category subcategory ID Description GeneRatio BgRatio FoldEnrichment geneName zScore Metabolism Carbohydrate metabolism hsa00010 Glycolysis / Gluconeogenesis 5/51 67/9376 13.7196371085748 ENO1/GAPDH/ALDOA/FBP1/PKM 7.72692885023649 Cellular Processes Transport and catabolism hsa04145 Phagosome 6/51 155/9376 7.11650853889943 ACTB/CORO1A/MARCO/ACTG1/HLA-DQB1/HLA-DQA1 5.67840978589425 Organismal Systems Immune system hsa04640 Hematopoietic cell lineage 5/51 100/9376 9.1921568627451 HLA-DQB1/CD1D/CD1C/CD1E/HLA-DQA1 6.09065774338635 Cellular Processes Cellular community - eukaryotes hsa04530 Tight junction 6/51 170/9376 6.48858131487889 ACTB/ACTG1/CD1D/CD1C/ACTR3/CD1E 5.34066557863396 Human Diseases Infectious disease: bacterial hsa05132 Salmonella infection 7/51 248/9376 5.18912080961417 ACTB/S100A10/ANXA2/PFN1/ACTG1/GAPDH/ACTR3 4.94432734297621 Metabolism Global and overview maps hsa01200 Carbon metabolism 5/51 116/9376 7.92427315753888 ENO1/GAPDH/ALDOA/FBP1/PKM 5.54937405560031 Human Diseases Cardiovascular disease hsa05416 Viral myocarditis 4/51 70/9376 10.5053221288515 ACTB/ACTG1/HLA-DQB1/HLA-DQA1 5.90310680936715 Metabolism Global and overview maps hsa01230 Biosynthesis of amino acids 4/51 75/9376 9.80496732026144 ENO1/GAPDH/ALDOA/PKM 5.661608882131 Genetic Information Processing Translation hsa03010 Ribosome 6/51 222/9376 4.96873343932167 RPS3A/RPSA/RPL29/RPL9/RPS18/RPS6 4.42557056210125 Human Diseases Infectious disease: viral hsa05171 Coronavirus disease - COVID-19 6/51 238/9376 4.63470093919921 RPS3A/RPSA/RPL29/RPL9/RPS18/RPS6 4.20027660027039 Human Diseases Infectious disease: viral hsa05164 Influenza A 5/51 173/9376 5.31338546979485 ACTB/ACTG1/HLA-DQB1/CCND3/HLA-DQA1 4.23470261968304 Human Diseases Infectious disease: bacterial hsa05152 Tuberculosis 5/51 181/9376 5.07853970317409 CORO1A/HLA-DQB1/VDR/HLA-DQA1/LSP1 4.09745715456571 Environmental Information Processing Signal transduction hsa04066 HIF-1 signaling pathway 4/51 110/9376 6.68520499108734 ENO1/GAPDH/ALDOA/RPS6 4.43550046681885 Human Diseases Infectious disease: viral hsa05166 Human T-cell leukemia virus 1 infection 5/51 224/9376 4.10364145658263 HLA-DQB1/RAN/TSPO/CCND3/HLA-DQA1 3.47683318152327 Cellular Processes Cell motility hsa04810 Regulation of actin cytoskeleton 5/51 232/9376 3.96213657876944 ACTB/PFN1/ACTG1/CFL1/ACTR3 3.37852602709901 Human Diseases Infectious disease: bacterial hsa05100 Bacterial invasion of epithelial cells 3/51 78/9376 7.07088989441931 ACTB/ACTG1/ACTR3 3.98154100447098 Organismal Systems Immune system hsa04612 Antigen processing and presentation 3/51 82/9376 6.72596843615495 HLA-DQB1/HSPA1B/HLA-DQA1 3.85124234254642 Human Diseases Infectious disease: bacterial hsa05131 Shigellosis 5/51 253/9376 3.63326358211269 ACTB/PFN1/ACTG1/ACTR3/UBE2N 3.14001745356603 Metabolism Carbohydrate metabolism hsa00030 Pentose phosphate pathway 2/51 31/9376 11.8608475648324 ALDOA/FBP1 4.47920787835977 Human Diseases Immune disease hsa05310 Asthma 2/51 32/9376 11.4901960784314 HLA-DQB1/HLA-DQA1 4.39580568360588 Metabolism Carbohydrate metabolism hsa00051 Fructose and mannose