ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0097110 scaffold protein binding 10/503 70/18639 0.142857142857143 5.29366657199659 1.74003208101421e-05 0.0154340845585961 GO:0003995 acyl-CoA dehydrogenase activity 4/503 12/18639 0.333333333333333 12.351888667992 0.000218338705345965 0.049533380839033 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 4/503 12/18639 0.333333333333333 12.351888667992 0.000218338705345965 0.049533380839033 GO:0140416 transcription regulator inhibitor activity 6/503 33/18639 0.181818181818182 6.73739381890475 0.000223374885407139 0.049533380839033 GO:0017124 SH3 domain binding 11/503 115/18639 0.0956521739130435 3.54445500907598 0.000281671901894906 0.0499685953961564 GO:0004709 MAP kinase kinase kinase activity 5/503 25/18639 0.2 7.41113320079523 0.000476629921659971 0.0652484549749442 GO:0050660 flavin adenine dinucleotide binding 9/503 86/18639 0.104651162790698 3.87791853529983 0.000514925800253224 0.0652484549749442 GO:0001727 lipid kinase activity 6/503 41/18639 0.146341463414634 5.42278039082578 0.000755701241674333 0.0837883751706417 GO:0043236 laminin binding 5/503 29/18639 0.172413793103448 6.38890793172003 0.000974786777450544 0.0899173443090458 GO:0001786 phosphatidylserine binding 7/503 59/18639 0.11864406779661 4.39643494962429 0.00101372428758789 0.0899173443090458 GO:0034185 apolipoprotein binding 4/503 18/18639 0.222222222222222 8.23459244532803 0.00118673095267621 0.0956936686385274 GO:0008017 microtubule binding 17/503 276/18639 0.0615942028985507 2.28241421038984 0.00141529578168686 0.102382931041304 GO:0031625 ubiquitin protein ligase binding 18/503 302/18639 0.0596026490066225 2.20861585454162 0.00150053901187932 0.102382931041304 GO:0045296 cadherin binding 19/503 334/18639 0.0568862275449102 2.10795704813038 0.00191992949158757 0.121641247074155 GO:0044389 ubiquitin-like protein ligase binding 18/503 322/18639 0.0559006211180124 2.07143474556388 0.00300836871043092 0.176830815805812 GO:0072341 modified amino acid binding 8/503 91/18639 0.0879120879120879 3.25764096738252 0.00318973286684667 0.176830815805812 GO:0019838 growth factor binding 10/503 136/18639 0.0735294117647059 2.72468132382178 0.00384986717963889 0.197615802451593 GO:0005085 guanyl-nucleotide exchange factor activity 14/503 230/18639 0.0608695652173913 2.2555622785029 0.00401024176339197 0.197615802451593 GO:1990782 protein tyrosine kinase binding 9/503 117/18639 0.0769230769230769 2.8504358464597 0.00445019360911627 0.206511819438614 GO:0042169 SH2 domain binding 5/503 41/18639 0.121951219512195 4.51898365902148 0.00471924589888216 0.206511819438614 GO:0052742 phosphatidylinositol kinase activity 4/503 26/18639 0.153846153846154 5.70087169291941 0.00488923135085782 0.206511819438614 GO:0008375 acetylglucosaminyltransferase activity 5/503 43/18639 0.116279069767442 4.30879837255537 0.00580123231535904 0.233895139260158 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 23/503 484/18639 0.0475206611570248 1.76090974812283 0.00652185479551571 0.248313779661398 GO:0140776 protein-containing complex destabilizing activity 3/503 15/18639 0.2 7.41113320079523 0.00697876409842791 0.248313779661398 GO:0001216 DNA-binding transcription activator activity 23/503 491/18639 0.0468431771894094 1.73580512849583 0.00769259363747994 0.248313779661398 GO:0030291 protein serine/threonine kinase inhibitor activity 5/503 46/18639 0.108695652173913 4.02778978304088 0.0077350248751874 0.248313779661398 GO:0000062 fatty-acyl-CoA binding 3/503 16/18639 0.1875 6.94793737574553 0.00841923715505913 0.248313779661398 GO:0140328 floppase activity 3/503 16/18639 0.1875 6.94793737574553 0.00841923715505913 0.248313779661398 GO:0015631 tubulin binding 19/503 385/18639 0.0493506493506494 1.828721179417 0.00875681027464961 0.248313779661398 GO:0031072 heat shock protein binding 9/503 131/18639 0.0687022900763359 2.54580911477699 0.00917750460145265 0.248313779661398 GO:0106310 protein serine kinase activity 18/503 361/18639 0.0498614958448753 1.84765093648635 0.00956053739762065 0.248313779661398 GO:0005179 hormone activity 9/503 132/18639 0.0681818181818182 2.52652268208928 0.00962165140917413 0.248313779661398 GO:0004222 metalloendopeptidase activity 8/503 110/18639 0.0727272727272727 2.6949575275619 0.00989724067580466 0.248313779661398 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 3/503 17/18639 0.176470588235294 6.53923517717226 0.0100212925676643 0.248313779661398 GO:1901567 fatty acid derivative binding 3/503 17/18639 0.176470588235294 6.53923517717226 0.0100212925676643 0.248313779661398 GO:0071813 lipoprotein particle binding 4/503 32/18639 0.125 4.63195825049702 0.0103580719813661 0.248313779661398 GO:0071814 protein-lipid complex binding 4/503 32/18639 0.125 4.63195825049702 0.0103580719813661 0.248313779661398 GO:0004706 JUN kinase kinase kinase activity 3/503 18/18639 0.166666666666667 6.17594433399602 0.0117882048906619 0.275161519421503 GO:0030159 signaling receptor complex adaptor activity 5/503 52/18639 0.0961538461538462 3.56304480807463 0.0128633363716709 0.283068653809179 GO:0051219 phosphoprotein binding 7/503 93/18639 0.0752688172043011 2.78913615083691 0.0129110469036302 0.283068653809179 GO:0140297 DNA-binding transcription factor binding 22/503 488/18639 0.0450819672131148 1.67054231985138 0.0136022592677569 0.283068653809179 