ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 75/1602 349/18639 0.214899713467049 2.50032194713628 6.82917583463779e-14 8.1676942982268e-11 GO:0140297 DNA-binding transcription factor binding 93/1602 488/18639 0.190573770491803 2.21729370049733 1.48403837380773e-13 8.87454947537023e-11 GO:0005201 extracellular matrix structural constituent 45/1602 168/18639 0.267857142857143 3.11647271268058 2.9305256487244e-12 1.16830289195813e-09 GO:0046332 SMAD binding 29/1602 79/18639 0.367088607594937 4.27101408050064 4.62893163119659e-12 1.38405055772778e-09 GO:0045296 cadherin binding 63/1602 334/18639 0.188622754491018 2.19459395815111 2.01513646365434e-09 4.82020642106118e-07 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 80/1602 484/18639 0.165289256198347 1.92311263812796 8.79065459855282e-09 1.75227048331153e-06 GO:0001216 DNA-binding transcription activator activity 80/1602 491/18639 0.162932790224033 1.895695553674 1.69190176611461e-08 2.89073501753296e-06 GO:0003779 actin binding 74/1602 443/18639 0.167042889390519 1.94351586476273 2.02588091814843e-08 3.0286919726319e-06 GO:0001217 DNA-binding transcription repressor activity 53/1602 278/18639 0.190647482014388 2.21815132163932 2.62535196064112e-08 3.48880104991864e-06 GO:0030020 extracellular matrix structural constituent conferring tensile strength 17/1602 44/18639 0.386363636363636 4.49527579162411 5.07406775425948e-08 5.63776898122997e-06 GO:0003712 transcription coregulator activity 79/1602 495/18639 0.15959595959596 1.85687209170355 5.18523902955933e-08 5.63776898122997e-06 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 49/1602 268/18639 0.182835820895522 2.12726396109341 3.29146315040661e-07 3.28049160657192e-05 GO:0044389 ubiquitin-like protein ligase binding 55/1602 322/18639 0.170807453416149 1.98731593272385 6.37405367010066e-07 5.86412937649261e-05 GO:0051020 GTPase binding 54/1602 315/18639 0.171428571428571 1.99454253611557 7.15194239266783e-07 6.10980221545051e-05 GO:0005543 phospholipid binding 75/1602 497/18639 0.150905432595573 1.75575927474962 1.0641148438983e-06 8.4845423553491e-05 GO:0001221 transcription coregulator binding 27/1602 115/18639 0.234782608695652 2.73165608207132 1.14073003198179e-06 8.52695698906385e-05 GO:0003714 transcription corepressor activity 39/1602 204/18639 0.191176470588235 2.22430601454065 1.63766848698477e-06 0.000114233024654893 GO:0031267 small GTPase binding 49/1602 283/18639 0.173144876325088 2.01451145432167 1.71922612356863e-06 0.000114233024654893 GO:0008013 beta-catenin binding 25/1602 106/18639 0.235849056603774 2.74406402374391 2.5748682986228e-06 0.000162081183429099 GO:0019838 growth factor binding 29/1602 136/18639 0.213235294117647 2.48095670852611 3.75400883065442e-06 0.000216123406822564 GO:0017124 SH3 domain binding 26/1602 115/18639 0.226086956521739 2.6304836345872 3.79480898267044e-06 0.000216123406822564 GO:0035091 phosphatidylinositol binding 48/1602 284/18639 0.169014084507042 1.96645038771958 4.36247901576907e-06 0.000227581200315492 GO:0016922 nuclear receptor binding 29/1602 137/18639 0.211678832116788 2.46284753547117 4.37656154452869e-06 0.000227581200315492 GO:0031625 ubiquitin protein ligase binding 50/1602 302/18639 0.165562913907285 1.92629659944936 5.06636104027743e-06 0.000252473658507158 GO:0141003 histone H2AX kinase activity 56/1602 354/18639 0.15819209039548 1.84053831016314 5.88196488591905e-06 0.000281393200142368 GO:0005518 collagen binding 19/1602 72/18639 0.263888888888889 3.07030274656679 7.09974962801012e-06 0.000326588482888466 GO:0140996 histone H3 kinase activity 56/1602 357/18639 0.156862745098039 1.82507160167438 7.60885325929373e-06 0.000337044018448715 GO:0035173 histone kinase activity 56/1602 360/18639 0.155555555555556 1.80986267166042 9.79711560822561e-06 0.000418476795265637 GO:0019199 transmembrane receptor protein kinase activity 19/1602 78/18639 0.243589743589744 2.8341256122155 2.45805702865759e-05 0.00101373662285327 GO:0030695 GTPase regulator activity 69/1602 489/18639 0.141104294478528 1.641724684635 2.81051309116862e-05 0.00112045788567922 GO:0005096 GTPase activator activity 44/1602 271/18639 0.162361623616236 1.88905012645632 2.98726062756879e-05 0.00112246667125847 GO:0060589 nucleoside-triphosphatase regulator activity 69/1602 490/18639 0.140816326530612 1.63837422609493 3.00325530771496e-05 0.00112246667125847 GO:0070412 R-SMAD binding 10/1602 26/18639 0.384615384615385 4.47493517718237 3.144425681295e-05 0.00113961609540267 GO:0051015 actin filament binding 36/1602 209/18639 0.172248803827751 2.00408580183861 4.37164340610113e-05 0.00153778985696969 GO:0004674 protein serine/threonine kinase activity 62/1602 433/18639 0.143187066974596 1.66595739159769 4.56260991082013e-05 0.00155910898666882 GO:0003725 double-stranded RNA binding 18/1602 75/18639 0.24 2.7923595505618 4.93316939216336e-05 0.00163890849806316 GO:0097718 disordered domain specific binding 10/1602 28/18639 0.357142857142857 4.15529695024077 6.62166930976831e-05 0.00214040986337376 GO:0042826 histone deacetylase binding 25/1602 127/18639 0.196850393700787 2.29032115367602 7.00307972571299e-05 0.0022041271978823 GO:1990841 promoter-specific chromatin binding 16/1602 68/18639 0.235294117647059 2.73760740251157 0.000163534959275093 0.00501507208443619 GO:0005024 transforming growth factor beta receptor activity 7/1602 16/18639 0.4375 5.09023876404494 0.000195071138074891 0.00583262702843924 GO:0005160 transforming growth factor beta receptor binding 9/1602 26/18639 0.346153846153846 4.02744165946413 0.000202751907415395 0.00591442149436127 GO:0031490 chromatin DNA binding 24/1602 128/18639 0.1875 2.1815308988764 0.000212219560295011 0.00604320462173413 GO:0097677 STAT family protein binding 6/1602 12/18639 0.5 5.81741573033708 0.000234173320683748 0.00634643360799716 GO:0097110 scaffold protein binding 16/1602 70/18639 0.228571428571429 2.65939004815409 0.000234236416207703 0.00634643360799716 GO:0035591 signaling adaptor activity 24/1602 129/18639 0.186046511627907 2.16461980663705 0.000239856808825446 0.00634643360799716 GO:0001223 transcription coactivator binding 12/1602 44/18639 0.272727272727273 3.17313585291113 0.000244093600307583 0.00634643360799716 GO:0005178 integrin binding 28/1602 161/18639 0.173913043478261 2.02344894968246 0.000250208254888105 0.00636700154991859 GO:0106310 protein serine kinase activity 51/1602 361/18639 0.141274238227147 1.64370195150798 0.000289202939020879 0.00720597323060358 GO:0051219 phosphoprotein binding 19/1602 93/18639 0.204301075268817 2.37700857798719 0.000303936880683044 0.00734521725458582 GO:1990226 histone methyltransferase binding 7/1602 17/18639 0.411764705882353 4.79081295439524 0.000307074299940879 0.00734521725458582 GO:0140416 transcription regulator inhibitor activity 10/1602 33/18639 0.303030303030303 3.52570650323459 0.000313652478738147 0.00735545812883968 GO:0004713 protein tyrosine kinase activity 25/1602 140/18639 0.178571428571429 2.07764847512039 0.000346901041824344 0.00785232460876364 GO:0019209 kinase activator activity 26/1602 148/18639 0.175675675675676 2.04395687822654 0.000347970906575646 0.00785232460876364 GO:0001786 phosphatidylserine binding 14/1602 59/18639 0.23728813559322 2.76080746524472 0.000375593127168321 0.00827715098551885 GO:0046966 nuclear thyroid hormone receptor binding 9/1602 28/18639 0.321428571428571 3.73976725521669 0.00038285001791092 0.00827715098551885 GO:0019902 phosphatase binding 31/1602 190/18639 0.163157894736842 1.89831460674157 0.00038755890902095 0.00827715098551885 GO:0070123 transforming growth factor beta receptor activity, type III 6/1602 13/18639 0.461538461538462 5.36992221261884 0.00040328342773914 0.00846187683466686 GO:0019207 kinase regulator activity 42/1602 287/18639 0.146341463414634 1.70265826253768 0.000460403089652624 0.00943307907317669 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 7/1602 18/18639 0.388888888888889 4.52465667915106 0.000465344201770422 0.00943307907317669 GO:0044325 transmembrane transporter binding 24/1602 136/18639 0.176470588235294 2.05320555188367 0.000539183875537075 0.010747731919039 GO:0030165 PDZ domain binding 17/1602 83/18639 0.204819277108434 2.38303776905374 0.000599903054534771 0.0117050698526545 GO:0035035 histone acetyltransferase binding 8/1602 24/18639 0.333333333333333 3.87827715355805 0.000614328747665816 0.0117050698526545 GO:0042393 histone binding 37/1602 247/18639 0.149797570850202 1.7428694900605 0.000625621720152552 0.0117050698526545 GO:0098632 cell-cell adhesion mediator activity 13/1602 55/18639 0.236363636363636 2.75005107252298 0.000626358252984855 0.0117050698526545 GO:0005545 1-phosphatidylinositol binding 6/1602 14/18639 0.428571428571429 4.98635634028892 0.000654540317308781 0.0118610639318379 GO:0042043 neurexin family protein binding 6/1602 14/18639 0.428571428571429 4.98635634028892 0.000654540317308781 0.0118610639318379 GO:0035925 mRNA 3'-UTR AU-rich region binding 9/1602 30/18639 0.3 3.49044943820225 0.000677660808721278 0.0120967511526963 GO:0008201 heparin binding 28/1602 172/18639 0.162790697674419 1.89404233080742 0.000750508936988611 0.0132001277740938 GO:0005522 profilin binding 5/1602 10/18639 0.5 5.81741573033708 0.000812731497480274 0.0140873459563247 GO:0005539 glycosaminoglycan binding 36/1602 242/18639 0.148760330578512 1.73080137431516 0.000836596306091422 0.0140970693449305 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 36/1602 243/18639 0.148148148148148 1.72367873491469 0.000902766678131227 0.0140970693449305 GO:0005010 insulin-like growth factor receptor activity 12/1602 51/18639 0.235294117647059 2.73760740251157 0.00104674916328406 0.0140970693449305 GO:0004676 3-phosphoinositide-dependent protein kinase activity 36/1602 245/18639 0.146938775510204 1.70960788809906 0.00104902940777493 0.0140970693449305 GO:0004711 ribosomal protein S6 kinase activity 36/1602 245/18639 0.146938775510204 1.70960788809906 0.00104902940777493 0.0140970693449305 GO:0035175 histone H3S10 kinase activity 36/1602 245/18639 0.146938775510204 1.70960788809906 0.00104902940777493 0.0140970693449305 GO:0035979 histone H2AXS139 kinase activity 36/1602 245/18639 0.146938775510204 1.70960788809906 0.00104902940777493 0.0140970693449305 GO:0044022 histone H3S28 kinase activity 36/1602 245/18639 0.146938775510204 1.70960788809906 0.00104902940777493 0.0140970693449305 GO:0044023 histone H4S1 kinase activity 36/1602 245/18639 0.146938775510204 1.70960788809906 0.00104902940777493 0.0140970693449305 GO:0044024 histone H2AS1 kinase activity 36/1602 245/18639 0.146938775510204 1.70960788809906 0.00104902940777493 0.0140970693449305 GO:0044025 histone H2BS14 kinase activity 36/1602 245/18639 0.146938775510204 1.70960788809906 0.00104902940777493 0.0140970693449305 GO:0072354 histone H3T3 kinase activity 36/1602 245/18639 0.146938775510204 1.70960788809906 0.00104902940777493 0.0140970693449305 GO:0072371 histone H2AS121 kinase activity 36/1602 245/18639 0.146938775510204 1.70960788809906 0.00104902940777493 0.0140970693449305 GO:0072518 Rho-dependent protein serine/threonine kinase activity 36/1602 245/18639 0.146938775510204 1.70960788809906 0.00104902940777493 0.0140970693449305 GO:0140823 histone H2BS36 kinase activity 36/1602 245/18639 0.146938775510204 1.70960788809906 0.00104902940777493 0.0140970693449305 GO:0140855 histone H3S57 kinase activity 36/1602 245/18639 0.146938775510204 1.70960788809906 0.00104902940777493 0.0140970693449305 GO:0140995 histone H2A kinase activity 36/1602 245/18639 0.146938775510204 1.70960788809906 0.00104902940777493 0.0140970693449305 GO:0140997 histone H4 kinase activity 36/1602 245/18639 0.146938775510204 1.70960788809906 0.00104902940777493 0.0140970693449305 GO:0140998 histone H2B kinase activity 36/1602 245/18639 0.146938775510204 1.70960788809906 0.00104902940777493 0.0140970693449305 GO:1990244 histone H2AT120 kinase activity 36/1602 245/18639 0.146938775510204 1.70960788809906 0.00104902940777493 0.0140970693449305 GO:1901981 phosphatidylinositol phosphate binding 29/1602 185/18639 0.156756756756757 1.82383844518676 0.00112928053758681 0.0145727744559964 GO:0004677 DNA-dependent protein kinase activity 36/1602 246/18639 0.146341463414634 1.70265826253768 0.00112965490379102 0.0145727744559964 GO:0140857 histone H3T45 kinase activity 36/1602 246/18639 0.146341463414634 1.70265826253768 0.00112965490379102 0.0145727744559964 GO:0019887 protein kinase regulator activity 37/1602 255/18639 0.145098039215686 1.6881912315488 0.00113873065269773 0.0145727744559964 GO:0004842 ubiquitin-protein transferase activity 58/1602 449/18639 0.129175946547884 1.50294036685769 0.00114535183851476 0.0145727744559964 GO:0035402 histone H3T11 kinase activity 36/1602 247/18639 0.145748987854251 1.69576490924806 0.00121565108678147 0.0151449864561525 GO:0035403 histone H3T6 kinase activity 36/1602 247/18639 0.145748987854251 1.69576490924806 0.00121565108678147 0.0151449864561525 GO:0019787 ubiquitin-like protein transferase activity 61/1602 479/18639 0.127348643006263 1.48167999812343 0.00123245404424965 0.0151960313084802 GO:0045309 protein phosphorylated amino acid binding 13/1602 59/18639 0.220338983050847 2.56360693201295 0.00126527968662775 0.0154415765837427 GO:0005200 structural constituent of cytoskeleton 20/1602 112/18639 0.178571428571429 2.07764847512039 0.00129898965957377 0.0156354717494685 GO:0004679 AMP-activated protein kinase activity 36/1602 248/18639 0.145161290322581 1.68892714751722 0.00130731369142713 0.0156354717494685 GO:0051010 microtubule plus-end binding 7/1602 21/18639 0.333333333333333 3.87827715355805 0.001351392913316 0.0157732271514292 GO:0045294 alpha-catenin binding 5/1602 11/18639 0.454545454545455 5.28855975485189 0.00138477328670574 0.0157732271514292 GO:0048185 activin binding 5/1602 11/18639 0.454545454545455 5.28855975485189 0.00138477328670574 0.0157732271514292 GO:0048407 platelet-derived growth factor binding 5/1602 11/18639 0.454545454545455 5.28855975485189 0.00138477328670574 0.0157732271514292 GO:0097493 structural molecule activity conferring elasticity 5/1602 11/18639 0.454545454545455 5.28855975485189 0.00138477328670574 0.0157732271514292 GO:0070411 I-SMAD binding 6/1602 16/18639 0.375 4.36306179775281 0.00150198522543724 0.0169469276379523 GO:0030295 protein kinase activator activity 23/1602 139/18639 0.165467625899281 1.92518793953601 0.00171051564839391 0.018942376995177 GO:0070851 growth factor receptor binding 23/1602 139/18639 0.165467625899281 1.92518793953601 0.00171051564839391 0.018942376995177 GO:0140030 modification-dependent protein binding 27/1602 173/18639 0.15606936416185 1.8158407481977 0.00175248633005671 0.0189871689747364 GO:0001784 phosphotyrosine residue binding 11/1602 47/18639 0.234042553191489 2.72304566100885 0.00175363853927699 0.0189871689747364 GO:0061659 ubiquitin-like protein ligase activity 49/1602 372/18639 0.131720430107527 1.53254500422859 0.00177375860349828 0.0189871689747364 GO:0016755 aminoacyltransferase activity 62/1602 496/18639 0.125 1.45435393258427 0.00177841819149391 0.0189871689747364 GO:0035401 histone H3Y41 kinase activity 20/1602 115/18639 0.173913043478261 2.02344894968246 0.00180981376515046 0.0189871689747364 GO:0140801 histone H2AXY142 kinase activity 20/1602 115/18639 0.173913043478261 2.02344894968246 0.00180981376515046 0.0189871689747364 GO:0005025 transforming growth factor beta receptor activity, type I 5/1602 12/18639 0.416666666666667 4.84784644194757 0.00220663040529288 0.0216322128256581 GO:0005026 transforming growth factor beta receptor activity, type II 5/1602 12/18639 0.416666666666667 4.84784644194757 0.00220663040529288 0.0216322128256581 GO:0016361 activin receptor activity, type I 5/1602 12/18639 0.416666666666667 4.84784644194757 0.00220663040529288 0.0216322128256581 GO:0016362 activin receptor activity, type II 5/1602 12/18639 0.416666666666667 4.84784644194757 0.00220663040529288 0.0216322128256581 GO:0017002 activin receptor activity 5/1602 12/18639 0.416666666666667 4.84784644194757 0.00220663040529288 0.0216322128256581 GO:0035259 nuclear glucocorticoid receptor binding 5/1602 12/18639 0.416666666666667 4.84784644194757 0.00220663040529288 0.0216322128256581 GO:0035497 cAMP response element binding 5/1602 12/18639 0.416666666666667 4.84784644194757 0.00220663040529288 0.0216322128256581 GO:0070410 co-SMAD binding 5/1602 12/18639 0.416666666666667 4.84784644194757 0.00220663040529288 0.0216322128256581 GO:0035198 miRNA binding 10/1602 42/18639 0.238095238095238 2.77019796682718 0.00244653191335101 0.0237890420192505 GO:0001222 transcription corepressor binding 11/1602 49/18639 0.224489795918367 2.61190094015134 0.00250275180670367 0.0239463292865408 GO:0060590 ATPase regulator activity 11/1602 49/18639 0.224489795918367 2.61190094015134 0.00250275180670367 0.0239463292865408 GO:0048156 tau protein binding 10/1602 43/18639 0.232558139534884 2.70577475829632 0.00294658982129835 0.0279570432945792 GO:0061630 ubiquitin protein ligase activity 46/1602 353/18639 0.130311614730878 1.51615367476207 0.00296868269097957 0.0279570432945792 GO:0004970 glutamate-gated receptor activity 6/1602 18/18639 0.333333333333333 3.87827715355805 0.00299796013085858 0.0280121899727098 GO:0050431 transforming growth factor beta binding 7/1602 24/18639 0.291666666666667 3.3934925093633 0.00320045453278598 0.0296724311721863 GO:0140852 histone ubiquitin ligase activity 5/1602 13/18639 0.384615384615385 4.47493517718237 0.00333372226626396 0.0306702448496285 GO:0061980 regulatory RNA binding 12/1602 58/18639 0.206896551724138 2.407206509105 0.00336011644510847 0.0306770936515246 GO:0004715 non-membrane spanning protein tyrosine kinase activity 10/1602 45/18639 0.222222222222222 2.58551810237203 0.00418961960757986 0.0379604928080721 GO:0004714 transmembrane receptor protein tyrosine kinase activity 12/1602 60/18639 0.2 2.32696629213483 0.00449613107126567 0.0404313741446146 GO:0005085 guanyl-nucleotide exchange factor activity 32/1602 230/18639 0.139130434782609 1.61875915974597 0.00455576729757732 0.0406619230440483 GO:0070717 poly-purine tract binding 8/1602 32/18639 0.25 2.90870786516854 0.00473377989230619 0.0417920245803682 GO:0005548 phospholipid transporter activity 13/1602 68/18639 0.191176470588235 2.22430601454065 0.00476191871671714 0.0417920245803682 GO:0044548 S100 protein binding 5/1602 14/18639 0.357142857142857 4.15529695024077 0.00482215668235018 0.0417920245803682 GO:0098821 BMP receptor activity 5/1602 14/18639 0.357142857142857 4.15529695024077 0.00482215668235018 0.0417920245803682 GO:0008066 glutamate receptor activity 7/1602 26/18639 0.269230769230769 3.13245462402766 0.00522624462366219 0.0446470612135713 GO:0043548 phosphatidylinositol 3-kinase binding 7/1602 26/18639 0.269230769230769 3.13245462402766 0.00522624462366219 0.0446470612135713 GO:0140463 chromatin-protein adaptor activity 11/1602 54/18639 0.203703703703704 2.3700582605077 0.00553516168502321 0.0469507331580692 GO:0015631 tubulin binding 48/1602 385/18639 0.124675324675325 1.45057638990223 0.00577524812869098 0.0486422307177071 GO:0030331 nuclear estrogen receptor binding 9/1602 40/18639 0.225 2.61783707865169 0.00593217069362497 0.0492699732609407 GO:0140662 ATP-dependent protein folding chaperone 9/1602 40/18639 0.225 2.61783707865169 0.00593217069362497 0.0492699732609407 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 15/1602 86/18639 0.174418604651163 2.02933106872224 0.00622190462471948 0.0513199857321689 GO:0035613 RNA stem-loop binding 6/1602 21/18639 0.285714285714286 3.32423756019262 