category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	6/57	122/9376	8.08973252804141	MAPK10/PIK3R1/MAP3K1/JUNB/ITPR2/SOS2	6.16429520849026
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	4/57	70/9376	9.39949874686717	HGF/PIK3R1/TGFB2/SOS2	5.51644478631557
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	6/57	204/9376	4.83797729618163	HGF/PIK3R1/TGFB2/ITPR2/SOS2/WNT5A	4.3343489456743
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	5/57	142/9376	5.79194465035829	MAPK10/PIK3R1/JUNB/TGFB2/ITPR2	4.49986453968645
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	4/57	87/9376	7.56281508368623	MAPK10/PIK3R1/TGFB2/SOS2	4.80954201108954
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	5/57	150/9376	5.48304093567251	HGF/PIK3R1/TGFB2/SOS2/WNT5A	4.32862555517106
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	4/57	93/9376	7.07489152990002	MAPK10/MAP3K1/ITPR2/SOS2	4.60441263526614
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	5/57	163/9376	5.04574319233667	MAPK10/PIK3R1/MAP3K1/TGFB2/SOS2	4.07502229170867
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	5/57	170/9376	4.83797729618163	HGF/PIK3R1/TGFB2/SOS2/WNT5A	3.94938786024837
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	5/57	184/9376	4.4698703279939	LRRC4C/EPHA7/PIK3R1/WNT5A/EPHA5	3.7175392196017
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	4/57	120/9376	5.48304093567251	MAPK10/PIK3R1/MAP3K1/SOS2	3.86536103801801
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	6/57	275/9376	3.5888995215311	TUBB2B/STIP1/MT-CO3/MAPK10/PIK3R1/ITPR2	3.4078101738165
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	3/57	68/9376	7.25696594427245	RUNX1T1/PIK3R1/SOS2	4.04975239009662
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	3/57	69/9376	7.15179252479024	MAPK10/PIK3R1/SOS2	4.01106572742064
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	4/57	133/9376	4.9471046036143	MAPK10/PIK3R1/TGFB2/SOS2	3.58538989445316
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	3/57	71/9376	6.95033358042995	MAPK10/PIK3R1/SOS2	3.93596029839819
NA	NA	hsa04517	IgSF CAM signaling	6/57	299/9376	3.30082731913396	TUBB2B/LRRC4C/MAPK10/MPDZ/PIK3R1/NLGN1	3.16218199831165
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	6/57	300/9376	3.28982456140351	HGF/MAPK10/MAP3K1/TGFB2/SOS2/MAP3K20	3.1524920741698
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	3/57	73/9376	6.75991348233598	HGF/PIK3R1/SOS2	3.86370793495175
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	4/57	142/9376	4.63355572028663	MAP3K1/NEDD4/PIAS2/HERC4	3.41208209436855
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	3/57	77/9376	6.40874914559125	MAPK10/PIK3R1/TGFB2	3.72702656698346
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	3/57	77/9376	6.40874914559125	PIK3R1/TGFB2/SOS2	3.72702656698346
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	5/57	224/9376	3.67167919799499	MAPK10/HLA-DQA2/PIK3R1/MAP3K1/TGFB2	3.16510937733093
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	5/57	227/9376	3.62315480330783	HGF/MT-CO3/MAPK10/PIK3R1/SOS2	3.12887667588586
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	3/57	80/9376	6.16842105263158	HGF/PIK3R1/SOS2	3.63072397459789
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	4/57	157/9376	4.19085931388982	PIK3R1/TGFB2/ITPR2/HIPK3	3.15321791473943
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	3/57	86/9376	5.73806609547124	MAPK10/PIK3R1/SOS2	3.45208033298949
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	4/57	158/9376	4.16433488785254	FNIP1/PIK3R1/SOS2/WNT5A	3.13711934818889
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	3/57	89/9376	5.54464813719692	TUBB2B/ITPR2/SOS2	3.36896077857125
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	3/57	91/9376	5.42278773857721	PIK3R1/IFITM1/SOS2	3.31561617166119
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	4/57	170/9376	3.8703818369453	MAPK10/MPDZ/MAP3K1/NEDD4	2.95370459652993
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	3/57	98/9376	5.03544575725027	PIK3R1/ITPR2/PIKFYVE	3.1406227912642
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	3/57	99/9376	4.9845826687932	MAPK10/PIK3R1/SOS2	3.11698757296619
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	3/57	99/9376	4.9845826687932	MAPK10/PIK3R1/ITPR2	3.11698757296619
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	3/57	99/9376	4.9845826687932	MAPK10/PIK3R1/SOS2	3.11698757296619
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	4/57	178/9376	3.69643209146462	WIF1/MAPK10/CHD8/WNT5A	2.84047646953059
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	5/57	268/9376	3.06886619533909	TUBB2B/MT-CO3/MAPK10/ITPR2/SLC18A2	2.68736526597024