GO:0005346 purine ribonucleotide transmembrane transporter activity 3/503 19/18639 0.157894736842105 5.85089463220676 0.0137226066671868 0.283068653809179 GO:0120227 acyl-CoA binding 3/503 19/18639 0.157894736842105 5.85089463220676 0.0137226066671868 0.283068653809179 GO:0048029 monosaccharide binding 6/503 74/18639 0.0810810810810811 3.00451345978185 0.0148038393918971 0.298431944104835 GO:0044183 protein folding chaperone 6/503 75/18639 0.08 2.96445328031809 0.0157363099659186 0.310180154217107 GO:0017022 myosin binding 6/503 76/18639 0.0789473684210526 2.92544731610338 0.0167086380814444 0.318349111071494 GO:0051082 unfolded protein binding 8/503 121/18639 0.0661157024793388 2.44996138869264 0.0168685549271254 0.318349111071494 GO:0010314 phosphatidylinositol-5-phosphate binding 3/503 21/18639 0.142857142857143 5.29366657199659 0.0181014452038527 0.321119637916347 GO:0036122 BMP binding 3/503 21/18639 0.142857142857143 5.29366657199659 0.0181014452038527 0.321119637916347 GO:0051428 peptide hormone receptor binding 3/503 21/18639 0.142857142857143 5.29366657199659 0.0181014452038527 0.321119637916347 GO:0019887 protein kinase regulator activity 13/503 255/18639 0.0509803921568627 1.88911238451643 0.0215356728294822 0.360519636403963 GO:0030971 receptor tyrosine kinase binding 6/503 81/18639 0.0740740740740741 2.74486414844268 0.0221936797942448 0.360519636403963 GO:0071949 FAD binding 4/503 40/18639 0.1 3.70556660039761 0.0222519108129693 0.360519636403963 GO:0098531 ligand-modulated transcription factor activity 5/503 60/18639 0.0833333333333333 3.08797216699801 0.0227173721419788 0.360519636403963 GO:0031490 chromatin DNA binding 8/503 128/18639 0.0625 2.31597912524851 0.0228260384121627 0.360519636403963 GO:0003714 transcription corepressor activity 11/503 204/18639 0.053921568627451 1.9980996374693 0.0229910459484051 0.360519636403963 GO:0000295 adenine nucleotide transmembrane transporter activity 3/503 23/18639 0.130434782608696 4.83334773964906 0.0231675527339638 0.360519636403963 GO:0019207 kinase regulator activity 14/503 287/18639 0.0487804878048781 1.80759346360859 0.0244671161486289 0.362249763654086 GO:0030695 GTPase regulator activity 21/503 489/18639 0.0429447852760736 1.59134761980266 0.0251936121278296 0.362249763654086 GO:0060589 nucleoside-triphosphatase regulator activity 21/503 490/18639 0.0428571428571429 1.58809997159898 0.0256859897487649 0.362249763654086 GO:0030552 cAMP binding 3/503 24/18639 0.125 4.63195825049702 0.0259592088467891 0.362249763654086 GO:0070300 phosphatidic acid binding 3/503 24/18639 0.125 4.63195825049702 0.0259592088467891 0.362249763654086 GO:0004860 protein kinase inhibitor activity 6/503 84/18639 0.0714285714285714 2.6468332859983 0.0260077529781564 0.362249763654086 GO:0031492 nucleosomal DNA binding 4/503 42/18639 0.0952380952380952 3.52911104799773 0.0261375252241956 0.362249763654086 GO:0008237 metallopeptidase activity 10/503 184/18639 0.0543478260869565 2.01389489152044 0.0279937175438909 0.380814281805266 GO:0005522 profilin binding 2/503 10/18639 0.2 7.41113320079523 0.0283356737307188 0.380814281805266 GO:0038024 cargo receptor activity 5/503 65/18639 0.0769230769230769 2.8504358464597 0.0308374666953061 0.396724525753877 GO:0015216 purine nucleotide transmembrane transporter activity 3/503 26/18639 0.115384615384615 4.27565376968955 0.0320576710663257 0.396724525753877 GO:0043548 phosphatidylinositol 3-kinase binding 3/503 26/18639 0.115384615384615 4.27565376968955 0.0320576710663257 0.396724525753877 GO:0070412 R-SMAD binding 3/503 26/18639 0.115384615384615 4.27565376968955 0.0320576710663257 0.396724525753877 GO:0003779 actin binding 19/503 443/18639 0.0428893905191874 1.58929493019311 0.0324987210314923 0.396724525753877 GO:0004143 ATP-dependent diacylglycerol kinase activity 2/503 11/18639 0.181818181818182 6.73739381890475 0.0340231044862379 0.396724525753877 GO:0015217 ADP transmembrane transporter activity 2/503 11/18639 0.181818181818182 6.73739381890475 0.0340231044862379 0.396724525753877 GO:0032050 clathrin heavy chain binding 2/503 11/18639 0.181818181818182 6.73739381890475 0.0340231044862379 0.396724525753877 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 2/503 11/18639 0.181818181818182 6.73739381890475 0.0340231044862379 0.396724525753877 GO:0048185 activin binding 2/503 11/18639 0.181818181818182 6.73739381890475 0.0340231044862379 0.396724525753877 GO:0050840 extracellular matrix binding 5/503 67/18639 0.0746268656716418 2.76534820925195 0.0345346668661993 0.396724525753877 GO:0019210 kinase inhibitor activity 6/503 90/18639 0.0666666666666667 2.47037773359841 0.0348867113966206 0.396724525753877 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 3/503 27/18639 0.111111111111111 4.11729622266402 0.0353624979921723 0.397044755937428 GO:0033218 amide binding 12/503 247/18639 0.048582995951417 1.80027527144823 0.0364644655857413 0.399497425629016 GO:1990841 promoter-specific chromatin binding 5/503 68/18639 0.0735294117647059 2.72468132382178 0.0364817265794254 0.399497425629016 GO:0051959 dynein light intermediate chain binding 3/503 28/18639 0.107142857142857 3.97024992899744 0.0388358263450312 0.40894797065513 GO:0097718 disordered domain specific binding 3/503 28/18639 0.107142857142857 3.97024992899744 0.0388358263450312 0.40894797065513 GO:0004859 phospholipase inhibitor