0.00700929438227368 0.0572237654597935 GO:0042169 SH2 domain binding 9/1602 41/18639 0.219512195121951 2.55398739380652 0.00703335578811843 0.0572237654597935 GO:1905394 retromer complex binding 4/1602 10/18639 0.4 4.65393258426966 0.00748142141705552 0.0597184005069432 GO:0005004 GPI-linked ephrin receptor activity 10/1602 49/18639 0.204081632653061 2.37445540013758 0.00788922013386039 0.0597184005069432 GO:0005008 hepatocyte growth factor receptor activity 10/1602 49/18639 0.204081632653061 2.37445540013758 0.00788922013386039 0.0597184005069432 GO:0005009 insulin receptor activity 10/1602 49/18639 0.204081632653061 2.37445540013758 0.00788922013386039 0.0597184005069432 GO:0005011 macrophage colony-stimulating factor receptor activity 10/1602 49/18639 0.204081632653061 2.37445540013758 0.00788922013386039 0.0597184005069432 GO:0005018 platelet-derived growth factor alpha-receptor activity 10/1602 49/18639 0.204081632653061 2.37445540013758 0.00788922013386039 0.0597184005069432 GO:0005020 stem cell factor receptor activity 10/1602 49/18639 0.204081632653061 2.37445540013758 0.00788922013386039 0.0597184005069432 GO:0008288 boss receptor activity 10/1602 49/18639 0.204081632653061 2.37445540013758 0.00788922013386039 0.0597184005069432 GO:0036332 placental growth factor receptor activity 10/1602 49/18639 0.204081632653061 2.37445540013758 0.00788922013386039 0.0597184005069432 GO:0038062 protein tyrosine kinase collagen receptor activity 10/1602 49/18639 0.204081632653061 2.37445540013758 0.00788922013386039 0.0597184005069432 GO:0060175 brain-derived neurotrophic factor receptor activity 10/1602 49/18639 0.204081632653061 2.37445540013758 0.00788922013386039 0.0597184005069432 GO:0046875 ephrin receptor binding 7/1602 28/18639 0.25 2.90870786516854 0.00808681992149936 0.0604489789132078 GO:0051019 mitogen-activated protein kinase binding 7/1602 28/18639 0.25 2.90870786516854 0.00808681992149936 0.0604489789132078 GO:0042056 chemoattractant activity 9/1602 42/18639 0.214285714285714 2.49317817014446 0.00828430775396411 0.0615405718865905 GO:0008093 cytoskeletal anchor activity 6/1602 22/18639 0.272727272727273 3.17313585291113 0.00894912677843461 0.0645451928204328 GO:0005521 lamin binding 5/1602 16/18639 0.3125 3.63588483146067 0.00910242679161885 0.0645451928204328 GO:0140327 flippase activity 5/1602 16/18639 0.3125 3.63588483146067 0.00910242679161885 0.0645451928204328 GO:0140328 floppase activity 5/1602 16/18639 0.3125 3.63588483146067 0.00910242679161885 0.0645451928204328 GO:0005006 epidermal growth factor receptor activity 10/1602 50/18639 0.2 2.32696629213483 0.00912051637680028 0.0645451928204328 GO:0005007 fibroblast growth factor receptor activity 10/1602 50/18639 0.2 2.32696629213483 0.00912051637680028 0.0645451928204328 GO:0005017 platelet-derived growth factor receptor activity 10/1602 50/18639 0.2 2.32696629213483 0.00912051637680028 0.0645451928204328 GO:0005019 platelet-derived growth factor beta-receptor activity 10/1602 50/18639 0.2 2.32696629213483 0.00912051637680028 0.0645451928204328 GO:0004712 protein serine/threonine/tyrosine kinase activity 9/1602 43/18639 0.209302325581395 2.43519728246668 0.00969723308908152 0.0682228869090676 GO:0106222 lncRNA binding 7/1602 29/18639 0.241379310344828 2.80840759395583 0.00988546497631523 0.069140445097503 GO:0072341 modified amino acid binding 15/1602 91/18639 0.164835164835165 1.91782936164959 0.0104745792395023 0.0721277267634533 GO:0005021 vascular endothelial growth factor receptor activity 10/1602 51/18639 0.196078431372549 2.28133950209297 0.0104934987097332 0.0721277267634533 GO:0005030 neurotrophin receptor activity 10/1602 51/18639 0.196078431372549 2.28133950209297 0.0104934987097332 0.0721277267634533 GO:0034713 type I transforming growth factor beta receptor binding 4/1602 11/18639 0.363636363636364 4.23084780388151 0.010965220348684 0.0749394487830059 GO:0019903 protein phosphatase binding 21/1602 144/18639 0.145833333333333 1.69674625468165 0.0115293607410209 0.0783472468537559 GO:0008187 poly-pyrimidine tract binding 7/1602 30/18639 0.233333333333333 2.71479400749064 0.0119589514670357 0.0806138051014244 GO:0046965 nuclear retinoid X receptor binding 5/1602 17/18639 0.294117647058824 3.42200925313946 0.011997706779309 0.0806138051014244 GO:0098631 cell adhesion mediator activity 13/1602 76/18639 0.171052631578947 1.99016853932584 0.0122512174434105 0.0814025336795498 GO:0140034 methylation-dependent protein binding 13/1602 76/18639 0.171052631578947 1.99016853932584 0.0122512174434105 0.0814025336795498 GO:0003713 transcription coactivator activity 33/1602 256/18639 0.12890625 1.49980249297753 0.0123959327516325 0.0815323620649721 GO:0032934 sterol binding 12/1602 68/18639 0.176470588235294 2.05320555188367 0.0124070985751045 0.0815323620649721 GO:0004222 metalloendopeptidase activity 17/1602 110/18639 0.154545454545455 1.79811031664964 0.0126091041519203 0.0824070413426051 GO:0005003 ephrin receptor activity 10/1602 53/18639 0.188679245283019 2.19525121899512 0.0137034715050424 0.0867446767042535 GO:0005005 transmembrane-ephrin receptor activity 10/1602 53/18639 0.188679245283019 2.19525121899512 0.0137034715050424 0.0867446767042535 GO:0038064 collagen receptor activity 10/1602 53/18639 0.188679245283019 2.19525121899512 0.0137034715050424 0.0867446767042535 GO:0051018 protein kinase A binding 10/1602 53/18639 0.188679245283019 2.19525121899512 0.0137034715050424 0.0867446767042535 GO:1902936 phosphatidylinositol bisphosphate binding 17/1602 111/18639 0.153153153153153 1.78191112460775 0.0137340626702181 0.0867446767042535 GO:0002039 p53 binding 12/1602 69/18639 0.173913043478261 2.02344894968246 0.0138788079938674 0.0867446767042535 GO:0050699 WW domain binding 6/1602 24/18639 0.25 2.90870786516854 0.0139255668287765 0.0867446767042535 GO:0070840 dynein complex binding 6/1602 24/18639 0.25 2.90870786516854 0.0139255668287765 0.0867446767042535 GO:0140033 acetylation-dependent protein binding 6/1602 24/18639 0.25 2.90870786516854 0.0139255668287765 0.0867446767042535 GO:0005078 MAP-kinase scaffold activity 4/1602 12/18639 0.333333333333333 3.87827715355805 0.0153445153203795 0.0929102551072398 GO:0005165 neurotrophin receptor binding 4/1602 12/18639 0.333333333333333 3.87827715355805 0.0153445153203795 0.0929102551072398 GO:0017166 vinculin binding 4/1602 12/18639 0.333333333333333 3.87827715355805 0.0153445153203795 0.0929102551072398 GO:0035014 phosphatidylinositol 3-kinase regulator activity 4/1602 12/18639 0.333333333333333 3.87827715355805 0.0153445153203795 0.0929102551072398 GO:0045295 gamma-catenin binding 4/1602 12/18639 0.333333333333333 3.87827715355805 0.0153445153203795 0.0929102551072398 GO:0070064 proline-rich region binding 5/1602 18/18639 0.277777777777778 3.23189762796504 0.0154591477979437 0.0929102551072398 GO:0098641 cadherin binding involved in cell-cell adhesion 5/1602 18/18639 0.277777777777778 3.23189762796504 0.0154591477979437 0.0929102551072398 GO:0015485 cholesterol binding 10/1602 54/18639 0.185185185185185 2.15459841864336 0.0155599055550468 0.0930482352191797 GO:0042974 nuclear retinoic acid receptor binding 6/1602 25/18639 0.24 2.7923595505618 0.017022062628691 0.101285506984649 GO:0140938 histone H3 methyltransferase activity 9/1602 47/18639 0.191489361702128 2.22794644991633 0.0172135561958859 0.101917887179602 GO:0003727 single-stranded RNA binding 14/1602 89/18639 0.157303370786517 1.83019820729706 0.0192919056135705 0.113660685289805 GO:0042800 histone H3K4 methyltransferase activity 5/1602 19/18639 0.263157894736842 3.06179775280899 0.0195278885216362 0.114487032705279 GO:0030296 protein tyrosine kinase activator activity 7/1602 33/18639 0.212121212121212 2.46799455226422 0.0200383286670999 0.116133540364869 GO:1901681 sulfur compound binding 34/1602 275/18639 0.123636363636364 1.43848825331971 0.0200963659933402 0.116133540364869 GO:0008143 poly(A) binding 6/1602 26/18639 0.230769230769231 2.68496110630942 0.0205608080301997 0.116133540364869 GO:0050750 low-density lipoprotein particle receptor binding 6/1602 26/18639 0.230769230769231 2.68496110630942 0.0205608080301997 0.116133540364869 GO:0043560 insulin receptor substrate binding 4/1602 13/18639 0.307692307692308 3.57994814174589 0.0206826455666531 0.116133540364869 GO:0046975 histone H3K36 methyltransferase activity 4/1602 13/18639 0.307692307692308 3.57994814174589 0.0206826455666531 0.116133540364869 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 4/1602 13/18639 0.307692307692308 3.57994814174589 0.0206826455666531 0.116133540364869 GO:0140333 glycerophospholipid flippase activity 4/1602 13/18639 0.307692307692308 3.57994814174589 0.0206826455666531 0.116133540364869 GO:0140666 annealing activity 4/1602 13/18639 0.307692307692308 3.57994814174589 0.0206826455666531 0.116133540364869 GO:0008017 microtubule binding 34/1602 276/18639 0.123188405797101 1.43327633935841 0.0210920534163375 0.117878952738036 GO:1990782 protein tyrosine kinase binding 17/1602 117/18639 0.145299145299145 1.69053106693556 0.0222183957504896 0.123596285198072 GO:0016887 ATP hydrolysis activity 48/1602 417/18639 0.115107913669065 1.3392611753294 0.0230168518638853 0.127445161246328 GO:0005104 fibroblast growth factor receptor binding 6/1602 27/18639 0.222222222222222 2.58551810237203 0.0245664302986457 0.134161875055618 GO:0008266 poly(U) RNA binding 6/1602 27/18639 0.222222222222222 2.58551810237203 0.0245664302986457 0.134161875055618 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 6/1602 27/18639 0.222222222222222 2.58551810237203 0.0245664302986457 0.134161875055618 GO:0051117 ATPase binding 13/1602 84/18639 0.154761904761905 1.80062867843767 0.0266454546343133 0.144304026696284 GO:0042054 histone methyltransferase activity 11/1602 67/18639 0.164179104477612 1.91019620996143 0.0268067879131392 0.144304026696284 GO:0005161 platelet-derived growth factor receptor binding 4/1602 14/18639 0.285714285714286 3.32423756019262 0.0270268411203742 0.144304026696284 GO:0008559 ABC-type xenobiotic transporter activity 4/1602 14/18639 0.285714285714286 3.32423756019262 0.0270268411203742 0.144304026696284 GO:1990825 sequence-specific mRNA binding 4/1602 14/18639 0.285714285714286 3.32423756019262 0.0270268411203742 0.144304026696284 GO:0017022 myosin binding 12/1602 76/18639 0.157894736842105 1.83707865168539 0.0281648529443996 0.149711840540009 GO:0141052 histone H3 demethylase activity 6/1602 28/18639 0.214285714285714 2.49317817014446 0.0290608694924128 0.153791150057194 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 5/1602 21/18639 0.238095238095238 2.77019796682718 0.0296240718097778 0.154717859757617 GO:0010314 phosphatidylinositol-5-phosphate binding 5/1602 21/18639 0.238095238095238 2.77019796682718 0.0296240718097778 0.154717859757617 GO:0036122 BMP binding 5/1602 21/18639 0.238095238095238 2.77019796682718 0.0296240718097778 0.154717859757617 GO:0098531 ligand-modulated transcription factor activity 10/1602 60/18639 0.166666666666667 1.93913857677903 0.0308095220735058 0.16020951478223 GO:0030159 signaling receptor complex adaptor activity 9/1602 52/18639 0.173076923076923 2.01372082973207 0.0316849951894254 0.164048719682047 GO:0004867 serine-type endopeptidase inhibitor activity 14/1602 95/18639 0.147368421052632 1.71460674157303 0.0320941600879575 0.164740838906426 GO:0008276 protein methyltransferase activity 14/1602 95/18639 0.147368421052632 1.71460674157303 0.0320941600879575 0.164740838906426 GO:0016279 protein-lysine N-methyltransferase activity 11/1602 69/18639 0.159420289855072 1.85482820387559 0.0325645639618239 0.166441104693766 GO:0005523 tropomyosin binding 4/1602 15/18639 0.266666666666667 3.10262172284644 0.034408496508806 0.174375261968356 GO:0120283 protein serine/threonine kinase binding 4/1602 15/18639 0.266666666666667 3.10262172284644 0.034408496508806 0.174375261968356 GO:0016278 lysine N-methyltransferase activity 11/1602 70/18639 0.157142857142857 1.82833065810594 0.03574987283104 0.180130063391311 GO:0043394 proteoglycan binding 7/1602 37/18639 0.189189189189189 2.20118433039781 0.0358452801731873 0.180130063391311 GO:0140303 intramembrane lipid transporter activity 8/1602 45/18639 0.177777777777778 2.06841448189763 0.0360659880507558 0.180480843969473 GO:0003925 G protein activity 9/1602 54/18639 0.166666666666667 1.93913857677903 0.0393236598388315 0.19596290486351 GO:0032452 histone demethylase activity 6/1602 30/18639 0.2 2.32696629213483 0.0395891982974846 0.196467556696231 GO:0019955 cytokine binding 19/1602 144/18639 0.131944444444444 1.5351513732834 0.0398617127644665 0.196906248246078 GO:0048306 calcium-dependent protein binding 12/1602 80/18639 0.15 1.74522471910112 0.0400068715081914 0.196906248246078 GO:0005158 insulin receptor binding 5/1602 23/18639 0.217391304347826 2.52931118710308 0.042499562784547 0.204964993140469 GO:0044013 histone H2B acetyltransferase activity 5/1602 23/18639 0.217391304347826 2.52931118710308 0.042499562784547 0.204964993140469 GO:0070577 lysine-acetylated histone binding 5/1602 23/18639 0.217391304347826 2.52931118710308 0.042499562784547 0.204964993140469 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 4/1602 16/18639 0.25 2.90870786516854 0.0428438530812016 0.204964993140469 GO:0008142 oxysterol binding 4/1602 16/18639 0.25 2.90870786516854 0.0428438530812016 0.204964993140469 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 4/1602 16/18639 0.25 2.90870786516854 0.0428438530812016 0.204964993140469 GO:0034450 ubiquitin-ubiquitin ligase activity 4/1602 16/18639 0.25 2.90870786516854 0.0428438530812016 0.204964993140469 GO:0005496 steroid binding 15/1602 108/18639 0.138888888888889 1.61594881398252 0.0430893468232727 0.205318162552327 GO:0030971 receptor tyrosine kinase binding 12/1602 81/18639 0.148148148148148 1.72367873491469 0.0434416068012144 0.205359169081648 GO:0140313 molecular sequestering activity 9/1602 55/18639 0.163636363636364 1.90388151174668 0.0435745674374215 0.205359169081648 GO:0004386 helicase activity 20/1602 155/18639 0.129032258064516 1.50126857557086 0.0436130676812196 0.205359169081648 GO:0017147 Wnt-protein binding 6/1602 31/18639 0.193548387096774 2.25190286335629 0.0456517279035001 0.211625839428629 GO:0070273 phosphatidylinositol-4-phosphate binding 6/1602 31/18639 0.193548387096774 2.25190286335629 0.0456517279035001 0.211625839428629 GO:0070325 lipoprotein particle receptor binding 6/1602 31/18639 0.193548387096774 2.25190286335629 0.0456517279035001 0.211625839428629 GO:0140457 protein demethylase activity 6/1602 31/18639 0.193548387096774 2.25190286335629 0.0456517279035001 0.211625839428629 GO:0043539 protein serine/threonine kinase activator activity 11/1602 73/18639 0.150684931506849 1.75319378174542 0.0466029242210919 0.215201148140641 GO:0003680 minor groove of adenine-thymine-rich DNA binding 3/1602 10/18639 0.3 3.49044943820225 0.0480690951489544 0.215320740817039 GO:0004955 prostaglandin receptor activity 3/1602 10/18639 0.3 3.49044943820225 0.0480690951489544 0.215320740817039 GO:0016303 1-phosphatidylinositol-3-kinase activity 3/1602 10/18639 0.3 3.49044943820225 0.0480690951489544 0.215320740817039 GO:0032395 MHC class II receptor activity 3/1602 10/18639 0.3 3.49044943820225 0.0480690951489544 0.215320740817039 GO:0035256 G protein-coupled glutamate receptor binding 3/1602 10/18639 0.3 3.49044943820225 0.0480690951489544 0.215320740817039 GO:0043121 neurotrophin binding 3/1602 10/18639 0.3 3.49044943820225 0.0480690951489544 0.215320740817039 GO:0070097 delta-catenin binding 3/1602 10/18639 0.3 3.49044943820225 0.0480690951489544 0.215320740817039 GO:0140999 histone H3K4 trimethyltransferase activity 3/1602 10/18639 0.3 3.49044943820225 0.0480690951489544 0.215320740817039 GO:0005126 cytokine receptor binding 32/1602 275/18639 0.116363636363636 1.35387129724208 0.0486800992970573 0.217244025221196 GO:0038024 cargo receptor activity 10/1602 65/18639 0.153846153846154 1.78997407087295 0.0498158259345834 0.220523347620218 GO:0001091 RNA polymerase II general transcription initiation factor binding 5/1602 24/18639 0.208333333333333 2.42392322097378 0.0500190354044867 0.220523347620218 GO:0070300 phosphatidic acid binding 5/1602 24/18639 0.208333333333333 2.42392322097378 0.0500190354044867 0.220523347620218 GO:0140693 molecular condensate scaffold activity 8/1602 48/18639 0.166666666666667 1.93913857677903 0.0504003111190046 0.220523347620218 GO:0043021 ribonucleoprotein complex binding 22/1602 177/18639 0.124293785310734 1.44613724369961 0.0506492835956279 0.220523347620218 GO:0035064 methylated histone binding 11/1602 74/18639 0.148648648648649 1.729501973884 0.0506704364940078 0.220523347620218 GO:0043178 alcohol binding 13/1602 92/18639 0.141304347826087 1.644052271617 0.0507056192270569 0.220523347620218 GO:0043425 bHLH transcription factor binding 6/1602 32/18639 0.1875 2.1815308988764 0.0522601518307267 0.222749573395778 GO:0051059 NF-kappaB binding 6/1602 32/18639 0.1875 2.1815308988764 0.0522601518307267 0.222749573395778 GO:0005516 calmodulin binding 25/1602 207/18639 0.120772946859903 1.40517288172393 0.0523012354746324 0.222749573395778 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 4/1602 17/18639 0.235294117647059 2.73760740251157 0.0523349750202455 0.222749573395778 GO:0008484 sulfuric ester hydrolase activity 4/1602 17/18639 0.235294117647059 2.73760740251157 0.0523349750202455 0.222749573395778 GO:0019198 transmembrane receptor protein phosphatase activity 4/1602 17/18639 0.235294117647059 2.73760740251157 0.0523349750202455 0.222749573395778 GO:0044183 protein folding chaperone 11/1602 75/18639 0.146666666666667 1.70644194756554 0.0549704504195017 0.233137087594766 GO:0017080 sodium channel regulator activity 7/1602 41/18639 0.170731707317073 1.9864346396273 0.0582405539176138 0.244522320013084 GO:0004709 MAP kinase kinase kinase activity 5/1602 25/18639 0.2 2.32696629213483 0.0582682785984356 0.244522320013084 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 5/1602 25/18639 0.2 2.32696629213483 0.0582682785984356 0.244522320013084 GO:0016500 protein-hormone receptor activity 10/1602 67/18639 0.149253731343284 1.73654200905584 0.0592248137247165 0.246760368562244 GO:0071889 14-3-3 protein binding 6/1602 33/18639 0.181818181818182 2.11542390194076 0.0594205569781992 0.246760368562244 GO:0140311 protein sequestering activity 6/1602 33/18639 0.181818181818182 2.11542390194076 0.0594205569781992 0.246760368562244 GO:0002162 dystroglycan binding 3/1602 11/18639 0.272727272727273 3.17313585291113 0.0619830481990557 0.248764180020371 GO:0004954 prostanoid receptor activity 3/1602 11/18639 0.272727272727273 3.17313585291113 0.0619830481990557 0.248764180020371 GO:0005114 type II transforming growth factor beta receptor binding 3/1602 11/18639 0.272727272727273 3.17313585291113 0.0619830481990557 0.248764180020371 GO:0008046 axon guidance receptor activity 3/1602 11/18639 0.272727272727273 3.17313585291113 0.0619830481990557 0.248764180020371 GO:0008432 JUN kinase binding 3/1602 11/18639 0.272727272727273 3.17313585291113 0.0619830481990557 0.248764180020371 GO:0010854 adenylate cyclase regulator activity 3/1602 11/18639 0.272727272727273 3.17313585291113 0.0619830481990557 0.248764180020371 GO:0019215 intermediate filament binding 3/1602 11/18639 0.272727272727273 3.17313585291113 0.0619830481990557 0.248764180020371 GO:0034056 estrogen response element binding 3/1602 11/18639 0.272727272727273 3.17313585291113 0.0619830481990557 0.248764180020371 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 3/1602 11/18639 0.272727272727273 