category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	53/835	204/9376	2.91727133967359	CD44/HGF/ANK2/DDX5/STAT3/SDC2/WNT2/ACTG1/IQGAP1/WNT5A/PIK3R1/TWIST2/TGFB2/ARHGEF12/HIF1A/CTNNB1/COL1A2/CAV2/HCLS1/AKT3/PTPN11/TLR4/EIF4B/FRS2/PPP1CB/MAPK1/SOS1/MDM2/SOS2/FGFR1/ESR1/CAMK2D/RAF1/MMP2/THBS1/ANK1/CBL/MRAS/VAV3/PIK3CA/PPP1R12B/ITGA5/CAV1/SMAD2/WNT16/ITPR2/BRAF/FN1/PTK2/FGF2/MSN/FZD3/TWIST1	8.65647653160252
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	40/835	133/9376	3.37706541803611	STAT3/PRKAA2/GADD45G/INSR/SOD2/PIK3R1/TGFB2/MAPK10/SMAD3/GADD45B/SGK1/KLF2/FOXO1/EP300/IRS2/AKT3/SETD7/CCNG2/GADD45A/SGK3/MAPK1/SOS1/BCL6/MDM2/SOS2/SIRT1/RAF1/FOXO3/CREBBP/TGFBR1/PIK3CA/HOMER1/USP7/NLK/BRAF/CSNK1E/TGFBR2/HOMER2/RBL2/AGAP2	8.63246831298168
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	47/835	203/9376	2.59975811922952	LAMA3/LAMB1/HGF/COL6A1/LAMC1/JUN/ACTG1/VCL/PIK3R1/COL4A1/MAPK10/LAMA4/CTNNB1/ARHGAP5/PDGFRA/TNC/COL1A2/CAV2/AKT3/COL4A2/TNXB/PPP1CB/ITGB8/MAPK1/SOS1/FYN/SOS2/COL6A2/DOCK1/RAF1/THBS1/VAV3/VEGFC/PIK3CA/COL4A4/PPP1R12B/PAK2/ITGA5/CAV1/BRAF/FN1/TLN1/PDGFC/PTK2/CAPN2/MYLK/PAK3	7.20478723604942
NA	NA	hsa04517	IgSF CAM signaling	60/835	299/9376	2.25325936755252	TUBB2B/ANK2/NLGN1/APP/ROBO2/ACTR3B/EPB41L2/LRRC4C/PTPRD/ACTG1/VCL/IQGAP1/CADM1/AFDN/PIK3R1/NRCAM/LYN/MPDZ/MAPK10/CTNNB1/EPB41L3/SPTBN1/FOXO1/TUBB4A/ACTR2/AKT3/PTPN11/PRKCI/SLIT3/MYH10/MAPK1/FYN/NLGN4X/TUBB2A/FGFR1/KIRREL1/SPTAN1/NCAM1/SLITRK6/ACTR3/NCAM2/VAV3/PIK3CA/RAPGEF2/ROBO3/PAK2/ITGA5/TUBA1A/ABL1/PLXNA4/PTK2/RASA1/MYLK/ARPC5/MSN/PAK3/NCK2/CADM2/MYH9/PMP22	6.88620426333537
NA	NA	hsa04519	Cadherin signaling	73/835	404/9376	2.02895594948716	LHFPL6/VIM/CDH4/ACTR3B/WNT2/ACTG1/PCDH18/LEF1/VCL/WNT5A/AFDN/JUP/PCDH10/MPDZ/MAPK10/FAT1/CTNNB1/AXIN2/PDGFRA/TEAD1/EP300/CTNNA1/CDH11/ACTR2/ADAM10/DCHS2/TAOK1/PCDHB10/PCDH7/GABRE/PPP1CB/PKP2/MAPK1/ERBIN/NFKBIA/FGFR1/FMN1/ENAH/EVL/RAF1/PCDHB11/YWHAZ/ACTR3/CREBBP/PCDHGA5/STK3/LIMA1/MRAS/VAV3/PCDHB12/MOB1B/AMOTL2/PCDHB16/MYO1E/PCDHB9/PCDH9/WNT16/YAP1/RYK/GABRQ/NCKAP1/PTK2/ARPC5/CTNND1/MOB1A/LHFPL3/FZD3/PCDHB2/FAT4/AMOTL1/CSNK1A1/PCDHA9/APC	6.61024182501903
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	43/835	184/9376	2.62410830512887	EPHA7/EPHA5/CXCL12/EPHB1/ROBO2/LRRC4C/SEMA3E/BOC/WNT5A/PIK3R1/ARHGEF12/PPP3R1/NTNG1/PTPN11/SEMA3C/SLIT3/SEMA6A/PLXNC1/MAPK1/FYN/CAMK2D/TRPC4/ENAH/RAF1/SEMA6D/GNAI1/PIK3CA/ROBO3/PAK2/ABL1/BMPR2/PLXNA4/PPP3CB/RYK/PPP3R2/DPYSL2/PTK2/RASA1/PAK3/FZD3/EPHA3/NCK2/LIMK2	6.9565419094084
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	64/835	362/9376	1.98519204684554	HSP90AA1/LAMA3/LAMB1/HGF/COL6A1/LAMC1/MCL1/NR4A1/OSMR/NTF3/PRKAA2/INSR/PPP2R3A/PIK3R1/COL4A1/LAMA4/SGK1/FGF7/PDGFRA/TNC/COL1A2/AKT3/HSP90AB1/COL4A2/GNG12/TLR4/EIF4B/TNXB/LPAR2/SGK3/ITGB8/MAPK1/SOS1/MDM2/PKN2/IFNAR1/SOS2/FGFR1/COL6A2/PPP2CB/ATF2/NTRK1/RAF1/CREB1/YWHAZ/FOXO3/FGF18/THBS1/VEGFC/PIK3CA/COL4A4/ITGA5/FN1/PDGFC/PTK2/FGF2/PRLR/GNB1/GNG4/RBL2/TSC1/JAK1/CREB5/FGF10	5.97710548852221
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	29/835	110/9376	2.96030484485574	FBN1/ID4/GREM1/ZFYVE16/TGFB2/ID2/SMAD3/EP300/GREM2/FMOD/LEMD3/LTBP1/MAPK1/SMURF2/ZFYVE9/PPP2CB/TGIF1/THBS1/CREBBP/TGFBR1/SKIL/SMAD2/BMPR2/ACVR2B/TGFBR2/ACVR2A/NCOR1/HDAC2/SMAD7	6.46618793517446
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	25/835	87/9376	3.2266501479799	FOS/JUN/GADD45G/LEF1/PIK3R1/TGFB2/MAPK10/SMAD3/GADD45B/CTNNB1/AXIN2/AKT3/GADD45A/MAPK1/SOS1/PMAIP1/SOS2/RAF1/TGFBR1/PIK3CA/SMAD2/BRAF/TGFBR2/MSH2/APC	6.5238151322104
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	36/835	157/9376	2.57474350661734	HIPK3/GADD45G/HLA-C/PIK3R1/TGFB2/SMAD3/PPP3R1/GADD45B/ZFP36L1/HLA-E/FOXO1/SERPINE1/AKT3/GADD45A/ZFP36L2/HIPK2/PPP1CB/MAPK1/MDM2/SIRT1/RAF1/FOXO3/RBBP4/MRAS/TRPM7/TGFBR1/PIK3CA/TRAF3IP2/SMAD2/PPP3CB/ITPR2/PPP3R2/CAPN2/TGFBR2/RBL2/TSC1	6.22145923678598
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	49/835	250/9376	2.20083353293413	RAB31/NEDD4L/HSPA1A/ACTR3B/RAB11FIP1/PSD3/HLA-C/HSPA1B/SH3GLB1/ZFYVE16/PDCD6IP/SMAD3/HLA-E/PDGFRA/CAV2/ACTR2/ARFGEF1/WASHC4/NEDD4/PRKCI/IGF2R/CBLB/EPN2/MDM2/SMURF2/WASHC2C/ZFYVE9/ACTR3/WASHC2A/ARFGAP3/CBL/EPS15/TGFBR1/STAM2/CAV1/SMAD2/CLTC/RAB11FIP2/ACAP2/ITCH/RUFY2/ARPC5/RAB11FIP4/TGFBR2/SPART/AGAP2/VPS26A/EEA1/RAB11FIP3	6.01709812761789
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	55/835	300/9376	2.05860279441118	FOS/RPS6KA2/HGF/HSPA1A/JUND/MAP4K4/NR4A1/NTF3/JUN/GADD45G/INSR/MAP3K20/DUSP1/HSPA1B/STMN1/TGFB2/MAPK10/PPP3R1/GADD45B/FGF7/PDGFRA/MAP3K4/AKT3/TAOK1/NF1/GADD45A/GNG12/CACNA1B/MEF2C/MAPK1/SOS1/DUSP16/SOS2/FGFR1/ATF2/NTRK1/RAF1/FGF18/PPM1A/STK3/MRAS/TGFBR1/VEGFC/RAPGEF2/NLK/PAK2/PPP3CB/BRAF/PPP3R2/PDGFC/FGF2/RASA1/TGFBR2/MAP3K2/FGF10	5.8266768799615
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	46/835	232/9376	2.22638860210613	CXCL12/ACTR3B/ACTG1/VCL/IQGAP1/PIK3R1/ARHGEF12/FGF7/PDGFRA/ACTR2/AKT3/GNG12/LPAR2/MYH10/PPP1CB/ITGB8/MAPK1/SOS1/GSN/SOS2/FGFR1/DOCK1/ENAH/RAF1/ACTR3/FGF18/MRAS/VAV3/PIK3CA/PPP1R12B/PAK2/ITGA5/BRAF/FN1/PDGFC/NCKAP1/PTK2/FGF2/MYLK/ARPC5/MSN/PAK3/FGF10/MYH9/APC/LIMK2	5.91396165545032
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	58/835	333/9376	1.95575695455935	LAMA3/LAMB1/COL6A1/LAMC1/HLA-C/HEY2/WNT2/PPP2R3A/WNT5A/PIK3R1/COL4A1/NOTCH2/LAMA4/IRF1/HLA-E/CTNNB1/AXIN2/UBE3A/FOXO1/MAML3/EP300/TNC/COL1A2/AKT3/COL4A2/PRKCI/TNXB/ITGB8/MAPK1/SOS1/MDM2/IFNAR1/SOS2/COL6A2/PPP2CB/RAF1/CREB1/THBS1/CREBBP/PIK3CA/COL4A4/STAT2/ITGA5/WNT16/FN1/ATP6V1D/PTK2/FZD3/ATP6V1C1/MAML1/RBPJ/RBL2/CSNK1A1/TSC1/HDAC2/JAK1/CREB5/APC	5.55249061528149
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	26/835	101/9376	2.8905673800913	EGR1/STAT3/COL3A1/PIM1/JUN/PIK3R1/COL4A1/TGFB2/MAPK10/SMAD3/FOXO1/SERPINE1/COL1A2/AKT3/COL4A2/MAPK1/MMP2/PLCB1/TGFBR1/VEGFC/PIK3CA/COL4A4/SMAD2/FN1/AGT/TGFBR2	5.97269589800762
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	33/835	150/9376	2.47032335329341	HGF/GADD45G/WNT2/LEF1/WNT5A/PIK3R1/JUP/TGFB2/SMAD3/GADD45B/CTNNB1/FGF7/AXIN2/ABCB1/CTNNA1/AKT3/GADD45A/MAPK1/SOS1/SOS2/RAF1/FGF18/TGFBR1/PIK3CA/SMAD2/WNT16/BRAF/FGF2/TGFBR2/FZD3/CSNK1A1/FGF10/APC	5.67578942652602
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	30/835	130/9376	2.5912482726854	FOS/COL3A1/JUN/PIK3R1/COL4A1/MAPK10/COL1A2/AKT3/COL4A2/GNG12/MAPK1/SOS1/NFKBIA/SOS2/ATF2/RAF1/CREB1/MMP2/GNAI1/PLCB1/TGFBR1/VEGFC/PIK3CA/COL4A4/SMAD2/TGFBR2/EDNRB/GNB1/GNG4/CREB5	5.71224980932362
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	32/835	144/9376	2.49527611443779	STAT3/ID4/TBX3/WNT2/WNT5A/IL6ST/PIK3R1/KLF4/ID2/SMAD3/CTNNB1/AXIN2/RIF1/AKT3/MAPK1/FGFR1/BMI1/RAF1/PCGF5/KAT6A/PIK3CA/SKIL/SMAD2/WNT16/BMPR2/REST/ACVR2B/FGF2/FZD3/ACVR2A/JAK1/APC	5.65365442527579
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	44/835	233/9376	2.12044923029478	ANK2/VIM/COL6A1/SUN1/FBN1/COL3A1/SDC2/VCAN/COL5A2/ACTG1/TPM4/VCL/COL4A1/JUP/SPTBN1/FMNL2/SGCE/COL1A2/SYNE2/COL4A2/MYH10/ITGB8/PKP2/COL27A1/SYNE1/SPTAN1/COL6A2/TMOD3/LBR/NID1/SYNPO2/THBS1/LMOD1/DMD/COL4A4/FHL3/ITGA5/TMOD2/COL11A1/FN1/TLN1/SGCB/NEB/MYH9	5.41502290812653
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	20/835	69/9376	3.25470797535364	FOS/SLC18A2/FOSB/JUN/GRIN3A/PPP3R1/PPP1CB/CAMK2D/SIRT1/ATF2/CREB1/GRIA1/GRIA2/MAOB/PPP3CB/PPP3R2/GRIN2C/MAOA/HDAC2/CREB5	5.87738992875174
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	32/835	148/9376	2.42783621945299	FOS/PGR/JUN/GADD45G/HEY2/WNT2/LEF1/WNT5A/PIK3R1/NOTCH2/GADD45B/CTNNB1/FGF7/AXIN2/NCOA1/AKT3/GADD45A/MAPK1/SOS1/SOS2/FGFR1/ESR1/RAF1/FGF18/PIK3CA/WNT16/BRAF/FGF2/FZD3/CSNK1A1/FGF10/APC	5.47431740030661
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	35/835	170/9376	2.31179992955266	HGF/GADD45G/WNT2/ACTG1/LEF1/WNT5A/PIK3R1/TGFB2/SMAD3/NFE2L2/GADD45B/CTNNB1/AXIN2/GSTA1/TXNRD1/AKT3/GADD45A/MAPK1/SOS1/ARID2/SOS2/RAF1/GSTA4/ARID1B/SMARCC2/TGFBR1/PIK3CA/SMAD2/WNT16/BRAF/TGFBR2/FZD3/CSNK1A1/PBRM1/APC	5.39673500704002
