274 0.780028075617613 0.928643105472669 GO:0008194 UDP-glycosyltransferase activity 8/1273 145/18639 0.0551724137931034 0.807822954194545 0.781469172197868 0.929401608087176 GO:0005543 phospholipid binding 30/1273 497/18639 0.0603621730382294 0.883810324634373 0.785913188168192 0.930080601804849 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 3/1273 60/18639 0.05 0.732089552238806 0.786622505321384 0.930080601804849 GO:0004407 histone deacetylase activity 1/1273 22/18639 0.0454545454545455 0.665535956580733 0.789281202742696 0.930080601804849 GO:0005243 gap junction channel activity 1/1273 22/18639 0.0454545454545455 0.665535956580733 0.789281202742696 0.930080601804849 GO:0008093 cytoskeletal anchor activity 1/1273 22/18639 0.0454545454545455 0.665535956580733 0.789281202742696 0.930080601804849 GO:0016881 acid-amino acid ligase activity 1/1273 22/18639 0.0454545454545455 0.665535956580733 0.789281202742696 0.930080601804849 GO:0033558 protein lysine deacetylase activity 1/1273 22/18639 0.0454545454545455 0.665535956580733 0.789281202742696 0.930080601804849 GO:0033691 sialic acid binding 1/1273 22/18639 0.0454545454545455 0.665535956580733 0.789281202742696 0.930080601804849 GO:0050321 tau-protein kinase activity 1/1273 22/18639 0.0454545454545455 0.665535956580733 0.789281202742696 0.930080601804849 GO:0015085 calcium ion transmembrane transporter activity 8/1273 147/18639 0.054421768707483 0.796832165702102 0.793937258088052 0.934614531924428 GO:0030594 neurotransmitter receptor activity 5/1273 97/18639 0.0515463917525773 0.754731497153408 0.80050546431937 0.940349614969631 GO:0015103 inorganic anion transmembrane transporter activity 9/1273 165/18639 0.0545454545454545 0.798643147896879 0.801704722718956 0.940349614969631 GO:0003887 DNA-directed DNA polymerase activity 1/1273 23/18639 0.0434782608695652 0.63659961064244 0.803689809333906 0.940349614969631 GO:0043274 phospholipase binding 1/1273 23/18639 0.0434782608695652 0.63659961064244 0.803689809333906 0.940349614969631 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 1/1273 23/18639 0.0434782608695652 0.63659961064244 0.803689809333906 0.940349614969631 GO:0140103 catalytic activity, acting on a glycoprotein 1/1273 23/18639 0.0434782608695652 0.63659961064244 0.803689809333906 0.940349614969631 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 9/1273 167/18639 0.0538922155688623 0.789078559299312 0.812736147594411 0.942698271910696 GO:0022824 transmitter-gated monoatomic ion channel activity 3/1273 63/18639 0.0476190476190476 0.697228144989339 0.813569994099248 0.942698271910696 GO:0022835 transmitter-gated channel activity 3/1273 63/18639 0.0476190476190476 0.697228144989339 0.813569994099248 0.942698271910696 GO:1901682 sulfur compound transmembrane transporter activity 3/1273 63/18639 0.0476190476190476 0.697228144989339 0.813569994099248 0.942698271910696 GO:0004806 triacylglycerol lipase activity 1/1273 24/18639 0.0416666666666667 0.610074626865672 0.81711390004716 0.942698271910696 GO:0005540 hyaluronic acid binding 1/1273 24/18639 0.0416666666666667 0.610074626865672 0.81711390004716 0.942698271910696 GO:0019957 C-C chemokine binding 1/1273 24/18639 0.0416666666666667 0.610074626865672 0.81711390004716 0.942698271910696 GO:0030215 semaphorin receptor binding 1/1273 24/18639 0.0416666666666667 0.610074626865672 0.81711390004716 0.942698271910696 GO:0030552 cAMP binding 1/1273 24/18639 0.0416666666666667 0.610074626865672 0.81711390004716 0.942698271910696 GO:0042625 