category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
NA	NA	hsa04519	Cadherin signaling	94/1005	404/9376	2.17069109896064	VIM/LHFPL6/CDH4/LEF1/CDH11/PCDH18/WNT2/JUP/WNT5A/ACTR3B/DCHS2/PCDH10/AFDN/FAT1/MAPK10/MPDZ/AXIN2/EP300/FGFR1/PKP2/WNT16/FMN1/CDH6/ADAM10/PCDH9/VCL/ACTG1/GABRE/LATS2/VAV3/YWHAZ/EVL/AMOTL2/CDH2/PCDHB12/CTNNB1/PCDH19/CDH8/PCDHB11/FZD3/PCDHGA10/MRAS/PCDHB4/TAOK1/PCDHGA5/CTNNA1/NCKAP1/TEAD1/FAT4/PCDHB16/MOB1B/IGF1R/TAOK3/MYO1E/RAF1/ERBIN/PCDHGC3/PCDHGA8/PCDHB15/ACTR3/ACTR2/APC/DSG2/ARPC5/PCDHB2/PCDHA9/PCDHA10/PCDHB9/PCDH7/GSK3B/CREBBP/PCDHA4/PCDHA5/PCDHB13/CELSR2/YAP1/CTNND1/LATS1/TJP1/GABRQ/CDH10/NRAS/WASF1/SHOC2/PCDHB10/RRAS2/CSNK1A1/PCDHGA9/MAPK1/CHUK/ROCK1/PCDHA2/GABRA5/PCDHB7	8.33428532598866
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	45/1005	133/9376	3.1565480866345	GADD45G/PRKAA2/STAT3/TGFB2/SGK1/INSR/SMAD3/MAPK10/GADD45A/FOXO1/PIK3R1/SGK3/NLK/GADD45B/EP300/SETD7/HOMER2/KLF2/CCNG2/SOS2/BCL6/SOS1/IGF1R/FBXO32/RAF1/SIRT1/AKT3/MDM2/BCL2L11/STK4/BRAF/CSNK1E/FOXO3/CREBBP/PIK3CA/PLK2/NRAS/AGAP2/HOMER1/TGFB1/PIK3CD/MAPK1/CHUK/USP7/PRKAG2	8.67877618425103
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	56/1005	204/9376	2.56099892693396	HGF/CD44/ANK2/DDX5/SDC2/WNT2/STAT3/WNT5A/TWIST2/TGFB2/IQGAP1/FN1/PIK3R1/ANK1/CAV2/ITPR2/FGFR1/WNT16/HIF1A/ACTG1/ESR1/HCLS1/VAV3/CAMK2D/PTPN11/CTNNB1/SOS2/PAK1/FZD3/MRAS/ITGA5/SOS1/IGF1R/FRS2/RAF1/AKT3/ARHGEF12/MDM2/PRKCB/TWIST1/BRAF/ANK3/FGF2/PIK3CA/GAB1/CASP3/NRAS/CBL/RRAS2/THBS1/TGFB1/PIK3CD/HPSE2/MAPK1/ROCK1/VEGFA	7.81026308840751
NA	NA	hsa04517	IgSF CAM signaling	71/1005	299/9376	2.21533136990632	TUBB2B/ANK2/NLGN1/PTPRD/APP/ROBO2/EPB41L2/LRRC4C/NRCAM/ACTR3B/IQGAP1/AFDN/LYN/CADM1/MAPK10/FOXO1/PIK3R1/SLITRK6/MPDZ/TUBA1A/FGFR1/PRKCI/VCL/ACTG1/TUBB2A/MYH10/EPB41L3/VAV3/CLEC4M/PTPN11/NCAM1/CDH2/CTNNB1/PAK1/TUBB4A/ITGA5/ROBO3/SCN8A/NCAM2/NCK2/PARD6G/ACTR3/AKT3/ACTR2/KCNA4/PRKCB/ARPC5/FYN/ANK3/GSK3B/PIK3CA/RASA1/ABL1/TJP1/RAPGEF2/ERC1/SLIT3/TJP2/SLIT2/CADM2/KIRREL1/PAK2/PIK3CD/MAPK1/MYLK/LRRC4B/PMP22/SPTAN1/SSX2IP/JAM2/SRGAP2	7.40012630870863
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	68/1005	300/9376	2.11465339966832	RPS6KA2/HGF/FOS/GADD45G/MAP3K20/NTF3/MAP4K4/STMN1/JUND/HSPA1A/DUSP1/TGFB2/INSR/MAPK10/GADD45A/NR4A1/PPP3R1/NLK/JUN/GADD45B/MAP3K4/FGFR1/MEF2C/CACNA1B/CACNB4/HSPA1B/GNG12/PDGFC/SOS2/PAK1/DUSP8/DUSP16/PPM1A/MRAS/TAOK1/SOS1/HSPA8/IGF1R/TAOK3/RAF1/FGF18/AKT3/BDNF/NF1/PRKCB/FGF7/FGF10/STK4/BRAF/FGF2/ATF2/RASA1/PPP3CB/CASP3/RAPGEF2/MAP3K6/NRAS/RRAS2/TGFB1/PAK2/PLA2G4C/PPM1B/MAPK1/CHUK/MAP2K4/MAP3K12/DUSP5/VEGFA	6.79881504552393
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	35/1005	110/9376	2.96843057440072	FBN1/GREM1/ID4/TGFB2/ZFYVE16/SMAD3/FMOD/LTBP1/EP300/ID2/GREM2/LEMD3/SKIL/SP1/BMPR2/THSD4/TGIF1/SMAD7/NCOR1/SMAD9/SMURF2/PPP2R1B/ZFYVE9/NBL1/CREBBP/HDAC2/PPP2CA/ACVR2A/PPP2CB/SKI/THBS1/TGFB1/MAPK1/ROCK1/BAMBI	7.19532300813439
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	42/1005	148/9376	2.647519160952	FOS/PGR/GADD45G/HEY2/LEF1/WNT2/WNT5A/GADD45A/PIK3R1/AXIN2/NOTCH2/JUN/GADD45B/FGFR1/WNT16/SHC2/ESR1/SP1/NCOA1/CTNNB1/SOS2/FZD3/SOS1/IGF1R/RB1/RAF1/FGF18/AKT3/APC/FGF7/FGF10/BRAF/NCOA3/POLK/GSK3B/FGF2/PIK3CA/NRAS/CSNK1A1/PIK3CD/MAPK1/BRCA2	6.99983071518489
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	47/1005	184/9376	2.38304131516331	EPHA7/EPHA5/CXCL12/EPHB1/ROBO2/SEMA3E/LRRC4C/WNT5A/BOC/SEMA3C/PIK3R1/PPP3R1/EPHA3/NTNG1/SEMA6D/SEMA6A/GNAI1/CXCR4/CAMK2D/PTPN11/BMPR2/PAK1/FZD3/ROBO3/SEMA4F/RAF1/NCK2/PARD6G/ARHGEF12/LRRC4/FYN/GSK3B/PIK3CA/RASA1/ABL1/PPP3CB/SEMA6C/NRAS/SLIT3/SLIT2/EPHB6/PAK2/PIK3CD/SEMA3A/MAPK1/ROCK1/SRGAP2	6.56476305661491
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	25/1005	70/9376	3.3319118692253	HGF/TGFB2/PIK3R1/JUN/EP300/HIF1A/PTPN11/SOS2/PAK1/SOS1/RAF1/AKT3/BRAF/CREBBP/PIK3CA/GAB1/NRAS/CUL2/TGFB1/PAK2/PIK3CD/MAPK1/EPAS1/EGLN3/VEGFA	6.78515271658615
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	39/1005	144/9376	2.52669983416252	TBX3/WNT2/STAT3/ID4/WNT5A/SMAD3/PIK3R1/AXIN2/RIF1/FGFR1/PCGF5/WNT16/ID2/BMI1/SKIL/KAT6A/BMPR2/CTNNB1/FZD3/SMARCAD1/IL6ST/IGF1R/SMAD9/RAF1/AKT3/APC/REST/LIFR/GSK3B/FGF2/PIK3CA/ACVR2A/KLF4/JAK2/NRAS/PIK3CD/MAPK1/JARID2/LIF	6.39686233764388
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	28/1005	87/9376	3.0025504660605	FOS/GADD45G/LEF1/TGFB2/SMAD3/MAPK10/GADD45A/PIK3R1/AXIN2/JUN/GADD45B/PMAIP1/CTNNB1/SOS2/SOS1/RAF1/AKT3/APC/BCL2L11/BRAF/POLK/GSK3B/PIK3CA/CASP3/NRAS/TGFB1/PIK3CD/MAPK1	6.50187494991956
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	43/1005	170/9376	2.35977758267486	HGF/GADD45G/LEF1/WNT2/WNT5A/TGFB2/SMAD3/GADD45A/PIK3R1/GSTA1/AXIN2/GADD45B/WNT16/SHC2/ACTG1/PBRM1/NFE2L2/TXNRD1/CTNNB1/SOS2/FZD3/DPF3/GSTA4/SOS1/IGF1R/RB1/RAF1/SMARCC2/AKT3/APC/PRKCB/ARID2/BRAF/SMARCC1/POLK/GSK3B/PIK3CA/GAB1/NRAS/CSNK1A1/TGFB1/PIK3CD/MAPK1	6.1992171682584
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	68/1005	333/9376	1.90509315285435	LAMA3/LAMB1/LAMC1/HEY2/PPP2R3A/WNT2/WNT5A/LAMA4/FN1/FOXO1/PIK3R1/COL6A1/AXIN2/NOTCH2/UBE3A/EP300/WNT16/MAML3/PRKCI/CREB5/HES4/TNC/CTNNB1/SOS2/COL4A4/IFNAR1/FZD3/ITGA5/SOS1/RB1/RAF1/PPP2R5B/PARD6G/AKT3/ATP6V1D/APC/MDM2/MAML1/PPP2R1B/ITGB8/IRF1/ATP6V1C1/TNXB/IFNA13/GSK3B/CREBBP/HDAC2/HLA-E/PPP2CA/IRF9/PIK3CA/STAT2/PPP2CB/TSC1/CREB1/CASP3/NRAS/COL9A3/LAMA1/CSNK1A1/THBS1/PIK3CD/MAPK1/CHUK/DLG1/TBK1/PATJ/VEGFA	5.82692098377264
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	31/1005	106/9376	2.72839575706374	HSP90AA1/LEF1/FOXO1/PIK3R1/EP300/FGFR1/CREB5/AR/PLAT/PDGFC/CTNNB1/SOS2/SOS1/IGF1R/RB1/HSP90AB1/RAF1/SRD5A2/AKT3/MDM2/BRAF/GSK3B/CREBBP/PIK3CA/CREB1/SPINT1/NRAS/KLK3/PIK3CD/MAPK1/CHUK	6.20063625369731
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	25/1005	77/9376	3.02901079020482	GADD45G/TGFB2/SMAD3/GADD45A/PIK3R1/GADD45B/SHC2/PTPN11/SOS2/SOS1/RB1/RAF1/AKT3/MDM2/BRAF/POLK/HDAC2/PIK3CA/ABL1/NRAS/CBL/TGFB1/PIK3CD/MAPK1/CHUK	6.19429084791735
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	38/1005	150/9376	2.36343615257048	HGF/GADD45G/LEF1/WNT2/JUP/WNT5A/TGFB2/SMAD3/ABCB1/GADD45A/PIK3R1/AXIN2/GADD45B/WNT16/SHC2/CTNNB1/SOS2/FZD3/CTNNA1/SOS1/RB1/RAF1/FGF18/AKT3/APC/FGF7/FGF10/BRAF/POLK/GSK3B/FGF2/PIK3CA/GAB1/NRAS/CSNK1A1/TGFB1/PIK3CD/MAPK1	5.83248603985718
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	21/1005	59/9376	3.32061725271945	GADD45G/LEF1/GADD45A/PIK3R1/AXIN2/GADD45B/CTNNB1/SOS2/CTNNA1/SOS1/RAF1/AKT3/APC/BRAF/POLK/GSK3B/FOXO3/PIK3CA/NRAS/PIK3CD/MAPK1	6.19543026376418
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	25/1005	80/9376	2.91542288557214	HGF/STAT3/PIK3R1/IL6R/SHC2/PDGFC/SOS2/SOS1/IGF1R/RAF1/AKT3/NF1/PRKCB/BCL2L11/BRAF/GSK3B/FOXO3/FGF2/PIK3CA/GAB1/JAK2/NRAS/PIK3CD/MAPK1/VEGFA	5.9613086215836
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	51/1005	238/9376	1.99914712153518	HGF/NTF3/AFDN/INSR/MAPK10/ETS2/PIK3R1/FGFR1/SHC2/RASA3/PLD1/PTPN11/GNG12/PDGFC/SOS2/RGL1/PAK1/MRAS/RALGAPB/SOS1/IGF1R/RAF1/RALGAPA1/FGF18/RALBP1/AKT3/GNG4/BDNF/NF1/PRKCB/GNB5/FGF7/FGF10/STK4/FGF2/HTR7/PIK3CA/RASA1/ABL1/GAB1/NRAS/SHOC2/RRAS2/PAK2/PLA2G4C/PIK3CD/RAB5B/MAPK1/CHUK/TBK1/VEGFA	5.40968953376428
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	40/1005	169/9376	2.20813094291854	PRKAA2/RB1CC1/MAPK10/DEPTOR/PIK3R1/VMP1/SH3GLB1/VPS41/LAMP2/HIF1A/WDFY3/OPTN/TAX1BP1/MRAS/TANK/IGF1R/RAF1/CALCOCO2/MAP1LC3A/AKT3/EPG5/RRAGB/PPP2CA/CFLAR/PIK3CA/BIRC6/PPP2CB/TSC1/MAP1LC3B/NRAS/SUPT20H/ATG5/RRAS2/ULK2/PIK3CD/NBR1/MAPK1/TBK1/EIF2AK3/SQSTM1	5.49133939794562
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	69/1005	362/9376	1.7782468871114	LAMA3/HGF/HSP90AA1/LAMB1/PRKAA2/LAMC1/PPP2R3A/NTF3/LAMA4/SGK1/OSMR/INSR/FN1/PIK3R1/NR4A1/SGK3/COL6A1/MCL1/FGFR1/IL6R/CREB5/PKN2/YWHAZ/GNG12/TNC/PDGFC/SOS2/COL4A4/IFNAR1/LPAR2/ITGA5/SOS1/IGF1R/HSP90AB1/RAF1/PPP2R5B/FGF18/AKT3/GNG4/BDNF/MDM2/GNB5/PPP2R1B/FGF7/FGF10/ITGB8/BCL2L11/TNXB/IFNA13/GSK3B/FOXO3/FGF2/ATF2/PPP2CA/PIK3CA/PPP2CB/TSC1/CREB1/JAK2/NRAS/COL9A3/LAMA1/THBS1/PHLPP1/PIK3CD/MAPK1/CHUK/PHLPP2/VEGFA	5.23230315579775
Human Diseases	Cancer: specific types	hsa05218	Melanoma	23/1005	73/9376	2.93938526545355	HGF/GADD45G/MITF/GADD45A/PIK3R1/GADD45B/FGFR1/PDGFC/IGF1R/RB1/RAF1/FGF18/AKT3/MDM2/FGF7/FGF10/BRAF/POLK/FGF2/PIK3CA/NRAS/PIK3CD/MAPK1	5.76360234539271
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	44/1005	196/9376	2.09434460351305	ZFP36/FOS/LEF1/STAT3/LYN/MAPK10/PIK3R1/PPP3R1/ITPR2/JUN/EP300/HIF1A/GNG12/CTNNB1/IFNAR1/IL6ST/RB1/RAF1/MAP1LC3A/AKT3/GNG4/GNB5/IFNA13/GSK3B/FGF2/CREBBP/HLA-E/IRF9/PIK3CA/STAT2/MAP1LC3B/PPP3CB/CREB1/CASP3/JAK2/NRAS/C3/PIK3CD/MAPK1/CHUK/TBK1/IFNGR1/MAP2K4/VEGFA	5.36464259845494