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	21/835	77/9376	3.06238432226456	GADD45G/PIK3R1/TGFB2/SMAD3/GADD45B/AKT3/PTPN11/GADD45A/MAPK1/SOS1/MDM2/NFKBIA/SOS2/RAF1/CBL/TGFBR1/PIK3CA/ABL1/BRAF/TGFBR2/HDAC2	5.68160912370111
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	21/835	78/9376	3.02312298479963	ACTR3B/ACTG1/VCL/PIK3R1/CTNNB1/CTNNA1/CAV2/ACTR2/HCLS1/ARHGEF26/DOCK1/ACTR3/CBL/PIK3CA/ITGA5/CAV1/ARHGAP10/CLTC/FN1/PTK2/ARPC5	5.60982520730513
NA	NA	hsa04518	Integrin signaling	32/835	154/9376	2.33324519791586	LAMA3/LAMB1/HGF/C3/COL6A1/LAMC1/FBN1/ACTG1/VCL/PIK3R1/COL4A1/LAMA4/CTNNB1/PDGFRA/TNC/COL1A2/AKT3/COL4A2/TNXB/ITGB8/COL6A2/THBS1/VEGFC/PIK3CA/COL4A4/ITGA5/FN1/TLN1/PDGFC/PTK2/NCK2/FERMT2	5.21593708902805
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	19/835	70/9376	3.04780153977759	HGF/JUN/PIK3R1/TGFB2/HIF1A/EP300/AKT3/PTPN11/EPAS1/MAPK1/SOS1/SOS2/RAF1/CREBBP/PIK3CA/PAK2/BRAF/PAK3/CUL2	5.37687420624866
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	37/835	196/9376	2.11971159721374	ZFP36/FOS/C3/STAT3/JUN/HLA-C/LEF1/IL6ST/PIK3R1/LYN/HIF1A/MAPK10/PPP3R1/HLA-E/CTNNB1/EP300/AKT3/GNG12/CXCL2/MAPK1/IFNAR1/NFKBIA/RAF1/CREB1/CREBBP/MAP1LC3B/PIK3CA/STAT2/MICA/PPP3CB/ITPR2/PPP3R2/FGF2/GNB1/GNG4/PIK3C3/JAK1	4.9532173609006
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	17/835	59/9376	3.23540038566934	GADD45G/LEF1/PIK3R1/GADD45B/CTNNB1/AXIN2/CTNNA1/AKT3/GADD45A/MAPK1/SOS1/SOS2/RAF1/FOXO3/PIK3CA/BRAF/APC	5.38539787459057
Human Diseases	Cancer: specific types	hsa05218	Melanoma	19/835	73/9376	2.92254942170454	HGF/MITF/GADD45G/PIK3R1/GADD45B/FGF7/PDGFRA/AKT3/GADD45A/MAPK1/MDM2/FGFR1/RAF1/FGF18/PIK3CA/BRAF/PDGFC/FGF2/FGF10	5.15586986703978
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	43/835	248/9376	1.94691906509562	FOS/HSP90AA1/RHOB/TUBB2B/ACTR3B/JUN/ACTG1/LEF1/DYNC1H1/VPS41/MAPK10/AHNAK2/CTNNB1/TUBB4A/ACTR2/AKT3/HSP90AB1/CASP7/ARHGEF26/TLR4/EXOC5/MAPK1/NFKBIA/TUBB2A/ABI1/PIK3C2A/KPNA4/RAF1/ACTR3/SNX18/AHNAK/EXOC4/PIK3CA/FYCO1/TUBA1A/ANXA2/ACBD3/NCKAP1/ARPC5/PAK3/ARL8B/PIK3C3/DYNC1I2	4.72525663242104
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	24/835	106/9376	2.54235679584228	HSP90AA1/LEF1/PIK3R1/AR/CTNNB1/FOXO1/PDGFRA/EP300/AKT3/HSP90AB1/MAPK1/SOS1/MDM2/NFKBIA/SOS2/FGFR1/RAF1/CREB1/CREBBP/PIK3CA/BRAF/PDGFC/CREB5/KLK3	4.99312492450909
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	25/835	119/9376	2.35897951995169	FOS/JUNB/SOCS3/JUN/PIK3R1/CEBPB/MAPK10/IRF1/MMP14/AKT3/TNFAIP3/CASP7/CXCL2/MAPK1/NFKBIA/ATF2/CREB1/ADAM17/IL15/VEGFC/PIK3CA/RHBDF2/BCL3/ITCH/CREB5	4.66472209888034
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	28/835	142/9376	2.21411824238846	FOS/JUNB/FOSB/JUND/MITF/SOCS3/JUN/PIK3R1/FOSL2/TGFB2/MAPK10/PPP3R1/AKT3/PPARG/MAPK1/FYN/IFNAR1/NFKBIA/CREB1/ATP2A2/TGFBR1/PIK3CA/STAT2/PPP3CB/ITPR2/PPP3R2/TGFBR2/JAK1	4.55810931678976
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	30/835	157/9376	2.14561958884778	WNT2/ACTG1/LEF1/WNT5A/TGFB2/ID2/SMAD3/CTNNB1/AXIN2/TEAD1/CTNNA1/SERPINE1/PRKCI/TP53BP2/PPP1CB/PPP2CB/YWHAZ/STK3/TGFBR1/MOB1B/SMAD2/WNT16/BMPR2/YAP1/CSNK1E/MOB1A/TGFBR2/FZD3/SMAD7/APC	4.52608665660747
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	21/835	93/9376	2.53552250338034	INSR/ACTG1/LEF1/VCL/IQGAP1/AFDN/SMAD3/CTNNB1/EP300/CTNNA1/YES1/MAPK1/FER/FYN/SMURF2/FGFR1/CREBBP/TGFBR1/NLK/CTNND1/TGFBR2	4.65294586306029
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	17/835	67/9376	2.84908392170882	RPS6KA2/GNAQ/PPP3R1/EP300/PPP1CB/MAPK1/CAMK2D/RAF1/GRIA1/CREBBP/PLCB1/GRIA2/PPP3CB/ITPR2/BRAF/PPP3R2/GRIN2C	4.74916243014921
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	23/835	109/9376	2.36936768664506	FOS/HSP90AA1/STAT3/HLA-DQA2/JUN/RORA/IL6ST/GATA3/HIF1A/MAPK10/SMAD3/PPP3R1/HSP90AB1/HLA-DQA1/MAPK1/NFKBIA/HLA-DQB1/TGFBR1/SMAD2/PPP3CB/PPP3R2/TGFBR2/JAK1	4.49612376895437
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	18/835	77/9376	2.62490084765534	STAT3/GADD45G/PIK3R1/TGFB2/MAPK10/SMAD3/GADD45B/AKT3/GADD45A/MAPK1/RAF1/TGFBR1/PIK3CA/RALBP1/SMAD2/BRAF/TGFBR2/JAK1	4.47639723667563
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	29/835	157/9376	2.07409893588619	CEBPB/VPS41/HIF1A/ANO6/MEGF10/SGK1/ADAM10/CD24/PTPN11/CASP7/PPARG/MAPK1/ATP11B/DUSP16/CAMK2D/AXL/SIRT1/DOCK1/ATP8A2/CREB1/THBS1/ATP2A2/ADAM17/CD47/ABCA1/PTK2/PBX1/TMEM30A/MEGF11	4.24352455991105
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	17/835	71/9376	2.6885721514717	FOS/STAT3/SOCS3/PIK3R1/MAPK10/IRF1/AKT3/MAPK1/SOS1/SOS2/ESR1/RAF1/FOXO3/SOCS5/PIK3CA/SOCS4/PRLR	4.46544889152153
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	39/835	238/9376	1.84000402556232	HGF/NTF3/INSR/PLA2G2A/ETS2/AFDN/PIK3R1/MAPK10/FGF7/PDGFRA/AKT3/PTPN11/NF1/GNG12/RASA3/MAPK1/SOS1/SOS2/FGFR1/NTRK1/RAF1/FGF18/RALGAPA1/MRAS/VEGFC/PIK3CA/RALBP1/HTR7/PAK2/ABL1/RASAL2/PDGFC/FGF2/RASA1/PAK3/GNB1/GNG4/RGL1/FGF10	4.10410803083801
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	24/835	122/9376	2.2089329537646	DIO2/ACTG1/PIK3R1/NOTCH2/HIF1A/CTNNB1/FOXO1/EP300/NCOA1/AKT3/MED13/MED24/MAPK1/MDM2/TBC1D4/ESR1/RAF1/ATP2A2/CREBBP/PLCB1/PIK3CA/MED13L/NCOR1/HDAC2	4.20234688619727
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	24/835	122/9376	2.2089329537646	FOS/JUNB/STAT3/SOCS3/GNAQ/PIK3R1/MAPK10/EP300/IRS2/AKT3/MAPK1/SOS1/SOS2/ATF2/RAF1/CREB1/GNAI1/CREBBP/PLCB1/PIK3CA/ITPR2/PTK2/MRAP2/CREB5	4.20234688619727
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	37/835	224/9376	1.85474764756202	ZFP36/FOS/EGR1/HLA-DQA2/JUN/HLA-C/ETS2/PIK3R1/TGFB2/MAPK10/SMAD3/PPP3R1/HLA-E/EP300/AKT3/CANX/HLA-DQA1/MAPK1/NFKBIA/HLA-DQB1/ATF2/CREB1/CREBBP/IL15/TGFBR1/PIK3CA/CDC16/SMAD2/PPP3CB/IL15RA/PPP3R2/TLN1/TGFBR2/POLB/NFYB/JAK1/CREB5	4.04835354486067
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	34/835	201/9376	1.89938928113921	DDX5/MITF/PROM1/GADD45G/JMJD1C/RUNX1T1/JUP/CEBPB/ID2/WT1/GADD45B/AFF1/HPGD/FOXO1/NFKBIZ/KMT2A/GADD45A/KLF3/HOXA11/PPARG/MEF2C/BCL6/MDM2/BMI1/NTRK1/HOXA10/WNT16/PTK2/TGFBR2/PBX1/CEBPA/NCOR1/HDAC2/ZBTB16	4.03011291804779
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	23/835	116/9376	2.22638860210613	SLC38A2/GNAQ/GRIK2/GRIN3A/GRM8/PPP3R1/GNG12/MAPK1/GNAI1/GRIA1/GLUL/PLCB1/GRIA2/HOMER1/PPP3CB/ITPR2/SLC1A2/PPP3R2/GLS/GNB1/HOMER2/GNG4/GRIN2C	4.1555271286236
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	31/835	178/9376	1.95556751665209	WIF1/JUN/WNT2/LEF1/WNT5A/DKK2/MAPK10/SMAD3/PPP3R1/CTNNB1/AXIN2/DKK1/EP300/SERPINF1/TLE3/CAMK2D/SIRT1/CREBBP/TBL1XR1/PLCB1/NLK/WNT16/PPP3CB/RYK/GPC4/PPP3R2/CSNK1E/FZD3/CSNK1A1/ROR1/APC	4.02438194176698
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	21/835	103/9376	2.28935527004244	FOS/C3/JUN/GNAQ/GNA14/PIK3R1/TGFB2/MAPK10/GNAL/SERPINE1/AKT3/TLR4/MAPK1/NFKBIA/PPP2CB/GNAI1/PLCB1/TGFBR1/PIK3CA/SMAD2/TGFBR2	4.11391768020781
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	21/835	103/9376	2.28935527004244	LAMA3/LAMB1/LAMC1/COL3A1/GNAQ/VCL/GNA14/PIK3R1/COL4A1/TGFB2/LAMA4/GNAL/COL1A2/COL4A2/TLR4/CXCL2/PLCB1/PIK3CA/COL4A4/FN1/PTK2	4.11391768020781
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	35/835	212/9376	1.85380183030166	HGF/INSR/GNAQ/DOCK4/ACTG1/AFDN/PIK3R1/CTNNB1/FGF7/PDGFRA/AKT3/PRKCI/LPAR2/MAPK1/SIPA1L1/FGFR1/ENAH/EVL/RAF1/GNAI1/FGF18/THBS1/PLCB1/MRAS/VAV3/VEGFC/PIK3CA/RAPGEF2/BRAF/TLN1/PDGFC/FGF2/CTNND1/PRKD3/FGF10	3.93148829210236
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	25/835	133/9376	2.11066588627257	FOS/SLC18A2/GNAQ/PPP2R3A/MAPK10/GNAL/AKT3/GNG12/CACNA1B/PPP1CB/CAMK2D/PPP2CB/ATF2/CREB1/GNAI1/GRIA1/PLCB1/GRIA2/MAOB/PPP3CB/ITPR2/GNB1/GNG4/MAOA/CREB5	4.03345570416776
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	11/835	37/9376	3.33827480174786	GADD45G/LEF1/GADD45B/CTNNB1/GADD45A/PPARG/MAPK1/NTRK1/BRAF/TPR/NCOA4	4.45574921116954
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	15/835	62/9376	2.71663125362179	HEY2/DTX4/NOTCH2/MAML3/EP300/TLE3/ATXN1/CREBBP/ADAM17/SPEN/DTX3L/ITCH/MAML1/RBPJ/HDAC2	4.24013084085353