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	3/57	101/9376	4.88587806149036	MAPK10/PIK3R1/TGFB2	3.07065699215454
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	3/57	103/9376	4.79100664282064	MAPK10/PIK3R1/TGFB2	3.02552982211221
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	3/57	105/9376	4.69974937343358	MAPK10/PIK3R1/ITPR2	2.98154984687514
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	6/57	388/9376	2.54367878459034	TUBB2B/MT-CO3/MAPK10/PIK3R1/ITPR2/WNT5A	2.4287324566772
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	3/57	112/9376	4.40601503759398	MAPK10/HLA-DQA2/TGFB2	2.83592479247885
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	2/57	47/9376	6.99962672639044	MAPK10/PIK3R1	3.22473494361202
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	4/57	203/9376	3.24120646443695	HGF/MAPK10/PIK3R1/SOS2	2.52471638659673
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	3/57	119/9376	4.1468376824414	MAPK10/PIK3R1/JUNB	2.70178695887098
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	4/57	205/9376	3.20958493795464	MAPK10/HLA-DQA2/PIK3R1/NEDD4	2.50159900081795
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	4/57	205/9376	3.20958493795464	MT-CO3/MAPK10/PIK3R1/TGFB2	2.50159900081795
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	2/57	50/9376	6.57964912280702	HGF/TGFB2	3.09373133341315
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	3/57	122/9376	4.04486626402071	MAPK10/PIK3R1/SOS2	2.64741362915445
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	3/57	130/9376	3.79595141700405	MAPK10/PIK3R1/SOS2	2.51051466445765
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	3/57	133/9376	3.71032845271072	MAPK10/ITPR2/SLC18A2	2.46195255025663
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	2/57	59/9376	5.5759738328873	PIK3R1/SOS2	2.75746431335382
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	3/57	137/9376	3.60199769496735	MAPK10/PIK3R1/ITPR2	2.39934731129994
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	3/57	138/9376	3.57589626239512	MAPK10/PIK3R1/SOS2	2.38406089039249
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/57	60/9376	5.48304093567251	GRID2/ITPR2	2.72440707830405
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	3/57	139/9376	3.55017039000379	PIK3R1/ITPR2/SOS2	2.36891532417509
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	4/57	238/9376	2.76455845496093	HGF/MAPK10/PIK3R1/SOS2	2.15643991436258
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	3/57	144/9376	3.42690058479532	TBX3/PIK3R1/WNT5A	2.29521696136306
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	3/57	144/9376	3.42690058479532	MAPK10/PIK3R1/ITPR2	2.29521696136306
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	2/57	65/9376	5.0612685560054	PIK3R1/ITPR2	2.5695592354327
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	3/57	148/9376	3.33428165007112	PIK3R1/SOS2/WNT5A	2.23855995736791
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	2/57	66/9376	4.9845826687932	HLA-DQA2/TGFB2	2.54049520228407
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	4/57	250/9376	2.63185964912281	ZFYVE16/RUFY2/NEDD4/RAB31	2.04527159130954
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	4/57	253/9376	2.60065182719645	MAPK10/FNBP1L/PIK3R1/ITPR2	2.01849049209179
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	2/57	70/9376	4.69974937343358	HLA-DQA2/SGCE	2.42984298906697
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	3/57	155/9376	3.18370118845501	TUBB2B/HLA-DQA2/PIKFYVE	2.14391942243537
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	3/57	157/9376	3.14314448541736	MT-CO3/MAPK10/PIK3R1	2.11786259452942
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	2/57	72/9376	4.5692007797271	MAPK10/MAP3K1	2.37761091990195
Human Diseases	Cancer: specific types	hsa05218	Melanoma	2/57	73/9376	4.50660898822398	HGF/PIK3R1	2.35220772223812
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	3/57	160/9376	3.08421052631579	LRRC4C/HLA-DQA2/NLGN1	2.07954706270767
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	2/57	75/9376	4.38643274853801	REV3L/PIK3R1	2.30274938513739
Human Diseases	Cancer: specific types	hsa05214	Glioma	2/57	76/9376	4.32871652816251	PIK3R1/SOS2	2.2786653294294
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	2/57	78/9376	4.21772379667116	ARHGAP10/PIK3R1	2.23171998702554
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	2/57	78/9376	4.21772379667116	HLA-DQA2/TGFB2	2.23171998702554
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	3/57	168/9376	2.93734335839599	PIK3R1/PIAS2/SOS2	1.98160456451993
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	3/57	169/9376	2.91996262846465	WDFY3/MAPK10/PIK3R1	1.96976976186545
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	2/57	83/9376	3.96364404988375	MBD5/LCOR	2.12092606337893
