ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 84/2080 349/18639 0.240687679083095 2.15681617809125 4.99484116336676e-12 6.13366494861438e-09 GO:0140297 DNA-binding transcription factor binding 103/2080 488/18639 0.211065573770492 1.8913707834174 9.42623948625712e-11 5.78771104456187e-08 GO:0016922 nuclear receptor binding 39/2080 137/18639 0.284671532846715 2.55095802919708 2.13595982841033e-08 8.74319556429294e-06 GO:0030695 GTPase regulator activity 95/2080 489/18639 0.194274028629857 1.74090077866918 4.0758920975145e-08 1.1087778215748e-05 GO:0060589 nucleoside-triphosphatase regulator activity 95/2080 490/18639 0.193877551020408 1.73734791993721 4.5145676774218e-08 1.1087778215748e-05 GO:0005201 extracellular matrix structural constituent 43/2080 168/18639 0.255952380952381 2.2936040521978 1.23194125825047e-07 2.52137310855262e-05 GO:0003712 transcription coregulator activity 94/2080 495/18639 0.18989898989899 1.7016958041958 1.45985037338658e-07 2.56099465502674e-05 GO:0046332 SMAD binding 26/2080 79/18639 0.329113924050633 2.94920886075949 2.07513581899146e-07 3.18533348215189e-05 GO:0008013 beta-catenin binding 31/2080 106/18639 0.292452830188679 2.62068668359942 3.00879456687133e-07 4.10533303124221e-05 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 91/2080 484/18639 0.18801652892562 1.68482696280992 3.64970836133462e-07 4.48184186771892e-05 GO:0045296 cadherin binding 68/2080 334/18639 0.203592814371257 1.82440695532013 5.9413512643254e-07 6.63270850235599e-05 GO:0001216 DNA-binding transcription activator activity 91/2080 491/18639 0.185336048879837 1.66080702647658 7.00232268182817e-07 7.16571021107083e-05 GO:0001217 DNA-binding transcription repressor activity 59/2080 278/18639 0.212230215827338 1.90180720807969 7.89582244507244e-07 7.45851535580689e-05 GO:0106310 protein serine kinase activity 70/2080 361/18639 0.193905817174515 1.7376012145749 2.60490673858963e-06 0.000228487533927719 GO:0140996 histone H3 kinase activity 69/2080 357/18639 0.19327731092437 1.73196913380737 3.44599047724153e-06 0.000265715035192806 GO:0035091 phosphatidylinositol binding 58/2080 284/18639 0.204225352112676 1.83007516251354 3.52972527518453e-06 0.000265715035192806 GO:0004674 protein serine/threonine kinase activity 80/2080 433/18639 0.184757505773672 1.65562266832475 3.67846547091018e-06 0.000265715035192806 GO:0035173 histone kinase activity 69/2080 360/18639 0.191666666666667 1.71753605769231 4.65649803551536e-06 0.000313662785465224 GO:0141003 histone H2AX kinase activity 68/2080 354/18639 0.192090395480226 1.72133311603651 5.03477616727034e-06 0.000313662785465224 GO:0019787 ubiquitin-like protein transferase activity 86/2080 479/18639 0.179540709812109 1.60887465874418 5.25255530267988e-06 0.000313662785465224 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 55/2080 268/18639 0.205223880597015 1.83902303386912 5.36394014232061e-06 0.000313662785465224 GO:0001221 transcription coregulator binding 30/2080 115/18639 0.260869565217391 2.33766722408027 6.28816156997887e-06 0.000350993745815184 GO:0031267 small GTPase binding 57/2080 283/18639 0.201413427561837 1.80487734438706 6.63898415471161e-06 0.000354464023564603 GO:0005096 GTPase activator activity 55/2080 271/18639 0.202952029520295 1.8186648453023 7.57358060873643e-06 0.000387514874480347 GO:0004842 ubiquitin-protein transferase activity 81/2080 449/18639 0.180400890868597 1.6165827908172 8.1461244736339e-06 0.000400137634144897 GO:0003779 actin binding 80/2080 443/18639 0.18058690744921 1.6182496961278 8.89003398866001e-06 0.000419883143772096 GO:0051020 GTPase binding 61/2080 315/18639 0.193650793650794 1.73531593406593 1.1686609257284e-05 0.000531524302516473 GO:0015631 tubulin binding 71/2080 385/18639 0.184415584415584 1.65255869130869 1.35662530288289e-05 0.000594977097121497 GO:0070717 poly-purine tract binding 13/2080 32/18639 0.40625 3.6404296875 1.7916666513554e-05 0.000758678154436009 GO:0016755 aminoacyltransferase activity 86/2080 496/18639 0.173387096774194 1.55373177729529 2.06961196713071e-05 0.000798810100400456 GO:0035403 histone H3T6 kinase activity 50/2080 247/18639 0.202429149797571 1.81397928994083 2.07084266139838e-05 0.000798810100400456 GO:0051219 phosphoprotein binding 25/2080 93/18639 0.268817204301075 2.4088864764268 2.08158983817708e-05 0.000798810100400456 GO:0004679 AMP-activated protein kinase activity 50/2080 248/18639 0.201612903225806 1.8066648573201 2.3176959200447e-05 0.000817459420047532 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 49/2080 243/18639 0.201646090534979 1.80696225071225 2.77139394066556e-05 0.000817459420047532 GO:0003714 transcription corepressor activity 43/2080 204/18639 0.21078431372549 1.8888503959276 2.79952948248485e-05 0.000817459420047532 GO:0004676 3-phosphoinositide-dependent protein kinase activity 49/2080 245/18639 0.2 1.79221153846154 3.46155454743255e-05 0.000817459420047532 GO:0004711 ribosomal protein S6 kinase activity 49/2080 245/18639 0.2 1.79221153846154 3.46155454743255e-05 0.000817459420047532 GO:0035175 histone H3S10 kinase activity 49/2080 245/18639 0.2 1.79221153846154 3.46155454743255e-05 0.000817459420047532 GO:0035979 histone H2AXS139 kinase activity 49/2080 245/18639 0.2 1.79221153846154 3.46155454743255e-05 0.000817459420047532 GO:0044022 histone H3S28 kinase activity 49/2080 245/18639 0.2 1.79221153846154 3.46155454743255e-05 0.000817459420047532 GO:0044023 histone H4S1 kinase activity 49/2080 245/18639 0.2 1.79221153846154 3.46155454743255e-05 0.000817459420047532 GO:0044024 histone H2AS1 kinase activity 49/2080 245/18639 0.2 1.79221153846154 3.46155454743255e-05 0.000817459420047532 GO:0044025 histone H2BS14 kinase activity 49/2080 245/18639 0.2 1.79221153846154 3.46155454743255e-05 0.000817459420047532 GO:0072354 histone H3T3 kinase activity 49/2080 245/18639 0.2 1.79221153846154 3.46155454743255e-05 0.000817459420047532 GO:0072371 histone H2AS121 kinase activity 49/2080 245/18639 0.2 1.79221153846154 3.46155454743255e-05 0.000817459420047532 GO:0072518 Rho-dependent protein serine/threonine kinase activity 49/2080 245/18639 0.2 1.79221153846154 3.46155454743255e-05 0.000817459420047532 GO:0140823 histone H2BS36 kinase activity 49/2080 245/18639 0.2 1.79221153846154 3.46155454743255e-05 0.000817459420047532 GO:0140855 histone H3S57 kinase activity 49/2080 245/18639 0.2 1.79221153846154 3.46155454743255e-05 0.000817459420047532 GO:0140995 histone H2A kinase activity 49/2080 245/18639 0.2 1.79221153846154 3.46155454743255e-05 0.000817459420047532 GO:0140997 histone H4 kinase activity 49/2080 245/18639 0.2 1.79221153846154 3.46155454743255e-05 0.000817459420047532 GO:0140998 histone H2B kinase activity 49/2080 245/18639 0.2 1.79221153846154 3.46155454743255e-05 0.000817459420047532 GO:1990244 histone H2AT120 kinase activity 49/2080 245/18639 0.2 1.79221153846154 3.46155454743255e-05 0.000817459420047532 GO:0048156 tau protein binding 15/2080 43/18639 0.348837209302326 3.12595035778175 3.54512381882301e-05 0.000821398499908425 GO:0005543 phospholipid binding 85/2080 497/18639 0.17102615694165 1.53257525924779 3.84777876633055e-05 0.00084705547309304 GO:0004677 DNA-dependent protein kinase activity 49/2080 246/18639 0.199186991869919 1.78492612570356 3.86279368837217e-05 0.00084705547309304 GO:0140857 histone H3T45 kinase activity 49/2080 246/18639 0.199186991869919 1.78492612570356 3.86279368837217e-05 0.00084705547309304 GO:0035402 histone H3T11 kinase activity 49/2080 247/18639 0.198380566801619 1.77769970414201 4.30625631625965e-05 0.000927733816906464 GO:0005085 guanyl-nucleotide exchange factor activity 45/2080 230/18639 0.195652173913043 1.7532504180602 0.000121414767938392 0.00257064370738526 GO:0017124 SH3 domain binding 27/2080 115/18639 0.234782608695652 2.10390050167224 0.000129547783391065 0.00269635047464792 GO:0019209 kinase activator activity 32/2080 148/18639 0.216216216216216 1.93752598752599 0.000172295932316557 0.00352632341474553 GO:0140463 chromatin-protein adaptor activity 16/2080 54/18639 0.296296296296296 2.65512820512821 0.000182378633217325 0.0036714911736209 GO:0030020 extracellular matrix structural constituent conferring tensile strength 14/2080 44/18639 0.318181818181818 2.85124562937063 0.000198743148403039 0.00393639655224083 GO:0008187 poly-pyrimidine tract binding 11/2080 30/18639 0.366666666666667 3.28572115384615 0.000235536625284299 0.00451935899764248 GO:0035925 mRNA 3'-UTR AU-rich region binding 11/2080 30/18639 0.366666666666667 3.28572115384615 0.000235536625284299 0.00451935899764248 GO:1905394 retromer complex binding 6/2080 10/18639 0.6 5.37663461538462 0.000270203322367797 0.00510476430565623 GO:0030295 protein kinase activator activity 30/2080 139/18639 0.215827338129496 1.93404122855562 0.000279770365514232 0.00515945471069331 GO:0044389 ubiquitin-like protein ligase binding 57/2080 322/18639 0.177018633540373 1.58627418776875 0.000281501193498739 0.00515945471069331 GO:0008143 poly(A) binding 10/2080 26/18639 0.384615384615385 3.44656065088757 0.000287698355058507 0.00519549382370363 GO:0042826 histone deacetylase binding 28/2080 127/18639 0.220472440944882 1.97566626287099 0.000304168599056345 0.00541331941508973 GO:0031625 ubiquitin protein ligase binding 54/2080 302/18639 0.178807947019868 1.60230832908813 0.000311230451012938 0.00545987134062698 GO:0140030 modification-dependent protein binding 35/2080 173/18639 0.202312138728324 1.81293074699867 0.000342113832647398 0.00591712375339444 GO:0005545 1-phosphatidylinositol binding 7/2080 14/18639 0.5 4.48052884615385 0.000359293005144933 0.00612794180997192 GO:0008017 microtubule binding 50/2080 276/18639 0.181159420289855 1.62338001672241 0.000372581994889077 0.0062675436948464 GO:0008266 poly(U) RNA binding 10/2080 27/18639 0.37037037037037 3.31891025641026 0.000411519351256713 0.00682899680193572 GO:0044325 transmembrane transporter binding 29/2080 136/18639 0.213235294117647 1.91081377262443 0.000433270861246155 0.00709408823480372 GO:0061659 ubiquitin-like protein ligase activity 63/2080 372/18639 0.169354838709677 1.51759848014888 0.000480729858114183 0.00776758244426601 GO:0045294 alpha-catenin binding 6/2080 11/18639 0.545454545454545 4.88784965034965 0.000538235637233219 0.00858380990288821 GO:0070063 RNA polymerase binding 16/2080 59/18639 0.271186440677966 2.43011734028683 0.000552788010233874 0.0087028676482974 GO:0046966 nuclear thyroid hormone receptor binding 10/2080 28/18639 0.357142857142857 3.20037774725275 0.000576594054602196 0.00896275315255059 GO:0140776 protein-containing complex destabilizing activity 7/2080 15/18639 0.466666666666667 4.18182692307692 0.000608899464759293 0.00934660678405515 GO:0001223 transcription coactivator binding 13/2080 44/18639 0.295454545454545 2.64758522727273 0.000742144283975684 0.0112512738360758 GO:0098632 cell-cell adhesion mediator activity 15/2080 55/18639 0.272727272727273 2.44392482517482 0.000763921960130643 0.0114401971590296 GO:0035259 nuclear glucocorticoid receptor binding 6/2080 12/18639 0.5 4.48052884615385 0.000974917660201368 0.0144240829726178 GO:0042393 histone binding 44/2080 247/18639 0.178137651821862 1.59630177514793 0.00115337682143169 0.0166966116822717 GO:0031072 heat shock protein binding 27/2080 131/18639 0.206106870229008 1.84693555490311 0.00115571009201392 0.0166966116822717 GO:0019887 protein kinase regulator activity 45/2080 255/18639 0.176470588235294 1.58136312217195 0.00124473509868408 0.0177736593160935 GO:0008201 heparin binding 33/2080 172/18639 0.191860465116279 1.71927269677996 0.00129652489008169 0.0183003743105784 GO:0140034 methylation-dependent protein binding 18/2080 76/18639 0.236842105263158 2.12235576923077 0.00146289314100456 0.0204140088312909 GO:0003727 single-stranded RNA binding 20/2080 89/18639 0.224719101123595 2.01372082973207 0.00163727657872599 0.0224303746310484 GO:0061630 ubiquitin protein ligase activity 58/2080 353/18639 0.164305949008499 1.47235508825452 0.00164391996481625 0.0224303746310484 GO:0008093 cytoskeletal anchor activity 8/2080 22/18639 0.363636363636364 3.25856643356643 0.00179496031585078 0.0242221018446677 GO:0019902 phosphatase binding 35/2080 190/18639 0.184210526315789 1.65072115384615 0.00196070924321473 0.0261151092132504 GO:0001098 basal transcription machinery binding 15/2080 60/18639 0.25 2.24026442307692 0.00199903930459734 0.0261151092132504 GO:0001099 basal RNA polymerase II transcription machinery binding 15/2080 60/18639 0.25 2.24026442307692 0.00199903930459734 0.0261151092132504 GO:1901981 phosphatidylinositol phosphate binding 34/2080 185/18639 0.183783783783784 1.64689708939709 0.00234435719474448 0.0303039014225918 GO:0097718 disordered domain specific binding 9/2080 28/18639 0.321428571428571 2.88033997252747 0.00251956639710272 0.0322294534962723 GO:0042043 neurexin family protein binding 6/2080 14/18639 0.428571428571429 3.8404532967033 0.00260081678061139 0.0329258041916576 GO:0019207 kinase regulator activity 48/2080 287/18639 0.167247386759582 1.49871348164031 0.00274916940061471 0.0344487757546415 GO:0030145 manganese ion binding 16/2080 68/18639 0.235294117647059 2.10848416289593 0.00281476703545629 0.0349144840357609 GO:0004713 protein tyrosine kinase activity 27/2080 140/18639 0.192857142857143 1.72820398351648 0.00315330143597608 0.0387225416337862 GO:1990380 K48-linked deubiquitinase activity 7/2080 19/18639 0.368421052631579 3.30144230769231 0.00318867823828906 0.0387692760061284 GO:0001091 RNA polymerase II general transcription initiation factor binding 8/2080 24/18639 0.333333333333333 2.98701923076923 0.00336851962563251 0.0405543343164385 GO:0030331 nuclear estrogen receptor binding 11/2080 40/18639 0.275 2.46429086538462 0.00348844649287232 0.0415904106140506 GO:0031490 chromatin DNA binding 25/2080 128/18639 0.1953125 1.75020658052885 0.00369170150750726 0.0435904754924896 GO:0097110 scaffold protein binding 16/2080 70/18639 0.228571428571429 2.04824175824176 0.00383495289250321 0.044850687161847 GO:0140566 histone reader activity 10/2080 35/18639 0.285714285714286 2.5603021978022 0.00389471894201506 0.0451199515169292 GO:0003713 transcription coactivator activity 43/2080 256/18639 0.16796875 1.50517765925481 0.00407921763834951 0.0466279041572811 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 18/2080 83/18639 0.216867469879518 1.94336190917516 0.00410082544705729 0.0466279041572811 GO:0042169 SH2 domain binding 11/2080 41/18639 0.268292682926829 2.40418621013133 0.00429534016014519 0.0483915386849384 GO:0042974 nuclear retinoic acid receptor binding 8/2080 25/18639 0.32 2.86753846153846 0.00447590726224581 0.0499674010730714 GO:0001784 phosphotyrosine residue binding 12/2080 47/18639 0.25531914893617 2.28792962356792 0.00453103046873699 0.0501270758162975 GO:0045309 protein phosphorylated amino acid binding 14/2080 59/18639 0.23728813559322 2.12635267275098 0.00464130445262655 0.050888588105584 GO:0035198 miRNA binding 11/2080 42/18639 0.261904761904762 2.34694368131868 0.00524379969356796 0.0569857170239067 GO:0051015 actin filament binding 36/2080 209/18639 0.172248803827751 1.54353146853147 0.00539673657589859 0.0581332676772234 GO:0140328 floppase activity 6/2080 16/18639 0.375 3.36039663461538 0.00569885570731734 0.0608538679007452 GO:0005160 transforming growth factor beta receptor binding 8/2080 26/18639 0.307692307692308 2.75724852071006 0.00584274034224963 0.0613238046177995 GO:0070412 R-SMAD binding 8/2080 26/18639 0.307692307692308 2.75724852071006 0.00584274034224963 0.0613238046177995 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 7/2080 21/18639 0.333333333333333 2.98701923076923 0.00602557128796532 0.0621798448875749 GO:0051010 microtubule plus-end binding 7/2080 21/18639 0.333333333333333 2.98701923076923 0.00602557128796532 0.0621798448875749 GO:0001222 transcription corepressor binding 12/2080 49/18639 0.244897959183673 2.19454474097331 0.00648845782188393 0.065572674284186 GO:0060590 ATPase regulator activity 12/2080 49/18639 0.244897959183673 2.19454474097331 0.00648845782188393 0.065572674284186 GO:0019783 ubiquitin-like protein peptidase activity 24/2080 127/18639 0.188976377952756 1.69342822531799 0.0067162584388974 0.065572674284186 GO:0035064 methylated histone binding 16/2080 74/18639 0.216216216216216 1.93752598752599 0.0067854987730657 0.065572674284186 GO:0003924 GTPase activity 52/2080 331/18639 0.157099697885196 1.40777945619335 0.00692284875895411 0.065572674284186 GO:0005095 GTPase inhibitor activity 5/2080 12/18639 0.416666666666667 3.73377403846154 0.00694674349939594 0.065572674284186 GO:0035497 cAMP response element binding 5/2080 12/18639 0.416666666666667 3.73377403846154 0.00694674349939594 0.065572674284186 GO:0070008 serine-type exopeptidase activity 5/2080 12/18639 0.416666666666667 3.73377403846154 0.00694674349939594 0.065572674284186 GO:1990247 N6-methyladenosine-containing RNA reader activity 5/2080 12/18639 0.416666666666667 3.73377403846154 0.00694674349939594 0.065572674284186 GO:0032934 sterol binding 15/2080 68/18639 0.220588235294118 1.97670390271493 0.00711055439881017 0.065572674284186 GO:0033192 calmodulin-dependent protein phosphatase activity 17/2080 81/18639 0.209876543209877 1.88071581196581 0.00731551822225853 0.065572674284186 GO:0140791 histone H2AXS140 phosphatase activity 17/2080 81/18639 0.209876543209877 1.88071581196581 0.00731551822225853 0.065572674284186 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 17/2080 81/18639 0.209876543209877 1.88071581196581 0.00731551822225853 0.065572674284186 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 17/2080 81/18639 0.209876543209877 1.88071581196581 0.00731551822225853 0.065572674284186 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 17/2080 81/18639 0.209876543209877 1.88071581196581 0.00731551822225853 0.065572674284186 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 17/2080 81/18639 0.209876543209877 1.88071581196581 0.00731551822225853 0.065572674284186 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 17/2080 81/18639 0.209876543209877 1.88071581196581 0.00731551822225853 0.065572674284186 GO:1990439 MAP kinase serine/threonine phosphatase activity 17/2080 81/18639 0.209876543209877 1.88071581196581 0.00731551822225853 0.065572674284186 GO:0001046 core promoter sequence-specific DNA binding 11/2080 44/18639 0.25 2.24026442307692 0.00763137975394954 0.0675304427023658 GO:0016887 ATP hydrolysis activity 63/2080 417/18639 0.151079136690647 1.35382885998893 0.00771063352507412 0.0675304427023658 GO:0003725 double-stranded RNA binding 16/2080 75/18639 0.213333333333333 1.91169230769231 0.00775390262299151 0.0675304427023658 GO:0019003 GDP binding 16/2080 75/18639 0.213333333333333 1.91169230769231 0.00775390262299151 0.0675304427023658 GO:0038191 neuropilin binding 6/2080 17/18639 0.352941176470588 3.16272624434389 0.00798680161387078 0.067750508064652 GO:0046965 nuclear retinoid X receptor binding 6/2080 17/18639 0.352941176470588 3.16272624434389 0.00798680161387078 0.067750508064652 GO:1990226 histone methyltransferase binding 6/2080 17/18639 0.352941176470588 3.16272624434389 0.00798680161387078 0.067750508064652 GO:0140517 protein-RNA adaptor activity 7/2080 22/18639 0.318181818181818 2.85124562937063 0.00799985640828545 0.067750508064652 GO:0035591 signaling adaptor activity 24/2080 129/18639 0.186046511627907 1.66717352415027 0.00817059274842317 0.0678955726925183 GO:0002039 p53 binding 15/2080 69/18639 0.217391304347826 1.94805602006689 0.00817114268490019 0.0678955726925183 GO:0140789 histone phosphatase activity 25/2080 136/18639 0.183823529411765 1.64725325226244 0.00822168821989465 0.0678955726925183 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 17/2080 82/18639 0.207317073170732 1.8577802532833 0.00829343314648025 0.0678955726925183 GO:0033549 MAP kinase phosphatase activity 17/2080 82/18639 0.207317073170732 1.8577802532833 0.00829343314648025 0.0678955726925183 GO:0030296 protein tyrosine kinase activator activity 9/2080 33/18639 0.272727272727273 2.44392482517482 0.00843059229982126 0.0681103114748718 GO:0140416 