ATPase-coupled ion transmembrane transporter activity 1/1273 24/18639 0.0416666666666667 0.610074626865672 0.81711390004716 0.942698271910696 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 1/1273 24/18639 0.0416666666666667 0.610074626865672 0.81711390004716 0.942698271910696 GO:0046961 proton-transporting ATPase activity, rotational mechanism 1/1273 24/18639 0.0416666666666667 0.610074626865672 0.81711390004716 0.942698271910696 GO:0060229 lipase activator activity 1/1273 24/18639 0.0416666666666667 0.610074626865672 0.81711390004716 0.942698271910696 GO:0070840 dynein complex binding 1/1273 24/18639 0.0416666666666667 0.610074626865672 0.81711390004716 0.942698271910696 GO:1901981 phosphatidylinositol phosphate binding 10/1273 185/18639 0.0540540540540541 0.791448164582493 0.819447280455057 0.944447713066846 GO:0004715 non-membrane spanning protein tyrosine kinase activity 2/1273 45/18639 0.0444444444444444 0.650746268656716 0.82218790699953 0.94634750066033 GO:0046906 tetrapyrrole binding 8/1273 152/18639 0.0526315789473684 0.770620581304006 0.822769766480577 0.94634750066033 GO:0000030 mannosyltransferase activity 1/1273 25/18639 0.04 0.585671641791045 0.829620695923602 0.94634750066033 GO:0008139 nuclear localization sequence binding 1/1273 25/18639 0.04 0.585671641791045 0.829620695923602 0.94634750066033 GO:0008483 transaminase activity 1/1273 25/18639 0.04 0.585671641791045 0.829620695923602 0.94634750066033 GO:0015645 fatty acid ligase activity 1/1273 25/18639 0.04 0.585671641791045 0.829620695923602 0.94634750066033 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 1/1273 25/18639 0.04 0.585671641791045 0.829620695923602 0.94634750066033 GO:0017056 structural constituent of nuclear pore 1/1273 25/18639 0.04 0.585671641791045 0.829620695923602 0.94634750066033 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 1/1273 25/18639 0.04 0.585671641791045 0.829620695923602 0.94634750066033 GO:0120515 fatty acid-CoA ligase activity 1/1273 25/18639 0.04 0.585671641791045 0.829620695923602 0.94634750066033 GO:0005096 GTPase activator activity 15/1273 271/18639 0.0553505535055351 0.810431238640745 0.834481344845934 0.94634750066033 GO:0099095 ligand-gated monoatomic anion channel activity 2/1273 47/18639 0.0425531914893617 0.62305493807558 0.840422382562966 0.94634750066033 GO:0004529 DNA exonuclease activity 1/1273 26/18639 0.0384615384615385 0.563145809414466 0.841272831632705 0.94634750066033 GO:0008157 protein phosphatase 1 binding 1/1273 26/18639 0.0384615384615385 0.563145809414466 0.841272831632705 0.94634750066033 GO:0008198 ferrous iron binding 1/1273 26/18639 0.0384615384615385 0.563145809414466 0.841272831632705 0.94634750066033 GO:0019865 immunoglobulin binding 1/1273 26/18639 0.0384615384615385 0.563145809414466 0.841272831632705 0.94634750066033 GO:0034237 protein kinase A regulatory subunit binding 1/1273 26/18639 0.0384615384615385 0.563145809414466 0.841272831632705 0.94634750066033 GO:0015108 chloride transmembrane transporter activity 6/1273 121/18639 0.0495867768595041 0.726039225360799 0.842091282482634 0.94634750066033 GO:0008528 G protein-coupled peptide receptor activity 6/1273 122/18639 0.0491803278688525 0.720088084169317 0.847599892542121 0.94634750066033 GO:0008188 neuropeptide receptor activity 2/1273 48/18639 0.0416666666666667 0.610074626865672 0.848889150942407 0.94634750066033 GO:0030145 manganese ion binding 3/1273 68/18639 0.0441176470588235 0.645961369622476 0.85205614744047 0.94634750066033 