activity 2/503 12/18639 0.166666666666667 6.17594433399602 0.0401110185422732 0.40894797065513 GO:0005247 voltage-gated chloride channel activity 2/503 12/18639 0.166666666666667 6.17594433399602 0.0401110185422732 0.40894797065513 GO:0015132 prostaglandin transmembrane transporter activity 2/503 12/18639 0.166666666666667 6.17594433399602 0.0401110185422732 0.40894797065513 GO:0015166 polyol transmembrane transporter activity 2/503 12/18639 0.166666666666667 6.17594433399602 0.0401110185422732 0.40894797065513 GO:0016758 hexosyltransferase activity 10/503 197/18639 0.050761421319797 1.88099827431351 0.0416307540109462 0.409018975972418 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 3/503 29/18639 0.103448275862069 3.83334475903201 0.0424758419568934 0.409018975972418 GO:0008106 alcohol dehydrogenase (NADP+) activity 3/503 30/18639 0.1 3.70556660039761 0.0462804468073201 0.409018975972418 GO:0015215 nucleotide transmembrane transporter activity 3/503 30/18639 0.1 3.70556660039761 0.0462804468073201 0.409018975972418 GO:0016769 transferase activity, transferring nitrogenous groups 3/503 30/18639 0.1 3.70556660039761 0.0462804468073201 0.409018975972418 GO:0008035 high-density lipoprotein particle binding 2/503 13/18639 0.153846153846154 5.70087169291941 0.0465737503643903 0.409018975972418 GO:0019855 calcium channel inhibitor activity 2/503 13/18639 0.153846153846154 5.70087169291941 0.0465737503643903 0.409018975972418 GO:0043560 insulin receptor substrate binding 2/503 13/18639 0.153846153846154 5.70087169291941 0.0465737503643903 0.409018975972418 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 2/503 13/18639 0.153846153846154 5.70087169291941 0.0465737503643903 0.409018975972418 GO:0045159 myosin II binding 2/503 13/18639 0.153846153846154 5.70087169291941 0.0465737503643903 0.409018975972418 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 2/503 13/18639 0.153846153846154 5.70087169291941 0.0465737503643903 0.409018975972418 GO:0071714 icosanoid transmembrane transporter activity 2/503 13/18639 0.153846153846154 5.70087169291941 0.0465737503643903 0.409018975972418 GO:0140333 glycerophospholipid flippase activity 2/503 13/18639 0.153846153846154 5.70087169291941 0.0465737503643903 0.409018975972418 GO:0140666 annealing activity 2/503 13/18639 0.153846153846154 5.70087169291941 0.0465737503643903 0.409018975972418 GO:0004674 protein serine/threonine kinase activity 18/503 433/18639 0.0415704387990762 1.5404202957773 0.0472391065564057 0.410794975642469 GO:0003712 transcription coregulator activity 20/503 495/18639 0.0404040404040404 1.49719862642328 0.0484408878005504 0.416178153073249 GO:0042626 ATPase-coupled transmembrane transporter activity 6/503 98/18639 0.0612244897959184 2.2687142451414 0.0494605035575627 0.416178153073249 GO:0031491 nucleosome binding 5/503 74/18639 0.0675675675675676 2.50376121648487 0.0495655185218342 0.416178153073249 GO:0070273 phosphatidylinositol-4-phosphate binding 3/503 31/18639 0.0967741935483871 3.58603219393318 0.0502472825110336 0.416178153073249 GO:0019842 vitamin binding 8/503 150/18639 0.0533333333333333 1.97630218687873 0.0508371611121109 0.416178153073249 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 15/503 349/18639 0.0429799426934097 1.59265040131703 0.0524234759274639 0.416178153073249 GO:0005347 ATP transmembrane transporter activity 2/503 14/18639 0.142857142857143 5.29366657199659 0.0533867232051612 0.416178153073249 GO:0005545 1-phosphatidylinositol binding 2/503 14/18639 0.142857142857143 5.29366657199659 0.0533867232051612 0.416178153073249 GO:0042043 neurexin family protein binding 2/503 14/18639 0.142857142857143 5.29366657199659 0.0533867232051612 0.416178153073249 GO:0044548 S100 protein binding 2/503 14/18639 0.142857142857143 5.29366657199659 0.0533867232051612 0.416178153073249 GO:1901612 cardiolipin binding 2/503 14/18639 0.142857142857143 5.29366657199659 0.0533867232051612 0.416178153073249 GO:0051059 NF-kappaB binding 3/503 32/18639 0.09375 3.47396868787276 0.0543737525658268 0.416178153073249 GO:0005246 calcium channel regulator activity 4/503 53/18639 0.0754716981132075 2.79665403803594 0.0544269061516311 0.416178153073249 GO:0016860 intramolecular oxidoreductase activity 4/503 53/18639 0.0754716981132075 2.79665403803594 0.0544269061516311 0.416178153073249 GO:0016853 isomerase activity 9/503 180/18639 0.05 1.85278330019881 0.0557364244914291 0.419915170950587 GO:0003774 cytoskeletal motor activity 8/503 153/18639 0.0522875816993464 1.9375511636066 0.0558624466428063 0.419915170950587 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 4/503 54/18639 0.0740740740740741 2.74486414844268 0.0575822415532264 0.426194725456122 GO:0051015 actin filament binding 10/503 209/18639 0.0478468899521531 1.77299837339599 0.0577304974289778 0.426194725456122 GO:0016757 glycosyltransferase activity 12/503 267/18639 0.0449438202247191 1.66542319118994 0.059202346641676 0.426194725456122 GO:0015250 water channel activity 2/503 15/18639 0.133333333333333 4.94075546719682 0.0605264092215817 0.426194725456122 GO:0015929 hexosaminidase activity 2/503 15/18639 0.133333333333333 4.94075546719682 0.0605264092215817 0.426194725456122 GO:0016846 carbon-sulfur lyase activity 2/503 15/18639 0.133333333333333 4.94075546719682 0.0605264092215817 0.426194725456122 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 