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	3/57	180/9376	2.74152046783626	HLA-DQA2/PIK3R1/HCFC2	1.84503141176523
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	3/57	181/9376	2.72637394591451	MAPK10/HLA-DQA2/TGFB2	1.83415782902274
NA	NA	hsa04519	Cadherin signaling	5/57	404/9376	2.03578252562098	MAPK10/PCDHB3/MPDZ/WNT5A/PCDH10	1.66438211432875
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	2/57	93/9376	3.53744576495001	MAPK10/HLA-DQA2	1.9232355481466
Organismal Systems	Digestive system	hsa04970	Salivary secretion	2/57	93/9376	3.53744576495001	SLC12A2/ITPR2	1.9232355481466
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	2/57	95/9376	3.46297322253001	HLA-DQA2/TGFB2	1.88695922944145
Cellular Processes	Cell motility	hsa04814	Motor proteins	3/57	194/9376	2.54367878459034	TUBB2B/KIF1B/KIF27	1.69913375015635
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	3/57	196/9376	2.51772287862513	MAPK10/PIK3R1/ITPR2	1.6793359537619
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	2/57	99/9376	3.3230551125288	TGFB2/SGCE	1.81723771821276
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	2/57	102/9376	3.22531819745442	SLC12A2/ITPR2	1.76724625348057
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	2/57	103/9376	3.1940044285471	PIK3R1/TGFB2	1.75099292980309
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/57	23/9376	7.15179252479024	LNPEP	2.31008808995591
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	2/57	105/9376	3.13316624895572	TGFB2/SGCE	1.71907360768888
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	2/57	106/9376	3.10360807679576	PIK3R1/SOS2	1.70339867600199
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	3/57	214/9376	2.30595179537629	MAPK10/PIK3R1/ITPR2	1.51139262918398
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	2/57	109/9376	3.01818767101239	MAPK10/PIK3R1	1.65746217597319
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	2/57	109/9376	3.01818767101239	MAPK10/HLA-DQA2	1.65746217597319
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	2/57	109/9376	3.01818767101239	MAPK10/PIK3R1	1.65746217597319
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	3/57	216/9376	2.28460038986355	MAPK10/MIB1/PIK3R1	1.49377641583674
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	2/57	110/9376	2.99074960127592	ZFYVE16/TGFB2	1.64249948563816
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	2/57	110/9376	2.99074960127592	MAPK10/PIK3R1	1.64249948563816
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	2/57	115/9376	2.86071700991609	PIK3R1/ITPR2	1.57014122365223
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	2/57	115/9376	2.86071700991609	ITPR2/SLC18A2	1.57014122365223
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	3/57	227/9376	2.1738928819847	PIK3R1/ITPR2/SOS2	1.4002094172249
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	5/57	480/9376	1.71345029239766	TUBB2B/MT-CO3/MAPK10/ITPR2/WNT5A	1.25494693444639
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	3/57	232/9376	2.12704174228675	PIK3R1/SOS2/PIKFYVE	1.35942200395631
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	3/57	238/9376	2.0734188412207	MAPK10/PIK3R1/RPL26	1.31180875732926
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	2/57	125/9376	2.63185964912281	MAPK10/PIK3R1	1.43642144399067
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/57	32/9376	5.14035087719298	MAPK10	1.83478056729538
Human Diseases	Immune disease	hsa05310	Asthma	1/57	32/9376	5.14035087719298	HLA-DQA2	1.83478056729538
Organismal Systems	Immune system	hsa04611	Platelet activation	2/57	126/9376	2.61097187412977	PIK3R1/ITPR2	1.42377307104296
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	2/57	133/9376	2.47355230180715	PIK3R1/SOS2	1.3385152060601
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	3/57	250/9376	1.97389473684211	LAMP5/MFSD8/PIKFYVE	1.22061921149883
Human Diseases	Infectious disease: viral	hsa05162	Measles	2/57	136/9376	2.41898864809082	MAPK10/PIK3R1	1.303619354983
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	2/57	138/9376	2.38393084159675	MAPK10/PIK3R1	1.28086501099658
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/57	38/9376	4.32871652816251	PIK3R1	1.60797793919982
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/57	39/9376	4.21772379667116	HLA-DQA2	1.57476515529512
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	2/57	142/9376	2.31677786014332	MAPK10/PIK3R1	1.23651720373274
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	2/57	149/9376	2.20793594725068	PIK3R1/SOS2	1.16237213372474
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	2/57	149/9376	2.20793594725068	MAPK10/ITPR2	1.16237213372474