metabolism 2/51 35/9376 10.5053221288515 ALDOA/FBP1 4.16629945169423 Human Diseases Infectious disease: viral hsa05168 Herpes simplex virus 1 infection 4/51 180/9376 4.08540305010893 HLA-DQB1/ALYREF/CFP/HLA-DQA1 3.09097136522046 Human Diseases Infectious disease: parasitic hsa05146 Amoebiasis 3/51 103/9376 5.35465448315248 CD1D/CD1C/CD1E 3.28630971291425 Human Diseases Immune disease hsa05330 Allograft rejection 2/51 39/9376 9.42785319255908 HLA-DQB1/HLA-DQA1 3.90024502905812 Human Diseases Infectious disease: parasitic hsa05145 Toxoplasmosis 3/51 112/9376 4.92436974789916 HLA-DQB1/HSPA1B/HLA-DQA1 3.08976865700585 Human Diseases Infectious disease: bacterial hsa05130 Pathogenic Escherichia coli infection 4/51 200/9376 3.67686274509804 ACTB/ACTG1/GAPDH/ACTR3 2.8298323361094 Human Diseases Endocrine and metabolic disease hsa04940 Type I diabetes mellitus 2/51 44/9376 8.35650623885918 HLA-DQB1/HLA-DQA1 3.61706977684887 Human Diseases Immune disease hsa05332 Graft-versus-host disease 2/51 45/9376 8.17080610021786 HLA-DQB1/HLA-DQA1 3.56579562218378 Human Diseases Infectious disease: viral hsa05169 Epstein-Barr virus infection 4/51 205/9376 3.58718316594931 HLA-DQB1/CCND3/VIM/HLA-DQA1 2.76975953778454 Genetic Information Processing Chromosome hsa03082 ATP-dependent chromatin remodeling 3/51 117/9376 4.71392659627954 ACTB/ACTG1/RUVBL1 2.98944460817607 NA NA hsa04382 Cornified envelope formation 4/51 217/9376 3.38881358995211 S100A6/S100A10/S100A4/S100A8 2.63290024251062 Organismal Systems Immune system hsa04672 Intestinal immune network for IgA production 2/51 50/9376 7.35372549019608 HLA-DQB1/HLA-DQA1 3.33128699993734 Human Diseases Infectious disease: bacterial hsa05110 Vibrio cholerae infection 2/51 51/9376 7.20953479430988 ACTB/ACTG1 3.28825916125721 Human Diseases Immune disease hsa05320 Autoimmune thyroid disease 2/51 54/9376 6.80900508351489 HLA-DQB1/HLA-DQA1 3.16585043220328 Cellular Processes Cell motility hsa04820 Cytoskeleton in muscle cells 4/51 233/9376 3.15610536059918 ACTB/ENO1/ACTG1/VIM 2.46461953230209 Human Diseases Infectious disease: bacterial hsa05135 Yersinia infection 3/51 138/9376 3.99658994032396 ACTB/ACTG1/ACTR3 2.62255247914117 Human Diseases Cardiovascular disease hsa05418 Fluid shear stress and atherosclerosis 3/51 142/9376 3.88400994200497 ACTB/ACTG1/MGST1 2.56089809033419 Human Diseases Immune disease hsa05321 Inflammatory bowel disease 2/51 66/9376 5.57100415923945 HLA-DQB1/HLA-DQA1 2.75584666461437 NA NA hsa04518 Integrin signaling 3/51 154/9376 3.58135981665393 ACTB/ACTG1/CCND3 2.38859573611669 Environmental Information Processing Signal transduction hsa04390 Hippo signaling pathway 3/51 157/9376 3.51292618958411 ACTB/ACTG1/CCND3 2.34819390943825 Cellular Processes Cell growth and death hsa04110 Cell cycle 3/51 158/9376 3.49069247952346 CDT1/CCND3/MCM7 2.33494474128394 Organismal Systems Digestive system hsa04971 Gastric acid secretion 2/51 76/9376 4.83797729618163 ACTB/ACTG1 2.48435714553603 Human Diseases Cancer: specific types hsa05225 Hepatocellular carcinoma 3/51 170/9376 3.24429065743945 ACTB/ACTG1/MGST1 2.1838076499193 