2/503 15/18639 0.133333333333333 4.94075546719682 0.0605264092215817 0.426194725456122 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 12/503 268/18639 0.0447761194029851 1.65920892555117 0.0605417535597197 0.426194725456122 GO:0051427 hormone receptor binding 3/503 34/18639 0.0882352941176471 3.26961758858613 0.0630941443779809 0.440070423857983 GO:0030170 pyridoxal phosphate binding 4/503 56/18639 0.0714285714285714 2.6468332859983 0.0641799580656505 0.440070423857983 GO:0048306 calcium-dependent protein binding 5/503 80/18639 0.0625 2.31597912524851 0.0650778857022652 0.440070423857983 GO:0070279 vitamin B6 binding 4/503 57/18639 0.0701754385964912 2.60039761431412 0.067620909681407 0.440070423857983 GO:0001618 virus receptor activity 5/503 81/18639 0.0617283950617284 2.2873867903689 0.0678992150383192 0.440070423857983 GO:0005159 insulin-like growth factor receptor binding 2/503 16/18639 0.125 4.63195825049702 0.0679702909453706 0.440070423857983 GO:0015562 efflux transmembrane transporter activity 2/503 16/18639 0.125 4.63195825049702 0.0679702909453706 0.440070423857983 GO:0016722 oxidoreductase activity, acting on metal ions 2/503 16/18639 0.125 4.63195825049702 0.0679702909453706 0.440070423857983 GO:0031435 mitogen-activated protein kinase kinase kinase binding 2/503 16/18639 0.125 4.63195825049702 0.0679702909453706 0.440070423857983 GO:0055102 lipase inhibitor activity 2/503 16/18639 0.125 4.63195825049702 0.0679702909453706 0.440070423857983 GO:0140327 flippase activity 2/503 16/18639 0.125 4.63195825049702 0.0679702909453706 0.440070423857983 GO:0019888 protein phosphatase regulator activity 6/503 107/18639 0.0560747663551402 2.07788781330707 0.0697470171646007 0.44830147989131 GO:0005178 integrin binding 8/503 161/18639 0.0496894409937888 1.84127532939012 0.0707654850952856 0.448489148097052 GO:0140272 exogenous protein binding 5/503 82/18639 0.0609756097560976 2.25949182951074 0.0707874641866824 0.448489148097052 GO:0004033 aldo-keto reductase (NADPH) activity 3/503 36/18639 0.0833333333333333 3.08797216699801 0.0724168603418366 0.452615555451301 GO:0001540 amyloid-beta binding 5/503 83/18639 0.0602409638554217 2.2322690363841 0.0737423440871166 0.452615555451301 GO:0004879 nuclear receptor activity 4/503 59/18639 0.0677966101694915 2.51224854264245 0.0747827627369857 0.452615555451301 GO:0001217 DNA-binding transcription repressor activity 12/503 278/18639 0.0431654676258993 1.59952515125077 0.0750472104452173 0.452615555451301 GO:0015347 sodium-independent organic anion transmembrane transporter activity 2/503 17/18639 0.117647058823529 4.35949011811484 0.0756968240623981 0.452615555451301 GO:0030169 low-density lipoprotein particle binding 2/503 17/18639 0.117647058823529 4.35949011811484 0.0756968240623981 0.452615555451301 GO:0038191 neuropilin binding 2/503 17/18639 0.117647058823529 4.35949011811484 0.0756968240623981 0.452615555451301 GO:0044325 transmembrane transporter binding 7/503 136/18639 0.0514705882352941 1.90727692667524 0.0757105425035208 0.452615555451301 GO:0051117 ATPase binding 5/503 84/18639 0.0595238095238095 2.20569440499858 0.0767635207395823 0.452615555451301 GO:0030551 cyclic nucleotide binding 3/503 37/18639 0.0810810810810811 3.00451345978185 0.0772956328514205 0.452615555451301 GO:0043394 proteoglycan binding 3/503 37/18639 0.0810810810810811 3.00451345978185 0.0772956328514205 0.452615555451301 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 4/503 60/18639 0.0666666666666667 2.47037773359841 0.0785017192080576 0.452615555451301 GO:0015399 primary active transmembrane transporter activity 8/503 166/18639 0.0481927710843374 1.78581522910728 0.081202075317257 0.452615555451301 GO:0005543 phospholipid binding 19/503 497/18639 0.0382293762575453 1.41661499813993 0.0817946603313203 0.452615555451301 GO:0000146 microfilament motor activity 3/503 38/18639 0.0789473684210526 2.92544731610338 0.0823145631950609 0.452615555451301 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 5/503 86/18639 0.0581395348837209 2.15439918627768 0.0830032095712349 0.452615555451301 GO:0000400 four-way junction DNA binding 2/503 18/18639 0.111111111111111 4.11729622266402 0.0836854014588651 0.452615555451301 GO:0005372 water transmembrane transporter activity 2/503 18/18639 0.111111111111111 4.11729622266402 0.0836854014588651 0.452615555451301 GO:0008308 voltage-gated monoatomic anion channel activity 2/503 18/18639 0.111111111111111 4.11729622266402 0.0836854014588651 0.452615555451301 GO:0008525 phosphatidylcholine transporter activity 2/503 18/18639 0.111111111111111 4.11729622266402 0.0836854014588651 0.452615555451301 GO:0030228 lipoprotein particle receptor activity 2/503 18/18639 0.111111111111111 4.11729622266402 0.0836854014588651 0.452615555451301 GO:0031690 adrenergic receptor binding 2/503 18/18639 0.111111111111111 4.11729622266402 0.0836854014588651 0.452615555451301 GO:0035615 clathrin adaptor activity 2/503 18/18639 0.111111111111111 4.11729622266402 0.0836854014588651 0.452615555451301 GO:1901611 phosphatidylglycerol binding 2/503 18/18639 0.111111111111111 4.11729622266402 0.0836854014588651 0.452615555451301 GO:0005201 extracellular matrix structural constituent 8/503 168/18639 0.0476190476190476 1.76455552399886 0.085619075452615 0.460267393493754 GO:0001221 transcription coregulator