transcription regulator inhibitor activity 9/2080 33/18639 0.272727272727273 2.44392482517482 0.00843059229982126 0.0681103114748718 GO:0030165 PDZ domain binding 17/2080 83/18639 0.204819277108434 1.83539735866543 0.00937334725087706 0.0752318328371048 GO:0045499 chemorepellent activity 8/2080 28/18639 0.285714285714286 2.5603021978022 0.00949907563707928 0.0757458758593075 GO:0019208 phosphatase regulator activity 22/2080 117/18639 0.188034188034188 1.68498520710059 0.00972986925578801 0.077085673845856 GO:0043560 insulin receptor substrate binding 5/2080 13/18639 0.384615384615385 3.44656065088757 0.0102633558527791 0.0797683606785614 GO:0061459 L-arginine transmembrane transporter activity 5/2080 13/18639 0.384615384615385 3.44656065088757 0.0102633558527791 0.0797683606785614 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 5/2080 13/18639 0.384615384615385 3.44656065088757 0.0102633558527791 0.0797683606785614 GO:0017018 myosin phosphatase activity 17/2080 84/18639 0.202380952380952 1.81354739010989 0.0105624182806255 0.0815764128843275 GO:0140662 ATP-dependent protein folding chaperone 10/2080 40/18639 0.25 2.24026442307692 0.0107384055835044 0.0823750567310347 GO:0070851 growth factor receptor binding 25/2080 139/18639 0.179856115107914 1.61170102379635 0.01080530219976 0.0823750567310347 GO:0098641 cadherin binding involved in cell-cell adhesion 6/2080 18/18639 0.333333333333333 2.98701923076923 0.0108670677446479 0.0823750567310347 GO:0010484 histone H3 acetyltransferase activity 8/2080 29/18639 0.275862068965517 2.47201591511936 0.0118619200034672 0.0893646488604771 GO:0005518 collagen binding 15/2080 72/18639 0.208333333333333 1.86688701923077 0.0121221458669239 0.0907682629547714 GO:0004386 helicase activity 27/2080 155/18639 0.174193548387097 1.56095843672457 0.0125905275286231 0.0931430113731511 GO:0010485 histone H4 acetyltransferase activity 9/2080 35/18639 0.257142857142857 2.30427197802198 0.0125909933940905 0.0931430113731511 GO:0051087 protein-folding chaperone binding 24/2080 134/18639 0.17910447761194 1.60496555683123 0.0129533529218833 0.0952498047189982 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 17/2080 86/18639 0.197674418604651 1.77137186940966 0.0132974121313551 0.0956013952276901 GO:0030215 semaphorin receptor binding 7/2080 24/18639 0.291666666666667 2.61364182692308 0.0133125721367549 0.0956013952276901 GO:0035035 histone acetyltransferase binding 7/2080 24/18639 0.291666666666667 2.61364182692308 0.0133125721367549 0.0956013952276901 GO:0140033 acetylation-dependent protein binding 7/2080 24/18639 0.291666666666667 2.61364182692308 0.0133125721367549 0.0956013952276901 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 6/2080 19/18639 0.315789473684211 2.82980769230769 0.0144109398245059 0.102887407584263 GO:0008234 cysteine-type peptidase activity 31/2080 187/18639 0.165775401069519 1.4855229329494 0.0157782389823018 0.111998135666281 GO:0140313 molecular sequestering activity 12/2080 55/18639 0.218181818181818 1.95513986013986 0.0165072617663345 0.116499525569303 GO:0005548 phospholipid transporter activity 14/2080 68/18639 0.205882352941176 1.84492364253394 0.0166440418436202 0.116793619336947 GO:0019211 phosphatase activator activity 7/2080 25/18639 0.28 2.50909615384615 0.0167490529212862 0.116862710155338 GO:0005522 profilin binding 4/2080 10/18639 0.4 3.58442307692308 0.0186667175765798 0.128059939575642 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 4/2080 10/18639 0.4 3.58442307692308 0.0186667175765798 0.128059939575642 GO:0042975 peroxisome proliferator activated receptor binding 4/2080 10/18639 0.4 3.58442307692308 0.0186667175765798 0.128059939575642 GO:0005539 glycosaminoglycan binding 38/2080 242/18639 0.15702479338843 1.40710823267641 0.0189005052039127 0.12894344661336 GO:0004721 phosphoprotein phosphatase activity 29/2080 175/18639 0.165714285714286 1.48497527472527 0.0191467823461084 0.129901926635476 GO:0098631 cell adhesion mediator activity 15/2080 76/18639 0.197368421052632 1.76862980769231 0.0195400852555542 0.130828889642042 GO:0016791 phosphatase activity 42/2080 273/18639 0.153846153846154 1.37862426035503 0.0195516694978959 0.130828889642042 GO:0033130 acetylcholine receptor binding 5/2080 15/18639 0.333333333333333 2.98701923076923 0.019816102177052 0.130828889642042 GO:0048531 beta-1,3-galactosyltransferase activity 5/2080 15/18639 0.333333333333333 2.98701923076923 0.019816102177052 0.130828889642042 GO:0061578 K63-linked deubiquitinase activity 5/2080 15/18639 0.333333333333333 2.98701923076923 0.019816102177052 0.130828889642042 GO:0030507 spectrin binding 7/2080 26/18639 0.269230769230769 2.4125924556213 0.0207671680819839 0.135649374492958 GO:0034237 protein kinase A regulatory subunit binding 7/2080 26/18639 0.269230769230769 2.4125924556213 0.0207671680819839 0.135649374492958 GO:0043425 bHLH transcription factor binding 8/2080 32/18639 0.25 2.24026442307692 0.0215206996735574 0.139778839013314 GO:0016504 peptidase activator activity 12/2080 57/18639 0.210526315789474 1.88653846153846 0.0216270190655779 0.139778839013314 GO:0005010 insulin-like growth factor receptor activity 11/2080 51/18639 0.215686274509804 1.93277714932127 0.0229937382592841 0.147064117616671 GO:0030544 Hsp70 protein binding 11/2080 51/18639 0.215686274509804 1.93277714932127 0.0229937382592841 0.147064117616671 GO:0072542 protein phosphatase activator activity 6/2080 21/18639 0.285714285714286 2.5603021978022 0.0237484451404822 0.151104096541514 GO:0019199 transmembrane receptor protein kinase activity 15/2080 78/18639 0.192307692307692 1.72328032544379 0.0243446006676529 0.154098812473597 GO:0061980 regulatory RNA binding 12/2080 58/18639 0.206896551724138 1.85401193633952 0.0245878593120619 0.154840467872882 GO:0001671 ATPase activator activity 7/2080 27/18639 0.259259259259259 2.32323717948718 0.0254089513616981 0.157586829657401 GO:0005104 fibroblast growth factor receptor binding 7/2080 27/18639 0.259259259259259 2.32323717948718 0.0254089513616981 0.157586829657401 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 7/2080 27/18639 0.259259259259259 2.32323717948718 0.0254089513616981 0.157586829657401 GO:0005521 lamin binding 5/2080 16/18639 0.3125 2.80033052884615 0.0262330323905677 0.158902659654676 GO:0008142 oxysterol binding 5/2080 16/18639 0.3125 2.80033052884615 0.0262330323905677 0.158902659654676 GO:0070411 I-SMAD binding 5/2080 16/18639 0.3125 2.80033052884615 0.0262330323905677 0.158902659654676 GO:0140327 flippase activity 5/2080 16/18639 0.3125 2.80033052884615 0.0262330323905677 0.158902659654676 GO:0005080 protein kinase C binding 11/2080 52/18639 0.211538461538462 1.89560835798817 0.0263162789332227 0.158902659654676 GO:0002162 dystroglycan binding 4/2080 11/18639 0.363636363636364 3.25856643356643 0.0267857089157312 0.158902659654676 GO:0010854 adenylate cyclase regulator activity 4/2080 11/18639 0.363636363636364 3.25856643356643 0.0267857089157312 0.158902659654676 GO:0034056 estrogen response element binding 4/2080 11/18639 0.363636363636364 3.25856643356643 0.0267857089157312 0.158902659654676 GO:0097493 structural molecule activity conferring elasticity 4/2080 11/18639 0.363636363636364 3.25856643356643 0.0267857089157312 0.158902659654676 GO:0019838 growth factor binding 23/2080 136/18639 0.169117647058824 1.51547299208145 0.027600034357496 0.162946356687525 GO:0001786 phosphatidylserine binding 12/2080 59/18639 0.203389830508475 1.82258800521512 0.0278350067521156 0.16354731239999 GO:0019903 protein phosphatase binding 24/2080 144/18639 0.166666666666667 1.49350961538462 0.0290669967539329 0.168388987239025 GO:0035401 histone H3Y41 kinase activity 20/2080 115/18639 0.173913043478261 1.55844481605351 0.0292075360601893 0.168388987239025 GO:0101005 deubiquitinase activity 20/2080 115/18639 0.173913043478261 1.55844481605351 0.0292075360601893 0.168388987239025 GO:0140801 histone H2AXY142 kinase activity 20/2080 115/18639 0.173913043478261 1.55844481605351 0.0292075360601893 0.168388987239025 GO:0004843 cysteine-type deubiquitinase activity 19/2080 108/18639 0.175925925925926 1.57648237179487 0.029611795281523 0.169373561598552 GO:0050321 tau-protein kinase activity 6/2080 22/18639 0.272727272727273 2.44392482517482 0.029654165915056 0.169373561598552 GO:0140296 general transcription initiation factor binding 11/2080 53/18639 0.207547169811321 1.85984216255443 0.0299719955455889 0.170396345046218 GO:0036408 histone H3K14 acetyltransferase activity 7/2080 28/18639 0.25 2.24026442307692 0.0307122432699044 0.172212943997455 GO:0046875 ephrin receptor binding 7/2080 28/18639 0.25 2.24026442307692 0.0307122432699044 0.172212943997455 GO:0051019 mitogen-activated protein kinase binding 7/2080 28/18639 0.25 2.24026442307692 0.0307122432699044 0.172212943997455 GO:0004714 transmembrane receptor protein tyrosine kinase activity 12/2080 60/18639 0.2 1.79221153846154 0.0313820522011645 0.175168909559228 GO:0042054 histone methyltransferase activity 13/2080 67/18639 0.194029850746269 1.73871268656716 0.0323168195540862 0.179570381956642 GO:0008276 protein methyltransferase activity 17/2080 95/18639 0.178947368421053 1.60355769230769 0.0329903479273312 0.182487149796228 GO:0004197 cysteine-type endopeptidase activity 16/2080 88/18639 0.181818181818182 1.62928321678322 0.0331560557000523 0.182581329146476 GO:0031489 myosin V binding 5/2080 17/18639 0.294117647058824 2.63560520361991 0.0338356285475248 0.183801210060822 GO:0032183 SUMO binding 5/2080 17/18639 0.294117647058824 2.63560520361991 0.0338356285475248 0.183801210060822 GO:0005178 integrin binding 26/2080 161/18639 0.161490683229814 1.44712732919255 0.033938172656936 0.183801210060822 GO:0003925 G protein activity 11/2080 54/18639 0.203703703703704 1.82540064102564 0.0339762823158035 0.183801210060822 GO:0042578 phosphoric ester hydrolase activity 52/2080 363/18639 0.143250688705234 1.28367768595041 0.0354693369239634 0.189411639224223 GO:0004722 protein serine/threonine phosphatase activity 18/2080 103/18639 0.174757281553398 1.56601008215086 0.0356160929568833 0.189411639224223 GO:1990841 promoter-specific chromatin binding 13/2080 68/18639 0.191176470588235 1.71314338235294 0.0360212942856508 0.189411639224223 GO:0005158 insulin receptor binding 6/2080 23/18639 0.260869565217391 2.33766722408027 0.0364454397129543 0.189411639224223 GO:0044013 histone H2B acetyltransferase activity 6/2080 23/18639 0.260869565217391 2.33766722408027 0.0364454397129543 0.189411639224223 GO:0070577 lysine-acetylated histone binding 6/2080 23/18639 0.260869565217391 2.33766722408027 0.0364454397129543 0.189411639224223 GO:0005078 MAP-kinase scaffold activity 4/2080 12/18639 0.333333333333333 2.98701923076923 0.0367051916238988 0.189411639224223 GO:0005165 neurotrophin receptor binding 4/2080 12/18639 0.333333333333333 2.98701923076923 0.0367051916238988 0.189411639224223 GO:0045295 gamma-catenin binding 4/2080 12/18639 0.333333333333333 2.98701923076923 0.0367051916238988 0.189411639224223 GO:0070410 co-SMAD binding 4/2080 12/18639 0.333333333333333 2.98701923076923 0.0367051916238988 0.189411639224223 GO:0051861 glycolipid binding 7/2080 29/18639 0.241379310344828 2.16301392572944 0.0367100734001344 0.189411639224223 GO:0004402 histone acetyltransferase activity 9/2080 42/18639 0.214285714285714 1.92022664835165 0.0392197055633667 0.199841487268939 GO:0043175 RNA polymerase core enzyme binding 9/2080 42/18639 0.214285714285714 1.92022664835165 0.0392197055633667 0.199841487268939 GO:0051879 Hsp90 protein binding 9/2080 42/18639 0.214285714285714 1.92022664835165 0.0392197055633667 0.199841487268939 GO:0016279 protein-lysine N-methyltransferase activity 13/2080 69/18639 0.188405797101449 1.6883152173913 0.0400189137171978 0.203071182002971 GO:0017022 myosin binding 14/2080 76/18639 0.184210526315789 1.65072115384615 0.0402320047604213 0.203312353274886 GO:0005200 structural constituent of cytoskeleton 19/2080 112/18639 0.169642857142857 1.52017942994505 0.0411849301017484 0.207274976085848 GO:0000993 RNA polymerase II complex binding 8/2080 36/18639 0.222222222222222 1.99134615384615 0.0415934265768469 0.208476440148441 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 5/2080 18/18639 0.277777777777778 2.48918269230769 0.0426696903947851 0.212139189493102 GO:0070064 proline-rich region binding 5/2080 18/18639 0.277777777777778 2.48918269230769 0.0426696903947851 0.212139189493102 GO:0004725 protein tyrosine phosphatase activity 17/2080 98/18639 0.173469387755102 1.55446919152276 0.0428629115012241 0.212240545659287 GO:0043995 histone H4K5 acetyltransferase activity 7/2080 30/18639 0.233333333333333 2.09091346153846 0.0434301570135372 0.212479015189736 GO:0043996 histone H4K8 acetyltransferase activity 7/2080 30/18639 0.233333333333333 2.09091346153846 0.0434301570135372 0.212479015189736 GO:0043997 histone H4K12 acetyltransferase activity 7/2080 30/18639 0.233333333333333 2.09091346153846 0.0434301570135372 0.212479015189736 GO:0070300 phosphatidic acid binding 6/2080 24/18639 0.25 2.24026442307692 0.0441563955716875 0.214269031491979 GO:0070840 dynein complex binding 6/2080 24/18639 0.25 2.24026442307692 0.0441563955716875 0.214269031491979 GO:0016278 lysine N-methyltransferase activity 13/2080 70/18639 0.185714285714286 1.66419642857143 0.0443194902271683 0.214269031491979 GO:0004712 protein serine/threonine/tyrosine kinase activity 9/2080 43/18639 0.209302325581395 1.87557021466905 0.0448737148185091 0.216097732537762 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 21/2080 128/18639 0.1640625 1.47017352764423 0.0454285253577494 0.217914957575454 GO:0005525 GTP binding 53/2080 378/18639 0.14021164021164 1.2564445970696 0.0476126486235419 0.227503239337391 GO:1901681 sulfur compound binding 40/2080 275/18639 0.145454545454545 1.30342657342657 0.048392964518571 0.228866698775671 GO:0140333 glycerophospholipid flippase activity 4/2080 13/18639 0.307692307692308 2.75724852071006 0.0484571186332854 0.228866698775671 GO:0140852 histone ubiquitin ligase activity 4/2080 13/18639 0.307692307692308 2.75724852071006 0.0484571186332854 0.228866698775671 GO:0019955 cytokine binding 23/2080 144/18639 0.159722222222222 1.43128004807692 0.0489279130264958 0.230204893473321 GO:0019888 protein phosphatase regulator activity 18/2080 107/18639 0.168224299065421 1.50746764917326 0.0493283989906497 0.231203335727167 GO:0070273 phosphatidylinositol-4-phosphate binding 7/2080 31/18639 0.225806451612903 2.02346464019851 0.0508945091167687 0.237636719374114 GO:0042800 histone H3K4 methyltransferase activity 5/2080 19/18639 0.263157894736842 2.35817307692308 0.052762101312742 0.243888142405825 GO:0046624 sphingolipid transporter activity 5/2080 19/18639 0.263157894736842 2.35817307692308 0.052762101312742 0.243888142405825 GO:0005030 neurotrophin receptor activity 10/2080 51/18639 0.196078431372549 1.75707013574661 0.0528291904559849 0.243888142405825 GO:0005496 steroid binding 18/2080 108/18639 0.166666666666667 1.49350961538462 0.053271719732475 0.245010006859473 GO:0005109 frizzled binding 8/2080 38/18639 0.210526315789474 1.88653846153846 0.0551711831419435 0.251859527502998 GO:0042162 telomeric DNA binding 8/2080 38/18639 0.210526315789474 1.88653846153846 0.0551711831419435 0.251859527502998 GO:0140303 intramembrane lipid transporter activity 9/2080 45/18639 0.2 1.79221153846154 0.057750683805504 0.262658665604292 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 7/2080 32/18639 0.21875 1.96023137019231 0.0591191757608679 0.266933440809995 GO:0043539 protein serine/threonine kinase activator activity 13/2080 73/18639 0.178082191780822 1.59580479452055 0.0591253223943962 0.266933440809995 GO:1990782 protein tyrosine kinase binding 19/2080 117/18639 0.162393162393162 1.45521449704142 0.05987026578066 0.26930654351154 GO:0004705 JUN kinase activity 4/2080 14/18639 0.285714285714286 2.5603021978022 0.0620318372850061 0.271834779592786 GO:0005161 platelet-derived growth factor receptor binding 4/2080 14/18639 0.285714285714286 2.5603021978022 0.0620318372850061 0.271834779592786 GO:0008559 ABC-type xenobiotic transporter activity 4/2080 14/18639 0.285714285714286 2.5603021978022 0.0620318372850061 0.271834779592786 GO:0061665 SUMO ligase activity 4/2080 14/18639 0.285714285714286 2.5603021978022 0.0620318372850061 0.271834779592786 GO:0070742 C2H2 zinc finger domain binding 4/2080 14/18639 0.285714285714286 2.5603021978022 0.0620318372850061 0.271834779592786 GO:0071933 Arp2/3 complex binding 4/2080 14/18639 0.285714285714286 2.5603021978022 0.0620318372850061 0.271834779592786 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 6/2080 26/18639 0.230769230769231 2.06793639053254 0.0624245992224476 0.271834779592786 GO:0043548 phosphatidylinositol 3-kinase binding 6/2080 26/18639 0.230769230769231 2.06793639053254 0.0624245992224476 0.271834779592786 GO:0052742 phosphatidylinositol kinase activity 6/2080 26/18639 0.230769230769231 2.06793639053254 0.0624245992224476 0.271834779592786 GO:0008094 ATP-dependent activity, acting on DNA 31/2080 210/18639 0.147619047619048 1.3228228021978 0.0638048857047484 0.276283681752969 GO:0030742 GTP-dependent protein binding 5/2080 20/18639 0.25 2.24026442307692 0.0641212127846874 0.276283681752969 GO:0061608 nuclear import signal receptor activity 5/2080 20/18639 0.25 2.24026442307692 0.0641212127846874 0.276283681752969 GO:0005003 ephrin receptor activity 10/2080 53/18639 0.188679245283019 1.69076560232221 0.0659254612031778 0.279656044206019 GO:0005005 transmembrane-ephrin receptor activity 10/2080 53/18639 0.188679245283019 1.69076560232221 0.0659254612031778 0.279656044206019 GO:0051018 protein kinase A binding 10/2080 53/18639 0.188679245283019 1.69076560232221 0.0659254612031778 0.279656044206019 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 11/2080 60/18639 0.183333333333333 1.64286057692308 0.0660425511561445 0.279656044206019 GO:0098531 ligand-modulated transcription factor activity 11/2080 60/18639 0.183333333333333 1.64286057692308 0.0660425511561445 0.279656044206019 GO:1902936 phosphatidylinositol bisphosphate binding 18/2080 111/18639 0.162162162162162 1.45314449064449 0.0664138834048355 0.280262023440337 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 15/2080 89/18639 0.168539325842697 1.51029062229905 0.0674329538748875 0.282620025113863 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 15/2080 89/18639 0.168539325842697 1.51029062229905 0.0674329538748875 0.282620025113863 GO:0140311 protein sequestering activity 7/2080 33/18639 0.212121212121212 1.90083041958042 0.068114079302945 0.284503705387811 GO:0044183 protein folding chaperone 13/2080 75/18639 0.173333333333333 1.55325 0.07065344152999 0.29410991931806 GO:0140658 ATP-dependent chromatin remodeler activity 24/2080 158/18639 0.151898734177215 1.36117332035054 0.0726151497625435 0.298582032351785 GO:0061733 protein-lysine-acetyltransferase activity 9/2080 47/18639 0.191489361702128 1.71594721767594 0.0727903267565981 0.298582032351785 GO:0140938 histone H3 methyltransferase activity 9/2080 47/18639 0.191489361702128 1.71594721767594 0.0727903267565981 0.298582032351785 GO:0140793 histone H2AXY142 phosphatase activity 15/2080 90/18639 0.166666666666667 1.49350961538462 0.0729505470802957 0.298582032351785 GO:0023026 MHC class II protein complex binding 6/2080 27/18639 0.222222222222222 1.99134615384615 0.073000498611233 0.298582032351785 GO:0015485 cholesterol binding 10/2080 54/18639 0.185185185185185 1.65945512820513 0.0731866382230354 0.298582032351785 GO:0032182 ubiquitin-like protein binding 19/2080 120/18639 0.158333333333333 1.41883413461538 0.073544617351456 0.299048973866185 GO:0005123 death receptor binding 5/2080 21/18639 0.238095238095238 2.13358516483516 0.0767377026735014 0.307528611031519 GO:0015174 basic amino acid transmembrane transporter activity 5/2080 21/18639 0.238095238095238 2.13358516483516 0.0767377026735014 0.307528611031519 GO:0035613 RNA stem-loop binding 5/2080 21/18639 0.238095238095238 2.13358516483516 0.0767377026735014 0.307528611031519 