category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	10/265	77/9376	4.59495221759373	GADD45G/PIK3CB/SOS2/BRAF/HDAC2/GADD45B/CRK/NFKBIA/PIK3R1/GAB2	5.40189219663879
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	17/265	204/9376	2.94842767295597	HSPG2/PIK3CB/EZR/SOS2/TIMP3/BRAF/ACTG1/CD63/FGFR1/DDX5/HPSE2/CTTN/HPSE/RAC1/SDC1/PIK3R1/ERBB3	4.79836081277225
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	13/265	142/9376	3.23911772521924	DUSP1/FOS/PIK3CB/CALM1/ACTG1/MGST3/MAP3K5/BMPR2/HMOX1/RAC1/TRPV4/SDC1/PIK3R1	4.58513066850677
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	20/265	300/9376	2.35874213836478	FLT1/GADD45G/DUSP1/FOS/HSPB1/HSPA1B/SOS2/MAP3K13/BRAF/MAP3K5/GADD45B/MAP3K4/FGFR1/HSPA8/CRK/RAC1/HSPA1A/MAP3K8/ERBB3/MAP4K2	4.0792092136153
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	8/265	62/9376	4.56530736457699	PIK3CB/HSPA1B/HDAC2/HSPA8/CRYAB/FOXO1/HSPA1A/PIK3R1	4.80341661610257
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	12/265	139/9376	3.05448622234288	FOS/KRT19/PIK3CB/HSPA1B/SOS2/CALM1/KRT23/KRT10/KRT15/HSPA8/HSPA1A/PIK3R1	4.16169945237282
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	16/265	227/9376	2.49382428725792	FOS/PIK3CB/SLC26A6/PRKD3/SOS2/BRAF/MGST3/MAP3K5/HMOX1/NFKBIA/RAC1/UQCRC1/SLC25A6/PIK3R1/SLC25A4/NDUFA6	3.88553819778391
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	8/265	70/9376	4.04355795148248	PIK3CB/SOS2/EPAS1/BRAF/EGLN3/CRK/RAC1/PIK3R1	4.35887709082484
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	11/265	125/9376	3.11353962264151	PIK3CB/ACER2/MAP3K5/CERS4/DEGS1/PPP2R2B/RAC1/PIK3R1/SPTLC3/GAB2/ADORA1	4.05692157023018
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	11/265	133/9376	2.926259043836	GADD45G/PIK3CB/SOS2/SGK1/BRAF/BCL6/GADD45B/PLK3/FOXO1/PIK3R1/CSNK1E	3.8155714152883
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	8/265	78/9376	3.62883405902274	PIK3CB/ACTG1/DNM2/CRK/CTTN/RAC1/PIK3R1/ELMO3	3.97595312048466
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	12/265	157/9376	2.70429034971758	GADD45G/PIK3CB/SERPINE1/CALM1/GADD45B/FOXO1/RAD9A/SLC25A6/TRPV4/PIK3R1/SLC25A4/HLA-C	3.67262896828307
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	15/265	226/9376	2.34830522624812	CGA/FOS/PIK3CB/CRH/CALM1/BRAF/RAPGEF3/LHB/PDE4D/NFKBIA/RAC1/PIK3R1/PDE10A/CHRM2/ADORA1	3.49910876634789
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	5/265	32/9376	5.52830188679245	GALE/UGP2/AKR1B1/PGM1/B4GALT1	4.37592125498907
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	10/265	119/9376	2.97320437609006	FOS/JUNB/PIK3CB/MMP14/MAP3K5/CXCL1/TNFRSF1B/NFKBIA/MAP3K8/PIK3R1	3.69433241562514
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	10/265	120/9376	2.94842767295597	PIK3CB/SOS2/CALM1/BRAF/MAP3K5/CRK/NFKBIA/RAC1/PIK3R1/MAGED1	3.66343753659144
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	11/265	142/9376	2.74079192133936	FOS/JUNB/FOSB/PIK3CB/BLNK/MITF/NFKBIA/RAC1/PIK3R1/SIRPA/GAB2	3.56468904520882
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	8/265	87/9376	3.25343743222728	GADD45G/FOS/PIK3CB/SOS2/BRAF/GADD45B/RAC1/PIK3R1	3.60119137150098
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	12/265	170/9376	2.49749167591565	GADD45G/PIK3CB/SOS2/BRAF/ACTG1/MGST3/GADD45B/SMARCA2/HMOX1/SMARCB1/PIK3R1/SMARCC2	3.36030690383211
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	6/265	52/9376	4.08243831640058	CGA/HSD3B1/LDLR/SCARB1/CYP11A1/LHB	3.80119794495567
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	12/265	174/9376	2.44007807417046	MAN1C1/HSPA1B/DERL3/PPP1R15A/DNAJB1/MAP3K5/CALR/HERPUD1/HSPA8/UGGT2/CRYAB/HSPA1A	3.26998002424568
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	8/265	91/9376	3.11042919344806	FOS/PIK3CB/SOS2/BLNK/PIK3AP1/NFKBIA/RAC1/PIK3R1	3.45005548644242
Human Diseases	Cancer: specific types	hsa05218	Melanoma	7/265	73/9376	3.39271129490824	GADD45G/PIK3CB/BRAF/GADD45B/FGFR1/MITF/PIK3R1	3.4999816800909
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	9/265	115/9376	2.76895816242822	FOS/GCM1/SGK1/MMP14/BRAF/WNK2/FGFR1/PDE4D/TRPV5	3.25509067899253
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	10/265	137/9376	2.58256438507093	GADD45G/FOS/PIK3CB/CSF2RB/ACTG1/MAP3K5/GADD45B/NFKBIA/LMNA/PIK3R1	3.18225325780833
Human Diseases	Cancer: specific types	hsa05214	Glioma	7/265	76/9376	3.25878848063555	GADD45G/PIK3CB/SOS2/CALM1/BRAF/GADD45B/PIK3R1	3.37183595963018
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	14/265	232/9376	2.13506831489915	PIK3CB/EZR/SOS2/BRAF/ACTG1/GSN/FGFR1/CRK/ARHGEF4/RAC1/RGCC/PIK3R1/CYFIP2/CHRM2	2.98554372627245
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	6/265	59/9376	3.59808122801407	GADD45G/PIK3CB/SOS2/BRAF/GADD45B/PIK3R1	3.41402136749012
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	5/265	42/9376	4.21203953279425	KMO/KYNU/GCDH/KYAT1/MAOA	3.55792820758252
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	8/265	98/9376	2.88825567963034	PIK3CB/CALM1/DGKG/IMPA2/IPMK/PIK3R1/INPP5B/DGKZ	3.20458802356911
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	8/265	98/9376	2.88825567963034	PIK3CB/GSN/DNM2/CRK/MYO10/RAC1/PIK3R1/GAB2	3.20458802356911