binding 6/503 115/18639 0.0521739130434783 1.93333909585962 0.0912638465891731 0.475585119116598 GO:0005229 intracellularly calcium-gated chloride channel activity 2/503 19/18639 0.105263157894737 3.90059642147117 0.0919163184931801 0.475585119116598 GO:0008381 mechanosensitive monoatomic ion channel activity 2/503 19/18639 0.105263157894737 3.90059642147117 0.0919163184931801 0.475585119116598 GO:0043395 heparan sulfate proteoglycan binding 2/503 19/18639 0.105263157894737 3.90059642147117 0.0919163184931801 0.475585119116598 GO:0046624 sphingolipid transporter activity 2/503 19/18639 0.105263157894737 3.90059642147117 0.0919163184931801 0.475585119116598 GO:0141147 intracellularly calcium-gated channel activity 2/503 19/18639 0.105263157894737 3.90059642147117 0.0919163184931801 0.475585119116598 GO:0015144 carbohydrate transmembrane transporter activity 3/503 40/18639 0.075 2.77917495029821 0.0927578642696408 0.475585119116598 GO:0140662 ATP-dependent protein folding chaperone 3/503 40/18639 0.075 2.77917495029821 0.0927578642696408 0.475585119116598 GO:0019955 cytokine binding 7/503 144/18639 0.0486111111111111 1.80131709741551 0.0954852377756279 0.481237004840495 GO:0019208 phosphatase regulator activity 6/503 117/18639 0.0512820512820513 1.90029056430647 0.0971466745645035 0.481237004840495 GO:0008194 UDP-glycosyltransferase activity 7/503 145/18639 0.0482758620689655 1.78889422088161 0.0981409266924399 0.481237004840495 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 3/503 41/18639 0.0731707317073171 2.71139019541289 0.0981744850766975 0.481237004840495 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 5/503 91/18639 0.0549450549450549 2.03602560461407 0.099731044061154 0.481237004840495 GO:0004857 enzyme inhibitor activity 16/503 416/18639 0.0384615384615385 1.42521792322985 0.0997400799059864 0.481237004840495 GO:0022853 active monoatomic ion transmembrane transporter activity 6/503 118/18639 0.0508474576271186 1.88418640698184 0.100162161673549 0.481237004840495 GO:0001614 purinergic nucleotide receptor activity 2/503 20/18639 0.1 3.70556660039761 0.100370739453767 0.481237004840495 GO:0016502 nucleotide receptor activity 2/503 20/18639 0.1 3.70556660039761 0.100370739453767 0.481237004840495 GO:0031418 L-ascorbic acid binding 2/503 20/18639 0.1 3.70556660039761 0.100370739453767 0.481237004840495 GO:0043024 ribosomal small subunit binding 2/503 20/18639 0.1 3.70556660039761 0.100370739453767 0.481237004840495 GO:0052745 inositol phosphate phosphatase activity 2/503 20/18639 0.1 3.70556660039761 0.100370739453767 0.481237004840495 GO:0016887 ATP hydrolysis activity 16/503 417/18639 0.0383693045563549 1.42180013444513 0.101287800851943 0.483023007288567 GO:0008307 structural constituent of muscle 3/503 42/18639 0.0714285714285714 2.6468332859983 0.103715789680736 0.489339922589429 GO:0048487 beta-tubulin binding 3/503 42/18639 0.0714285714285714 2.6468332859983 0.103715789680736 0.489339922589429 GO:0019209 kinase activator activity 7/503 148/18639 0.0472972972972973 1.75263285153941 0.106349188311321 0.499109682709743 GO:0140312 cargo adaptor activity 2/503 21/18639 0.0952380952380952 3.52911104799773 0.109030665164284 0.507947871198623 GO:0004712 protein serine/threonine/tyrosine kinase activity 3/503 43/18639 0.0697674418604651 2.58527902353322 0.109377726492601 0.507947871198623 GO:0016410 N-acyltransferase activity 5/503 94/18639 0.0531914893617021 1.97104606404128 0.110518064361384 0.510570432752854 GO:0008514 organic anion transmembrane transporter activity 11/503 269/18639 0.0408921933085502 1.51528745741166 0.113407371978513 0.521203828730265 GO:0001046 core promoter sequence-specific DNA binding 3/503 44/18639 0.0681818181818182 2.52652268208928 0.115156193888609 0.523813046047159 GO:0043014 alpha-tubulin binding 3/503 44/18639 0.0681818181818182 2.52652268208928 0.115156193888609 0.523813046047159 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 8/503 181/18639 0.0441988950276243 1.63781949188845 0.117664063939405 0.528662820728896 GO:0008970 phospholipase A1 activity 2/503 22/18639 0.0909090909090909 3.36869690945238 0.117878901698945 0.528662820728896 GO:0004896 cytokine receptor activity 5/503 96/18639 0.0520833333333333 1.92998260437376 0.118010415450193 0.528662820728896 GO:0140303 intramembrane lipid transporter activity 3/503 45/18639 0.0666666666666667 2.47037773359841 0.12104705058505 0.539541376225826 GO:0004602 glutathione peroxidase activity 2/503 23/18639 0.0869565217391304 3.22223182643271 0.126899030171801 0.557224949318748 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 2/503 23/18639 0.0869565217391304 3.22223182643271 0.126899030171801 0.557224949318748 GO:0099186 structural constituent of postsynapse 2/503 23/18639 0.0869565217391304 3.22223182643271 0.126899030171801 0.557224949318748 GO:1901981 phosphatidylinositol phosphate binding 8/503 185/18639 0.0432432432432432 1.60240717855032 0.128658485468109 0.562167865074939 GO:0042826 histone deacetylase binding 6/503 127/18639 0.047244094488189 1.75066138601462 0.129454614104494 0.562873738777871 GO:0001784 phosphotyrosine residue binding 3/503 47/18639 0.0638297872340425 2.36525527684954 0.133149226190075 0.570986113318752 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 2/503 24/18639 0.0833333333333333 3.08797216699801 0.136075377564984 