GO:0140223 general transcription initiation factor activity 3/1273 68/18639 0.0441176470588235 0.645961369622476 0.85205614744047 0.94634750066033 GO:0015252 proton channel activity 1/1273 27/18639 0.037037037037037 0.54228855721393 0.852128668162634 0.94634750066033 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 1/1273 27/18639 0.037037037037037 0.54228855721393 0.852128668162634 0.94634750066033 GO:0035255 ionotropic glutamate receptor binding 1/1273 27/18639 0.037037037037037 0.54228855721393 0.852128668162634 0.94634750066033 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 1/1273 27/18639 0.037037037037037 0.54228855721393 0.852128668162634 0.94634750066033 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 13/1273 243/18639 0.0534979423868313 0.783305693753455 0.854200059908196 0.94634750066033 GO:0005267 potassium channel activity 6/1273 124/18639 0.0483870967741935 0.708473760231103 0.858146948676507 0.94634750066033 GO:0020037 heme binding 7/1273 142/18639 0.0492957746478873 0.721778431784738 0.859808527094906 0.94634750066033 GO:0004676 3-phosphoinositide-dependent protein kinase activity 13/1273 245/18639 0.0530612244897959 0.776911361559549 0.861677682910682 0.94634750066033 GO:0004711 ribosomal protein S6 kinase activity 13/1273 245/18639 0.0530612244897959 0.776911361559549 0.861677682910682 0.94634750066033 GO:0035175 histone H3S10 kinase activity 13/1273 245/18639 0.0530612244897959 0.776911361559549 0.861677682910682 0.94634750066033 GO:0035979 histone H2AXS139 kinase activity 13/1273 245/18639 0.0530612244897959 0.776911361559549 0.861677682910682 0.94634750066033 GO:0044022 histone H3S28 kinase activity 13/1273 245/18639 0.0530612244897959 0.776911361559549 0.861677682910682 0.94634750066033 GO:0044023 histone H4S1 kinase activity 13/1273 245/18639 0.0530612244897959 0.776911361559549 0.861677682910682 0.94634750066033 GO:0044024 histone H2AS1 kinase activity 13/1273 245/18639 0.0530612244897959 0.776911361559549 0.861677682910682 0.94634750066033 GO:0044025 histone H2BS14 kinase activity 13/1273 245/18639 0.0530612244897959 0.776911361559549 0.861677682910682 0.94634750066033 GO:0072354 histone H3T3 kinase activity 13/1273 245/18639 0.0530612244897959 0.776911361559549 0.861677682910682 0.94634750066033 GO:0072371 histone H2AS121 kinase activity 13/1273 245/18639 0.0530612244897959 0.776911361559549 0.861677682910682 0.94634750066033 GO:0072518 Rho-dependent protein serine/threonine kinase activity 13/1273 245/18639 0.0530612244897959 0.776911361559549 0.861677682910682 0.94634750066033 GO:0140823 histone H2BS36 kinase activity 13/1273 245/18639 0.0530612244897959 0.776911361559549 0.861677682910682 0.94634750066033 GO:0140855 histone H3S57 kinase activity 13/1273 245/18639 0.0530612244897959 0.776911361559549 0.861677682910682 0.94634750066033 GO:0140995 histone H2A kinase activity 13/1273 245/18639 0.0530612244897959 0.776911361559549 0.861677682910682 0.94634750066033 GO:0140997 histone H4 kinase activity 13/1273 245/18639 0.0530612244897959 0.776911361559549 0.861677682910682 0.94634750066033 GO:0140998 histone H2B kinase activity 13/1273 245/18639 0.0530612244897959 0.776911361559549 0.861677682910682 0.94634750066033 GO:1990244 histone H2AT120 kinase activity 13/1273 245/18639 0.0530612244897959 0.776911361559549 0.861677682910682 0.94634750066033 GO:0016866 intramolecular transferase activity 1/1273 28/18639 0.0357142857142857 0.522921108742004 0.862242584207604 0.94634750066033 GO:0045499 chemorepellent activity 