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	26/835	142/9376	2.05596693936072	FOS/HSP90AA1/SDC2/JUN/PRKAA2/ACTG1/DUSP1/PIK3R1/MAPK10/NFE2L2/CTNNB1/GSTA1/KLF2/CAV2/AKT3/HSP90AB1/MEF2C/MEF2A/GSTA4/MMP2/PIK3CA/CAV1/BMPR2/ACVR2B/PTK2/ACVR2A	3.96436901817182
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	29/835	168/9376	1.93829483889364	STAT3/MCL1/OSMR/PIM1/SOCS3/IL6ST/PIK3R1/PDGFRA/EP300/AKT3/PTPN11/IL13RA1/SOS1/IFNAR1/SOS2/RAF1/CREBBP/SOCS5/IL15/PIK3CA/STAT2/STAM2/IL15RA/AOX1/SOCS4/PIAS2/PRLR/JAK1/CLCF1	3.83694724514265
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	23/835	122/9376	2.11689408069108	FOS/JUN/PPP2R3A/PIK3R1/MAPK10/PPP3R1/AKT3/PTPN11/CBLB/MAPK1/SOS1/FYN/NFKBIA/SOS2/PPP2CB/RAF1/VAV3/PIK3CA/PAK2/PPP3CB/PPP3R2/PAK3/NCK2	3.88241245934158
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	29/835	169/9376	1.9268256386635	PRKAA2/RB1CC1/SH3GLB1/PIK3R1/VPS41/HIF1A/MAPK10/IRS2/DEPTOR/LAMP2/CALCOCO2/AKT3/TAX1BP1/CTSB/VMP1/OPTN/TANK/MAPK1/PPP2CB/RAF1/MAP1LC3B/MRAS/PIK3CA/BIRC6/WDFY3/C9orf72/NBR1/PIK3C3/TSC1	3.80151610637558
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	18/835	86/9376	2.35020192173792	JUN/PIK3R1/MAPK10/AKT3/CBLB/MAPK1/SOS1/SOS2/CAMK2D/RAF1/CBL/PIK3CA/PAK2/ABL1/BRAF/PTK2/PAK3/NCK2	3.93291540824718
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	25/835	139/9376	2.01955800628958	FOS/HSP90AA1/HSPA1A/PGR/JUN/GNAQ/HSPA1B/PIK3R1/NCOA1/AKT3/HSP90AB1/MAPK1/SOS1/SOS2/ESR1/ATF2/RAF1/CREB1/MMP2/GNAI1/PLCB1/PIK3CA/ITPR2/GREB1/CREB5	3.78641648884825
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	28/835	163/9376	1.92886374490283	FOS/STAT3/JUN/DDX3X/PIK3R1/TGFB2/MAPK10/SMAD3/EP300/AKT3/TLR4/MAPK1/SOS1/IFNAR1/NFKBIA/SOS2/ATF2/RAF1/CREB1/YWHAZ/CREBBP/TGFBR1/PIK3CA/STAT2/BRAF/TGFBR2/JAK1/CREB5	3.74041503139215
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	21/835	109/9376	2.16333571389331	RPS6KA2/STAT3/SOCS3/PRKAA2/INSR/SLC27A6/PIK3R1/MAPK10/FOXO1/IRS2/AKT3/PTPN11/OGT/PPP1CB/NFKBIA/TBC1D4/CREB1/PIK3CA/SREBF1/AGT/CREB5	3.81964713021959
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	17/835	80/9376	2.38610778443114	HGF/STAT3/PIK3R1/PDGFRA/AKT3/NF1/MAPK1/SOS1/SOS2/AXL/RAF1/FOXO3/PIK3CA/BRAF/PDGFC/FGF2/JAK1	3.89285702567318
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	20/835	103/9376	2.18033835242137	COL6A1/COL3A1/SLC38A2/COL5A2/COL21A1/COL14A1/COL28A1/MME/COL4A1/COL7A1/COL1A2/COL4A2/COL23A1/COL27A1/COL6A2/COL18A1/COL4A4/COL16A1/SLC3A2/COL11A1	3.76607978380839
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	27/835	158/9376	1.91883574622906	RPS6KA2/PRKAA2/INSR/WNT2/WNT5A/PIK3R1/SGK1/CLIP1/DEPTOR/AKT3/FNIP1/EIF4B/MAPK1/SOS1/SOS2/FNIP2/RAF1/PRR5L/CAB39/PIK3CA/WNT16/BRAF/SLC3A2/ATP6V1D/FZD3/ATP6V1C1/TSC1	3.64185448628139
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	34/835	216/9376	1.76748724772677	FOS/HSP90AA1/STAT3/HSPA1A/JUN/HSPA2/SOD2/HSPA1B/PIK3R1/LYN/MAPK10/PPP3R1/NFE2L2/AKT3/MIB1/HSP90AB1/CASP7/TLR4/CXCL2/TANK/PPARG/MAPK1/HSPD1/NFKBIA/CAMK2D/HSPA4/PLCB1/VAV3/PIK3CA/PPP3CB/PPP3R2/ABCA1/PTK2/ERO1A	3.56799980434286
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	18/835	89/9376	2.27098163224114	LAMA3/CD44/LAMB1/COL6A1/LAMC1/COL4A1/LAMA4/TNC/COL1A2/COL4A2/TNXB/ITGB8/COL6A2/THBS1/COL4A4/ITGA5/FN1/CD47	3.76678706059588
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	15/835	68/9376	2.47692849594928	STAT3/PIM1/LEF1/RUNX1T1/PIK3R1/JUP/AKT3/MAPK1/SOS1/SOS2/RAF1/PIK3CA/BRAF/CEBPA/ZBTB16	3.82173222144153
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	20/835	105/9376	2.13880809808953	JUN/PIK3R1/ARHGEF12/MAPK10/PPP3R1/IRF1/AKT3/PTPN11/CBLB/MAPK1/MDM2/NFKBIA/RAF1/MRAS/PIK3CA/STAT2/PPP3CB/ITPR2/BCL3/PPP3R2	3.66907357608591
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	14/835	62/9376	2.53552250338034	HSPA1A/PRKAA2/INSR/SOD2/HSPA1B/PIK3R1/FOXO1/IRS2/AKT3/SIRT1/FOXO3/PIK3CA/EIF4EBP2/HDAC2	3.79278677914719
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	12/835	49/9376	2.74989612611512	SLC18A2/FOSB/JUN/GRIN3A/ATF2/CREB1/GNAI1/GRIA2/MAOB/GRIN2C/MAOA/CREB5	3.83984625958463
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	14/835	63/9376	2.49527611443779	PRDM2/SETD2/KMT2A/SETD7/ALDH3A2/ASH1L/PHYKPL/PRDM6/NSD1/EHMT1/KMT5B/SMYD3/AASS/KMT2C	3.72324302168134
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	21/835	115/9376	2.05046602447279	FOS/EGR1/JUND/GNAQ/AKAP13/GATA3/SGK1/MMP14/MEF2C/MAPK1/FGFR1/MEF2A/ATF2/RAF1/CREB1/GNAI1/PLCB1/ITPR2/BRAF/MMP16/CREB5	3.54385956562062
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	31/835	200/9376	1.74045508982036	FOS/TUBB2B/ACTR3B/JUN/ACTG1/ARHGEF12/MAPK10/TUBB4A/NCL/ACTR2/HCLS1/PTPN11/CASP7/TLR4/LPAR2/MYH10/MAPK1/FYN/NFKBIA/TUBB2A/ABI1/ACTR3/PAK2/MYO1E/TUBA1A/ABL1/NCKAP1/ARPC5/PAK3/NCK2/MYH9	3.30949350543529
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	34/835	227/9376	1.68183808594265	CXCL12/STAT3/HLA-C/GNAQ/AKAP13/PIK3R1/ARHGEF12/PPP3R1/HLA-E/CTNNB1/PDGFRA/AKT3/GNG12/MAPK1/SOS1/MDM2/NFKBIA/SOS2/PTGER3/ATF2/RAF1/CREB1/GNAI1/PLCB1/PIK3CA/PPP3CB/ITPR2/PPP3R2/PTK2/GNB1/GNG4/TSC1/JAK1/CREB5	3.25148598274611
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	17/835	90/9376	2.12098469727212	PRKAA2/INSR/RB1CC1/SOD2/PIK3R1/FOXO1/IRS2/AKT3/PPARG/SIRT1/ATF2/CREB1/FOXO3/PIK3CA/EHMT1/TSC1/CREB5	3.3410356834322
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	23/835	138/9376	1.87145708582834	SOCS3/PRKAA2/INSR/PIK3R1/MAPK10/FOXO1/IRS2/AKT3/PRKCI/CBLB/PPP1CB/MAPK1/SOS1/SOS2/RAF1/CBL/PIK3CA/RHOQ/SREBF1/BRAF/SOCS4/TSC1/HK1	3.22456462129675
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	23/835	138/9376	1.87145708582834	FOS/RPS6KA2/ACTR3B/JUN/GNAQ/ACTG1/PIK3R1/ARHGEF12/MAPK10/ACTR2/AKT3/TLR4/MAPK1/PKN2/NFKBIA/DOCK1/ACTR3/VAV3/PIK3CA/ITGA5/FN1/PTK2/ARPC5	3.22456462129675
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	25/835	155/9376	1.81108750241453	TUBB2B/C3/HLA-DQA2/PLA2R1/HLA-C/ACTG1/DYNC1H1/HLA-E/TUBB4A/LAMP2/TLR4/CANX/HLA-DQA1/HLA-DQB1/TUBB2A/THBS1/STX12/ITGA5/TUBA1A/ATP6V1D/ATP6V1C1/C1R/PIK3C3/EEA1/DYNC1I2	3.18360415426467
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	20/835	115/9376	1.95282478521218	SLC18A2/APP/GNAQ/DUSP1/HTR2A/GNG12/CACNA1B/MAPK1/KCND2/RAF1/GNAI1/PLCB1/MAOB/HTR7/CYP4X1/ITPR2/BRAF/GNB1/GNG4/MAOA	3.21445639436963
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	23/835	140/9376	1.84472198460222	EGR1/PRKAA2/GNAQ/SMAD3/KLF2/SERPINE1/AKT3/GNG12/MEF2C/MAPK1/MEF2A/RAF1/GNAI1/MAP1LC3B/PLCB1/MRAS/TGFBR1/SMAD2/ITPR2/MYLK/GNB1/GNG4/PIK3C3	3.14854835794991
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	32/835	217/9376	1.655851430779	FOS/HSP90AA1/RPS6KA2/STAT3/PGR/JUN/PIK3R1/KLF4/NOTCH2/AR/FGF7/GSTA1/AKT3/HSP90AB1/CACNA1B/MAPK1/SOS1/BCL6/SOS2/ESR1/KPNA4/ATF2/RAF1/CREB1/GSTA4/GNAI1/FGF18/PIK3CA/EPHX1/FGF2/CREB5/FGF10	3.05622851017704
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	8/835	29/9376	3.09758414206071	TEAD1/DCHS2/STK3/MOB1B/YAP1/CSNK1E/MOB1A/FAT4	3.53717692873484
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	17/835	93/9376	2.0525658360698	FOS/HLA-DQA2/JUN/GATA3/NOTCH2/MAPK10/PPP3R1/MAML3/HLA-DQA1/MAPK1/NFKBIA/HLA-DQB1/PPP3CB/PPP3R2/MAML1/RBPJ/JAK1	3.18948881684118
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	23/835	142/9376	1.81873998481909	NEDD4L/SOCS3/TRIP12/CUL4B/UBR5/UBE3A/CUL3/HUWE1/UBE2H/NEDD4/KLHL9/CBLB/UBE2B/MDM2/SMURF2/HERC4/CBL/CDC16/BIRC6/ITCH/PIAS2/UBA6/CUL2	3.07375857024491
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	20/835	120/9376	1.87145708582834	RPS6KA2/NTF3/JUN/KIDINS220/PIK3R1/MAPK10/AKT3/PTPN11/FRS2/MAPK1/SOS1/NFKBIA/SOS2/CAMK2D/NTRK1/RAF1/FOXO3/PIK3CA/ABL1/BRAF	3.00399683365054
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	14/835	73/9376	2.15345746862439	HGF/STAT3/GADD45G/PIK3R1/GADD45B/AKT3/GADD45A/MAPK1/SOS1/SOS2/RAF1/FOXO3/PIK3CA/BRAF	3.09332833697446
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	22/835	137/9376	1.80315573233096	FOS/MCL1/JUN/GADD45G/ACTG1/PIK3R1/MAPK10/GADD45B/AKT3/CASP7/GADD45A/CTSB/MAPK1/PMAIP1/NFKBIA/SPTAN1/NTRK1/RAF1/PIK3CA/TUBA1A/ITPR2/CAPN2	2.96088867186136