0.570986113318752 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 2/503 24/18639 0.0833333333333333 3.08797216699801 0.136075377564984 0.570986113318752 GO:0030215 semaphorin receptor binding 2/503 24/18639 0.0833333333333333 3.08797216699801 0.136075377564984 0.570986113318752 GO:0042625 ATPase-coupled ion transmembrane transporter activity 2/503 24/18639 0.0833333333333333 3.08797216699801 0.136075377564984 0.570986113318752 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 2/503 24/18639 0.0833333333333333 3.08797216699801 0.136075377564984 0.570986113318752 GO:0046961 proton-transporting ATPase activity, rotational mechanism 2/503 24/18639 0.0833333333333333 3.08797216699801 0.136075377564984 0.570986113318752 GO:0035591 signaling adaptor activity 6/503 129/18639 0.0465116279069767 1.72351934902215 0.136470187174268 0.570986113318752 GO:0042277 peptide binding 10/503 249/18639 0.0401606425702811 1.4881793575894 0.137892489717245 0.574228349198106 GO:0035064 methylated histone binding 4/503 74/18639 0.0540540540540541 2.0030089731879 0.139465211742643 0.57776234099246 GO:0016798 hydrolase activity, acting on glycosyl bonds 6/503 130/18639 0.0461538461538462 1.71026150787582 0.140043859428838 0.57776234099246 GO:0000030 mannosyltransferase activity 2/503 25/18639 0.08 2.96445328031809 0.145392988562012 0.586082922166031 GO:0008483 transaminase activity 2/503 25/18639 0.08 2.96445328031809 0.145392988562012 0.586082922166031 GO:0015662 P-type ion transporter activity 2/503 25/18639 0.08 2.96445328031809 0.145392988562012 0.586082922166031 GO:0120020 cholesterol transfer activity 2/503 25/18639 0.08 2.96445328031809 0.145392988562012 0.586082922166031 GO:0140358 P-type transmembrane transporter activity 2/503 25/18639 0.08 2.96445328031809 0.145392988562012 0.586082922166031 GO:0005253 monoatomic anion channel activity 5/503 103/18639 0.0485436893203883 1.79881873805709 0.1460251700098 0.586082922166031 GO:0098631 cell adhesion mediator activity 4/503 76/18639 0.0526315789473684 1.95029821073559 0.149389845507292 0.594209833923624 GO:0140034 methylation-dependent protein binding 4/503 76/18639 0.0526315789473684 1.95029821073559 0.149389845507292 0.594209833923624 GO:0015605 organophosphate ester transmembrane transporter activity 3/503 50/18639 0.06 2.22333996023857 0.152040627290761 0.599742138599975 GO:0004112 cyclic-nucleotide phosphodiesterase activity 2/503 26/18639 0.0769230769230769 2.8504358464597 0.154837598353319 0.599742138599975 GO:0008198 ferrous iron binding 2/503 26/18639 0.0769230769230769 2.8504358464597 0.154837598353319 0.599742138599975 GO:0050681 nuclear androgen receptor binding 2/503 26/18639 0.0769230769230769 2.8504358464597 0.154837598353319 0.599742138599975 GO:0050750 low-density lipoprotein particle receptor binding 2/503 26/18639 0.0769230769230769 2.8504358464597 0.154837598353319 0.599742138599975 GO:0070006 metalloaminopeptidase activity 2/503 26/18639 0.0769230769230769 2.8504358464597 0.154837598353319 0.599742138599975 GO:0005010 insulin-like growth factor receptor activity 3/503 51/18639 0.0588235294117647 2.17974505905742 0.15851778218902 0.609874632749392 GO:0004497 monooxygenase activity 5/503 106/18639 0.0471698113207547 1.74790877377246 0.158828681133156 0.609874632749392 GO:0019199 transmembrane receptor protein kinase activity 4/503 78/18639 0.0512820512820513 1.90029056430647 0.159576441756961 0.610104757924245 GO:0046332 SMAD binding 4/503 79/18639 0.0506329113924051 1.87623625336588 0.164763253618968 0.617622107502593 GO:0005080 protein kinase C binding 3/503 52/18639 0.0576923076923077 2.13782688484478 0.165077969876255 0.617622107502593 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 3/503 52/18639 0.0576923076923077 2.13782688484478 0.165077969876255 0.617622107502593 GO:0004864 protein phosphatase inhibitor activity 3/503 53/18639 0.0566037735849057 2.09749052852695 0.171717033699732 0.617622107502593 GO:0005544 calcium-dependent phospholipid binding 3/503 53/18639 0.0566037735849057 2.09749052852695 0.171717033699732 0.617622107502593 GO:1901505 carbohydrate derivative transmembrane transporter activity 3/503 53/18639 0.0566037735849057 2.09749052852695 0.171717033699732 0.617622107502593 GO:0045499 chemorepellent activity 2/503 28/18639 0.0714285714285714 2.6468332859983 0.174054051000456 0.617622107502593 GO:0046966 nuclear thyroid hormone receptor binding 2/503 28/18639 0.0714285714285714 2.6468332859983 0.174054051000456 0.617622107502593 GO:0030295 protein kinase activator activity 6/503 139/18639 0.0431654676258993 1.59952515125077 0.174073203617658 0.617622107502593 GO:0140463 chromatin-protein adaptor activity 3/503 54/18639 0.0555555555555556 2.05864811133201 0.178430845002468 0.617622107502593 GO:1902936 phosphatidylinositol bisphosphate binding 5/503 111/18639 0.045045045045045 1.66917414432325 0.181128248859268 0.617622107502593 GO:0035250 UDP-galactosyltransferase activity 2/503 29/18639 0.0689655172413793 2.55556317268801 0.183800585003682 0.617622107502593 GO:0098632 cell-cell adhesion mediator activity 3/503 55/18639 0.0545454545454545 2.02121814567143 0.185215308258753 0.617622107502593 GO:0140313 molecular sequestering activity 3/503 55/18639 0.0545454545454545 2.02121814567143 0.185215308258753 0.617622107502593 GO:0005200 structural constituent of cytoskeleton 5/503 112/18639 