Human Diseases Infectious disease: parasitic hsa05140 Leishmaniasis 2/51 78/9376 4.71392659627954 HLA-DQB1/HLA-DQA1 2.43574686542668 Environmental Information Processing Signal transduction hsa04310 Wnt signaling pathway 3/51 178/9376 3.09847984137475 CCND3/DKK1/RUVBL1 2.09032784677413 Human Diseases Cardiovascular disease hsa05412 Arrhythmogenic right ventricular cardiomyopathy 2/51 86/9376 4.27542179662563 ACTB/ACTG1 2.25660169173524 Cellular Processes Cellular community - eukaryotes hsa04520 Adherens junction 2/51 93/9376 3.95361585494413 ACTB/ACTG1 2.11688670662791 Organismal Systems Immune system hsa04658 Th1 and Th2 cell differentiation 2/51 93/9376 3.95361585494413 HLA-DQB1/HLA-DQA1 2.11688670662791 Human Diseases Immune disease hsa05323 Rheumatoid arthritis 2/51 95/9376 3.8703818369453 HLA-DQB1/HLA-DQA1 2.0794591610609 Cellular Processes Cellular community - eukaryotes hsa04510 Focal adhesion 3/51 203/9376 2.71689365401333 ACTB/ACTG1/CCND3 1.82886657892909 Human Diseases Cancer: overview hsa05205 Proteoglycans in cancer 3/51 204/9376 2.70357554786621 ACTB/ACTG1/RPS6 1.81924321778397 Organismal Systems Immune system hsa04666 Fc gamma R-mediated phagocytosis 2/51 98/9376 3.75190076030412 CFL1/ACTR3 2.02518605366248 Human Diseases Infectious disease: bacterial hsa05150 Staphylococcus aureus infection 2/51 99/9376 3.7140027728263 HLA-DQB1/HLA-DQA1 2.00756868179422 Human Diseases Cardiovascular disease hsa05410 Hypertrophic cardiomyopathy 2/51 99/9376 3.7140027728263 ACTB/ACTG1 2.00756868179422 Environmental Information Processing Signal transduction hsa04015 Rap1 signaling pathway 3/51 212/9376 2.6015538290788 ACTB/PFN1/ACTG1 1.74426809215793 Human Diseases Cardiovascular disease hsa05414 Dilated cardiomyopathy 2/51 105/9376 3.50177404295051 ACTB/ACTG1 1.90645143802245 Human Diseases Cancer: overview hsa05207 Chemical carcinogenesis - receptor activation 3/51 217/9376 2.54161019246408 VDR/CCND3/MGST1 1.69913042468789 Organismal Systems Endocrine system hsa04922 Glucagon signaling pathway 2/51 107/9376 3.43632032252153 FBP1/PKM 1.87437352634493 Genetic Information Processing Translation hsa03013 Nucleocytoplasmic transport 2/51 108/9376 3.40450254175744 ALYREF/RAN 1.85861916782006 Organismal Systems Immune system hsa04659 Th17 cell differentiation 2/51 109/9376 3.37326857348444 HLA-DQB1/HLA-DQA1 1.84304891587673 Organismal Systems Immune system hsa04670 Leukocyte transendothelial migration 2/51 116/9376 3.16970926301555 ACTB/ACTG1 1.73888695873659 Organismal Systems Environmental adaptation hsa04714 Thermogenesis 3/51 235/9376 2.34693366708385 ACTB/ACTG1/RPS6 1.54642759598262 Human Diseases Neurodegenerative disease hsa05014 Amyotrophic lateral sclerosis 4/51 368/9376 1.99829497016198 ACTB/PFN1/ACTG1/ALYREF 1.44482387506049 Organismal Systems Endocrine system hsa04919 Thyroid hormone signaling pathway 2/51 122/9376 3.01382192221151 ACTB/ACTG1 1.65570338998253 Organismal Systems Immune system hsa04611 Platelet activation 2/51 126/9376 2.91814503579209 ACTB/ACTG1 1.60303186149163 Metabolism Nucleotide metabolism hsa00230 Purine metabolism 