3.17313585291113 0.0619830481990557 0.248764180020371 GO:0047676 arachidonate-CoA ligase activity 3/1602 11/18639 0.272727272727273 3.17313585291113 0.0619830481990557 0.248764180020371 GO:0031690 adrenergic receptor binding 4/1602 18/18639 0.222222222222222 2.58551810237203 0.0628709256551889 0.251483702620755 GO:0004879 nuclear receptor activity 9/1602 59/18639 0.152542372881356 1.77480479908589 0.0636051805323112 0.252730218992173 GO:0070063 RNA polymerase binding 9/1602 59/18639 0.152542372881356 1.77480479908589 0.0636051805323112 0.252730218992173 GO:0008376 acetylgalactosaminyltransferase activity 6/1602 34/18639 0.176470588235294 2.05320555188367 0.067135714572199 0.263693483103257 GO:0030507 spectrin binding 5/1602 26/18639 0.192307692307692 2.23746758859118 0.0672462477813489 0.263693483103257 GO:0034237 protein kinase A regulatory subunit binding 5/1602 26/18639 0.192307692307692 2.23746758859118 0.0672462477813489 0.263693483103257 GO:0052742 phosphatidylinositol kinase activity 5/1602 26/18639 0.192307692307692 2.23746758859118 0.0672462477813489 0.263693483103257 GO:0001098 basal transcription machinery binding 9/1602 60/18639 0.15 1.74522471910112 0.0693926496721004 0.27033748862486 GO:0001099 basal RNA polymerase II transcription machinery binding 9/1602 60/18639 0.15 1.74522471910112 0.0693926496721004 0.27033748862486 GO:0008200 ion channel inhibitor activity 7/1602 43/18639 0.162790697674419 1.89404233080742 0.0720751656232284 0.279876292485004 GO:0004721 phosphoprotein phosphatase activity 21/1602 175/18639 0.12 1.3961797752809 0.0743812498234103 0.284042931818173 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 4/1602 19/18639 0.210526315789474 2.44943820224719 0.0744290688908029 0.284042931818173 GO:0042577 lipid phosphatase activity 4/1602 19/18639 0.210526315789474 2.44943820224719 0.0744290688908029 0.284042931818173 GO:0046624 sphingolipid transporter activity 4/1602 19/18639 0.210526315789474 2.44943820224719 0.0744290688908029 0.284042931818173 GO:1990380 K48-linked deubiquitinase activity 4/1602 19/18639 0.210526315789474 2.44943820224719 0.0744290688908029 0.284042931818173 GO:0005080 protein kinase C binding 8/1602 52/18639 0.153846153846154 1.78997407087295 0.0745731443067779 0.284042931818173 GO:0140789 histone phosphatase activity 17/1602 136/18639 0.125 1.45435393258427 0.0751725504435566 0.285307551037035 GO:0140566 histone reader activity 6/1602 35/18639 0.171428571428571 1.99454253611557 0.0754051303346571 0.285307551037035 GO:0019208 phosphatase regulator activity 15/1602 117/18639 0.128205128205128 1.49164505906079 0.0763791397619972 0.285307551037035 GO:0004725 protein tyrosine phosphatase activity 13/1602 98/18639 0.13265306122449 1.54339601008943 0.0764319343429799 0.285307551037035 GO:0008170 N-methyltransferase activity 13/1602 98/18639 0.13265306122449 1.54339601008943 0.0764319343429799 0.285307551037035 GO:0001664 G protein-coupled receptor binding 33/1602 297/18639 0.111111111111111 1.29275905118602 0.0765302406038985 0.285307551037035 GO:0001671 ATPase activator activity 5/1602 27/18639 0.185185185185185 2.15459841864336 0.0769462063001451 0.285307551037035 GO:0023026 MHC class II protein complex binding 5/1602 27/18639 0.185185185185185 2.15459841864336 0.0769462063001451 0.285307551037035 GO:0005095 GTPase inhibitor activity 3/1602 12/18639 0.25 2.90870786516854 0.0775292258252813 0.285307551037035 GO:0008179 adenylate cyclase binding 3/1602 12/18639 0.25 2.90870786516854 0.0775292258252813 0.285307551037035 GO:0035197 siRNA binding 3/1602 12/18639 0.25 2.90870786516854 0.0775292258252813 0.285307551037035 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 12/1602 89/18639 0.134831460674157 1.56874132054034 0.0783942637317247 0.286726420254259 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 12/1602 89/18639 0.134831460674157 1.56874132054034 0.0783942637317247 0.286726420254259 GO:0001046 core promoter sequence-specific DNA binding 7/1602 44/18639 0.159090909090909 1.85099591419816 0.0796615513066567 0.289590320251554 GO:0016248 channel inhibitor activity 7/1602 44/18639 0.159090909090909 1.85099591419816 0.0796615513066567 0.289590320251554 GO:0140296 general transcription initiation factor binding 8/1602 53/18639 0.150943396226415 1.7562009751961 0.0815438305613397 0.295534610155643 GO:0140793 histone H2AXY142 phosphatase activity 12/1602 90/18639 0.133333333333333 1.55131086142322 0.0837395575021036 0.302575561246272 GO:0045505 dynein intermediate chain binding 6/1602 36/18639 0.166666666666667 1.93913857677903 0.0842251292866321 0.303413417550639 GO:0003924 GTPase activity 36/1602 331/18639 0.108761329305136 1.26541973590414 0.0847377193341746 0.30434328025127 GO:0005319 lipid transporter activity 21/1602 178/18639 0.117977528089888 1.37264865547279 0.0854044451418026 0.30549079036545 GO:0001618 virus receptor activity 11/1602 81/18639 0.135802469135802 1.58003884033847 0.0858293922426541 0.30549079036545 GO:0004175 endopeptidase activity 43/1602 405/18639 0.106172839506173 1.23530309335553 0.0869028361127359 0.30549079036545 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 4/1602 20/18639 0.2 2.32696629213483 0.0869764358650773 0.30549079036545 GO:0043024 ribosomal small subunit binding 4/1602 20/18639 0.2 2.32696629213483 0.0869764358650773 0.30549079036545 GO:0140939 histone H4 methyltransferase activity 4/1602 20/18639 0.2 2.32696629213483 0.0869764358650773 0.30549079036545 GO:0045499 chemorepellent activity 5/1602 28/18639 0.178571428571429 2.07764847512039 0.087356062127913 0.30549079036545 GO:0051393 alpha-actinin binding 5/1602 28/18639 0.178571428571429 2.07764847512039 0.087356062127913 0.30549079036545 GO:0051959 dynein light intermediate chain binding 5/1602 28/18639 0.178571428571429 2.07764847512039 0.087356062127913 0.30549079036545 GO:0141110 transporter inhibitor activity 7/1602 45/18639 0.155555555555556 1.80986267166042 0.0876923129590595 0.305772613116721 GO:0140272 exogenous protein binding 11/1602 82/18639 0.134146341463415 1.56077007399287 0.0918335065697459 0.319281610050628 GO:0042805 actinin binding 6/1602 37/18639 0.162162162162162 1.88672942605527 0.0935889710505245 0.324441766308485 GO:0005172 vascular endothelial growth factor receptor binding 3/1602 13/18639 0.230769230769231 2.68496110630942 0.0945831999028697 0.325061801965035 GO:0046974 histone H3K9 methyltransferase activity 3/1602 13/18639 0.230769230769231 2.68496110630942 0.0945831999028697 0.325061801965035 GO:0051011 microtubule minus-end binding 3/1602 13/18639 0.230769230769231 2.68496110630942 0.0945831999028697 0.325061801965035 GO:0003697 single-stranded DNA binding 15/1602 121/18639 0.12396694214876 1.44233447859597 0.0954538326806475 0.327113993942849 GO:0016791 phosphatase activity 30/1602 273/18639 0.10989010989011 1.27855290776639 0.0975752964910074 0.333428727437843 GO:0051861 glycolipid binding 5/1602 29/18639 0.172413793103448 2.00600542425417 0.0984587523771875 0.334535988190671 GO:0099604 ligand-gated calcium channel activity 5/1602 29/18639 0.172413793103448 2.00600542425417 0.0984587523771875 0.334535988190671 GO:0005109 frizzled binding 6/1602 38/18639 0.157894736842105 1.83707865168539 0.10348699149584 0.350624481102051 GO:0043495 protein-membrane adaptor activity 7/1602 47/18639 0.148936170212766 1.73284723882381 0.105070096394861 0.353982634614798 GO:0140359 ABC-type transporter activity 7/1602 47/18639 0.148936170212766 1.73284723882381 0.105070096394861 0.353982634614798 GO:0019003 GDP binding 10/1602 75/18639 0.133333333333333 1.55131086142322 0.107867727447002 0.362387084344423 GO:0051721 protein phosphatase 2A binding 5/1602 30/18639 0.166666666666667 1.93913857677903 0.110232663193128 0.363071713656582 GO:0004705 JUN kinase activity 3/1602 14/18639 0.214285714285714 2.49317817014446 0.113007661389005 0.363071713656582 GO:0008195 phosphatidate phosphatase activity 3/1602 14/18639 0.214285714285714 2.49317817014446 0.113007661389005 0.363071713656582 GO:0032454 histone H3K9 demethylase activity 3/1602 14/18639 0.214285714285714 2.49317817014446 0.113007661389005 0.363071713656582 GO:0042813 Wnt receptor activity 3/1602 14/18639 0.214285714285714 2.49317817014446 0.113007661389005 0.363071713656582 GO:0061665 SUMO ligase activity 3/1602 14/18639 0.214285714285714 2.49317817014446 0.113007661389005 0.363071713656582 GO:0070742 C2H2 zinc finger domain binding 3/1602 14/18639 0.214285714285714 2.49317817014446 0.113007661389005 0.363071713656582 GO:0030021 extracellular matrix structural constituent conferring compression resistance 4/1602 22/18639 0.181818181818182 2.11542390194076 0.114863592374881 0.363071713656582 GO:0031683 G-protein beta/gamma-subunit complex binding 4/1602 22/18639 0.181818181818182 2.11542390194076 0.114863592374881 0.363071713656582 GO:0032931 histone H3K56 acetyltransferase activity 4/1602 22/18639 0.181818181818182 2.11542390194076 0.114863592374881 0.363071713656582 GO:0043992 histone H3K9 acetyltransferase activity 4/1602 22/18639 0.181818181818182 2.11542390194076 0.114863592374881 0.363071713656582 GO:0043993 histone H3K18 acetyltransferase activity 4/1602 22/18639 0.181818181818182 2.11542390194076 0.114863592374881 0.363071713656582 GO:0043994 histone H3K23 acetyltransferase activity 4/1602 22/18639 0.181818181818182 2.11542390194076 0.114863592374881 0.363071713656582 GO:0043999 histone H2AK5 acetyltransferase activity 4/1602 22/18639 0.181818181818182 2.11542390194076 0.114863592374881 0.363071713656582 GO:0044012 histone H2AK9 acetyltransferase activity 4/1602 22/18639 0.181818181818182 2.11542390194076 0.114863592374881 0.363071713656582 GO:0044014 histone H2BK5 acetyltransferase activity 4/1602 22/18639 0.181818181818182 2.11542390194076 0.114863592374881 0.363071713656582 GO:0044015 histone H2BK12 acetyltransferase activity 4/1602 22/18639 0.181818181818182 2.11542390194076 0.114863592374881 0.363071713656582 GO:0044016 histone H3K4 acetyltransferase activity 4/1602 22/18639 0.181818181818182 2.11542390194076 0.114863592374881 0.363071713656582 GO:0044017 histone H3K27 acetyltransferase activity 4/1602 22/18639 0.181818181818182 2.11542390194076 0.114863592374881 0.363071713656582 GO:0044018 histone H3K36 acetyltransferase activity 4/1602 22/18639 0.181818181818182 2.11542390194076 0.114863592374881 0.363071713656582 GO:0046972 histone H4K16 acetyltransferase activity 4/1602 22/18639 0.181818181818182 2.11542390194076 0.114863592374881 0.363071713656582 GO:0140908 histone H3K122 acetyltransferase activity 4/1602 22/18639 0.181818181818182 2.11542390194076 0.114863592374881 0.363071713656582 GO:0061134 peptidase regulator activity 25/1602 226/18639 0.110619469026549 1.28703887839316 0.115053661769101 0.363071713656582 GO:0050840 extracellular matrix binding 9/1602 67/18639 0.134328358208955 1.56288780815026 0.118802067472859 0.37391387551984 GO:0002020 protease binding 16/1602 136/18639 0.117647058823529 1.36880370125578 0.123145889103745 0.38656819781648 GO:0035254 glutamate receptor binding 7/1602 49/18639 0.142857142857143 1.66211878009631 0.124156046993605 0.388718932472125 GO:0042277 peptide binding 27/1602 249/18639 0.108433734939759 1.26160823067551 0.124561609625001 0.388803699368114 GO:0032451 demethylase activity 6/1602 40/18639 0.15 1.74522471910112 0.124833294780398 0.388803699368114 GO:0030145 manganese ion binding 9/1602 68/18639 0.132352941176471 1.53990416391276 0.127110601663665 0.394868258674658 GO:0019888 protein phosphatase regulator activity 13/1602 107/18639 0.121495327102804 1.4135776541006 0.12847842464618 0.396645783301073 GO:0017134 fibroblast growth factor binding 4/1602 23/18639 0.173913043478261 2.02344894968246 0.130098124920214 0.396645783301073 GO:0070888 E-box binding 8/1602 59/18639 0.135593220338983 1.57760426585412 0.131065140769001 0.396645783301073 GO:0000774 adenyl-nucleotide exchange factor activity 3/1602 15/18639 0.2 2.32696629213483 0.132657452609054 0.396645783301073 GO:0004467 long-chain fatty acid-CoA ligase activity 3/1602 15/18639 0.2 2.32696629213483 0.132657452609054 0.396645783301073 GO:0004559 alpha-mannosidase activity 3/1602 15/18639 0.2 2.32696629213483 0.132657452609054 0.396645783301073 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 3/1602 15/18639 0.2 2.32696629213483 0.132657452609054 0.396645783301073 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 3/1602 15/18639 0.2 2.32696629213483 0.132657452609054 0.396645783301073 GO:0004953 icosanoid receptor activity 3/1602 15/18639 0.2 2.32696629213483 0.132657452609054 0.396645783301073 GO:0033130 acetylcholine receptor binding 3/1602 15/18639 0.2 2.32696629213483 0.132657452609054 0.396645783301073 GO:0042809 nuclear vitamin D receptor binding 3/1602 15/18639 0.2 2.32696629213483 0.132657452609054 0.396645783301073 GO:0048531 beta-1,3-galactosyltransferase activity 3/1602 15/18639 0.2 2.32696629213483 0.132657452609054 0.396645783301073 GO:0051371 muscle alpha-actinin binding 3/1602 15/18639 0.2 2.32696629213483 0.132657452609054 0.396645783301073 GO:0061578 K63-linked deubiquitinase activity 3/1602 15/18639 0.2 2.32696629213483 0.132657452609054 0.396645783301073 GO:0140776 protein-containing complex destabilizing activity 3/1602 15/18639 0.2 2.32696629213483 0.132657452609054 0.396645783301073 GO:0042910 xenobiotic transmembrane transporter activity 5/1602 32/18639 0.15625 1.81794241573034 0.135687614935938 0.404694233075766 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 6/1602 41/18639 0.146341463414634 1.70265826253768 0.136249193214018 0.40535829622877 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 8/1602 60/18639 0.133333333333333 1.55131086142322 0.14055321632237 0.417125674247034 GO:0099106 ion channel regulator activity 18/1602 160/18639 0.1125 1.30891853932584 0.144660593397179 0.428252647779768 GO:0005540 hyaluronic acid binding 4/1602 24/18639 0.166666666666667 1.93913857677903 0.14611394282336 0.428314401021417 GO:0030215 semaphorin receptor binding 4/1602 24/18639 0.166666666666667 1.93913857677903 0.14611394282336 0.428314401021417 GO:0043998 histone H2A acetyltransferase activity 4/1602 24/18639 0.166666666666667 1.93913857677903 0.14611394282336 0.428314401021417 GO:0048027 mRNA 5'-UTR binding 4/1602 24/18639 0.166666666666667 1.93913857677903 0.14611394282336 0.428314401021417 GO:0004866 endopeptidase inhibitor activity 18/1602 161/18639 0.111801242236025 1.30078861051015 0.150567261331077 0.440289595481583 GO:0004707 MAP kinase activity 3/1602 16/18639 0.1875 2.1815308988764 0.153383667884713 0.443108373889171 GO:0004708 MAP kinase kinase activity 3/1602 16/18639 0.1875 2.1815308988764 0.153383667884713 0.443108373889171 GO:0005324 long-chain fatty acid transmembrane transporter activity 3/1602 16/18639 0.1875 2.1815308988764 0.153383667884713 0.443108373889171 GO:0015923 mannosidase activity 3/1602 16/18639 0.1875 2.1815308988764 0.153383667884713 0.443108373889171 GO:0022858 alanine transmembrane transporter activity 3/1602 16/18639 0.1875 2.1815308988764 0.153383667884713 0.443108373889171 GO:0008139 nuclear localization sequence binding 4/1602 25/18639 0.16 1.86157303370787 0.162846450294774 0.468183544597475 GO:0019211 phosphatase activator activity 4/1602 25/18639 0.16 1.86157303370787 0.162846450294774 0.468183544597475 GO:0008237 metallopeptidase activity 20/1602 184/18639 0.108695652173913 1.26465559355154 0.164124918648643 0.469601441875064 GO:0061135 endopeptidase regulator activity 20/1602 184/18639 0.108695652173913 1.26465559355154 0.164124918648643 0.469601441875064 GO:0005246 calcium channel regulator activity 7/1602 53/18639 0.132075471698113 1.53667585329659 0.167105132788249 0.475851759082728 GO:0008146 sulfotransferase activity 7/1602 53/18639 0.132075471698113 1.53667585329659 0.167105132788249 0.475851759082728 GO:0022824 transmitter-gated monoatomic ion channel activity 8/1602 63/18639 0.126984126984127 1.47743891564116 0.170964330716303 0.484533979944782 GO:0022835 transmitter-gated channel activity 8/1602 63/18639 0.126984126984127 1.47743891564116 0.170964330716303 0.484533979944782 GO:0043014 alpha-tubulin binding 6/1602 44/18639 0.136363636363636 1.58656792645557 0.173227975446024 0.486846984229126 GO:0001540 amyloid-beta binding 10/1602 83/18639 0.120481927710843 1.40178692297279 0.173832715807899 0.486846984229126 GO:0004029 aldehyde dehydrogenase (NAD+) activity 3/1602 17/18639 0.176470588235294 2.05320555188367 0.175036959212813 0.486846984229126 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 3/1602 17/18639 0.176470588235294 2.05320555188367 0.175036959212813 0.486846984229126 GO:0015278 intracellularly gated calcium channel activity 3/1602 17/18639 0.176470588235294 2.05320555188367 0.175036959212813 0.486846984229126 GO:0031489 myosin V binding 3/1602 17/18639 0.176470588235294 2.05320555188367 0.175036959212813 0.486846984229126 GO:0038191 neuropilin binding 3/1602 17/18639 0.176470588235294 2.05320555188367 0.175036959212813 0.486846984229126 GO:0045236 CXCR chemokine receptor binding 3/1602 17/18639 0.176470588235294 2.05320555188367 0.175036959212813 0.486846984229126 GO:0005154 epidermal growth factor receptor binding 5/1602 35/18639 0.142857142857143 1.66211878009631 0.178152319127731 0.493217994622144 GO:0010485 histone H4 acetyltransferase activity 5/1602 35/18639 0.142857142857143 1.66211878009631 0.178152319127731 0.493217994622144 GO:0050681 nuclear androgen receptor binding 4/1602 26/18639 0.153846153846154 1.78997407087295 0.180228305297215 0.496666021049467 GO:0070006 metalloaminopeptidase activity 4/1602 26/18639 0.153846153846154 1.78997407087295 0.180228305297215 0.496666021049467 GO:0008194 UDP-glycosyltransferase activity 16/1602 145/18639 0.110344827586207 1.28384347152267 0.180776370272942 0.497031123784916 GO:0031491 nucleosome binding 9/1602 74/18639 0.121621621621622 1.41504706954145 0.183010860797975 0.502020618152243 GO:0042605 peptide antigen binding 6/1602 45/18639 0.133333333333333 1.55131086142322 0.186387308136326 0.510112632794156 GO:0000993 RNA polymerase II complex binding 5/1602 36/18639 0.138888888888889 1.61594881398252 0.193301865876296 0.527821500057225 GO:0008094 ATP-dependent activity, acting on DNA 22/1602 210/18639 0.104761904761905 1.21888710540396 0.193740500439065 0.527821500057225 GO:0016247 channel regulator activity 18/1602 168/18639 0.107142857142857 1.24658908507223 0.195485703123642 0.52953883059531 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 3/1602 18/18639 0.166666666666667 1.93913857677903 0.197470165924338 0.52953883059531 GO:0004706 JUN kinase kinase kinase activity 3/1602 18/18639 0.166666666666667 1.93913857677903 0.197470165924338 0.52953883059531 GO:0008525 phosphatidylcholine transporter activity 3/1602 18/18639 0.166666666666667 1.93913857677903 0.197470165924338 0.52953883059531 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 3/1602 18/18639 0.166666666666667 1.93913857677903 0.197470165924338 0.52953883059531 GO:0034185 apolipoprotein binding 3/1602 18/18639 0.166666666666667 1.93913857677903 0.197470165924338 0.52953883059531 GO:1901611 phosphatidylglycerol binding 3/1602 18/18639 0.166666666666667 1.93913857677903 0.197470165924338 0.52953883059531 GO:0005044 scavenger receptor activity 4/1602 27/18639 0.148148148148148 1.72367873491469 0.198190409470618 0.530281274556732 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 6/1602 46/18639 0.130434782608696 1.51758671226185 0.199920847407246 0.5337172622747 GO:0030414 peptidase inhibitor activity 18/1602 169/18639 0.106508875739645 1.23921281829666 0.202387692789581 0.539099511305876 