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	10/265	144/9376	2.45702306079665	INHBA/PIK3CB/DLX5/KLF4/LIFR/ID3/BMPR2/FGFR1/ID1/PIK3R1	3.00486749341633
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	13/265	216/9376	2.12941998602376	FOS/PIK3CB/HSPA1B/CALM1/LDLR/MAP3K5/CXCL1/ABCA1/HSPA8/NFKBIA/RAC1/HSPA1A/PIK3R1	2.86391523174616
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	8/265	106/9376	2.67027411890352	PIK3CB/SOS2/BRAF/FGFR1/ETV5/NFKBIA/FOXO1/PIK3R1	2.94935037827116
NA	NA	hsa04518	Integrin signaling	10/265	154/9376	2.29747610879686	FLT1/FLNB/PIK3CB/NPNT/ACTG1/LAMA5/LIMS2/LIMS1/RAC1/PIK3R1	2.7686797416379
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	8/265	110/9376	2.57317324185249	FLT1/PIK3CB/SERPINE1/EPAS1/EGLN3/HMOX1/PIK3R1/GAPDH	2.83042920912106
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	12/265	205/9376	2.07109065807639	GADD45G/PIK3CB/HDAC2/CALR/BLNK/HES1/GADD45B/PSMC5/NFKBIA/RAC1/PIK3R1/HLA-C	2.64435870884925
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	6/265	71/9376	2.9899548232793	CGA/FOS/PIK3CB/SOS2/LHB/PIK3R1	2.87038237368734
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	6/265	71/9376	2.9899548232793	CXCL1/JAM3/NFKBIA/ATP6V1C2/RAC1/ATP6V1F	2.87038237368734
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	5/265	52/9376	3.40203193033382	LDLR/ANGPTL4/SCARB1/LPL/ABCA1	2.96213513461797
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	3/265	19/9376	5.58649453823237	HEXB/HPSE2/HPSE	3.41283206305521
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	6/265	73/9376	2.9080382527785	GADD45G/PIK3CB/SOS2/BRAF/GADD45B/PIK3R1	2.79101743024683
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	12/265	212/9376	2.00270558917764	FLT1/PIK3CB/PRKD3/CALM1/BRAF/ACTG1/FGFR1/RAPGEF3/CRK/ID1/RAC1/PIK3R1	2.51839806970647
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	5/265	55/9376	3.21646655231561	ACER2/HEXB/CERS4/DEGS1/SPTLC3	2.81149182182116
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	4/265	37/9376	3.82498725140235	GALE/UGP2/PGM1/NANS	2.93624789512659
NA	NA	hsa04382	Cornified envelope formation	12/265	217/9376	1.95656029910443	KRT19/KRT23/LAMA5/KRT7/KRT8/KRT10/KRT15/S100A6/TCHH/PPP2R2B/SPTLC3/KAZN	2.43132906202553
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	5/265	56/9376	3.15902964959569	HSPA1B/CXCL1/HSPA8/NFKBIA/HSPA1A	2.76356838435272
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	6/265	77/9376	2.75697133055624	GADD45G/PIK3CB/BRAF/GADD45B/RAC1/PIK3R1	2.6400823003435
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	4/265	38/9376	3.72432969215492	GALE/UGP2/HEXB/PGM1	2.86978974348748
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	7/265	99/9376	2.50169620735658	FOS/PIK3CB/SOS2/DGKG/RAC1/PIK3R1/DGKZ	2.56165981065159
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	6/265	78/9376	2.72162554426705	PIK3CB/PIP5KL1/ISYNA1/IMPA2/IPMK/INPP5B	2.60385490348499
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	9/265	148/9376	2.15155532891382	GADD45G/FOS/PIK3CB/SOS2/BRAF/HES1/GADD45B/FGFR1/PIK3R1	2.4081715758576
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	7/265	103/9376	2.40454295658546	FOS/PIK3CB/SERPINE1/CALR/NFKBIA/PPP2R2B/PIK3R1	2.4443819073332
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	9/265	157/9376	2.02821776228819	SGK1/CALR/P2RY6/ATP8A2/ABCA1/CRK/RAC1/ADAM9/SIRPA	2.21573884996095
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	9/265	157/9376	2.02821776228819	LEP/FOS/PIK3CB/MAP3K5/RAC1/SREBF1/UQCRC1/PIK3R1/NDUFA6	2.21573884996095
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	6/265	86/9376	2.46845107503291	PIK3CB/SOS2/BRAF/CRK/PIK3R1/ERBB3	2.33306265484832
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	9/265	158/9376	2.01538094100788	PIK3CB/SOS2/SGK1/CASTOR2/BRAF/FNIP2/ATP6V1C2/PIK3R1/ATP6V1F	2.19515277363201
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	11/265	214/9376	1.8186563216364	FOS/PIK3CB/CALM1/CALR/TNFRSF1B/CRK/NFKBIA/AP1G2/RAC1/PIK3R1/HLA-C	2.06604089944688
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	8/265	138/9376	2.0510801203172	PIK3CB/SOS2/CALM1/BRAF/CRK/SREBF1/FOXO1/PIK3R1	2.12134809422089
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	8/265	138/9376	2.0510801203172	FOS/PIK3CB/ACTG1/CRK/ARHGEF28/NFKBIA/RAC1/PIK3R1	2.12134809422089
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	5/265	69/9376	2.5638501503965	PIK3CB/SOS2/RAC1/PIK3R1/GAB2	2.22351660195499
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	5/265	69/9376	2.5638501503965	FOS/FOSB/CALM1/HDAC2/MAOA	2.22351660195499
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	7/265	116/9376	2.13506831489915	PIK3CB/EZR/ACTG1/JAM3/RAPGEF3/RAC1/PIK3R1	2.09783368087673
NA	NA	hsa03272	Virion - Hepatitis viruses	4/265	48/9376	2.94842767295597	HSPG2/LDLR/CD63/SCARB1	2.30800205373082
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	6/265	93/9376	2.2826536822885	CGA/SOS2/MMP14/CALM1/MAP3K4/LHB	2.11998243773069
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	6/265	93/9376	2.2826536822885	GADD45G/PIK3CB/LAMA5/GADD45B/NFKBIA/PIK3R1	2.11998243773069
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	9/265	168/9376	1.89541778975741	LEP/PIK3CB/CSF2RB/SOS2/LIFR/OSMR/FHL1/PIK3R1/IL11RA	1.99720781103192