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	16/835	89/9376	2.0186503397699	TUBB2B/GNAQ/PDGFRA/TUBB4A/HTR2A/MAPK1/SOS1/TUBB2A/SOS2/RAF1/GNAI1/PLCB1/TUBA1A/ITPR2/PDGFC/MAP3K2	3.01895701856128
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	27/835	181/9376	1.67500578952592	C3/HLA-DQA2/PLA2R1/CEBPB/TGFB2/ARHGEF12/MAPK10/PPP3R1/EP300/LAMP2/AKT3/CEBPG/TLR4/HLA-DQA1/MAPK1/HSPD1/HLA-DQB1/CAMK2D/RAF1/CREB1/CREBBP/PPP3CB/PPP3R2/NFYB/PIK3C3/JAK1/EEA1	2.86711711651281
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	15/835	82/9376	2.05403826493355	HSP90AA1/HSPA1A/HLA-DQA2/HSPA2/HLA-C/HSPA1B/HLA-E/HSP90AB1/CTSB/CANX/HLA-DQA1/HLA-DQB1/HSPA4/CREB1/NFYB	2.99734327894936
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	16/835	90/9376	1.99622089155023	FOS/STAT3/JUN/PIK3R1/HIF1A/PPP3R1/AKT3/PTPN11/TLR4/MAPK1/NFKBIA/RAF1/PIK3CA/PPP3CB/PPP3R2/JAK1	2.96918375009894
Organismal Systems	Nervous system	hsa04730	Long-term depression	12/835	60/9376	2.24574850299401	GNAQ/LYN/MAPK1/PPP2CB/RAF1/GRID2/GNAI1/GRIA1/PLCB1/GRIA2/ITPR2/BRAF	3.02667489322933
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	15/835	83/9376	2.02929081595844	EP300/L3MBTL3/OGT/PHC2/BMI1/PHC3/PCGF5/CREBBP/RBBP4/USP7/LCOR/MBD5/MGA/FOXK2/HDAC2	2.94492128058129
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	16/835	91/9376	1.97428439823649	FOS/JUN/IFITM1/PIK3R1/LYN/PPP3R1/AKT3/MAPK1/SOS1/NFKBIA/SOS2/RAF1/VAV3/PIK3CA/PPP3CB/PPP3R2	2.92004809855432
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	17/835	99/9376	1.92816790661102	FOS/JUN/PIK3R1/NOTCH2/MAPK10/AKT3/MAPK1/SOS1/MDM2/SOS2/ESR1/RAF1/MMP2/PIK3CA/BRAF/PTK2/NCOR1	2.90278507667408
Human Diseases	Cancer: specific types	hsa05214	Glioma	14/835	76/9376	2.06845256854712	GADD45G/PIK3R1/GADD45B/PDGFRA/AKT3/GADD45A/MAPK1/SOS1/MDM2/SOS2/CAMK2D/RAF1/PIK3CA/BRAF	2.9241192801643
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	10/835	47/9376	2.38909415212129	SOCS3/INSR/PIK3R1/MAPK10/IRS2/CACNA1B/MAPK1/PIK3CA/SOCS4/HK1	2.98495357161499
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	17/835	101/9376	1.88998636390585	MITF/GNAQ/WNT2/LEF1/WNT5A/CTNNB1/EP300/MAPK1/CAMK2D/RAF1/CREB1/GNAI1/CREBBP/PLCB1/WNT16/FZD3/EDNRB	2.81165218492582
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	16/835	93/9376	1.93182666924216	LAMA3/LAMB1/LAMC1/GADD45G/PIK3R1/COL4A1/LAMA4/GADD45B/AKT3/COL4A2/GADD45A/NFKBIA/PIK3CA/COL4A4/FN1/PTK2	2.8236245552864
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	13/835	70/9376	2.0853378956373	HLA-DQA2/EIF4G2/HLA-C/ACTG1/HLA-E/SGCE/HLA-DQA1/FYN/HLA-DQB1/DMD/CAV1/ABL1/SGCB	2.84975141524222
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	14/835	78/9376	2.01541532319975	FOS/C3/SERPING1/C1S/JUN/MAPK10/IRF1/CASP7/TLR4/MAPK1/C2/GNAI1/ITGA5/C1R	2.81559871484236
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	25/835	170/9376	1.65128566396619	NEDD4L/ACTR3B/JUN/PRKAA2/ACTG1/CGNL1/AFDN/MPDZ/MAPK10/ACTR2/HCLS1/NEDD4/PRKCI/MYH10/HSPA4/PPP2CB/ACTR3/AMOTL2/RAPGEF2/TUBA1A/RAB8B/ARPC5/MSN/AMOTL1/MYH9	2.67938430482171
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	8/835	34/9376	2.6420570623459	PRKAA2/RORA/BHLHE40/NR1D2/CREB1/NFIL3/CSNK1E/FBXL3	2.99904019898969
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	18/835	112/9376	1.80461933276305	LAMA3/LAMB1/STAT3/HSPA1A/LAMC1/HLA-DQA2/HSPA1B/TGFB2/MAPK10/LAMA4/AKT3/TLR4/HLA-DQA1/MAPK1/NFKBIA/HLA-DQB1/GNAI1/JAK1	2.6783955601236
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	23/835	155/9376	1.66620050222136	NR4A1/PDE8B/GNAQ/WNT2/LEF1/WNT5A/CTNNB1/AXIN2/KMT2A/MAPK1/CAMK2D/ATF2/CREB1/GNAI1/PLCB1/WNT16/ITPR2/BRAF/AGT/FZD3/PBX1/CREB5/APC	2.61490736835592
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	31/835	227/9376	1.53344060777124	FOS/HGF/JUN/SOD2/PIK3R1/AKR1C3/MT-ATP6/MT-ND1/HIF1A/MAPK10/NFE2L2/MT-ND4/GSTA1/MT-ND2/AKR1C2/AKT3/PTPN11/MAPK1/SOS1/NFKBIA/SOS2/RAF1/GSTA4/FOXO3/PIK3CA/MT-ND4L/ABL1/EPHX1/BRAF/PTK2/PRKD3	2.54382190516363
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	17/835	107/9376	1.78400582013543	PRKAA2/GNAQ/PPP3R1/FOXO1/EP300/AKT3/CAMK2D/PPP4R3A/SIRT1/ATF2/CREB1/CREBBP/PLCB1/PPP3CB/ITPR2/PPP3R2/CREB5	2.55017068735421
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	5/835	17/9376	3.30257132793237	LAMP2/PCDH7/MYH10/PCDH9/MYH9	2.9709636930582
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	28/835	205/9376	1.53368190448372	C3/STAT3/JUN/HLA-C/DDX3X/IL6ST/PIK3R1/LYN/HLA-E/UBE3A/EP300/MAPK1/MDM2/PMAIP1/NFKBIA/GSN/ATF2/CREB1/YWHAZ/CREBBP/PIK3CA/USP7/POLB/RBPJ/RBL2/HDAC2/JAK1/CREB5	2.41560308885367
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	15/835	93/9376	1.81108750241453	EGR1/JUN/GNAQ/MAPK10/MMP14/MAP3K4/MAPK1/SOS1/SOS2/CAMK2D/RAF1/MMP2/PLCB1/ITPR2/MAP3K2	2.45776029373162
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	47/835	388/9376	1.36018272732885	TUBB2B/APP/INSR/RB1CC1/GNAQ/WNT2/WNT5A/PIK3R1/MME/MT-ATP6/MT-ND1/DKK2/MAPK10/PPP3R1/CTNNB1/AXIN2/MT-ND4/DKK1/MT-ND2/TUBB4A/IRS2/RTN4/ADAM10/AKT3/CASP7/MAPK1/TUBB2A/RAF1/BACE1/ATP2A2/ADAM17/PLCB1/PIK3CA/MT-ND4L/TUBA1A/WNT16/PPP3CB/ITPR2/BRAF/PPP3R2/CAPN2/CSNK1E/FZD3/GRIN2C/CSNK1A1/PIK3C3/APC	2.26559213412646
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	23/835	166/9376	1.55578962556814	INSR/GNAQ/GTF2I/PPP3R1/IRS2/AKT3/PPP1CB/MEF2C/MAPK1/RGS2/MEF2A/ATF2/RAF1/CREB1/GNAI1/ATP2A2/PLCB1/PPP3CB/ITPR2/PPP3R2/MYLK/EDNRB/CREB5	2.25896332391251
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	11/835	63/9376	1.96057408991541	GADD45G/WNT2/LEF1/WNT5A/GADD45B/CTNNB1/AXIN2/GADD45A/WNT16/FZD3/APC	2.39183301502155
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	18/835	122/9376	1.65669971532345	PRKAA2/INSR/PPP2R3A/PIK3R1/FOXO1/IRS2/AKT3/PPARG/PPP2CB/SIRT1/CREB1/FOXO3/TBC1D1/CAB39/PIK3CA/SREBF1/TSC1/CREB5	2.28274032506313
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	22/835	158/9376	1.56349579322368	GADD45G/ATRX/NIPBL/TGFB2/SMAD3/GADD45B/EP300/STAG2/SMC1A/GADD45A/RAD21/PDS5B/MDM2/PPP2CB/YWHAZ/CREBBP/CDC16/SMAD2/ABL1/RBL2/HDAC2/CDC7	2.23344563048895
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	27/835	205/9376	1.47890755075215	CD44/STAT3/VIM/HLA-DQA2/JUN/GADD45G/HLA-C/PIK3R1/LYN/MAPK10/GADD45B/HLA-E/AKT3/TNFAIP3/NEDD4/GADD45A/HLA-DQA1/MDM2/IFNAR1/NFKBIA/HLA-DQB1/PIK3CA/USP7/STAT2/RBPJ/HDAC2/JAK1	2.16767806656549
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	17/835	115/9376	1.65990106743036	FOS/GNAQ/PIK3R1/AKT3/GNG12/CACNA1B/MAPK1/FYN/CAMK2D/CREB1/GNAI1/PLCB1/PIK3CA/ITPR2/GNB1/GNG4/CREB5	2.22624688061665
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	15/835	98/9376	1.71868507882195	MARCKS/ACTR3B/PIK3R1/LYN/ACTR2/AKT3/MAPK1/GSN/DOCK1/RAF1/ACTR3/VAV3/PIK3CA/ARPC5/LIMK2	2.23614003431147
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	32/835	253/9376	1.42023620742704	CD44/C3/ACTR3B/JUN/ACTG1/VCL/FNBP1L/PIK3R1/MAPK10/FOXO1/ACTR2/HCLS1/CALCOCO2/AKT3/TLR4/MAPK1/MDM2/NFKBIA/DOCK1/ACTR3/FOXO3/MAP1LC3B/PLCB1/PIK3CA/ITGA5/ITPR2/TLN1/PTK2/CAPN2/ARPC5/PIK3C3/HK1	2.11865092270251
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	8/835	42/9376	2.13880809808953	SLC40A1/FTL/PCBP2/MAP1LC3B/SLC3A2/NCOA4/ACSL1/ACSL3	2.31268140614341
Organismal Systems	Immune system	hsa04611	Platelet activation	18/835	126/9376	1.60410607356715	COL3A1/GNAQ/ACTG1/PIK3R1/LYN/ARHGEF12/COL1A2/AKT3/PRKCI/PPP1CB/MAPK1/FYN/GNAI1/PLCB1/PIK3CA/ITPR2/TLN1/MYLK	2.1345293130774
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	20/835	144/9376	1.55954757152362	RORA/RB1CC1/GNAQ/GRIN3A/PIK3R1/MAPK10/AKT3/PUM1/ATXN1/GRIA1/ATP2A2/PLCB1/GRIA2/PIK3CA/ITPR2/PUM2/ATXN3/RBPJ/GRIN2C/PIK3C3	2.11565514445891
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	11/835	66/9376	1.87145708582834	STAT3/HLA-DQA2/JUN/RORA/GATA3/TGFB2/SMAD3/TLR4/HLA-DQA1/HLA-DQB1/SMAD2	2.2213533533765
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	5/835	21/9376	2.67351012261192	CHST7/CHST11/CSGALNACT1/CSGALNACT2/DSEL	2.40043864594507
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	14/835	94/9376	1.6723659064849	FOS/HSP90AA1/FOSB/IL17RB/JUND/JUN/CEBPB/MAPK10/HSP90AB1/TNFAIP3/CXCL2/MAPK1/NFKBIA/TRAF3IP2	2.0484404512814