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	34/1005	139/9376	2.28200007158452	FOS/HSP90AA1/PGR/HSPA1A/PIK3R1/GNAQ/GREB1/ITPR2/JUN/SHC2/CREB5/PLCB1/ESR1/GNAI1/SP1/NCOA1/HSPA1B/SOS2/EBAG9/SOS1/HSPA8/HSP90AB1/RAF1/AKT3/NCOA3/ADCY2/ATF2/NCOA2/PIK3CA/CREB1/NRAS/PIK3CD/MAPK1/ADCY6	5.27606303848085
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	31/1005	122/9376	2.37057336269472	FOS/JUNB/SOCS3/STAT3/MAPK10/PIK3R1/GNAQ/ITPR2/EP300/SHC2/CREB5/PLCB1/GNAI1/MRAP2/SOS2/SOS1/RAF1/AKT3/PRKCB/GSK3B/CREBBP/ADCY2/ATF2/PIK3CA/CREB1/JAK2/NRAS/PIK3CD/MAPK1/ADCY6/MAP2K4	5.27955663301652
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	44/1005	203/9376	2.02212582408156	LAMA3/HGF/LAMB1/LAMC1/LAMA4/FN1/MAPK10/PIK3R1/COL6A1/CAV2/JUN/SHC2/VCL/ACTG1/DOCK1/VAV3/TNC/PDGFC/CTNNB1/SOS2/COL4A4/PAK1/ITGA5/ARHGAP5/SOS1/IGF1R/RAF1/AKT3/PRKCB/ITGB8/FYN/BRAF/TNXB/GSK3B/PIK3CA/COL9A3/LAMA1/THBS1/PAK2/PIK3CD/MAPK1/ROCK1/MYLK/VEGFA	5.10125086265797
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	24/1005	83/9376	2.69764430857759	EP300/PCGF5/L3MBTL3/BMI1/AUTS2/PHC2/MBD5/RBBP4/ASXL3/AEBP2/PHC3/OGT/MGA/CREBBP/HDAC2/LCOR/CBX2/MTF2/FOXK2/UBE2D1/E2F6/ASXL1/USP7/JARID2	5.38254634058199
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	51/1005	250/9376	1.90318805970149	NEDD4L/RAB31/RAB11FIP1/HSPA1A/ACTR3B/PSD3/ZFYVE16/SMAD3/CAV2/SH3GLB1/IGF2R/PRKCI/PLD1/WASHC4/PDCD6IP/CXCR4/EPN2/HSPA1B/NEDD4/ARFGEF1/WASHC2C/EEA1/HSPA8/IGF1R/ARFGAP3/SMURF2/PARD6G/ACTR3/ACTR2/RAB11FIP4/ACAP2/MDM2/ARPC5/ZFYVE9/CYTH3/ITCH/SNX4/SPG21/HLA-E/ARF5/CBLB/KIF5B/VPS35/ARFGEF2/AGAP2/CBL/RAB5B/SMAP2/SPART/GRK3/WASHC2A	5.01519654612174
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	22/1005	73/9376	2.81158590608601	HGF/GADD45G/STAT3/GADD45A/PIK3R1/GADD45B/SOS2/SOS1/RB1/RAF1/AKT3/PRKCB/STK4/BRAF/POLK/FOXO3/FHIT/PIK3CA/KIF5B/NRAS/PIK3CD/MAPK1	5.38379916728709
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	36/1005	157/9376	2.13921475425421	GADD45G/TGFB2/HIPK2/HIPK3/SMAD3/GADD45A/FOXO1/PIK3R1/PPP3R1/ITPR2/GADD45B/ZFP36L2/ZFP36L1/MRAS/RB1/TRAF3IP2/RAF1/TRPM7/SIRT1/AKT3/RBBP4/MDM2/FOXO3/HLA-E/PPID/PIK3CA/TSC1/PPP3CB/NRAS/RRAS2/TGFB1/PIK3CD/MAPK1/RAD50/HUS1/SQSTM1	4.98762183815016
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	24/1005	86/9376	2.60354043734814	MAPK10/PIK3R1/JUN/SHC2/CAMK2D/SOS2/PAK1/SOS1/RAF1/NCK2/AKT3/PRKCB/BRAF/GSK3B/CBLB/PIK3CA/ABL1/GAB1/NRAS/CBL/PAK2/PIK3CD/MAPK1/MAP2K4	5.17608361052361
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	30/1005	122/9376	2.2941032542207	FOS/PPP2R3A/MAPK10/PIK3R1/PPP3R1/JUN/VAV3/PTPN11/SOS2/PAK1/SOS1/RAF1/NCK2/PPP2R5B/AKT3/PPP2R1B/FYN/MALT1/GSK3B/PPP2CA/CBLB/PIK3CA/PPP2CB/PPP3CB/NRAS/PAK2/PIK3CD/MAPK1/CHUK/DLG1	4.98498774716882
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	30/1005	122/9376	2.2941032542207	DIO2/FOXO1/PIK3R1/NOTCH2/EP300/HIF1A/PLCB1/ACTG1/ESR1/MED24/MED13/NCOA1/CTNNB1/TBC1D4/NCOR1/RAF1/AKT3/MDM2/PRKCB/ATP2A2/NCOA3/GSK3B/CREBBP/HDAC2/NCOA2/PIK3CA/MED13L/NRAS/PIK3CD/MAPK1	4.98498774716882
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	27/1005	105/9376	2.39897654584222	MITF/BNIP3L/MAPK10/JUN/HIF1A/HUWE1/SP1/OPTN/TAX1BP1/MRAS/CALCOCO2/SMURF2/MAP1LC3A/OPA1/FOXO3/MAP1LC3B/NRAS/RRAS2/TBC1D15/SIAH1/NBR1/RAB5B/CCZ1B/TBK1/USP15/EIF2AK3/SQSTM1	4.99484241077856
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	47/1005	232/9376	1.88999828443987	CXCL12/ACTR3B/IQGAP1/FN1/PIK3R1/FGFR1/VCL/ACTG1/MYH10/DOCK1/VAV3/CXCR4/GNG12/PDGFC/SOS2/PAK1/LPAR2/MRAS/ITGA5/NCKAP1/SOS1/RAF1/FGF18/ACTR3/AKT3/ACTR2/ARHGEF12/APC/FGF7/FGF10/ARPC5/ITGB8/PIKFYVE/BRAF/FGF2/PIK3CA/DIAPH2/NRAS/WASF1/RRAS2/PAK2/PIK3CD/MAPK1/ROCK1/MYLK/PIP4K2A/DIAPH3	4.75603510297512
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	22/1005	77/9376	2.66552949538024	GADD45G/STAT3/TGFB2/SMAD3/MAPK10/GADD45A/PIK3R1/GADD45B/PLD1/RB1/RAF1/RALBP1/AKT3/BRAF/POLK/PIK3CA/TGFB1/PIK3CD/MAPK1/CHUK/BRCA2/VEGFA	5.08463245241234
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	22/1005	78/9376	2.63135604031126	ACTR3B/FN1/PIK3R1/ARHGEF26/CAV2/SHC2/VCL/ACTG1/HCLS1/DOCK1/CTNNB1/ITGA5/CTNNA1/ACTR3/ACTR2/ARPC5/PIK3CA/GAB1/CBL/WASF1/PIK3CD/ARHGAP10	5.01281046107536
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	19/1005	62/9376	2.85899534585139	PRKAA2/HSPA1A/INSR/FOXO1/PIK3R1/HSPA1B/HSPA8/IGF1R/SIRT1/AKT3/FOXO3/ADCY2/HDAC2/PIK3CA/NRAS/ATG5/PIK3CD/ADCY6/PRKAG2	5.08845605894221
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	35/1005	158/9376	2.0666288809119	RPS6KA2/PRKAA2/WNT2/WNT5A/SGK1/INSR/DEPTOR/PIK3R1/CLIP1/PRR5L/WNT16/FNIP1/SLC3A2/SOS2/FZD3/SOS1/IGF1R/FNIP2/RAF1/AKT3/ATP6V1D/PRKCB/ATP6V1C1/BRAF/GSK3B/RRAGB/PIK3CA/TSC1/NRAS/ULK2/SLC38A9/CASTOR2/PIK3CD/MAPK1/CHUK	4.68493455514752
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	24/1005	93/9376	2.40757502808538	LEF1/IQGAP1/AFDN/INSR/SMAD3/NLK/EP300/FGFR1/VCL/ACTG1/CTNNB1/YES1/CTNNA1/FER/IGF1R/SMURF2/FYN/CREBBP/CTNND1/TJP1/WASF1/MAPK1/ROCK1/SSX2IP	4.72659999896768
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	26/1005	105/9376	2.31012556266288	MAPK10/PIK3R1/PPP3R1/ITPR2/JUN/CLEC4M/PTPN11/PAK1/MRAS/RAF1/AKT3/ARHGEF12/MDM2/IRF1/MALT1/IRF9/CBLB/PIK3CA/STAT2/BCL3/PPP3CB/NRAS/RRAS2/PIK3CD/MAPK1/CHUK	4.67761289013897
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	20/1005	71/9376	2.62798682643122	FOS/SOCS3/STAT3/MAPK10/PIK3R1/SHC2/ESR1/SOS2/SOS1/RAF1/AKT3/IRF1/GSK3B/FOXO3/PIK3CA/JAK2/NRAS/SOCS4/PIK3CD/MAPK1	4.77091709724448
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	35/1005	163/9376	2.00323535695754	FOS/STAT3/TGFB2/SMAD3/MAPK10/PIK3R1/JUN/EP300/CREB5/YWHAZ/SOS2/IFNAR1/DDX3X/SOS1/RB1/RAF1/AKT3/PRKCB/APAF1/BRAF/IFNA13/CREBBP/ATF2/PIK3CA/STAT2/CREB1/CASP3/JAK2/NRAS/TGFB1/PIK3CD/MAPK1/CHUK/TBK1/MAP2K4	4.47688660519354
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	27/1005	115/9376	2.19036988968202	FOS/GATA3/EGR1/JUND/SGK1/GNAQ/ITPR2/FGFR1/MEF2A/MEF2C/CREB5/PLCB1/PLD1/GNAI1/SP1/MMP14/MMP16/RAF1/PRKCB/BRAF/ADCY2/ATF2/AKAP13/CREB1/NR4A2/MAPK1/ADCY6	4.45022438464745
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	44/1005	227/9376	1.80833278541215	CXCL12/STAT3/PIK3R1/GNAQ/PPP3R1/ITPR2/IL6R/PTGER3/CREB5/PLCB1/GNAI1/CXCR4/SP1/GNG12/CTNNB1/SOS2/SOS1/RB1/RAF1/AKT3/GNG4/ARHGEF12/MDM2/PRKCB/GNB5/IFNA13/GSK3B/ADCY2/ATF2/HLA-E/PIK3CA/AKAP13/TSC1/PPP3CB/CREB1/CASP3/NRAS/PIK3CD/MAPK1/CHUK/ROCK1/TBK1/ADCY6/VEGFA	4.27165634833732
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	29/1005	130/9376	2.08116341370073	FOS/MAPK10/PIK3R1/JUN/SHC2/CREB5/PLCB1/GNAI1/COL3A1/GNG12/SOS2/COL4A4/SOS1/RAF1/AKT3/GNG4/GNB5/ADCY2/ATF2/PIK3CA/CREB1/NRAS/TGFB1/PIK3CD/MAPK1/ADCY6/RLN1/MAP2K4/VEGFA	4.30096660600871
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	24/1005	99/9376	2.2616613900196	FOS/MAPK10/PIK3R1/NOTCH2/JUN/SHC2/ESR1/SP1/SOS2/SOS1/IGF1R/RB1/NCOR1/RAF1/AKT3/MDM2/BRAF/NCOA3/ADCY2/PIK3CA/NRAS/PIK3CD/MAPK1/ADCY6	4.37256858143143
Human Diseases	Cancer: specific types	hsa05214	Glioma	20/1005	76/9376	2.45509295627127	GADD45G/GADD45A/PIK3R1/GADD45B/SHC2/CAMK2D/SOS2/SOS1/IGF1R/RB1/RAF1/AKT3/MDM2/PRKCB/BRAF/POLK/PIK3CA/NRAS/PIK3CD/MAPK1	4.41302165321145
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	33/1005	157/9376	1.96094685806636	CD24/SGK1/MEGF10/VPS41/CEBPB/CASP7/HIF1A/ADAM10/DOCK1/CAMK2D/PTPN11/ATP8A2/ANO6/DUSP8/DUSP16/ATP11B/ADAM17/SIRT1/PPARG/ATP2A2/DNMT3A/CREB1/CASP3/CD47/JAK2/ABCA1/THBS1/TGFB1/RAB5B/MAPK1/TMEM30A/GULP1/DUSP5	4.2071431367049
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	33/1005	157/9376	1.96094685806636	LEF1/WNT2/WNT5A/TGFB2/SMAD3/AXIN2/WNT16/ID2/PRKCI/ACTG1/LATS2/YWHAZ/DLG5/BMPR2/CTNNB1/FZD3/CTNNA1/TEAD1/TP53BP2/MOB1B/SMAD7/PARD6G/APC/PPP2R1B/GSK3B/CSNK1E/PPP2CA/YAP1/PPP2CB/LATS1/TGFB1/DLG1/PATJ	4.2071431367049
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	27/1005	119/9376	2.11674401103725	FOS/JUNB/SOCS3/MAPK10/PIK3R1/JUN/RHBDF2/CEBPB/CASP7/CREB5/MMP14/TNFAIP3/ADAM17/AKT3/IRF1/ITCH/ATF2/CFLAR/PIK3CA/BCL3/CREB1/CASP3/PIK3CD/MAPK1/CHUK/MAP2K4/LIF	4.2478774503835
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	24/1005	101/9376	2.2168760159598	STAT3/PIM1/EGR1/TGFB2/FN1/SMAD3/MAPK10/FOXO1/PIK3R1/JUN/PLCB1/COL3A1/COL4A4/AKT3/PRKCB/PIK3CA/AGT/CASP3/JAK2/NRAS/TGFB1/PIK3CD/MAPK1/VEGFA	4.26020067958334
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	46/1005	248/9376	1.73044455143637	TUBB2B/RHOB/FOS/HSP90AA1/LEF1/ACTR3B/MAPK10/SNX18/ARHGEF26/TUBA1A/DYNC1H1/JUN/AHNAK2/VPS41/CASP7/FYCO1/EXOC5/ACTG1/GCC2/PIK3C2A/TUBB2A/CTNNB1/ANXA2/PAK1/TUBB4A/NCKAP1/HSP90AB1/RAF1/ACTR3/AKT3/ACTR2/ARPC5/CYTH3/ABI1/PIK3CA/DYNLT3/KIF5B/MYO6/CASP3/PIK3CD/RAB5B/MAPK1/CHUK/DYNC1I2/KPNA4/MAP2K4	4.03929225422348
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	22/1005	90/9376	2.28050856826976	PRKAA2/RB1CC1/INSR/FOXO1/PIK3R1/CREB5/IGF1R/SIRT1/AKT3/PPARG/FOXO3/ADCY2/ATF2/PIK3CA/TSC1/CREB1/NRAS/ATG5/EHMT1/PIK3CD/ADCY6/PRKAG2	4.2293088581197