GO:0042578 phosphoric ester hydrolase activity 36/1602 363/18639 0.0991735537190083 1.15386758287678 0.20551268478213 0.539152153964545 GO:0023023 MHC protein complex binding 5/1602 37/18639 0.135135135135135 1.57227452171272 0.208882005692822 0.539152153964545 GO:0141108 transporter regulator activity 18/1602 170/18639 0.105882352941176 1.2319233311302 0.209403494579587 0.539152153964545 GO:0008190 eukaryotic initiation factor 4E binding 2/1602 10/18639 0.2 2.32696629213483 0.210070989755416 0.539152153964545 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 2/1602 10/18639 0.2 2.32696629213483 0.210070989755416 0.539152153964545 GO:0015203 polyamine transmembrane transporter activity 2/1602 10/18639 0.2 2.32696629213483 0.210070989755416 0.539152153964545 GO:0015924 mannosyl-oligosaccharide mannosidase activity 2/1602 10/18639 0.2 2.32696629213483 0.210070989755416 0.539152153964545 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 2/1602 10/18639 0.2 2.32696629213483 0.210070989755416 0.539152153964545 GO:0019911 structural constituent of myelin sheath 2/1602 10/18639 0.2 2.32696629213483 0.210070989755416 0.539152153964545 GO:0031434 mitogen-activated protein kinase kinase binding 2/1602 10/18639 0.2 2.32696629213483 0.210070989755416 0.539152153964545 GO:0032052 bile acid binding 2/1602 10/18639 0.2 2.32696629213483 0.210070989755416 0.539152153964545 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 2/1602 10/18639 0.2 2.32696629213483 0.210070989755416 0.539152153964545 GO:0042975 peroxisome proliferator activated receptor binding 2/1602 10/18639 0.2 2.32696629213483 0.210070989755416 0.539152153964545 GO:0043208 glycosphingolipid binding 2/1602 10/18639 0.2 2.32696629213483 0.210070989755416 0.539152153964545 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 2/1602 10/18639 0.2 2.32696629213483 0.210070989755416 0.539152153964545 GO:0050815 phosphoserine residue binding 2/1602 10/18639 0.2 2.32696629213483 0.210070989755416 0.539152153964545 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 2/1602 10/18639 0.2 2.32696629213483 0.210070989755416 0.539152153964545 GO:0003724 RNA helicase activity 9/1602 77/18639 0.116883116883117 1.35991536553334 0.214457584406675 0.54784082374314 GO:0016504 peptidase activator activity 7/1602 57/18639 0.12280701754386 1.42883895131086 0.215616958210718 0.54784082374314 GO:0004843 cysteine-type deubiquitinase activity 12/1602 108/18639 0.111111111111111 1.29275905118602 0.2165290268808 0.54784082374314 GO:0019789 SUMO transferase activity 4/1602 28/18639 0.142857142857143 1.66211878009631 0.216662800694402 0.54784082374314 GO:0036408 histone H3K14 acetyltransferase activity 4/1602 28/18639 0.142857142857143 1.66211878009631 0.216662800694402 0.54784082374314 GO:0046625 sphingolipid binding 4/1602 28/18639 0.142857142857143 1.66211878009631 0.216662800694402 0.54784082374314 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 4/1602 28/18639 0.142857142857143 1.66211878009631 0.216662800694402 0.54784082374314 GO:0042626 ATPase-coupled transmembrane transporter activity 11/1602 98/18639 0.112244897959184 1.30595047007567 0.219773026743786 0.550660301576781 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 3/1602 19/18639 0.157894736842105 1.83707865168539 0.220540371618126 0.550660301576781 GO:0005346 purine ribonucleotide transmembrane transporter activity 3/1602 19/18639 0.157894736842105 1.83707865168539 0.220540371618126 0.550660301576781 GO:0005520 insulin-like growth factor binding 3/1602 19/18639 0.157894736842105 1.83707865168539 0.220540371618126 0.550660301576781 GO:0015245 fatty acid transmembrane transporter activity 3/1602 19/18639 0.157894736842105 1.83707865168539 0.220540371618126 0.550660301576781 GO:0097001 ceramide binding 3/1602 19/18639 0.157894736842105 1.83707865168539 0.220540371618126 0.550660301576781 GO:0032266 phosphatidylinositol-3-phosphate binding 6/1602 48/18639 0.125 1.45435393258427 0.228001085536762 0.568102704795765 GO:0008083 growth factor activity 17/1602 162/18639 0.104938271604938 1.22093910389791 0.228501667986235 0.568166309587394 GO:0003785 actin monomer binding 4/1602 29/18639 0.137931034482759 1.60480433940333 0.235575448425157 0.582746769663223 GO:0010484 histone H3 acetyltransferase activity 4/1602 29/18639 0.137931034482759 1.60480433940333 0.235575448425157 0.582746769663223 GO:0008186 ATP-dependent activity, acting on RNA 9/1602 79/18639 0.113924050632911 1.32548712843123 0.236521528115098 0.582746769663223 GO:0000217 DNA secondary structure binding 5/1602 39/18639 0.128205128205128 1.49164505906079 0.241166267915049 0.582746769663223 GO:0015459 potassium channel regulator activity 7/1602 59/18639 0.11864406779661 1.38040373262236 0.24159081085151 0.582746769663223 GO:0031593 polyubiquitin modification-dependent protein binding 7/1602 59/18639 0.11864406779661 1.38040373262236 0.24159081085151 0.582746769663223 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 2/1602 11/18639 0.181818181818182 2.11542390194076 0.242979421212385 0.582746769663223 GO:0005536 D-glucose binding 2/1602 11/18639 0.181818181818182 2.11542390194076 0.242979421212385 0.582746769663223 GO:0008526 phosphatidylinositol transfer activity 2/1602 11/18639 0.181818181818182 2.11542390194076 0.242979421212385 0.582746769663223 GO:0016176 superoxide-generating NADPH oxidase activator activity 2/1602 11/18639 0.181818181818182 2.11542390194076 0.242979421212385 0.582746769663223 GO:0050786 RAGE receptor binding 2/1602 11/18639 0.181818181818182 2.11542390194076 0.242979421212385 0.582746769663223 GO:0050998 nitric-oxide synthase binding 2/1602 11/18639 0.181818181818182 2.11542390194076 0.242979421212385 0.582746769663223 GO:0140031 phosphorylation-dependent protein binding 2/1602 11/18639 0.181818181818182 2.11542390194076 0.242979421212385 0.582746769663223 GO:0140537 transcription regulator activator activity 2/1602 11/18639 0.181818181818182 2.11542390194076 0.242979421212385 0.582746769663223 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 2/1602 11/18639 0.181818181818182 2.11542390194076 0.242979421212385 0.582746769663223 GO:0180030 inositol phosphate kinase activity 2/1602 11/18639 0.181818181818182 2.11542390194076 0.242979421212385 0.582746769663223 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 3/1602 20/18639 0.15 1.74522471910112 0.244110477927487 0.582746769663223 GO:0010851 cyclase regulator activity 3/1602 20/18639 0.15 1.74522471910112 0.244110477927487 0.582746769663223 GO:0030742 GTP-dependent protein binding 3/1602 20/18639 0.15 1.74522471910112 0.244110477927487 0.582746769663223 GO:0061608 nuclear import signal receptor activity 3/1602 20/18639 0.15 1.74522471910112 0.244110477927487 0.582746769663223 GO:0000287 magnesium ion binding 23/1602 230/18639 0.1 1.16348314606742 0.25294793267804 0.60120573727649 GO:0001968 fibronectin binding 4/1602 30/18639 0.133333333333333 1.55131086142322 0.254858953845469 0.60120573727649 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 4/1602 30/18639 0.133333333333333 1.55131086142322 0.254858953845469 0.60120573727649 GO:0043995 histone H4K5 acetyltransferase activity 4/1602 30/18639 0.133333333333333 1.55131086142322 0.254858953845469 0.60120573727649 GO:0043996 histone H4K8 acetyltransferase activity 4/1602 30/18639 0.133333333333333 1.55131086142322 0.254858953845469 0.60120573727649 GO:0043997 histone H4K12 acetyltransferase activity 4/1602 30/18639 0.133333333333333 1.55131086142322 0.254858953845469 0.60120573727649 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 5/1602 40/18639 0.125 1.45435393258427 0.257785264077142 0.606911763457209 GO:0015171 amino acid transmembrane transporter activity 11/1602 102/18639 0.107843137254902 1.25473672615113 0.259716269816778 0.610256696858283 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 17/1602 167/18639 0.101796407185629 1.18438404090695 0.267779845827008 0.622979385861525 GO:0009931 calcium-dependent protein serine/threonine kinase activity 3/1602 21/18639 0.142857142857143 1.66211878009631 0.268050372621994 0.622979385861525 GO:0072542 protein phosphatase activator activity 3/1602 21/18639 0.142857142857143 1.66211878009631 0.268050372621994 0.622979385861525 GO:0019905 syntaxin binding 7/1602 61/18639 0.114754098360656 1.33514459384785 0.268489799048378 0.622979385861525 GO:0003743 translation initiation factor activity 6/1602 51/18639 0.117647058823529 1.36880370125578 0.272225350450823 0.622979385861525 GO:0001727 lipid kinase activity 5/1602 41/18639 0.121951219512195 1.41888188544807 0.274665273919243 0.622979385861525 GO:0140318 protein transporter activity 5/1602 41/18639 0.121951219512195 1.41888188544807 0.274665273919243 0.622979385861525 GO:0000340 RNA 7-methylguanosine cap binding 2/1602 12/18639 0.166666666666667 1.93913857677903 0.276069460289806 0.622979385861525 GO:0004032 aldose reductase (NADPH) activity 2/1602 12/18639 0.166666666666667 1.93913857677903 0.276069460289806 0.622979385861525 GO:0004859 phospholipase inhibitor activity 2/1602 12/18639 0.166666666666667 1.93913857677903 0.276069460289806 0.622979385861525 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 2/1602 12/18639 0.166666666666667 1.93913857677903 0.276069460289806 0.622979385861525 GO:0031543 peptidyl-proline dioxygenase activity 2/1602 12/18639 0.166666666666667 1.93913857677903 0.276069460289806 0.622979385861525 GO:0034452 dynactin binding 2/1602 12/18639 0.166666666666667 1.93913857677903 0.276069460289806 0.622979385861525 GO:0070679 inositol 1,4,5 trisphosphate binding 2/1602 12/18639 0.166666666666667 1.93913857677903 0.276069460289806 0.622979385861525 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 2/1602 12/18639 0.166666666666667 1.93913857677903 0.276069460289806 0.622979385861525 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 2/1602 12/18639 0.166666666666667 1.93913857677903 0.276069460289806 0.622979385861525 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 2/1602 12/18639 0.166666666666667 1.93913857677903 0.276069460289806 0.622979385861525 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 2/1602 12/18639 0.166666666666667 1.93913857677903 0.276069460289806 0.622979385861525 GO:0141221 histone deacetylase activity, hydrolytic mechanism 2/1602 12/18639 0.166666666666667 1.93913857677903 0.276069460289806 0.622979385861525 GO:1990247 N6-methyladenosine-containing RNA reader activity 2/1602 12/18639 0.166666666666667 1.93913857677903 0.276069460289806 0.622979385861525 GO:1990817 poly(A) RNA polymerase activity 2/1602 12/18639 0.166666666666667 1.93913857677903 0.276069460289806 0.622979385861525 GO:0005525 GTP binding 36/1602 378/18639 0.0952380952380952 1.10807918673087 0.28261006529965 0.63357436399561 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 9/1602 83/18639 0.108433734939759 1.26160823067551 0.282838314670153 0.63357436399561 GO:0008135 translation factor activity, RNA binding 9/1602 83/18639 0.108433734939759 1.26160823067551 0.282838314670153 0.63357436399561 GO:0140658 ATP-dependent chromatin remodeler activity 16/1602 158/18639 0.10126582278481 1.17821078082776 0.282883537101719 0.63357436399561 GO:0101005 deubiquitinase activity 12/1602 115/18639 0.104347826086957 1.21406936980948 0.283855830125798 0.63456368753356 GO:0042562 hormone binding 10/1602 94/18639 0.106382978723404 1.23774802773129 0.287531349815459 0.641581146230016 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 8/1602 73/18639 0.10958904109589 1.27505002308758 0.289451316865891 0.643386964354884 GO:0004402 histone acetyltransferase activity 5/1602 42/18639 0.119047619047619 1.38509898341359 0.291763972326726 0.643386964354884 GO:0019894 kinesin binding 5/1602 42/18639 0.119047619047619 1.38509898341359 0.291763972326726 0.643386964354884 GO:0043175 RNA polymerase core enzyme binding 5/1602 42/18639 0.119047619047619 1.38509898341359 0.291763972326726 0.643386964354884 GO:0048487 beta-tubulin binding 5/1602 42/18639 0.119047619047619 1.38509898341359 0.291763972326726 0.643386964354884 GO:0050321 tau-protein kinase activity 3/1602 22/18639 0.136363636363636 1.58656792645557 0.292237758976802 0.643386964354884 GO:0140517 protein-RNA adaptor activity 3/1602 22/18639 0.136363636363636 1.58656792645557 0.292237758976802 0.643386964354884 GO:0008378 galactosyltransferase activity 4/1602 32/18639 0.125 1.45435393258427 0.294267664486677 0.643386964354884 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 4/1602 32/18639 0.125 1.45435393258427 0.294267664486677 0.643386964354884 GO:0046982 protein heterodimerization activity 35/1602 369/18639 0.0948509485094851 1.10357479979294 0.294457984089498 0.643386964354884 GO:0004860 protein kinase inhibitor activity 9/1602 84/18639 0.107142857142857 1.24658908507223 0.294796033834846 0.643386964354884 GO:0180051 translation factor activity 9/1602 84/18639 0.107142857142857 1.24658908507223 0.294796033834846 0.643386964354884 GO:0019783 ubiquitin-like protein peptidase activity 13/1602 127/18639 0.102362204724409 1.19096699991153 0.296160453422229 0.645187435870649 GO:0000149 SNARE binding 11/1602 106/18639 0.10377358490566 1.20738817044732 0.301868463479173 0.65308142538038 GO:0003684 damaged DNA binding 8/1602 74/18639 0.108108108108108 1.25781961737018 0.302353190328669 0.65308142538038 GO:0017046 peptide hormone binding 6/1602 53/18639 0.113207547169811 1.31715073139707 0.302768821304245 0.65308142538038 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 6/1602 53/18639 0.113207547169811 1.31715073139707 0.302768821304245 0.65308142538038 GO:0008375 acetylglucosaminyltransferase activity 5/1602 43/18639 0.116279069767442 1.35288737914816 0.309039637421185 0.65308142538038 GO:0004993 G protein-coupled serotonin receptor activity 2/1602 13/18639 0.153846153846154 1.78997407087295 0.309066962178341 0.65308142538038 GO:0008035 high-density lipoprotein particle binding 2/1602 13/18639 0.153846153846154 1.78997407087295 0.309066962178341 0.65308142538038 GO:0017154 semaphorin receptor activity 2/1602 13/18639 0.153846153846154 1.78997407087295 0.309066962178341 0.65308142538038 GO:0031994 insulin-like growth factor I binding 2/1602 13/18639 0.153846153846154 1.78997407087295 0.309066962178341 0.65308142538038 GO:0039706 co-receptor binding 2/1602 13/18639 0.153846153846154 1.78997407087295 0.309066962178341 0.65308142538038 GO:0045159 myosin II binding 2/1602 13/18639 0.153846153846154 1.78997407087295 0.309066962178341 0.65308142538038 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 2/1602 13/18639 0.153846153846154 1.78997407087295 0.309066962178341 0.65308142538038 GO:0061459 L-arginine transmembrane transporter activity 2/1602 13/18639 0.153846153846154 1.78997407087295 0.309066962178341 0.65308142538038 GO:0071714 icosanoid transmembrane transporter activity 2/1602 13/18639 0.153846153846154 1.78997407087295 0.309066962178341 0.65308142538038 GO:0071837 HMG box domain binding 2/1602 13/18639 0.153846153846154 1.78997407087295 0.309066962178341 0.65308142538038 GO:0097157 pre-mRNA intronic binding 2/1602 13/18639 0.153846153846154 1.78997407087295 0.309066962178341 0.65308142538038 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 2/1602 13/18639 0.153846153846154 1.78997407087295 0.309066962178341 0.65308142538038 GO:0000295 adenine nucleotide transmembrane transporter activity 3/1602 23/18639 0.130434782608696 1.51758671226185 0.31655870408529 0.657298975843763 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 3/1602 23/18639 0.130434782608696 1.51758671226185 0.31655870408529 0.657298975843763 GO:0004022 alcohol dehydrogenase (NAD+) activity 3/1602 23/18639 0.130434782608696 1.51758671226185 0.31655870408529 0.657298975843763 GO:0005212 structural constituent of eye lens 3/1602 23/18639 0.130434782608696 1.51758671226185 0.31655870408529 0.657298975843763 GO:0005283 amino acid:sodium symporter activity 3/1602 23/18639 0.130434782608696 1.51758671226185 0.31655870408529 0.657298975843763 GO:0008171 O-methyltransferase activity 3/1602 23/18639 0.130434782608696 1.51758671226185 0.31655870408529 0.657298975843763 GO:0031681 G-protein beta-subunit binding 3/1602 23/18639 0.130434782608696 1.51758671226185 0.31655870408529 0.657298975843763 GO:0043274 phospholipase binding 3/1602 23/18639 0.130434782608696 1.51758671226185 0.31655870408529 0.657298975843763 GO:0140103 catalytic activity, acting on a glycoprotein 3/1602 23/18639 0.130434782608696 1.51758671226185 0.31655870408529 0.657298975843763 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 3/1602 23/18639 0.130434782608696 1.51758671226185 0.31655870408529 0.657298975843763 GO:0030594 neurotransmitter receptor activity 10/1602 97/18639 0.103092783505155 1.19946716089424 0.321709974105144 0.66683731200997 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 4/1602 34/18639 0.117647058823529 1.36880370125578 0.334367359339049 0.690679381294478 GO:0052866 phosphatidylinositol phosphate phosphatase activity 4/1602 34/18639 0.117647058823529 1.36880370125578 0.334367359339049 0.690679381294478 GO:0031072 heat shock protein binding 13/1602 131/18639 0.099236641221374 1.15460159533408 0.335764253079556 0.691182894196792 GO:0061775 cohesin loader activity 15/1602 153/18639 0.0980392156862745 1.14066975104649 0.335766941077204 0.691182894196792 GO:0004065 arylsulfatase activity 2/1602 14/18639 0.142857142857143 1.66211878009631 0.341743512309896 0.693930799189535 GO:0005347 ATP transmembrane transporter activity 2/1602 14/18639 0.142857142857143 1.66211878009631 0.341743512309896 0.693930799189535 GO:0008191 metalloendopeptidase inhibitor activity 2/1602 14/18639 0.142857142857143 1.66211878009631 0.341743512309896 0.693930799189535 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 2/1602 14/18639 0.142857142857143 1.66211878009631 0.341743512309896 0.693930799189535 GO:0030983 mismatched DNA binding 2/1602 14/18639 0.142857142857143 1.66211878009631 0.341743512309896 0.693930799189535 GO:0031404 chloride ion binding 2/1602 14/18639 0.142857142857143 1.66211878009631 0.341743512309896 0.693930799189535 GO:0046030 inositol trisphosphate phosphatase activity 2/1602 14/18639 0.142857142857143 1.66211878009631 0.341743512309896 0.693930799189535 GO:1901612 cardiolipin binding 2/1602 14/18639 0.142857142857143 1.66211878009631 0.341743512309896 0.693930799189535 GO:0004252 serine-type endopeptidase activity 17/1602 176/18639 0.0965909090909091 1.12381894790603 0.343711982638302 0.69674496819561 GO:0051082 unfolded protein binding 12/1602 121/18639 0.0991735537190083 1.15386758287678 0.345889506022005 0.699972672085141 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 6/1602 56/18639 0.107142857142857 1.24658908507223 0.34958999069446 0.705075259478202 GO:0170055 lipid transmembrane transporter activity 6/1602 56/18639 0.107142857142857 1.24658908507223 0.34958999069446 0.705075259478202 GO:0046943 carboxylic acid transmembrane transporter activity 18/1602 188/18639 0.0957446808510638 1.11397322495816 0.351342561013605 0.707417008370828 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 7/1602 67/18639 0.104477611940299 1.21557940633909 0.35299773067627 0.709357969742804 GO:0015399 primary active transmembrane transporter activity 16/1602 166/18639 0.0963855421686747 1.12142953837823 0.353492767530695 0.709357969742804 GO:0016229 steroid dehydrogenase activity 4/1602 35/18639 0.114285714285714 1.32969502407705 0.354524138721156 0.710235962999166 GO:0043130 ubiquitin binding 10/1602 100/18639 0.1 1.16348314606742 0.356678229916223 0.712320804208571 GO:0016757 glycosyltransferase