category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	5/115	52/9376	7.83946488294314	CGA/CYP11A1/HSD3B1/SCARB1/CYP19A1	5.51097295435884
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	7/115	142/9376	4.01910593998775	FOS/DUSP1/CALM1/ACTG1/PIK3CB/SDC1/SQSTM1	4.03955202723714
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	5/115	98/9376	4.15971606033718	CYP11A1/CALM1/HSD3B1/SCARB1/PRKD3	3.50380176981767
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	6/115	139/9376	3.51929934313419	FOS/KRT19/CALM1/PIK3CB/KRT10/HSPA1B	3.33447386635639
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	4/115	66/9376	4.94123847167325	CYP11A1/HSD3B1/CYP19A1/STS	3.58043222270096
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	6/115	157/9376	3.11581279423982	GADD45G/CALM1/SERPINE1/PIK3CB/RAD9A/SQSTM1	2.97913904839905
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	7/115	204/9376	2.79761295822677	HSPG2/ACTG1/EZR/PIK3CB/TIMP3/SDC1/PDCD4	2.89257658964912
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/115	15/9376	10.8707246376812	ST3GAL1/HEXB	4.2632338918746
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	7/115	212/9376	2.69204265791632	FLT1/CALM1/ACTG1/PRKD3/PIK3CB/RAPGEF3/SIPA1L1	2.77678538129822
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/115	16/9376	10.1913043478261	ST3GAL1/HEXB	4.10019800688719
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	3/115	44/9376	5.55889328063241	MAN1C1/TUSC3/HEXB	3.37756733115335
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	6/115	168/9376	2.91180124223602	LEP/PIK3CB/CSF2RB/LIFR/IL11RA/FHL1	2.78625166678802
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	6/115	174/9376	2.81139430284858	MAN1C1/DERL3/PPP1R15A/TUSC3/UBXN1/HSPA1B	2.68752259014653
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	5/115	137/9376	2.97556331323389	FOS/GADD45G/ACTG1/PIK3CB/CSF2RB	2.59563946615209
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	8/115	298/9376	2.18873650423111	LEP/EBI3/INHBA/GDF15/CSF2RB/LIFR/INHA/IL11RA	2.32382948897463
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	5/115	142/9376	2.87078995713411	FOS/FOSB/JUNB/PIK3CB/SQSTM1	2.50310970005465
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	3/115	56/9376	4.36770186335404	MAN1C1/MGAT3/TUSC3	2.81660088115047
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	5/115	157/9376	2.59651066186652	LEP/FOS/PIK3CB/MLX/NDUFS2	2.24794332792604
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	5/115	158/9376	2.58007705008255	PIK3CB/SGK1/CASTOR2/FNIP2/ATP6V1C2	2.23199939757186
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	3/115	65/9376	3.76294314381271	CYP11A1/HSD3B1/SCARB1	2.49078406897374
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	3/115	69/9376	3.54480151228733	FOS/FOSB/CALM1	2.36417281328842
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	4/115	116/9376	2.81139430284858	ACTG1/EZR/PIK3CB/RAPGEF3	2.18747004739812
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	3/115	71/9376	3.44494794856093	CGA/FOS/PIK3CB	2.30433820117662
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	5/115	169/9376	2.41214304090558	UBC/PIK3CB/SQSTM1/ATG4B/ATG16L2	2.06427991577298
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	6/115	226/9376	2.1645248172374	CGA/FOS/CALM1/CRH/PIK3CB/RAPGEF3	1.97468595410258
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	3/115	76/9376	3.21830663615561	PLIN2/UBC/LPL	2.16367743855288
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	3/115	76/9376	3.21830663615561	CALM1/ACTG1/EZR	2.16367743855288
Human Diseases	Cancer: specific types	hsa05214	Glioma	3/115	76/9376	3.21830663615561	GADD45G/CALM1/PIK3CB	2.16367743855288
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	3/115	78/9376	3.13578595317726	PIP5KL1/IMPA2/PIK3CB	2.1106483013603
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	2/115	38/9376	4.29107551487414	HEXB/GALE	2.26520925433231
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	2/115	38/9376	4.29107551487414	PIK3CB/SGK1	2.26520925433231
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	3/115	87/9376	2.81139430284858	FOS/GADD45G/PIK3CB	1.89144518010702
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/115	42/9376	3.8824016563147	KYNU/KMO	2.08617560145968
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	4/115	144/9376	2.26473429951691	INHBA/PIK3CB/LIFR/DLX5	1.70426945818014
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	3/115	91/9376	2.68781653129479	FOS/PIK3CB/PIK3AP1	1.80285415299847
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	2/115	44/9376	3.70592885375494	TAF7/GTF2I	2.0047534202424
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	3/115	94/9376	2.60203515263645	FOS/FOSB/ANAPC5	1.73948545786665