1/1273 28/18639 0.0357142857142857 0.522921108742004 0.862242584207604 0.94634750066033 GO:0046875 ephrin receptor binding 1/1273 28/18639 0.0357142857142857 0.522921108742004 0.862242584207604 0.94634750066033 GO:0051537 2 iron, 2 sulfur cluster binding 1/1273 28/18639 0.0357142857142857 0.522921108742004 0.862242584207604 0.94634750066033 GO:0022843 voltage-gated monoatomic cation channel activity 7/1273 143/18639 0.048951048951049 0.716731030163866 0.864510460894924 0.94634750066033 GO:0048020 CCR chemokine receptor binding 2/1273 50/18639 0.04 0.585671641791045 0.864606240076604 0.94634750066033 GO:0004677 DNA-dependent protein kinase activity 13/1273 246/18639 0.0528455284552846 0.773753185293047 0.865302169721426 0.94634750066033 GO:0140857 histone H3T45 kinase activity 13/1273 246/18639 0.0528455284552846 0.773753185293047 0.865302169721426 0.94634750066033 GO:0035403 histone H3T6 kinase activity 13/1273 247/18639 0.0526315789473684 0.770620581304006 0.86885150166302 0.9477532293111 GO:0003785 actin monomer binding 1/1273 29/18639 0.0344827586206897 0.50488934637159 0.871665247702511 0.9477532293111 GO:0004181 metallocarboxypeptidase activity 1/1273 29/18639 0.0344827586206897 0.50488934637159 0.871665247702511 0.9477532293111 GO:0035250 UDP-galactosyltransferase activity 1/1273 29/18639 0.0344827586206897 0.50488934637159 0.871665247702511 0.9477532293111 GO:0099604 ligand-gated calcium channel activity 1/1273 29/18639 0.0344827586206897 0.50488934637159 0.871665247702511 0.9477532293111 GO:0106222 lncRNA binding 1/1273 29/18639 0.0344827586206897 0.50488934637159 0.871665247702511 0.9477532293111 GO:0004679 AMP-activated protein kinase activity 13/1273 248/18639 0.0524193548387097 0.767513240250361 0.872326501718867 0.9477532293111 GO:0001653 peptide receptor activity 6/1273 128/18639 0.046875 0.686333955223881 0.877437437158118 0.95241096465238 GO:0031210 phosphatidylcholine binding 1/1273 30/18639 0.0333333333333333 0.488059701492537 0.880443868856444 0.953882954449906 GO:0070566 adenylyltransferase activity 1/1273 30/18639 0.0333333333333333 0.488059701492537 0.880443868856444 0.953882954449906 GO:0046873 metal ion transmembrane transporter activity 25/1273 450/18639 0.0555555555555556 0.813432835820896 0.883298911382134 0.954761425339239 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 3/1273 73/18639 0.0410958904109589 0.601717440196279 0.883421264422589 0.954761425339239 GO:0015631 tubulin binding 21/1273 385/18639 0.0545454545454545 0.798643147896879 0.884332011826993 0.954761425339239 GO:0016251 RNA polymerase II general transcription initiation factor activity 2/1273 53/18639 0.0377358490566038 0.552520416784005 0.885384297546422 0.954761425339239 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 2/1273 53/18639 0.0377358490566038 0.552520416784005 0.885384297546422 0.954761425339239 GO:0005184 neuropeptide hormone activity 1/1273 31/18639 0.032258064516129 0.472315840154068 0.888622435944721 0.955913036280862 GO:0070273 phosphatidylinositol-4-phosphate binding 1/1273 31/18639 0.032258064516129 0.472315840154068 0.888622435944721 0.955913036280862 GO:0031491 nucleosome binding 3/1273 74/18639 0.0405405405405405 0.59358612343687 0.888932970589902 0.955913036280862 GO:0008509 monoatomic anion transmembrane transporter activity 7/1273 149/18639 0.0469798657718121 0.687869377942502 0.89007092383797 0.956247200703247 GO:0008378 galactosyltransferase activity 1/1273 32/18639 0.03125 0.457555970149254 0.896241935033413 