activity 25/1602 267/18639 0.0936329588014981 1.08940369481968 0.356755988060982 0.712320804208571 GO:0005342 organic acid transmembrane transporter activity 18/1602 189/18639 0.0952380952380952 1.10807918673087 0.359855372499768 0.7171857599341 GO:0030276 clathrin binding 5/1602 46/18639 0.108695652173913 1.26465559355154 0.361525076089678 0.7171857599341 GO:0015271 outward rectifier potassium channel activity 3/1602 25/18639 0.12 1.3961797752809 0.365189070066778 0.7171857599341 GO:0015645 fatty acid ligase activity 3/1602 25/18639 0.12 1.3961797752809 0.365189070066778 0.7171857599341 GO:0015662 P-type ion transporter activity 3/1602 25/18639 0.12 1.3961797752809 0.365189070066778 0.7171857599341 GO:0017025 TBP-class protein binding 3/1602 25/18639 0.12 1.3961797752809 0.365189070066778 0.7171857599341 GO:0019706 protein-cysteine S-palmitoyltransferase activity 3/1602 25/18639 0.12 1.3961797752809 0.365189070066778 0.7171857599341 GO:0019707 protein-cysteine S-acyltransferase activity 3/1602 25/18639 0.12 1.3961797752809 0.365189070066778 0.7171857599341 GO:0120515 fatty acid-CoA ligase activity 3/1602 25/18639 0.12 1.3961797752809 0.365189070066778 0.7171857599341 GO:0140358 P-type transmembrane transporter activity 3/1602 25/18639 0.12 1.3961797752809 0.365189070066778 0.7171857599341 GO:0051087 protein-folding chaperone binding 13/1602 134/18639 0.0970149253731343 1.1287523058863 0.366158051567183 0.71781232055793 GO:0003777 microtubule motor activity 7/1602 68/18639 0.102941176470588 1.19770323859881 0.36740991561662 0.71781232055793 GO:0043022 ribosome binding 11/1602 112/18639 0.0982142857142857 1.14270666131621 0.367912627660958 0.71781232055793 GO:0033293 monocarboxylic acid binding 8/1602 79/18639 0.10126582278481 1.17821078082776 0.368387583380909 0.71781232055793 GO:0019210 kinase inhibitor activity 9/1602 90/18639 0.1 1.16348314606742 0.368661523661177 0.71781232055793 GO:0004089 carbonate dehydratase activity 2/1602 15/18639 0.133333333333333 1.55131086142322 0.373910598417718 0.71781232055793 GO:0005041 low-density lipoprotein particle receptor activity 2/1602 15/18639 0.133333333333333 1.55131086142322 0.373910598417718 0.71781232055793 GO:0008242 omega peptidase activity 2/1602 15/18639 0.133333333333333 1.55131086142322 0.373910598417718 0.71781232055793 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 2/1602 15/18639 0.133333333333333 1.55131086142322 0.373910598417718 0.71781232055793 GO:0017081 chloride channel regulator activity 2/1602 15/18639 0.133333333333333 1.55131086142322 0.373910598417718 0.71781232055793 GO:0031005 filamin binding 2/1602 15/18639 0.133333333333333 1.55131086142322 0.373910598417718 0.71781232055793 GO:0050780 dopamine receptor binding 2/1602 15/18639 0.133333333333333 1.55131086142322 0.373910598417718 0.71781232055793 GO:0141050 histone H3K deacetylase activity 2/1602 15/18639 0.133333333333333 1.55131086142322 0.373910598417718 0.71781232055793 GO:0141051 histone H4K deacetylase activity 2/1602 15/18639 0.133333333333333 1.55131086142322 0.373910598417718 0.71781232055793 GO:0004190 aspartic-type endopeptidase activity 4/1602 36/18639 0.111111111111111 1.29275905118602 0.374676922826763 0.718130768751296 GO:0061733 protein-lysine-acetyltransferase activity 5/1602 47/18639 0.106382978723404 1.23774802773129 0.379111222634119 0.724308342284995 GO:1990518 single-stranded 3'-5' DNA helicase activity 5/1602 47/18639 0.106382978723404 1.23774802773129 0.379111222634119 0.724308342284995 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 6/1602 58/18639 0.103448275862069 1.2036032545525 0.381144669486018 0.727031937328992 GO:0005112 Notch binding 3/1602 26/18639 0.115384615384615 1.34248055315471 0.389314387210635 0.736225765501068 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 3/1602 26/18639 0.115384615384615 1.34248055315471 0.389314387210635 0.736225765501068 GO:0008157 protein phosphatase 1 binding 3/1602 26/18639 0.115384615384615 1.34248055315471 0.389314387210635 0.736225765501068 GO:0015216 purine nucleotide transmembrane transporter activity 3/1602 26/18639 0.115384615384615 1.34248055315471 0.389314387210635 0.736225765501068 GO:0120014 phospholipid transfer activity 3/1602 26/18639 0.115384615384615 1.34248055315471 0.389314387210635 0.736225765501068 GO:0004722 protein serine/threonine phosphatase activity 10/1602 103/18639 0.0970873786407767 1.12959528744409 0.392125555405727 0.736225765501068 GO:0070001 aspartic-type peptidase activity 4/1602 37/18639 0.108108108108108 1.25781961737018 0.394773276418756 0.736225765501068 GO:0033192 calmodulin-dependent protein phosphatase activity 8/1602 81/18639 0.0987654320987654 1.14911915660979 0.395198111581677 0.736225765501068 GO:0140791 histone H2AXS140 phosphatase activity 8/1602 81/18639 0.0987654320987654 1.14911915660979 0.395198111581677 0.736225765501068 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 8/1602 81/18639 0.0987654320987654 1.14911915660979 0.395198111581677 0.736225765501068 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 8/1602 81/18639 0.0987654320987654 1.14911915660979 0.395198111581677 0.736225765501068 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 8/1602 81/18639 0.0987654320987654 1.14911915660979 0.395198111581677 0.736225765501068 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 8/1602 81/18639 0.0987654320987654 1.14911915660979 0.395198111581677 0.736225765501068 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 8/1602 81/18639 0.0987654320987654 1.14911915660979 0.395198111581677 0.736225765501068 GO:1990439 MAP kinase serine/threonine phosphatase activity 8/1602 81/18639 0.0987654320987654 1.14911915660979 0.395198111581677 0.736225765501068 GO:0016782 transferase activity, transferring sulphur-containing groups 7/1602 70/18639 0.1 1.16348314606742 0.396325395610787 0.736695456358144 GO:0043138 3'-5' DNA helicase activity 5/1602 48/18639 0.104166666666667 1.21196161048689 0.396682168808231 0.736695456358144 GO:0008236 serine-type peptidase activity 18/1602 194/18639 0.0927835051546392 1.07952044480482 0.402907025809992 0.741400117708739 GO:0003688 DNA replication origin binding 2/1602 16/18639 0.125 1.45435393258427 0.405414445636719 0.741400117708739 GO:0005159 insulin-like growth factor receptor binding 2/1602 16/18639 0.125 1.45435393258427 0.405414445636719 0.741400117708739 GO:0015378 sodium:chloride symporter activity 2/1602 16/18639 0.125 1.45435393258427 0.405414445636719 0.741400117708739 GO:0015562 efflux transmembrane transporter activity 2/1602 16/18639 0.125 1.45435393258427 0.405414445636719 0.741400117708739 GO:0031435 mitogen-activated protein kinase kinase kinase binding 2/1602 16/18639 0.125 1.45435393258427 0.405414445636719 0.741400117708739 GO:0043023 ribosomal large subunit binding 2/1602 16/18639 0.125 1.45435393258427 0.405414445636719 0.741400117708739 GO:0055102 lipase inhibitor activity 2/1602 16/18639 0.125 1.45435393258427 0.405414445636719 0.741400117708739 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 2/1602 16/18639 0.125 1.45435393258427 0.405414445636719 0.741400117708739 GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 2/1602 16/18639 0.125 1.45435393258427 0.405414445636719 0.741400117708739 GO:0051213 dioxygenase activity 9/1602 93/18639 0.0967741935483871 1.12595143167814 0.406337497144254 0.741953658907676 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 8/1602 82/18639 0.0975609756097561 1.13510550835845 0.408622941973624 0.743715007279913 GO:0033549 MAP kinase phosphatase activity 8/1602 82/18639 0.0975609756097561 1.13510550835845 0.408622941973624 0.743715007279913 GO:0019001 guanyl nucleotide binding 36/1602 400/18639 0.09 1.04713483146067 0.411049861610398 0.743715007279913 GO:0032561 guanyl ribonucleotide binding 36/1602 400/18639 0.09 1.04713483146067 0.411049861610398 0.743715007279913 GO:0004364 glutathione transferase activity 3/1602 27/18639 0.111111111111111 1.29275905118602 0.413204884428137 0.743715007279913 GO:0016405 CoA-ligase activity 3/1602 27/18639 0.111111111111111 1.29275905118602 0.413204884428137 0.743715007279913 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 3/1602 27/18639 0.111111111111111 1.29275905118602 0.413204884428137 0.743715007279913 GO:0035255 ionotropic glutamate receptor binding 3/1602 27/18639 0.111111111111111 1.29275905118602 0.413204884428137 0.743715007279913 GO:0016763 pentosyltransferase activity 5/1602 49/18639 0.102040816326531 1.18722770006879 0.414203882205203 0.743715007279913 GO:0000146 microfilament motor activity 4/1602 38/18639 0.105263157894737 1.2247191011236 0.414764138675336 0.743715007279913 GO:0042162 telomeric DNA binding 4/1602 38/18639 0.105263157894737 1.2247191011236 0.414764138675336 0.743715007279913 GO:0043531 ADP binding 4/1602 38/18639 0.105263157894737 1.2247191011236 0.414764138675336 0.743715007279913 GO:0140767 enzyme-substrate adaptor activity 13/1602 139/18639 0.0935251798561151 1.08814970495514 0.417541092716433 0.747573573186907 GO:0000510 H3-H4 histone complex chaperone activity 14/1602 151/18639 0.0927152317880795 1.07872609569164 0.424331709182001 0.755209410984633 GO:0140584 chromatin extrusion motor activity 14/1602 151/18639 0.0927152317880795 1.07872609569164 0.424331709182001 0.755209410984633 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 14/1602 151/18639 0.0927152317880795 1.07872609569164 0.424331709182001 0.755209410984633 GO:0140849 ATP-dependent H2AZ histone chaperone activity 14/1602 151/18639 0.0927152317880795 1.07872609569164 0.424331709182001 0.755209410984633 GO:0015026 coreceptor activity 6/1602 61/18639 0.0983606557377049 1.14440965186959 0.428456273598702 0.759262309776683 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 6/1602 61/18639 0.0983606557377049 1.14440965186959 0.428456273598702 0.759262309776683 GO:0016758 hexosyltransferase activity 18/1602 197/18639 0.0913705583756345 1.0630810471682 0.428972325540615 0.759262309776683 GO:0015616 DNA translocase activity 14/1602 152/18639 0.0921052631578947 1.07162921348315 0.43425545082158 0.759262309776683 GO:0140674 ATP-dependent histone chaperone activity 14/1602 152/18639 0.0921052631578947 1.07162921348315 0.43425545082158 0.759262309776683 GO:0017018 myosin phosphatase activity 8/1602 84/18639 0.0952380952380952 1.10807918673087 0.435434067312431 0.759262309776683 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 2/1602 17/18639 0.117647058823529 1.36880370125578 0.436131443826573 0.759262309776683 GO:0004659 prenyltransferase activity 2/1602 17/18639 0.117647058823529 1.36880370125578 0.436131443826573 0.759262309776683 GO:0005092 GDP-dissociation inhibitor activity 2/1602 17/18639 0.117647058823529 1.36880370125578 0.436131443826573 0.759262309776683 GO:0008429 phosphatidylethanolamine binding 2/1602 17/18639 0.117647058823529 1.36880370125578 0.436131443826573 0.759262309776683 GO:0008569 minus-end-directed microtubule motor activity 2/1602 17/18639 0.117647058823529 1.36880370125578 0.436131443826573 0.759262309776683 GO:0030548 acetylcholine receptor regulator activity 2/1602 17/18639 0.117647058823529 1.36880370125578 0.436131443826573 0.759262309776683 GO:0036041 long-chain fatty acid binding 2/1602 17/18639 0.117647058823529 1.36880370125578 0.436131443826573 0.759262309776683 GO:0045125 bioactive lipid receptor activity 2/1602 17/18639 0.117647058823529 1.36880370125578 0.436131443826573 0.759262309776683 GO:0070403 NAD+ binding 2/1602 17/18639 0.117647058823529 1.36880370125578 0.436131443826573 0.759262309776683 GO:0017171 serine hydrolase activity 18/1602 198/18639 0.0909090909090909 1.05771195097038 0.437674094816042 0.760840432267421 GO:0004857 enzyme inhibitor activity 37/1602 416/18639 0.0889423076923077 1.03482875972342 0.438507575408731 0.761182961086854 GO:0003678 DNA helicase activity 7/1602 74/18639 0.0945945945945946 1.10059216519891 0.453973172509209 0.780522504009755 GO:0004177 aminopeptidase activity 4/1602 40/18639 0.1 1.16348314606742 0.454250409917712 0.780522504009755 GO:0071949 FAD binding 4/1602 40/18639 0.1 1.16348314606742 0.454250409917712 0.780522504009755 GO:0008514 organic anion transmembrane transporter activity 24/1602 269/18639 0.0892193308550186 1.03805187753227 0.455237139818832 0.780522504009755 GO:0032182 ubiquitin-like protein binding 11/1602 120/18639 0.0916666666666667 1.06652621722846 0.457973422731593 0.780522504009755 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 3/1602 29/18639 0.103448275862069 1.2036032545525 0.460006990558995 0.780522504009755 GO:0005416 amino acid:monoatomic cation symporter activity 3/1602 29/18639 0.103448275862069 1.2036032545525 0.460006990558995 0.780522504009755 GO:0016417 S-acyltransferase activity 3/1602 29/18639 0.103448275862069 1.2036032545525 0.460006990558995 0.780522504009755 GO:0035250 UDP-galactosyltransferase activity 3/1602 29/18639 0.103448275862069 1.2036032545525 0.460006990558995 0.780522504009755 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 3/1602 29/18639 0.103448275862069 1.2036032545525 0.460006990558995 0.780522504009755 GO:0097472 cyclin-dependent protein kinase activity 3/1602 29/18639 0.103448275862069 1.2036032545525 0.460006990558995 0.780522504009755 GO:0033218 amide binding 22/1602 247/18639 0.0890688259109312 1.03630077787381 0.463134772474622 0.780522504009755 GO:0000400 four-way junction DNA binding 2/1602 18/18639 0.111111111111111 1.29275905118602 0.465964103564352 0.780522504009755 GO:0000900 mRNA regulatory element binding translation repressor activity 2/1602 18/18639 0.111111111111111 1.29275905118602 0.465964103564352 0.780522504009755 GO:0008409 5'-3' exonuclease activity 2/1602 18/18639 0.111111111111111 1.29275905118602 0.465964103564352 0.780522504009755 GO:0015172 acidic amino acid transmembrane transporter activity 2/1602 18/18639 0.111111111111111 1.29275905118602 0.465964103564352 0.780522504009755 GO:0015373 monoatomic anion:sodium symporter activity 2/1602 18/18639 0.111111111111111 1.29275905118602 0.465964103564352 0.780522504009755 GO:0017075 syntaxin-1 binding 2/1602 18/18639 0.111111111111111 1.29275905118602 0.465964103564352 0.780522504009755 GO:0017128 phospholipid scramblase activity 2/1602 18/18639 0.111111111111111 1.29275905118602 0.465964103564352 0.780522504009755 GO:0022851 GABA-gated chloride ion channel activity 2/1602 18/18639 0.111111111111111 1.29275905118602 0.465964103564352 0.780522504009755 GO:0030228 lipoprotein particle receptor activity 2/1602 18/18639 0.111111111111111 1.29275905118602 0.465964103564352 0.780522504009755 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 2/1602 18/18639 0.111111111111111 1.29275905118602 0.465964103564352 0.780522504009755 GO:0070628 proteasome binding 2/1602 18/18639 0.111111111111111 1.29275905118602 0.465964103564352 0.780522504009755 GO:0099602 neurotransmitter receptor regulator activity 2/1602 18/18639 0.111111111111111 1.29275905118602 0.465964103564352 0.780522504009755 GO:1990381 ubiquitin-specific protease binding 2/1602 18/18639 0.111111111111111 1.29275905118602 0.465964103564352 0.780522504009755 GO:0008137 NADH dehydrogenase (ubiquinone) activity 4/1602 41/18639 0.0975609756097561 1.13510550835845 0.473665019214843 0.789001898302162 GO:0008227 G protein-coupled amine receptor activity 4/1602 41/18639 0.0975609756097561 1.13510550835845 0.473665019214843 0.789001898302162 GO:0015175 neutral L-amino acid transmembrane transporter activity 4/1602 41/18639 0.0975609756097561 1.13510550835845 0.473665019214843 0.789001898302162 GO:0016877 ligase activity, forming carbon-sulfur bonds 4/1602 41/18639 0.0975609756097561 1.13510550835845 0.473665019214843 0.789001898302162 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 11/1602 122/18639 0.0901639344262295 1.04904218088046 0.480350230982638 0.793794794726751 GO:0001965 G-protein alpha-subunit binding 3/1602 30/18639 0.1 1.16348314606742 0.482801216860498 0.793794794726751 GO:0008106 alcohol dehydrogenase (NADP+) activity 3/1602 30/18639 0.1 1.16348314606742 0.482801216860498 0.793794794726751 GO:0015215 nucleotide transmembrane transporter activity 3/1602 30/18639 0.1 1.16348314606742 0.482801216860498 0.793794794726751 GO:0031210 phosphatidylcholine binding 3/1602 30/18639 0.1 1.16348314606742 0.482801216860498 0.793794794726751 GO:0031624 ubiquitin conjugating enzyme binding 3/1602 30/18639 0.1 1.16348314606742 0.482801216860498 0.793794794726751 GO:0070566 adenylyltransferase activity 3/1602 30/18639 0.1 1.16348314606742 0.482801216860498 0.793794794726751 GO:0098918 structural constituent of synapse 3/1602 30/18639 0.1 1.16348314606742 0.482801216860498 0.793794794726751 GO:0005544 calcium-dependent phospholipid binding 5/1602 53/18639 0.0943396226415094 1.09762560949756 0.483179440268457 0.793794794726751 GO:0034212 protein N-acetyltransferase activity 5/1602 53/18639 0.0943396226415094 1.09762560949756 0.483179440268457 0.793794794726751 GO:0008168 methyltransferase activity 18/1602 204/18639 0.0882352941176471 1.02660277594184 0.489733933504729 0.799764365698392 GO:0120013 lipid transfer activity 6/1602 65/18639 0.0923076923076923 1.07398444252377 0.490501900024882 0.799764365698392 GO:0051879 Hsp90 protein binding 4/1602 42/18639 0.0952380952380952 1.10807918673087 0.492812497834646 0.799764365698392 GO:0004890 GABA-A receptor activity 2/1602 19/18639 0.105263157894737 1.2247191011236 0.49483748379332 0.799764365698392 GO:0005229 intracellularly calcium-gated chloride channel activity 2/1602 19/18639 0.105263157894737 1.2247191011236 0.49483748379332 0.799764365698392 GO:0008574 plus-end-directed microtubule motor activity 2/1602 19/18639 0.105263157894737 1.2247191011236 0.49483748379332 0.799764365698392 GO:0030506 ankyrin binding 2/1602 19/18639 0.105263157894737 1.2247191011236 0.49483748379332 0.799764365698392 GO:0070003 threonine-type peptidase activity 2/1602 19/18639 0.105263157894737 1.2247191011236 0.49483748379332 0.799764365698392 GO:0099589 serotonin receptor activity 2/1602 19/18639 0.105263157894737 1.2247191011236 0.49483748379332 0.799764365698392 GO:0120227 acyl-CoA binding 2/1602 19/18639 0.105263157894737 1.2247191011236 0.49483748379332 0.799764365698392 GO:0140036 ubiquitin-modified protein reader activity 2/1602 19/18639 0.105263157894737 1.2247191011236 0.49483748379332 0.799764365698392 GO:0141147 intracellularly calcium-gated channel activity 2/1602 19/18639 0.105263157894737 1.2247191011236 0.49483748379332 0.799764365698392 GO:0015085 calcium ion transmembrane transporter activity 13/1602 147/18639 0.0884353741496599 1.02893067339295 0.499666812955449 0.805941000025744 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 5/1602 54/18639 0.0925925925925926 1.07729920932168 0.500006874597912 0.805941000025744 GO:0008327 methyl-CpG binding 3/1602 31/18639 0.0967741935483871 1.12595143167814 0.505125080278462 0.81072727560756 GO:0016878 acid-thiol ligase activity 3/1602 31/18639 0.0967741935483871 1.12595143167814 0.505125080278462 0.81072727560756 GO:0047499 calcium-independent phospholipase A2 activity 3/1602 31/18639 0.0967741935483871 1.12595143167814 0.505125080278462 0.81072727560756 GO:0008235 metalloexopeptidase activity 6/1602 66/18639 0.0909090909090909 1.05771195097038 0.50568774883214 0.81072727560756 GO:0003689 DNA clamp loader activity 14/1602 160/18639 0.0875 1.01804775280899 0.513000954086429 0.821350925150427 GO:0008238 exopeptidase activity 9/1602 102/18639 0.0882352941176471 1.02660277594184 0.518168887021739 0.828005912371866 GO:0000339 RNA cap binding 2/1602 20/18639 0.1 1.16348314606742 0.522696040000634 