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	12/265	248/9376	1.71199026171637	FOS/SNX9/PIK3CB/ACTG1/RHOB/DNM2/GSDMD/DYNC2H1/NFKBIA/RAC1/CYFIP2/GAPDH	1.937927966596
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	7/265	122/9376	2.03006495515002	LEP/PIK3CB/PPP2R2B/SREBF1/FOXO1/PFKFB4/PIK3R1	1.95301388744116
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	7/265	122/9376	2.03006495515002	FOS/PIK3CB/SOS2/NFKBIA/PPP2R2B/MAP3K8/PIK3R1	1.95301388744116
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	7/265	122/9376	2.03006495515002	PIK3CB/ACTG1/HDAC2/DIO2/THRB/FOXO1/PIK3R1	1.95301388744116
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/265	14/9376	5.0544474393531	ST3GAL1/B4GALT1	2.58902906543851
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	6/265	98/9376	2.16619175972276	PRKD3/CALM1/HSD3B1/LDLR/SCARB1/CYP11A1	1.97916213715514
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	8/265	149/9376	1.8996580980119	PIK3CB/SOS2/DGKG/DNM2/RAPGEF3/PIK3R1/GAB2/DGKZ	1.88784319694053
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	10/265	203/9376	1.74291291012176	FLT1/FLNB/PIK3CB/SOS2/BRAF/ACTG1/LAMA5/CRK/RAC1/PIK3R1	1.8249702095257
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	5/265	76/9376	2.32770605759682	PLIN2/UBC/ANGPTL4/HMGCS2/LPL	1.98195053109362
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/265	15/9376	4.71748427672956	ST3GAL1/HEXB	2.45730576244503
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	8/265	155/9376	1.8261229458308	ACTG1/CALR/SCARB1/DYNC2H1/ATP6V1C2/RAC1/HLA-C/ATP6V1F	1.76867108125025
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/265	16/9376	4.42264150943396	ST3GAL1/HEXB	2.33673267770822
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	8/265	156/9376	1.81441702951137	PIK3CB/SOS2/BRAF/LDLR/SCARB1/NFKBIA/PPP2R2B/PIK3R1	1.74931990030141
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	5/265	80/9376	2.21132075471698	PIK3CB/SOS2/BRAF/PIK3R1/ERBB3	1.85558838879547
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/265	36/9376	2.94842767295597	UGP2/DCXR/AKR1B1	1.99750397957596
NA	NA	hsa04517	IgSF CAM signaling	13/265	299/9376	1.5383100902379	NLGN1/NECTIN4/PIK3CB/EZR/LRFN5/ACTG1/JAM3/FGFR1/NLGN4X/MYL6/RAC1/FOXO1/PIK3R1	1.6133273591272
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	5/265	82/9376	2.15738610216291	HSPA1B/CALR/HSPA8/HSPA1A/HLA-C	1.79518581132723
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	4/265	59/9376	2.39872081867605	CGA/PIK3CB/PIK3R1/ADORA1	1.83799594509346
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	3/265	37/9376	2.86874043855176	GADD45G/BRAF/GADD45B	1.94233980224573
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	6/265	109/9376	1.94758525186083	FOS/PIK3CB/NFKBIA/RAC1/MAP3K8/PIK3R1	1.6970221547006
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	4/265	60/9376	2.35874213836478	PIK3CB/HSPB1/RAC1/PIK3R1	1.80062585315834
Human Diseases	Infectious disease: viral	hsa05162	Measles	7/265	136/9376	1.82108768035516	FOS/PIK3CB/HSPA1B/HSPA8/NFKBIA/HSPA1A/PIK3R1	1.64493429948291
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	6/265	110/9376	1.92987993138937	INHBA/GREM2/ID3/HDAC2/BMPR2/ID1	1.67302573471227
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	6/265	110/9376	1.92987993138937	SPDYE2/PIK3CB/BRAF/CDC26/PIK3R1/SPDYE3	1.67302573471227
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	3/265	38/9376	2.79324726911619	PIK3CB/SGK1/PIK3R1	1.88899406531665
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	9/265	193/9376	1.64989735066966	PIK3CB/SOS2/BRAF/CXCL1/DOCK2/CRK/NFKBIA/RAC1/PIK3R1	1.55581043758684
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	11/265	250/9376	1.55676981132075	HSPA1B/PIP5KL1/RNF103-CHMP3/DAB2/LDLR/DNM2/HSPA8/RAB11A/IGF2R/HSPA1A/HLA-C	1.52170687687196
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	6/265	112/9376	1.89541778975741	HSPA1B/LDLR/LAMA5/HSPA8/NFKBIA/HSPA1A	1.62577712440393
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	9/265	196/9376	1.62464381979207	FOS/PIK3CB/CALM1/UBC/CXCL1/NFKBIA/RAC1/PIK3R1/HLA-C	1.50717851425904
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/265	20/9376	3.53811320754717	UGP2/NANS	1.93778875852854
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	8/265	170/9376	1.66499445061043	EZR/ACTG1/MAP3K5/JAM3/MYL6/CTTN/PPP2R2B/RAC1	1.49221894140408
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	4/265	65/9376	2.17730043541364	DGKG/LPL/AKR1B1/DGKZ	1.62431917620694
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	4/265	65/9376	2.17730043541364	HSD3B1/LDLR/SCARB1/CYP11A1	1.62431917620694
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	4/265	65/9376	2.17730043541364	CGA/PIK3CB/LHB/PIK3R1	1.62431917620694
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	9/265	200/9376	1.59215094339623	FOS/EZR/ACTG1/CTTN/MYO10/NFKBIA/RAC1/CYFIP2/GAPDH	1.44359800349325
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	6/265	117/9376	1.81441702951137	ACTG1/HDAC2/SMARCA2/SMARCB1/SMARCC2/SMARCA1	1.51176152056889