0.960199885911608 GO:0042910 xenobiotic transmembrane transporter activity 1/1273 32/18639 0.03125 0.457555970149254 0.896241935033413 0.960199885911608 GO:0160041 neuropeptide activity 1/1273 32/18639 0.03125 0.457555970149254 0.896241935033413 0.960199885911608 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 2/1273 56/18639 0.0357142857142857 0.522921108742004 0.903173674406002 0.965750504389013 GO:0019239 deaminase activity 1/1273 33/18639 0.0303030303030303 0.443690637720489 0.903340554730434 0.965750504389013 GO:0008017 microtubule binding 14/1273 276/18639 0.0507246376811594 0.742699545749513 0.905524142217115 0.965750504389013 GO:0106310 protein serine kinase activity 19/1273 361/18639 0.0526315789473684 0.770620581304006 0.906754807116971 0.965750504389013 GO:0016779 nucleotidyltransferase activity 6/1273 136/18639 0.0441176470588235 0.645961369622476 0.90945004228984 0.965750504389013 GO:0015020 glucuronosyltransferase activity 1/1273 34/18639 0.0294117647058824 0.430640913081651 0.909953876982834 0.965750504389013 GO:0016831 carboxy-lyase activity 1/1273 34/18639 0.0294117647058824 0.430640913081651 0.909953876982834 0.965750504389013 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 1/1273 34/18639 0.0294117647058824 0.430640913081651 0.909953876982834 0.965750504389013 GO:0051427 hormone receptor binding 1/1273 34/18639 0.0294117647058824 0.430640913081651 0.909953876982834 0.965750504389013 GO:0052866 phosphatidylinositol phosphate phosphatase activity 1/1273 34/18639 0.0294117647058824 0.430640913081651 0.909953876982834 0.965750504389013 GO:0005244 voltage-gated monoatomic ion channel activity 8/1273 173/18639 0.046242774566474 0.677077042533 0.910996965250454 0.965750504389013 GO:0004386 helicase activity 7/1273 155/18639 0.0451612903225806 0.661242176215696 0.911447924124925 0.965750504389013 GO:0015370 solute:sodium symporter activity 3/1273 79/18639 0.0379746835443038 0.556017381447194 0.913134771049804 0.966651827228547 GO:0034061 DNA polymerase activity 1/1273 35/18639 0.0285714285714286 0.418336886993603 0.916115054870544 0.968028065971394 GO:0140566 histone reader activity 1/1273 35/18639 0.0285714285714286 0.418336886993603 0.916115054870544 0.968028065971394 GO:0022832 voltage-gated channel activity 8/1273 175/18639 0.0457142857142857 0.669339019189765 0.917008404250165 0.968028065971394 GO:0004674 protein serine/threonine kinase activity 23/1273 433/18639 0.0531177829099307 0.777739478128986 0.917784394727204 0.968028065971394 GO:0042393 histone binding 12/1273 247/18639 0.048582995951417 0.711342075049852 0.919535245538622 0.968990650722559 GO:0045505 dynein intermediate chain binding 1/1273 36/18639 0.0277777777777778 0.406716417910448 0.921854978282165 0.970550414293427 GO:0015079 potassium ion transmembrane transporter activity 7/1273 160/18639 0.04375 0.640578358208955 0.926433582412645 0.974483367851699 GO:0005254 chloride channel activity 3/1273 83/18639 0.036144578313253 0.529221363064197 0.928928665625806 0.976219579512211 GO:0000146 microfilament motor activity 1/1273 38/18639 0.0263157894736842 0.385310290652003 0.932184221050324 0.978712393591997 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 8/1273 181/18639 0.0441988950276243 0.647150985404469 0.932993994583374 0.978712393591997 GO:0015081 sodium ion transmembrane transporter activity 7/1273 164/18639 0.0426829268292683 0.624954495813615 0.936779935406406 0.980951173090671 GO:0000217 DNA secondary structure binding 1/1273 39/18639 0.0256410256410256 