GO:0036122 BMP binding 5/2080 21/18639 0.238095238095238 2.13358516483516 0.0767377026735014 0.307528611031519 GO:0005041 low-density lipoprotein particle receptor activity 4/2080 15/18639 0.266666666666667 2.38961538461538 0.0773830136878984 0.307528611031519 GO:0141050 histone H3K deacetylase activity 4/2080 15/18639 0.266666666666667 2.38961538461538 0.0773830136878984 0.307528611031519 GO:0141051 histone H4K deacetylase activity 4/2080 15/18639 0.266666666666667 2.38961538461538 0.0773830136878984 0.307528611031519 GO:0008376 acetylgalactosaminyltransferase activity 7/2080 34/18639 0.205882352941176 1.84492364253394 0.0778829719114989 0.308517062926841 GO:0051082 unfolded protein binding 19/2080 121/18639 0.15702479338843 1.40710823267641 0.0785336596938819 0.310094321878093 GO:0015179 L-amino acid transmembrane transporter activity 11/2080 62/18639 0.17741935483871 1.58986507444169 0.0800208644238325 0.313044654142923 GO:0019001 guanyl nucleotide binding 54/2080 400/18639 0.135 1.20974278846154 0.0800561731606811 0.313044654142923 GO:0032561 guanyl ribonucleotide binding 54/2080 400/18639 0.135 1.20974278846154 0.0800561731606811 0.313044654142923 GO:0001727 lipid kinase activity 8/2080 41/18639 0.195121951219512 1.7484990619137 0.080300542390082 0.313044654142923 GO:0019789 SUMO transferase activity 6/2080 28/18639 0.214285714285714 1.92022664835165 0.0845336591588681 0.313817333517279 GO:0141052 histone H3 demethylase activity 6/2080 28/18639 0.214285714285714 1.92022664835165 0.0845336591588681 0.313817333517279 GO:0016229 steroid dehydrogenase activity 7/2080 35/18639 0.2 1.79221153846154 0.0884234896458958 0.313817333517279 GO:0043015 gamma-tubulin binding 7/2080 35/18639 0.2 1.79221153846154 0.0884234896458958 0.313817333517279 GO:0019894 kinesin binding 8/2080 42/18639 0.19047619047619 1.70686813186813 0.0899666216434269 0.313817333517279 GO:0042056 chemoattractant activity 8/2080 42/18639 0.19047619047619 1.70686813186813 0.0899666216434269 0.313817333517279 GO:0005004 GPI-linked ephrin receptor activity 9/2080 49/18639 0.183673469387755 1.64590855572998 0.0900369407732416 0.313817333517279 GO:0005008 hepatocyte growth factor receptor activity 9/2080 49/18639 0.183673469387755 1.64590855572998 0.0900369407732416 0.313817333517279 GO:0005009 insulin receptor activity 9/2080 49/18639 0.183673469387755 1.64590855572998 0.0900369407732416 0.313817333517279 GO:0005011 macrophage colony-stimulating factor receptor activity 9/2080 49/18639 0.183673469387755 1.64590855572998 0.0900369407732416 0.313817333517279 GO:0005018 platelet-derived growth factor alpha-receptor activity 9/2080 49/18639 0.183673469387755 1.64590855572998 0.0900369407732416 0.313817333517279 GO:0005020 stem cell factor receptor activity 9/2080 49/18639 0.183673469387755 1.64590855572998 0.0900369407732416 0.313817333517279 GO:0008288 boss receptor activity 9/2080 49/18639 0.183673469387755 1.64590855572998 0.0900369407732416 0.313817333517279 GO:0035254 glutamate receptor binding 9/2080 49/18639 0.183673469387755 1.64590855572998 0.0900369407732416 0.313817333517279 GO:0036332 placental growth factor receptor activity 9/2080 49/18639 0.183673469387755 1.64590855572998 0.0900369407732416 0.313817333517279 GO:0038062 protein tyrosine kinase collagen receptor activity 9/2080 49/18639 0.183673469387755 1.64590855572998 0.0900369407732416 0.313817333517279 GO:0060175 brain-derived neurotrophic factor receptor activity 9/2080 49/18639 0.183673469387755 1.64590855572998 0.0900369407732416 0.313817333517279 GO:0004407 histone deacetylase activity 5/2080 22/18639 0.227272727272727 2.03660402097902 0.0905858017201031 0.313817333517279 GO:0032931 histone H3K56 acetyltransferase activity 5/2080 22/18639 0.227272727272727 2.03660402097902 0.0905858017201031 0.313817333517279 GO:0033558 protein lysine deacetylase activity 5/2080 22/18639 0.227272727272727 2.03660402097902 0.0905858017201031 0.313817333517279 GO:0043992 histone H3K9 acetyltransferase activity 5/2080 22/18639 0.227272727272727 2.03660402097902 0.0905858017201031 0.313817333517279 GO:0043993 histone H3K18 acetyltransferase activity 5/2080 22/18639 0.227272727272727 2.03660402097902 0.0905858017201031 0.313817333517279 GO:0043994 histone H3K23 acetyltransferase activity 5/2080 22/18639 0.227272727272727 2.03660402097902 0.0905858017201031 0.313817333517279 GO:0043999 histone H2AK5 acetyltransferase activity 5/2080 22/18639 0.227272727272727 2.03660402097902 0.0905858017201031 0.313817333517279 GO:0044012 histone H2AK9 acetyltransferase activity 5/2080 22/18639 0.227272727272727 2.03660402097902 0.0905858017201031 0.313817333517279 GO:0044014 histone H2BK5 acetyltransferase activity 5/2080 22/18639 0.227272727272727 2.03660402097902 0.0905858017201031 0.313817333517279 GO:0044015 histone H2BK12 acetyltransferase activity 5/2080 22/18639 0.227272727272727 2.03660402097902 0.0905858017201031 0.313817333517279 GO:0044016 histone H3K4 acetyltransferase activity 5/2080 22/18639 0.227272727272727 2.03660402097902 0.0905858017201031 0.313817333517279 GO:0044017 histone H3K27 acetyltransferase activity 5/2080 22/18639 0.227272727272727 2.03660402097902 0.0905858017201031 0.313817333517279 GO:0044018 histone H3K36 acetyltransferase activity 5/2080 22/18639 0.227272727272727 2.03660402097902 0.0905858017201031 0.313817333517279 GO:0046972 histone H4K16 acetyltransferase activity 5/2080 22/18639 0.227272727272727 2.03660402097902 0.0905858017201031 0.313817333517279 GO:0070034 telomerase RNA binding 5/2080 22/18639 0.227272727272727 2.03660402097902 0.0905858017201031 0.313817333517279 GO:0140908 histone H3K122 acetyltransferase activity 5/2080 22/18639 0.227272727272727 2.03660402097902 0.0905858017201031 0.313817333517279 GO:0004955 prostaglandin receptor activity 3/2080 10/18639 0.3 2.68831730769231 0.0914874636801189 0.313817333517279 GO:0015658 branched-chain amino acid transmembrane transporter activity 3/2080 10/18639 0.3 2.68831730769231 0.0914874636801189 0.313817333517279 GO:0016303 1-phosphatidylinositol-3-kinase activity 3/2080 10/18639 0.3 2.68831730769231 0.0914874636801189 0.313817333517279 GO:0019911 structural constituent of myelin sheath 3/2080 10/18639 0.3 2.68831730769231 0.0914874636801189 0.313817333517279 GO:0032395 MHC class II receptor activity 3/2080 10/18639 0.3 2.68831730769231 0.0914874636801189 0.313817333517279 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 3/2080 10/18639 0.3 2.68831730769231 0.0914874636801189 0.313817333517279 GO:0035256 G protein-coupled glutamate receptor binding 3/2080 10/18639 0.3 2.68831730769231 0.0914874636801189 0.313817333517279 GO:0043208 glycosphingolipid binding 3/2080 10/18639 0.3 2.68831730769231 0.0914874636801189 0.313817333517279 GO:0051880 G-quadruplex DNA binding 3/2080 10/18639 0.3 2.68831730769231 0.0914874636801189 0.313817333517279 GO:0140999 histone H3K4 trimethyltransferase activity 3/2080 10/18639 0.3 2.68831730769231 0.0914874636801189 0.313817333517279 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 4/2080 16/18639 0.25 2.24026442307692 0.0944330074536753 0.320341804290368 GO:0004707 MAP kinase activity 4/2080 16/18639 0.25 2.24026442307692 0.0944330074536753 0.320341804290368 GO:0022858 alanine transmembrane transporter activity 4/2080 16/18639 0.25 2.24026442307692 0.0944330074536753 0.320341804290368 GO:0034450 ubiquitin-ubiquitin ligase activity 4/2080 16/18639 0.25 2.24026442307692 0.0944330074536753 0.320341804290368 GO:0005006 epidermal growth factor receptor activity 9/2080 50/18639 0.18 1.61299038461538 0.099488661525668 0.3338034873047 GO:0005007 fibroblast growth factor receptor activity 9/2080 50/18639 0.18 1.61299038461538 0.099488661525668 0.3338034873047 GO:0005017 platelet-derived growth factor receptor activity 9/2080 50/18639 0.18 1.61299038461538 0.099488661525668 0.3338034873047 GO:0005019 platelet-derived growth factor beta-receptor activity 9/2080 50/18639 0.18 1.61299038461538 0.099488661525668 0.3338034873047 GO:0004222 metalloendopeptidase activity 17/2080 110/18639 0.154545454545455 1.38489073426573 0.103157176179692 0.345168970977281 GO:0005021 vascular endothelial growth factor receptor activity 9/2080 51/18639 0.176470588235294 1.58136312217195 0.109487119612029 0.36445251551767 GO:0001965 G-protein alpha-subunit binding 6/2080 30/18639 0.2 1.79221153846154 0.110404182225223 0.36445251551767 GO:0032452 histone demethylase activity 6/2080 30/18639 0.2 1.79221153846154 0.110404182225223 0.36445251551767 GO:0051721 protein phosphatase 2A binding 6/2080 30/18639 0.2 1.79221153846154 0.110404182225223 0.36445251551767 GO:0070566 adenylyltransferase activity 6/2080 30/18639 0.2 1.79221153846154 0.110404182225223 0.36445251551767 GO:0043014 alpha-tubulin binding 8/2080 44/18639 0.181818181818182 1.62928321678322 0.111212928343111 0.366138005376248 GO:0043394 proteoglycan binding 7/2080 37/18639 0.189189189189189 1.69533523908524 0.11178031855962 0.366344751206667 GO:0004029 aldehyde dehydrogenase (NAD+) activity 4/2080 17/18639 0.235294117647059 2.10848416289593 0.113078354809414 0.366344751206667 GO:0030548 acetylcholine receptor regulator activity 4/2080 17/18639 0.235294117647059 2.10848416289593 0.113078354809414 0.366344751206667 GO:0070403 NAD+ binding 4/2080 17/18639 0.235294117647059 2.10848416289593 0.113078354809414 0.366344751206667 GO:0000099 sulfur amino acid transmembrane transporter activity 3/2080 11/18639 0.272727272727273 2.44392482517482 0.115750621716764 0.366344751206667 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 3/2080 11/18639 0.272727272727273 2.44392482517482 0.115750621716764 0.366344751206667 GO:0004954 prostanoid receptor activity 3/2080 11/18639 0.272727272727273 2.44392482517482 0.115750621716764 0.366344751206667 GO:0005114 type II transforming growth factor beta receptor binding 3/2080 11/18639 0.272727272727273 2.44392482517482 0.115750621716764 0.366344751206667 GO:0005225 volume-sensitive anion channel activity 3/2080 11/18639 0.272727272727273 2.44392482517482 0.115750621716764 0.366344751206667 GO:0008046 axon guidance receptor activity 3/2080 11/18639 0.272727272727273 2.44392482517482 0.115750621716764 0.366344751206667 GO:0019215 intermediate filament binding 3/2080 11/18639 0.272727272727273 2.44392482517482 0.115750621716764 0.366344751206667 GO:0034713 type I transforming growth factor beta receptor binding 3/2080 11/18639 0.272727272727273 2.44392482517482 0.115750621716764 0.366344751206667 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 3/2080 11/18639 0.272727272727273 2.44392482517482 0.115750621716764 0.366344751206667 GO:0140031 phosphorylation-dependent protein binding 3/2080 11/18639 0.272727272727273 2.44392482517482 0.115750621716764 0.366344751206667 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 3/2080 11/18639 0.272727272727273 2.44392482517482 0.115750621716764 0.366344751206667 GO:0004879 nuclear receptor activity 10/2080 59/18639 0.169491525423729 1.51882333767927 0.116724461101506 0.367532405724742 GO:0070888 E-box binding 10/2080 59/18639 0.169491525423729 1.51882333767927 0.116724461101506 0.367532405724742 GO:0005516 calmodulin binding 29/2080 207/18639 0.140096618357488 1.25541387959866 0.117243989300395 0.368224089158274 GO:0003678 DNA helicase activity 12/2080 74/18639 0.162162162162162 1.45314449064449 0.11798849103659 0.369617007635031 GO:0043998 histone H2A acetyltransferase activity 5/2080 24/18639 0.208333333333333 1.86688701923077 0.121800684744124 0.380588399149579 GO:0004715 non-membrane spanning protein tyrosine kinase activity 8/2080 45/18639 0.177777777777778 1.59307692307692 0.122772332567459 0.38265082333208 GO:0017147 Wnt-protein binding 6/2080 31/18639 0.193548387096774 1.7343982630273 0.124686503771251 0.386654107654285 GO:0140457 protein demethylase activity 6/2080 31/18639 0.193548387096774 1.7343982630273 0.124686503771251 0.386654107654285 GO:0061775 cohesin loader activity 22/2080 153/18639 0.143790849673203 1.28851809954751 0.128407197149923 0.397189012846613 GO:0034212 protein N-acetyltransferase activity 9/2080 53/18639 0.169811320754717 1.52168904208999 0.131090229957922 0.403455645083531 GO:0038064 collagen receptor activity 9/2080 53/18639 0.169811320754717 1.52168904208999 0.131090229957922 0.403455645083531 GO:0061134 peptidase regulator activity 31/2080 226/18639 0.13716814159292 1.22917163036079 0.131996002460128 0.403860746999665 GO:0008525 phosphatidylcholine transporter activity 4/2080 18/18639 0.222222222222222 1.99134615384615 0.133195116070737 0.403860746999665 GO:0015172 acidic amino acid transmembrane transporter activity 4/2080 18/18639 0.222222222222222 1.99134615384615 0.133195116070737 0.403860746999665 GO:0030228 lipoprotein particle receptor activity 4/2080 18/18639 0.222222222222222 1.99134615384615 0.133195116070737 0.403860746999665 GO:0050811 GABA receptor binding 4/2080 18/18639 0.222222222222222 1.99134615384615 0.133195116070737 0.403860746999665 GO:0099602 neurotransmitter receptor regulator activity 4/2080 18/18639 0.222222222222222 1.99134615384615 0.133195116070737 0.403860746999665 GO:0005319 lipid transporter activity 25/2080 178/18639 0.140449438202247 1.25857551858254 0.13477887079295 0.407656288999366 GO:0000030 mannosyltransferase activity 5/2080 25/18639 0.2 1.79221153846154 0.13904801945957 0.416465775356957 GO:0004709 MAP kinase kinase kinase activity 5/2080 25/18639 0.2 1.79221153846154 0.13904801945957 0.416465775356957 GO:0017025 TBP-class protein binding 5/2080 25/18639 0.2 1.79221153846154 0.13904801945957 0.416465775356957 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 5/2080 25/18639 0.2 1.79221153846154 0.13904801945957 0.416465775356957 GO:0008378 galactosyltransferase activity 6/2080 32/18639 0.1875 1.68019831730769 0.139817425619802 0.416737375391059 GO:0051059 NF-kappaB binding 6/2080 32/18639 0.1875 1.68019831730769 0.139817425619802 0.416737375391059 GO:0004859 phospholipase inhibitor activity 3/2080 12/18639 0.25 2.24026442307692 0.142099098414386 0.417235325041639 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 3/2080 12/18639 0.25 2.24026442307692 0.142099098414386 0.417235325041639 GO:0031543 peptidyl-proline dioxygenase activity 3/2080 12/18639 0.25 2.24026442307692 0.142099098414386 0.417235325041639 GO:0034452 dynactin binding 3/2080 12/18639 0.25 2.24026442307692 0.142099098414386 0.417235325041639 GO:0035014 phosphatidylinositol 3-kinase regulator activity 3/2080 12/18639 0.25 2.24026442307692 0.142099098414386 0.417235325041639 GO:0141221 histone deacetylase activity, hydrolytic mechanism 3/2080 12/18639 0.25 2.24026442307692 0.142099098414386 0.417235325041639 GO:0008080 N-acetyltransferase activity 11/2080 69/18639 0.159420289855072 1.42857441471572 0.142362867420559 0.417235325041639 GO:0140359 ABC-type transporter activity 8/2080 47/18639 0.170212765957447 1.52528641571195 0.147683480115819 0.431798365671966 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 7/2080 40/18639 0.175 1.56818509615385 0.152214361486078 0.44398868385963 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 4/2080 19/18639 0.210526315789474 1.88653846153846 0.154643920006202 0.445781065182197 GO:0005520 insulin-like growth factor binding 4/2080 19/18639 0.210526315789474 1.88653846153846 0.154643920006202 0.445781065182197 GO:0031420 alkali metal ion binding 4/2080 19/18639 0.210526315789474 1.88653846153846 0.154643920006202 0.445781065182197 GO:0042577 lipid phosphatase activity 4/2080 19/18639 0.210526315789474 1.88653846153846 0.154643920006202 0.445781065182197 GO:0140036 ubiquitin-modified protein reader activity 4/2080 19/18639 0.210526315789474 1.88653846153846 0.154643920006202 0.445781065182197 GO:0008157 protein phosphatase 1 binding 5/2080 26/18639 0.192307692307692 1.72328032544379 0.157291690944599 0.450242882237688 GO:0050681 nuclear androgen receptor binding 5/2080 26/18639 0.192307692307692 1.72328032544379 0.157291690944599 0.450242882237688 GO:0050750 low-density lipoprotein particle receptor binding 5/2080 26/18639 0.192307692307692 1.72328032544379 0.157291690944599 0.450242882237688 GO:0016410 N-acyltransferase activity 14/2080 94/18639 0.148936170212766 1.33462561374795 0.160609408722918 0.458670590492426 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 7/2080 41/18639 0.170731707317073 1.52993667917448 0.167020147770548 0.469797965519542 GO:0015175 neutral L-amino acid transmembrane transporter activity 7/2080 41/18639 0.170731707317073 1.52993667917448 0.167020147770548 0.469797965519542 GO:0017080 sodium channel regulator activity 7/2080 41/18639 0.170731707317073 1.52993667917448 0.167020147770548 0.469797965519542 GO:0005172 vascular endothelial growth factor receptor binding 3/2080 13/18639 0.230769230769231 2.06793639053254 0.170191692348717 0.469797965519542 GO:0031994 insulin-like growth factor I binding 3/2080 13/18639 0.230769230769231 2.06793639053254 0.170191692348717 0.469797965519542 GO:0046974 histone H3K9 methyltransferase activity 3/2080 13/18639 0.230769230769231 2.06793639053254 0.170191692348717 0.469797965519542 GO:0046975 histone H3K36 methyltransferase activity 3/2080 13/18639 0.230769230769231 2.06793639053254 0.170191692348717 0.469797965519542 GO:0051011 microtubule minus-end binding 3/2080 13/18639 0.230769230769231 2.06793639053254 0.170191692348717 0.469797965519542 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 3/2080 13/18639 0.230769230769231 2.06793639053254 0.170191692348717 0.469797965519542 GO:0097157 pre-mRNA intronic binding 3/2080 13/18639 0.230769230769231 2.06793639053254 0.170191692348717 0.469797965519542 GO:0140666 annealing activity 3/2080 13/18639 0.230769230769231 2.06793639053254 0.170191692348717 0.469797965519542 GO:0004867 serine-type endopeptidase inhibitor activity 14/2080 95/18639 0.147368421052632 1.32057692307692 0.170235299995323 0.469797965519542 GO:0000510 H3-H4 histone complex chaperone activity 21/2080 151/18639 0.139072847682119 1.24623981151299 0.170626948389019 0.469797965519542 GO:0140584 chromatin extrusion motor activity 21/2080 151/18639 0.139072847682119 1.24623981151299 0.170626948389019 0.469797965519542 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 21/2080 151/18639 0.139072847682119 1.24623981151299 0.170626948389019 0.469797965519542 GO:0140849 ATP-dependent H2AZ histone chaperone activity 21/2080 151/18639 0.139072847682119 1.24623981151299 0.170626948389019 0.469797965519542 GO:0005126 cytokine receptor binding 36/2080 275/18639 0.130909090909091 1.17308391608392 0.175578430426307 0.480168145971487 GO:0035255 ionotropic glutamate receptor binding 5/2080 27/18639 0.185185185185185 1.65945512820513 0.176448780111274 0.480168145971487 GO:0010851 cyclase regulator activity 4/2080 20/18639 0.2 1.79221153846154 0.17727459681158 0.480168145971487 GO:0015095 magnesium ion transmembrane transporter activity 4/2080 20/18639 0.2 1.79221153846154 0.17727459681158 0.480168145971487 GO:0016505 peptidase activator activity involved in apoptotic process 4/2080 20/18639 0.2 1.79221153846154 0.17727459681158 0.480168145971487 GO:0140939 histone H4 methyltransferase activity 4/2080 20/18639 0.2 1.79221153846154 0.17727459681158 0.480168145971487 GO:0003689 DNA clamp loader activity 22/2080 160/18639 0.1375 1.23214543269231 0.177447001750156 0.480168145971487 GO:0048306 calcium-dependent protein binding 12/2080 80/18639 0.15 1.34415865384615 0.177521448103465 0.480168145971487 GO:0015616 DNA translocase activity 21/2080 152/18639 0.138157894736842 1.23804086538462 0.178399436041788 0.480426551445867 GO:0140674 ATP-dependent histone chaperone activity 21/2080 152/18639 0.138157894736842 1.23804086538462 0.178399436041788 0.480426551445867 GO:0048487 beta-tubulin binding 7/2080 42/18639 0.166666666666667 1.49350961538462 0.182430852995972 0.490208068881956 GO:0038024 cargo receptor activity 10/2080 65/18639 0.153846153846154 1.37862426035503 0.18419288790687 0.492786201197465 GO:0120013 lipid transfer activity 10/2080 65/18639 0.153846153846154 1.37862426035503 0.18419288790687 0.492786201197465 GO:0046982 protein