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	3/115	95/9376	2.57464530892449	FLT1/FOS/ATP6V1C2	1.7189085677059
NA	NA	hsa03272	Virion - Hepatitis viruses	2/115	48/9376	3.39710144927536	HSPG2/SCARB1	1.85531809690012
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	3/115	98/9376	2.49582963620231	CALM1/IMPA2/PIK3CB	1.65872199482129
NA	NA	hsa04518	Integrin signaling	4/115	154/9376	2.11767363071711	FLT1/ACTG1/FLNB/PIK3CB	1.5583622616393
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	4/115	155/9376	2.10401122019635	CYP11A1/CRH/HSD3B1/SCARB1	1.54438630404739
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	2/115	51/9376	3.19727195225916	ACTG1/ATP6V1C2	1.7532752257459
NA	NA	hsa04081	Hormone signaling	5/115	219/9376	1.86142545165773	CGA/LEP/CRH/PIK3CB/RAPGEF3	1.43737062756392
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	3/115	103/9376	2.37467285774588	FOS/SERPINE1/PIK3CB	1.56319607730374
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	3/115	103/9376	2.37467285774588	PIK3CB/SERPINB9/HSPB1	1.56319607730374
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	2/115	52/9376	3.13578595317726	SCARB1/LPL	1.72093267904819
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/115	12/9376	6.79420289855072	NECTIN4	2.23799563855338
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	2/115	55/9376	2.96474308300395	ACER2/HEXB	1.62840143163298
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	5/115	227/9376	1.79582455468301	FOS/SLC26A6/PRKD3/PIK3CB/NDUFS2	1.35253672433223
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	3/115	110/9376	2.22355731225296	FLT1/SERPINE1/PIK3CB	1.43840150149365
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	3/115	110/9376	2.22355731225296	SPDYE2/ANAPC5/PIK3CB	1.43840150149365
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	4/115	170/9376	1.9183631713555	GADD45G/ACTG1/PIK3CB/SMARCB1	1.34650834965346
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	5/115	233/9376	1.74958014554954	HSPG2/ACTG1/SDC1/FMNL1/FHL1	1.29109230168728
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/115	14/9376	5.82360248447205	ST3GAL1	2.01259702274174
NA	NA	hsa04517	IgSF CAM signaling	6/115	299/9376	1.63606223644031	ACTG1/EZR/PIK3CB/GLDN/LRFN5/NECTIN4	1.2455743452872
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	6/115	300/9376	1.63060869565217	FLT1/FOS/GADD45G/DUSP1/HSPB1/HSPA1B	1.23702636261517
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2/115	59/9376	2.76374355195284	CGA/PIK3CB	1.51435959427991
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	2/115	59/9376	2.76374355195284	GADD45G/PIK3CB	1.51435959427991
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	3/115	115/9376	2.1268809073724	FOS/GCM1/SGK1	1.35488868251924
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	2/115	60/9376	2.71768115942029	PIK3CB/HSPB1	1.48733587576913
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	2/115	62/9376	2.63001402524544	PIK3CB/HSPA1B	1.43491007679521
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	3/115	119/9376	2.05538911216661	FOS/JUNB/PIK3CB	1.29109017020342
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	5/115	248/9376	1.6437587657784	FOS/ACTG1/SNX9/PIK3CB/RHOB	1.14489799989116
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	3/115	122/9376	2.00484675694939	FOS/JUNB/PIK3CB	1.24486030634981
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/115	17/9376	4.79590792838875	CDO1	1.74554489475529
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	2/115	65/9376	2.50862876254181	CGA/PIK3CB	1.3600238195815
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	5/115	250/9376	1.63060869565217	PIP5KL1/DAB2/RNF103-CHMP3/IQSEC1/HSPA1B	1.12614767220688
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	2/115	67/9376	2.43374432186892	CALM1/RAPGEF3	1.31239090925492
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/115	18/9376	4.52946859903382	HEXB	1.67016612469512
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/115	19/9376	4.29107551487414	HEXB	1.60011777439542
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	4/115	196/9376	1.66388642413487	FOS/CALM1/UBC/PIK3CB	1.04666113760809
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	3/115	133/9376	1.83903236351749	GADD45G/PIK3CB/SGK1	1.08593460591816
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	2/115	73/9376	2.23371054198928	RANBP2/SMARCB1	1.17914933832867
Human Diseases	Cancer: specific types	hsa05218	Melanoma	2/115	73/9376	2.23371054198928	GADD45G/PIK3CB	1.17914933832867
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	2/115	73/9376	2.23371054198928	GADD45G/PIK3CB	1.17914933832867
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	4/115	201/9376	1.62249621457928	FLT1/GADD45G/AFF1/ETV5	0.994116594340714
Human Diseases	Infectious disease: viral	hsa05162	Measles	3/115	136/9376	1.79846547314578	FOS/PIK3CB/HSPA1B	1.04518995253819