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	41/1005	216/9376	1.7708494564216	FOS/HSP90AA1/HSPA2/STAT3/HSPA1A/LYN/MAPK10/PIK3R1/PPP3R1/JUN/MIB1/CASP7/PLCB1/VAV3/CAMK2D/NFE2L2/HSPA1B/TANK/HSPA8/HSP90AB1/AKT3/PPARG/APAF1/ERO1A/IFNA13/GSK3B/CASP6/PIK3CA/PPP3CB/CASP3/JAK2/NRAS/ABCA1/HSPD1/PIK3CD/MAPK1/CHUK/TBK1/POU2F1/MAP2K4/EIF2AK3	3.9712635288752
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	41/1005	217/9376	1.76268885984822	RPS6KA2/FOS/HSP90AA1/PGR/STAT3/PIK3R1/GSTA1/NOTCH2/JUN/AHR/CREB5/AR/ESR1/GNAI1/CACNA1B/SOS2/EPHX1/BCL6/GSTA4/SOS1/RB1/HSP90AB1/RAF1/FGF18/AKT3/PRKCB/FGF7/FGF10/FGF2/ADCY2/ATF2/PIK3CA/KLF4/CREB1/JAK2/NRAS/PIK3CD/MAPK1/ADCY6/KPNA4/VEGFA	3.9385216622852
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	34/1005	170/9376	1.86587064676617	NEDD4L/PRKAA2/CGNL1/ACTR3B/AFDN/MAPK10/MPDZ/TUBA1A/JUN/PRKCI/ACTG1/HCLS1/MYH10/AMOTL2/NEDD4/RAB8B/PARD6G/ACTR3/ACTR2/PPP2R1B/ARPC5/PPP2CA/PPP2CB/TJP1/RAPGEF2/TJP2/WHAMM/ARHGEF2/ROCK1/DLG1/PATJ/JAM2/OCLN/PRKAG2	3.94749865515861
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	29/1005	137/9376	1.9748265969423	FOS/GADD45G/MAPK10/GADD45A/PIK3R1/TUBA1A/ITPR2/MCL1/JUN/GADD45B/PMAIP1/CASP7/ACTG1/RAF1/AKT3/BCL2L11/APAF1/CFLAR/CASP6/PIK3CA/CASP3/NRAS/PIK3CD/PARP2/MAPK1/CHUK/SPTAN1/EIF2AK3/CTSV	3.98249434692963
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	43/1005	233/9376	1.72172613328209	VIM/ANK2/SUN1/SDC2/FBN1/JUP/COL27A1/COL11A1/FMNL2/FN1/VCAN/COL5A2/COL6A1/SGCE/PKP2/VCL/SYNE2/ACTG1/MYH10/COL3A1/LBR/TMOD3/DMD/COL4A4/TPM4/ITGA5/FBN2/FHL3/TMOD2/TMOD1/DSG2/ITGB8/NEB/ANK3/DTNA/DIAPH2/SYNE1/COL9A3/LAMA1/THBS1/FMN2/DIAPH3/SPTAN1	3.86532512651761
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	23/1005	99/9376	2.16742549876878	FOS/MAPK10/PIK3R1/JUN/HIF1A/PLD1/DGKI/SP1/PDGFC/SOS2/SOS1/RAF1/DGKE/AKT3/PRKCB/PIK3CA/TSC1/NRAS/WASF1/PLA2G4C/PIK3CD/MAPK1/GPCPD1	4.04597310931343
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	38/1005	201/9376	1.76375832281379	DDX5/GADD45G/MITF/PROM1/JUP/JMJD1C/RUNX1T1/WT1/HPGD/GADD45A/FOXO1/GADD45B/WNT16/ID2/KMT2A/AFF1/HOXA10/CEBPB/MEF2C/BMI1/PLAT/SP1/KLF3/CCNT2/BMP2K/BCL6/IGF1R/NCOR1/HOXA11/MDM2/PPARG/POLK/LMO2/HDAC2/SPINT1/LDB1/KDM6A/MLLT3	3.79254677853448
NA	NA	hsa04518	Integrin signaling	31/1005	154/9376	1.87798668992699	LAMA3/HGF/LAMB1/LAMC1/FBN1/LAMA4/FN1/PIK3R1/COL6A1/VCL/ACTG1/TNC/PDGFC/CTNNB1/COL4A4/ITGA5/IGF1R/NCK2/AKT3/FERMT2/ITGB8/TNXB/GSK3B/PIK3CA/COL9A3/LAMA1/THBS1/C3/TGFB1/PIK3CD/VEGFA	3.80641145573741
Organismal Systems	Nervous system	hsa04730	Long-term depression	16/1005	60/9376	2.48782752902156	LYN/GNAQ/ITPR2/GRID2/PLCB1/GNAI1/IGF1R/RAF1/PRKCB/PPP2R1B/BRAF/PPP2CA/PPP2CB/NRAS/PLA2G4C/MAPK1	4.00583884377897
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	29/1005	142/9376	1.90529044916264	FOS/JUNB/MITF/SOCS3/FOSB/JUND/TGFB2/MAPK10/FOSL2/PIK3R1/PPP3R1/ITPR2/JUN/IFNAR1/AKT3/PPARG/FYN/ATP2A2/IRF9/PIK3CA/STAT2/PPP3CB/CREB1/TGFB1/PIK3CD/MAPK1/CHUK/IFNGR1/SQSTM1	3.76631962983086
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	29/1005	142/9376	1.90529044916264	FOS/HSP90AA1/PRKAA2/SDC2/DUSP1/MAPK10/PIK3R1/GSTA1/CAV2/JUN/MEF2A/MEF2C/ACTG1/KLF2/PLAT/NFE2L2/BMPR2/CTNNB1/GSTA4/HSP90AB1/AKT3/PIK3CA/ACVR2A/PIK3CD/CHUK/ARHGEF2/MAP2K4/SQSTM1/VEGFA	3.76631962983086
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	23/1005	103/9376	2.08325363473893	FOS/TGFB2/GNA14/MAPK10/PIK3R1/GNAQ/GNAL/JUN/PLCB1/GNAI1/AKT3/PPP2R1B/PPP2CA/CFLAR/PIK3CA/PPP2CB/C3/TGFB1/PIK3CD/MAPK1/CHUK/IFNGR1/MAP2K4	3.83017516098164
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	30/1005	149/9376	1.87839326855655	INSR/PIK3R1/SHC2/PLCB1/PLD1/AGPAT4/DGKI/PTPN11/PDGFC/SOS2/LPAR2/MRAS/GRM8/SOS1/RAF1/DGKE/AKT3/CYTH3/FYN/ADCY2/PIK3CA/AGT/TSC1/GAB1/NRAS/RRAS2/PLA2G4C/PIK3CD/MAPK1/ADCY6	3.74482796237068
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	25/1005	116/9376	2.01063647280837	SLC38A2/GNAQ/PPP3R1/ITPR2/GRIN3A/HOMER2/GRIK2/PLCB1/PLD1/GNAI1/GNG12/GRM8/GNG4/PRKCB/GNB5/LZTS3/GLUL/ADCY2/PPP3CB/SLC1A2/HOMER1/PLA2G4C/MAPK1/GRK3/ADCY6	3.79488366491009
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	39/1005	212/9376	1.71624894395945	HGF/AFDN/INSR/PIK3R1/GNAQ/DOCK4/FGFR1/SIPA1L1/PRKCI/PLCB1/ACTG1/VAV3/EVL/GNAI1/PDGFC/CTNNB1/LPAR2/MRAS/IGF1R/RAF1/FGF18/PARD6G/AKT3/PRKCB/FGF7/FGF10/BRAF/FGF2/ADCY2/PIK3CA/CTNND1/MAGI3/RAPGEF2/NRAS/THBS1/PIK3CD/MAPK1/ADCY6/VEGFA	3.65484853016885
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	34/1005	178/9376	1.78201129185533	WIF1/LEF1/WNT2/WNT5A/SMAD3/MAPK10/DKK2/AXIN2/PPP3R1/NLK/JUN/EP300/WNT16/GPC4/TLE3/PLCB1/CAMK2D/TBL1XR1/CTNNB1/FZD3/SFRP1/SIRT1/ROR1/APC/PRKCB/GSK3B/CSNK1E/CREBBP/CELSR2/PPP3CB/CSNK1A1/SIAH1/RSPO3/BAMBI	3.64969288370489
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	28/1005	140/9376	1.86587064676617	PRKAA2/EGR1/SMAD3/GNAQ/ITPR2/MEF2A/MEF2C/PLCB1/KLF2/GNAI1/PLAT/GNG12/MRAS/RAF1/MAP1LC3A/AKT3/GNG4/GNB5/ADCY2/MAP1LC3B/NRAS/HDAC5/RRAS2/MAPK1/MYLK/ADCY6/PDE3B/PRKAG2	3.5764739904648
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	25/1005	120/9376	1.94361525704809	RPS6KA2/NTF3/KIDINS220/MAPK10/PIK3R1/JUN/SHC2/CAMK2D/PTPN11/SOS2/SOS1/FRS2/RAF1/AKT3/BDNF/BRAF/GSK3B/FOXO3/SORT1/PIK3CA/ABL1/GAB1/NRAS/PIK3CD/MAPK1	3.60457364006286
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	30/1005	155/9376	1.80568127106403	LEF1/WNT2/PDE8B/WNT5A/NR4A1/GNAQ/AXIN2/ITPR2/WNT16/KMT2A/AHR/CREB5/PLCB1/GNAI1/CAMK2D/SP1/CTNNB1/FZD3/RB1/KCNA4/APC/BRAF/GSK3B/ADCY2/ATF2/AGT/CREB1/MAPK1/RASD1/ADCY6	3.50445190651021
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	28/1005	142/9376	1.83959077850186	NEDD4L/SOCS3/KLHL9/TRIP12/CUL4B/UBE3A/UBR5/HUWE1/UBE2H/NEDD4/UBE2B/SMURF2/MDM2/ITCH/CDC16/CUL3/HERC1/CBLB/MID1/BIRC6/CBL/CUL2/UBE2D1/CUL5/SIAH1/HERC4/RHOBTB1/PIAS2	3.4929864034481
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	23/1005	109/9376	1.96857912273495	FOS/HSP90AA1/STAT3/GATA3/HLA-DQA2/SMAD3/MAPK10/PPP3R1/JUN/RORA/IL6R/HLA-DQB1/AHR/HIF1A/HLA-DQA1/IL6ST/HSP90AB1/PPP3CB/JAK2/TGFB1/MAPK1/CHUK/IFNGR1	3.52418557617206
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	36/1005	200/9376	1.67928358208955	TUBB2B/FOS/ACTR3B/MAPK10/TUBA1A/JUN/CASP7/ACTG1/HCLS1/TUBB2A/MYH10/PTPN11/PAK1/LPAR2/TUBB4A/NCKAP1/MYO1E/NCK2/ACTR3/ACTR2/ARHGEF12/ARPC5/CYTH3/FYN/ABI1/MYO6/ABL1/CASP3/TJP1/WASF1/PAK2/MAPK1/CHUK/ARHGEF2/ROCK1/OCLN	3.36449131494617
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	35/1005	193/9376	1.69185162271544	CXCL12/STAT3/LYN/PIK3R1/GNAQ/SHC2/PLCB1/VAV3/GNAI1/CXCR4/GNG12/SOS2/PAK1/SOS1/RAF1/AKT3/GNG4/PRKCB/GNB5/BRAF/GSK3B/FOXO3/ADCY2/CCR6/PIK3CA/STAT2/JAK2/NRAS/CCL28/PIK3CD/MAPK1/CHUK/ROCK1/GRK3/ADCY6	3.3649554930824
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	11/1005	37/9376	2.77359150194971	GADD45G/LEF1/GADD45A/GADD45B/CTNNB1/TPR/PPARG/BRAF/POLK/NRAS/MAPK1	3.7452798294738
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	20/1005	91/9376	2.05040730413865	FOS/IFITM1/LYN/PIK3R1/PPP3R1/JUN/VAV3/SOS2/SOS1/RAF1/AKT3/PRKCB/MALT1/GSK3B/PIK3CA/PPP3CB/NRAS/PIK3CD/MAPK1/CHUK	3.48873091131567
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	25/1005	125/9376	1.86587064676617	PPP2R3A/MAPK10/PIK3R1/GNAQ/PLCB1/PLD1/CERS6/GNAI1/S1PR3/ABCC1/RAF1/PPP2R5B/SGPP1/AKT3/PRKCB/PPP2R1B/FYN/PPP2CA/PIK3CA/PPP2CB/NRAS/PIK3CD/MAPK1/ROCK1/CERS2	3.37670935746556
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	26/1005	133/9376	1.82378333894438	SLC18A2/FOS/PPP2R3A/MAPK10/GNAQ/GNAL/ITPR2/CREB5/PLCB1/GNAI1/CACNA1B/CAMK2D/GNG12/PPP2R5B/AKT3/GNG4/PRKCB/GNB5/PPP2R1B/GSK3B/ATF2/PPP2CA/PPP2CB/KIF5B/PPP3CB/CREB1	3.31521994214867
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	31/1005	168/9376	1.72148779909974	SOCS3/STAT3/PIM1/OSMR/PIK3R1/MCL1/EP300/IL6R/IL13RA1/PTPN11/SOS2/IFNAR1/SOS1/IL6ST/RAF1/AKT3/LIFR/IFNA13/CREBBP/IRF9/PIK3CA/STAT2/LEPR/JAK2/SOCS4/PIK3CD/IL31RA/CLCF1/IFNGR1/PIAS2/LIF	3.2694972387174
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	20/1005	93/9376	2.00631252340448	EGR1/MAPK10/GNAQ/ITPR2/JUN/MAP3K4/PLCB1/PLD1/CAMK2D/MMP14/SOS2/SOS1/RAF1/PRKCB/ADCY2/NRAS/PLA2G4C/MAPK1/ADCY6/MAP2K4	3.3791710403918
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	20/1005	93/9376	2.00631252340448	LAMA3/LAMB1/GADD45G/LAMC1/LAMA4/FN1/GADD45A/PIK3R1/GADD45B/COL4A4/RB1/AKT3/APAF1/POLK/FHIT/PIK3CA/CASP3/LAMA1/PIK3CD/CHUK	3.3791710403918
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	16/1005	68/9376	2.19514193737196	LEF1/STAT3/PIM1/JUP/RUNX1T1/PIK3R1/SOS2/SOS1/RAF1/AKT3/BRAF/PIK3CA/NRAS/PIK3CD/MAPK1/CHUK	3.42709192089159
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	21/1005	101/9376	1.93976651396483	LEF1/MITF/WNT2/WNT5A/GNAQ/EP300/WNT16/PLCB1/GNAI1/CAMK2D/CTNNB1/FZD3/RAF1/PRKCB/GSK3B/CREBBP/ADCY2/CREB1/NRAS/MAPK1/ADCY6	3.29005904375954