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	27/835	214/9376	1.41671050422519	FOS/JUN/HLA-C/GNAQ/PIK3R1/CUL4B/MAPK10/PPP3R1/HLA-E/AKT3/GNG12/TLR4/MAPK1/NFKBIA/RAF1/GNAI1/PIK3CA/PAK2/PPP3CB/ITPR2/PPP3R2/PTK2/PAK3/GNB1/GNG4/SAMHD1/LIMK2	1.92806071603444
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	11/835	69/9376	1.7900893864445	PIK3R1/LYN/MAPK10/AKT3/MAPK1/SOS1/FYN/SOS2/RAF1/VAV3/PIK3CA	2.05954094874491
Organismal Systems	Endocrine system	hsa04924	Renin secretion	11/835	69/9376	1.7900893864445	GNAQ/PPP3R1/CLCA1/CTSB/CREB1/GNAI1/PLCB1/PPP3CB/ITPR2/PPP3R2/AGT	2.05954094874491
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	24/835	187/9376	1.44112203400685	HSP90AA1/JUN/IFI16/MAPK10/ANTXR2/HSP90AB1/TNFAIP3/CTSB/TLR4/CXCL2/NAMPT/TANK/MAPK1/ERBIN/PKN2/IFNAR1/NFKBIA/MAP1LC3B/PLCB1/TRPM7/STAT2/ITPR2/NLRP1/JAK1	1.90510950494428
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	31/835	254/9376	1.37043707859871	HGF/CD38/GNAQ/HRH1/GNA14/GRIN3A/PPP3R1/FGF7/GNAL/PDGFRA/HTR2A/CACNA1B/FGFR1/PTGER3/CAMK2D/NTRK1/FGF18/ATP2A2/PLCB1/VEGFC/HTR7/PPP3CB/ITPR2/PPP3R2/PDGFC/FGF2/MYLK/EDNRB/GRIN2C/MCOLN3/FGF10	1.8713748558016
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	11/835	70/9376	1.76451668092387	STAT3/SOCS3/PRKAA2/MAPK10/IRS2/AKT3/PTPN11/NPY/NFKBIA/ACSL1/ACSL3	2.00737715157341
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	15/835	105/9376	1.60410607356715	MITF/JUN/HIF1A/MAPK10/CITED2/HUWE1/CALCOCO2/TAX1BP1/BNIP3L/OPTN/SMURF2/FOXO3/MAP1LC3B/MRAS/NBR1	1.94634164913005
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	21/835	160/9376	1.47377245508982	NLGN1/CDH4/SDC2/HLA-DQA2/NRXN1/VCAN/LRRC4C/HLA-C/PTPRD/CADM1/NRCAM/HLA-E/NTNG1/ALCAM/HLA-DQA1/ITGB8/NLGN4X/HLA-DQB1/NCAM1/SLITRK6/NCAM2	1.8898750030242
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	13/835	88/9376	1.6587915078933	C3/SERPING1/C1S/SERPINE2/SERPINE1/A2M/CFD/CD46/MASP1/C2/CFI/TFPI/C1R	1.94134508264576
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	7/835	38/9376	2.06845256854712	NT5E/CD38/NNMT/NAMPT/SIRT1/AOX1/NMRK1	2.06345321244276
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	11/835	71/9376	1.73966433330522	PIK3R1/HIF1A/PDGFRA/AKT3/MAPK1/FGFR1/NTRK1/RAF1/PIK3CA/GLS/HK1	1.95605101883096
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	16/835	116/9376	1.54879207103035	CXCL12/ACTG1/VCL/AFDN/PIK3R1/CTNNB1/ARHGAP5/CTNNA1/PTPN11/MMP2/GNAI1/VAV3/PIK3CA/PTK2/CTNND1/MSN	1.85954136822841
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	20/835	154/9376	1.45827824869741	FOS/CD38/JUN/PRKAA2/GNAQ/ACTG1/PPP3R1/PPP1CB/MEF2C/MAPK1/RGS2/CAMK2D/RAF1/GNAI1/PLCB1/PPP1R12B/PPP3CB/ITPR2/PPP3R2/MYLK	1.79288139811961
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	14/835	99/9376	1.58790298191496	FOS/JUN/PIK3R1/HIF1A/MAPK10/PDGFRA/AKT3/MAPK1/SOS1/SOS2/RAF1/PIK3CA/PDGFC/TSC1	1.83862853938358
Human Diseases	Infectious disease: viral	hsa05162	Measles	18/835	136/9376	1.48615709756957	FOS/STAT3/HSPA1A/JUN/HSPA1B/PIK3R1/MAPK10/AKT3/TNFAIP3/TLR4/CBLB/CD46/IFNAR1/NFKBIA/PIK3CA/STAT2/MSN/JAK1	1.7856017961904
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	9/835	56/9376	1.80461933276305	C3/HSPA1A/HSPA1B/CLK1/CASP7/TLR4/CXCL2/HSPD1/NFKBIA	1.88821322711772
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	24/835	193/9376	1.39632031274239	CXCL12/STAT3/GNAQ/PIK3R1/LYN/AKT3/GNG12/CXCL2/MAPK1/SOS1/NFKBIA/SOS2/RAF1/FOXO3/GNAI1/PLCB1/VAV3/PIK3CA/STAT2/BRAF/CXCL13/PTK2/GNB1/GNG4	1.73943101415813
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	10/835	65/9376	1.72749884845693	NR4A1/PDE8B/GNAQ/ATF2/CREB1/PLCB1/ITPR2/AGT/PBX1/CREB5	1.84020132990249
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	10/835	65/9376	1.72749884845693	GNAQ/PIK3R1/AKT3/MAPK1/TRPC4/RAF1/PLCB1/PIK3CA/ITPR2/HCN1	1.84020132990249
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	15/835	110/9376	1.53119216113228	STAT3/INSR/PIK3R1/HIF1A/EP300/SERPINE1/AKT3/TLR4/EPAS1/MAPK1/CAMK2D/CREBBP/PIK3CA/CUL2/HK1	1.75217051194176
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	37/835	323/9376	1.28626462245787	CD44/MARCKS/STAT3/VIM/MCL1/PIM1/STMN1/PIK3R1/TGFB2/NOTCH2/PDGFRA/ZEB2/SOX4/ABCB1/EP300/TNC/IRS2/TNXB/MAPK1/SOS1/MDM2/SOS2/BMI1/SIRT1/RAF1/THBS1/CREBBP/PIK3CA/ITGA5/ABL1/BMPR2/ABCC1/FZD3/GLS/MMP16/HDAC2/APC	1.63699440762493
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	8/835	49/9376	1.83326408407674	ST6GAL2/ST6GAL1/C1GALT1/OGT/GALNT3/GALNT13/GALNTL6/GXYLT1	1.82845480296687
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	11/835	75/9376	1.64688223552894	REV3L/PIK3R1/TOP2B/GSTA1/AKT3/MAPK1/MDM2/PMAIP1/GSTA4/PIK3CA/MSH2	1.75859384723846
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	7/835	41/9376	1.91710238060464	GRIN3A/CACNA1B/GABRE/GRIA1/GRIA2/GABRQ/GRIN2C	1.84003931752267
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	19/835	149/9376	1.43185307237873	INSR/PIK3R1/GRM8/PDGFRA/AKT3/PTPN11/LPAR2/MAPK1/SOS1/FYN/SOS2/AGPAT4/RAF1/PLCB1/MRAS/PIK3CA/PDGFC/AGT/TSC1	1.6613969260959
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	32/835	275/9376	1.30661731083288	TUBB2B/EGR1/HSPA1A/LAMC1/HSPA1B/GRIN3A/PIK3R1/MT-ATP6/MT-ND1/MAPK10/PPP3R1/MT-ND4/MT-ND2/TUBB4A/CAV2/CACNA1B/MAPK1/FYN/TUBB2A/NCAM1/ATF2/CREB1/NCAM2/PIK3CA/MT-ND4L/CAV1/TUBA1A/PPP3CB/ITPR2/PPP3R2/GRIN2C/CREB5	1.61358918772583
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	12/835	86/9376	1.56680128115861	ACTG1/LEF1/JUP/CTNNB1/CTNNA1/SGCE/ITGB8/PKP2/DMD/ATP2A2/ITGA5/SGCB	1.65099860709252
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	17/835	133/9376	1.43525280266535	HLA-C/PIK3R1/PPP3R1/HLA-E/PTPN11/MAPK1/SOS1/FYN/IFNAR1/SOS2/RAF1/VAV3/PIK3CA/MICA/PPP3CB/BRAF/PPP3R2	1.580648979467
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	9/835	60/9376	1.68431137724551	PIK3R1/PPP3R1/AKT3/MAPK1/RAF1/PIK3CA/PPP3CB/PPP3R2/PTK2	1.66260530089525
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	11/835	78/9376	1.58354061108552	FOS/C3/HLA-DQA2/JUN/TGFB2/TLR4/HLA-DQA1/MAPK1/NFKBIA/HLA-DQB1/JAK1	1.61807307521545
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	3/835	12/9376	2.80718562874251	CD46/NCAM1/NCAM2	1.95856143960517
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	13/835	97/9376	1.50488301747021	FOS/GNAQ/GNG12/MAPK1/CAMK2D/CREB1/GNAI1/GRIA1/PLCB1/GRIA2/GNB1/GNG4/GRIN2C	1.56278976233811
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	21/835	174/9376	1.35519306215156	HSP90AA1/HSPA1A/PPP1R15A/HSPH1/DNAJB1/HSPA1B/DNAJA1/MAPK10/NFE2L2/HSP90AB1/CANX/MAN1C1/OS9/EDEM3/DNAJC1/DERL3/RAD23B/CAPN2/ATXN3/BCAP29/ERO1A	1.47867421234463
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	15/835	117/9376	1.43958237371411	ACTG1/BAZ2B/SMARCA5/BPTF/SMARCA1/BRD8/ARID2/ARID1B/SMARCC2/BAZ1B/RBBP4/BAZ1A/HDAC2/PBRM1/BCL7A	1.49597960823171
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	10/835	71/9376	1.58151303027747	JUN/LYN/MAPK10/ADAM10/PTPN11/CXCL2/NFKBIA/ADAM17/ATP6V1D/ATP6V1C1	1.53781804004919
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	24/835	205/9376	1.31458448955747	COL3A1/INSR/PIK3R1/MT-ATP6/MT-ND1/TGFB2/MAPK10/SMAD3/MT-ND4/MT-ND2/COL1A2/AKT3/PPP1CB/TBC1D4/CAMK2D/MMP2/ATP2A2/PLCB1/TGFBR1/PIK3CA/MT-ND4L/SMAD2/AGT/TGFBR2	1.42390299970095
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	26/835	226/9376	1.29180223623549	FOS/JUN/AFDN/GRIN3A/PIK3R1/MAPK10/EP300/AKT3/NPY/PPP1CB/MAPK1/NFKBIA/PTGER3/CAMK2D/RAF1/CREB1/GNAI1/GRIA1/ATP2A2/CREBBP/VAV3/GRIA2/PIK3CA/BRAF/GRIN2C/CREB5	1.38837505905428
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	14/835	110/9376	1.42911268372346	HSP90AA1/RPS6KA2/PGR/PIK3R1/MAPK10/AKT3/HSP90AB1/MAPK1/CPEB2/RAF1/GNAI1/PIK3CA/CDC16/BRAF	1.41545498171085
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	18/835	149/9376	1.3564923843588	GNAQ/MT-ND1/MAPK10/MT-ND4/MT-ND2/GNG12/CACNA1B/GABRE/MAPK1/GNAI1/GRIA1/PLCB1/GRIA2/MT-ND4L/ITPR2/GABRQ/GNB1/GNG4	1.37147421063358