0.828005912371866 GO:0001972 retinoic acid binding 2/1602 20/18639 0.1 1.16348314606742 0.522696040000634 0.828005912371866 GO:0015095 magnesium ion transmembrane transporter activity 2/1602 20/18639 0.1 1.16348314606742 0.522696040000634 0.828005912371866 GO:0016004 phospholipase activator activity 2/1602 20/18639 0.1 1.16348314606742 0.522696040000634 0.828005912371866 GO:0031418 L-ascorbic acid binding 2/1602 20/18639 0.1 1.16348314606742 0.522696040000634 0.828005912371866 GO:0042288 MHC class I protein binding 2/1602 20/18639 0.1 1.16348314606742 0.522696040000634 0.828005912371866 GO:0052745 inositol phosphate phosphatase activity 2/1602 20/18639 0.1 1.16348314606742 0.522696040000634 0.828005912371866 GO:0031369 translation initiation factor binding 3/1602 32/18639 0.09375 1.0907654494382 0.526937916394854 0.829233878958217 GO:0047498 calcium-dependent phospholipase A2 activity 3/1602 32/18639 0.09375 1.0907654494382 0.526937916394854 0.829233878958217 GO:0071813 lipoprotein particle binding 3/1602 32/18639 0.09375 1.0907654494382 0.526937916394854 0.829233878958217 GO:0071814 protein-lipid complex binding 3/1602 32/18639 0.09375 1.0907654494382 0.526937916394854 0.829233878958217 GO:0140142 nucleocytoplasmic carrier activity 3/1602 32/18639 0.09375 1.0907654494382 0.526937916394854 0.829233878958217 GO:0003954 NADH dehydrogenase activity 4/1602 44/18639 0.0909090909090909 1.05771195097038 0.530181957076802 0.833242602712031 GO:0008234 cysteine-type peptidase activity 16/1602 187/18639 0.0855614973262032 0.995493600913297 0.545733860243534 0.841070017373722 GO:0031406 carboxylic acid binding 16/1602 187/18639 0.0855614973262032 0.995493600913297 0.545733860243534 0.841070017373722 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 11/1602 128/18639 0.0859375 0.999868328651685 0.54608393088459 0.841070017373722 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 3/1602 33/18639 0.0909090909090909 1.05771195097038 0.548205480453833 0.841070017373722 GO:0019956 chemokine binding 3/1602 33/18639 0.0909090909090909 1.05771195097038 0.548205480453833 0.841070017373722 GO:0046915 transition metal ion transmembrane transporter activity 4/1602 45/18639 0.0888888888888889 1.03420724094881 0.548350011517566 0.841070017373722 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 2/1602 21/18639 0.0952380952380952 1.10807918673087 0.549500847093123 0.841070017373722 GO:0005123 death receptor binding 2/1602 21/18639 0.0952380952380952 1.10807918673087 0.549500847093123 0.841070017373722 GO:0005248 voltage-gated sodium channel activity 2/1602 21/18639 0.0952380952380952 1.10807918673087 0.549500847093123 0.841070017373722 GO:0008373 sialyltransferase activity 2/1602 21/18639 0.0952380952380952 1.10807918673087 0.549500847093123 0.841070017373722 GO:0015174 basic amino acid transmembrane transporter activity 2/1602 21/18639 0.0952380952380952 1.10807918673087 0.549500847093123 0.841070017373722 GO:0051428 peptide hormone receptor binding 2/1602 21/18639 0.0952380952380952 1.10807918673087 0.549500847093123 0.841070017373722 GO:0070182 DNA polymerase binding 2/1602 21/18639 0.0952380952380952 1.10807918673087 0.549500847093123 0.841070017373722 GO:0098960 postsynaptic neurotransmitter receptor activity 6/1602 69/18639 0.0869565217391304 1.01172447484123 0.55017800185481 0.841070017373722 GO:0140713 histone chaperone activity 14/1602 164/18639 0.0853658536585366 0.993217319813648 0.551361765237561 0.841070017373722 GO:0140597 protein carrier chaperone 16/1602 188/18639 0.0851063829787234 0.990198422185035 0.55459837932787 0.841070017373722 GO:0043177 organic acid binding 16/1602 189/18639 0.0846560846560847 0.984959277094109 0.563403460462679 0.841070017373722 GO:0017116 single-stranded DNA helicase activity 5/1602 58/18639 0.0862068965517241 1.00300271212708 0.564959859331682 0.841070017373722 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 11/1602 130/18639 0.0846153846153846 0.984485738980121 0.56733727197666 0.841070017373722 GO:0030332 cyclin binding 3/1602 34/18639 0.0882352941176471 1.02660277594184 0.568899492174618 0.841070017373722 GO:0051427 hormone receptor binding 3/1602 34/18639 0.0882352941176471 1.02660277594184 0.568899492174618 0.841070017373722 GO:0090482 vitamin transmembrane transporter activity 3/1602 34/18639 0.0882352941176471 1.02660277594184 0.568899492174618 0.841070017373722 GO:0004407 histone deacetylase activity 2/1602 22/18639 0.0909090909090909 1.05771195097038 0.575227155904755 0.841070017373722 GO:0008970 phospholipase A1 activity 2/1602 22/18639 0.0909090909090909 1.05771195097038 0.575227155904755 0.841070017373722 GO:0015377 chloride:monoatomic cation symporter activity 2/1602 22/18639 0.0909090909090909 1.05771195097038 0.575227155904755 0.841070017373722 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 2/1602 22/18639 0.0909090909090909 1.05771195097038 0.575227155904755 0.841070017373722 GO:0033558 protein lysine deacetylase activity 2/1602 22/18639 0.0909090909090909 1.05771195097038 0.575227155904755 0.841070017373722 GO:0061133 endopeptidase activator activity 2/1602 22/18639 0.0909090909090909 1.05771195097038 0.575227155904755 0.841070017373722 GO:0070034 telomerase RNA binding 2/1602 22/18639 0.0909090909090909 1.05771195097038 0.575227155904755 0.841070017373722 GO:0140035 ubiquitin-like protein reader activity 2/1602 22/18639 0.0909090909090909 1.05771195097038 0.575227155904755 0.841070017373722 GO:0036002 pre-mRNA binding 5/1602 59/18639 0.0847457627118644 0.986002666158827 0.580516955610531 0.841070017373722 GO:0016741 transferase activity, transferring one-carbon groups 18/1602 215/18639 0.0837209302325581 0.974078912986674 0.582354474784123 0.841070017373722 GO:0005504 fatty acid binding 4/1602 47/18639 0.0851063829787234 0.990198422185035 0.58354115459224 0.841070017373722 GO:0061749 forked DNA-dependent helicase activity 4/1602 47/18639 0.0851063829787234 0.990198422185035 0.58354115459224 0.841070017373722 GO:0099095 ligand-gated monoatomic anion channel activity 4/1602 47/18639 0.0851063829787234 0.990198422185035 0.58354115459224 0.841070017373722 GO:0004623 phospholipase A2 activity 3/1602 35/18639 0.0857142857142857 0.997271268057785 0.588997181560881 0.841070017373722 GO:0005343 organic acid:sodium symporter activity 3/1602 35/18639 0.0857142857142857 0.997271268057785 0.588997181560881 0.841070017373722 GO:0043015 gamma-tubulin binding 3/1602 35/18639 0.0857142857142857 0.997271268057785 0.588997181560881 0.841070017373722 GO:0061631 ubiquitin conjugating enzyme activity 3/1602 35/18639 0.0857142857142857 0.997271268057785 0.588997181560881 0.841070017373722 GO:0004896 cytokine receptor activity 8/1602 96/18639 0.0833333333333333 0.969569288389513 0.589560773214815 0.841070017373722 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 1/1602 10/18639 0.1 1.16348314606742 0.592988647226919 0.841070017373722 GO:0004445 inositol-polyphosphate 5-phosphatase activity 1/1602 10/18639 0.1 1.16348314606742 0.592988647226919 0.841070017373722 GO:0005131 growth hormone receptor binding 1/1602 10/18639 0.1 1.16348314606742 0.592988647226919 0.841070017373722 GO:0005381 iron ion transmembrane transporter activity 1/1602 10/18639 0.1 1.16348314606742 0.592988647226919 0.841070017373722 GO:0008140 cAMP response element binding protein binding 1/1602 10/18639 0.1 1.16348314606742 0.592988647226919 0.841070017373722 GO:0008519 ammonium channel activity 1/1602 10/18639 0.1 1.16348314606742 0.592988647226919 0.841070017373722 GO:0008641 ubiquitin-like modifier activating enzyme activity 1/1602 10/18639 0.1 1.16348314606742 0.592988647226919 0.841070017373722 GO:0015279 store-operated calcium channel activity 1/1602 10/18639 0.1 1.16348314606742 0.592988647226919 0.841070017373722 GO:0015658 branched-chain amino acid transmembrane transporter activity 1/1602 10/18639 0.1 1.16348314606742 0.592988647226919 0.841070017373722 GO:0016427 tRNA (cytidine) methyltransferase activity 1/1602 10/18639 0.1 1.16348314606742 0.592988647226919 0.841070017373722 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 1/1602 10/18639 0.1 1.16348314606742 0.592988647226919 0.841070017373722 GO:0016868 intramolecular phosphotransferase activity 1/1602 10/18639 0.1 1.16348314606742 0.592988647226919 0.841070017373722 GO:0030957 Tat protein binding 1/1602 10/18639 0.1 1.16348314606742 0.592988647226919 0.841070017373722 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 1/1602 10/18639 0.1 1.16348314606742 0.592988647226919 0.841070017373722 GO:0031956 medium-chain fatty acid-CoA ligase activity 1/1602 10/18639 0.1 1.16348314606742 0.592988647226919 0.841070017373722 GO:0031957 very long-chain fatty acid-CoA ligase activity 1/1602 10/18639 0.1 1.16348314606742 0.592988647226919 0.841070017373722 GO:0032356 oxidized DNA binding 1/1602 10/18639 0.1 1.16348314606742 0.592988647226919 0.841070017373722 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 1/1602 10/18639 0.1 1.16348314606742 0.592988647226919 0.841070017373722 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 1/1602 10/18639 0.1 1.16348314606742 0.592988647226919 0.841070017373722 GO:0043295 glutathione binding 1/1602 10/18639 0.1 1.16348314606742 0.592988647226919 0.841070017373722 GO:0045322 unmethylated CpG binding 1/1602 10/18639 0.1 1.16348314606742 0.592988647226919 0.841070017373722 GO:0047429 nucleoside triphosphate diphosphatase activity 1/1602 10/18639 0.1 1.16348314606742 0.592988647226919 0.841070017373722 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 1/1602 10/18639 0.1 1.16348314606742 0.592988647226919 0.841070017373722 GO:0051378 serotonin binding 1/1602 10/18639 0.1 1.16348314606742 0.592988647226919 0.841070017373722 GO:0051864 histone H3K36 demethylase activity 1/1602 10/18639 0.1 1.16348314606742 0.592988647226919 0.841070017373722 GO:0051880 G-quadruplex DNA binding 1/1602 10/18639 0.1 1.16348314606742 0.592988647226919 0.841070017373722 GO:0070513 death domain binding 1/1602 10/18639 0.1 1.16348314606742 0.592988647226919 0.841070017373722 GO:0099122 RNA polymerase II C-terminal domain binding 1/1602 10/18639 0.1 1.16348314606742 0.592988647226919 0.841070017373722 GO:0140135 mechanosensitive monoatomic cation channel activity 1/1602 10/18639 0.1 1.16348314606742 0.592988647226919 0.841070017373722 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 1/1602 10/18639 0.1 1.16348314606742 0.592988647226919 0.841070017373722 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 1/1602 10/18639 0.1 1.16348314606742 0.592988647226919 0.841070017373722 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 1/1602 10/18639 0.1 1.16348314606742 0.592988647226919 0.841070017373722 GO:1990763 arrestin family protein binding 1/1602 10/18639 0.1 1.16348314606742 0.592988647226919 0.841070017373722 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 15/1602 181/18639 0.0828729281767956 0.964212551989571 0.59779523444134 0.841070017373722 GO:0003887 DNA-directed DNA polymerase activity 2/1602 23/18639 0.0869565217391304 1.01172447484123 0.599862246554228 0.841070017373722 GO:0004602 glutathione peroxidase activity 2/1602 23/18639 0.0869565217391304 1.01172447484123 0.599862246554228 0.841070017373722 GO:0016917 GABA receptor activity 2/1602 23/18639 0.0869565217391304 1.01172447484123 0.599862246554228 0.841070017373722 GO:0042171 lysophosphatidic acid acyltransferase activity 2/1602 23/18639 0.0869565217391304 1.01172447484123 0.599862246554228 0.841070017373722 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 2/1602 23/18639 0.0869565217391304 1.01172447484123 0.599862246554228 0.841070017373722 GO:0071617 lysophospholipid acyltransferase activity 2/1602 23/18639 0.0869565217391304 1.01172447484123 0.599862246554228 0.841070017373722 GO:0099186 structural constituent of postsynapse 2/1602 23/18639 0.0869565217391304 1.01172447484123 0.599862246554228 0.841070017373722 GO:0009378 four-way junction helicase activity 4/1602 48/18639 0.0833333333333333 0.969569288389513 0.600528335118059 0.841070017373722 GO:0036121 double-stranded DNA helicase activity 4/1602 48/18639 0.0833333333333333 0.969569288389513 0.600528335118059 0.841070017373722 GO:0004033 aldo-keto reductase (NADPH) activity 3/1602 36/18639 0.0833333333333333 0.969569288389513 0.6084808414458 0.841070017373722 GO:0005484 SNAP receptor activity 3/1602 36/18639 0.0833333333333333 0.969569288389513 0.6084808414458 0.841070017373722 GO:0016409 palmitoyltransferase activity 3/1602 36/18639 0.0833333333333333 0.969569288389513 0.6084808414458 0.841070017373722 GO:0044390 ubiquitin-like protein conjugating enzyme binding 3/1602 36/18639 0.0833333333333333 0.969569288389513 0.6084808414458 0.841070017373722 GO:0050660 flavin adenine dinucleotide binding 7/1602 86/18639 0.0813953488372093 0.947021165403711 0.616093617902026 0.841070017373722 GO:0048029 monosaccharide binding 6/1602 74/18639 0.0810810810810811 0.943364713027634 0.619929770651866 0.841070017373722 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 2/1602 24/18639 0.0833333333333333 0.969569288389513 0.623403545723328 0.841070017373722 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 2/1602 24/18639 0.0833333333333333 0.969569288389513 0.623403545723328 0.841070017373722 GO:0004622 lysophospholipase activity 2/1602 24/18639 0.0833333333333333 0.969569288389513 0.623403545723328 0.841070017373722 GO:0005315 phosphate transmembrane transporter activity 2/1602 24/18639 0.0833333333333333 0.969569288389513 0.623403545723328 0.841070017373722 GO:0015149 hexose transmembrane transporter activity 2/1602 24/18639 0.0833333333333333 0.969569288389513 0.623403545723328 0.841070017373722 GO:0030552 cAMP binding 2/1602 24/18639 0.0833333333333333 0.969569288389513 0.623403545723328 0.841070017373722 GO:0042625 ATPase-coupled ion transmembrane transporter activity 2/1602 24/18639 0.0833333333333333 0.969569288389513 0.623403545723328 0.841070017373722 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 2/1602 24/18639 0.0833333333333333 0.969569288389513 0.623403545723328 0.841070017373722 GO:0046961 proton-transporting ATPase activity, rotational mechanism 2/1602 24/18639 0.0833333333333333 0.969569288389513 0.623403545723328 0.841070017373722 GO:0055056 D-glucose transmembrane transporter activity 2/1602 24/18639 0.0833333333333333 0.969569288389513 0.623403545723328 0.841070017373722 GO:0060229 lipase activator activity 2/1602 24/18639 0.0833333333333333 0.969569288389513 0.623403545723328 0.841070017373722 GO:0140612 DNA damage sensor activity 2/1602 24/18639 0.0833333333333333 0.969569288389513 0.623403545723328 0.841070017373722 GO:0015179 L-amino acid transmembrane transporter activity 5/1602 62/18639 0.0806451612903226 0.938292859731787 0.625322746020185 0.841070017373722 GO:0000099 sulfur amino acid transmembrane transporter activity 1/1602 11/18639 0.0909090909090909 1.05771195097038 0.627989569828373 0.841070017373722 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 1/1602 11/18639 0.0909090909090909 1.05771195097038 0.627989569828373 0.841070017373722 GO:0003953 NAD+ nucleosidase activity 1/1602 11/18639 0.0909090909090909 1.05771195097038 0.627989569828373 0.841070017373722 GO:0005221 intracellularly cyclic nucleotide-activated monoatomic cation channel activity 1/1602 11/18639 0.0909090909090909 1.05771195097038 0.627989569828373 0.841070017373722 GO:0005225 volume-sensitive anion channel activity 1/1602 11/18639 0.0909090909090909 1.05771195097038 0.627989569828373 0.841070017373722 GO:0008172 S-methyltransferase activity 1/1602 11/18639 0.0909090909090909 1.05771195097038 0.627989569828373 0.841070017373722 GO:0008199 ferric iron binding 1/1602 11/18639 0.0909090909090909 1.05771195097038 0.627989569828373 0.841070017373722 GO:0008503 benzodiazepine receptor activity 1/1602 11/18639 0.0909090909090909 1.05771195097038 0.627989569828373 0.841070017373722 GO:0015173 aromatic amino acid transmembrane transporter activity 1/1602 11/18639 0.0909090909090909 1.05771195097038 0.627989569828373 0.841070017373722 GO:0015217 ADP transmembrane transporter activity 1/1602 11/18639 0.0909090909090909 1.05771195097038 0.627989569828373 0.841070017373722 GO:0016594 glycine binding 1/1602 11/18639 0.0909090909090909 1.05771195097038 0.627989569828373 0.841070017373722 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 1/1602 11/18639 0.0909090909090909 1.05771195097038 0.627989569828373 0.841070017373722 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 1/1602 11/18639 0.0909090909090909 1.05771195097038 0.627989569828373 0.841070017373722 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 1/1602 11/18639 0.0909090909090909 1.05771195097038 0.627989569828373 0.841070017373722 GO:0019107 myristoyltransferase activity 1/1602 11/18639 0.0909090909090909 1.05771195097038 0.627989569828373 0.841070017373722 GO:0019206 nucleoside kinase activity 1/1602 11/18639 0.0909090909090909 1.05771195097038 0.627989569828373 0.841070017373722 GO:0032050 clathrin heavy chain binding 1/1602 11/18639 0.0909090909090909 1.05771195097038 0.627989569828373 0.841070017373722 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 1/1602 11/18639 0.0909090909090909 1.05771195097038 0.627989569828373 0.841070017373722 GO:0032404 mismatch repair complex binding 1/1602 11/18639 0.0909090909090909 1.05771195097038 0.627989569828373 0.841070017373722 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 1/1602 11/18639 0.0909090909090909 1.05771195097038 0.627989569828373 0.841070017373722 GO:0035252 UDP-xylosyltransferase activity 1/1602 11/18639 0.0909090909090909 1.05771195097038 0.627989569828373 0.841070017373722 GO:0042285 xylosyltransferase activity 1/1602 11/18639 0.0909090909090909 1.05771195097038 0.627989569828373 0.841070017373722 GO:0042608 T cell receptor binding 1/1602 11/18639 0.0909090909090909 1.05771195097038 0.627989569828373 0.841070017373722 GO:0043522 leucine zipper domain binding 1/1602 11/18639 0.0909090909090909 1.05771195097038 0.627989569828373 0.841070017373722 GO:0043855 cyclic nucleotide-activated monoatomic ion channel activity 1/1602 11/18639 0.0909090909090909 1.05771195097038 0.627989569828373 0.841070017373722 GO:0070697 activin receptor binding 1/1602 11/18639 0.0909090909090909 1.05771195097038 0.627989569828373 0.841070017373722 GO:0070990 snRNP binding 1/1602 11/18639 0.0909090909090909 1.05771195097038 0.627989569828373 0.841070017373722 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 1/1602 11/18639 0.0909090909090909 1.05771195097038 0.627989569828373 0.841070017373722 GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 1/1602 11/18639 0.0909090909090909 1.05771195097038 0.627989569828373 0.841070017373722 GO:1900750 oligopeptide binding 1/1602 11/18639 0.0909090909090909 1.05771195097038 0.627989569828373 0.841070017373722 GO:0008509 monoatomic anion transmembrane transporter activity 12/1602 149/18639 0.0805369127516778 0.937033406228791 0.636197618054878 0.851110012520843 GO:1901682 sulfur compound transmembrane transporter activity 5/1602 63/18639 0.0793650793650794 0.923399322275727 0.639600548521772 0.852588240787396 GO:0004197 cysteine-type endopeptidase activity 7/1602 88/18639 0.0795454545454545 0.925497957099081 0.640501456505016 0.852588240787396 GO:0015276 ligand-gated monoatomic ion channel activity 15/1602 186/18639 0.0806451612903226 0.938292859731787 0.640533904240036 0.852588240787396 GO:0005501 retinoid binding 3/1602 38/18639 0.0789473684210526 0.918539325842697 0.64555795581191 0.852588240787396 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 