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	29/1005	156/9376	1.73430284475061	SOCS3/STAT3/PIK3R1/YWHAZ/CTNNB1/SOS2/IFNAR1/SOS1/RB1/RAF1/AKT3/PPP2R1B/APAF1/BRAF/IFNA13/GSK3B/PPP2CA/IRF9/CFLAR/PIK3CA/STAT2/PPP2CB/CASP3/NRAS/PIK3CD/MAPK1/CHUK/TBK1/OCLN	3.20443928584201
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	15/1005	63/9376	2.22127457948353	PRDM2/SETD7/KMT2A/PRDM6/SETD2/KMT5B/ALDH3A2/KMT2E/KMT5A/PHYKPL/SMYD3/KMT2C/ASH1L/TMLHE/EHMT1	3.36991377485117
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	23/1005	115/9376	1.86587064676617	FOS/PIK3R1/GNAQ/ITPR2/CREB5/PLCB1/GNAI1/CACNA1B/CAMK2D/GNG12/AKT3/GNG4/PRKCB/GNB5/FYN/ADCY2/PIK3CA/CREB1/JAK2/NRAS/PIK3CD/MAPK1/ADCY6	3.23707672681352
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	10/1005	34/9376	2.74392742171495	PRKAA2/BHLHE40/RORA/CRY1/NR1D2/FBXL3/CSNK1E/NPAS2/CREB1/PRKAG2	3.52961983876398
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	24/1005	122/9376	1.83528260337656	PRKAA2/PPP2R3A/INSR/FOXO1/PIK3R1/CREB5/IGF1R/SIRT1/PPP2R5B/AKT3/TBC1D1/PPARG/PPP2R1B/SCD5/FOXO3/PPP2CA/PIK3CA/PPP2CB/TSC1/LEPR/CREB1/PFKFB4/PIK3CD/PRKAG2	3.21757443208261
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	9/1005	29/9376	2.89531652084406	DCHS2/LATS2/PAK1/TEAD1/FAT4/MOB1B/CSNK1E/YAP1/LATS1	3.5418048143753
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	42/1005	253/9376	1.54874638664386	CD44/ACTR3B/MAPK10/FOXO1/FNBP1L/PIK3R1/ITPR2/JUN/VCL/PLCB1/ACTG1/HCLS1/DOCK1/ITGA5/CALCOCO2/MAP1LC3A/ACTR3/AKT3/ACTR2/MDM2/ARPC5/CYTH3/MALT1/GSK3B/RRAGB/FOXO3/HK1/TIFA/PPID/PIK3CA/MAP1LC3B/ATG5/WASF1/UBE2D1/C3/PIK3CD/MAPK1/CHUK/ARHGEF2/ROCK1/TBK1/SQSTM1	3.06579488152518
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	29/1005	158/9376	1.71234964418414	GADD45G/ATRX/TGFB2/SMAD3/GADD45A/GADD45B/EP300/NIPBL/STAG2/YWHAZ/PDS5A/RB1/PPP2R5B/PDS5B/RAD21/PRKDC/MDM2/PPP2R1B/CDC16/SMC1A/SMC3/GSK3B/CREBBP/HDAC2/PPP2CA/PPP2CB/ABL1/CDC14B/TGFB1	3.12884033341771
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	21/1005	103/9376	1.90210114476163	LAMA3/LAMB1/LAMC1/LAMA4/TGFB2/GNA14/FN1/PIK3R1/GNAQ/GNAL/VCL/PLCB1/COL3A1/COL4A4/PRKCB/PIK3CA/CASP3/LAMA1/TGFB1/PIK3CD/RAB5B	3.189655023121
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	26/1005	138/9376	1.75770423246088	PRKAA2/SOCS3/INSR/MAPK10/FOXO1/PIK3R1/SHC2/PRKCI/SOS2/RHOQ/SOS1/RAF1/AKT3/BRAF/GSK3B/HK1/CBLB/PIK3CA/TSC1/NRAS/SOCS4/CBL/PIK3CD/MAPK1/PDE3B/PRKAG2	3.10692146498119
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	26/1005	138/9376	1.75770423246088	RPS6KA2/FOS/ACTR3B/FN1/MAPK10/PIK3R1/GNAQ/JUN/PKN2/ACTG1/DOCK1/VAV3/ITGA5/ACTR3/AKT3/ACTR2/ARHGEF12/ARPC5/GSK3B/PIK3CA/PIK3CD/MAPK1/CHUK/ROCK1/TBK1/MAP2K4	3.10692146498119
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	32/1005	181/9376	1.64938841703087	PLA2R1/TGFB2/HLA-DQA2/MAPK10/PPP3R1/CEBPG/EP300/HLA-DQB1/LAMP2/CEBPB/CAMK2D/CLEC4M/HLA-DQA1/EEA1/NFYB/RAF1/AKT3/ARHGEF12/APAF1/IFNA13/MALT1/CREBBP/PPP3CB/CREB1/CASP3/JAK2/C3/TGFB1/HSPD1/RAB5B/MAPK1/IFNGR1	3.05666579233769
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	22/1005	112/9376	1.83255152807392	LAMA3/LAMB1/LAMC1/STAT3/HSPA1A/LAMA4/TGFB2/HLA-DQA2/MAPK10/HLA-DQB1/GNAI1/HSPA1B/HLA-DQA1/HSPA8/AKT3/CASP3/JAK2/LAMA1/TGFB1/MAPK1/CHUK/IFNGR1	3.0711487971159
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	35/1005	205/9376	1.592816405776	VIM/CD44/GADD45G/STAT3/HLA-DQA2/LYN/MAPK10/GADD45A/PIK3R1/JUN/GADD45B/HLA-DQB1/NEDD4/IFNAR1/TNFAIP3/HLA-DQA1/RB1/AKT3/ENTPD1/MDM2/BCL2L11/APAF1/IFNA13/POLK/HDAC2/HLA-E/IRF9/PIK3CA/STAT2/CASP3/PIK3CD/CHUK/USP7/TBK1/MAP2K4	2.97350584037188
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	14/1005	62/9376	2.10662814957471	HEY2/DTX4/NOTCH2/EP300/MAML3/TLE3/ATXN1/ADAM17/SPEN/MAML1/ITCH/CREBBP/HDAC2/NUMB	3.02907090395136
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	21/1005	109/9376	1.79739832945365	RPS6KA2/PRKAA2/SLC27A6/SOCS3/STAT3/INSR/MAPK10/FOXO1/PIK3R1/CREB5/PTPN11/TBC1D4/AKT3/PRKCB/OGT/GSK3B/PIK3CA/AGT/CREB1/PIK3CD/PRKAG2	2.90134241505147
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	15/1005	69/9376	2.0281202682241	LYN/MAPK10/PIK3R1/VAV3/SOS2/SOS1/RAF1/AKT3/FYN/PIK3CA/NRAS/PLA2G4C/PIK3CD/MAPK1/MAP2K4	2.96991217944628
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	18/1005	89/9376	1.88683548549388	TUBB2B/GNAQ/TUBA1A/ITPR2/PLCB1/TUBB2A/GNAI1/PDGFC/SOS2/TUBB4A/SOS1/RAF1/PRKCB/ADCY2/TJP1/NRAS/MAPK1/ADCY6	2.91259661970654
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	19/1005	98/9376	1.80875215757945	MARCKS/ACTR3B/LYN/PIK3R1/PLD1/DOCK1/VAV3/PAK1/RAF1/ACTR3/AKT3/ACTR2/PRKCB/ARPC5/PIK3CA/WASF1/PLA2G4C/PIK3CD/MAPK1	2.78856841610831
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	20/1005	107/9376	1.74380434277212	PRKAA2/FOXO1/GNAQ/PPP3R1/ITPR2/EP300/CREB5/PLCB1/CAMK2D/PPP4R3A/SIRT1/AKT3/CREBBP/ADCY2/ATF2/PPP3CB/CREB1/PPP4R3B/PDE3B/PRKAG2	2.68110705579634
Human Diseases	Infectious disease: viral	hsa05162	Measles	24/1005	136/9376	1.64635645302897	FOS/STAT3/HSPA1A/MAPK10/PIK3R1/JUN/CLEC4M/HSPA1B/IFNAR1/TNFAIP3/HSPA8/CD46/AKT3/APAF1/IFNA13/GSK3B/IRF9/CBLB/PIK3CA/STAT2/CASP3/PIK3CD/CHUK/TBK1	2.63078620395972
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	13/1005	60/9376	2.02135986733002	PIK3R1/PPP3R1/SHC2/RAF1/AKT3/PRKCB/PIK3CA/PPP3CB/NRAS/PLA2G4C/PIK3CD/MAPK1/VEGFA	2.74991754771344
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	14/1005	67/9376	1.9494170936363	RPS6KA2/GNAQ/PPP3R1/ITPR2/EP300/PLCB1/CAMK2D/RAF1/PRKCB/BRAF/CREBBP/PPP3CB/NRAS/MAPK1	2.70223385627888
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	10/1005	42/9376	2.22127457948353	SLC40A1/SLC3A2/SLC7A11/FTL/SAT2/MAP1LC3A/GCLC/MAP1LC3B/GCLM/ATG5	2.74842608990572
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	20/1005	110/9376	1.6962460425147	STAT3/INSR/PIK3R1/EP300/IL6R/HIF1A/CAMK2D/IGF1R/AKT3/PRKCB/CREBBP/HK1/PIK3CA/CUL2/PIK3CD/MAPK1/IFNGR1/EPAS1/EGLN3/VEGFA	2.54503015457058
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	20/1005	110/9376	1.6962460425147	RPS6KA2/HSP90AA1/PGR/MAPK10/PIK3R1/GNAI1/CPEB2/IGF1R/HSP90AB1/RAF1/AKT3/CDC16/BRAF/ADCY2/CPEB4/PIK3CA/PIK3CD/MAPK1/ADCY6/PDE3B	2.54503015457058
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	26/1005	154/9376	1.57508561090651	FOS/PRKAA2/CD38/GNAQ/PPP3R1/NPR2/ITPR2/JUN/MEF2C/PLCB1/ACTG1/GNAI1/CAMK2D/CACNB4/RAF1/RGS2/PRKCB/ADCY2/PPP3CB/NRAS/PLA2G4C/MAPK1/ROCK1/MYLK/ADCY6/PRKAG2	2.49321827141401
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	17/1005	89/9376	1.78201129185533	LAMA3/CD44/LAMB1/LAMC1/LAMA4/FN1/COL6A1/TNC/COL4A4/ITGA5/SV2C/ITGB8/TNXB/CD47/COL9A3/LAMA1/THBS1	2.56832691348806
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	11/1005	49/9376	2.09434460351305	ST6GAL2/GALNT3/ST6GAL1/C1GALT1/C1GALT1C1/GALNT1/GXYLT1/OGT/GALNTL6/GALNT7/B3GLCT	2.66109972684104
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	14/1005	69/9376	1.89291225034249	SLC18A2/FOS/FOSB/PPP3R1/GRIN3A/JUN/CREB5/CAMK2D/SIRT1/PRKCB/HDAC2/ATF2/PPP3CB/CREB1	2.57933925575614
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	12/1005	56/9376	1.99914712153518	BOC/LRP2/CSNK1G3/SMURF2/CUL3/EFCAB7/GSK3B/CSNK1E/SPOP/CSNK1A1/GAS1/GRK3	2.59833711559846
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	17/1005	90/9376	1.76221116639027	FOS/STAT3/PIK3R1/PPP3R1/JUN/HIF1A/PTPN11/RAF1/AKT3/PIK3CA/PPP3CB/JAK2/NRAS/PIK3CD/MAPK1/CHUK/IFNGR1	2.51745792074466
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	35/1005	224/9376	1.45771144278607	ZFP36/FOS/EGR1/TGFB2/HLA-DQA2/SMAD3/MAPK10/ETS2/PIK3R1/PPP3R1/JUN/EP300/HLA-DQB1/CREB5/HLA-DQA1/RB1/NFYB/AKT3/CDC16/CREBBP/ADCY2/ATF2/CANX/HLA-E/PIK3CA/PPP3CB/CREB1/NRAS/TGFB1/PIK3CD/MAPK1/CHUK/DLG1/ADCY6/MAP2K4	2.40235824846841
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	13/1005	63/9376	1.9251046355524	GADD45G/LEF1/WNT2/WNT5A/GADD45A/AXIN2/GADD45B/WNT16/CTNNB1/FZD3/APC/POLK/GSK3B	2.55267972239712
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	9/1005	38/9376	2.20958366064415	NT5E/CD38/NNT/SIRT1/NMNAT2/NADK/SIRT2/NAMPT/NMRK1	2.58869433468783
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	14/1005	71/9376	1.83959077850186	LYN/MAPK10/JUN/ADAM10/PTPN11/PAK1/ADAM17/ATP6V1D/ATP6V1C1/CASP3/TJP1/CHUK/MAP2K4/JAM2	2.46047322669324
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	13/1005	65/9376	1.86587064676617	PDE8B/NR4A1/GNAQ/ITPR2/CREB5/PLCB1/SP1/KCNA4/ADCY2/ATF2/AGT/CREB1/ADCY6	2.42712157241733
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	16/1005	86/9376	1.73569362489876	LEF1/JUP/SGCE/PKP2/ACTG1/CACNB4/CDH2/DMD/CTNNB1/ITGA5/CTNNA1/DSG2/ITGB8/ATP2A2/DTNA/LAMA1	2.37475253227956
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	20/1005	115/9376	1.62249621457928	SLC18A2/APP/DUSP1/GNAQ/ITPR2/PLCB1/GNAI1/CACNA1B/GNG12/KCND2/RAF1/GNG4/PRKCB/GNB5/BRAF/HTR7/CASP3/NRAS/PLA2G4C/MAPK1	2.32721598343808