2/51 128/9376 2.87254901960784 PNP/PAICS 1.57746806440101 Human Diseases Infectious disease: viral hsa05162 Measles 2/51 136/9376 2.70357554786621 CCND3/HSPA1B 1.47992999477035 Cellular Processes Cell growth and death hsa04210 Apoptosis 2/51 137/9376 2.68384141977959 ACTB/ACTG1 1.46823405899188 Organismal Systems Endocrine system hsa04910 Insulin signaling pathway 2/51 138/9376 2.6643932935493 FBP1/RPS6 1.45664199813465 NA NA hsa04519 Cadherin signaling 4/51 404/9376 1.8202290817317 ACTB/ACTG1/ACTR3/VIM 1.24631413195244 Genetic Information Processing Replication and repair hsa03030 DNA replication 1/51 36/9376 5.10675381263617 MCM7 1.82567213606213 Human Diseases Immune disease hsa05322 Systemic lupus erythematosus 2/51 143/9376 2.57123268887975 HLA-DQB1/HLA-DQA1 1.40017852620789 Metabolism Metabolism of cofactors and vitamins hsa00760 Nicotinate and nicotinamide metabolism 1/51 38/9376 4.83797729618163 PNP 1.75312777682701 Organismal Systems Endocrine system hsa04921 Oxytocin signaling pathway 2/51 154/9376 2.38757321110262 ACTB/ACTG1 1.2839556245536 Environmental Information Processing Signaling molecules and interaction hsa04514 Cell adhesion molecule (CAM) interaction 2/51 160/9376 2.29803921568627 HLA-DQB1/HLA-DQA1 1.22468071094083 NA NA hsa04517 IgSF CAM signaling 3/51 299/9376 1.84457997245721 ACTB/ACTG1/ACTR3 1.09761873481513 Metabolism Carbohydrate metabolism hsa00620 Pyruvate metabolism 1/51 47/9376 3.91155611180643 PKM 1.47979941987924 Human Diseases Endocrine and metabolic disease hsa04930 Type II diabetes mellitus 1/51 47/9376 3.91155611180643 PKM 1.47979941987924 Organismal Systems Digestive system hsa04979 Cholesterol metabolism 1/51 52/9376 3.53544494720965 TSPO 1.35581686076094 Organismal Systems Excretory system hsa04961 Endocrine and other factor-regulated calcium reabsorption 1/51 53/9376 3.46873843877174 VDR 1.33285061850593 Human Diseases Infectious disease: bacterial hsa05134 Legionellosis 1/51 56/9376 3.28291316526611 HSPA1B 1.2671317003137 Metabolism Metabolism of other amino acids hsa00480 Glutathione metabolism 1/51 59/9376 3.11598537720173 MGST1 1.20572128079155 Organismal Systems Immune system hsa04062 Chemokine signaling pathway 2/51 193/9376 1.90511023062075 FGR/CCR2 0.939580818693962 Organismal Systems Digestive system hsa04978 Mineral absorption 1/51 61/9376 3.01382192221151 VDR 1.16691939485237 Cellular Processes Cell motility hsa04814 Motor proteins 2/51 194/9376 1.8952900747928 ACTB/ACTG1 0.931842033465289 Organismal Systems Immune system hsa04613 Neutrophil extracellular trap formation 2/51 195/9376 1.88557063851181 ACTB/ACTG1 0.924148636053861 Organismal Systems Aging hsa04213 Longevity regulating pathway - multiple species 1/51 62/9376 2.9652118912081 HSPA1B 1.14810978224723 Metabolism Lipid metabolism hsa00590 Arachidonic acid metabolism 1/51 63/9376 2.91814503579209 LTA4H 1.129674229076 Human Diseases Cancer: overview hsa05203 Viral carcinogenesis 2/51 205/9376 1.79359158297465 CCND3/PKM 0.849594990018053 Human Diseases Cancer: overview hsa05204 Chemical carcinogenesis - DNA adducts 1/51 70/9376 