3/1602 38/18639 0.0789473684210526 0.918539325842697 0.64555795581191 0.852588240787396 GO:0019840 isoprenoid binding 3/1602 38/18639 0.0789473684210526 0.918539325842697 0.64555795581191 0.852588240787396 GO:0000030 mannosyltransferase activity 2/1602 25/18639 0.08 0.930786516853933 0.645856978389114 0.852588240787396 GO:0003707 nuclear steroid receptor activity 2/1602 25/18639 0.08 0.930786516853933 0.645856978389114 0.852588240787396 GO:0005251 delayed rectifier potassium channel activity 2/1602 25/18639 0.08 0.930786516853933 0.645856978389114 0.852588240787396 GO:0008483 transaminase activity 2/1602 25/18639 0.08 0.930786516853933 0.645856978389114 0.852588240787396 GO:0015296 monoatomic anion:monoatomic cation symporter activity 2/1602 25/18639 0.08 0.930786516853933 0.645856978389114 0.852588240787396 GO:0120020 cholesterol transfer activity 2/1602 25/18639 0.08 0.930786516853933 0.645856978389114 0.852588240787396 GO:0005048 signal sequence binding 4/1602 51/18639 0.0784313725490196 0.912535800837189 0.648896637099634 0.854714072655464 GO:0005272 sodium channel activity 4/1602 51/18639 0.0784313725490196 0.912535800837189 0.648896637099634 0.854714072655464 GO:0022834 ligand-gated channel activity 15/1602 188/18639 0.0797872340425532 0.92831102079847 0.65696923756251 0.857976999176897 GO:0004000 adenosine deaminase activity 1/1602 12/18639 0.0833333333333333 0.969569288389513 0.659982307059151 0.857976999176897 GO:0005247 voltage-gated chloride channel activity 1/1602 12/18639 0.0833333333333333 0.969569288389513 0.659982307059151 0.857976999176897 GO:0008504 monoamine transmembrane transporter activity 1/1602 12/18639 0.0833333333333333 0.969569288389513 0.659982307059151 0.857976999176897 GO:0015132 prostaglandin transmembrane transporter activity 1/1602 12/18639 0.0833333333333333 0.969569288389513 0.659982307059151 0.857976999176897 GO:0016273 arginine N-methyltransferase activity 1/1602 12/18639 0.0833333333333333 0.969569288389513 0.659982307059151 0.857976999176897 GO:0016274 protein-arginine N-methyltransferase activity 1/1602 12/18639 0.0833333333333333 0.969569288389513 0.659982307059151 0.857976999176897 GO:0016801 hydrolase activity, acting on ether bonds 1/1602 12/18639 0.0833333333333333 0.969569288389513 0.659982307059151 0.857976999176897 GO:0016803 ether hydrolase activity 1/1602 12/18639 0.0833333333333333 0.969569288389513 0.659982307059151 0.857976999176897 GO:0035251 UDP-glucosyltransferase activity 1/1602 12/18639 0.0833333333333333 0.969569288389513 0.659982307059151 0.857976999176897 GO:0070008 serine-type exopeptidase activity 1/1602 12/18639 0.0833333333333333 0.969569288389513 0.659982307059151 0.857976999176897 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 1/1602 12/18639 0.0833333333333333 0.969569288389513 0.659982307059151 0.857976999176897 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 3/1602 39/18639 0.0769230769230769 0.894987035436474 0.663137460851765 0.861142674461141 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 4/1602 52/18639 0.0769230769230769 0.894987035436474 0.664124725978365 0.861489340856969 GO:0004112 cyclic-nucleotide phosphodiesterase activity 2/1602 26/18639 0.0769230769230769 0.894987035436474 0.667235527653987 0.861785843492623 GO:0008198 ferrous iron binding 2/1602 26/18639 0.0769230769230769 0.894987035436474 0.667235527653987 0.861785843492623 GO:0015145 monosaccharide transmembrane transporter activity 2/1602 26/18639 0.0769230769230769 0.894987035436474 0.667235527653987 0.861785843492623 GO:0030247 polysaccharide binding 2/1602 26/18639 0.0769230769230769 0.894987035436474 0.667235527653987 0.861785843492623 GO:0005253 monoatomic anion channel activity 8/1602 103/18639 0.0776699029126214 0.903676229955274 0.669312209664812 0.862932900244784 GO:0015103 inorganic anion transmembrane transporter activity 13/1602 165/18639 0.0787878787878788 0.916683690840994 0.669566665072876 0.862932900244784 GO:0140097 catalytic activity, acting on DNA 27/1602 336/18639 0.0803571428571429 0.934941813804173 0.672354198473256 0.864742252936698 GO:0003774 cytoskeletal motor activity 12/1602 153/18639 0.0784313725490196 0.912535800837189 0.672416634808636 0.864742252936698 GO:1901505 carbohydrate derivative transmembrane transporter activity 4/1602 53/18639 0.0754716981132075 0.87810048759805 0.678895769709787 0.871777922318695 GO:0004532 RNA exonuclease activity 3/1602 40/18639 0.075 0.872612359550562 0.680074248765337 0.871777922318695 GO:0050997 quaternary ammonium group binding 3/1602 40/18639 0.075 0.872612359550562 0.680074248765337 0.871777922318695 GO:0005506 iron ion binding 12/1602 154/18639 0.0779220779220779 0.906610243688895 0.681141207760747 0.872210797089779 GO:0015370 solute:sodium symporter activity 6/1602 79/18639 0.0759493670886076 0.883658085620822 0.683095134832655 0.872289314231957 GO:0008320 protein transmembrane transporter activity 2/1602 27/18639 0.0740740740740741 0.861839367457345 0.687557979112055 0.872289314231957 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 2/1602 27/18639 0.0740740740740741 0.861839367457345 0.687557979112055 0.872289314231957 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 1/1602 13/18639 0.0769230769230769 0.894987035436474 0.689225252465886 0.872289314231957 GO:0004535 poly(A)-specific ribonuclease activity 1/1602 13/18639 0.0769230769230769 0.894987035436474 0.689225252465886 0.872289314231957 GO:0008253 5'-nucleotidase activity 1/1602 13/18639 0.0769230769230769 0.894987035436474 0.689225252465886 0.872289314231957 GO:0019104 DNA N-glycosylase activity 1/1602 13/18639 0.0769230769230769 0.894987035436474 0.689225252465886 0.872289314231957 GO:0031432 titin binding 1/1602 13/18639 0.0769230769230769 0.894987035436474 0.689225252465886 0.872289314231957 GO:0035673 oligopeptide transmembrane transporter activity 1/1602 13/18639 0.0769230769230769 0.894987035436474 0.689225252465886 0.872289314231957 GO:0089720 caspase binding 1/1602 13/18639 0.0769230769230769 0.894987035436474 0.689225252465886 0.872289314231957 GO:0140410 monoatomic cation:bicarbonate symporter activity 1/1602 13/18639 0.0769230769230769 0.894987035436474 0.689225252465886 0.872289314231957 GO:0050661 NADP binding 4/1602 54/18639 0.0740740740740741 0.861839367457345 0.693206881318737 0.875475638919967 GO:0051287 NAD binding 4/1602 54/18639 0.0740740740740741 0.861839367457345 0.693206881318737 0.875475638919967 GO:0022853 active monoatomic ion transmembrane transporter activity 9/1602 118/18639 0.076271186440678 0.887402399542944 0.694253884612981 0.875873044300765 GO:0001530 lipopolysaccharide binding 3/1602 41/18639 0.0731707317073171 0.851329131268841 0.696369714256165 0.87669281921092 GO:0061650 ubiquitin-like protein conjugating enzyme activity 3/1602 41/18639 0.0731707317073171 0.851329131268841 0.696369714256165 0.87669281921092 GO:0005262 calcium channel activity 10/1602 131/18639 0.0763358778625954 0.888155073333905 0.698313124848234 0.878215033983689 GO:0030246 carbohydrate binding 22/1602 280/18639 0.0785714285714286 0.914165329052969 0.70220473535376 0.882181579288968 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 5/1602 68/18639 0.0735294117647059 0.855502313284864 0.705743758188779 0.882764661900567 GO:0015101 organic cation transmembrane transporter activity 6/1602 81/18639 0.0740740740740741 0.861839367457345 0.706345438800113 0.882764661900567 GO:0050698 proteoglycan sulfotransferase activity 2/1602 28/18639 0.0714285714285714 0.831059390048154 0.70684782869943 0.882764661900567 GO:0051119 sugar transmembrane transporter activity 2/1602 28/18639 0.0714285714285714 0.831059390048154 0.70684782869943 0.882764661900567 GO:0051537 2 iron, 2 sulfur cluster binding 2/1602 28/18639 0.0714285714285714 0.831059390048154 0.70684782869943 0.882764661900567 GO:0008307 structural constituent of muscle 3/1602 42/18639 0.0714285714285714 0.831059390048154 0.712027961673205 0.882764661900567 GO:0031492 nucleosomal DNA binding 3/1602 42/18639 0.0714285714285714 0.831059390048154 0.712027961673205 0.882764661900567 GO:0005313 L-glutamate transmembrane transporter activity 1/1602 14/18639 0.0714285714285714 0.831059390048154 0.71595461709327 0.882764661900567 GO:0008331 high voltage-gated calcium channel activity 1/1602 14/18639 0.0714285714285714 0.831059390048154 0.71595461709327 0.882764661900567 GO:0008494 translation activator activity 1/1602 14/18639 0.0714285714285714 0.831059390048154 0.71595461709327 0.882764661900567 GO:0015386 potassium:proton antiporter activity 1/1602 14/18639 0.0714285714285714 0.831059390048154 0.71595461709327 0.882764661900567 GO:0019992 diacylglycerol binding 1/1602 14/18639 0.0714285714285714 0.831059390048154 0.71595461709327 0.882764661900567 GO:0032036 myosin heavy chain binding 1/1602 14/18639 0.0714285714285714 0.831059390048154 0.71595461709327 0.882764661900567 GO:0034236 protein kinase A catalytic subunit binding 1/1602 14/18639 0.0714285714285714 0.831059390048154 0.71595461709327 0.882764661900567 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 1/1602 14/18639 0.0714285714285714 0.831059390048154 0.71595461709327 0.882764661900567 GO:0043176 amine binding 1/1602 14/18639 0.0714285714285714 0.831059390048154 0.71595461709327 0.882764661900567 GO:0071933 Arp2/3 complex binding 1/1602 14/18639 0.0714285714285714 0.831059390048154 0.71595461709327 0.882764661900567 GO:1901474 azole transmembrane transporter activity 1/1602 14/18639 0.0714285714285714 0.831059390048154 0.71595461709327 0.882764661900567 GO:0008080 N-acetyltransferase activity 5/1602 69/18639 0.072463768115942 0.843103729034359 0.717897332902371 0.884248414161932 GO:0043236 laminin binding 2/1602 29/18639 0.0689655172413793 0.802402169701666 0.725132335228351 0.892241021536119 GO:0005245 voltage-gated calcium channel activity 3/1602 43/18639 0.0697674418604651 0.811732427488895 0.727055484073301 0.893687933146627 GO:0005254 chloride channel activity 6/1602 83/18639 0.072289156626506 0.841072153783674 0.728408837551311 0.89443220709586 GO:0008028 monocarboxylic acid transmembrane transporter activity 5/1602 70/18639 0.0714285714285714 0.831059390048154 0.729689305918693 0.895085548593596 GO:0140104 molecular carrier activity 19/1602 249/18639 0.0763052208835341 0.887798384549434 0.739842510255483 0.901482511865951 GO:0008020 G protein-coupled photoreceptor activity 1/1602 15/18639 0.0666666666666667 0.77565543071161 0.740386332712952 0.901482511865951 GO:0008252 nucleotidase activity 1/1602 15/18639 0.0666666666666667 0.77565543071161 0.740386332712952 0.901482511865951 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 1/1602 15/18639 0.0666666666666667 0.77565543071161 0.740386332712952 0.901482511865951 GO:0045504 dynein heavy chain binding 1/1602 15/18639 0.0666666666666667 0.77565543071161 0.740386332712952 0.901482511865951 GO:0047372 monoacylglycerol lipase activity 1/1602 15/18639 0.0666666666666667 0.77565543071161 0.740386332712952 0.901482511865951 GO:0030547 signaling receptor inhibitor activity 3/1602 44/18639 0.0681818181818182 0.793283963227783 0.741460864097435 0.901482511865951 GO:0016769 transferase activity, transferring nitrogenous groups 2/1602 30/18639 0.0666666666666667 0.77565543071161 0.742441700826055 0.901482511865951 GO:0033612 receptor serine/threonine kinase binding 2/1602 30/18639 0.0666666666666667 0.77565543071161 0.742441700826055 0.901482511865951 GO:0048019 receptor antagonist activity 2/1602 30/18639 0.0666666666666667 0.77565543071161 0.742441700826055 0.901482511865951 GO:0003730 mRNA 3'-UTR binding 20/1602 262/18639 0.0763358778625954 0.888155073333905 0.743256824678474 0.901556959751982 GO:0005267 potassium channel activity 9/1602 124/18639 0.0725806451612903 0.844463573758608 0.748659567376663 0.907190316699583 GO:0005184 neuropeptide hormone activity 2/1602 31/18639 0.0645161290322581 0.75063428778543 0.758808364312096 0.913123602656892 GO:0005452 solute:inorganic anion antiporter activity 2/1602 31/18639 0.0645161290322581 0.75063428778543 0.758808364312096 0.913123602656892 GO:0016411 acylglycerol O-acyltransferase activity 2/1602 31/18639 0.0645161290322581 0.75063428778543 0.758808364312096 0.913123602656892 GO:0015081 sodium ion transmembrane transporter activity 12/1602 164/18639 0.0731707317073171 0.851329131268841 0.760577717078494 0.913123602656892 GO:0000062 fatty-acyl-CoA binding 1/1602 16/18639 0.0625 0.727176966292135 0.762717791851367 0.913123602656892 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 1/1602 16/18639 0.0625 0.727176966292135 0.762717791851367 0.913123602656892 GO:0015385 sodium:proton antiporter activity 1/1602 16/18639 0.0625 0.727176966292135 0.762717791851367 0.913123602656892 GO:0016722 oxidoreductase activity, acting on metal ions 1/1602 16/18639 0.0625 0.727176966292135 0.762717791851367 0.913123602656892 GO:0017070 U6 snRNA binding 1/1602 16/18639 0.0625 0.727176966292135 0.762717791851367 0.913123602656892 GO:0022841 potassium ion leak channel activity 1/1602 16/18639 0.0625 0.727176966292135 0.762717791851367 0.913123602656892 GO:0030275 LRR domain binding 1/1602 16/18639 0.0625 0.727176966292135 0.762717791851367 0.913123602656892 GO:0097027 ubiquitin-protein transferase activator activity 1/1602 16/18639 0.0625 0.727176966292135 0.762717791851367 0.913123602656892 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 4/1602 60/18639 0.0666666666666667 0.77565543071161 0.769455868080586 0.919158791530018 GO:0022884 macromolecule transmembrane transporter activity 2/1602 32/18639 0.0625 0.727176966292135 0.774266394173245 0.919158791530018 GO:0030515 snoRNA binding 2/1602 32/18639 0.0625 0.727176966292135 0.774266394173245 0.919158791530018 GO:0120015 sterol transfer activity 2/1602 32/18639 0.0625 0.727176966292135 0.774266394173245 0.919158791530018 GO:0160041 neuropeptide activity 2/1602 32/18639 0.0625 0.727176966292135 0.774266394173245 0.919158791530018 GO:0016651 oxidoreductase activity, acting on NAD(P)H 6/1602 88/18639 0.0681818181818182 0.793283963227783 0.77836088447136 0.919158791530018 GO:0016836 hydro-lyase activity 4/1602 61/18639 0.0655737704918033 0.76293976791306 0.78059593781411 0.919158791530018 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 1/1602 17/18639 0.0588235294117647 0.684401850627892 0.783129438602917 0.919158791530018 GO:0009881 photoreceptor activity 1/1602 17/18639 0.0588235294117647 0.684401850627892 0.783129438602917 0.919158791530018 GO:0015347 sodium-independent organic anion transmembrane transporter activity 1/1602 17/18639 0.0588235294117647 0.684401850627892 0.783129438602917 0.919158791530018 GO:0016018 cyclosporin A binding 1/1602 17/18639 0.0588235294117647 0.684401850627892 0.783129438602917 0.919158791530018 GO:0016805 dipeptidase activity 1/1602 17/18639 0.0588235294117647 0.684401850627892 0.783129438602917 0.919158791530018 GO:0030169 low-density lipoprotein particle binding 1/1602 17/18639 0.0588235294117647 0.684401850627892 0.783129438602917 0.919158791530018 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 1/1602 17/18639 0.0588235294117647 0.684401850627892 0.783129438602917 0.919158791530018 GO:0032183 SUMO binding 1/1602 17/18639 0.0588235294117647 0.684401850627892 0.783129438602917 0.919158791530018 GO:0048038 quinone binding 1/1602 17/18639 0.0588235294117647 0.684401850627892 0.783129438602917 0.919158791530018 GO:0051787 misfolded protein binding 1/1602 17/18639 0.0588235294117647 0.684401850627892 0.783129438602917 0.919158791530018 GO:0070402 NADPH binding 1/1602 17/18639 0.0588235294117647 0.684401850627892 0.783129438602917 0.919158791530018 GO:0070492 oligosaccharide binding 1/1602 17/18639 0.0588235294117647 0.684401850627892 0.783129438602917 0.919158791530018 GO:1901567 fatty acid derivative binding 1/1602 17/18639 0.0588235294117647 0.684401850627892 0.783129438602917 0.919158791530018 GO:0019239 deaminase activity 2/1602 33/18639 0.0606060606060606 0.705141300646919 0.788850969251917 0.924966430613032 GO:0140375 immune receptor activity 11/1602 156/18639 0.0705128205128205 0.820404782483434 0.794685818672151 0.930895434996956 GO:0008308 voltage-gated monoatomic anion channel activity 1/1602 18/18639 0.0555555555555556 0.646379525593009 0.80178622301695 0.934671014738871 GO:0015280 ligand-gated sodium channel activity 1/1602 18/18639 0.0555555555555556 0.646379525593009 0.80178622301695 0.934671014738871 GO:0016854 racemase and epimerase activity 1/1602 18/18639 0.0555555555555556 0.646379525593009 0.80178622301695 0.934671014738871 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 1/1602 18/18639 0.0555555555555556 0.646379525593009 0.80178622301695 0.934671014738871 GO:0015035 protein-disulfide reductase activity 2/1602 34/18639 0.0588235294117647 0.684401850627892 0.802597936569248 0.934671014738871 GO:0019825 oxygen binding 2/1602 34/18639 0.0588235294117647 0.684401850627892 0.802597936569248 0.934671014738871 GO:0015605 organophosphate ester transmembrane transporter activity 3/1602 50/18639 0.06 0.698089887640449 0.815506483593613 0.938851896816423 GO:0000175 3'-5'-RNA exonuclease activity 2/1602 35/18639 0.0571428571428571 0.664847512038523 0.815543436872786 0.938851896816423 GO:0034061 DNA polymerase activity 2/1602 35/18639 0.0571428571428571 0.664847512038523 0.815543436872786 0.938851896816423 GO:0003756 protein disulfide isomerase activity 1/1602 19/18639 0.0526315789473684 0.612359550561798 0.818838930751596 0.938851896816423 GO:0008301 DNA binding, bending 1/1602 19/18639 0.0526315789473684 0.612359550561798 0.818838930751596 0.938851896816423 GO:0008381 mechanosensitive monoatomic ion channel activity 1/1602 19/18639 0.0526315789473684 0.612359550561798 0.818838930751596 0.938851896816423 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 1/1602 19/18639 0.0526315789473684 0.612359550561798 0.818838930751596 0.938851896816423 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 1/1602 19/18639 0.0526315789473684 0.612359550561798 0.818838930751596 0.938851896816423 GO:0016918 retinal binding 1/1602 19/18639 0.0526315789473684 0.612359550561798 0.818838930751596 0.938851896816423 GO:0022821 solute:potassium antiporter activity 1/1602 19/18639 0.0526315789473684 0.612359550561798 0.818838930751596 0.938851896816423 GO:0022840 leak channel activity 1/1602 19/18639 0.0526315789473684 0.612359550561798 0.818838930751596 0.938851896816423 GO:0022842 narrow pore channel activity 1/1602 19/18639 0.0526315789473684 0.612359550561798 0.818838930751596 0.938851896816423 GO:0031420 alkali metal ion binding 1/1602 19/18639 0.0526315789473684 0.612359550561798 0.818838930751596 0.938851896816423 GO:0042834 peptidoglycan binding 1/1602 19/18639 0.0526315789473684 0.612359550561798 0.818838930751596 0.938851896816423 GO:0043395 heparan sulfate proteoglycan binding 1/1602 19/18639 0.0526315789473684 0.612359550561798 0.818838930751596 0.938851896816423 GO:0046527 glucosyltransferase activity 1/1602 19/18639 0.0526315789473684 0.612359550561798 0.818838930751596 0.938851896816423 GO:0016835 carbon-oxygen lyase activity 5/1602 79/18639 0.0632911392405063 0.736381738017352 0.819914734574569 0.938851896816423 GO:0015079 potassium ion transmembrane transporter activity 11/1602 160/18639 0.06875 0.799894662921348 0.820317919877226 0.938851896816423 GO:0016597 amino acid binding 3/1602 51/18639 0.0588235294117647 0.684401850627892 0.825919598999487 0.942816583900737 GO:0030544 Hsp70 protein binding 3/1602 51/18639 0.0588235294117647 0.684401850627892 0.825919598999487 0.942816583900737 GO:0015108 chloride transmembrane transporter activity 8/1602 