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	6/1005	21/9376	2.66552949538024	CHST7/CHST11/CSGALNACT1/CSGALNACT2/DSEL/CHST15	2.6474031283434
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	17/1005	94/9376	1.68722345718217	IL17RB/FOS/HSP90AA1/FOSB/JUND/MAPK10/JUN/CEBPB/TNFAIP3/TRAF3IP2/HSP90AB1/GSK3B/MAPK6/CASP3/MAPK1/CHUK/TBK1	2.32017700286979
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	20/1005	117/9376	1.59476123655228	BAZ2B/BPTF/ACTG1/BCL7A/PBRM1/BAZ1A/CECR2/SMARCA1/DPF3/SMARCC2/RBBP4/ARID2/EPC1/SMARCC1/SMARCA5/GATAD2B/HDAC2/PHF6/INO80D/BRD8	2.24302204856312
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	25/1005	155/9376	1.50473439255336	TUBB2B/PLA2R1/HLA-DQA2/TUBA1A/DYNC1H1/HLA-DQB1/LAMP2/ACTG1/TUBB2A/CLEC4M/HLA-DQA1/TUBB4A/ITGA5/EEA1/ATP6V1D/PIKFYVE/ATP6V1C1/CANX/HLA-E/THBS1/C3/RAB5B/C1R/DYNC1I2/STX12	2.19543070913004
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	10/1005	47/9376	1.9849687731555	SOCS3/INSR/MAPK10/PIK3R1/CACNA1B/HK1/PIK3CA/SOCS4/PIK3CD/MAPK1	2.34549138788222
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	22/1005	133/9376	1.54320128679909	PIK3R1/PPP3R1/SHC2/VAV3/PTPN11/SOS2/IFNAR1/PAK1/SOS1/RAF1/PRKCB/FYN/BRAF/IFNA13/HLA-E/PIK3CA/PPP3CB/CASP3/NRAS/PIK3CD/MAPK1/IFNGR1	2.18605020696923
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	5/1005	17/9376	2.74392742171495	LAMP2/PCDH9/MYH10/CLEC4M/PCDH7	2.49355034904337
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	17/1005	98/9376	1.61835719362372	PIK3R1/ITPR2/INPP4B/PLCB1/PIK3C2A/PPIP5K2/DGKI/DGKE/INPP4A/PRKCB/PIKFYVE/CDS1/PIK3CA/PIK3CD/SACM1L/PIP4K2A/IMPA1	2.13208870462034
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	27/1005	174/9376	1.44765826042203	HSP90AA1/PPP1R15A/HSPA1A/HSPH1/MAPK10/DNAJB1/DNAJA1/DERL3/SEC63/MAN1C1/NFE2L2/HSPA1B/ATXN3/HSPA8/HSP90AB1/DNAJC1/RAD23B/ERO1A/CANX/DNAJA2/UGGT1/UBE2D1/UBQLN1/OS9/BAG2/LMAN1/EIF2AK3	2.06519046158226
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	4/1005	12/9376	3.10978441127695	CLEC4M/NCAM1/NCAM2/CD46	2.53383305681951
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	13/1005	70/9376	1.73259417199716	HLA-DQA2/EIF4G2/SGCE/HLA-DQB1/ACTG1/DMD/HLA-DQA1/FYN/DTNA/HLA-E/ABL1/CASP3/LAMA1	2.13162572817688
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	25/1005	160/9376	1.45771144278607	NLGN1/PTPRD/NRXN1/CDH4/SDC2/LRRC4C/NRCAM/ALCAM/HLA-DQA2/CADM1/VCAN/SLITRK6/HLA-DQB1/NTNG1/NCAM1/CDH2/HLA-DQA1/NCAM2/ITGB8/LRRC4/HLA-E/NRXN3/LRRC4B/JAM2/OCLN	2.02330114047767
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	14/1005	78/9376	1.6744992983799	FOS/MAPK10/SERPING1/JUN/CASP7/GNAI1/ITGA5/C1S/IRF1/C2/CASP3/C3/MAPK1/C1R	2.0725930179298
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	22/1005	138/9376	1.48728819669767	RPS6KA2/PGR/PPP3R1/ITPR2/AR/YWHAZ/CAMK2D/CPEB2/IGF1R/PPP2R5B/SLK/PPP2R1B/CDC16/SMC1A/SMC3/ADCY2/CPEB4/PPP2CA/PPP2CB/PPP3CB/MAPK1/ADCY6	1.99809647761223
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	16/1005	93/9376	1.60505001872359	FOS/GATA3/HLA-DQA2/MAPK10/PPP3R1/NOTCH2/JUN/HLA-DQB1/MAML3/HLA-DQA1/MAML1/PPP3CB/JAK2/MAPK1/CHUK/IFNGR1	2.03174208181593
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	19/1005	116/9376	1.52808371933436	CXCL12/AFDN/PIK3R1/VCL/ACTG1/VAV3/GNAI1/CXCR4/PTPN11/CTNNB1/CTNNA1/ARHGAP5/PRKCB/PIK3CA/CTNND1/PIK3CD/ROCK1/JAM2/OCLN	1.98292495286475
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	12/1005	65/9376	1.72234213547646	PIK3R1/GNAQ/ITPR2/PLCB1/RAF1/KCNN1/AKT3/PRKCB/PIK3CA/NRAS/PIK3CD/MAPK1	2.02479687494752
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	8/1005	38/9376	1.96407436501702	NEDD4L/SGK1/INSR/PIK3R1/PRKCB/PIK3CA/PIK3CD/MAPK1	2.06326683150488
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	17/1005	103/9376	1.53979616480703	PPP2R3A/PABPC4L/SMG1/DDX39B/PPP2R5B/MSI2/PPP2R1B/PPP2CA/SMG7/PPP2CB/HBS1L/ACIN1/PAPOLA/PABPC5/PAPOLG/NUDT21/PCF11	1.90861474739971
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	17/1005	103/9376	1.53979616480703	COL14A1/COL7A1/COL21A1/COL27A1/COL11A1/SLC38A2/COL5A2/COL6A1/COL23A1/COL28A1/SLC3A2/COL3A1/COL16A1/PRCP/COL4A4/COL25A1/COL9A3	1.90861474739971
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	11/1005	59/9376	1.73937094190067	INSR/PIK3R1/PTGER3/GNAI1/AKT3/ADCY2/PIK3CA/NPY/PIK3CD/ADCY6/PDE3B	1.97392357754439
Organismal Systems	Immune system	hsa04611	Platelet activation	20/1005	126/9376	1.48084971965569	LYN/PIK3R1/GNAQ/ITPR2/PRKCI/PLCB1/ACTG1/GNAI1/COL3A1/AKT3/ARHGEF12/FYN/ADCY2/PIK3CA/PLA2G4C/PIK3CD/MAPK1/ROCK1/MYLK/ADCY6	1.88279818718734
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	26/1005	173/9376	1.4020993299399	SOCS3/HLA-DQA2/DNAJB1/PIK3R1/EP300/HLA-DQB1/ACTG1/IFNAR1/HLA-DQA1/RAF1/CALCOCO2/AKT3/PRKCB/APAF1/IFNA13/CREBBP/IRF9/PIK3CA/STAT2/CASP3/JAK2/PIK3CD/MAPK1/CHUK/TBK1/IFNGR1	1.84957389897569
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	7/1005	32/9376	2.0407960199005	MAPK10/PMAIP1/CASP7/BCL2L11/APAF1/BIRC6/CASP3	2.04340379287725
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	25/1005	166/9376	1.40502307738416	INSR/GNAQ/GTF2I/PPP3R1/NPR2/ITPR2/MEF2A/MEF2C/CREB5/PLCB1/GNAI1/RAF1/RGS2/AKT3/ATP2A2/ADCY2/ATF2/PPP3CB/ATP2B2/CREB1/MAPK1/ROCK1/MYLK/ADCY6/PDE3B	1.82424849302851
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	13/1005	75/9376	1.61708789386401	REV3L/PIK3R1/GSTA1/TOP2B/PMAIP1/GSTA4/AKT3/MDM2/APAF1/PIK3CA/CASP3/PIK3CD/MAPK1	1.85905754922789
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	22/1005	144/9376	1.4253178551686	PRKAA2/LEF1/MAPK10/FOXO1/ALDH3A2/TRA2A/CTNNB1/SIRT1/AKT3/SCD5/C2/IFNA13/GSK3B/FOXO3/CASP3/ACADM/C3/CHUK/TBK1/ADH5/MAP2K4/PRKAG2	1.78207903634702
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	44/1005	323/9376	1.27087164795219	VIM/CD44/MARCKS/STAT3/PIM1/STMN1/SOX4/TGFB2/ABCB1/PIK3R1/NOTCH2/MCL1/EP300/BMI1/TNC/BMPR2/SOS2/FZD3/ITGA5/ABCC1/SOS1/MMP16/RAF1/ZEB2/SIRT1/APC/MDM2/PRKCB/BCL2L11/TNXB/CREBBP/HDAC2/DNMT3A/PIK3CA/ABL1/CASP3/NRAS/HDAC5/THBS1/ZFPM2/PIK3CD/MAPK1/ROCK1/VEGFA	1.71651873948226
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	35/1005	250/9376	1.30610945273632	LAMP5/LAPTM4A/MITF/VPS13C/DEPTOR/MCOLN3/TPP1/VPS41/LAMP2/VPS13A/IGF2R/GALC/DMXL1/SCARB2/GNPTAB/AP5M1/ATP6V1D/BLOC1S6/PIKFYVE/NCOA7/ATP6V1C1/NPC2/RRAGB/SORT1/VPS35/OSBP/SLC38A9/HEXB/CLN3/GPR155/VAMP7/AP1S2/NEU1/CTSV/SPG11	1.69975571931918
Human Diseases	Substance dependence	hsa05032	Morphine addiction	15/1005	91/9376	1.53780547810399	PDE8B/GABRE/GNAI1/CACNA1B/GNG12/PDE7A/GNG4/PRKCB/GNB5/ADCY2/GABRQ/GRK3/ADCY6/GABRA5/PDE3B	1.78622005801344
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	32/1005	226/9376	1.32097036939198	FOS/AFDN/MAPK10/PIK3R1/GRIN3A/JUN/EP300/PTGER3/CREB5/PLD1/VAV3/GNAI1/CAMK2D/PAK1/RAF1/AKT3/BDNF/VIPR2/ATP2A2/BRAF/CREBBP/ADCY2/PIK3CA/NPY/ATP2B2/CREB1/RRAS2/PIK3CD/MAPK1/ROCK1/ADCY6/PDE3B	1.69234387023504
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	27/1005	187/9376	1.34701891611461	HSP90AA1/MAPK10/ITPR2/JUN/IFI16/PKN2/PLCB1/IFNAR1/NLRP1/TNFAIP3/TANK/NEK7/HSP90AB1/TRPM7/ERBIN/MAP1LC3A/IFNA13/IRF9/STAT2/NAMPT/MAP1LC3B/GBP3/ATG5/ANTXR2/MAPK1/CHUK/TBK1	1.66080951608045
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	8/1005	41/9376	1.82036160660114	RB1/RAF1/MDM2/BRAF/NRAS/THBS1/MAPK1/VEGFA	1.82398008527423
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	26/1005	180/9376	1.34757324488668	SOCS3/HLA-DQA2/PIK3R1/HLA-DQB1/ZC3HAV1/PTPN11/IFNAR1/HCFC2/HLA-DQA1/ITGA5/AKT3/APAF1/IFNA13/HLA-E/IRF9/PIK3CA/STAT2/TSC1/CASP3/JAK2/C3/PIK3CD/CHUK/TBK1/IFNGR1/POU2F1	1.63140995388668
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	10/1005	56/9376	1.66595593461265	HSPA1A/CASP7/CLK1/HSPA1B/HSPA8/APAF1/HBS1L/CASP3/C3/HSPD1	1.73185508416258
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	29/1005	205/9376	1.31976216478583	STAT3/LYN/PIK3R1/UBE3A/JUN/EP300/PMAIP1/CREB5/YWHAZ/DDX3X/IL6ST/RB1/MDM2/CREBBP/HDAC2/ATF2/HLA-E/GTF2A1/IRF9/PIK3CA/CREB1/CASP3/NRAS/HDAC5/C3/PIK3CD/MAPK1/USP7/DLG1	1.60389398008645
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	9/1005	49/9376	1.71355467560158	SLC18A2/FOSB/GRIN3A/JUN/CREB5/GNAI1/BDNF/ATF2/CREB1	1.73513913828779
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	30/1005	214/9376	1.30785325707909	FOS/MAPK10/PIK3R1/GNAQ/PPP3R1/CUL4B/ITPR2/JUN/GNAI1/CXCR4/GNG12/PAK1/RAF1/AKT3/GNG4/PRKCB/GNB5/IFNA13/HLA-E/PIK3CA/PPP3CB/CASP3/NRAS/CUL5/PAK2/PIK3CD/MAPK1/CHUK/TBK1/AP1S2	1.57846695288794
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	11/1005	66/9376	1.55489220563847	STAT3/GATA3/TGFB2/HLA-DQA2/SMAD3/JUN/RORA/HLA-DQB1/HLA-DQA1/TGFB1/IFNGR1	1.56742132055058
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	14/1005	89/9376	1.46753871093968	HAP1/SLC38A2/GABRE/GNAI1/CACNA1B/GNG12/GNG4/PRKCB/GNB5/GLUL/ADCY2/GABRQ/ADCY6/GABRA5	1.53551779483262