0.0446428571428571 1.65427080374894 0.185722351975446 0.617622107502593 GO:0005254 chloride channel activity 4/503 83/18639 0.0481927710843374 1.78581522910728 0.186088945215686 0.617622107502593 GO:0030165 PDZ domain binding 4/503 83/18639 0.0481927710843374 1.78581522910728 0.186088945215686 0.617622107502593 GO:0020037 heme binding 6/503 142/18639 0.0422535211267606 1.56573236636519 0.186110808848122 0.617622107502593 GO:0019212 phosphatase inhibitor activity 3/503 56/18639 0.0535714285714286 1.98512496449872 0.192066365816853 0.617622107502593 GO:0001965 G-protein alpha-subunit binding 2/503 30/18639 0.0666666666666667 2.47037773359841 0.193623452017708 0.617622107502593 GO:0001968 fibronectin binding 2/503 30/18639 0.0666666666666667 2.47037773359841 0.193623452017708 0.617622107502593 GO:0098918 structural constituent of synapse 2/503 30/18639 0.0666666666666667 2.47037773359841 0.193623452017708 0.617622107502593 GO:0015932 nucleobase-containing compound transmembrane transporter activity 3/503 57/18639 0.0526315789473684 1.95029821073559 0.198980002268822 0.617622107502593 GO:0008327 methyl-CpG binding 2/503 31/18639 0.0645161290322581 2.39068812928878 0.203511463707823 0.617622107502593 GO:0016878 acid-thiol ligase activity 2/503 31/18639 0.0645161290322581 2.39068812928878 0.203511463707823 0.617622107502593 GO:0047499 calcium-independent phospholipase A2 activity 2/503 31/18639 0.0645161290322581 2.39068812928878 0.203511463707823 0.617622107502593 GO:0070325 lipoprotein particle receptor binding 2/503 31/18639 0.0645161290322581 2.39068812928878 0.203511463707823 0.617622107502593 GO:0009055 electron transfer activity 5/503 116/18639 0.0431034482758621 1.59722698293001 0.204508076585894 0.617622107502593 GO:0004175 endopeptidase activity 14/503 405/18639 0.0345679012345679 1.28093660260658 0.207487461805459 0.617622107502593 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 9/503 243/18639 0.037037037037037 1.37243207422134 0.211759282865917 0.617622107502593 GO:0045309 protein phosphorylated amino acid binding 3/503 59/18639 0.0508474576271186 1.88418640698184 0.212979185202018 0.617622107502593 GO:0070888 E-box binding 3/503 59/18639 0.0508474576271186 1.88418640698184 0.212979185202018 0.617622107502593 GO:0008378 galactosyltransferase activity 2/503 32/18639 0.0625 2.31597912524851 0.213453977783957 0.617622107502593 GO:0015106 bicarbonate transmembrane transporter activity 2/503 32/18639 0.0625 2.31597912524851 0.213453977783957 0.617622107502593 GO:0043425 bHLH transcription factor binding 2/503 32/18639 0.0625 2.31597912524851 0.213453977783957 0.617622107502593 GO:0047498 calcium-dependent phospholipase A2 activity 2/503 32/18639 0.0625 2.31597912524851 0.213453977783957 0.617622107502593 GO:0120015 sterol transfer activity 2/503 32/18639 0.0625 2.31597912524851 0.213453977783957 0.617622107502593 GO:0008509 monoatomic anion transmembrane transporter activity 6/503 149/18639 0.0402684563758389 1.49217446995877 0.215387832946781 0.617622107502593 GO:0004676 3-phosphoinositide-dependent protein kinase activity 9/503 245/18639 0.036734693877551 1.36122854708484 0.218375915638559 0.617622107502593 GO:0004711 ribosomal protein S6 kinase activity 9/503 245/18639 0.036734693877551 1.36122854708484 0.218375915638559 0.617622107502593 GO:0035175 histone H3S10 kinase activity 9/503 245/18639 0.036734693877551 1.36122854708484 0.218375915638559 0.617622107502593 GO:0035979 histone H2AXS139 kinase activity 9/503 245/18639 0.036734693877551 1.36122854708484 0.218375915638559 0.617622107502593 GO:0044022 histone H3S28 kinase activity 9/503 245/18639 0.036734693877551 1.36122854708484 0.218375915638559 0.617622107502593 GO:0044023 histone H4S1 kinase activity 9/503 245/18639 0.036734693877551 1.36122854708484 0.218375915638559 0.617622107502593 GO:0044024 histone H2AS1 kinase activity 9/503 245/18639 0.036734693877551 1.36122854708484 0.218375915638559 0.617622107502593 GO:0044025 histone H2BS14 kinase activity 9/503 245/18639 0.036734693877551 1.36122854708484 0.218375915638559 0.617622107502593 GO:0072354 histone H3T3 kinase activity 9/503 245/18639 0.036734693877551 1.36122854708484 0.218375915638559 0.617622107502593 GO:0072371 histone H2AS121 kinase activity 9/503 245/18639 0.036734693877551 1.36122854708484 0.218375915638559 0.617622107502593 GO:0072518 Rho-dependent protein serine/threonine kinase activity 9/503 245/18639 0.036734693877551 1.36122854708484 0.218375915638559 0.617622107502593 GO:0140823 histone H2BS36 kinase activity 9/503 245/18639 0.036734693877551 1.36122854708484 0.218375915638559 0.617622107502593 GO:0140855 histone H3S57 kinase activity 9/503 245/18639 0.036734693877551 1.36122854708484 0.218375915638559 0.617622107502593 GO:0140995 histone H2A kinase activity 9/503 245/18639 0.036734693877551 1.36122854708484 0.218375915638559 0.617622107502593 GO:0140997 histone H4 kinase activity 9/503 245/18639 0.036734693877551 1.36122854708484 0.218375915638559 0.617622107502593 GO:0140998 histone H2B kinase activity 9/503 245/18639 0.036734693877551 1.36122854708484 0.218375915638559 0.617622107502593 GO:1990244 histone H2AT120 kinase activity 9/503 245/18639 0.036734693877551 1.36122854708484 0.218375915638559 0.617622107502593 GO:0004714 transmembrane receptor protein tyrosine kinase activity 3/503 60/18639 0.05 1.85278330019881 