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	1/57	44/9376	3.7384370015949	HLA-DQA2	1.42390212345221
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/57	45/9376	3.65536062378168	HLA-DQA2	1.39638148958338
NA	NA	hsa04518	Integrin signaling	2/57	154/9376	2.13624971519708	HGF/PIK3R1	1.11188532679513
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	2/57	155/9376	2.12246745897001	ITPR2/WNT5A	1.10201881056816
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	2/57	156/9376	2.10886189833558	PIK3R1/SOS2	1.09222650099253
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	2/57	157/9376	2.09542965694491	TGFB2/WNT5A	1.08250727431941
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/57	48/9376	3.42690058479532	PIK3R1	1.31830757174214
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/57	49/9376	3.35696383816685	SLC18A2	1.29365473127502
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	1/57	50/9376	3.28982456140351	HLA-DQA2	1.26963216462421
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	1/57	51/9376	3.22531819745442	SLC12A2	1.24620990098248
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/57	54/9376	3.0461338531514	REV3L	1.17927415758399
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	1/57	54/9376	3.0461338531514	HLA-DQA2	1.17927415758399
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	2/57	173/9376	1.9016326944529	HLA-DQA2/PIK3R1	0.936108960079856
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	3/57	308/9376	1.60218728639781	TUBB2B/MT-CO3/MAPK10	0.840406872016023
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1/57	59/9376	2.78798691644365	PIK3R1	1.07743407084258
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	1/57	60/9376	2.74152046783626	PIK3R1	1.05834650132917
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	3/57	323/9376	1.52778230405736	PIK3R1/TGFB2/SOS2	0.754915314763445
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	2/57	187/9376	1.75926447133877	MAPK10/ITPR2	0.820196979989255
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	1/57	62/9376	2.65308432371251	PIK3R1	1.02131837504895
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	1/57	63/9376	2.61097187412977	SETD2	1.00334858279922
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	1/57	63/9376	2.61097187412977	WNT5A	1.00334858279922
Human Diseases	Substance dependence	hsa05034	Alcoholism	2/57	191/9376	1.72242123633692	SOS2/SLC18A2	0.788871048007572
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	1/57	65/9376	2.5306342780027	ITPR2	0.968430280065051
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	2/57	193/9376	1.70457231160804	PIK3R1/SOS2	0.773482237240964
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	3/57	333/9376	1.48190295558717	PIK3R1/SOS2/WNT5A	0.700267307415736
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	1/57	67/9376	2.45509295627128	ITPR2	0.934792102798864
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	2/57	200/9376	1.64491228070175	TUBB2B/MAPK10	0.720986864698886
Organismal Systems	Endocrine system	hsa04924	Renin secretion	1/57	69/9376	2.38393084159675	ITPR2	0.902344730495993
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	1/57	69/9376	2.38393084159675	SLC18A2	0.902344730495993
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	2/57	201/9376	1.63672863751418	HOXA11/RUNX1T1	0.713654133459586
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	1/57	70/9376	2.34987468671679	MAPK10	0.88654209044267
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	1/57	71/9376	2.31677786014332	MAPK10	0.871007534162366
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	1/57	71/9376	2.31677786014332	PIK3R1	0.871007534162366
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	1/57	75/9376	2.19321637426901	ITPR2	0.811378366621941
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	2/57	212/9376	1.55180403839788	HGF/PIK3R1	0.635548466164621
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	1/57	76/9376	2.16435826408126	ITPR2	0.797058801778219
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	3/57	362/9376	1.36318697295725	HGF/PIK3R1/SOS2	0.551142854385175
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	1/57	78/9376	2.10886189833558	PIKFYVE	0.769074481758418
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	1/57	78/9376	2.10886189833558	MAPK10	0.769074481758418
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	2/57	217/9376	1.51604818497858	PIK3R1/SOS2	0.601498436078539
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	1/57	79/9376	2.08216744392627	SLC18A2	0.755396563462858
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	1/57	82/9376	2.00599058622165	HLA-DQA2	0.715546594333484
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	2/57	226/9376	1.45567458469182	MAPK10/PIK3R1	0.542296609440121