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	5/1005	23/9376	2.0281202682241	PRCP/KLK2/KLK1/AGT/NLN	1.71045782347869
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	13/1005	82/9376	1.47904380536343	HSP90AA1/HSPA2/HSPA1A/HLA-DQA2/HLA-DQB1/HSPA1B/HLA-DQA1/HSPA8/HSP90AB1/NFYB/CANX/HLA-E/CREB1	1.50959628641699
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	4/1005	17/9376	2.19514193737196	CA8/CA2/GLUL/CA5B	1.70887076949544
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	12/1005	75/9376	1.49269651741294	LRP2/GNAQ/ITPR2/CREB5/PLCB1/TTR/PRKCB/ADCY2/ATF2/CANX/CREB1/ADCY6	1.48431234720779
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	15/1005	99/9376	1.41353836876225	PRKAA2/TGFB2/SGCE/ACTG1/CACNB4/DMD/TPM4/ITGA5/ITGB8/ATP2A2/DTNA/AGT/LAMA1/TGFB1/PRKAG2	1.43320933236938
Organismal Systems	Endocrine system	hsa04924	Renin secretion	11/1005	69/9376	1.48728819669767	CLCA1/GNAQ/PPP3R1/ITPR2/PLCB1/GNAI1/AGT/PPP3CB/CREB1/ADCY6/PDE3B	1.40762048468573
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	11/1005	70/9376	1.46604122245913	PRKAA2/SOCS3/STAT3/MAPK10/PTPN11/AKT3/NPY/LEPR/JAK2/CHUK/PRKAG2	1.35603789677533
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	12/1005	78/9376	1.43528511289705	FOS/TGFB2/HLA-DQA2/JUN/HLA-DQB1/HLA-DQA1/PRKCB/JAK2/C3/TGFB1/MAPK1/IFNGR1	1.33753865714341
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	9/1005	55/9376	1.52662143826323	GALC/CERS6/SGPP1/SAMD8/UGCG/HEXB/B4GALT6/CERS2/NEU1	1.35715241463536
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	30/1005	227/9376	1.23295417187192	HGF/FOS/MT-ND1/MAPK10/PIK3R1/GSTA1/JUN/AKR1C2/AKR1C3/AHR/HIF1A/PLD1/NFE2L2/PTPN11/SOS2/EPHX1/GSTA4/SOS1/RAF1/AKT3/BRAF/FOXO3/PIK3CA/ABL1/NRAS/PIK3CD/MAPK1/CHUK/MAP2K4/VEGFA	1.23105258763068
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	21/1005	154/9376	1.27218453188602	PPP2R3A/GNAQ/CREB5/PLCB1/GNAI1/CAMK2D/CACNB4/TPM4/PPP2R5B/AKT3/PPP2R1B/ATP2A2/ADCY2/ATF2/PPP2CA/AGT/PPP2CB/ATP2B2/CREB1/MAPK1/ADCY6	1.18002508709061
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	15/1005	105/9376	1.33276474769012	TGFB2/SGCE/ACTG1/CACNB4/DMD/TPM4/ITGA5/ITGB8/ATP2A2/DTNA/ADCY2/AGT/LAMA1/TGFB1/ADCY6	1.18808816310356
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	14/1005	97/9376	1.34650459044981	FOS/GNAQ/PLCB1/GNAI1/CAMK2D/GNG12/GNG4/PRKCB/GNB5/ADCY2/CREB1/MAPK1/RASD1/ADCY6	1.18856864820259
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	11/1005	73/9376	1.405792953043	MAP1B/EP300/AFF4/PDCD6IP/CXCR4/CCNT2/ELL2/RANBP2/CREBBP/MAP1A/MLLT3	1.20596420812526
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	3/1005	13/9376	2.15292766934558	PRKDC/XRCC5/RAD50	1.4412729128059
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	14/1005	98/9376	1.33276474769012	NR4A1/GNAQ/ITPR2/CREB5/PLCB1/CAMK2D/PRKCB/ADCY2/ATF2/AGT/ATP2B2/CREB1/NR4A2/ADCY6	1.14736913738838
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	21/1005	157/9376	1.24787527331495	FOS/PRKAA2/SOCS3/INSR/MAPK10/PIK3R1/JUN/IL6R/CASP7/AKT3/PPARG/BCL2L11/ITCH/GSK3B/PIK3CA/LEPR/CASP3/TGFB1/PIK3CD/EIF2AK3/PRKAG2	1.08522833092384
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	6/1005	36/9376	1.55489220563847	GALNT3/C1GALT1/C1GALT1C1/GALNT1/GALNTL6/GALNT7	1.15575674022862
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	11/1005	76/9376	1.3503011259492	GNAQ/ITPR2/PLCB1/ACTG1/GNAI1/CAMK2D/CA2/PRKCB/ADCY2/MYLK/ADCY6	1.06239704294876
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	15/1005	109/9376	1.28385594960975	FOS/MAPK10/PIK3R1/JUN/IFNAR1/AKT3/IFNA13/IRF9/PIK3CA/STAT2/PIK3CD/MAPK1/CHUK/TBK1/MAP2K4	1.03281293168968
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	19/1005	144/9376	1.23095632946379	RB1CC1/MAPK10/PIK3R1/GNAQ/ITPR2/GRIN3A/RORA/PLCB1/SP1/PUM1/ATXN1/ATXN3/AKT3/PRKCB/OPA1/ATP2A2/PIK3CA/ULK2/PIK3CD	0.967705512588751
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	8/1005	53/9376	1.40820426171032	GNAQ/PLCB1/ESR1/KLK2/KLK1/PRKCB/ATP2B2/ADCY6	1.03256553557782
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	47/1005	388/9376	1.13010206698466	TUBB2B/APP/MT-ND1/WNT2/WNT5A/RB1CC1/INSR/MAPK10/PIK3R1/GNAQ/TUBA1A/DKK2/AXIN2/PPP3R1/ITPR2/RTN4/WNT16/CASP7/ADAM10/PLCB1/TUBB2A/CTNNB1/FZD3/TUBB4A/RAF1/ADAM17/AKT3/APC/APAF1/ATP2A2/BRAF/GSK3B/CSNK1E/BACE1/PPID/PIK3CA/KIF5B/PPP3CB/CASP3/NRAS/SLC39A10/CSNK1A1/ULK2/PIK3CD/MAPK1/CHUK/EIF2AK3	0.906877287966391
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	11/1005	78/9376	1.31567802015563	INPP4B/PLCB1/PIK3C2A/PPIP5K2/INPP4A/PIKFYVE/PIK3CA/PIK3CD/SACM1L/PIP4K2A/IMPA1	0.970011476750215
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	10/1005	71/9376	1.31399341321561	PIK3R1/FGFR1/HIF1A/RAF1/AKT3/HK1/PIK3CA/NRAS/PIK3CD/MAPK1	0.920177312992404
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	7/1005	48/9376	1.36053067993367	PIK3R1/PLCB1/AKT3/PRKCB/HK1/PIK3CA/PIK3CD	0.867658000550964
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	13/1005	99/9376	1.22506658626062	HRH1/MAPK10/PIK3R1/GNAQ/ITPR2/PLCB1/CAMK2D/PRKCB/ADCY2/PIK3CA/PLA2G4C/PIK3CD/ADCY6	0.780018388133373
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	3/1005	17/9376	1.64635645302897	PAPSS1/TXNRD1/KYAT3	0.924191189947505
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	10/1005	75/9376	1.24391376451078	GADD45G/GADD45A/GADD45B/PMAIP1/CCNG2/MDM2/APAF1/CASP3/THBS1/SIAH1	0.734821943167602
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	7/1005	50/9376	1.30610945273632	CXCL12/HLA-DQA2/HLA-DQB1/CXCR4/HLA-DQA1/CCL28/TGFB1	0.751958781824177
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	13/1005	102/9376	1.18903521607648	CD38/CLCA1/SLC12A2/GNAQ/ITPR2/PLCB1/CA2/PRKCB/ATP2A2/ADCY2/ATP2B2/ADCY6/RAB3D	0.66510353525637
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	7/1005	51/9376	1.28049946346698	SLC12A2/ACTG1/ATP6V1D/ATP6V1C1/ERO1A/TJP1/TJP2	0.695941445404443
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	11/1005	86/9376	1.1932893671179	PCLO/GNAQ/CREB5/PLCB1/CAMK2D/KCNN1/PRKCB/ADCY2/ATF2/CREB1/ADCY6	0.623920608377039
NA	NA	hsa04081	Hormone signaling	26/1005	219/9376	1.10759444785206	DIO2/SLC40A1/TRH/STAT3/GNA14/INSR/PIK3R1/GNAQ/NPR2/PLCB1/ESR1/GNAI1/GNG12/HEPH/IGF1R/SMAD9/GNG4/GNB5/VIPR2/ADCY2/PIK3CA/AGT/LEPR/JAK2/PIK3CD/ADCY6	0.558232747259207
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	7/1005	52/9376	1.25587447378492	INSR/AKR1C3/IGF1R/ADCY2/HSD17B7/PLA2G4C/ADCY6	0.641073020517272
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	10/1005	78/9376	1.19607092741421	PABPC4L/XRN1/BTG1/BTG2/DCP2/HSPD1/PABPC5/CNOT6/PATL1/DDX6	0.602484296357019
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	6/1005	44/9376	1.27218453188602	DYNC1H1/CREB5/CREB1/RAB5B/DYNC1I2/ADCY6	0.627021470359952
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	32/1005	275/9376	1.08559746720941	TUBB2B/LAMC1/MT-ND1/EGR1/HSPA1A/MAPK10/PIK3R1/TUBA1A/PPP3R1/CAV2/ITPR2/GRIN3A/CREB5/TUBB2A/CACNA1B/HSPA1B/NCAM1/TUBB4A/HSPA8/NCAM2/APAF1/FYN/GSK3B/ATF2/PIK3CA/KIF5B/PPP3CB/CREB1/CASP3/PIK3CD/MAPK1/EIF2AK3	0.499186350990335
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	6/1005	45/9376	1.24391376451078	ABCB1/ABCC1/ABCG2/ABCD2/ABCA1/ABCB4	0.568274893622619
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	16/1005	134/9376	1.11395262493503	GNAQ/NPR2/ITPR2/PLCB1/MYH10/RAF1/ARHGEF12/PRKCB/BRAF/ADCY2/AGT/PLA2G4C/MAPK1/ROCK1/MYLK/ADCY6	0.460334737872638
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	29/1005	254/9376	1.06516237709092	HGF/CD38/HRH1/GNA14/MCOLN3/GNAQ/GNAL/PPP3R1/ITPR2/GRIN3A/FGFR1/PTGER3/PLCB1/CXCR4/CACNA1B/CAMK2D/PDGFC/FGF18/PRKCB/FGF7/FGF10/ATP2A2/FGF2/ADCY2/HTR7/PPP3CB/ATP2B2/MYLK/VEGFA	0.364794885871156
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	3/1005	21/9376	1.33276474769012	ALDH3A2/PANK3/CSAD	0.528938356529136
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	53/1005	480/9376	1.03011608623549	TUBB2B/APP/SNCAIP/MT-ND1/WNT2/WNT5A/RB1CC1/HAP1/DNAH14/MAPK10/GNAQ/TUBA1A/DKK2/AXIN2/PPP3R1/ITPR2/WNT16/CASP7/PLCB1/TUBB2A/CACNA1B/CAMK2D/CTNNB1/FZD3/OPTN/TUBB4A/ATXN1/ATXN3/TANK/RAF1/MAP1LC3A/BDNF/APC/PRKCB/APAF1/ATP2A2/BRAF/GSK3B/CSNK1E/PPID/KIF5B/MAP1LC3B/PPP3CB/ALS2/CASP3/NRAS/CSNK1A1/ULK2/MAPK1/TBK1/EIF2AK3/SPG11/SQSTM1	0.234693878308855
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	17/1005	149/9376	1.06442285218204	MT-ND1/MAPK10/GNAQ/ITPR2/PLCB1/GABRE/GNAI1/CACNA1B/GNG12/GNG4/PRKCB/GNB5/ADCY2/GABRQ/MAPK1/ADCY6/GABRA5	0.274652034462234
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	19/1005	168/9376	1.05510542525468	HSP90AA1/STAT3/MAPK10/CAMK2D/IFNAR1/TNFAIP3/FTL/HSP90AB1/TRPM7/IFNA13/GLUL/IRF9/CFLAR/PPID/STAT2/JAK2/PLA2G4C/IFNGR1/SQSTM1	0.249715984017097