0.375430539609644 0.936825341775174 0.980951173090671 GO:0050997 quaternary ammonium group binding 1/1273 40/18639 0.025 0.366044776119403 0.941149069727873 0.984586719099929 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 1/1273 41/18639 0.024390243902439 0.357116854750637 0.945177094580629 0.987014201748155 GO:0042169 SH2 domain binding 1/1273 41/18639 0.024390243902439 0.357116854750637 0.945177094580629 0.987014201748155 GO:0042054 histone methyltransferase activity 2/1273 67/18639 0.0298507462686567 0.437068389396302 0.94861350063075 0.988123631641949 GO:0004402 histone acetyltransferase activity 1/1273 42/18639 0.0238095238095238 0.34861407249467 0.948929624884902 0.988123631641949 GO:0019894 kinesin binding 1/1273 42/18639 0.0238095238095238 0.34861407249467 0.948929624884902 0.988123631641949 GO:0005262 calcium channel activity 5/1273 131/18639 0.0381679389312977 0.558846986441837 0.94965861137907 0.988123631641949 GO:0004712 protein serine/threonine/tyrosine kinase activity 1/1273 43/18639 0.0232558139534884 0.340506768483166 0.952425489138358 0.988333810990971 GO:0005245 voltage-gated calcium channel activity 1/1273 43/18639 0.0232558139534884 0.340506768483166 0.952425489138358 0.988333810990971 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1/1273 43/18639 0.0232558139534884 0.340506768483166 0.952425489138358 0.988333810990971 GO:0098960 postsynaptic neurotransmitter receptor activity 2/1273 69/18639 0.0289855072463768 0.424399740428293 0.954305889692182 0.98939695828176 GO:0035091 phosphatidylinositol binding 13/1273 284/18639 0.0457746478873239 0.6702228295144 0.955792577225509 0.990050375692373 GO:0016278 lysine N-methyltransferase activity 2/1273 70/18639 0.0285714285714286 0.418336886993603 0.956920853056008 0.990331697522601 GO:0140299 molecular sensor activity 2/1273 71/18639 0.028169014084507 0.412444818162708 0.959392132942559 0.99062288130909 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 1/1273 46/18639 0.0217391304347826 0.31829980532122 0.961542602934417 0.99062288130909 GO:0008276 protein methyltransferase activity 3/1273 95/18639 0.0315789473684211 0.462372348782404 0.961803876152328 0.99062288130909 GO:0061749 forked DNA-dependent helicase activity 1/1273 47/18639 0.0212765957446809 0.31152746903779 0.964175651203362 0.99062288130909 GO:0140938 histone H3 methyltransferase activity 1/1273 47/18639 0.0212765957446809 0.31152746903779 0.964175651203362 0.99062288130909 GO:1990518 single-stranded 3'-5' DNA helicase activity 1/1273 47/18639 0.0212765957446809 0.31152746903779 0.964175651203362 0.99062288130909 GO:0009378 four-way junction helicase activity 1/1273 48/18639 0.0208333333333333 0.305037313432836 0.966628555464233 0.99062288130909 GO:0032266 phosphatidylinositol-3-phosphate binding 1/1273 48/18639 0.0208333333333333 0.305037313432836 0.966628555464233 0.99062288130909 GO:0036121 double-stranded DNA helicase activity 1/1273 48/18639 0.0208333333333333 0.305037313432836 0.966628555464233 0.99062288130909 GO:0038187 pattern recognition receptor activity 1/1273 48/18639 0.0208333333333333 0.305037313432836 0.966628555464233 0.99062288130909 GO:0043138 3'-5' DNA helicase activity 1/1273 48/18639 0.0208333333333333 0.305037313432836 0.966628555464233 0.99062288130909 GO:0005253 monoatomic anion channel activity 3/1273 103/18639 0.029126213592233 0.426459933342994 0.975094420251407 0.998413773082928 GO:0004843 cysteine-type deubiquitinase activity 3/1273 108/18639 0.0277777777777778 