2.62633053221289 MGST1 1.01000289194276 Human Diseases Cancer: overview hsa05230 Central carbon metabolism in cancer 1/51 71/9376 2.58933996133665 PKM 0.994109204078823 Metabolism Xenobiotics biodegradation and metabolism hsa00982 Drug metabolism - cytochrome P450 1/51 73/9376 2.51839914047811 MGST1 0.963123932786538 Genetic Information Processing Information processing in viruses hsa03250 Viral life cycle - HIV-1 1/51 73/9376 2.51839914047811 RAN 0.963123932786538 Human Diseases Drug resistance: antineoplastic hsa01524 Platinum drug resistance 1/51 75/9376 2.45124183006536 MGST1 0.933150951771406 Cellular Processes Cell growth and death hsa04115 p53 signaling pathway 1/51 75/9376 2.45124183006536 CCND3 0.933150951771406 Organismal Systems Endocrine system hsa03320 PPAR signaling pathway 1/51 76/9376 2.41898864809082 FABP5 0.918524085805873 Genetic Information Processing Folding, sorting and degradation hsa03018 RNA degradation 1/51 78/9376 2.35696329813977 ENO1 0.889952726382375 Human Diseases Infectious disease: bacterial hsa05133 Pertussis 1/51 78/9376 2.35696329813977 CFL1 0.889952726382375 Metabolism Xenobiotics biodegradation and metabolism hsa00980 Metabolism of xenobiotics by cytochrome P450 1/51 79/9376 2.3271283196823 MGST1 0.875994446470339 Human Diseases Drug resistance: antineoplastic hsa01521 EGFR tyrosine kinase inhibitor resistance 1/51 80/9376 2.29803921568627 RPS6 0.862245735925945 Metabolism Xenobiotics biodegradation and metabolism hsa00983 Drug metabolism - other enzymes 1/51 82/9376 2.24198947871832 MGST1 0.835352573589998 Metabolism Global and overview maps hsa01232 Nucleotide metabolism 1/51 85/9376 2.16286043829296 PNP 0.796438295902365 Organismal Systems Immune system hsa04610 Complement and coagulation cascades 1/51 88/9376 2.0891265597148 SERPINA1 0.759110306130796 Genetic Information Processing Transcription hsa03040 Spliceosome 2/51 243/9376 1.51311224078109 ALYREF/HSPA1B 0.599314919501763 Cellular Processes Transport and catabolism hsa04144 Endocytosis 2/51 250/9376 1.47074509803922 ACTR3/HSPA1B 0.557907095002965 Organismal Systems Digestive system hsa04970 Salivary secretion 1/51 93/9376 1.97680792747206 LYZ 0.700088236976738 Organismal Systems Immune system hsa04657 IL-17 signaling pathway 1/51 94/9376 1.95577805590321 S100A8 0.688726043827893 Environmental Information Processing Signaling molecules and interaction hsa04061 Viral protein interaction with cytokine and cytokine receptor 1/51 100/9376 1.83843137254902 CCR2 0.623352142429872 Genetic Information Processing Translation hsa03015 mRNA surveillance pathway 1/51 103/9376 1.78488482771749 ALYREF 0.59232589929379 Organismal Systems Immune system hsa04625 C-type lectin receptor signaling pathway 1/51 105/9376 1.75088702147526 LSP1 0.572205809680396 Organismal Systems Endocrine system hsa04928 Parathyroid hormone synthesis, secretion and action 1/51 115/9376 1.59863597612958 VDR 0.477671243702481 Environmental Information Processing Signal transduction hsa04152 AMPK signaling pathway 1/51 122/9376 1.50691096110575 FBP1 0.416766838946919 Organismal Systems Endocrine