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	6/835	38/9376	1.77295934446896	NEDD4L/INSR/PIK3R1/SGK1/MAPK1/PIK3CA	1.49278076480358
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	21/835	180/9376	1.31001996007984	C3/HLA-DQA2/SOCS3/HLA-C/PIK3R1/HLA-E/AKT3/PTPN11/HLA-DQA1/PPP1CB/IFNAR1/NFKBIA/HLA-DQB1/PIK3CA/STAT2/ITGA5/PILRA/HCFC2/ZC3HAV1/TSC1/JAK1	1.3131094967294
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	28/835	250/9376	1.25761916167665	LAMP5/MITF/LAPTM4A/VPS13C/VPS41/TPP1/DEPTOR/LAMP2/PSAP/CTSB/IGF2R/GALC/VPS13A/SCARB2/CD164/OSTM1/DMXL1/GNS/IDS/CLTC/ATP6V1D/NCOA7/ATP6V1C1/ARL8B/MCOLN3/GNPTAB/GPR155/VPS26A	1.29086982737354
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	13/835	103/9376	1.41721992907389	PPP2R3A/PPP1CB/SMG1/PPP2CB/GSPT1/PABPC4L/PAPOLG/DDX39B/PCF11/MSI2/PAPOLA/CASC3/ETF1	1.33121450901243
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	10/835	75/9376	1.49716566866267	GADD45G/GADD45B/SERPINE1/CCNG2/GADD45A/MDM2/PMAIP1/RPRM/THBS1/PPM1D	1.35157906331045
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	50/835	480/9376	1.16966067864271	TUBB2B/APP/RB1CC1/GNAQ/WNT2/SNCAIP/WNT5A/MT-ATP6/MT-ND1/DKK2/MAPK10/PPP3R1/CTNNB1/AXIN2/MT-ND4/DKK1/MT-ND2/TUBB4A/HAP1/CASP7/DNAH14/CACNA1B/OPTN/TANK/MAPK1/TUBB2A/CAMK2D/ATXN1/RAF1/GRIA1/ATP2A2/MAP1LC3B/PLCB1/GRIA2/MT-ND4L/TUBA1A/WNT16/PPP3CB/ITPR2/BRAF/PPP3R2/CAPN2/C9orf72/ATXN3/CSNK1E/FZD3/GRIN2C/CSNK1A1/PIK3C3/APC	1.19310577113802
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	12/835	95/9376	1.41836747557517	FOS/CXCL12/HLA-DQA2/JUN/TGFB2/TLR4/CXCL2/HLA-DQA1/HLA-DQB1/IL15/ATP6V1D/ATP6V1C1	1.28143577931141
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	15/835	125/9376	1.34744910179641	GNAQ/PPP2R3A/PIK3R1/MAPK10/S1PR3/AKT3/MAPK1/FYN/CERS6/PPP2CB/RAF1/GNAI1/PLCB1/PIK3CA/ABCC1	1.22271819343878
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	8/835	59/9376	1.52254135796204	INSR/PIK3R1/IRS2/AKT3/NPY/PTGER3/GNAI1/PIK3CA	1.25887654694657
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	10/835	78/9376	1.43958237371411	INPP4B/PPIP5K2/PIK3C2A/SACM1L/PLCB1/IPMK/PIK3CA/ALDH6A1/INPP5K/PIK3C3	1.21889786200648
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	6/835	41/9376	1.64323061194684	MAPK1/MDM2/RAF1/MMP2/THBS1/BRAF	1.29055342265716
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	16/835	138/9376	1.30188319014146	RPS6KA2/PGR/AR/PPP3R1/SMC1A/PPP1CB/MAPK1/CPEB2/CAMK2D/PPP2CB/YWHAZ/SLK/CDC16/PPP3CB/ITPR2/PPP3R2	1.11702787265658
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	11/835	89/9376	1.38782210859181	SLC38A2/HAP1/GNG12/CACNA1B/GABRE/GNAI1/GLUL/GABRQ/GLS/GNB1/GNG4	1.14938191347479
Human Diseases	Substance dependence	hsa05034	Alcoholism	21/835	191/9376	1.23457378436844	SLC18A2/FOSB/GRIN3A/GNG12/NPY/PPP1CB/MAPK1/SOS1/SOS2/ATF2/RAF1/CREB1/GNAI1/MAOB/BRAF/GNB1/GNG4/GRIN2C/MAOA/HDAC2/CREB5	1.02407341663351
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	3/835	17/9376	1.98154279675942	CA2/CA8/GLUL	1.26646587533669
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	6/835	44/9376	1.53119216113228	HLA-DQA2/HLA-C/HLA-E/HLA-DQA1/HSPD1/HLA-DQB1	1.10424424790191
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	19/835	173/9376	1.23321449586376	DNAJB1/HLA-DQA2/SOCS3/ACTG1/PIK3R1/EP300/CALCOCO2/AKT3/TLR4/HLA-DQA1/MAPK1/IFNAR1/NFKBIA/HLA-DQB1/RAF1/CREBBP/PIK3CA/STAT2/JAK1	0.968029064268263
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	16/835	144/9376	1.2476380572189	C3/PRKAA2/LEF1/MAPK10/CTNNB1/FOXO1/AKT3/TLR4/CXCL2/ALDH3A2/C2/NFKBIA/SIRT1/FOXO3/SREBF1/TRA2A	0.936322050853275
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	7/835	55/9376	1.42911268372346	PSAP/GALC/SAMD8/CERS6/ACER3/UGCG/B4GALT6	0.99792053003427
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	9/835	75/9376	1.34744910179641	GNAQ/LRP2/TTR/CANX/ATF2/CREB1/PLCB1/ITPR2/CREB5	0.944564279382432
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	17/835	156/9376	1.22364501765699	STAT3/SOCS3/PIK3R1/CTNNB1/AKT3/MAPK1/SOS1/IFNAR1/NFKBIA/SOS2/PPP2CB/RAF1/YWHAZ/PIK3CA/STAT2/BRAF/JAK1	0.880705241615474
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	7/835	56/9376	1.40359281437126	BOC/LRP2/CUL3/CSNK1G3/SMURF2/CSNK1E/CSNK1A1	0.947117797739889
NA	NA	hsa04082	Neuroactive ligand signaling	21/835	199/9376	1.18494267745915	SLC18A2/GNAQ/HRH1/GRIK2/GRIN3A/GRM8/GNAL/HTR2A/OGFRL1/GNG12/GABRE/GNAI1/GRIA1/PLCB1/GRIA2/HTR7/GABRQ/SLC1A2/GNB1/GNG4/GRIN2C	0.824494623714397
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	12/835	109/9376	1.23619183651047	FOS/JUN/PIK3R1/MAPK10/AKT3/TLR4/MAPK1/IFNAR1/NFKBIA/PIK3CA/STAT2/JAK1	0.775502255913057
Human Diseases	Immune disease	hsa05330	Allograft rejection	5/835	39/9376	1.43958237371411	HLA-DQA2/HLA-C/HLA-E/HLA-DQA1/HLA-DQB1	0.860089030931619
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	11/835	99/9376	1.2476380572189	GNAQ/HRH1/PIK3R1/MAPK10/HTR2A/PPP1CB/CAMK2D/NTRK1/PLCB1/PIK3CA/ITPR2	0.774472002093072
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	11/835	99/9376	1.2476380572189	PRKAA2/ACTG1/TPM4/TGFB2/SGCE/ITGB8/DMD/ATP2A2/ITGA5/AGT/SGCB	0.774472002093072
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	6/835	50/9376	1.34744910179641	CXCL12/HLA-DQA2/HLA-DQA1/HLA-DQB1/IL15/IL15RA	0.770199096669368
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	14/835	134/9376	1.17315220305657	PLA2G2A/GNAQ/ARHGEF12/MYH10/PPP1CB/MAPK1/RAF1/PLCB1/PPP1R12B/ITPR2/BRAF/AGT/MYLK/MYH9	0.631207213878982
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	3/835	22/9376	1.53119216113228	ALDH3A2/MAOB/MAOA	0.779899837952549
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	4/835	32/9376	1.40359281437126	MAPK10/CASP7/PMAIP1/BIRC6	0.715033706271375
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	8/835	73/9376	1.23054712492823	MAP1B/PDCD6IP/EP300/RANBP2/ELL2/AFF4/CREBBP/SAMHD1	0.618278500896075
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	3/835	23/9376	1.46461858890914	MME/ENPEP/AGT	0.697524629875292
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	23/835	235/9376	1.09898330997579	RPS6KA2/PRKAA2/ACTG1/MT-ATP6/MT-ND1/MT-ND4/MT-ND2/ZNF516/FRS2/PPARG/SOS1/SOS2/FGFR1/ATF2/CREB1/ARID1B/SMARCC2/MT-ND4L/KDM3A/ACSL1/TSC1/CREB5/ACSL3	0.480478063045392
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/835	14/9376	1.60410607356715	B3GNT2/CHST2	0.707240978781053
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	8/835	76/9376	1.18197289631264	GNAQ/ACTG1/CA2/CAMK2D/GNAI1/PLCB1/ITPR2/MYLK	0.498019725198179
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	5/835	45/9376	1.2476380572189	ABCB1/ABCC3/ABCC1/ABCA1/ABCD2	0.520635845073242
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	5/835	45/9376	1.2476380572189	HLA-DQA2/HLA-C/HLA-E/HLA-DQA1/HLA-DQB1	0.520635845073242
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	10/835	98/9376	1.14579005254797	PIK3R1/INPP4B/PPIP5K2/PIK3C2A/SACM1L/PLCB1/IPMK/PIK3CA/ITPR2/PIK3C3	0.453615892013873
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	10/835	98/9376	1.14579005254797	NR4A1/GNAQ/CAMK2D/ATF2/CREB1/PLCB1/ITPR2/AGT/PRKD3/CREB5	0.453615892013873
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	6/835	56/9376	1.20307955517536	ST6GAL2/MGAT4A/ST6GAL1/MAN1C1/MGAT5/ALG13	0.476570083050974
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	10/835	99/9376	1.13421641565354	C3/C1S/HLA-DQA2/CFD/HLA-DQA1/MASP1/C2/CFI/HLA-DQB1/C1R	0.41975315632957
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	8/835	78/9376	1.15166589897129	XRN1/BTG1/HSPD1/DDX6/XRN2/BTG2/PABPC4L/CNOT6	0.420547435588544
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	15/835	154/9376	1.09370868652306	GNAQ/PPP2R3A/TPM4/AKT3/PPP1CB/MAPK1/CAMK2D/PPP2CB/ATF2/CREB1/GNAI1/ATP2A2/PLCB1/AGT/CREB5	0.366608193574433
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	4/835	36/9376	1.2476380572189	C1GALT1/GALNT3/GALNT13/GALNTL6	0.465446442748241