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	11/1005	95/9376	1.08024090075936	FOS/CXCL12/TGFB2/HLA-DQA2/JUN/HLA-DQB1/HLA-DQA1/ATP6V1D/ATP6V1C1/TGFB1/VEGFA	0.272358045995301
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	6/1005	50/9376	1.1195223880597	P4HA2/ALDH3A2/SAT2/CKMT2/GATM/SMS	0.293607102043688
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	5/1005	41/9376	1.13772600412571	GRIN3A/GABRE/CACNA1B/GABRQ/GABRA5	0.306217997927145
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	4/1005	32/9376	1.16616915422886	PPP2CA/PPP2CB/ATG5/ULK2	0.32624133213241
Human Diseases	Substance dependence	hsa05034	Alcoholism	21/1005	191/9376	1.0257404079081	SLC18A2/FOSB/GRIN3A/SHC2/CREB5/GNAI1/GNG12/SOS2/SOS1/RAF1/GNG4/BDNF/GNB5/BRAF/HDAC2/ATF2/NPY/CREB1/NRAS/HDAC5/MAPK1	0.124529580843882
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/1005	15/9376	1.24391376451078	HEXB/SLC33A1	0.327567505955403
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	5/1005	44/9376	1.06015377657169	HLA-DQA2/HLA-DQB1/HLA-DQA1/HLA-E/HSPD1	0.138574037151668
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/1005	16/9376	1.16616915422886	B3GALT5/HEXB	0.230490205154169
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	2/1005	17/9376	1.09757096868598	FMO1/CSAD	0.139511610399574
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	6/1005	56/9376	0.999573560767591	MGAT4A/ST6GAL2/ST6GAL1/MGAT5/MAN1C1/MAN2A1	-0.00110897870917551
NA	NA	hsa04082	Neuroactive ligand signaling	21/1005	199/9376	0.984504612615315	SLC18A2/HRH1/GNAQ/OGFRL1/GNAL/GRIN3A/GRIK2/PLCB1/GABRE/GNAI1/GNG12/GRM8/GNG4/PRKCB/GNB5/ADCY2/HTR7/SLC1A2/GABRQ/ADCY6/GABRA5	-0.0765523643396894
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	4/1005	37/9376	1.00857872798171	LAMA4/GNAQ/PLCB1/PRKCB	0.0181156353292922
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	11/1005	105/9376	0.977360814972755	CXCL12/GADD45G/LYN/GADD45A/GADD45B/TNFAIP3/PRKCB/MALT1/CFLAR/ERC1/CHUK	-0.0808299194547741
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	2/1005	18/9376	1.03659480375898	HEXB/NEU1	0.0538448476899315
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	3/1005	28/9376	0.999573560767591	B3GNT2/B3GALT5/B3GNT5	-0.000782991080652794
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	3/1005	28/9376	0.999573560767591	CA2/ATP6V1D/ATP6V1C1	-0.000782991080652794
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	4/1005	38/9376	0.98203718250851	UXS1/RENBP/HK1/HEXB	-0.0384431812269092
Cellular Processes	Cell motility	hsa04814	Motor proteins	20/1005	194/9376	0.961788993178438	TUBB2B/DNAH14/TUBA1A/DYNC1H1/KIF21A/KIF1B/KIF26B/MYO9A/ACTG1/HOOK3/TUBB2A/MYH10/TPM4/TUBB4A/MYO1E/DYNLT3/KIF5B/MYO6/STARD9/DYNC1I2	-0.186337686834302
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	9/1005	88/9376	0.954138398914518	SERPING1/SERPINE2/PLAT/C1S/CFI/CD46/C2/C3/C1R	-0.149764693917163
Human Diseases	Immune disease	hsa05330	Allograft rejection	4/1005	39/9376	0.956856741931369	HLA-DQA2/HLA-DQB1/HLA-DQA1/HLA-E	-0.0935452114567694
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	6/1005	59/9376	0.948747786491272	GSTA1/GSTA4/LANCL1/GCLC/GCLM/SMS	-0.136829765565507
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/1005	19/9376	0.98203718250851	HEXB/HPSE2	-0.0271558212416069
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	5/1005	50/9376	0.932935323383085	HGF/SDC2/TGFB2/THBS1/TGFB1	-0.164744577736801
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	3/1005	30/9376	0.932935323383085	ABCC1/ABCG2/CHUK	-0.127473987725396
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/1005	20/9376	0.932935323383085	LBR/HSD17B7	-0.104026437094397
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	4/1005	41/9376	0.91018080330057	BARD1/TOPBP1/RAD50/BRCA2	-0.199702697855218
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	3/1005	31/9376	0.902840635532017	GLUL/PCCA/CS	-0.187739586737835
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	3/1005	31/9376	0.902840635532017	SEC63/SPCS3/SRP9	-0.187739586737835
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	7/1005	72/9376	0.90702045328911	MAPK10/DDX3X/TANK/IFNA13/ATG5/CHUK/TBK1	-0.274409296285774
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	5/1005	52/9376	0.897053195560658	MYLIP/LRP2/NPC2/SORT1/ABCA1	-0.257924981332854
Organismal Systems	Digestive system	hsa04970	Salivary secretion	9/1005	93/9376	0.902840635532017	CD38/SLC12A2/GNAQ/ITPR2/PLCB1/PRKCB/ADCY2/ATP2B2/ADCY6	-0.32625859569186
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/1005	10/9376	0.932935323383085	PAPSS1	-0.0735185200808905
Human Diseases	Immune disease	hsa05310	Asthma	3/1005	32/9376	0.874626865671642	HLA-DQA2/HLA-DQB1/HLA-DQA1	-0.246146154782537
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	10/1005	104/9376	0.897053195560658	PLD1/AGPAT4/DGKI/ETNPPL/DGKE/CDS1/SAMD8/PLA2G4C/GPCPD1/LPGAT1	-0.365782418063874
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	5/1005	54/9376	0.863829003132486	GCLC/DNMT3A/GCLM/KYAT3/SMS	-0.347701805264748
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	5/1005	54/9376	0.863829003132486	HLA-DQA2/HLA-DQB1/HLA-DQA1/IFNA13/HLA-E	-0.347701805264748
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	4/1005	44/9376	0.84812302125735	MGAT4A/MAN1C1/MAN2A1/HEXB	-0.349873396056617
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	23/1005	235/9376	0.91308563565153	RPS6KA2/PRKAA2/ZNF516/MT-ND1/FGFR1/CREB5/ACTG1/SOS2/DPF3/SOS1/FRS2/SMARCC2/PPARG/SMARCC1/ADCY2/ATF2/TSC1/CREB1/NRAS/SLC25A29/KDM3A/ADCY6/PRKAG2	-0.467529084507101
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	6/1005	66/9376	0.84812302125735	HSD17B6/AKR1C2/AKR1C3/HSD17B11/SRD5A2/HSD17B7	-0.429011638950892
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	4/1005	45/9376	0.829275843007186	HLA-DQA2/HLA-DQB1/HLA-DQA1/HLA-E	-0.397756364215415
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	12/1005	128/9376	0.874626865671642	NT5E/PDE8B/NPR2/PAPSS1/AK3/PDE7A/ENTPD1/ADCY2/FHIT/DCK/ADCY6/PDE3B	-0.494840863142942
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	10/1005	108/9376	0.863829003132486	TPR/DDX39B/RANBP2/IPO9/ACIN1/TNPO1/TMEM33/AHCTF1/IPO5/KPNA4	-0.493155044747507
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	4/1005	48/9376	0.777446102819237	ALDH3A2/PCCA/AACS/ACADM	-0.535601212851607
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	19/1005	205/9376	0.864671763135542	MT-ND1/TGFB2/INSR/SMAD3/MAPK10/PIK3R1/PLCB1/COL3A1/CAMK2D/SP1/TBC1D4/AKT3/PRKCB/ATP2A2/GSK3B/PIK3CA/AGT/TGFB1/PIK3CD	-0.678792453722588
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/1005	14/9376	0.66638237384506	B3GNT2	-0.432821360057912
Organismal Systems	Digestive system	hsa04978	Mineral absorption	5/1005	61/9376	0.764701084740233	SLC40A1/FTL/HEPH/TRPM7/ATP2B2	-0.63881250798984
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	22/1005	238/9376	0.862377189681843	FOS/STAT3/MAPK10/PIK3R1/JUN/IL6R/IFNAR1/C1S/IL6ST/ADAM17/PRKCB/C2/IFNA13/IRF9/PIK3CA/STAT2/C3/PIK3CD/MAPK1/CHUK/TBK1/C1R	-0.745132183778349
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	2/1005	27/9376	0.691063202505989	SCD5/HSD17B4	-0.556991978248245
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	4/1005	51/9376	0.731713979123988	ENPP2/PLD1/PAFAH1B1/PLA2G4C	-0.665638924376191
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/1005	28/9376	0.66638237384506	AKR1C3/PCBD2	-0.612560022097426
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	5/1005	63/9376	0.740424859827845	CUL4B/RAD23B/ERCC6/POLR2B/UVSSA	-0.716256487419062
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	3/1005	42/9376	0.66638237384506	ALDH3A2/TDO2/KYAT3	-0.750792166790539
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	4/1005	54/9376	0.691063202505989	REV3L/POLK/WDR48/BRCA2	-0.7888455300499
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	8/1005	99/9376	0.753887130006533	HLA-DQA2/HLA-DQB1/HLA-DQA1/C1S/CFI/C2/C3/C1R	-0.852958972456655
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	8/1005	100/9376	0.746348258706468	CD44/CD24/CD38/HLA-DQA2/IL6R/HLA-DQB1/HLA-DQA1/ITGA5	-0.883562908603575
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	3/1005	43/9376	0.650885109337036	ALDH3A2/ACADM/ADH5	-0.795008855062143
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/1005	17/9376	0.548785484342991	HSD17B4	-0.645167969148358
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/1005	31/9376	0.601893757021345	ALDH3A2/CSAD	-0.76925473878737
NA	NA	hsa04981	Folate transport and metabolism	2/1005	31/9376	0.601893757021345	ABCC1/ABCG2	-0.76925473878737
Organismal Systems	Digestive system	hsa04976	Bile secretion	7/1005	90/9376	0.725616362631288	ABCB1/EPHX1/CA2/ABCG2/ADCY2/ABCB4/ADCY6	-0.906243954005411