system hsa04915 Estrogen signaling pathway 1/51 139/9376 1.3226124982367 HSPA1B 0.283380147870081 Environmental Information Processing Signal transduction hsa04371 Apelin signaling pathway 1/51 140/9376 1.31316526610644 RPS6 0.27608445175043 Genetic Information Processing Folding, sorting and degradation hsa04120 Ubiquitin mediated proteolysis 1/51 142/9376 1.29466998066832 UBE2N 0.261656445694396 Human Diseases Infectious disease: viral hsa05165 Human papillomavirus infection 2/51 333/9376 1.10416298651593 CCND3/PKM 0.143128322295288 Cellular Processes Cell growth and death hsa04218 Cellular senescence 1/51 157/9376 1.17097539652804 CCND3 0.159767281050691 Environmental Information Processing Signal transduction hsa04150 mTOR signaling pathway 1/51 158/9376 1.16356415984115 RPS6 0.153336181814262 Environmental Information Processing Signal transduction hsa04151 PI3K-Akt signaling pathway 2/51 362/9376 1.01570794063482 CCND3/RPS6 0.0225403712957771 Environmental Information Processing Signal transduction hsa04630 JAK-STAT signaling pathway 1/51 168/9376 1.09430438842204 CCND3 0.0912116253046077 Genetic Information Processing Folding, sorting and degradation hsa04141 Protein processing in endoplasmic reticulum 1/51 174/9376 1.05656975433852 HSPA1B 0.0557011431749582 Human Diseases Neurodegenerative disease hsa05010 Alzheimer disease 2/51 388/9376 0.947645037396402 GAPDH/DKK1 -0.0778912172126327 Genetic Information Processing Translation hsa03008 Ribosome biogenesis in eukaryotes 1/51 183/9376 1.00460730740384 RAN 0.00465468622817513 Organismal Systems Development and regeneration hsa04360 Axon guidance 1/51 184/9376 0.999147485080989 CFL1 -0.000863678676883757 Human Diseases Cardiovascular disease hsa05415 Diabetic cardiomyopathy 1/51 205/9376 0.896795791487327 GAPDH -0.11048728386519 Human Diseases Infectious disease: viral hsa05170 Human immunodeficiency virus 1 infection 1/51 214/9376 0.859080080630383 CFL1 -0.15421635531705 Human Diseases Cardiovascular disease hsa05417 Lipid and atherosclerosis 1/51 216/9376 0.851125635439361 HSPA1B -0.163698750899815 Human Diseases Cancer: overview hsa05208 Chemical carcinogenesis - reactive oxygen species 1/51 227/9376 0.809881661915868 MGST1 -0.214435374208097 Human Diseases Neurodegenerative disease hsa05020 Prion disease 1/51 275/9376 0.668520499108734 HSPA1B -0.412595770753978 Environmental Information Processing Signaling molecules and interaction hsa04060 Cytokine-cytokine receptor interaction 1/51 298/9376 0.616923279378866 CCR2 -0.496987092695565 Environmental Information Processing Signal transduction hsa04010 MAPK signaling pathway 1/51 300/9376 0.61281045751634 HSPA1B -0.504061246183122 Human Diseases Cancer: overview hsa05206 MicroRNAs in cancer 1/51 323/9376 0.56917379955078 VIM -0.582711264754674 Environmental Information Processing Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction 1/51 370/9376 0.496873343932167 TSPO -0.73022807119691 Human Diseases Neurodegenerative disease hsa05022 Pathways of neurodegeneration - multiple diseases 1/51 480/9376 0.383006535947712 DKK1 -1.02624274772804