heterodimerization activity 47/2080 369/18639 0.127371273712737 1.14138133208255 0.185812491915795 0.496038565375208 GO:0046625 sphingolipid binding 5/2080 28/18639 0.178571428571429 1.60018887362637 0.196430328144405 0.52324608017642 GO:0004175 endopeptidase activity 51/2080 405/18639 0.125925925925926 1.12842948717949 0.197050254566854 0.523761282701509 GO:0008375 acetylglucosaminyltransferase activity 7/2080 43/18639 0.162790697674419 1.45877683363148 0.198405879900082 0.525094468814712 GO:0008195 phosphatidate phosphatase activity 3/2080 14/18639 0.214285714285714 1.92022664835165 0.19968983463882 0.525094468814712 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 3/2080 14/18639 0.214285714285714 1.92022664835165 0.19968983463882 0.525094468814712 GO:0032454 histone H3K9 demethylase activity 3/2080 14/18639 0.214285714285714 1.92022664835165 0.19968983463882 0.525094468814712 GO:0044548 S100 protein binding 3/2080 14/18639 0.214285714285714 1.92022664835165 0.19968983463882 0.525094468814712 GO:0008170 N-methyltransferase activity 14/2080 98/18639 0.142857142857143 1.2801510989011 0.200779726968649 0.526103312058797 GO:0010314 phosphatidylinositol-5-phosphate binding 4/2080 21/18639 0.19047619047619 1.70686813186813 0.200930336608775 0.526103312058797 GO:0140767 enzyme-substrate adaptor activity 19/2080 139/18639 0.136690647482014 1.22489277808522 0.205936980148455 0.538065131111282 GO:0001664 G protein-coupled receptor binding 38/2080 297/18639 0.127946127946128 1.14653263403263 0.206786690644259 0.539138123378239 GO:0015459 potassium channel regulator activity 9/2080 59/18639 0.152542372881356 1.36694100391134 0.207663127135772 0.539588806941955 GO:0045505 dynein intermediate chain binding 6/2080 36/18639 0.166666666666667 1.49350961538462 0.207838359677154 0.539588806941955 GO:0140713 histone chaperone activity 22/2080 164/18639 0.134146341463415 1.20209310506567 0.209321836195949 0.542293702212289 GO:0072341 modified amino acid binding 13/2080 91/18639 0.142857142857143 1.2801510989011 0.211863700211742 0.547723418652671 GO:0106222 lncRNA binding 5/2080 29/18639 0.172413793103448 1.5450099469496 0.217143026261388 0.56019251312812 GO:0030159 signaling receptor complex adaptor activity 8/2080 52/18639 0.153846153846154 1.37862426035503 0.219290177177467 0.564545781077419 GO:0043130 ubiquitin binding 14/2080 100/18639 0.14 1.25454807692308 0.222436860053474 0.571448669760807 GO:0043178 alcohol binding 13/2080 92/18639 0.141304347826087 1.26623641304348 0.223321016647664 0.57252235583159 GO:0008970 phospholipase A1 activity 4/2080 22/18639 0.181818181818182 1.62928321678322 0.225451344361814 0.574300524282307 GO:0031683 G-protein beta/gamma-subunit complex binding 4/2080 22/18639 0.181818181818182 1.62928321678322 0.225451344361814 0.574300524282307 GO:0140035 ubiquitin-like protein reader activity 4/2080 22/18639 0.181818181818182 1.62928321678322 0.225451344361814 0.574300524282307 GO:0023023 MHC protein complex binding 6/2080 37/18639 0.162162162162162 1.45314449064449 0.226430238603128 0.574300524282307 GO:0004089 carbonate dehydratase activity 3/2080 15/18639 0.2 1.79221153846154 0.23026653987655 0.574300524282307 GO:0004559 alpha-mannosidase activity 3/2080 15/18639 0.2 1.79221153846154 0.23026653987655 0.574300524282307 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 3/2080 15/18639 0.2 1.79221153846154 0.23026653987655 0.574300524282307 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 3/2080 15/18639 0.2 1.79221153846154 0.23026653987655 0.574300524282307 GO:0004953 icosanoid receptor activity 3/2080 15/18639 0.2 1.79221153846154 0.23026653987655 0.574300524282307 GO:0005523 tropomyosin binding 3/2080 15/18639 0.2 1.79221153846154 0.23026653987655 0.574300524282307 GO:0042809 nuclear vitamin D receptor binding 3/2080 15/18639 0.2 1.79221153846154 0.23026653987655 0.574300524282307 GO:0050780 dopamine receptor binding 3/2080 15/18639 0.2 1.79221153846154 0.23026653987655 0.574300524282307 GO:0120283 protein serine/threonine kinase binding 3/2080 15/18639 0.2 1.79221153846154 0.23026653987655 0.574300524282307 GO:0016757 glycosyltransferase activity 34/2080 267/18639 0.127340823970037 1.1411084701815 0.230562018299005 0.574300524282307 GO:0008146 sulfotransferase activity 8/2080 53/18639 0.150943396226415 1.35261248185776 0.234970167794274 0.583060651157222 GO:0051213 dioxygenase activity 13/2080 93/18639 0.139784946236559 1.25262096774194 0.235028519806861 0.583060651157222 GO:0031624 ubiquitin conjugating enzyme binding 5/2080 30/18639 0.166666666666667 1.49350961538462 0.238490795068622 0.589269006728908 GO:0098918 structural constituent of synapse 5/2080 30/18639 0.166666666666667 1.49350961538462 0.238490795068622 0.589269006728908 GO:0015171 amino acid transmembrane transporter activity 14/2080 102/18639 0.137254901960784 1.22994909502262 0.245027853895697 0.604205230088183 GO:0043531 ADP binding 6/2080 38/18639 0.157894736842105 1.41490384615385 0.245530340861747 0.60423097911468 GO:0004180 carboxypeptidase activity 7/2080 46/18639 0.152173913043478 1.36363921404682 0.249272082798278 0.605969622455973 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 7/2080 46/18639 0.152173913043478 1.36363921404682 0.249272082798278 0.605969622455973 GO:0030276 clathrin binding 7/2080 46/18639 0.152173913043478 1.36363921404682 0.249272082798278 0.605969622455973 GO:0043021 ribonucleoprotein complex binding 23/2080 177/18639 0.129943502824859 1.16443122555411 0.249403790895828 0.605969622455973 GO:0004022 alcohol dehydrogenase (NAD+) activity 4/2080 23/18639 0.173913043478261 1.55844481605351 0.250677987139767 0.605969622455973 GO:0005283 amino acid:sodium symporter activity 4/2080 23/18639 0.173913043478261 1.55844481605351 0.250677987139767 0.605969622455973 GO:0016849 phosphorus-oxygen lyase activity 4/2080 23/18639 0.173913043478261 1.55844481605351 0.250677987139767 0.605969622455973 GO:0031681 G-protein beta-subunit binding 4/2080 23/18639 0.173913043478261 1.55844481605351 0.250677987139767 0.605969622455973 GO:0140103 catalytic activity, acting on a glycoprotein 4/2080 23/18639 0.173913043478261 1.55844481605351 0.250677987139767 0.605969622455973 GO:0070325 lipoprotein particle receptor binding 5/2080 31/18639 0.161290322580645 1.44533188585608 0.260376235702731 0.623806687981346 GO:0004708 MAP kinase kinase activity 3/2080 16/18639 0.1875 1.68019831730769 0.261612739666444 0.623806687981346 GO:0005024 transforming growth factor beta receptor activity 3/2080 16/18639 0.1875 1.68019831730769 0.261612739666444 0.623806687981346 GO:0005324 long-chain fatty acid transmembrane transporter activity 3/2080 16/18639 0.1875 1.68019831730769 0.261612739666444 0.623806687981346 GO:0015562 efflux transmembrane transporter activity 3/2080 16/18639 0.1875 1.68019831730769 0.261612739666444 0.623806687981346 GO:0015923 mannosidase activity 3/2080 16/18639 0.1875 1.68019831730769 0.261612739666444 0.623806687981346 GO:0055102 lipase inhibitor activity 3/2080 16/18639 0.1875 1.68019831730769 0.261612739666444 0.623806687981346 GO:0008194 UDP-glycosyltransferase activity 19/2080 145/18639 0.131034482758621 1.1742075596817 0.262721900458397 0.625237391013395 GO:0061749 forked DNA-dependent helicase activity 7/2080 47/18639 0.148936170212766 1.33462561374795 0.267050088267708 0.633083993036188 GO:1990518 single-stranded 3'-5' DNA helicase activity 7/2080 47/18639 0.148936170212766 1.33462561374795 0.267050088267708 0.633083993036188 GO:0000287 magnesium ion binding 29/2080 230/18639 0.126086956521739 1.1298724916388 0.269573865820868 0.637835659398894 GO:0004896 cytokine receptor activity 13/2080 96/18639 0.135416666666667 1.2134765625 0.271510375687812 0.641182194893525 GO:0140597 protein carrier chaperone 24/2080 188/18639 0.127659574468085 1.14396481178396 0.272247698323722 0.641689392594108 GO:0005540 hyaluronic acid binding 4/2080 24/18639 0.166666666666667 1.49350961538462 0.276453447618896 0.647871819992374 GO:0050431 transforming growth factor beta binding 4/2080 24/18639 0.166666666666667 1.49350961538462 0.276453447618896 0.647871819992374 GO:0050699 WW domain binding 4/2080 24/18639 0.166666666666667 1.49350961538462 0.276453447618896 0.647871819992374 GO:0016758 hexosyltransferase activity 25/2080 197/18639 0.126903553299492 1.1371900624756 0.277050857379619 0.648035148308898 GO:0042910 xenobiotic transmembrane transporter activity 5/2080 32/18639 0.15625 1.40016526442308 0.282701941273644 0.652091849309134 GO:0120015 sterol transfer activity 5/2080 32/18639 0.15625 1.40016526442308 0.282701941273644 0.652091849309134 GO:0140142 nucleocytoplasmic carrier activity 5/2080 32/18639 0.15625 1.40016526442308 0.282701941273644 0.652091849309134 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 16/2080 122/18639 0.131147540983607 1.17522068095839 0.284425356451963 0.652091849309134 GO:0032451 demethylase activity 6/2080 40/18639 0.15 1.34415865384615 0.28498814118948 0.652091849309134 GO:0061791 GTPase motor activity 6/2080 40/18639 0.15 1.34415865384615 0.28498814118948 0.652091849309134 GO:1990606 membrane scission GTPase motor activity 6/2080 40/18639 0.15 1.34415865384615 0.28498814118948 0.652091849309134 GO:0009378 four-way junction helicase activity 7/2080 48/18639 0.145833333333333 1.30682091346154 0.285157429217431 0.652091849309134 GO:0032266 phosphatidylinositol-3-phosphate binding 7/2080 48/18639 0.145833333333333 1.30682091346154 0.285157429217431 0.652091849309134 GO:0036121 double-stranded DNA helicase activity 7/2080 48/18639 0.145833333333333 1.30682091346154 0.285157429217431 0.652091849309134 GO:0043138 3'-5' DNA helicase activity 7/2080 48/18639 0.145833333333333 1.30682091346154 0.285157429217431 0.652091849309134 GO:0140693 molecular condensate scaffold activity 7/2080 48/18639 0.145833333333333 1.30682091346154 0.285157429217431 0.652091849309134 GO:0015101 organic cation transmembrane transporter activity 11/2080 81/18639 0.135802469135802 1.21693376068376 0.291254055914377 0.657566070667206 GO:0030971 receptor tyrosine kinase binding 11/2080 81/18639 0.135802469135802 1.21693376068376 0.291254055914377 0.657566070667206 GO:0004659 prenyltransferase activity 3/2080 17/18639 0.176470588235294 1.58136312217195 0.293441536421522 0.657566070667206 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 3/2080 17/18639 0.176470588235294 1.58136312217195 0.293441536421522 0.657566070667206 GO:0005092 GDP-dissociation inhibitor activity 3/2080 17/18639 0.176470588235294 1.58136312217195 0.293441536421522 0.657566070667206 GO:0008429 phosphatidylethanolamine binding 3/2080 17/18639 0.176470588235294 1.58136312217195 0.293441536421522 0.657566070667206 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 3/2080 17/18639 0.176470588235294 1.58136312217195 0.293441536421522 0.657566070667206 GO:0015278 intracellularly gated calcium channel activity 3/2080 17/18639 0.176470588235294 1.58136312217195 0.293441536421522 0.657566070667206 GO:0016805 dipeptidase activity 3/2080 17/18639 0.176470588235294 1.58136312217195 0.293441536421522 0.657566070667206 GO:0019198 transmembrane receptor protein phosphatase activity 3/2080 17/18639 0.176470588235294 1.58136312217195 0.293441536421522 0.657566070667206 GO:0045236 CXCR chemokine receptor binding 3/2080 17/18639 0.176470588235294 1.58136312217195 0.293441536421522 0.657566070667206 GO:0042626 ATPase-coupled transmembrane transporter activity 13/2080 98/18639 0.13265306122449 1.18871173469388 0.29681324085891 0.657979119377158 GO:0008139 nuclear localization sequence binding 4/2080 25/18639 0.16 1.43376923076923 0.302625910125434 0.657979119377158 GO:0008483 transaminase activity 4/2080 25/18639 0.16 1.43376923076923 0.302625910125434 0.657979119377158 GO:0015662 P-type ion transporter activity 4/2080 25/18639 0.16 1.43376923076923 0.302625910125434 0.657979119377158 GO:0019706 protein-cysteine S-palmitoyltransferase activity 4/2080 25/18639 0.16 1.43376923076923 0.302625910125434 0.657979119377158 GO:0019707 protein-cysteine S-acyltransferase activity 4/2080 25/18639 0.16 1.43376923076923 0.302625910125434 0.657979119377158 GO:0140358 P-type transmembrane transporter activity 4/2080 25/18639 0.16 1.43376923076923 0.302625910125434 0.657979119377158 GO:0140318 protein transporter activity 6/2080 41/18639 0.146341463414634 1.31137429643527 0.305211225775583 0.657979119377158 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 5/2080 33/18639 0.151515151515152 1.35773601398601 0.305371662469098 0.657979119377158 GO:0071889 14-3-3 protein binding 5/2080 33/18639 0.151515151515152 1.35773601398601 0.305371662469098 0.657979119377158 GO:0003680 minor groove of adenine-thymine-rich DNA binding 2/2080 10/18639 0.2 1.79221153846154 0.30900352290277 0.657979119377158 GO:0004862 cAMP-dependent protein kinase inhibitor activity 2/2080 10/18639 0.2 1.79221153846154 0.30900352290277 0.657979119377158 GO:0005381 iron ion transmembrane transporter activity 2/2080 10/18639 0.2 1.79221153846154 0.30900352290277 0.657979119377158 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 2/2080 10/18639 0.2 1.79221153846154 0.30900352290277 0.657979119377158 GO:0015203 polyamine transmembrane transporter activity 2/2080 10/18639 0.2 1.79221153846154 0.30900352290277 0.657979119377158 GO:0015924 mannosyl-oligosaccharide mannosidase activity 2/2080 10/18639 0.2 1.79221153846154 0.30900352290277 0.657979119377158 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 2/2080 10/18639 0.2 1.79221153846154 0.30900352290277 0.657979119377158 GO:0032052 bile acid binding 2/2080 10/18639 0.2 1.79221153846154 0.30900352290277 0.657979119377158 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 2/2080 10/18639 0.2 1.79221153846154 0.30900352290277 0.657979119377158 GO:0043121 neurotrophin binding 2/2080 10/18639 0.2 1.79221153846154 0.30900352290277 0.657979119377158 GO:0045322 unmethylated CpG binding 2/2080 10/18639 0.2 1.79221153846154 0.30900352290277 0.657979119377158 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 2/2080 10/18639 0.2 1.79221153846154 0.30900352290277 0.657979119377158 GO:0050815 phosphoserine residue binding 2/2080 10/18639 0.2 1.79221153846154 0.30900352290277 0.657979119377158 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 2/2080 10/18639 0.2 1.79221153846154 0.30900352290277 0.657979119377158 GO:0140135 mechanosensitive monoatomic cation channel activity 2/2080 10/18639 0.2 1.79221153846154 0.30900352290277 0.657979119377158 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 2/2080 10/18639 0.2 1.79221153846154 0.30900352290277 0.657979119377158 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 2/2080 10/18639 0.2 1.79221153846154 0.30900352290277 0.657979119377158 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 2/2080 10/18639 0.2 1.79221153846154 0.30900352290277 0.657979119377158 GO:0003684 damaged DNA binding 10/2080 74/18639 0.135135135135135 1.21095374220374 0.309700269543972 0.657979119377158 GO:0031491 nucleosome binding 10/2080 74/18639 0.135135135135135 1.21095374220374 0.309700269543972 0.657979119377158 GO:0017116 single-stranded DNA helicase activity 8/2080 58/18639 0.137931034482759 1.23600795755968 0.318190562660584 0.674849759839718 GO:0000900 mRNA regulatory element binding translation repressor activity 3/2080 18/18639 0.166666666666667 1.49350961538462 0.325490820491679 0.680924578473222 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 3/2080 18/18639 0.166666666666667 1.49350961538462 0.325490820491679 0.680924578473222 GO:0004706 JUN kinase kinase kinase activity 3/2080 18/18639 0.166666666666667 1.49350961538462 0.325490820491679 0.680924578473222 GO:0004970 glutamate-gated receptor activity 3/2080 18/18639 0.166666666666667 1.49350961538462 0.325490820491679 0.680924578473222 GO:0022851 GABA-gated chloride ion channel activity 3/2080 18/18639 0.166666666666667 1.49350961538462 0.325490820491679 0.680924578473222 GO:0031690 adrenergic receptor binding 3/2080 18/18639 0.166666666666667 1.49350961538462 0.325490820491679 0.680924578473222 GO:0034185 apolipoprotein binding 3/2080 18/18639 0.166666666666667 1.49350961538462 0.325490820491679 0.680924578473222 GO:0070628 proteasome binding 3/2080 18/18639 0.166666666666667 1.49350961538462 0.325490820491679 0.680924578473222 GO:0052866 phosphatidylinositol phosphate phosphatase activity 5/2080 34/18639 0.147058823529412 1.31780260180995 0.328291325602806 0.684746089763795 GO:0005112 Notch binding 4/2080 26/18639 0.153846153846154 1.37862426035503 0.329050313612859 0.684746089763795 GO:0008066 glutamate receptor activity 4/2080 26/18639 0.153846153846154 1.37862426035503 0.329050313612859 0.684746089763795 GO:0099106 ion channel regulator activity 20/2080 160/18639 0.125 1.12013221153846 0.329547995969384 0.684746089763795 GO:0016500 protein-hormone receptor activity 9/2080 67/18639 0.134328358208955 1.20372416762342 0.330141262315426 0.684820050884025 GO:0051117 ATPase binding 11/2080 84/18639 0.130952380952381 1.17347184065934 0.334110015403642 0.691883809301302 GO:0016597 amino acid binding 7/2080 51/18639 0.137254901960784 1.22994909502262 0.340954982474114 0.704719464527388 GO:0031406 carboxylic acid binding 23/2080 187/18639 0.122994652406417 1.10216217605923 0.342349681523295 0.704719464527388 GO:0003774 cytoskeletal motor activity 19/2080 153/18639 0.124183006535948 1.11281108597285 0.346099355177524 0.704719464527388 GO:0008200 ion channel inhibitor activity 6/2080 43/18639 0.13953488372093 1.2503801431127 0.346312795510002 0.704719464527388 GO:0003777 microtubule motor activity 9/2080 68/18639 0.132352941176471 1.18602234162896 0.346431884884924 0.704719464527388 GO:0008238 exopeptidase activity 13/2080 102/18639 0.127450980392157 1.14209558823529 0.349196056953167 0.704719464527388 GO:0005154 epidermal growth factor receptor binding 5/2080 35/18639 0.142857142857143 1.2801510989011 0.351369904971088 0.704719464527388 GO:0004016 adenylate cyclase activity 2/2080 11/18639 0.181818181818182 1.62928321678322 0.351948612055216 0.704719464527388 GO:0004143 ATP-dependent diacylglycerol kinase activity 2/2080 11/18639 0.181818181818182 1.62928321678322 0.351948612055216 0.704719464527388 GO:0008172 S-methyltransferase activity 2/2080 11/18639 0.181818181818182 1.62928321678322 0.351948612055216 0.704719464527388 GO:0008432 JUN kinase binding 2/2080 11/18639 0.181818181818182 1.62928321678322 0.351948612055216 0.704719464527388 GO:0008503 benzodiazepine receptor activity 2/2080 11/18639 0.181818181818182 1.62928321678322 0.351948612055216 0.704719464527388 GO:0008526 phosphatidylinositol transfer activity 2/2080 11/18639 0.181818181818182 1.62928321678322 0.351948612055216 0.704719464527388 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 2/2080 11/18639 0.181818181818182 1.62928321678322 0.351948612055216 0.704719464527388 GO:0019206 nucleoside kinase activity 2/2080 11/18639 0.181818181818182 1.62928321678322 0.351948612055216 0.704719464527388 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 2/2080 11/18639 0.181818181818182 1.62928321678322 0.351948612055216 0.704719464527388 GO:0034511 U3 snoRNA binding 2/2080 11/18639 0.181818181818182 1.62928321678322 0.351948612055216 0.704719464527388 GO:0048407 platelet-derived growth factor binding 2/2080 11/18639 0.181818181818182 1.62928321678322 0.351948612055216 0.704719464527388 GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 2/2080 11/18639 0.181818181818182 1.62928321678322 0.351948612055216 0.704719464527388 GO:0003724 RNA helicase activity 10/2080 77/18639 0.12987012987013 1.16377372627373 0.355553142124903 0.704719464527388 GO:0004890 GABA-A receptor activity 3/2080 19/18639 0.157894736842105 1.41490384615385 0.357524614332706 0.704719464527388 GO:0005229 intracellularly calcium-gated chloride channel activity 3/2080 19/18639 0.157894736842105 1.41490384615385 0.357524614332706 0.704719464527388 GO:0005346 purine ribonucleotide transmembrane transporter activity 3/2080 19/18639 0.157894736842105 1.41490384615385 0.357524614332706 0.704719464527388 GO:0008574 plus-end-directed