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	9/265	201/9376	1.58422979442411	FLT1/GADD45G/BCL6/HDAC2/GADD45B/ETV5/DDX5/MITF/FOXO1	1.4279212126461
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	8/265	173/9376	1.63612171447268	PIK3CB/DNAJB1/ACTG1/RAB11A/NFKBIA/SLC25A6/PIK3R1/SLC25A4	1.44020433293102
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	4/265	68/9376	2.08124306326304	PIK3CB/SOS2/BRAF/PIK3R1	1.52607246052543
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	3/265	44/9376	2.41234991423671	MAN1C1/HEXB/B4GALT1	1.60142584403872
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	3/265	44/9376	2.41234991423671	AQP3/RAB11A/DYNC2H1	1.60142584403872
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	5/265	95/9376	1.86216484607746	FLT1/FOS/CXCL1/ATP6V1C2/ATP6V1F	1.44039060201469
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	6/265	122/9376	1.74005567584287	FOS/JUNB/PIK3CB/SOS2/CRK/PIK3R1	1.40315327220339
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	7/265	150/9376	1.65111949685535	GADD45G/PIK3CB/SOS2/BRAF/ABCB1/GADD45B/PIK3R1	1.37096117556225
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	4/265	70/9376	2.02177897574124	ACTG1/DMD/RAC1/HLA-C	1.46335605900836
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	15/265	388/9376	1.36782727095896	PIK3CB/MME/CALM1/BRAF/BACE2/MAP3K5/LPL/PSMC5/UQCRC1/SLC25A6/PIK3R1/GAPDH/CSNK1E/SLC25A4/NDUFA6	1.26198388082738
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/265	23/9376	3.0766201804758	LARGE1/B4GALT1	1.70047821624946
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/265	23/9376	3.0766201804758	PREP/MME	1.70047821624946
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	12/265	298/9376	1.42474357350893	LEP/EBI3/INHBA/GDF15/CSF2RB/LIFR/OSMR/BMPR2/CXCL1/TNFRSF1B/INHA/IL11RA	1.27076548717581
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	7/265	154/9376	1.6082332761578	RDH13/KMO/KYNU/QPRT/UGP2/MTHFD1L/GPHN	1.29790686585337
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	5/265	99/9376	1.78692586239756	FOS/PIK3CB/SOS2/BRAF/PIK3R1	1.34237294187126
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	3/265	48/9376	2.21132075471698	PIK3CB/SLC2A5/PIK3R1	1.43486505987268
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	11/265	275/9376	1.41524528301887	PIK3CB/HSPA1B/HSPA8/PSMC5/RAC1/HSPA1A/UQCRC1/SLC25A6/PIK3R1/SLC25A4/NDUFA6	1.19193356397576
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	7/265	157/9376	1.57750270400192	SERPINE1/ACTG1/LIMD1/BMPR2/ID1/PPP2R2B/CSNK1E	1.24447877107954
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	5/265	101/9376	1.75154119185503	PIK3CB/SERPINE1/RAC1/FOXO1/PIK3R1	1.29503667834236
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	4/265	75/9376	1.88699371069182	PIK3CB/MGST3/MAP3K5/PIK3R1	1.31526087629025
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	5/265	103/9376	1.71753068327533	PIK3CB/HSPB1/LAMA5/CXCL1/PIK3R1	1.24874715431883
NA	NA	hsa04081	Hormone signaling	9/265	219/9376	1.45401912638925	CGA/LEP/PIK3CB/CRH/DIO2/RAPGEF3/LHB/THRB/PIK3R1	1.15943164830579
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	3/265	51/9376	2.08124306326304	ACTG1/ATP6V1C2/ATP6V1F	1.32041227770253
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	6/265	133/9376	1.59614129663782	PIK3CB/SOS2/BRAF/RAC1/PIK3R1/HLA-C	1.18084828632105
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	5/265	105/9376	1.6848158131177	GADD45G/BLNK/CXCL1/GADD45B/NFKBIA	1.20345731472291
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	5/265	105/9376	1.6848158131177	PIK3CB/CALM1/PLK3/NFKBIA/PIK3R1	1.20345731472291
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	7/265	163/9376	1.51943511980553	FOS/HSPG2/PIK3CB/SOS2/BRAF/NFKBIA/PIK3R1	1.14090669350995
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	10/265	253/9376	1.39846371839809	PIK3CB/ACTG1/UBC/CRK/CTTN/NFKBIA/RAC1/FOXO1/PIK3R1/FNBP1L	1.09573556589851
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	9/265	224/9376	1.42156334231806	FOS/PIK3CB/CALR/NFKBIA/CDC26/SLC25A6/PIK3R1/SLC25A4/HLA-C	1.0890664879039
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/265	28/9376	2.52722371967655	B3GNT5/B4GALT1	1.38021860163053
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/265	28/9376	2.52722371967655	GPHN/AKR1B1	1.38021860163053
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	2/265	28/9376	2.52722371967655	ATP6V1C2/ATP6V1F	1.38021860163053
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	8/265	195/9376	1.4515336236091	PIK3CB/ACTG1/HDAC2/GSDMD/RAC1/SLC25A6/PIK3R1/SLC25A4	1.08664568447918
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	3/265	53/9376	2.00270558917764	DNM2/RAB11A/TRPV5	1.24841529352852
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	9/265	227/9376	1.40277616158258	PIK3CB/SOS2/CALM1/CALR/CRK/NFKBIA/RAC1/PIK3R1/HLA-C	1.04764808976204
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	5/265	109/9376	1.62298770988402	PIK3CB/NFKBIA/SREBF1/FOXO1/PIK3R1	1.11570325066082
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/265	29/9376	2.44007807417046	LIMD1/CSNK1E	1.32456863673197
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	3/265	56/9376	1.89541778975741	MAN1C1/MGAT3/B4GALT1	1.1461390977303