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	2/115	75/9376	2.17414492753623	GADD45G/SERPINE1	1.13760929540012
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	4/115	203/9376	1.60651103019919	FLT1/ACTG1/FLNB/PIK3CB	0.973501537967354
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	3/115	138/9376	1.77240075614367	ATP12A/NDUFS2/ATP6V1C2	1.01858873959812
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	3/115	138/9376	1.77240075614367	CALM1/SPDYE2/ANAPC5	1.01858873959812
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	3/115	138/9376	1.77240075614367	FOS/ACTG1/PIK3CB	1.01858873959812
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	2/115	77/9376	2.11767363071711	GADD45G/PIK3CB	1.09735680141456
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	2/115	77/9376	2.11767363071711	GADD45G/PIK3CB	1.09735680141456
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	2/115	78/9376	2.09052396878484	ACTG1/PIK3CB	1.0776887819139
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	2/115	78/9376	2.09052396878484	FOS/CALM1	1.0776887819139
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	3/115	142/9376	1.72247397428047	RHOBTB1/ANAPC5/UBC	0.966667372872171
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/115	24/9376	3.39710144927536	EXT1	1.31022355405774
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	4/115	214/9376	1.52393336042259	FOS/CALM1/PIK3CB/AP1G2	0.863959553622158
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	3/115	148/9376	1.65264394829612	FOS/GADD45G/PIK3CB	0.891782604129493
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	4/115	216/9376	1.50982286634461	FOS/CALM1/PIK3CB/HSPA1B	0.844703055949286
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/115	26/9376	3.13578595317726	SCARB1	1.21519006635872
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/115	27/9376	3.01964573268921	TECR	1.17106260946056
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/115	28/9376	2.91180124223602	TECR	1.12893261372489
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/115	28/9376	2.91180124223602	ATP6V1C2	1.12893261372489
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	3/115	154/9376	1.58825522303783	RDH13/KYNU/KMO	0.82019895128616
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	3/115	154/9376	1.58825522303783	FOS/CALM1/ACTG1	0.82019895128616
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	2/115	88/9376	1.85296442687747	SERPINE1/PROCR	0.895811777940706
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	3/115	155/9376	1.57800841514727	ACTG1/SCARB1/ATP6V1C2	0.808568122902602
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	2/115	89/9376	1.83214460185638	HSPG2/SDC1	0.878944994196935
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/115	29/9376	2.81139430284858	LIMD1	1.08863299072842
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/115	29/9376	2.81139430284858	CALM1	1.08863299072842
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	2/115	90/9376	1.81178743961353	FOS/PIK3CB	0.862292996385301
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	3/115	157/9376	1.55790639711991	ACTG1/SERPINE1/LIMD1	0.785551886980018
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	2/115	93/9376	1.75334268349696	ACTG1/NECTIN4	0.813571057021021
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	2/115	93/9376	1.75334268349696	FOS/MAML2	0.813571057021021
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	2/115	93/9376	1.75334268349696	CGA/CALM1	0.813571057021021
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	2/115	93/9376	1.75334268349696	GADD45G/PIK3CB	0.813571057021021
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	4/115	232/9376	1.40569715142429	ACTG1/EZR/PIK3CB/ARHGEF4	0.697241869001852
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	3/115	163/9376	1.50056014937317	FOS/HSPG2/PIK3CB	0.718381524411218
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/115	32/9376	2.54782608695652	GALE	0.977319023767324
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/115	32/9376	2.54782608695652	ATG4B	0.977319023767324
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	2/115	97/9376	1.68103989242492	FOS/CALM1	0.751300102052474
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	2/115	99/9376	1.64707949055775	FOS/PIK3CB	0.721235458737743
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	2/115	99/9376	1.64707949055775	CALM1/PIK3CB	0.721235458737743
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	2/115	99/9376	1.64707949055775	KRT19/KRT10	0.721235458737743
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	2/115	99/9376	1.64707949055775	FOS/PIK3CB	0.721235458737743
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/115	35/9376	2.32944099378882	ENOSF1	0.878035385543954