microtubule motor activity 3/2080 19/18639 0.157894736842105 1.41490384615385 0.357524614332706 0.704719464527388 GO:0015245 fatty acid transmembrane transporter activity 3/2080 19/18639 0.157894736842105 1.41490384615385 0.357524614332706 0.704719464527388 GO:0022840 leak channel activity 3/2080 19/18639 0.157894736842105 1.41490384615385 0.357524614332706 0.704719464527388 GO:0022842 narrow pore channel activity 3/2080 19/18639 0.157894736842105 1.41490384615385 0.357524614332706 0.704719464527388 GO:0050145 nucleoside monophosphate kinase activity 3/2080 19/18639 0.157894736842105 1.41490384615385 0.357524614332706 0.704719464527388 GO:0097001 ceramide binding 3/2080 19/18639 0.157894736842105 1.41490384615385 0.357524614332706 0.704719464527388 GO:0141147 intracellularly calcium-gated channel activity 3/2080 19/18639 0.157894736842105 1.41490384615385 0.357524614332706 0.704719464527388 GO:0043177 organic acid binding 23/2080 189/18639 0.121693121693122 1.09049908424908 0.361954539690664 0.71230797233996 GO:0016248 channel inhibitor activity 6/2080 44/18639 0.136363636363636 1.22196241258741 0.367061893162925 0.720051125885099 GO:0019205 nucleobase-containing compound kinase activity 6/2080 44/18639 0.136363636363636 1.22196241258741 0.367061893162925 0.720051125885099 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 8/2080 61/18639 0.131147540983607 1.17522068095839 0.370585603075135 0.724648281172399 GO:0019905 syntaxin binding 8/2080 61/18639 0.131147540983607 1.17522068095839 0.370585603075135 0.724648281172399 GO:0016409 palmitoyltransferase activity 5/2080 36/18639 0.138888888888889 1.24459134615385 0.374520154212045 0.729610763429852 GO:0044390 ubiquitin-like protein conjugating enzyme binding 5/2080 36/18639 0.138888888888889 1.24459134615385 0.374520154212045 0.729610763429852 GO:0005246 calcium channel regulator activity 7/2080 53/18639 0.132075471698113 1.18353592162554 0.378888730971314 0.729610763429852 GO:0005544 calcium-dependent phospholipid binding 7/2080 53/18639 0.132075471698113 1.18353592162554 0.378888730971314 0.729610763429852 GO:0017046 peptide hormone binding 7/2080 53/18639 0.132075471698113 1.18353592162554 0.378888730971314 0.729610763429852 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 4/2080 28/18639 0.142857142857143 1.2801510989011 0.382116274510097 0.729610763429852 GO:0016407 acetyltransferase activity 12/2080 96/18639 0.125 1.12013221153846 0.384164709975891 0.729610763429852 GO:0008186 ATP-dependent activity, acting on RNA 10/2080 79/18639 0.126582278481013 1.13431110029211 0.386633930224344 0.729610763429852 GO:0042605 peptide antigen binding 6/2080 45/18639 0.133333333333333 1.19480769230769 0.387860173734975 0.729610763429852 GO:0141110 transporter inhibitor activity 6/2080 45/18639 0.133333333333333 1.19480769230769 0.387860173734975 0.729610763429852 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 3/2080 20/18639 0.15 1.34415865384615 0.389333440954081 0.729610763429852 GO:0031418 L-ascorbic acid binding 3/2080 20/18639 0.15 1.34415865384615 0.389333440954081 0.729610763429852 GO:0043024 ribosomal small subunit binding 3/2080 20/18639 0.15 1.34415865384615 0.389333440954081 0.729610763429852 GO:0052745 inositol phosphate phosphatase activity 3/2080 20/18639 0.15 1.34415865384615 0.389333440954081 0.729610763429852 GO:0004032 aldose reductase (NADPH) activity 2/2080 12/18639 0.166666666666667 1.49350961538462 0.393918514783381 0.729610763429852 GO:0005025 transforming growth factor beta receptor activity, type I 2/2080 12/18639 0.166666666666667 1.49350961538462 0.393918514783381 0.729610763429852 GO:0005026 transforming growth factor beta receptor activity, type II 2/2080 12/18639 0.166666666666667 1.49350961538462 0.393918514783381 0.729610763429852 GO:0008179 adenylate cyclase binding 2/2080 12/18639 0.166666666666667 1.49350961538462 0.393918514783381 0.729610763429852 GO:0008603 cAMP-dependent protein kinase regulator activity 2/2080 12/18639 0.166666666666667 1.49350961538462 0.393918514783381 0.729610763429852 GO:0016208 AMP binding 2/2080 12/18639 0.166666666666667 1.49350961538462 0.393918514783381 0.729610763429852 GO:0016361 activin receptor activity, type I 2/2080 12/18639 0.166666666666667 1.49350961538462 0.393918514783381 0.729610763429852 GO:0016362 activin receptor activity, type II 2/2080 12/18639 0.166666666666667 1.49350961538462 0.393918514783381 0.729610763429852 GO:0017002 activin receptor activity 2/2080 12/18639 0.166666666666667 1.49350961538462 0.393918514783381 0.729610763429852 GO:0017166 vinculin binding 2/2080 12/18639 0.166666666666667 1.49350961538462 0.393918514783381 0.729610763429852 GO:0035197 siRNA binding 2/2080 12/18639 0.166666666666667 1.49350961538462 0.393918514783381 0.729610763429852 GO:0035251 UDP-glucosyltransferase activity 2/2080 12/18639 0.166666666666667 1.49350961538462 0.393918514783381 0.729610763429852 GO:0043047 single-stranded telomeric DNA binding 2/2080 12/18639 0.166666666666667 1.49350961538462 0.393918514783381 0.729610763429852 GO:0070679 inositol 1,4,5 trisphosphate binding 2/2080 12/18639 0.166666666666667 1.49350961538462 0.393918514783381 0.729610763429852 GO:0097677 STAT family protein binding 2/2080 12/18639 0.166666666666667 1.49350961538462 0.393918514783381 0.729610763429852 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 2/2080 12/18639 0.166666666666667 1.49350961538462 0.393918514783381 0.729610763429852 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 2/2080 12/18639 0.166666666666667 1.49350961538462 0.393918514783381 0.729610763429852 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 2/2080 12/18639 0.166666666666667 1.49350961538462 0.393918514783381 0.729610763429852 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 2/2080 12/18639 0.166666666666667 1.49350961538462 0.393918514783381 0.729610763429852 GO:1990459 transferrin receptor binding 2/2080 12/18639 0.166666666666667 1.49350961538462 0.393918514783381 0.729610763429852 GO:1990817 poly(A) RNA polymerase activity 2/2080 12/18639 0.166666666666667 1.49350961538462 0.393918514783381 0.729610763429852 GO:0019213 deacetylase activity 5/2080 37/18639 0.135135135135135 1.21095374220374 0.397659203525938 0.734829072010339 GO:0051287 NAD binding 7/2080 54/18639 0.12962962962963 1.16161858974359 0.39793268150397 0.734829072010339 GO:0061135 endopeptidase regulator activity 22/2080 184/18639 0.119565217391304 1.07143081103679 0.399095959008502 0.735870627120781 GO:1901682 sulfur compound transmembrane transporter activity 8/2080 63/18639 0.126984126984127 1.13791208791209 0.405900022927365 0.743189228021192 GO:0003785 actin monomer binding 4/2080 29/18639 0.137931034482759 1.23600795755968 0.40851199422989 0.743189228021192 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 4/2080 29/18639 0.137931034482759 1.23600795755968 0.40851199422989 0.743189228021192 GO:0005416 amino acid:monoatomic cation symporter activity 4/2080 29/18639 0.137931034482759 1.23600795755968 0.40851199422989 0.743189228021192 GO:0016417 S-acyltransferase activity 4/2080 29/18639 0.137931034482759 1.23600795755968 0.40851199422989 0.743189228021192 GO:0035250 UDP-galactosyltransferase activity 4/2080 29/18639 0.137931034482759 1.23600795755968 0.40851199422989 0.743189228021192 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 4/2080 29/18639 0.137931034482759 1.23600795755968 0.40851199422989 0.743189228021192 GO:0097472 cyclin-dependent protein kinase activity 4/2080 29/18639 0.137931034482759 1.23600795755968 0.40851199422989 0.743189228021192 GO:0099604 ligand-gated calcium channel activity 4/2080 29/18639 0.137931034482759 1.23600795755968 0.40851199422989 0.743189228021192 GO:0008236 serine-type peptidase activity 23/2080 194/18639 0.118556701030928 1.06239343774782 0.411806437915814 0.74807441680565 GO:0016247 channel regulator activity 20/2080 168/18639 0.119047619047619 1.06679258241758 0.414757312211896 0.752321978428668 GO:0001618 virus receptor activity 10/2080 81/18639 0.123456790123457 1.10630341880342 0.417883500586727 0.756874540885695 GO:0005248 voltage-gated sodium channel activity 3/2080 21/18639 0.142857142857143 1.2801510989011 0.420733958344965 0.75756788980589 GO:0008373 sialyltransferase activity 3/2080 21/18639 0.142857142857143 1.2801510989011 0.420733958344965 0.75756788980589 GO:0009931 calcium-dependent protein serine/threonine kinase activity 3/2080 21/18639 0.142857142857143 1.2801510989011 0.420733958344965 0.75756788980589 GO:0009975 cyclase activity 3/2080 21/18639 0.142857142857143 1.2801510989011 0.420733958344965 0.75756788980589 GO:0043495 protein-membrane adaptor activity 6/2080 47/18639 0.127659574468085 1.14396481178396 0.429370089683933 0.769126306919312 GO:0099095 ligand-gated monoatomic anion channel activity 6/2080 47/18639 0.127659574468085 1.14396481178396 0.429370089683933 0.769126306919312 GO:0140272 exogenous protein binding 10/2080 82/18639 0.121951219512195 1.09281191369606 0.433509183758388 0.769126306919312 GO:0004866 endopeptidase inhibitor activity 19/2080 161/18639 0.118012422360248 1.05751612517917 0.434268758424314 0.769126306919312 GO:0008035 high-density lipoprotein particle binding 2/2080 13/18639 0.153846153846154 1.37862426035503 0.434596118862411 0.769126306919312 GO:0070123 transforming growth factor beta receptor activity, type III 2/2080 13/18639 0.153846153846154 1.37862426035503 0.434596118862411 0.769126306919312 GO:0071837 HMG box domain binding 2/2080 13/18639 0.153846153846154 1.37862426035503 0.434596118862411 0.769126306919312 GO:0140410 monoatomic cation:bicarbonate symporter activity 2/2080 13/18639 0.153846153846154 1.37862426035503 0.434596118862411 0.769126306919312 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 2/2080 13/18639 0.153846153846154 1.37862426035503 0.434596118862411 0.769126306919312 GO:0001968 fibronectin binding 4/2080 30/18639 0.133333333333333 1.19480769230769 0.434669101793162 0.769126306919312 GO:0008106 alcohol dehydrogenase (NADP+) activity 4/2080 30/18639 0.133333333333333 1.19480769230769 0.434669101793162 0.769126306919312 GO:0016769 transferase activity, transferring nitrogenous groups 4/2080 30/18639 0.133333333333333 1.19480769230769 0.434669101793162 0.769126306919312 GO:0141108 transporter regulator activity 20/2080 170/18639 0.117647058823529 1.05424208144796 0.436417110290995 0.771108217895455 GO:0016776 phosphotransferase activity, phosphate group as acceptor 5/2080 39/18639 0.128205128205128 1.14885355029586 0.443596818991796 0.782667950749893 GO:0001540 amyloid-beta binding 10/2080 83/18639 0.120481927710843 1.07964550509731 0.449103411652301 0.788627307764286 GO:0016879 ligase activity, forming carbon-nitrogen bonds 6/2080 48/18639 0.125 1.12013221153846 0.449971898322005 0.788627307764286 GO:0015377 chloride:monoatomic cation symporter activity 3/2080 22/18639 0.136363636363636 1.22196241258741 0.451568055289673 0.788627307764286 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 3/2080 22/18639 0.136363636363636 1.22196241258741 0.451568055289673 0.788627307764286 GO:0016881 acid-amino acid ligase activity 3/2080 22/18639 0.136363636363636 1.22196241258741 0.451568055289673 0.788627307764286 GO:0030021 extracellular matrix structural constituent conferring compression resistance 3/2080 22/18639 0.136363636363636 1.22196241258741 0.451568055289673 0.788627307764286 GO:0061133 endopeptidase activator activity 3/2080 22/18639 0.136363636363636 1.22196241258741 0.451568055289673 0.788627307764286 GO:0017171 serine hydrolase activity 23/2080 198/18639 0.116161616161616 1.04093094405594 0.45211207220363 0.788627307764286 GO:0072349 modified amino acid transmembrane transporter activity 4/2080 31/18639 0.129032258064516 1.15626550868486 0.460490267139892 0.802102195812465 GO:0004860 protein kinase inhibitor activity 10/2080 84/18639 0.119047619047619 1.06679258241758 0.464643059794012 0.808189344797516 GO:0005313 L-glutamate transmembrane transporter activity 2/2080 14/18639 0.142857142857143 1.2801510989011 0.473747166233009 0.813652475712077 GO:0005347 ATP transmembrane transporter activity 2/2080 14/18639 0.142857142857143 1.2801510989011 0.473747166233009 0.813652475712077 GO:0008331 high voltage-gated calcium channel activity 2/2080 14/18639 0.142857142857143 1.2801510989011 0.473747166233009 0.813652475712077 GO:0034236 protein kinase A catalytic subunit binding 2/2080 14/18639 0.142857142857143 1.2801510989011 0.473747166233009 0.813652475712077 GO:0042813 Wnt receptor activity 2/2080 14/18639 0.142857142857143 1.2801510989011 0.473747166233009 0.813652475712077 GO:0046030 inositol trisphosphate phosphatase activity 2/2080 14/18639 0.142857142857143 1.2801510989011 0.473747166233009 0.813652475712077 GO:0098821 BMP receptor activity 2/2080 14/18639 0.142857142857143 1.2801510989011 0.473747166233009 0.813652475712077 GO:0098847 sequence-specific single stranded DNA binding 2/2080 14/18639 0.142857142857143 1.2801510989011 0.473747166233009 0.813652475712077 GO:1990825 sequence-specific mRNA binding 2/2080 14/18639 0.142857142857143 1.2801510989011 0.473747166233009 0.813652475712077 GO:0050840 extracellular matrix binding 8/2080 67/18639 0.119402985074627 1.06997703788749 0.47615933295284 0.815902789584734 GO:0042562 hormone binding 11/2080 94/18639 0.117021276595745 1.04863441080196 0.481680947941861 0.815902789584734 GO:0000295 adenine nucleotide transmembrane transporter activity 3/2080 23/18639 0.130434782608696 1.16883361204013 0.48170156551216 0.815902789584734 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 3/2080 23/18639 0.130434782608696 1.16883361204013 0.48170156551216 0.815902789584734 GO:0005212 structural constituent of eye lens 3/2080 23/18639 0.130434782608696 1.16883361204013 0.48170156551216 0.815902789584734 GO:0008171 O-methyltransferase activity 3/2080 23/18639 0.130434782608696 1.16883361204013 0.48170156551216 0.815902789584734 GO:0016917 GABA receptor activity 3/2080 23/18639 0.130434782608696 1.16883361204013 0.48170156551216 0.815902789584734 GO:0043274 phospholipase binding 3/2080 23/18639 0.130434782608696 1.16883361204013 0.48170156551216 0.815902789584734 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 3/2080 23/18639 0.130434782608696 1.16883361204013 0.48170156551216 0.815902789584734 GO:0099186 structural constituent of postsynapse 3/2080 23/18639 0.130434782608696 1.16883361204013 0.48170156551216 0.815902789584734 GO:0005253 monoatomic anion channel activity 12/2080 103/18639 0.116504854368932 1.04400672143391 0.483069128346971 0.817092134449146 GO:0043022 ribosome binding 13/2080 112/18639 0.116071428571429 1.04012276785714 0.48430804457769 0.817357808316686 GO:0003697 single-stranded DNA binding 14/2080 121/18639 0.115702479338843 1.03681659249841 0.485425403569526 0.817357808316686 GO:0071813 lipoprotein particle binding 4/2080 32/18639 0.125 1.12013221153846 0.485888599406499 0.817357808316686 GO:0071814 protein-lipid complex binding 4/2080 32/18639 0.125 1.12013221153846 0.485888599406499 0.817357808316686 GO:0008237 metallopeptidase activity 21/2080 184/18639 0.114130434782609 1.02272941053512 0.491132933959058 0.825049579892919 GO:0031593 polyubiquitin modification-dependent protein binding 7/2080 59/18639 0.11864406779661 1.06317633637549 0.492179401233378 0.825678011905176 GO:0008509 monoatomic anion transmembrane transporter activity 17/2080 149/18639 0.114093959731544 1.02240255549819 0.499898068753192 0.837482712727039 GO:0005272 sodium channel activity 6/2080 51/18639 0.117647058823529 1.05424208144796 0.510573945358272 0.839252178123738 GO:0031492 nucleosomal DNA binding 5/2080 42/18639 0.119047619047619 1.06679258241758 0.510642393248782 0.839252178123738 GO:0008081 phosphoric diester hydrolase activity 10/2080 87/18639 0.114942528735632 1.03000663129973 0.51071599813486 0.839252178123738 GO:0019956 chemokine binding 4/2080 33/18639 0.121212121212121 1.08618881118881 0.510787487259934 0.839252178123738 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 3/2080 24/18639 0.125 1.12013221153846 0.511022725211197 0.839252178123738 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 3/2080 24/18639 0.125 1.12013221153846 0.511022725211197 0.839252178123738 GO:0004622 lysophospholipase activity 3/2080 24/18639 0.125 1.12013221153846 0.511022725211197 0.839252178123738 GO:0015149 hexose transmembrane transporter activity 3/2080 24/18639 0.125 1.12013221153846 0.511022725211197 0.839252178123738 GO:0019957 C-C chemokine binding 3/2080 24/18639 0.125 1.12013221153846 0.511022725211197 0.839252178123738 GO:0048027 mRNA 5'-UTR binding 3/2080 24/18639 0.125 1.12013221153846 0.511022725211197 0.839252178123738 GO:0055056 D-glucose transmembrane transporter activity 3/2080 24/18639 0.125 1.12013221153846 0.511022725211197 0.839252178123738 GO:0000774 adenyl-nucleotide exchange factor activity 2/2080 15/18639 0.133333333333333 1.19480769230769 0.511205724134003 0.839252178123738 GO:0017081 chloride channel regulator activity 2/2080 15/18639 0.133333333333333 1.19480769230769 0.511205724134003 0.839252178123738 GO:0031005 filamin binding 2/2080 15/18639 0.133333333333333 1.19480769230769 0.511205724134003 0.839252178123738 GO:0051371 muscle alpha-actinin binding 2/2080 15/18639 0.133333333333333 1.19480769230769 0.511205724134003 0.839252178123738 GO:0140104 molecular carrier activity 28/2080 249/18639 0.112449799196787 1.00766913809082 0.512965731700573 0.841017247701341 GO:0030414 peptidase inhibitor activity 19/2080 169/18639 0.112426035502959 1.00745619025944 0.522684576379164 0.855808879724818 GO:0000149 SNARE binding 12/2080 106/18639 0.113207547169811 1.01445936139332 0.524675303350461 0.857924464067065 GO:0016835 carbon-oxygen lyase activity 9/2080 79/18639 0.113924050632911 1.0208799902629 0.526584983683363 0.858760106192788 GO:0033293 monocarboxylic acid binding 9/2080 79/18639 0.113924050632911 1.0208799902629 0.526584983683363 0.858760106192788 GO:0016782 transferase activity, transferring sulphur-containing groups 8/2080 70/18639 0.114285714285714 1.02412087912088 0.527524385134338 0.859151120616668 GO:0016836 hydro-lyase activity 7/2080 61/18639 0.114754098360656 1.02831809583859 0.528705722697029 0.859934605923115 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 6/2080 52/18639 0.115384615384615 1.03396819526627 0.530229596641491 0.861272413592264 GO:0046943 carboxylic acid transmembrane transporter activity 21/2080 188/18639 0.111702127659574 1.00096921031097 0.532743653682346 0.864212954718521 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 4/2080 34/18639 0.117647058823529 1.05424208144796 0.535120308814217 0.866923138817756 GO:0005251 delayed rectifier potassium channel activity 3/2080 25/18639 0.12 1.07532692307692 0.539440472722891 0.86819515138101 GO:0005537 D-mannose binding 3/2080 25/18639 0.12 1.07532692307692 0.539440472722891 0.86819515138101 GO:0015271 outward rectifier potassium channel activity 3/2080 25/18639 0.12 1.07532692307692 0.539440472722891 0.86819515138101 GO:0015296 monoatomic anion:monoatomic cation symporter activity 3/2080 25/18639 0.12 1.07532692307692 0.539440472722891 0.86819515138101 GO:0120020 cholesterol transfer activity 3/2080 25/18639 0.12 1.07532692307692 0.539440472722891 0.86819515138101 GO:0005342 organic acid transmembrane transporter activity 21/2080 189/18639 0.111111111111111 0.995673076923077 0.543011843046511 0.871006964903104 GO:0008083 growth factor activity 18/2080 162/18639 0.111111111111111 0.995673076923077 0.545080422267983 0.871006964903104 GO:0005159 insulin-like growth factor receptor binding 2/2080 16/18639 0.125 1.12013221153846 0.546861864772226 0.871006964903104 GO:0015378 sodium:chloride symporter activity 2/2080 16/18639 0.125 1.12013221153846 0.546861864772226 0.871006964903104 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 2/2080 16/18639 0.125 1.12013221153846 0.546861864772226 0.871006964903104 GO:0022841 potassium ion leak channel activity 2/2080 16/18639 0.125 1.12013221153846 0.546861864772226 0.871006964903104 GO:0043023 ribosomal large subunit