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	9/265	235/9376	1.35502207948615	SOS2/ACTG1/MAP3K5/SMARCA2/FGFR1/SMARCB1/UQCRC1/SMARCC2/NDUFA6	0.939978655487106
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	6/265	144/9376	1.47421383647799	MAP3K5/CXCL1/ACADVL/NFKBIA/SREBF1/FOXO1	0.977987089224134
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	6/265	144/9376	1.47421383647799	PIK3CB/MAP3K5/PSMC5/SLC25A6/PIK3R1/SLC25A4	0.977987089224134
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	8/265	205/9376	1.38072710538426	PIK3CB/RAC1/UQCRC1/SLC25A6/PIK3R1/GAPDH/SLC25A4/NDUFA6	0.939956883412602
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	13/265	362/9376	1.27059314083186	FLT1/PIK3CB/SOS2/SGK1/LAMA5/OSMR/FGFR1/PIK3AP1/PPP2R2B/RAC1/PIK3R1/ERBB3/CHRM2	0.895442789908767
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	10/265	268/9376	1.32019149535342	DUSP1/CALM1/UBC/MAP3K5/MAOA/PSMC5/UQCRC1/SLC25A6/SLC25A4/NDUFA6	0.906966466919348
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	12/265	333/9376	1.27499575046745	PIK3CB/SOS2/HDAC2/LAMA5/HES1/MAML2/ATP6V1C2/PPP2R2B/FOXO1/PIK3R1/HLA-C/ATP6V1F	0.871399659451423
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	4/265	89/9376	1.59016323934704	HSPG2/NPNT/LAMA5/SDC1	0.95401452435649
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	7/265	180/9376	1.37593291404612	PIK3CB/PILRB/CALR/SRSF7/NFKBIA/PIK3R1/HLA-C	0.868505702380353
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/265	34/9376	2.08124306326304	BHLHE40/CSNK1E	1.07713072226207
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	4/265	90/9376	1.57249475890985	FOS/PIK3CB/NFKBIA/PIK3R1	0.930687716593472
NA	NA	hsa04519	Cadherin signaling	14/265	404/9376	1.22607883429852	KRT19/ACTG1/LIMD1/KRT23/KRT7/KRT8/KRT10/KRT15/FGFR1/FMN1/NFKBIA/RAC1/CYFIP2/TMC4	0.792193924091059
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	3/265	62/9376	1.71199026171637	HDAC2/HES1/MAML2	0.959240117026322
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/265	35/9376	2.02177897574124	AKR1B1/PFKFB4	1.03280861132404
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	3/265	63/9376	1.6848158131177	GCDH/KMT2E/CAMKMT	0.930089636314649
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	4/265	93/9376	1.52176912152566	NECTIN4/ACTG1/FGFR1/RAC1	0.862385061110971
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/265	36/9376	1.96561844863732	UGP2/PGM1	0.989940104360541
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	8/265	217/9376	1.30437353273628	FOS/PIK3CB/SOS2/KLF4/BCL6/MGST3/PAQR7/PIK3R1	0.77363885637524
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	6/265	155/9376	1.3695922093731	CRH/BRAF/HSD3B1/LDLR/SCARB1/CYP11A1	0.791270906918339
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	4/265	94/9376	1.50558008831794	FOS/FOSB/CXCL1/NFKBIA	0.840153533040299
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/265	37/9376	1.91249362570117	MAOA/FAHD1	0.948431709364872
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3/265	66/9376	1.6082332761578	HSD3B1/STS/CYP11A1	0.845654288542904
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/265	12/9376	2.94842767295597	NECTIN4	1.15178060594317
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	3/265	67/9376	1.58422979442411	CALM1/BRAF/RAPGEF3	0.818455627795427
Human Diseases	Substance dependence	hsa05034	Alcoholism	7/265	191/9376	1.29669070433666	FOSB/SOS2/CRH/CALM1/BRAF/HDAC2/MAOA	0.706490936552742
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	6/265	160/9376	1.32679245283019	NLGN1/SDC3/JAM3/NLGN4X/SDC1/HLA-C	0.711027385734459
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	2/265	39/9376	1.81441702951137	MTHFD1L/MTHFS	0.869162583548005
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	11/265	323/9376	1.20493019452071	PIK3CB/EZR/SOS2/TIMP3/HDAC2/BMPR2/ABCB1/CRK/HMOX1/PIK3R1/ERBB3	0.639199615581445
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	5/265	130/9376	1.36081277213353	FOS/PIK3CB/SOS2/NFKBIA/PIK3R1	0.706483764413636
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	4/265	99/9376	1.42954068991805	PIK3CB/CALM1/TRPV4/PIK3R1	0.732729507481098
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	4/265	99/9376	1.42954068991805	KRT19/KRT23/KRT10/KRT15	0.732729507481098
Cellular Processes	Cell motility	hsa04814	Motor proteins	7/265	194/9376	1.27663878622836	MYO7B/KIF2A/ACTG1/MYL6/DYNC2H1/MYO10/KIF26B	0.664004225432015
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	3/265	70/9376	1.51633423180593	LEP/TNFRSF1B/NFKBIA	0.73947580105424
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	3/265	71/9376	1.49497741163965	PIK3CB/FGFR1/PIK3R1	0.71397321241821
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	2/265	42/9376	1.6848158131177	SAT1/HMOX1	0.758560246103329
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	8/265	233/9376	1.21480281804195	HSPG2/ACTG1/COL27A1/DMD/SDC3/FHL1/LMNA/SDC1	0.566238150993602
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	2/265	43/9376	1.64563405002194	GCDH/ACADVL	0.723661675297132
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/265	43/9376	1.64563405002194	SCARB1/ABCA1	0.723661675297132