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	29/835	308/9376	1.05725173030562	TUBB2B/RB1CC1/GNAQ/SOD2/MT-ATP6/MT-ND1/MAPK10/MT-ND4/MT-ND2/EP300/TUBB4A/HAP1/DNAH14/CACNA1B/PPARG/TUBB2A/CREB1/GRIA1/CREBBP/PLCB1/GRIA2/MT-ND4L/TUBA1A/CLTC/SLC1A2/REST/PIK3C3/HDAC2/CREB5	0.319435172801788
Human Diseases	Substance dependence	hsa05032	Morphine addiction	9/835	91/9376	1.11053497400803	PDE8B/GNG12/CACNA1B/GABRE/GNAI1/GABRQ/PDE7A/GNB1/GNG4	0.331286676929364
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/835	16/9376	1.40359281437126	MAOB/MAOA	0.505172856466101
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	5/835	48/9376	1.16966067864271	PIK3R1/AKT3/PLCB1/PIK3CA/HK1	0.368452972742143
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	15/835	157/9376	1.07280979442389	FOS/SOCS3/JUN/PRKAA2/INSR/PIK3R1/MAPK10/IRS2/AKT3/CASP7/PPARG/PIK3CA/SREBF1/ITCH/CEBPA	0.28765520616119
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	2/835	17/9376	1.32102853117295	GGT5/FMO1	0.414216966475943
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	3/835	28/9376	1.20307955517536	CA2/ATP6V1D/ATP6V1C1	0.336480873120007
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	10/835	105/9376	1.06940404904477	ACTG1/TPM4/TGFB2/SGCE/ITGB8/DMD/ATP2A2/ITGA5/AGT/SGCB	0.223609722174198
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	5/835	50/9376	1.12287425149701	HGF/SDC2/TGFB2/TLR4/THBS1	0.272378420371836
Cellular Processes	Cell motility	hsa04814	Motor proteins	18/835	194/9376	1.04184208901784	TUBB2B/ACTG1/TPM4/DYNC1H1/KIF26B/TUBB4A/KIF1B/MYO9A/DNAH14/HOOK3/MYH10/TUBB2A/MYO1E/TUBA1A/KIF21A/KIF27/MYH9/DYNC1I2	0.184128109796408
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	5/835	51/9376	1.10085710931079	ACTG1/SLC12A2/ATP6V1D/ATP6V1C1/ERO1A	0.225809234977017
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/835	18/9376	1.2476380572189	ACSL1/ACSL3	0.328803654093714
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	10/835	108/9376	1.03969838101575	RANBP2/KPNA4/DDX39B/IPO5/TNPO1/IPO7/TPR/IPO8/AHCTF1/CASC3	0.129737694446564
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/835	19/9376	1.18197289631264	GNS/IDS	0.248250257812579
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	4/835	42/9376	1.06940404904477	ALDH3A2/MAOB/AOX1/MAOA	0.140945128513022
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	5/835	54/9376	1.03969838101575	HLA-DQA2/HLA-C/HLA-E/HLA-DQA1/HLA-DQB1	0.0914723088619173
Human Diseases	Immune disease	hsa05310	Asthma	3/835	32/9376	1.05269461077844	HLA-DQA2/HLA-DQA1/HLA-DQB1	0.0933575165458175
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	4/835	44/9376	1.02079477408819	DYNC1H1/CREB1/CREB5/DYNC1I2	0.043228254017066
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	9/835	102/9376	0.990771398379711	CD38/PLA2G2A/GNAQ/SLC12A2/CLCA1/CA2/ATP2A2/PLCB1/ITPR2	-0.0293006297016011
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	7/835	79/9376	0.994951868415069	SLC18A2/STX3/CACNA1B/CLTC/SLC1A2/ATP6V1D/ATP6V1C1	-0.0140879341151995
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/835	21/9376	1.06940404904477	ALDH3A2/PANK3	0.0995513318151354
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	9/835	105/9376	0.962463644140291	CXCL12/GADD45G/LYN/GADD45B/TNFAIP3/GADD45A/TLR4/CXCL2/NFKBIA	-0.120936663216974
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/835	23/9376	0.976412392606092	GLUL/GLS	-0.0354117065262252
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/835	23/9376	0.976412392606092	CA2/GLS	-0.0354117065262252
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	6/835	73/9376	0.922910343696169	GSTA1/GSTA4/MAOB/FMO1/AOX1/MAOA	-0.206738111130054
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	20/835	238/9376	0.943591807980677	FOS/C3/STAT3/C1S/JUN/IL6ST/PIK3R1/MAPK10/TLR4/CFD/MASP1/MAPK1/C2/IFNAR1/NFKBIA/ADAM17/PIK3CA/STAT2/C1R/JAK1	-0.275600243363809
Organismal Systems	Digestive system	hsa04978	Mineral absorption	5/835	61/9376	0.920388730735251	SLC40A1/FTL/CYBRD1/MT2A/TRPM7	-0.195039489232841
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	14/835	168/9376	0.935728542914172	HSP90AA1/STAT3/FTL/MAPK10/HSP90AB1/TNFAIP3/TLR4/IFNAR1/CAMK2D/GLUL/TRPM7/STAT2/CAPN2/JAK1	-0.262823773492723
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	3/835	37/9376	0.91043858229487	MAOB/AOX1/MAOA	-0.170665661706041
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/835	37/9376	0.91043858229487	GNAQ/LAMA4/PLCB1	-0.170665661706041
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	7/835	86/9376	0.913967414009191	PCLO/GNAQ/CAMK2D/ATF2/CREB1/PLCB1/CREB5	-0.250598727203027
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	4/835	50/9376	0.898299401197605	ALDH3A2/P4HA2/MAOB/MAOA	-0.225442255925696
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	5/835	63/9376	0.89117004087064	PLA2G2A/AKR1C3/HPGD/GGT5/PTGIS	-0.270986998298042
NA	NA	hsa04081	Hormone signaling	18/835	219/9376	0.922910343696169	DIO2/STAT3/TRH/SLC40A1/INSR/GNAQ/GNA14/PIK3R1/IRS2/GNG12/ESR1/GNAI1/PLCB1/PIK3CA/AGT/PRLR/GNB1/GNG4	-0.360924260030834
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	8/835	100/9376	0.898299401197605	CD44/CD38/HLA-DQA2/MME/CD24/HLA-DQA1/HLA-DQB1/ITGA5	-0.319681610930446
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/835	13/9376	0.863749424228466	LIG4	-0.153701117705696
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4/835	53/9376	0.847452265280759	GNAQ/ESR1/PLCB1/CLTC	-0.348209303605685
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/835	28/9376	0.802053036783576	B3GNT2/B3GALT5	-0.32797672299903
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	3/835	43/9376	0.783400640579306	ALDH3A2/ACSL1/ACSL3	-0.445097625863594
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	5/835	70/9376	0.802053036783576	GSTA1/SULT1A1/AKR1C2/GSTA4/EPHX1	-0.51974563943303
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	6/835	83/9376	0.811716326383378	SOD2/PEX1/NUDT7/ACSL1/ABCD2/ACSL3	-0.538701588144744
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/835	30/9376	0.748582834331337	ABCC3/ABCC1	-0.431238155819767
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	3/835	44/9376	0.76559608056614	MGAT4A/MAN1C1/ALG13	-0.487279742925356
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/835	16/9376	0.701796407185629	B3GALT5	-0.373258282670799
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/835	31/9376	0.72443500096581	ALDH3A2/ALDH6A1	-0.480495985767559
NA	NA	hsa04981	Folate transport and metabolism	2/835	31/9376	0.72443500096581	ABCC3/ABCC1	-0.480495985767559
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	4/835	59/9376	0.761270678981021	GSTA1/GGT5/GSTA4/LANCL1	-0.575132932006317
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	2/835	32/9376	0.701796407185629	PPP2CB/PIK3C3	-0.52831867317974
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/835	17/9376	0.660514265586474	TXNRD1	-0.438031942384808
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	2/835	33/9376	0.680529849392125	STX3/STX6	-0.574802432058244
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	3/835	48/9376	0.701796407185629	ALDH3A2/AOX1/ALDH6A1	-0.647610283855013
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/835	18/9376	0.623819028609448	MAN2B2	-0.499477662613073
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	5/835	76/9376	0.738733060195399	FABP5/SLC27A6/PPARG/ACSL1/ACSL3	-0.715030052284881
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	20/835	268/9376	0.837965859326124	SLC18A2/TUBB2B/DUSP1/SNCAIP/MT-ATP6/MT-ND1/MAPK10/NFE2L2/MT-ND4/GNAL/MT-ND2/TUBB4A/TUBB2A/CAMK2D/GNAI1/MT-ND4L/MAOB/TUBA1A/ITPR2/MAOA	-0.841466694790642
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	28/835	368/9376	0.854360843530331	TUBB2B/RB1CC1/ACTG1/MT-ATP6/MT-ND1/PPP3R1/MT-ND4/MT-ND2/TUBB4A/HAP1/DNAH14/OPTN/TANK/SETX/RANBP2/TUBB2A/GRIA1/MAP1LC3B/GRIA2/MT-ND4L/TUBA1A/PPP3CB/SLC1A2/PPP3R2/TPR/C9orf72/GRIN2C/PIK3C3	-0.891173759891247
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/835	36/9376	0.623819028609448	PGM2L1/HK1	-0.707048411418204