binding 2/2080 16/18639 0.125 1.12013221153846 0.546861864772226 0.871006964903104 GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 2/2080 16/18639 0.125 1.12013221153846 0.546861864772226 0.871006964903104 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 20/2080 181/18639 0.110497237569061 0.990172120696982 0.554084417850062 0.881367441865124 GO:0019210 kinase inhibitor activity 10/2080 90/18639 0.111111111111111 0.995673076923077 0.555550867084183 0.882556875523127 GO:0005343 organic acid:sodium symporter activity 4/2080 35/18639 0.114285714285714 1.02412087912088 0.558830038342363 0.885475209141189 GO:0061631 ubiquitin conjugating enzyme activity 4/2080 35/18639 0.114285714285714 1.02412087912088 0.558830038342363 0.885475209141189 GO:0002020 protease binding 15/2080 136/18639 0.110294117647059 0.988351951357466 0.559880928857196 0.885997139995666 GO:0140097 catalytic activity, acting on DNA 37/2080 336/18639 0.110119047619048 0.986783138736264 0.560686281257625 0.886129669735345 GO:0004112 cyclic-nucleotide phosphodiesterase activity 3/2080 26/18639 0.115384615384615 1.03396819526627 0.566882667389418 0.890194265414584 GO:0008198 ferrous iron binding 3/2080 26/18639 0.115384615384615 1.03396819526627 0.566882667389418 0.890194265414584 GO:0015145 monosaccharide transmembrane transporter activity 3/2080 26/18639 0.115384615384615 1.03396819526627 0.566882667389418 0.890194265414584 GO:0015216 purine nucleotide transmembrane transporter activity 3/2080 26/18639 0.115384615384615 1.03396819526627 0.566882667389418 0.890194265414584 GO:0120014 phospholipid transfer activity 3/2080 26/18639 0.115384615384615 1.03396819526627 0.566882667389418 0.890194265414584 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 6/2080 54/18639 0.111111111111111 0.995673076923077 0.568501835358654 0.891596748174236 GO:0046915 transition metal ion transmembrane transporter activity 5/2080 45/18639 0.111111111111111 0.995673076923077 0.574142604786321 0.898785980249592 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 25/2080 229/18639 0.109170305676856 0.978281407457172 0.578117402725986 0.898785980249592 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 2/2080 17/18639 0.117647058823529 1.05424208144796 0.580651241885653 0.898785980249592 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 2/2080 17/18639 0.117647058823529 1.05424208144796 0.580651241885653 0.898785980249592 GO:0008569 minus-end-directed microtubule motor activity 2/2080 17/18639 0.117647058823529 1.05424208144796 0.580651241885653 0.898785980249592 GO:0030169 low-density lipoprotein particle binding 2/2080 17/18639 0.117647058823529 1.05424208144796 0.580651241885653 0.898785980249592 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 2/2080 17/18639 0.117647058823529 1.05424208144796 0.580651241885653 0.898785980249592 GO:0036041 long-chain fatty acid binding 2/2080 17/18639 0.117647058823529 1.05424208144796 0.580651241885653 0.898785980249592 GO:0045125 bioactive lipid receptor activity 2/2080 17/18639 0.117647058823529 1.05424208144796 0.580651241885653 0.898785980249592 GO:0051787 misfolded protein binding 2/2080 17/18639 0.117647058823529 1.05424208144796 0.580651241885653 0.898785980249592 GO:0004033 aldo-keto reductase (NADPH) activity 4/2080 36/18639 0.111111111111111 0.995673076923077 0.581868773858653 0.898785980249592 GO:0004190 aspartic-type endopeptidase activity 4/2080 36/18639 0.111111111111111 0.995673076923077 0.581868773858653 0.898785980249592 GO:0048029 monosaccharide binding 8/2080 74/18639 0.108108108108108 0.968762993762994 0.592872500361883 0.910706730499178 GO:0004364 glutathione transferase activity 3/2080 27/18639 0.111111111111111 0.995673076923077 0.593294286970149 0.910706730499178 GO:0005044 scavenger receptor activity 3/2080 27/18639 0.111111111111111 0.995673076923077 0.593294286970149 0.910706730499178 GO:0008320 protein transmembrane transporter activity 3/2080 27/18639 0.111111111111111 0.995673076923077 0.593294286970149 0.910706730499178 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 3/2080 27/18639 0.111111111111111 0.995673076923077 0.593294286970149 0.910706730499178 GO:0030291 protein serine/threonine kinase inhibitor activity 5/2080 46/18639 0.108695652173913 0.974028010033445 0.594324826421789 0.911149671468111 GO:0004252 serine-type endopeptidase activity 19/2080 176/18639 0.107954545454545 0.967386909965035 0.596974931710313 0.914071341820779 GO:0160215 deacylase activity 7/2080 65/18639 0.107692307692308 0.965036982248521 0.598365234151145 0.915014877772994 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 18/2080 167/18639 0.107784431137725 0.965862505757715 0.599081402059843 0.915014877772994 GO:0042805 actinin binding 4/2080 37/18639 0.108108108108108 0.968762993762994 0.604197206626255 0.920462211709692 GO:0070001 aspartic-type peptidase activity 4/2080 37/18639 0.108108108108108 0.968762993762994 0.604197206626255 0.920462211709692 GO:0000400 four-way junction DNA binding 2/2080 18/18639 0.111111111111111 0.995673076923077 0.6125462945599 0.920462211709692 GO:0003746 translation elongation factor activity 2/2080 18/18639 0.111111111111111 0.995673076923077 0.6125462945599 0.920462211709692 GO:0008409 5'-3' exonuclease activity 2/2080 18/18639 0.111111111111111 0.995673076923077 0.6125462945599 0.920462211709692 GO:0015373 monoatomic anion:sodium symporter activity 2/2080 18/18639 0.111111111111111 0.995673076923077 0.6125462945599 0.920462211709692 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 2/2080 18/18639 0.111111111111111 0.995673076923077 0.6125462945599 0.920462211709692 GO:0016854 racemase and epimerase activity 2/2080 18/18639 0.111111111111111 0.995673076923077 0.6125462945599 0.920462211709692 GO:0017075 syntaxin-1 binding 2/2080 18/18639 0.111111111111111 0.995673076923077 0.6125462945599 0.920462211709692 GO:0017128 phospholipid scramblase activity 2/2080 18/18639 0.111111111111111 0.995673076923077 0.6125462945599 0.920462211709692 GO:0035615 clathrin adaptor activity 2/2080 18/18639 0.111111111111111 0.995673076923077 0.6125462945599 0.920462211709692 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 2/2080 18/18639 0.111111111111111 0.995673076923077 0.6125462945599 0.920462211709692 GO:1901611 phosphatidylglycerol binding 2/2080 18/18639 0.111111111111111 0.995673076923077 0.6125462945599 0.920462211709692 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 13/2080 122/18639 0.10655737704918 0.954866803278688 0.613141766432026 0.920462211709692 GO:0005504 fatty acid binding 5/2080 47/18639 0.106382978723404 0.953304009819967 0.613962295081058 0.920568618265616 GO:0005242 inward rectifier potassium channel activity 3/2080 28/18639 0.107142857142857 0.960113324175824 0.618635648465355 0.923067528937371 GO:0051119 sugar transmembrane transporter activity 3/2080 28/18639 0.107142857142857 0.960113324175824 0.618635648465355 0.923067528937371 GO:0051393 alpha-actinin binding 3/2080 28/18639 0.107142857142857 0.960113324175824 0.618635648465355 0.923067528937371 GO:0051959 dynein light intermediate chain binding 3/2080 28/18639 0.107142857142857 0.960113324175824 0.618635648465355 0.923067528937371 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 14/2080 132/18639 0.106060606060606 0.95041520979021 0.621409348093865 0.926080921673867 GO:0000146 microfilament motor activity 4/2080 38/18639 0.105263157894737 0.943269230769231 0.625784050793776 0.930342390284209 GO:0042887 amide transmembrane transporter activity 4/2080 38/18639 0.105263157894737 0.943269230769231 0.625784050793776 0.930342390284209 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 7/2080 67/18639 0.104477611940299 0.93622990815155 0.631123035510636 0.937145208714705 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 5/2080 48/18639 0.104166666666667 0.933443509615385 0.633030945866994 0.938842997010469 GO:0003756 protein disulfide isomerase activity 2/2080 19/18639 0.105263157894737 0.943269230769231 0.642548845174864 0.945458062017748 GO:0008381 mechanosensitive monoatomic ion channel activity 2/2080 19/18639 0.105263157894737 0.943269230769231 0.642548845174864 0.945458062017748 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 2/2080 19/18639 0.105263157894737 0.943269230769231 0.642548845174864 0.945458062017748 GO:0022821 solute:potassium antiporter activity 2/2080 19/18639 0.105263157894737 0.943269230769231 0.642548845174864 0.945458062017748 GO:0043395 heparan sulfate proteoglycan binding 2/2080 19/18639 0.105263157894737 0.943269230769231 0.642548845174864 0.945458062017748 GO:0046527 glucosyltransferase activity 2/2080 19/18639 0.105263157894737 0.943269230769231 0.642548845174864 0.945458062017748 GO:0004181 metallocarboxypeptidase activity 3/2080 29/18639 0.103448275862069 0.927005968169761 0.642880685492524 0.945458062017748 GO:0000217 DNA secondary structure binding 4/2080 39/18639 0.102564102564103 0.919082840236686 0.646605448714001 0.948663669080996 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 4/2080 39/18639 0.102564102564103 0.919082840236686 0.646605448714001 0.948663669080996 GO:0016763 pentosyltransferase activity 5/2080 49/18639 0.102040816326531 0.914393642072214 0.651511315334949 0.954720638700856 GO:0036002 pre-mRNA binding 6/2080 59/18639 0.101694915254237 0.911294002607562 0.656849710151357 0.96024346442751 GO:0015081 sodium ion transmembrane transporter activity 17/2080 164/18639 0.103658536585366 0.928890126641651 0.66375768415948 0.96024346442751 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 3/2080 30/18639 0.1 0.896105769230769 0.666015305903565 0.96024346442751 GO:0015215 nucleotide transmembrane transporter activity 3/2080 30/18639 0.1 0.896105769230769 0.666015305903565 0.96024346442751 GO:0031210 phosphatidylcholine binding 3/2080 30/18639 0.1 0.896105769230769 0.666015305903565 0.96024346442751 GO:0015144 carbohydrate transmembrane transporter activity 4/2080 40/18639 0.1 0.896105769230769 0.666644365067225 0.96024346442751 GO:0071949 FAD binding 4/2080 40/18639 0.1 0.896105769230769 0.666644365067225 0.96024346442751 GO:0032813 tumor necrosis factor receptor superfamily binding 5/2080 50/18639 0.1 0.896105769230769 0.669388264455026 0.96024346442751 GO:0001972 retinoic acid binding 2/2080 20/18639 0.1 0.896105769230769 0.670683890088285 0.96024346442751 GO:0016004 phospholipase activator activity 2/2080 20/18639 0.1 0.896105769230769 0.670683890088285 0.96024346442751 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 2/2080 20/18639 0.1 0.896105769230769 0.670683890088285 0.96024346442751 GO:0042277 peptide binding 26/2080 249/18639 0.104417670682731 0.935692771084337 0.671089485796793 0.96024346442751 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 6/2080 60/18639 0.1 0.896105769230769 0.673104034508492 0.96024346442751 GO:0140375 immune receptor activity 16/2080 156/18639 0.102564102564103 0.919082840236686 0.677916346758682 0.96024346442751 GO:0008514 organic anion transmembrane transporter activity 28/2080 269/18639 0.104089219330855 0.932749499571061 0.681653023766559 0.96024346442751 GO:0061650 ubiquitin-like protein conjugating enzyme activity 4/2080 41/18639 0.0975609756097561 0.874249530956848 0.685889980707957 0.96024346442751 GO:0008327 methyl-CpG binding 3/2080 31/18639 0.0967741935483871 0.867199131513648 0.688035845771101 0.96024346442751 GO:0047499 calcium-independent phospholipase A2 activity 3/2080 31/18639 0.0967741935483871 0.867199131513648 0.688035845771101 0.96024346442751 GO:0001094 TFIID-class transcription factor complex binding 1/2080 10/18639 0.1 0.896105769230769 0.693815483374587 0.96024346442751 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 1/2080 10/18639 0.1 0.896105769230769 0.693815483374587 0.96024346442751 GO:0004090 carbonyl reductase (NADPH) activity 1/2080 10/18639 0.1 0.896105769230769 0.693815483374587 0.96024346442751 GO:0004382 GDP phosphatase activity 1/2080 10/18639 0.1 0.896105769230769 0.693815483374587 0.96024346442751 GO:0005131 growth hormone receptor binding 1/2080 10/18639 0.1 0.896105769230769 0.693815483374587 0.96024346442751 GO:0008140 cAMP response element binding protein binding 1/2080 10/18639 0.1 0.896105769230769 0.693815483374587 0.96024346442751 GO:0008190 eukaryotic initiation factor 4E binding 1/2080 10/18639 0.1 0.896105769230769 0.693815483374587 0.96024346442751 GO:0008239 dipeptidyl-peptidase activity 1/2080 10/18639 0.1 0.896105769230769 0.693815483374587 0.96024346442751 GO:0008519 ammonium channel activity 1/2080 10/18639 0.1 0.896105769230769 0.693815483374587 0.96024346442751 GO:0016868 intramolecular phosphotransferase activity 1/2080 10/18639 0.1 0.896105769230769 0.693815483374587 0.96024346442751 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 1/2080 10/18639 0.1 0.896105769230769 0.693815483374587 0.96024346442751 GO:0030957 Tat protein binding 1/2080 10/18639 0.1 0.896105769230769 0.693815483374587 0.96024346442751 GO:0031434 mitogen-activated protein kinase kinase binding 1/2080 10/18639 0.1 0.896105769230769 0.693815483374587 0.96024346442751 GO:0031957 very long-chain fatty acid-CoA ligase activity 1/2080 10/18639 0.1 0.896105769230769 0.693815483374587 0.96024346442751 GO:0032356 oxidized DNA binding 1/2080 10/18639 0.1 0.896105769230769 0.693815483374587 0.96024346442751 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 1/2080 10/18639 0.1 0.896105769230769 0.693815483374587 0.96024346442751 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 1/2080 10/18639 0.1 0.896105769230769 0.693815483374587 0.96024346442751 GO:0043295 glutathione binding 1/2080 10/18639 0.1 0.896105769230769 0.693815483374587 0.96024346442751 GO:0043422 protein kinase B binding 1/2080 10/18639 0.1 0.896105769230769 0.693815483374587 0.96024346442751 GO:0050308 sugar-phosphatase activity 1/2080 10/18639 0.1 0.896105769230769 0.693815483374587 0.96024346442751 GO:0051864 histone H3K36 demethylase activity 1/2080 10/18639 0.1 0.896105769230769 0.693815483374587 0.96024346442751 GO:0070097 delta-catenin binding 1/2080 10/18639 0.1 0.896105769230769 0.693815483374587 0.96024346442751 GO:0070513 death domain binding 1/2080 10/18639 0.1 0.896105769230769 0.693815483374587 0.96024346442751 GO:0070739 protein-glutamic acid ligase activity 1/2080 10/18639 0.1 0.896105769230769 0.693815483374587 0.96024346442751 GO:0070740 tubulin-glutamic acid ligase activity 1/2080 10/18639 0.1 0.896105769230769 0.693815483374587 0.96024346442751 GO:0098505 G-rich strand telomeric DNA binding 1/2080 10/18639 0.1 0.896105769230769 0.693815483374587 0.96024346442751 GO:0099122 RNA polymerase II C-terminal domain binding 1/2080 10/18639 0.1 0.896105769230769 0.693815483374587 0.96024346442751 GO:1990763 arrestin family protein binding 1/2080 10/18639 0.1 0.896105769230769 0.693815483374587 0.96024346442751 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 2/2080 21/18639 0.0952380952380952 0.853434065934066 0.69699440921916 0.96024346442751 GO:0019200 carbohydrate kinase activity 2/2080 21/18639 0.0952380952380952 0.853434065934066 0.69699440921916 0.96024346442751 GO:0051428 peptide hormone receptor binding 2/2080 21/18639 0.0952380952380952 0.853434065934066 0.69699440921916 0.96024346442751 GO:0070182 DNA polymerase binding 2/2080 21/18639 0.0952380952380952 0.853434065934066 0.69699440921916 0.96024346442751 GO:0140312 cargo adaptor activity 2/2080 21/18639 0.0952380952380952 0.853434065934066 0.69699440921916 0.96024346442751 GO:0008307 structural constituent of muscle 4/2080 42/18639 0.0952380952380952 0.853434065934066 0.704337095177344 0.96024346442751 GO:0022884 macromolecule transmembrane transporter activity 3/2080 32/18639 0.09375 0.840099158653846 0.708947629877784 0.96024346442751 GO:0030515 snoRNA binding 3/2080 32/18639 0.09375 0.840099158653846 0.708947629877784 0.96024346442751 GO:0031369 translation initiation factor binding 3/2080 32/18639 0.09375 0.840099158653846 0.708947629877784 0.96024346442751 GO:0047498 calcium-dependent phospholipase A2 activity 3/2080 32/18639 0.09375 0.840099158653846 0.708947629877784 0.96024346442751 GO:0015079 potassium ion transmembrane transporter activity 16/2080 160/18639 0.1 0.896105769230769 0.716516205669717 0.96024346442751 GO:0022824 transmitter-gated monoatomic ion channel activity 6/2080 63/18639 0.0952380952380952 0.853434065934066 0.718829471345798 0.96024346442751 GO:0022835 transmitter-gated channel activity 6/2080 63/18639 0.0952380952380952 0.853434065934066 0.718829471345798 0.96024346442751 GO:0005254 chloride channel activity 8/2080 83/18639 0.0963855421686747 0.86371640407785 0.721268342317918 0.96024346442751 GO:0005245 voltage-gated calcium channel activity 4/2080 43/18639 0.0930232558139535 0.833586762075134 0.721985545068279 0.96024346442751 GO:0016853 isomerase activity 18/2080 180/18639 0.1 0.896105769230769 0.724459851863057 0.96024346442751 GO:0004857 enzyme inhibitor activity 43/2080 416/18639 0.103365384615385 0.926263174926035 0.72761388687628 0.96024346442751 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 1/2080 11/18639 0.0909090909090909 0.814641608391608 0.728002170506524 0.96024346442751 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 1/2080 11/18639 0.0909090909090909 0.814641608391608 0.728002170506524 0.96024346442751 GO:0003953 NAD+ nucleosidase activity 1/2080 11/18639 0.0909090909090909 0.814641608391608 0.728002170506524 0.96024346442751 GO:0005536 D-glucose binding 1/2080 11/18639 0.0909090909090909 0.814641608391608 0.728002170506524 0.96024346442751 GO:0008199 ferric iron binding 1/2080 11/18639 0.0909090909090909 0.814641608391608 0.728002170506524 0.96024346442751 GO:0015173 aromatic amino acid transmembrane transporter activity 1/2080 11/18639 0.0909090909090909 0.814641608391608 0.728002170506524 0.96024346442751 GO:0015217 ADP transmembrane transporter activity 1/2080 11/18639 0.0909090909090909 0.814641608391608 0.728002170506524 0.96024346442751 GO:0016176 superoxide-generating NADPH oxidase activator activity 1/2080 11/18639 0.0909090909090909 0.814641608391608 0.728002170506524 0.96024346442751 GO:0016594 glycine binding 1/2080 11/18639 0.0909090909090909 0.814641608391608 0.728002170506524 0.96024346442751 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 1/2080 11/18639 0.0909090909090909 0.814641608391608 0.728002170506524 0.96024346442751 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 1/2080 11/18639 0.0909090909090909 0.814641608391608 0.728002170506524 0.96024346442751 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 1/2080 11/18639 0.0909090909090909 0.814641608391608 0.728002170506524 0.96024346442751 GO:0019107 myristoyltransferase activity 1/2080 11/18639 0.0909090909090909 0.814641608391608 0.728002170506524 0.96024346442751 GO:0019203 carbohydrate phosphatase activity 1/2080 11/18639 0.0909090909090909 0.814641608391608 0.728002170506524 0.96024346442751 GO:0032050 clathrin heavy chain binding 1/2080 11/18639 0.0909090909090909 0.814641608391608 0.728002170506524 0.96024346442751 GO:0032404 mismatch repair complex binding 1/2080 11/18639 0.0909090909090909 0.814641608391608 0.728002170506524 0.96024346442751 GO:0035252 UDP-xylosyltransferase activity 1/2080 11/18639 0.0909090909090909 0.814641608391608 0.728002170506524 0.96024346442751 GO:0042285 xylosyltransferase activity 1/2080 11/18639 0.0909090909090909 0.814641608391608 0.728002170506524 0.96024346442751 GO:0042608 T cell receptor binding 1/2080 11/18639 0.0909090909090909 0.814641608391608 0.728002170506524 0.96024346442751 GO:0043522 leucine zipper domain binding 1/2080 11/18639 0.0909090909090909 0.814641608391608 0.728002170506524 0.96024346442751 GO:0047676 arachidonate-CoA ligase activity 1/2080 11/18639 0.0909090909090909 0.814641608391608 0.728002170506524 0.96024346442751 GO:0048185 activin binding 1/2080 11/18639 0.0909090909090909 0.814641608391608 0.728002170506524 0.96024346442751 GO:0050786 RAGE receptor binding 1/2080 11/18639 0.0909090909090909 0.814641608391608 0.728002170506524 0.96024346442751 GO:0050998 nitric-oxide synthase binding 