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	5/265	138/9376	1.28192507519825	ATP12A/ATP6V1C2/UQCRC1/NDUFA6/ATP6V1F	0.568996796176111
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	3/265	75/9376	1.41524528301887	GADD45G/SERPINE1/GADD45B	0.615738159397778
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	8/265	238/9376	1.18928175043602	FLT1/PIK3CB/SOS2/CALM1/FGFR1/RAC1/PIK3R1/GAB2	0.504425690397845
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	7/265	205/9376	1.20813621721123	PIK3CB/HDAC2/GSN/NFKBIA/RAC1/PIK3R1/HLA-C	0.51385642705344
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	3/265	76/9376	1.39662363455809	EZR/CALM1/ACTG1	0.592065102557063
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/265	45/9376	1.57249475890985	ABCB1/ABCA1	0.656506800537962
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/265	16/9376	2.21132075471698	MAOA	0.827002414051091
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	2/265	47/9376	1.50558008831794	PIK3CB/PIK3R1	0.592579871832563
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/265	17/9376	2.08124306326304	CDO1	0.760954383518672
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/265	17/9376	2.08124306326304	KYAT1	0.760954383518672
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	3/265	79/9376	1.34358729400525	DNM2/ATP6V1C2/ATP6V1F	0.523003719009946
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/265	18/9376	1.96561844863732	HEXB	0.699319822331778
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	2/265	49/9376	1.44412783981517	FUT10/B4GALT1	0.531570168991436
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	2/265	49/9376	1.44412783981517	FOSB/MAOA	0.531570168991436
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	4/265	115/9376	1.23064807219032	FOS/PIK3CB/PIK3R1/CHRM2	0.424419528884574
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	4/265	115/9376	1.23064807219032	DUSP1/BRAF/RAPGEF3/MAOA	0.424419528884574
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	8/265	250/9376	1.13219622641509	CD63/HEXB/AP3S1/IGF2R/MITF/AP1G2/ATP6V1C2/ATP6V1F	0.361305341529162
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	2/265	50/9376	1.41524528301887	SAT1/MAOA	0.502073796886637
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	6/265	184/9376	1.15373256767842	PIK3CB/BMPR2/SEMA4C/SEMA4B/RAC1/PIK3R1	0.359166097959413
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/265	20/9376	1.76905660377358	FDFT1	0.58715633212625
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	3/265	86/9376	1.23422553751645	ACTG1/DMD/LMNA	0.372135554042321
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	2/265	54/9376	1.31041229909154	KYAT1/CDO1	0.3901277139789
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	2/265	54/9376	1.31041229909154	HES1/CENPX	0.3901277139789
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	2/265	54/9376	1.31041229909154	CGA/HLA-C	0.3901277139789
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	5/265	158/9376	1.11965607833771	GADD45G/HDAC2/CCNH/GADD45B/CDC26	0.258684560283585
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/265	22/9376	1.6082332761578	MAOA	0.487089071815375
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	3/265	90/9376	1.17937106918239	PIK3CB/FOXO1/PIK3R1	0.291598216756033
Organismal Systems	Digestive system	hsa04976	Bile secretion	3/265	90/9376	1.17937106918239	LDLR/ABCB1/SCARB1	0.291598216756033
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	11/265	370/9376	1.05187149413565	CGA/LEP/P2RY14/ADM/CRH/GRIK1/P2RY6/LHB/THRB/CHRM2/ADORA1	0.173615781835265
Human Diseases	Substance dependence	hsa05032	Morphine addiction	3/265	91/9376	1.16641094754302	PDE4D/PDE10A/ADORA1	0.272042769478974
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	2/265	57/9376	1.2414432307183	TECR/ACADVL	0.311812382424485
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/265	23/9376	1.5383100902379	GPT2	0.440805011259736
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/265	23/9376	1.5383100902379	HMGCS2	0.440805011259736
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	4/265	128/9376	1.10566037735849	PDE4D/GUK1/PGM1/PDE10A	0.205266833837559
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	3/265	93/9376	1.14132684114425	FOS/MAML2/NFKBIA	0.233586372801113
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/265	24/9376	1.47421383647799	EXT1	0.396691728656798
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	2/265	59/9376	1.19936040933802	PRDX6/MGST3	0.2619705226968
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/265	60/9376	1.17937106918239	CRH/BRAF	0.237705282966468
Organismal Systems	Digestive system	hsa04978	Mineral absorption	2/265	61/9376	1.16003711722858	SLC26A6/HMOX1	0.213855172764734
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	4/265	133/9376	1.06409419775855	FOS/CALM1/MAOA/PPP2R2B	0.126959034734151
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/265	26/9376	1.36081277213353	HES1	0.314187080565358
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/265	26/9376	1.36081277213353	SCARB1	0.314187080565358
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	4/265	134/9376	1.05615319628274	ADM/CALM1/BRAF/MYL6	0.111652756794954