0.406716417910448 0.98102743086434 0.999999979449485 GO:0017116 single-stranded DNA helicase activity 1/1273 58/18639 0.0172413793103448 0.252444673185795 0.983584748129241 0.999999979449485 GO:0019905 syntaxin binding 1/1273 61/18639 0.0163934426229508 0.240029361389772 0.986732906108183 0.999999979449485 GO:0101005 deubiquitinase activity 3/1273 115/18639 0.0260869565217391 0.381959766385464 0.98711004695715 0.999999979449485 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 3/1273 122/18639 0.0245901639344262 0.360044042084659 0.991294577978149 0.999999979449485 GO:0016279 protein-lysine N-methyltransferase activity 1/1273 69/18639 0.0144927536231884 0.212199870214147 0.992481887857472 0.999999979449485 GO:0022836 gated channel activity 12/1273 318/18639 0.0377358490566038 0.552520416784005 0.993147772834254 0.999999979449485 GO:0019783 ubiquitin-like protein peptidase activity 3/1273 127/18639 0.0236220472440945 0.345869079797861 0.993444818699671 0.999999979449485 GO:0005261 monoatomic cation channel activity 13/1273 341/18639 0.0381231671554252 0.558191447454808 0.99400557821227 0.999999979449485 GO:0003774 cytoskeletal motor activity 4/1273 153/18639 0.0261437908496732 0.382791922739245 0.99406353618826 0.999999979449485 GO:0003678 DNA helicase activity 1/1273 74/18639 0.0135135135135135 0.197862041145623 0.994729085238937 0.999999979449485 GO:0000149 SNARE binding 2/1273 106/18639 0.0188679245283019 0.276260208392002 0.995222668341984 0.999999979449485 GO:0140767 enzyme-substrate adaptor activity 3/1273 139/18639 0.0215827338129496 0.316009878664233 0.99671548111626 0.999999979449485 GO:0140030 modification-dependent protein binding 4/1273 173/18639 0.023121387283237 0.3385385212665 0.997998106389883 0.999999979449485 GO:0005216 monoatomic ion channel activity 17/1273 448/18639 0.0379464285714286 0.55560367803838 0.998004569818946 0.999999979449485 GO:0005179 hormone activity 2/1273 132/18639 0.0151515151515152 0.221845318860244 0.999085581152152 0.999999979449485 GO:0022834 ligand-gated channel activity 4/1273 188/18639 0.0212765957446809 0.31152746903779 0.999134714664191 0.999999979449485 GO:0004497 monooxygenase activity 1/1273 106/18639 0.00943396226415094 0.138130104196001 0.999458199319647 0.999999979449485 GO:0015276 ligand-gated monoatomic ion channel activity 3/1273 186/18639 0.0161290322580645 0.236157920077034 0.999803207535371 0.999999979449485 GO:0061630 ubiquitin protein ligase activity 9/1273 353/18639 0.0254957507082153 0.373303454399391 0.999916213463011 0.999999979449485 GO:0099094 ligand-gated monoatomic cation channel activity 1/1273 136/18639 0.00735294117647059 0.107660228270413 0.999936035521386 0.999999979449485 GO:0061659 ubiquitin-like protein ligase activity 9/1273 372/18639 0.0241935483870968 0.354236880115551 0.999967916305689 0.999999979449485 GO:0016755 aminoacyltransferase activity 14/1273 496/18639 0.0282258064516129 0.41327636013481 0.999980446602072 0.999999979449485 GO:0004842 ubiquitin-protein transferase activity 11/1273 449/18639 0.0244988864142539 0.35870757570721 0.999992954237428 0.999999979449485 GO:0019787 ubiquitin-like protein transferase activity 12/1273 479/18639 0.0250521920668058 0.366808961455769 0.999994958920249 0.999999979449485 GO:0045182 translation regulator activity 6/1273 356/18639 0.0168539325842697 0.24677175918162 0.999998816035894 0.999999979449485 GO:0030371 translation repressor activity 3/1273 329/18639 0.00911854103343465 0.133511772444767 0.999999979449485 0.999999979449485