1/2080 11/18639 0.0909090909090909 0.814641608391608 0.728002170506524 0.96024346442751 GO:0070697 activin receptor binding 1/2080 11/18639 0.0909090909090909 0.814641608391608 0.728002170506524 0.96024346442751 GO:0070990 snRNP binding 1/2080 11/18639 0.0909090909090909 0.814641608391608 0.728002170506524 0.96024346442751 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 1/2080 11/18639 0.0909090909090909 0.814641608391608 0.728002170506524 0.96024346442751 GO:0140537 transcription regulator activator activity 1/2080 11/18639 0.0909090909090909 0.814641608391608 0.728002170506524 0.96024346442751 GO:0180030 inositol phosphate kinase activity 1/2080 11/18639 0.0909090909090909 0.814641608391608 0.728002170506524 0.96024346442751 GO:1900750 oligopeptide binding 1/2080 11/18639 0.0909090909090909 0.814641608391608 0.728002170506524 0.96024346442751 GO:0050661 NADP binding 5/2080 54/18639 0.0925925925925926 0.829727564102564 0.734694152012385 0.966236190475177 GO:0005267 potassium channel activity 12/2080 124/18639 0.0967741935483871 0.867199131513648 0.741567676154532 0.966236190475177 GO:0003887 DNA-directed DNA polymerase activity 2/2080 23/18639 0.0869565217391304 0.779222408026756 0.744378518812104 0.966236190475177 GO:0004602 glutathione peroxidase activity 2/2080 23/18639 0.0869565217391304 0.779222408026756 0.744378518812104 0.966236190475177 GO:0016493 C-C chemokine receptor activity 2/2080 23/18639 0.0869565217391304 0.779222408026756 0.744378518812104 0.966236190475177 GO:0017134 fibroblast growth factor binding 2/2080 23/18639 0.0869565217391304 0.779222408026756 0.744378518812104 0.966236190475177 GO:0042171 lysophosphatidic acid acyltransferase activity 2/2080 23/18639 0.0869565217391304 0.779222408026756 0.744378518812104 0.966236190475177 GO:0071617 lysophospholipid acyltransferase activity 2/2080 23/18639 0.0869565217391304 0.779222408026756 0.744378518812104 0.966236190475177 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 2/2080 23/18639 0.0869565217391304 0.779222408026756 0.744378518812104 0.966236190475177 GO:0015035 protein-disulfide reductase activity 3/2080 34/18639 0.0882352941176471 0.790681561085973 0.7475033217517 0.966236190475177 GO:0016831 carboxy-lyase activity 3/2080 34/18639 0.0882352941176471 0.790681561085973 0.7475033217517 0.966236190475177 GO:0030332 cyclin binding 3/2080 34/18639 0.0882352941176471 0.790681561085973 0.7475033217517 0.966236190475177 GO:0090482 vitamin transmembrane transporter activity 3/2080 34/18639 0.0882352941176471 0.790681561085973 0.7475033217517 0.966236190475177 GO:0005506 iron ion binding 15/2080 154/18639 0.0974025974025974 0.872830294705295 0.749415467463416 0.966236190475177 GO:0000340 RNA 7-methylguanosine cap binding 1/2080 12/18639 0.0833333333333333 0.746754807692308 0.758373411935901 0.966236190475177 GO:0000995 RNA polymerase III general transcription initiation factor activity 1/2080 12/18639 0.0833333333333333 0.746754807692308 0.758373411935901 0.966236190475177 GO:0003720 telomerase activity 1/2080 12/18639 0.0833333333333333 0.746754807692308 0.758373411935901 0.966236190475177 GO:0003995 acyl-CoA dehydrogenase activity 1/2080 12/18639 0.0833333333333333 0.746754807692308 0.758373411935901 0.966236190475177 GO:0004000 adenosine deaminase activity 1/2080 12/18639 0.0833333333333333 0.746754807692308 0.758373411935901 0.966236190475177 GO:0004300 enoyl-CoA hydratase activity 1/2080 12/18639 0.0833333333333333 0.746754807692308 0.758373411935901 0.966236190475177 GO:0005247 voltage-gated chloride channel activity 1/2080 12/18639 0.0833333333333333 0.746754807692308 0.758373411935901 0.966236190475177 GO:0008504 monoamine transmembrane transporter activity 1/2080 12/18639 0.0833333333333333 0.746754807692308 0.758373411935901 0.966236190475177 GO:0015132 prostaglandin transmembrane transporter activity 1/2080 12/18639 0.0833333333333333 0.746754807692308 0.758373411935901 0.966236190475177 GO:0015269 calcium-activated potassium channel activity 1/2080 12/18639 0.0833333333333333 0.746754807692308 0.758373411935901 0.966236190475177 GO:0015368 calcium:monoatomic cation antiporter activity 1/2080 12/18639 0.0833333333333333 0.746754807692308 0.758373411935901 0.966236190475177 GO:0016273 arginine N-methyltransferase activity 1/2080 12/18639 0.0833333333333333 0.746754807692308 0.758373411935901 0.966236190475177 GO:0016274 protein-arginine N-methyltransferase activity 1/2080 12/18639 0.0833333333333333 0.746754807692308 0.758373411935901 0.966236190475177 GO:0016801 hydrolase activity, acting on ether bonds 1/2080 12/18639 0.0833333333333333 0.746754807692308 0.758373411935901 0.966236190475177 GO:0016803 ether hydrolase activity 1/2080 12/18639 0.0833333333333333 0.746754807692308 0.758373411935901 0.966236190475177 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 1/2080 12/18639 0.0833333333333333 0.746754807692308 0.758373411935901 0.966236190475177 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 1/2080 12/18639 0.0833333333333333 0.746754807692308 0.758373411935901 0.966236190475177 GO:0008235 metalloexopeptidase activity 6/2080 66/18639 0.0909090909090909 0.814641608391608 0.759918951539275 0.966236190475177 GO:0016779 nucleotidyltransferase activity 13/2080 136/18639 0.0955882352941176 0.856571691176471 0.762757934206436 0.966236190475177 GO:0170055 lipid transmembrane transporter activity 5/2080 56/18639 0.0892857142857143 0.800094436813187 0.763601771712471 0.966236190475177 GO:0015293 symporter activity 14/2080 146/18639 0.0958904109589041 0.859279504741833 0.764661122785466 0.966236190475177 GO:0004623 phospholipase A2 activity 3/2080 35/18639 0.0857142857142857 0.768090659340659 0.765191442071326 0.966236190475177 GO:0034061 DNA polymerase activity 3/2080 35/18639 0.0857142857142857 0.768090659340659 0.765191442071326 0.966236190475177 GO:0005315 phosphate transmembrane transporter activity 2/2080 24/18639 0.0833333333333333 0.746754807692308 0.765592681866732 0.966236190475177 GO:0042625 ATPase-coupled ion transmembrane transporter activity 2/2080 24/18639 0.0833333333333333 0.746754807692308 0.765592681866732 0.966236190475177 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 2/2080 24/18639 0.0833333333333333 0.746754807692308 0.765592681866732 0.966236190475177 GO:0046961 proton-transporting ATPase activity, rotational mechanism 2/2080 24/18639 0.0833333333333333 0.746754807692308 0.765592681866732 0.966236190475177 GO:0060229 lipase activator activity 2/2080 24/18639 0.0833333333333333 0.746754807692308 0.765592681866732 0.966236190475177 GO:0015085 calcium ion transmembrane transporter activity 14/2080 147/18639 0.0952380952380952 0.853434065934066 0.773300443128256 0.973174328471383 GO:0005249 voltage-gated potassium channel activity 9/2080 98/18639 0.0918367346938776 0.822954277864992 0.778655215017167 0.973174328471383 GO:0005484 SNAP receptor activity 3/2080 36/18639 0.0833333333333333 0.746754807692308 0.781857139181568 0.973174328471383 GO:0003707 nuclear steroid receptor activity 2/2080 25/18639 0.08 0.716884615384615 0.7852580913575 0.973174328471383 GO:0047617 fatty acyl-CoA hydrolase activity 2/2080 25/18639 0.08 0.716884615384615 0.7852580913575 0.973174328471383 GO:0003964 RNA-directed DNA polymerase activity 1/2080 13/18639 0.0769230769230769 0.689312130177515 0.785354853025359 0.973174328471383 GO:0004535 poly(A)-specific ribonuclease activity 1/2080 13/18639 0.0769230769230769 0.689312130177515 0.785354853025359 0.973174328471383 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 1/2080 13/18639 0.0769230769230769 0.689312130177515 0.785354853025359 0.973174328471383 GO:0004993 G protein-coupled serotonin receptor activity 1/2080 13/18639 0.0769230769230769 0.689312130177515 0.785354853025359 0.973174328471383 GO:0008253 5'-nucleotidase activity 1/2080 13/18639 0.0769230769230769 0.689312130177515 0.785354853025359 0.973174328471383 GO:0015651 quaternary ammonium group transmembrane transporter activity 1/2080 13/18639 0.0769230769230769 0.689312130177515 0.785354853025359 0.973174328471383 GO:0019104 DNA N-glycosylase activity 1/2080 13/18639 0.0769230769230769 0.689312130177515 0.785354853025359 0.973174328471383 GO:0030955 potassium ion binding 1/2080 13/18639 0.0769230769230769 0.689312130177515 0.785354853025359 0.973174328471383 GO:0031432 titin binding 1/2080 13/18639 0.0769230769230769 0.689312130177515 0.785354853025359 0.973174328471383 GO:0035673 oligopeptide transmembrane transporter activity 1/2080 13/18639 0.0769230769230769 0.689312130177515 0.785354853025359 0.973174328471383 GO:0039706 co-receptor binding 1/2080 13/18639 0.0769230769230769 0.689312130177515 0.785354853025359 0.973174328471383 GO:0045159 myosin II binding 1/2080 13/18639 0.0769230769230769 0.689312130177515 0.785354853025359 0.973174328471383 GO:0071714 icosanoid transmembrane transporter activity 1/2080 13/18639 0.0769230769230769 0.689312130177515 0.785354853025359 0.973174328471383 GO:0015370 solute:sodium symporter activity 7/2080 79/18639 0.0886075949367089 0.794017770204479 0.792526803132646 0.978199508864161 GO:0033218 amide binding 24/2080 247/18639 0.097165991902834 0.870710059171598 0.793539635612611 0.978199508864161 GO:0001637 G protein-coupled chemoattractant receptor activity 2/2080 26/18639 0.0769230769230769 0.689312130177515 0.803456043354841 0.978199508864161 GO:0004435 phosphatidylinositol phospholipase C activity 2/2080 26/18639 0.0769230769230769 0.689312130177515 0.803456043354841 0.978199508864161 GO:0004950 chemokine receptor activity 2/2080 26/18639 0.0769230769230769 0.689312130177515 0.803456043354841 0.978199508864161 GO:0005227 calcium-activated cation channel activity 2/2080 26/18639 0.0769230769230769 0.689312130177515 0.803456043354841 0.978199508864161 GO:0016289 acyl-CoA hydrolase activity 2/2080 26/18639 0.0769230769230769 0.689312130177515 0.803456043354841 0.978199508864161 GO:0030247 polysaccharide binding 2/2080 26/18639 0.0769230769230769 0.689312130177515 0.803456043354841 0.978199508864161 GO:0070006 metalloaminopeptidase activity 2/2080 26/18639 0.0769230769230769 0.689312130177515 0.803456043354841 0.978199508864161 GO:0097602 cullin family protein binding 2/2080 26/18639 0.0769230769230769 0.689312130177515 0.803456043354841 0.978199508864161 GO:0016829 lyase activity 19/2080 200/18639 0.095 0.851300480769231 0.803801922626742 0.978199508864161 GO:0015108 chloride transmembrane transporter activity 11/2080 121/18639 0.0909090909090909 0.814641608391608 0.805500633278514 0.978199508864161 GO:0008028 monocarboxylic acid transmembrane transporter activity 6/2080 70/18639 0.0857142857142857 0.768090659340659 0.807576612120225 0.978199508864161 GO:0004065 arylsulfatase activity 1/2080 14/18639 0.0714285714285714 0.640075549450549 0.809324675086309 0.978199508864161 GO:0008474 palmitoyl-(protein) hydrolase activity 1/2080 14/18639 0.0714285714285714 0.640075549450549 0.809324675086309 0.978199508864161 GO:0008494 translation activator activity 1/2080 14/18639 0.0714285714285714 0.640075549450549 0.809324675086309 0.978199508864161 GO:0015386 potassium:proton antiporter activity 1/2080 14/18639 0.0714285714285714 0.640075549450549 0.809324675086309 0.978199508864161 GO:0019992 diacylglycerol binding 1/2080 14/18639 0.0714285714285714 0.640075549450549 0.809324675086309 0.978199508864161 GO:0030983 mismatched DNA binding 1/2080 14/18639 0.0714285714285714 0.640075549450549 0.809324675086309 0.978199508864161 GO:0031404 chloride ion binding 1/2080 14/18639 0.0714285714285714 0.640075549450549 0.809324675086309 0.978199508864161 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 1/2080 14/18639 0.0714285714285714 0.640075549450549 0.809324675086309 0.978199508864161 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 1/2080 14/18639 0.0714285714285714 0.640075549450549 0.809324675086309 0.978199508864161 GO:0098599 palmitoyl hydrolase activity 1/2080 14/18639 0.0714285714285714 0.640075549450549 0.809324675086309 0.978199508864161 GO:1901474 azole transmembrane transporter activity 1/2080 14/18639 0.0714285714285714 0.640075549450549 0.809324675086309 0.978199508864161 GO:1901612 cardiolipin binding 1/2080 14/18639 0.0714285714285714 0.640075549450549 0.809324675086309 0.978199508864161 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 3/2080 38/18639 0.0789473684210526 0.707451923076923 0.812254355422628 0.980775170559476 GO:0005385 zinc ion transmembrane transporter activity 2/2080 27/18639 0.0740740740740741 0.663782051282051 0.820268983865616 0.984100071763381 GO:0016405 CoA-ligase activity 2/2080 27/18639 0.0740740740740741 0.663782051282051 0.820268983865616 0.984100071763381 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 2/2080 27/18639 0.0740740740740741 0.663782051282051 0.820268983865616 0.984100071763381 GO:0015605 organophosphate ester transmembrane transporter activity 4/2080 50/18639 0.08 0.716884615384615 0.823960151114654 0.984100071763381 GO:0015026 coreceptor activity 5/2080 61/18639 0.0819672131147541 0.734512925598991 0.825334875871795 0.984100071763381 GO:0004467 long-chain fatty acid-CoA ligase activity 1/2080 15/18639 0.0666666666666667 0.597403846153846 0.830618885868616 0.984100071763381 GO:0005402 carbohydrate:monoatomic cation symporter activity 1/2080 15/18639 0.0666666666666667 0.597403846153846 0.830618885868616 0.984100071763381 GO:0008242 omega peptidase activity 1/2080 15/18639 0.0666666666666667 0.597403846153846 0.830618885868616 0.984100071763381 GO:0008252 nucleotidase activity 1/2080 15/18639 0.0666666666666667 0.597403846153846 0.830618885868616 0.984100071763381 GO:0015556 C4-dicarboxylate transmembrane transporter activity 1/2080 15/18639 0.0666666666666667 0.597403846153846 0.830618885868616 0.984100071763381 GO:0015929 hexosaminidase activity 1/2080 15/18639 0.0666666666666667 0.597403846153846 0.830618885868616 0.984100071763381 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 1/2080 15/18639 0.0666666666666667 0.597403846153846 0.830618885868616 0.984100071763381 GO:0016846 carbon-sulfur lyase activity 1/2080 15/18639 0.0666666666666667 0.597403846153846 0.830618885868616 0.984100071763381 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 1/2080 15/18639 0.0666666666666667 0.597403846153846 0.830618885868616 0.984100071763381 GO:0045504 dynein heavy chain binding 1/2080 15/18639 0.0666666666666667 0.597403846153846 0.830618885868616 0.984100071763381 GO:0047372 monoacylglycerol lipase activity 1/2080 15/18639 0.0666666666666667 0.597403846153846 0.830618885868616 0.984100071763381 GO:0008135 translation factor activity, RNA binding 7/2080 83/18639 0.0843373493975904 0.755751853568119 0.83253514048393 0.984100071763381 GO:0015103 inorganic anion transmembrane transporter activity 15/2080 165/18639 0.0909090909090909 0.814641608391608 0.834287953958871 0.984100071763381 GO:0005048 signal sequence binding 4/2080 51/18639 0.0784313725490196 0.702828054298642 0.835646062661109 0.984100071763381 GO:0016830 carbon-carbon lyase activity 4/2080 51/18639 0.0784313725490196 0.702828054298642 0.835646062661109 0.984100071763381 GO:0050698 proteoglycan sulfotransferase activity 2/2080 28/18639 0.0714285714285714 0.640075549450549 0.835779240434867 0.984100071763381 GO:0051537 2 iron, 2 sulfur cluster binding 2/2080 28/18639 0.0714285714285714 0.640075549450549 0.835779240434867 0.984100071763381 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 6/2080 73/18639 0.0821917808219178 0.736525289778714 0.838213911103048 0.984100071763381 GO:0004177 aminopeptidase activity 3/2080 40/18639 0.075 0.672079326923077 0.838983895785555 0.984100071763381 GO:0004532 RNA exonuclease activity 3/2080 40/18639 0.075 0.672079326923077 0.838983895785555 0.984100071763381 GO:0015036 disulfide oxidoreductase activity 3/2080 40/18639 0.075 0.672079326923077 0.838983895785555 0.984100071763381 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 3/2080 40/18639 0.075 0.672079326923077 0.838983895785555 0.984100071763381 GO:0050997 quaternary ammonium group binding 3/2080 40/18639 0.075 0.672079326923077 0.838983895785555 0.984100071763381 GO:0015399 primary active transmembrane transporter activity 15/2080 166/18639 0.0903614457831325 0.809734128822984 0.840791149820216 0.984100071763381 GO:0180051 translation factor activity 7/2080 84/18639 0.0833333333333333 0.746754807692308 0.841520279493955 0.984100071763381 GO:0015294 solute:monoatomic cation symporter activity 10/2080 116/18639 0.0862068965517241 0.772504973474801 0.846792142024399 0.984100071763381 GO:0003688 DNA replication origin binding 1/2080 16/18639 0.0625 0.560066105769231 0.849536020608376 0.984100071763381 GO:0015385 sodium:proton antiporter activity 1/2080 16/18639 0.0625 0.560066105769231 0.849536020608376 0.984100071763381 GO:0016722 oxidoreductase activity, acting on metal ions 1/2080 16/18639 0.0625 0.560066105769231 0.849536020608376 0.984100071763381 GO:0017070 U6 snRNA binding 1/2080 16/18639 0.0625 0.560066105769231 0.849536020608376 0.984100071763381 GO:0030275 LRR domain binding 1/2080 16/18639 0.0625 0.560066105769231 0.849536020608376 0.984100071763381 GO:0031435 mitogen-activated protein kinase kinase kinase binding 1/2080 16/18639 0.0625 0.560066105769231 0.849536020608376 0.984100071763381 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 1/2080 16/18639 0.0625 0.560066105769231 0.849536020608376 0.984100071763381 GO:0097027 ubiquitin-protein transferase activator activity 1/2080 16/18639 0.0625 0.560066105769231 0.849536020608376 0.984100071763381 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 1/2080 16/18639 0.0625 0.560066105769231 0.849536020608376 0.984100071763381 GO:0004629 phospholipase C activity 2/2080 29/18639 0.0689655172413793 0.618003978779841 0.850068022282448 0.984100071763381 GO:0043236 laminin binding 2/2080 29/18639 0.0689655172413793 0.618003978779841 0.850068022282448 0.984100071763381 GO:0001530 lipopolysaccharide binding 3/2080 41/18639 0.0731707317073171 0.655687148217636 0.851070257502207 0.984100071763381 GO:0008227 G protein-coupled amine receptor activity 3/2080 41/18639 0.0731707317073171 0.655687148217636 0.851070257502207 0.984100071763381 GO:0140828 metal cation:monoatomic cation antiporter activity 3/2080 41/18639 0.0731707317073171 0.655687148217636 0.851070257502207 0.984100071763381 GO:0016860 intramolecular oxidoreductase activity 4/2080 53/18639 0.0754716981132075 0.676306240928882 0.857073154900467 0.989178415618208 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 4/2080 53/18639 0.0754716981132075 0.676306240928882 0.857073154900467 0.989178415618208 GO:0022839 monoatomic ion-gated channel activity 2/2080 30/18639 0.0666666666666667 0.597403846153846 0.863214644880939 0.990240323219998 GO:0033612 receptor serine/threonine kinase binding 2/2080 30/18639 0.0666666666666667 0.597403846153846 0.863214644880939 0.990240323219998 GO:0005132 type I interferon receptor binding 1/2080 17/18639 0.0588235294117647 0.527121040723982 0.866341319278546 0.990240323219998 GO:0008484 sulfuric ester hydrolase activity 1/2080 17/18639 0.0588235294117647 0.527121040723982 0.866341319278546 0.990240323219998 GO:0009881 photoreceptor activity 1/2080 17/18639 0.0588235294117647 0.527121040723982 0.866341319278546 0.990240323219998 GO:0015347 sodium-independent organic anion transmembrane transporter activity 1/2080 17/18639 0.0588235294117647 0.527121040723982 0.866341319278546 0.990240323219998 GO:0016018 cyclosporin A binding 1/2080 17/18639 0.0588235294117647 0.527121040723982 0.866341319278546 0.990240323219998 GO:0017110 nucleoside diphosphate phosphatase activity 1/2080 17/18639 0.0588235294117647 0.527121040723982 0.866341319278546 0.990240323219998 GO:0070402 NADPH binding 1/2080 17/18639 0.0588235294117647 0.527121040723982 0.866341319278546 0.990240323219998 GO:0070492 oligosaccharide binding 1/2080 17/18639 0.0588235294117647 0.527121040723982 0.866341319278546 0.990240323219998 GO:0017069 snRNA binding 4/2080 54/18639 0.0740740740740741 0.663782051282051 0.866863475131513 0.990240323219998 GO:0003730 