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	2/115	101/9376	1.61446405510116	SERPINE1/PIK3CB	0.691840252823644
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	3/115	173/9376	1.41382256848454	ACTG1/PIK3CB/TRIM25	0.612178578733661
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/115	36/9376	2.26473429951691	ST3GAL1	0.847193715102118
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/115	37/9376	2.20352526439483	GALE	0.817356464874228
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	1/115	37/9376	2.20352526439483	GADD45G	0.817356464874228
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	2/115	105/9376	1.55296066252588	GADD45G/TRIM25	0.634937842713028
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	2/115	105/9376	1.55296066252588	UBC/SQSTM1	0.634937842713028
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	2/115	105/9376	1.55296066252588	CALM1/PIK3CB	0.634937842713028
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	2/115	106/9376	1.5383100902379	PIK3CB/ETV5	0.621085231196756
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/115	38/9376	2.14553775743707	AICDA	0.78846040378164
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	4/115	253/9376	1.28901873174085	ACTG1/UBC/PIK3CB/SQSTM1	0.519305629284476
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	2/115	109/9376	1.49597128041484	FOS/PIK3CB	0.580371146123157
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	2/115	109/9376	1.49597128041484	FOS/EBI3	0.580371146123157
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	2/115	109/9376	1.49597128041484	PIK3CB/MLX	0.580371146123157
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	2/115	110/9376	1.48237154150198	INHBA/GREM2	0.5670710661658
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	1/115	42/9376	1.94120082815735	SAT1	0.681206312615694
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/115	43/9376	1.89605662285136	SCARB1	0.656242971796147
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	2/115	115/9376	1.41792060491493	FOS/PIK3CB	0.502480691691863
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	2/115	115/9376	1.41792060491493	DUSP1/RAPGEF3	0.502480691691863
Human Diseases	Substance dependence	hsa05034	Alcoholism	3/115	191/9376	1.28058274527658	FOSB/CALM1/CRH	0.436559737571212
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	4/115	268/9376	1.21687216093446	DUSP1/CALM1/UBC/NDUFS2	0.401388854537329
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	1/115	44/9376	1.85296442687747	AQP3	0.631939509331449
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	2/115	117/9376	1.39368264585656	ACTG1/SMARCB1	0.477488345625689
Cellular Processes	Cell motility	hsa04814	Motor proteins	3/115	194/9376	1.26077991931869	ACTG1/MYO7B/KIF2A	0.408989335345752
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	2/115	120/9376	1.35884057971014	CALM1/PIK3CB	0.440845199451032
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/115	47/9376	1.73469010175763	PIK3CB	0.562653710820883
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	2/115	122/9376	1.33656450463293	LEP/PIK3CB	0.416954913220584
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	2/115	122/9376	1.33656450463293	FOS/PIK3CB	0.416954913220584
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	2/115	122/9376	1.33656450463293	ACTG1/PIK3CB	0.416954913220584
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	3/115	200/9376	1.22295652173913	FOS/ACTG1/EZR	0.355151858900008
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/115	48/9376	1.69855072463768	PIK3CB	0.540667063304631
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/115	49/9376	1.66388642413487	FOSB	0.519190163420428
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	2/115	125/9376	1.30448695652174	ACER2/PIK3CB	0.381887088773988
Organismal Systems	Immune system	hsa04611	Platelet activation	2/115	126/9376	1.29413388543823	ACTG1/PIK3CB	0.370394971777178
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/115	50/9376	1.63060869565217	SAT1	0.498199018907261
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	1/115	50/9376	1.63060869565217	AICDA	0.498199018907261
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	1/115	50/9376	1.63060869565217	SDC1	0.498199018907261
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	2/115	130/9376	1.2543143812709	FOS/PIK3CB	0.32536532540013
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	5/115	370/9376	1.10176263219741	CGA/LEP/CRH/P2RY14/P2RY6	0.222550635585784
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	1/115	54/9376	1.50982286634461	CDO1	0.418665579795648
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	1/115	54/9376	1.50982286634461	CGA	0.418665579795648