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/835	51/9376	0.660514265586474	PLA2G2A/ENPP2/PAFAH1B1	-0.760075462179916
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/835	20/9376	0.561437125748503	LBR	-0.613869803452811
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	4/835	66/9376	0.680529849392125	AKR1C3/HSD17B6/AKR1C2/HSD17B11	-0.814332801806245
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	3/835	52/9376	0.64781206817135	MYLIP/LRP2/ABCA1	-0.796250145366864
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/835	37/9376	0.606959054863247	GLUL/GLS	-0.748967520815489
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	2/835	38/9376	0.590986448156319	GNPDA2/HK1	-0.789909025753115
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4/835	68/9376	0.660514265586474	ALDH1A1/HSD17B6/RDH10/AOX1	-0.878460652283651
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	5/835	83/9376	0.676430271986148	IFI16/CASP7/NFKBIA/GSDME/SAMHD1	-0.92577079578097
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/835	23/9376	0.488206196303046	B3GALNT2	-0.768348042927742
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/835	23/9376	0.488206196303046	MSH2	-0.768348042927742
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	2/835	41/9376	0.547743537315613	MAOB/MAOA	-0.907390156804902
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	4/835	72/9376	0.623819028609448	DDX3X/MAPK10/TANK/NFKBIA	-1.00185007707166
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/835	43/9376	0.522267093719538	PLA2G2A/ABCA1	-0.981710116553713
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/835	26/9376	0.431874712114233	PLA2G2A	-0.906983746059073
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/835	26/9376	0.431874712114233	ABCC1	-0.906983746059073
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	2/835	44/9376	0.510397387044094	GTF2I/TAF7	-1.01778773986778
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	2/835	44/9376	0.510397387044094	TDG/POLB	-1.01778773986778
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/835	46/9376	0.488206196303046	FTL/CPOX	-1.08794673342061
NA	NA	hsa04382	Cornified envelope formation	14/835	217/9376	0.72443500096581	LAMA3/PPP2R3A/S100A6/COL4A1/JUP/COL7A1/COL4A2/DST/S100A3/PKP2/PPP2CB/COL4A4/UGCG/S100A4	-1.28411644304089
Organismal Systems	Digestive system	hsa04970	Salivary secretion	5/835	93/9376	0.603695834138175	CD38/GNAQ/SLC12A2/PLCB1/ITPR2	-1.20088232181616
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/835	28/9376	0.401026518391788	AKR1C3	-0.992434319118067
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	20/835	298/9376	0.753606880199333	IL32/IL17RB/CXCL12/OSMR/IL6ST/TGFB2/TNFRSF12A/CXCL2/IL13RA1/IFNAR1/IL15/TGFBR1/BMPR2/IL15RA/CXCL13/ACVR2B/TGFBR2/PRLR/ACVR2A/CLCF1	-1.35150026257251
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/835	29/9376	0.387198017757588	GNB1	-1.03337405637581
NA	NA	hsa03272	Virion - Hepatitis viruses	2/835	48/9376	0.467864271457086	PDCD6IP/LAMP2	-1.15564191215359
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/835	30/9376	0.374291417165669	PLA2G2A	-1.07323386064132
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/835	31/9376	0.362217500482905	H6PD	-1.11208583051123
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/835	31/9376	0.362217500482905	ALDH3A2	-1.11208583051123
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/835	31/9376	0.362217500482905	GLUL	-1.11208583051123
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/835	31/9376	0.362217500482905	SPCS3	-1.11208583051123
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/835	32/9376	0.350898203592814	HK1	-1.1499948629053
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/835	32/9376	0.350898203592814	ALDH6A1	-1.1499948629053
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	2/835	52/9376	0.431874712114233	INSR/AKR1C3	-1.28445583219395
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	2/835	54/9376	0.415879352406298	REV3L/WDR48	-1.34592048648334
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/835	35/9376	0.32082121471343	HK1	-1.25862386736212
Organismal Systems	Digestive system	hsa04976	Bile secretion	4/835	90/9376	0.499055222887558	ABCB1/ABCC3/CA2/EPHX1	-1.49303944990015
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	24/835	370/9376	0.728350865835896	C3/TRH/HRH1/GRIK2/GRIN3A/GRM8/S1PR3/HTR2A/OGFRL1/LPAR2/NPY/GABRE/PTGER3/GRID2/GRIA1/GRIA2/HTR7/GABRQ/TMEM97/AGT/EDNRB/PRLR/GRIN2C/VGF	-1.66693141299633
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	7/835	138/9376	0.569573895686887	MT-ATP6/MT-ND1/MT-ND4/MT-ND2/MT-ND4L/ATP6V1D/ATP6V1C1	-1.59266223273792
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	2/835	57/9376	0.393990965437546	ACSL1/ACSL3	-1.43484961583302
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/835	37/9376	0.303479527431623	HK1	-1.32726937992494
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/835	39/9376	0.287916474742822	ALDH1L2	-1.39326612212877
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	7/835	143/9376	0.549658724509024	C3/C1S/HLA-DQA2/HLA-DQA1/C2/HLA-DQB1/C1R	-1.69673051097568
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3/835	79/9376	0.426407943606458	GSTA1/GSTA4/EPHX1	-1.60073622557599
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	1/835	41/9376	0.273871768657806	BARD1	-1.45687605167042
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	2/835	63/9376	0.356468016348256	CUL4B/RAD23B	-1.60239700495784
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	4/835	100/9376	0.449149700598802	CXCL12/IL6ST/CXCL2/CXCL13	-1.73152088746547
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	2/835	65/9376	0.345499769691386	ALDH3A2/AGPAT4	-1.65555202841905
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	10/835	195/9376	0.575832949485644	C3/ACTG1/PIK3R1/AKT3/TLR4/MAPK1/RAF1/PLCB1/PIK3CA/HDAC2	-1.87147382059081
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	2/835	67/9376	0.33518634373045	ALDH3A2/HK1	-1.70749850903883
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	4/835	104/9376	0.431874712114233	PLA2G2A/SAMD8/AGPAT4/LPGAT1	-1.82158144499321
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	1/835	46/9376	0.244103098151523	PSME4	-1.60684939760575
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	3/835	87/9376	0.387198017757588	TPM4/ATP2A2/SLC9A7	-1.79543555525709
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	1/835	47/9376	0.238909415212129	ALDH3A2	-1.63546873760558
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	2/835	82/9376	0.273871768657806	GSTA1/GSTA4	-2.06487339812671
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/835	59/9376	0.190317669745255	NT5E	-1.95064004122098
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	3/835	116/9376	0.290398513318191	H6PD/ALDH6A1/HK1	-2.40443218679123
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	1/835	75/9376	0.149716566866267	GLUL	-2.31155399204169
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	3/835	128/9376	0.263173652694611	NT5E/PDE8B/PDE7A	-2.62434384449559
Genetic Information Processing	Transcription	hsa03040	Spliceosome	9/835	243/9376	0.415879352406298	DDX5/HSPA1A/HNRNPU/HSPA1B/SF3B1/WBP11/DDX39B/TRA2A/CASC3	-2.88451951179412
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	4/835	154/9376	0.291655649739482	HSD17B6/ALDH3A2/PANK3/CPOX	-2.77119285642497
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	1/835	85/9376	0.132102853117295	NT5E	-2.51316503291534
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/835	86/9376	0.130566773429884	PLCB1	-2.53251552835768
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	2/835	183/9376	0.122718497431367	XRN1/XRN2	-3.74723044750905
Genetic Information Processing	Translation	hsa03010	Ribosome	1/835	222/9376	0.0505799212386039	MRPL42	-4.47614308012568
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	4/835	449/9376	0.100033340890602	GNAL/RGS2/CAMK2D/GNB1	-6.11042388490348