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	1/57	86/9376	1.91268869849041	SGCE	0.664970610944415
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	1/57	87/9376	1.89070377092156	MT-CO3	0.652749948163542
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	2/57	233/9376	1.411941871847	SYNE1/SGCE	0.497975468509425
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	2/57	235/9376	1.39992534527809	MT-CO3/SOS2	0.485572871659087
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	1/57	90/9376	1.82768031189084	PIK3R1	0.617032372676085
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	1/57	90/9376	1.82768031189084	PIK3R1	0.617032372676085
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	1/57	93/9376	1.768722882475	PIK3R1	0.582647004586825
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	1/57	94/9376	1.74990668159761	MAPK10	0.571463870166745
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	2/57	248/9376	1.32654216185625	TUBB2B/MAPK10	0.407582659262169
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	1/57	98/9376	1.67848191908342	PIK3R1	0.528034796330908
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	1/57	98/9376	1.67848191908342	ITPR2	0.528034796330908
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	1/57	99/9376	1.6615275562644	HLA-DQA2	0.51748786345932
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	1/57	100/9376	1.64491228070175	HLA-DQA2	0.507059223742803
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	2/57	254/9376	1.2952065202376	HGF/ITPR2	0.373023489176778
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	1/57	101/9376	1.62862602049679	WNT5A	0.496746129122851
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	1/57	105/9376	1.56658312447786	MAPK10	0.456597368502624
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	1/57	107/9376	1.53730119691753	ITPR2	0.437151191014343
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	1/57	110/9376	1.49537480063796	PIK3R1	0.408716824418533
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	1/57	115/9376	1.43035850495805	ITPR2	0.363152282686147
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	1/57	116/9376	1.41802782819117	PIK3R1	0.354296698376653
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	1/57	116/9376	1.41802782819117	ITPR2	0.354296698376653
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	1/57	122/9376	1.34828875467357	PIK3R1	0.302825909597246
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	1/57	122/9376	1.34828875467357	PIK3R1	0.302825909597246
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	1/57	134/9376	1.22754647813564	ITPR2	0.207480815033441
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	1/57	138/9376	1.19196542079837	MT-CO3	0.177669131600664
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	1/57	138/9376	1.19196542079837	ITPR2	0.177669131600664
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	1/57	140/9376	1.1749373433584	ITPR2	0.163095880919899
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	1/57	143/9376	1.15028830818304	HLA-DQA2	0.141631614779232
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	1/57	144/9376	1.14230019493177	MAPK10	0.134578986489561
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	1/57	154/9376	1.06812485759854	ITPR2	0.0666640691220659
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	1/57	157/9376	1.04771482847246	GULP1	0.0471519541093937
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	1/57	158/9376	1.04108372196314	TGFB2	0.040730372616671
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	1/57	166/9376	0.990911012470936	ITPR2	-0.00924013138808204
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	1/57	168/9376	0.979114452798663	MAPK10	-0.0213627055252256
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	1/57	174/9376	0.945351885460778	MAPK10	-0.0569045642989847
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	2/57	368/9376	0.893974065598779	TUBB2B/MT-CO3	-0.162278221477641
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	1/57	195/9376	0.843544759334233	PIK3R1	-0.172663618091004
NA	NA	hsa04082	Neuroactive ligand signaling	1/57	199/9376	0.826589085779776	SLC18A2	-0.193370851824986
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	1/57	205/9376	0.802396234488661	PIK3R1	-0.223718660400815
NA	NA	hsa04081	Hormone signaling	1/57	219/9376	0.751101498037331	PIK3R1	-0.291478243173775
Genetic Information Processing	Translation	hsa03010	Ribosome	1/57	222/9376	0.740951477793583	RPL26	-0.305485472824642
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	1/57	298/9376	0.551983986812669	TGFB2	-0.614674207589717
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1/57	370/9376	0.44457088667615	GRID2	-0.852514826666992