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	2/115	133/9376	1.22602157567833	FOS/CALM1	0.292532995609684
NA	NA	hsa04382	Cornified envelope formation	3/115	217/9376	1.12714886796233	KRT19/S100A6/KRT10	0.211165979669358
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	3/115	217/9376	1.12714886796233	FOS/PIK3CB/PAQR7	0.211165979669358
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	1/115	56/9376	1.45590062111801	HSPA1B	0.381295655987541
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/115	57/9376	1.43035850495805	TECR	0.363152282686147
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	2/115	138/9376	1.18160050409578	CALM1/PIK3CB	0.239482195098857
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	2/115	140/9376	1.16472049689441	CALM1/SERPINE1	0.218814106020435
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	1/115	59/9376	1.38187177597642	PRDX6	0.327877137860721
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	3/115	224/9376	1.09192546583851	FOS/ANAPC5/PIK3CB	0.155169892437105
Organismal Systems	Nervous system	hsa04730	Long-term depression	1/115	60/9376	1.35884057971014	CRH	0.310719172156967
Organismal Systems	Digestive system	hsa04978	Mineral absorption	1/115	61/9376	1.33656450463293	SLC26A6	0.293864696998185
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	1/115	62/9376	1.31500701262272	MAML2	0.277302360392535
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	1/115	63/9376	1.29413388543823	GADD45G	0.26102142087598
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	2/115	149/9376	1.09436825211555	PIK3CB/RAPGEF3	0.129388119604569
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	2/115	150/9376	1.08707246376812	GADD45G/PIK3CB	0.119791320944612
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/115	65/9376	1.2543143812709	LPL	0.229263570189274
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	3/115	235/9376	1.04081406105458	ACTG1/SMARCB1/NDUFS2	0.0706077711924641
NA	NA	hsa04519	Cadherin signaling	5/115	404/9376	1.00904003443823	KRT19/ACTG1/LIMD1/KRT10/FMN1	0.0206976839618667
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	3/115	238/9376	1.0276945560833	FLT1/CALM1/PIK3CB	0.0482239661918833
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	4/115	323/9376	1.00966482702921	EZR/PIK3CB/TIMP3/PDCD4	0.019697209456852
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	2/115	154/9376	1.05883681535855	CALM1/RAPGEF3	0.0820356409330177
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/115	68/9376	1.19897698209719	RDH13	0.183499432266421
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	1/115	68/9376	1.19897698209719	PIK3CB	0.183499432266421
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	2/115	156/9376	1.04526198439242	SCARB1/PIK3CB	0.063523737941672
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	1/115	69/9376	1.18160050409578	PIK3CB	0.168710593965662
Organismal Systems	Endocrine system	hsa04924	Renin secretion	1/115	69/9376	1.18160050409578	CALM1	0.168710593965662
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	2/115	157/9376	1.03860426474661	SGK1/P2RY6	0.054356166507006
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	1/115	70/9376	1.16472049689441	LEP	0.154141917020838
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	1/115	70/9376	1.16472049689441	PIK3CB	0.154141917020838
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	1/115	70/9376	1.16472049689441	ACTG1	0.154141917020838
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	2/115	158/9376	1.03203082003302	GADD45G/ANAPC5	0.045246382772094
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	1/115	71/9376	1.14831598285364	ATP6V1C2	0.139786282704247
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	1/115	71/9376	1.14831598285364	PIK3CB	0.139786282704247
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	1/115	72/9376	1.13236714975845	TRIM25	0.125636905507938
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	3/115	250/9376	0.978365217391304	AP1G2/HEXB/ATP6V1C2	-0.0386356233928671
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	1/115	75/9376	1.08707246376812	PIK3CB	0.0843630473827873
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	1/115	75/9376	1.08707246376812	CGA	0.0843630473827873
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	2/115	166/9376	0.982294394971189	CALM1/GTF2I	-0.0256472388927242
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	2/115	168/9376	0.970600414078675	SQSTM1/RNF103-CHMP3	-0.0428468417461446
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	1/115	78/9376	1.04526198439242	FOS	0.0447292624674956
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	2/115	170/9376	0.959181585677749	ACTG1/EZR	-0.0598481487703829
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	1/115	79/9376	1.03203082003302	ATP6V1C2	0.0318578016358977