mRNA 3'-UTR binding 24/2080 262/18639 0.0916030534351145 0.820860246623605 0.873404299513671 0.99520455100714 GO:0005184 neuropeptide hormone activity 2/2080 31/18639 0.0645161290322581 0.578132754342432 0.875295941371273 0.99520455100714 GO:0005452 solute:inorganic anion antiporter activity 2/2080 31/18639 0.0645161290322581 0.578132754342432 0.875295941371273 0.99520455100714 GO:0016411 acylglycerol O-acyltransferase activity 2/2080 31/18639 0.0645161290322581 0.578132754342432 0.875295941371273 0.99520455100714 GO:0016878 acid-thiol ligase activity 2/2080 31/18639 0.0645161290322581 0.578132754342432 0.875295941371273 0.99520455100714 GO:0008374 O-acyltransferase activity 4/2080 55/18639 0.0727272727272727 0.651713286713287 0.876071758663451 0.99520455100714 GO:0005262 calcium channel activity 11/2080 131/18639 0.083969465648855 0.752455226071638 0.877385385201305 0.995775649747877 GO:0008308 voltage-gated monoatomic anion channel activity 1/2080 18/18639 0.0555555555555556 0.497836538461538 0.881270438379643 0.995907720680925 GO:0015280 ligand-gated sodium channel activity 1/2080 18/18639 0.0555555555555556 0.497836538461538 0.881270438379643 0.995907720680925 GO:1990381 ubiquitin-specific protease binding 1/2080 18/18639 0.0555555555555556 0.497836538461538 0.881270438379643 0.995907720680925 GO:0030547 signaling receptor inhibitor activity 3/2080 44/18639 0.0681818181818182 0.610981206293706 0.882693534561149 0.995907720680925 GO:0008168 methyltransferase activity 18/2080 204/18639 0.0882352941176471 0.790681561085973 0.883150045050404 0.995907720680925 GO:0030170 pyridoxal phosphate binding 4/2080 56/18639 0.0714285714285714 0.640075549450549 0.884723296121219 0.995907720680925 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 4/2080 56/18639 0.0714285714285714 0.640075549450549 0.884723296121219 0.995907720680925 GO:0022843 voltage-gated monoatomic cation channel activity 12/2080 143/18639 0.0839160839160839 0.751976869284562 0.886230871973663 0.995907720680925 GO:0015106 bicarbonate transmembrane transporter activity 2/2080 32/18639 0.0625 0.560066105769231 0.886385828804172 0.995907720680925 GO:0160041 neuropeptide activity 2/2080 32/18639 0.0625 0.560066105769231 0.886385828804172 0.995907720680925 GO:0016741 transferase activity, transferring one-carbon groups 19/2080 215/18639 0.0883720930232558 0.791907423971377 0.887111670324743 0.995907720680925 GO:0015932 nucleobase-containing compound transmembrane transporter activity 4/2080 57/18639 0.0701754385964912 0.628846153846154 0.89284332874757 0.995907720680925 GO:0070279 vitamin B6 binding 4/2080 57/18639 0.0701754385964912 0.628846153846154 0.89284332874757 0.995907720680925 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 7/2080 91/18639 0.0769230769230769 0.689312130177515 0.894053472619434 0.995907720680925 GO:0008301 DNA binding, bending 1/2080 19/18639 0.0526315789473684 0.471634615384615 0.894532749113241 0.995907720680925 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 1/2080 19/18639 0.0526315789473684 0.471634615384615 0.894532749113241 0.995907720680925 GO:0030506 ankyrin binding 1/2080 19/18639 0.0526315789473684 0.471634615384615 0.894532749113241 0.995907720680925 GO:0042834 peptidoglycan binding 1/2080 19/18639 0.0526315789473684 0.471634615384615 0.894532749113241 0.995907720680925 GO:0070003 threonine-type peptidase activity 1/2080 19/18639 0.0526315789473684 0.471634615384615 0.894532749113241 0.995907720680925 GO:0099589 serotonin receptor activity 1/2080 19/18639 0.0526315789473684 0.471634615384615 0.894532749113241 0.995907720680925 GO:0120227 acyl-CoA binding 1/2080 19/18639 0.0526315789473684 0.471634615384615 0.894532749113241 0.995907720680925 GO:0042923 neuropeptide binding 2/2080 33/18639 0.0606060606060606 0.543094405594406 0.89655500200834 0.997255020349857 GO:0030246 carbohydrate binding 25/2080 280/18639 0.0892857142857143 0.800094436813187 0.904736898042016 0.999999999995441 GO:0019825 oxygen binding 2/2080 34/18639 0.0588235294117647 0.527121040723982 0.90587073202438 0.999999999995441 GO:0051427 hormone receptor binding 2/2080 34/18639 0.0588235294117647 0.527121040723982 0.90587073202438 0.999999999995441 GO:0000339 RNA cap binding 1/2080 20/18639 0.05 0.448052884615385 0.906314268009292 0.999999999995441 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 1/2080 20/18639 0.05 0.448052884615385 0.906314268009292 0.999999999995441 GO:0005326 neurotransmitter transmembrane transporter activity 1/2080 20/18639 0.05 0.448052884615385 0.906314268009292 0.999999999995441 GO:0030627 pre-mRNA 5'-splice site binding 1/2080 20/18639 0.05 0.448052884615385 0.906314268009292 0.999999999995441 GO:0042288 MHC class I protein binding 1/2080 20/18639 0.05 0.448052884615385 0.906314268009292 0.999999999995441 GO:0004497 monooxygenase activity 8/2080 106/18639 0.0754716981132075 0.676306240928882 0.916269742675323 0.999999999995441 GO:0001846 opsonin binding 1/2080 21/18639 0.0476190476190476 0.426717032967033 0.916780260948798 0.999999999995441 GO:1904047 S-adenosyl-L-methionine binding 1/2080 21/18639 0.0476190476190476 0.426717032967033 0.916780260948798 0.999999999995441 GO:0004527 exonuclease activity 6/2080 84/18639 0.0714285714285714 0.640075549450549 0.918417499888784 0.999999999995441 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 2/2080 36/18639 0.0555555555555556 0.497836538461538 0.922193197268806 0.999999999995441 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 2/2080 36/18639 0.0555555555555556 0.497836538461538 0.922193197268806 0.999999999995441 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 2/2080 36/18639 0.0555555555555556 0.497836538461538 0.922193197268806 0.999999999995441 GO:0016798 hydrolase activity, acting on glycosyl bonds 10/2080 130/18639 0.0769230769230769 0.689312130177515 0.92552683626548 0.999999999995441 GO:0005244 voltage-gated monoatomic ion channel activity 14/2080 173/18639 0.0809248554913295 0.725172298799466 0.925878184822276 0.999999999995441 GO:0008649 rRNA methyltransferase activity 1/2080 22/18639 0.0454545454545455 0.407320804195804 0.926077556964831 0.999999999995441 GO:0033691 sialic acid binding 1/2080 22/18639 0.0454545454545455 0.407320804195804 0.926077556964831 0.999999999995441 GO:0034062 5'-3' RNA polymerase activity 1/2080 22/18639 0.0454545454545455 0.407320804195804 0.926077556964831 0.999999999995441 GO:0097747 RNA polymerase activity 1/2080 22/18639 0.0454545454545455 0.407320804195804 0.926077556964831 0.999999999995441 GO:0030594 neurotransmitter receptor activity 7/2080 97/18639 0.0721649484536082 0.646674266455194 0.926575491839774 0.999999999995441 GO:0050660 flavin adenine dinucleotide binding 6/2080 86/18639 0.0697674418604651 0.625190071556351 0.928500592207774 0.999999999995441 GO:0004620 phospholipase activity 8/2080 109/18639 0.073394495412844 0.657692307692308 0.929911583607424 0.999999999995441 GO:0005507 copper ion binding 4/2080 63/18639 0.0634920634920635 0.568956043956044 0.931775295088497 0.999999999995441 GO:0022832 voltage-gated channel activity 14/2080 175/18639 0.08 0.716884615384615 0.932712617930958 0.999999999995441 GO:0015276 ligand-gated monoatomic ion channel activity 15/2080 186/18639 0.0806451612903226 0.72266594292804 0.93394277632236 0.999999999995441 GO:0140102 catalytic activity, acting on a rRNA 1/2080 23/18639 0.0434782608695652 0.389611204013378 0.934336604153591 0.999999999995441 GO:0003743 translation initiation factor activity 3/2080 51/18639 0.0588235294117647 0.527121040723982 0.934354600056878 0.999999999995441 GO:0005501 retinoid binding 2/2080 38/18639 0.0526315789473684 0.471634615384615 0.935820096266675 0.999999999995441 GO:0019840 isoprenoid binding 2/2080 38/18639 0.0526315789473684 0.471634615384615 0.935820096266675 0.999999999995441 GO:0022834 ligand-gated channel activity 15/2080 188/18639 0.0797872340425532 0.714978007364976 0.939976150023377 0.999999999995441 GO:0015295 solute:proton symporter activity 1/2080 24/18639 0.0416666666666667 0.373377403846154 0.941673296426933 0.999999999995441 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 1/2080 24/18639 0.0416666666666667 0.373377403846154 0.941673296426933 0.999999999995441 GO:0030552 cAMP binding 1/2080 24/18639 0.0416666666666667 0.373377403846154 0.941673296426933 0.999999999995441 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 1/2080 24/18639 0.0416666666666667 0.373377403846154 0.941673296426933 0.999999999995441 GO:0140612 DNA damage sensor activity 1/2080 24/18639 0.0416666666666667 0.373377403846154 0.941673296426933 0.999999999995441 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 2/2080 39/18639 0.0512820512820513 0.459541420118343 0.941753159255053 0.999999999995441 GO:1901505 carbohydrate derivative transmembrane transporter activity 3/2080 53/18639 0.0566037735849057 0.507229680696662 0.944681672865912 0.999999999995441 GO:0071855 neuropeptide receptor binding 2/2080 40/18639 0.05 0.448052884615385 0.947162067858711 0.999999999995441 GO:0001848 complement binding 1/2080 25/18639 0.04 0.358442307692308 0.94819059663816 0.999999999995441 GO:0015645 fatty acid ligase activity 1/2080 25/18639 0.04 0.358442307692308 0.94819059663816 0.999999999995441 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 1/2080 25/18639 0.04 0.358442307692308 0.94819059663816 0.999999999995441 GO:0017056 structural constituent of nuclear pore 1/2080 25/18639 0.04 0.358442307692308 0.94819059663816 0.999999999995441 GO:0120515 fatty acid-CoA ligase activity 1/2080 25/18639 0.04 0.358442307692308 0.94819059663816 0.999999999995441 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 3/2080 54/18639 0.0555555555555556 0.497836538461538 0.949259213909112 0.999999999995441 GO:0046873 metal ion transmembrane transporter activity 40/2080 450/18639 0.0888888888888889 0.796538461538462 0.951447430729956 0.999999999995441 GO:0016877 ligase activity, forming carbon-sulfur bonds 2/2080 41/18639 0.0487804878048781 0.437124765478424 0.952089853005198 0.999999999995441 GO:0140223 general transcription initiation factor activity 4/2080 68/18639 0.0588235294117647 0.527121040723982 0.953893980978748 0.999999999995441 GO:0051139 metal cation:proton antiporter activity 1/2080 26/18639 0.0384615384615385 0.344656065088757 0.953979978769492 0.999999999995441 GO:0016859 cis-trans isomerase activity 2/2080 42/18639 0.0476190476190476 0.426717032967033 0.956576474463714 0.999999999995441 GO:0098960 postsynaptic neurotransmitter receptor activity 4/2080 69/18639 0.0579710144927536 0.519481605351171 0.957435091448701 0.999999999995441 GO:0004683 calcium/calmodulin-dependent protein kinase activity 1/2080 27/18639 0.037037037037037 0.331891025641026 0.959122709342718 0.999999999995441 GO:0022853 active monoatomic ion transmembrane transporter activity 8/2080 118/18639 0.0677966101694915 0.607529335071708 0.959887492702065 0.999999999995441 GO:0004601 peroxidase activity 3/2080 57/18639 0.0526315789473684 0.471634615384615 0.960958556696015 0.999999999995441 GO:0016298 lipase activity 9/2080 130/18639 0.0692307692307692 0.620380917159763 0.961084781991657 0.999999999995441 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 9/2080 130/18639 0.0692307692307692 0.620380917159763 0.961084781991657 0.999999999995441 GO:0016866 intramolecular transferase activity 1/2080 28/18639 0.0357142857142857 0.320037774725275 0.963690985968935 0.999999999995441 GO:0008408 3'-5' exonuclease activity 3/2080 58/18639 0.0517241379310345 0.463502984084881 0.964258647215547 0.999999999995441 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 3/2080 58/18639 0.0517241379310345 0.463502984084881 0.964258647215547 0.999999999995441 GO:0016790 thiolester hydrolase activity 2/2080 44/18639 0.0454545454545455 0.407320804195804 0.96437160984553 0.999999999995441 GO:0005179 hormone activity 9/2080 132/18639 0.0681818181818182 0.610981206293706 0.965617911366563 0.999999999995441 GO:0004540 RNA nuclease activity 8/2080 121/18639 0.0661157024793388 0.592466624284806 0.966949795159438 0.999999999995441 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 3/2080 59/18639 0.0508474576271186 0.455647001303781 0.96729453664964 0.999999999995441 GO:0016874 ligase activity 12/2080 167/18639 0.0718562874251497 0.64390833717181 0.967485786077915 0.999999999995441 GO:0008009 chemokine activity 2/2080 45/18639 0.0444444444444444 0.398269230769231 0.967746052261213 0.999999999995441 GO:0005125 cytokine activity 18/2080 234/18639 0.0769230769230769 0.689312130177515 0.969346972386276 0.999999999995441 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 3/2080 60/18639 0.05 0.448052884615385 0.970085668140319 0.999999999995441 GO:0048019 receptor antagonist activity 1/2080 30/18639 0.0333333333333333 0.298701923076923 0.9713535801328 0.999999999995441 GO:0015297 antiporter activity 9/2080 135/18639 0.0666666666666667 0.597403846153846 0.971528697275289 0.999999999995441 GO:0005310 dicarboxylic acid transmembrane transporter activity 1/2080 31/18639 0.032258064516129 0.289066377171216 0.974555501424851 0.999999999995441 GO:0038187 pattern recognition receptor activity 2/2080 48/18639 0.0416666666666667 0.373377403846154 0.976120860084018 0.999999999995441 GO:0022836 gated channel activity 25/2080 318/18639 0.0786163522012579 0.704485667634252 0.979874798406202 0.999999999995441 GO:0019239 deaminase activity 1/2080 33/18639 0.0303030303030303 0.271547202797203 0.979926080737749 0.999999999995441 GO:0015291 secondary active transmembrane transporter activity 22/2080 287/18639 0.0766550522648084 0.686910345751809 0.980935367827755 0.999999999995441 GO:0052689 carboxylic ester hydrolase activity 5/2080 92/18639 0.0543478260869565 0.487014005016722 0.981062142692363 0.999999999995441 GO:0015020 glucuronosyltransferase activity 1/2080 34/18639 0.0294117647058824 0.263560520361991 0.982170182213911 0.999999999995441 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 1/2080 34/18639 0.0294117647058824 0.263560520361991 0.982170182213911 0.999999999995441 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 1/2080 34/18639 0.0294117647058824 0.263560520361991 0.982170182213911 0.999999999995441 GO:0005216 monoatomic ion channel activity 37/2080 448/18639 0.0825892857142857 0.740087354052198 0.982959227114151 0.999999999995441 GO:0000175 3'-5'-RNA exonuclease activity 1/2080 35/18639 0.0285714285714286 0.25603021978022 0.984163518467341 0.999999999995441 GO:0004864 protein phosphatase inhibitor activity 2/2080 53/18639 0.0377358490566038 0.338153120464441 0.985624010608412 0.999999999995441 GO:0016251 RNA polymerase II general transcription initiation factor activity 2/2080 53/18639 0.0377358490566038 0.338153120464441 0.985624010608412 0.999999999995441 GO:0004869 cysteine-type endopeptidase inhibitor activity 1/2080 36/18639 0.0277777777777778 0.248918269230769 0.985934099073014 0.999999999995441 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 1/2080 36/18639 0.0277777777777778 0.248918269230769 0.985934099073014 0.999999999995441 GO:0055106 ubiquitin-protein transferase regulator activity 1/2080 36/18639 0.0277777777777778 0.248918269230769 0.985934099073014 0.999999999995441 GO:0030551 cyclic nucleotide binding 1/2080 37/18639 0.027027027027027 0.242190748440748 0.987506806374424 0.999999999995441 GO:0099094 ligand-gated monoatomic cation channel activity 8/2080 136/18639 0.0588235294117647 0.527121040723982 0.988072304147821 0.999999999995441 GO:0022804 active transmembrane transporter activity 37/2080 457/18639 0.0809628008752735 0.725512329574146 0.988154105674207 0.999999999995441 GO:0005261 monoatomic cation channel activity 26/2080 341/18639 0.0762463343108504 0.68324780058651 0.98859327364953 0.999999999995441 GO:0140299 molecular sensor activity 3/2080 71/18639 0.0422535211267606 0.378636240520043 0.989072255116993 0.999999999995441 GO:0019842 vitamin binding 9/2080 150/18639 0.06 0.537663461538461 0.989430186786494 0.999999999995441 GO:0019212 phosphatase inhibitor activity 2/2080 56/18639 0.0357142857142857 0.320037774725275 0.989433351217292 0.999999999995441 GO:0016209 antioxidant activity 4/2080 86/18639 0.0465116279069767 0.416793381037567 0.989758498316301 0.999999999995441 GO:0042379 chemokine receptor binding 3/2080 72/18639 0.0416666666666667 0.373377403846154 0.990049117510916 0.999999999995441 GO:0004521 RNA endonuclease activity 3/2080 73/18639 0.0410958904109589 0.368262644889357 0.990941491217766 0.999999999995441 GO:0016651 oxidoreductase activity, acting on NAD(P)H 4/2080 88/18639 0.0454545454545455 0.407320804195804 0.991400112177937 0.999999999995441 GO:0008137 NADH dehydrogenase (ubiquinone) activity 1/2080 41/18639 0.024390243902439 0.218562382739212 0.992225584551841 0.999999999995441 GO:0042287 MHC protein binding 1/2080 41/18639 0.024390243902439 0.218562382739212 0.992225584551841 0.999999999995441 GO:0004520 DNA endonuclease activity 1/2080 42/18639 0.0238095238095238 0.213358516483516 0.993095075041795 0.999999999995441 GO:0051536 iron-sulfur cluster binding 3/2080 76/18639 0.0394736842105263 0.353725961538462 0.993178849457837 0.999999999995441 GO:0051540 metal cluster binding 3/2080 77/18639 0.038961038961039 0.349132117882118 0.993797886991765 0.999999999995441 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1/2080 43/18639 0.0232558139534884 0.208396690518784 0.993867363255651 0.999999999995441 GO:0003954 NADH dehydrogenase activity 1/2080 44/18639 0.0227272727272727 0.203660402097902 0.994553311009374 0.999999999995441 GO:0051539 4 iron, 4 sulfur cluster binding 1/2080 45/18639 0.0222222222222222 0.199134615384615 0.995162566890014 0.999999999995441 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 1/2080 46/18639 0.0217391304347826 0.194805602006689 0.995703701711396 0.999999999995441 GO:0019843 rRNA binding 2/2080 65/18639 0.0307692307692308 0.275724852071006 0.995857489459574 0.999999999995441 GO:0008188 neuropeptide receptor activity 1/2080 48/18639 0.0208333333333333 0.186688701923077 0.996611211167039 0.999999999995441 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 2/2080 68/18639 0.0294117647058824 0.263560520361991 0.996979392578122 0.999999999995441 GO:0009055 electron transfer activity 5/2080 116/18639 0.0431034482758621 0.386252486737401 0.997426536412403 0.999999999995441 GO:0004518 nuclease activity 12/2080 209/18639 0.0574162679425837 0.514510489510489 0.997676730684419 0.999999999995441 GO:0004536 DNA nuclease activity 1/2080 64/18639 0.015625 0.140016526442308 0.99949275102483 0.999999999995441 GO:0008173 RNA methyltransferase activity 1/2080 67/18639 0.0149253731343284 0.133747129735936 0.99964479192919 0.999999999995441 GO:0015078 proton transmembrane transporter activity 8/2080 185/18639 0.0432432432432432 0.387505197505198 0.999729160227261 0.999999999995441 GO:0020037 heme binding 5/2080 142/18639 0.0352112676056338 0.315530200433369 0.99975032225362 0.999999999995441 GO:0004519 endonuclease activity 4/2080 127/18639 0.031496062992126 0.282238037552998 0.999768786110972 0.999999999995441 GO:0001653 peptide receptor activity 4/2080 128/18639 0.03125 0.280033052884615 0.999790135207146 0.999999999995441 GO:0003823 antigen binding 7/2080 174/18639 0.0402298850574713 0.360502320954907 0.999794156434669 0.999999999995441 GO:0046906 tetrapyrrole binding 5/2080 152/18639 0.0328947368421053 0.294771634615385 0.999901748867462 0.999999999995441 GO:0140098 catalytic activity, acting on RNA 21/2080 387/18639 0.0542635658914729 0.486258944543828 0.999974107789123 0.999999999995441 GO:0008528 G protein-coupled peptide receptor activity 2/2080 122/18639 0.0163934426229508 0.146902585119798 0.999991591220112 0.999999999995441 GO:0140101 catalytic activity, acting on a tRNA 1/2080 139/18639 0.00719424460431655 0.0644680409518539 0.999999932581557 0.999999999995441 GO:0030371 translation repressor activity 6/2080 329/18639 0.0182370820668693 0.163423544540566 0.999999999989597 0.999999999995441 GO:0045182 translation regulator activity 7/2080 356/18639 0.0196629213483146 0.176200572601556 0.999999999995441 0.999999999995441