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	6/1005	79/9376	0.708558473455507	SLC18A2/STX3/CACNA1B/ATP6V1D/ATP6V1C1/SLC1A2	-0.901308696147695
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	3/1005	44/9376	0.636092265943012	GTF2I/GTF2A1/TAF7	-0.838320829264901
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	2/1005	33/9376	0.5654153475049	STX3/VAMP7	-0.866499225022287
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	5/1005	70/9376	0.66638237384506	GSTA1/SULT1A1/AKR1C2/EPHX1/GSTA4	-0.970725597429301
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	4/1005	59/9376	0.632498524327515	NT5E/ENTPD1/CTPS2/DCK	-0.981131102809466
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	27/1005	308/9376	0.817832913355302	TUBB2B/MT-ND1/RB1CC1/HAP1/DNAH14/MAPK10/GNAQ/TUBA1A/EP300/CREB5/PLCB1/TUBB2A/CACNA1B/SP1/TUBB4A/BDNF/PPARG/REST/APAF1/CREBBP/HDAC2/KIF5B/CREB1/SLC1A2/CASP3/ULK2/POLR2B	-1.12634001517806
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	6/1005	83/9376	0.674411077144399	CASP7/IFI16/IFNA13/CASP3/CHUK/TBK1	-1.03231133659489
NA	NA	hsa03272	Virion - Hepatitis viruses	3/1005	48/9376	0.583084577114428	LAMP2/PDCD6IP/OCLN	-1.0033542839858
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/1005	35/9376	0.533105899076048	HK1/PFKFB4	-0.958816990010811
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/1005	36/9376	0.518297401879491	PGM2L1/HK1	-1.00331383087788
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	12/1005	154/9376	0.726962589649157	HSD17B6/RDH11/ALDH3A2/RFK/AK3/PANK3/NMNAT2/NADK/GCLC/TDO2/GCLM/CTPS2	-1.18372264469152
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	4/1005	63/9376	0.592339887862276	HPGD/AKR1C3/PTGIS/PLA2G4C	-1.12487351364609
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/1005	22/9376	0.424061510628675	ALDH3A2	-0.937062932290084
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/1005	37/9376	0.504289363990857	GLUL/ASNS	-1.04678842014057
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	2/1005	37/9376	0.504289363990857	UXS1/HK1	-1.04678842014057
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	5/1005	76/9376	0.613773239067819	SLC27A6/FABP5/PPARG/SCD5/ACADM	-1.17135269722636
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/1005	23/9376	0.405624053644819	GLUL	-0.988848307880231
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/1005	23/9376	0.405624053644819	B3GALNT2	-0.988848307880231
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/1005	23/9376	0.405624053644819	NUS1	-0.988848307880231
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/1005	23/9376	0.405624053644819	CA2	-0.988848307880231
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	4/1005	65/9376	0.574114045158821	AGPAT4/ALDH3A2/DGKI/DGKE	-1.19380070481096
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	31/1005	368/9376	0.785896603936838	TUBB2B/MT-ND1/RB1CC1/HAP1/DNAH14/TUBA1A/PPP3R1/ACTG1/SETX/TUBB2A/HNRNPA2B1/OPTN/TUBB4A/TPR/TANK/MAP1LC3A/RANBP2/APAF1/KIF5B/MAP1LC3B/PPP3CB/ALS2/SLC1A2/CASP3/ANXA7/UBQLN1/ULK2/TBK1/EIF2AK3/SPG11/SQSTM1	-1.4518216710229
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4/1005	68/9376	0.548785484342991	ALDH1A1/HSD17B6/RDH11/ADH5	-1.29386608639763
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/1005	26/9376	0.358821278224263	PLA2G4C	-1.13433143622331
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/1005	26/9376	0.358821278224263	ABCC1	-1.13433143622331
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	24/1005	298/9376	0.751357307422618	IL32/IL17RB/CXCL12/TGFB2/OSMR/IL6R/IL13RA1/CXCR4/TNFRSF12A/BMPR2/IFNAR1/IL6ST/TNFRSF21/LIFR/IFNA13/CCR6/ACVR2A/LEPR/CCL28/TGFB1/IL31RA/CLCF1/IFNGR1/LIF	-1.51136284394956
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	3/1005	57/9376	0.491018591254255	SCD5/ACADM/HSD17B4	-1.3354717005691
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/1005	27/9376	0.345531601252994	AACS	-1.17996189212819
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	2/1005	44/9376	0.424061510628675	TDG/PARP2	-1.32676826247319
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	5/1005	85/9376	0.548785484342991	NT5E/AK3/ENTPD1/CTPS2/DCK	-1.44790908612949
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4/1005	73/9376	0.511197437470183	GSTA1/FMO1/GSTA4/ADH5	-1.45265803861409
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	6/1005	100/9376	0.559761194029851	CXCL12/IL6R/CXCR4/IL6ST/CCR6/CCL28	-1.53351472337426
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/1005	46/9376	0.405624053644819	FTL/HEPH	-1.40016532391684
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/1005	30/9376	0.310978441127695	CS	-1.30966598467229
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/1005	30/9376	0.310978441127695	PLA2G4C	-1.30966598467229
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	2/1005	47/9376	0.3969937546311	ALDH3A2/ADH5	-1.43592974102202
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/1005	31/9376	0.300946878510672	H6PD	-1.35076989083691
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/1005	31/9376	0.300946878510672	ALDH3A2	-1.35076989083691
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/1005	32/9376	0.291542288557214	HK1	-1.39092112861243
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/1005	32/9376	0.291542288557214	PCCA	-1.39092112861243
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4/1005	79/9376	0.472372315637005	GSTA1/EPHX1/GSTA4/ADH5	-1.6317352776837
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/1005	33/9376	0.28270767375245	CS	-1.43017762187297
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/1005	34/9376	0.274392742171495	POLR2B	-1.46859194969481
NA	NA	hsa04382	Cornified envelope formation	15/1005	217/9376	0.644886168237155	LAMA3/PPP2R3A/COL7A1/JUP/PKP2/COL4A4/PPP2R5B/PPP2R1B/DSG2/DST/PPP2CA/PPP2CB/TJP1/UGCG/OCLN	-1.8338061463929
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	3/1005	67/9376	0.417732234350635	ALDH3A2/HK1/ADH5	-1.65725230807812
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	19/1005	268/9376	0.661409371055172	SLC18A2/TUBB2B/SNCAIP/MT-ND1/DUSP1/MAPK10/GNAL/TUBA1A/ITPR2/TUBB2A/GNAI1/CAMK2D/NFE2L2/TUBB4A/APAF1/KIF5B/CASP3/SLC39A10/EIF2AK3	-1.94854669762909
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/1005	37/9376	0.252144681995428	ADH5	-1.5792404478755
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	4/1005	87/9376	0.428935780865786	CACNB4/TPM4/SLC9A7/ATP2A2	-1.85412962325412
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/1005	39/9376	0.239214185482842	ALDH1L2	-1.64957105879918
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	3/1005	75/9376	0.373174129353234	GLUL/ASNS/CS	-1.88839447097306
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	12/1005	195/9376	0.574114045158821	PIK3R1/PLCB1/ACTG1/RAF1/AKT3/PRKCB/HDAC2/PIK3CA/HDAC5/C3/PIK3CD/MAPK1	-2.08231116598893
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/1005	41/9376	0.227545200825143	GATM	-1.71746478520231
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/1005	43/9376	0.216961703112345	ABCA1	-1.78314473695551
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	1/1005	46/9376	0.20281202682241	PSME4	-1.87792753648851
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	3/1005	83/9376	0.337205538572199	FAR1/ABCD2/HSD17B4	-2.10145428279104
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	7/1005	143/9376	0.456681626830881	HLA-DQA2/HLA-DQB1/HLA-DQA1/C1S/C2/C3/C1R	-2.26845929481986
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	5/1005	116/9376	0.402127294561674	HK1/PCCA/CS/H6PD/ADH5	-2.24497870857438
Organismal Systems	Sensory system	hsa04742	Taste transduction	3/1005	86/9376	0.325442554668518	PLCB1/ADCY6/GABRA5	-2.177410469867
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	2/1005	82/9376	0.227545200825143	GSTA1/GSTA4	-2.43421349614299
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	23/1005	370/9376	0.579932768589485	TRH/HRH1/OGFRL1/GRIN3A/PTGER3/GRID2/GRIK2/GABRE/LPAR2/S1PR3/GRM8/VIPR2/NMUR2/TMEM97/HTR7/AGT/NPY/LEPR/GABRQ/VGF/C3/GABRA5/RLN1	-2.85649648026137
Genetic Information Processing	Transcription	hsa03040	Spliceosome	11/1005	243/9376	0.422316401531437	DDX5/HSPA1A/HNRNPU/SF3B1/WBP11/TRA2A/HSPA1B/HSPA8/DDX39B/ACIN1/CDC5L	-3.16130532859469
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	3/1005	138/9376	0.20281202682241	MT-ND1/ATP6V1D/ATP6V1C1	-3.26882221239033
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	2/1005	183/9376	0.101960144632031	XRN1/EFL1	-4.25081812975663
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	5/1005	449/9376	0.103890347815488	GNAL/SLC24A4/CAMK2D/RGS2/GRK3	-6.74235408552352