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	1/115	80/9376	1.01913043478261	PIK3CB	0.0191481752099759
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	1/115	82/9376	0.994273594909862	HSPA1B	-0.00580354392057722
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	2/115	180/9376	0.905893719806763	SRSF5/PIK3CB	-0.142056462164888
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	4/115	362/9376	0.900888782128273	FLT1/PIK3CB/PIK3AP1/SGK1	-0.214300871613055
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	1/115	86/9376	0.948028311425682	PIK3CB	-0.05395277813803
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	1/115	86/9376	0.948028311425682	ACTG1	-0.05395277813803
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	3/115	275/9376	0.889422924901186	PIK3CB/NDUFS2/HSPA1B	-0.207392240850855
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	4/115	368/9376	0.886200378071834	ACTG1/RANBP2/SQSTM1/NDUFS2	-0.248173928847581
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	1/115	90/9376	0.905893719806763	PIK3CB	-0.0999611257414048
Organismal Systems	Digestive system	hsa04976	Bile secretion	1/115	90/9376	0.905893719806763	SCARB1	-0.0999611257414048
Organismal Systems	Digestive system	hsa04970	Salivary secretion	1/115	93/9376	0.876671341748481	CALM1	-0.133188559539621
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	2/115	195/9376	0.836209587513935	ACTG1/PIK3CB	-0.257552876614945
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	1/115	98/9376	0.831943212067436	PIK3CB	-0.186357780175082
NA	NA	hsa04082	Neuroactive ligand signaling	2/115	199/9376	0.819401354599082	P2RY14/P2RY6	-0.286943424564521
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	4/115	388/9376	0.840519946212461	CALM1/PIK3CB/NDUFS2/LPL	-0.357516689855971
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	1/115	99/9376	0.823539745278876	ACTG1	-0.19668277950375
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	1/115	100/9376	0.815304347826087	IL11RA	-0.206910208504025
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	1/115	101/9376	0.807232027550581	CALM1	-0.217042220270722
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	2/115	205/9376	0.79541887592789	GADD45G/PIK3CB	-0.330019620533427
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	2/115	205/9376	0.79541887592789	PIK3CB/NDUFS2	-0.330019620533427
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	1/115	105/9376	0.77648033126294	ACTG1	-0.256656767632539
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	1/115	107/9376	0.761966680211296	CALM1	-0.275942641728005
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	1/115	108/9376	0.754911433172303	RANBP2	-0.285461493552435
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	1/115	112/9376	0.727950310559006	HSPA1B	-0.32274802168098
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	2/115	227/9376	0.718329821873204	CALM1/PIK3CB	-0.478710109940547
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	3/115	333/9376	0.734508421464943	PIK3CB/MAML2/ATP6V1C2	-0.549695545074869
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	2/115	238/9376	0.685129704055535	FOS/PIK3CB	-0.548277230397957
Genetic Information Processing	Transcription	hsa03040	Spliceosome	2/115	243/9376	0.671032385042047	SRSF5/HSPA1B	-0.578968812952456
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	1/115	133/9376	0.613010787839163	PIK3CB	-0.500868614698791
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	1/115	134/9376	0.608436080467229	CALM1	-0.508718698036593
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	2/115	254/9376	0.641971927422116	FLT1/CALM1	-0.644606263516021
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	1/115	144/9376	0.566183574879227	PIK3CB	-0.584581349673708
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	1/115	149/9376	0.547184126057776	NDUFS2	-0.620854928887973
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	4/115	480/9376	0.679420289855072	CALM1/UBC/SQSTM1/NDUFS2	-0.803461145754916
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	1/115	160/9376	0.509565217391304	SDC1	-0.697229314140585
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	1/115	181/9376	0.450444391064136	CALM1	-0.831918307590474
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	2/115	308/9376	0.529418407679277	TGM2/NDUFS2	-0.935750685055332
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	1/115	184/9376	0.443100189035917	PIK3CB	-0.850132443482725
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	1/115	193/9376	0.422437485920252	PIK3CB	-0.903422654364432
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	1/115	205/9376	0.397709437963945	PIK3CB	-0.971583784357067
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/115	449/9376	0.181582260094897	CALM1	-1.98039150120758