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	3/265	99/9376	1.07215551743854	ACTG1/DMD/LMNA	0.123086073090932
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/265	63/9376	1.12321054207847	GADD45G/GADD45B	0.167339664296268
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/265	27/9376	1.31041229909154	HMGCS2	0.27546331810339
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/265	27/9376	1.31041229909154	TECR	0.27546331810339
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	4/265	138/9376	1.0255400601586	SPDYE2/CALM1/CDC26/SPDYE3	0.0515463634945188
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/265	28/9376	1.26361185983827	TECR	0.238237520719142
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/265	29/9376	1.22003903708523	CALM1	0.20238958748656
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	2/265	67/9376	1.05615319628274	PGM1/GAPDH	0.0786657920478204
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	4/265	142/9376	0.996651607759766	RHOBTB1/UBC/MID1/CDC26	-0.00685663633402011
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	3/265	105/9376	1.01088948787062	UBC/MTX1/MITF	0.0191365818085039
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	3/265	105/9376	1.01088948787062	ACTG1/DMD/LMNA	0.0191365818085039
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	7/265	254/9376	0.975070569009063	FLT1/CALM1/FGFR1/SLC25A6/ERBB3/SLC25A4/CHRM2	-0.0686925663892965
Organismal Systems	Endocrine system	hsa04924	Renin secretion	2/265	69/9376	1.0255400601586	CALM1/ADORA1	0.0363134202872174
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/265	31/9376	1.14132684114425	PGM1	0.134413038235133
NA	NA	hsa04981	Folate transport and metabolism	1/265	31/9376	1.14132684114425	MTHFS	0.134413038235133
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	3/265	109/9376	0.973792625930414	FOS/EBI3/NFKBIA	-0.0469345574187407
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/265	32/9376	1.10566037735849	ATG4B	0.102104829283078
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/265	33/9376	1.07215551743854	GPT2	0.0708123313371949
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/265	73/9376	0.969346084259499	MGST3/MAOA	-0.0448395691294296
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	2/265	75/9376	0.943496855345912	GPT2/GAPDH	-0.0837845574946935
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	4/265	154/9376	0.918990443518745	FOS/CALM1/ACTG1/MYL6	-0.17286600993116
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/265	36/9376	0.982809224318658	ST3GAL1	-0.0176237708548773
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	8/265	308/9376	0.918990443518745	HDAC2/MAP3K5/TGM2/PSMC5/UQCRC1/SLC25A6/SLC25A4/NDUFA6	-0.246536603705229
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	2/265	78/9376	0.907208514755685	FOS/CALM1	-0.140341530514365
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	2/265	78/9376	0.907208514755685	FOS/NFKBIA	-0.140341530514365
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/265	37/9376	0.956246812850586	GPT2	-0.0454763835159864
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/265	38/9376	0.931082423038729	QPRT	-0.0725972910250167
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/265	38/9376	0.931082423038729	BLNK	-0.0725972910250167
NA	NA	hsa04082	Neuroactive ligand signaling	5/265	199/9376	0.88897316772542	P2RY14/GRIK1/P2RY6/CHRM2/ADORA1	-0.269978806591357
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/265	39/9376	0.907208514755685	HLA-C	-0.0990289791638989
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	2/265	82/9376	0.862954440865163	UCK2/MGST3	-0.212567131058946
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	2/265	83/9376	0.852557399408957	BCORL1/HDAC2	-0.230096287628861
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	2/265	83/9376	0.852557399408957	GSDMD/NFKBIA	-0.230096287628861
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/265	41/9376	0.862954440865163	MAOA	-0.149977215500483
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	1/265	41/9376	0.862954440865163	RAD51B	-0.149977215500483
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	1/265	41/9376	0.862954440865163	BRAF	-0.149977215500483
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	4/265	166/9376	0.852557399408957	CALM1/SLC25A6/SLC25A4/ADORA1	-0.326868268992794
Organismal Systems	Immune system	hsa04611	Platelet activation	3/265	126/9376	0.84240790655885	PIK3CB/ACTG1/PIK3R1	-0.30372069341713
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	2/265	85/9376	0.832497225305216	UCK2/GUK1	-0.264560979740608
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	4/265	169/9376	0.837423244389863	PIK3CB/UBC/ATG4B/PIK3R1	-0.363720923480048
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	12/265	480/9376	0.884528301886792	CALM1/BRAF/UBC/MAP3K5/TNFRSF1B/PSMC5/RAC1/UQCRC1/SLC25A6/CSNK1E/SLC25A4/NDUFA6	-0.442919025747869
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	2/265	88/9376	0.804116638078902	SERPINE1/PROCR	-0.314849736163534
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/265	44/9376	0.804116638078902	CCNH	-0.222106912058807