121/18639 0.0661157024793388 0.769245055251184 0.826559044236083 0.942816583900737 GO:0004869 cysteine-type endopeptidase inhibitor activity 2/1602 36/18639 0.0555555555555556 0.646379525593009 0.827723589544962 0.942816583900737 GO:0055106 ubiquitin-protein transferase regulator activity 2/1602 36/18639 0.0555555555555556 0.646379525593009 0.827723589544962 0.942816583900737 GO:0016410 N-acyltransferase activity 6/1602 94/18639 0.0638297872340425 0.742648816638776 0.82876297198141 0.943102297326133 GO:0005326 neurotransmitter transmembrane transporter activity 1/1602 20/18639 0.05 0.581741573033708 0.834425398685858 0.946843241772567 GO:0016505 peptidase activator activity involved in apoptotic process 1/1602 20/18639 0.05 0.581741573033708 0.834425398685858 0.946843241772567 GO:0140664 ATP-dependent DNA damage sensor activity 1/1602 20/18639 0.05 0.581741573033708 0.834425398685858 0.946843241772567 GO:0099094 ligand-gated monoatomic cation channel activity 9/1602 136/18639 0.0661764705882353 0.769952081956378 0.836386548933178 0.948169016610504 GO:0019213 deacetylase activity 2/1602 37/18639 0.0540540540540541 0.62890980868509 0.839174229444609 0.949529213259936 GO:0030551 cyclic nucleotide binding 2/1602 37/18639 0.0540540540540541 0.62890980868509 0.839174229444609 0.949529213259936 GO:0016860 intramolecular oxidoreductase activity 3/1602 53/18639 0.0566037735849057 0.658575365698537 0.845241185822322 0.954855376306238 GO:0001846 opsonin binding 1/1602 21/18639 0.0476190476190476 0.554039593365436 0.848671626265494 0.954855376306238 GO:0015125 bile acid transmembrane transporter activity 1/1602 21/18639 0.0476190476190476 0.554039593365436 0.848671626265494 0.954855376306238 GO:0019200 carbohydrate kinase activity 1/1602 21/18639 0.0476190476190476 0.554039593365436 0.848671626265494 0.954855376306238 GO:0061891 calcium ion sensor activity 1/1602 21/18639 0.0476190476190476 0.554039593365436 0.848671626265494 0.954855376306238 GO:1904047 S-adenosyl-L-methionine binding 1/1602 21/18639 0.0476190476190476 0.554039593365436 0.848671626265494 0.954855376306238 GO:0005249 voltage-gated potassium channel activity 6/1602 98/18639 0.0612244897959184 0.712336620041275 0.85696136058279 0.963276115843061 GO:0008649 rRNA methyltransferase activity 1/1602 22/18639 0.0454545454545455 0.528855975485189 0.861692791520768 0.966777278291593 GO:0140784 metal ion sensor activity 1/1602 22/18639 0.0454545454545455 0.528855975485189 0.861692791520768 0.966777278291593 GO:0015036 disulfide oxidoreductase activity 2/1602 40/18639 0.05 0.581741573033708 0.869498850430285 0.972188405409318 GO:0015144 carbohydrate transmembrane transporter activity 2/1602 40/18639 0.05 0.581741573033708 0.869498850430285 0.972188405409318 GO:0071855 neuropeptide receptor binding 2/1602 40/18639 0.05 0.581741573033708 0.869498850430285 0.972188405409318 GO:0140299 molecular sensor activity 4/1602 71/18639 0.0563380281690141 0.655483462573192 0.869767218886262 0.972188405409318 GO:0016209 antioxidant activity 5/1602 86/18639 0.0581395348837209 0.676443689574079 0.871877987348216 0.973637789793152 GO:0016849 phosphorus-oxygen lyase activity 1/1602 23/18639 0.0434782608695652 0.505862237420616 0.873594179928338 0.973735917236059 GO:0140102 catalytic activity, acting on a rRNA 1/1602 23/18639 0.0434782608695652 0.505862237420616 0.873594179928338 0.973735917236059 GO:0042379 chemokine receptor binding 4/1602 72/18639 0.0555555555555556 0.646379525593009 0.87668341160064 0.974526170810112 GO:0008081 phosphoric diester hydrolase activity 5/1602 87/18639 0.0574712643678161 0.668668474751388 0.878153390356088 0.974526170810112 GO:0004601 peroxidase activity 3/1602 57/18639 0.0526315789473684 0.612359550561798 0.878353367614555 0.974526170810112 GO:0015932 nucleobase-containing compound transmembrane transporter activity 3/1602 57/18639 0.0526315789473684 0.612359550561798 0.878353367614555 0.974526170810112 GO:0042287 MHC protein binding 2/1602 41/18639 0.0487804878048781 0.567552754179227 0.878377267669984 0.974526170810112 GO:0009055 electron transfer activity 7/1602 116/18639 0.0603448275862069 0.702101898488958 0.879893770814612 0.975303938734268 GO:0019957 C-C chemokine binding 1/1602 24/18639 0.0416666666666667 0.484784644194757 0.884472033589425 0.978564803120215 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 1/1602 24/18639 0.0416666666666667 0.484784644194757 0.884472033589425 0.978564803120215 GO:0005244 voltage-gated monoatomic ion channel activity 11/1602 173/18639 0.0635838150289017 0.739786971487952 0.887048898919935 0.980508764425363 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 8/1602 132/18639 0.0606060606060606 0.705141300646919 0.889439681881472 0.982243637608717 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 3/1602 59/18639 0.0508474576271186 0.591601599695296 0.892421964265824 0.983198102717924 GO:0001848 complement binding 1/1602 25/18639 0.04 0.465393258426966 0.894414327556105 0.983198102717924 GO:0005537 D-mannose binding 1/1602 25/18639 0.04 0.465393258426966 0.894414327556105 0.983198102717924 GO:0017056 structural constituent of nuclear pore 1/1602 25/18639 0.04 0.465393258426966 0.894414327556105 0.983198102717924 GO:0047617 fatty acyl-CoA hydrolase activity 1/1602 25/18639 0.04 0.465393258426966 0.894414327556105 0.983198102717924 GO:0022832 voltage-gated channel activity 11/1602 175/18639 0.0628571428571429 0.731332263242376 0.895252675134515 0.983215977466373 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 3/1602 60/18639 0.05 0.581741573033708 0.898893864065047 0.98396846193046 GO:0016790 thiolester hydrolase activity 2/1602 44/18639 0.0454545454545455 0.528855975485189 0.901768734799341 0.98396846193046 GO:0004497 monooxygenase activity 6/1602 106/18639 0.0566037735849057 0.658575365698537 0.90191755744403 0.98396846193046 GO:0004435 phosphatidylinositol phospholipase C activity 1/1602 26/18639 0.0384615384615385 0.447493517718237 0.903501479552189 0.98396846193046 GO:0005227 calcium-activated cation channel activity 1/1602 26/18639 0.0384615384615385 0.447493517718237 0.903501479552189 0.98396846193046 GO:0016289 acyl-CoA hydrolase activity 1/1602 26/18639 0.0384615384615385 0.447493517718237 0.903501479552189 0.98396846193046 GO:0019865 immunoglobulin binding 1/1602 26/18639 0.0384615384615385 0.447493517718237 0.903501479552189 0.98396846193046 GO:0051139 metal cation:proton antiporter activity 1/1602 26/18639 0.0384615384615385 0.447493517718237 0.903501479552189 0.98396846193046 GO:0097602 cullin family protein binding 1/1602 26/18639 0.0384615384615385 0.447493517718237 0.903501479552189 0.98396846193046 GO:0004540 RNA nuclease activity 7/1602 121/18639 0.0578512396694215 0.673089423344786 0.904164999717036 0.98396846193046 GO:0052689 carboxylic ester hydrolase activity 5/1602 92/18639 0.0543478260869565 0.632327796775769 0.905731479727376 0.984777136139947 GO:0016779 nucleotidyltransferase activity 8/1602 136/18639 0.0588235294117647 0.684401850627892 0.907007710371392 0.985191012913048 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 7/1602 122/18639 0.0573770491803279 0.667572296923927 0.908481964687537 0.985191012913048 GO:0008009 chemokine activity 2/1602 45/18639 0.0444444444444444 0.517103620474407 0.908583350537702 0.985191012913048 GO:0004683 calcium/calmodulin-dependent protein kinase activity 1/1602 27/18639 0.037037037037037 0.430919683728672 0.911806998799887 0.986004675013259 GO:0005385 zinc ion transmembrane transporter activity 1/1602 27/18639 0.037037037037037 0.430919683728672 0.911806998799887 0.986004675013259 GO:0015252 proton channel activity 1/1602 27/18639 0.037037037037037 0.430919683728672 0.911806998799887 0.986004675013259 GO:0016853 isomerase activity 11/1602 180/18639 0.0611111111111111 0.71101747815231 0.91363063364384 0.986730330449133 GO:0004180 carboxypeptidase activity 2/1602 46/18639 0.0434782608695652 0.505862237420616 0.914953124137198 0.986730330449133 GO:0030291 protein serine/threonine kinase inhibitor activity 2/1602 46/18639 0.0434782608695652 0.505862237420616 0.914953124137198 0.986730330449133 GO:0005507 copper ion binding 3/1602 63/18639 0.0476190476190476 0.554039593365436 0.916254752538277 0.987243859491693 GO:0005242 inward rectifier potassium channel activity 1/1602 28/18639 0.0357142857142857 0.415529695024077 0.919398079173978 0.9888490132123 GO:0016866 intramolecular transferase activity 1/1602 28/18639 0.0357142857142857 0.415529695024077 0.919398079173978 0.9888490132123 GO:0022836 gated channel activity 21/1602 318/18639 0.0660377358490566 0.768337926648293 0.920363406061251 0.988997873898703 GO:0016407 acetyltransferase activity 5/1602 96/18639 0.0520833333333333 0.605980805243446 0.923706008877955 0.990212354691811 GO:0160215 deacylase activity 3/1602 65/18639 0.0461538461538462 0.536992221261884 0.926270743080544 0.990212354691811 GO:0004181 metallocarboxypeptidase activity 1/1602 29/18639 0.0344827586206897 0.401201084850833 0.92633614145775 0.990212354691811 GO:0004629 phospholipase C activity 1/1602 29/18639 0.0344827586206897 0.401201084850833 0.92633614145775 0.990212354691811 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 2/1602 48/18639 0.0416666666666667 0.484784644194757 0.92646122483289 0.990212354691811 GO:0038187 pattern recognition receptor activity 2/1602 48/18639 0.0416666666666667 0.484784644194757 0.92646122483289 0.990212354691811 GO:0022843 voltage-gated monoatomic cation channel activity 8/1602 143/18639 0.0559440559440559 0.650899662135617 0.932057798396123 0.995077685604482 GO:0022839 monoatomic ion-gated channel activity 1/1602 30/18639 0.0333333333333333 0.387827715355805 0.93267732906574 0.995077685604482 GO:0032813 tumor necrosis factor receptor superfamily binding 2/1602 50/18639 0.04 0.465393258426966 0.936487360018481 0.996814974799411 GO:0048020 CCR chemokine receptor binding 2/1602 50/18639 0.04 0.465393258426966 0.936487360018481 0.996814974799411 GO:0016798 hydrolase activity, acting on glycosyl bonds 7/1602 130/18639 0.0538461538461538 0.626490924805532 0.937378014689826 0.996814974799411 GO:0004527 exonuclease activity 4/1602 84/18639 0.0476190476190476 0.554039593365436 0.937770269856883 0.996814974799411 GO:0072349 modified amino acid transmembrane transporter activity 1/1602 31/18639 0.032258064516129 0.375317143892715 0.938472961224194 0.996814974799411 GO:0015294 solute:monoatomic cation symporter activity 6/1602 116/18639 0.0517241379310345 0.60180162727625 0.940575672201049 0.998161937846011 GO:0005179 hormone activity 7/1602 132/18639 0.053030303030303 0.616998638066054 0.943206545029022 0.999777552631251 GO:0015106 bicarbonate transmembrane transporter activity 1/1602 32/18639 0.03125 0.363588483146067 0.943769947258096 0.999777552631251 GO:0005125 cytokine activity 14/1602 234/18639 0.0598290598290598 0.696101027561702 0.945949978504136 0.999999995950887 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 2/1602 54/18639 0.037037037037037 0.430919683728672 0.952779228621237 0.999999995950887 GO:0017069 snRNA binding 2/1602 54/18639 0.037037037037037 0.430919683728672 0.952779228621237 0.999999995950887 GO:0008175 tRNA methyltransferase activity 1/1602 34/18639 0.0294117647058824 0.342200925313946 0.95303580861629 0.999999995950887 GO:0015020 glucuronosyltransferase activity 1/1602 34/18639 0.0294117647058824 0.342200925313946 0.95303580861629 0.999999995950887 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 1/1602 34/18639 0.0294117647058824 0.342200925313946 0.95303580861629 0.999999995950887 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 1/1602 34/18639 0.0294117647058824 0.342200925313946 0.95303580861629 0.999999995950887 GO:0016874 ligase activity 9/1602 167/18639 0.0538922155688623 0.627026845186032 0.955716790521993 0.999999995950887 GO:0008374 O-acyltransferase activity 2/1602 55/18639 0.0363636363636364 0.423084780388151 0.956179482427769 0.999999995950887 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 4/1602 91/18639 0.043956043956044 0.511421163106556 0.95914234495328 0.999999995950887 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 1/1602 36/18639 0.0277777777777778 0.323189762796504 0.960775590827375 0.999999995950887 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 1/1602 36/18639 0.0277777777777778 0.323189762796504 0.960775590827375 0.999999995950887 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 1/1602 36/18639 0.0277777777777778 0.323189762796504 0.960775590827375 0.999999995950887 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 1/1602 36/18639 0.0277777777777778 0.323189762796504 0.960775590827375 0.999999995950887 GO:0015078 proton transmembrane transporter activity 10/1602 185/18639 0.0540540540540541 0.62890980868509 0.961795431840645 0.999999995950887 GO:0005261 monoatomic cation channel activity 21/1602 341/18639 0.06158357771261 0.716514547431546 0.962306997892649 0.999999995950887 GO:0004620 phospholipase activity 5/1602 109/18639 0.0458715596330275 0.533707865168539 0.96292792873052 0.999999995950887 GO:0022829 wide pore channel activity 1/1602 37/18639 0.027027027027027 0.314454904342545 0.964153406421341 0.999999995950887 GO:0051536 iron-sulfur cluster binding 3/1602 76/18639 0.0394736842105263 0.459269662921348 0.96422203541971 0.999999995950887 GO:0008408 3'-5' exonuclease activity 2/1602 58/18639 0.0344827586206897 0.401201084850833 0.965029275720964 0.999999995950887 GO:0051540 metal cluster binding 3/1602 77/18639 0.038961038961039 0.453305121844448 0.966554892038543 0.999999995950887 GO:0042887 amide transmembrane transporter activity 1/1602 38/18639 0.0263157894736842 0.306179775280899 0.967240506889732 0.999999995950887 GO:0022804 active transmembrane transporter activity 29/1602 457/18639 0.0634573304157549 0.73831534433162 0.970047033599106 0.999999995950887 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 1/1602 39/18639 0.0256410256410256 0.298329011812158 0.970061898640856 0.999999995950887 GO:0016776 phosphotransferase activity, phosphate group as acceptor 1/1602 39/18639 0.0256410256410256 0.298329011812158 0.970061898640856 0.999999995950887 GO:0015293 symporter activity 7/1602 146/18639 0.0479452054794521 0.557834385100816 0.972157377213087 0.999999995950887 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 1/1602 40/18639 0.025 0.290870786516854 0.972640438338563 0.999999995950887 GO:0061791 GTPase motor activity 1/1602 40/18639 0.025 0.290870786516854 0.972640438338563 0.999999995950887 GO:1990606 membrane scission GTPase motor activity 1/1602 40/18639 0.025 0.290870786516854 0.972640438338563 0.999999995950887 GO:0005216 monoatomic ion channel activity 28/1602 448/18639 0.0625 0.727176966292135 0.974072246137138 0.999999995950887 GO:0140828 metal cation:monoatomic cation antiporter activity 1/1602 41/18639 0.024390243902439 0.283776377089614 0.974997017605277 0.999999995950887 GO:0046873 metal ion transmembrane transporter activity 28/1602 450/18639 0.0622222222222222 0.72394506866417 0.975692174970259 0.999999995950887 GO:0016859 cis-trans isomerase activity 1/1602 42/18639 0.0238095238095238 0.277019796682718 0.977150731864679 0.999999995950887 GO:0015297 antiporter activity 6/1602 135/18639 0.0444444444444444 0.517103620474407 0.97875395434507 0.999999995950887 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1/1602 43/18639 0.0232558139534884 0.270577475829632 0.979119034685176 0.999999995950887 GO:0019843 rRNA binding 2/1602 65/18639 0.0307692307692308 0.357994814174589 0.979492554271374 0.999999995950887 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 12/1602 229/18639 0.0524017467248908 0.609685491389039 0.980012309940022 0.999999995950887 GO:0019205 nucleobase-containing compound kinase activity 1/1602 44/18639 0.0227272727272727 0.264427987742595 0.980917878868567 0.999999995950887 GO:0008173 RNA methyltransferase activity 2/1602 67/18639 0.0298507462686567 0.347308401811169 0.982422811854662 0.999999995950887 GO:0051539 4 iron, 4 sulfur cluster binding 1/1602 45/18639 0.0222222222222222 0.258551810237203 0.982561845421541 0.999999995950887 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 1/1602 46/18639 0.0217391304347826 0.252931118710308 0.984064261450082 0.999999995950887 GO:0016879 ligase activity, forming carbon-nitrogen bonds 1/1602 48/18639 0.0208333333333333 0.242392322097378 0.986692118206237 0.999999995950887 GO:0016298 lipase activity 5/1602 130/18639 0.0384615384615385 0.447493517718237 0.989457488742879 0.999999995950887 GO:0016830 carbon-carbon lyase activity 1/1602 51/18639 0.0196078431372549 0.228133950209297 0.989844588589039 0.999999995950887 GO:0004864 protein phosphatase inhibitor activity 1/1602 53/18639 0.0188679245283019 0.219525121899512 0.991519680198994 0.999999995950887 GO:0016251 RNA polymerase II general transcription initiation factor activity 1/1602 53/18639 0.0188679245283019 0.219525121899512 0.991519680198994 0.999999995950887 GO:0140098 catalytic activity, acting on RNA 21/1602 387/18639 0.0542635658914729 0.631347443602474 0.993300624545145 0.999999995950887 GO:0019212 phosphatase inhibitor activity 1/1602 56/18639 0.0178571428571429 0.207764847512039 0.993529054196025 0.999999995950887 GO:0030170 pyridoxal phosphate binding 1/1602 56/18639 0.0178571428571429 0.207764847512039 0.993529054196025 0.999999995950887 GO:0070279 vitamin B6 binding 1/1602 57/18639 0.0175438596491228 0.204119850187266 0.994086900355308 0.999999995950887 GO:0020037 heme binding 5/1602 142/18639 0.0352112676056338 0.409677164108245 0.995067370373868 0.999999995950887 GO:0016829 lyase activity 8/1602 200/18639 0.04 0.465393258426966 0.996529307611144 0.999999995950887 GO:0019842 vitamin binding 5/1602 150/18639 0.0333333333333333 0.387827715355805 0.997068149945044 0.999999995950887 GO:0015291 secondary active transmembrane transporter activity 13/1602 287/18639 0.0452961672473868 0.527013271737854 0.997411124716975 0.999999995950887 GO:0046906 tetrapyrrole binding 5/1602 152/18639 0.0328947368421053 0.382724719101124 0.997429793452118 0.999999995950887 GO:0140223 general transcription initiation factor activity 1/1602 68/18639 0.0147058823529412 0.171100462656973 0.997807238464927 0.999999995950887 GO:0004518 nuclease activity 8/1602 209/18639 0.0382775119617225 0.44535240040858 0.997944163373081 0.999999995950887 GO:0003823 antigen binding 6/1602 174/18639 0.0344827586206897 0.401201084850833 0.997973937833641 0.999999995950887 GO:0140101 catalytic activity, acting on a tRNA 4/1602 139/18639 0.0287769784172662 0.33481529383235 0.998308205178581 0.999999995950887 GO:0004521 RNA endonuclease activity 1/1602 73/18639 0.0136986301369863 0.159381252885947 0.998603393300074 0.999999995950887 GO:0001653 peptide receptor activity 3/1602 128/18639 0.0234375 0.272691362359551 0.999166393037517 0.999999995950887 GO:0000049 tRNA binding 1/1602 80/18639 0.0125 0.145435393258427 0.999257498827119 0.999999995950887 GO:0008528 G protein-coupled peptide receptor activity 2/1602 122/18639 0.0163934426229508 0.190734941978265 0.999790621266381 0.999999995950887 GO:0004519 endonuclease activity 1/1602 127/18639 0.0078740157480315 0.0916128461470406 0.999989391788015 0.999999995950887 GO:0003735 structural constituent of ribosome 1/1602 175/18639 0.00571428571428571 0.0664847512038523 0.99999986314413 0.999999995950887 GO:0030371 translation repressor activity 5/1602 329/18639 0.0151975683890578 0.176821146818756 0.999999994956738 0.999999995950887 GO:0045182 translation regulator activity 6/1602 356/18639 0.0168539325842697 0.196092665067542 0.999999995950887 0.999999995950887