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/265	44/9376	0.804116638078902	SMUG1	-0.222106912058807
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	1/265	44/9376	0.804116638078902	HLA-C	-0.222106912058807
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/265	45/9376	0.786247379454927	HLA-C	-0.24512023356837
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/265	46/9376	0.76915504511895	HMOX1	-0.267660344931594
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	1/265	46/9376	0.76915504511895	PSMC5	-0.267660344931594
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/265	48/9376	0.737106918238994	HMGCS2	-0.311408927843603
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	1/265	50/9376	0.707622641509434	SDC1	-0.353513974761693
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	2/265	97/9376	0.729507877844777	FOS/CALM1	-0.456683638801468
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	2/265	100/9376	0.707622641509434	CXCL1/TNFRSF1B	-0.501289860120504
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	2/265	100/9376	0.707622641509434	MME/IL11RA	-0.501289860120504
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	2/265	101/9376	0.700616476742014	CALM1/MITF	-0.515890077233773
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	2/265	102/9376	0.693747687754347	RAB11A/RAC1	-0.530360862628974
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	2/265	103/9376	0.68701227331013	MME/COL27A1	-0.544704975202743
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	2/265	104/9376	0.680406386066764	DGKG/DGKZ	-0.558925086564698
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	1/265	56/9376	0.631805929919137	CSNK1E	-0.471290188892112
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	5/265	238/9376	0.743301094022515	FOS/PIK3CB/RPL10A/NFKBIA/PIK3R1	-0.684088786022877
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	2/265	107/9376	0.661329571504144	CALM1/FOXO1	-0.600866894735451
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	3/265	154/9376	0.689242832639059	CALM1/RAPGEF3/PPP2R2B	-0.66312363519267
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/265	59/9376	0.599680204669012	UCK2	-0.52604218850153
Genetic Information Processing	Transcription	hsa03040	Spliceosome	5/265	243/9376	0.728006832828636	HSPA1B/SRSF7/HSPA8/DDX5/HSPA1A	-0.732621996514935
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	8/265	368/9376	0.76915504511895	ACTG1/MAP3K5/SRSF7/TNFRSF1B/PSMC5/RAC1/UQCRC1/NDUFA6	-0.770469870087381
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/265	63/9376	0.561605271039233	CCNH	-0.595410307722113
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	2/265	116/9376	0.610019518542615	GPT2/GAPDH	-0.720762070570623
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	2/265	116/9376	0.610019518542615	SHANK2/GRIK1	-0.720762070570623
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/265	68/9376	0.52031076581576	RDH13	-0.677036047463652
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	3/265	168/9376	0.631805929919137	RNF103-CHMP3/SLC25A6/SLC25A4	-0.821248004175076
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	1/265	70/9376	0.50544474393531	MGST3	-0.708284714853998
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	1/265	72/9376	0.491404612159329	NFKBIA	-0.738804218739519
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	1/265	73/9376	0.484673042129749	SMARCB1	-0.753803818973495
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	3/265	178/9376	0.596311214755141	LGR4/RAC1/CSNK1E	-0.927332615935361
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	1/265	75/9376	0.471748427672956	CGA	-0.783307274387165
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/265	79/9376	0.447862431335085	MGST3	-0.840455997224519
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	3/265	187/9376	0.567611744526284	CXCL1/GSDMD/NFKBIA	-1.01855883097966
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	2/265	140/9376	0.50544474393531	SERPINE1/CALM1	-1.00545451674748
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	1/265	87/9376	0.40667967902841	UQCRC1	-0.94817809887325
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	1/265	89/9376	0.397540809836761	SOS2	-0.973891254873293
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	1/265	89/9376	0.397540809836761	GPHN	-0.973891254873293
Organismal Systems	Digestive system	hsa04970	Salivary secretion	1/265	93/9376	0.380442280381416	CALM1	-1.0240110038186
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	1/265	103/9376	0.343506136655065	PPP2R2B	-1.14252235170993
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	2/265	181/9376	0.390951735640571	CALM1/PLK3	-1.41104440939496
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	1/265	149/9376	0.237457262251488	NDUFA6	-1.60012022680186
Genetic Information Processing	Translation	hsa03010	Ribosome	2/265	222/9376	0.318748937616862	RPL10A/MRPL55	-1.7518776723183
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	1/265	183/9376	0.193339519538097	NVL	-1.87937414282828
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/265	449/9376	0.0787998487204269	CALM1	-3.41153597700931