0.220056946570121 0.617622107502593 GO:0004677 DNA-dependent protein kinase activity 9/503 246/18639 0.0365853658536585 1.35569509770644 0.221714230191721 0.617622107502593 GO:0140857 histone H3T45 kinase activity 9/503 246/18639 0.0365853658536585 1.35569509770644 0.221714230191721 0.617622107502593 GO:0071889 14-3-3 protein binding 2/503 33/18639 0.0606060606060606 2.24579793963492 0.223440876775489 0.617622107502593 GO:0035402 histone H3T11 kinase activity 9/503 247/18639 0.0364372469635627 1.35020645358618 0.225072082598581 0.617622107502593 GO:0035403 histone H3T6 kinase activity 9/503 247/18639 0.0364372469635627 1.35020645358618 0.225072082598581 0.617622107502593 GO:0042393 histone binding 9/503 247/18639 0.0364372469635627 1.35020645358618 0.225072082598581 0.617622107502593 GO:0030246 carbohydrate binding 10/503 280/18639 0.0357142857142857 1.32341664299915 0.226450152524015 0.617622107502593 GO:0015026 coreceptor activity 3/503 61/18639 0.0491803278688525 1.82240980347424 0.227181723029302 0.617622107502593 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 3/503 61/18639 0.0491803278688525 1.82240980347424 0.227181723029302 0.617622107502593 GO:0046906 tetrapyrrole binding 6/503 152/18639 0.0394736842105263 1.46272365805169 0.228394228069882 0.617622107502593 GO:0004679 AMP-activated protein kinase activity 9/503 248/18639 0.0362903225806452 1.34476207272494 0.228449122567606 0.617622107502593 GO:0015108 chloride transmembrane transporter activity 5/503 121/18639 0.0413223140495868 1.5312258679329 0.228823049500297 0.617622107502593 GO:0015020 glucuronosyltransferase activity 2/503 34/18639 0.0588235294117647 2.17974505905742 0.233462547550334 0.617622107502593 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 2/503 34/18639 0.0588235294117647 2.17974505905742 0.233462547550334 0.617622107502593 GO:0016831 carboxy-lyase activity 2/503 34/18639 0.0588235294117647 2.17974505905742 0.233462547550334 0.617622107502593 GO:0035091 phosphatidylinositol binding 10/503 284/18639 0.0352112676056338 1.30477697197099 0.239247082430409 0.617622107502593 GO:0001094 TFIID-class transcription factor complex binding 1/503 10/18639 0.1 3.70556660039761 0.239393736568499 0.617622107502593 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 1/503 10/18639 0.1 3.70556660039761 0.239393736568499 0.617622107502593 GO:0004090 carbonyl reductase (NADPH) activity 1/503 10/18639 0.1 3.70556660039761 0.239393736568499 0.617622107502593 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 1/503 10/18639 0.1 3.70556660039761 0.239393736568499 0.617622107502593 GO:0004445 inositol-polyphosphate 5-phosphatase activity 1/503 10/18639 0.1 3.70556660039761 0.239393736568499 0.617622107502593 GO:0004862 cAMP-dependent protein kinase inhibitor activity 1/503 10/18639 0.1 3.70556660039761 0.239393736568499 0.617622107502593 GO:0005031 tumor necrosis factor receptor activity 1/503 10/18639 0.1 3.70556660039761 0.239393736568499 0.617622107502593 GO:0005345 purine nucleobase transmembrane transporter activity 1/503 10/18639 0.1 3.70556660039761 0.239393736568499 0.617622107502593 GO:0005381 iron ion transmembrane transporter activity 1/503 10/18639 0.1 3.70556660039761 0.239393736568499 0.617622107502593 GO:0005528 FK506 binding 1/503 10/18639 0.1 3.70556660039761 0.239393736568499 0.617622107502593 GO:0015924 mannosyl-oligosaccharide mannosidase activity 1/503 10/18639 0.1 3.70556660039761 0.239393736568499 0.617622107502593 GO:0016303 1-phosphatidylinositol-3-kinase activity 1/503 10/18639 0.1 3.70556660039761 0.239393736568499 0.617622107502593 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1/503 10/18639 0.1 3.70556660039761 0.239393736568499 0.617622107502593 GO:0016868 intramolecular phosphotransferase activity 1/503 10/18639 0.1 3.70556660039761 0.239393736568499 0.617622107502593 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 1/503 10/18639 0.1 3.70556660039761 0.239393736568499 0.617622107502593 GO:0019531 oxalate transmembrane transporter activity 1/503 10/18639 0.1 3.70556660039761 0.239393736568499 0.617622107502593 GO:0030957 Tat protein binding 1/503 10/18639 0.1 3.70556660039761 0.239393736568499 0.617622107502593 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 1/503 10/18639 0.1 3.70556660039761 0.239393736568499 0.617622107502593 GO:0031434 mitogen-activated protein kinase kinase binding 1/503 10/18639 0.1 3.70556660039761 0.239393736568499 0.617622107502593 GO:0031956 medium-chain fatty acid-CoA ligase activity 1/503 10/18639 0.1 3.70556660039761 0.239393736568499 0.617622107502593 GO:0031996 thioesterase binding 1/503 10/18639 0.1 3.70556660039761 0.239393736568499 0.617622107502593 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 1/503 10/18639 0.1 3.70556660039761 0.239393736568499 0.617622107502593 GO:0042975 peroxisome proliferator activated receptor binding 1/503 10/18639 0.1 3.70556660039761 0.239393736568499 0.617622107502593 GO:0045322 unmethylated CpG binding 1/503 10/18639 0.1 3.70556660039761 0.239393736568499 0.617622107502593 GO:0050308 sugar-phosphatase activity 1/503 10/18639 0.1 3.70556660039761 0.239393736568499 0.617622107502593 GO:0140135 mechanosensitive monoatomic cation channel activity 1/503 10/18639 0.1 3.70556660039761 0.239393736568499 0.617622107502593 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 1/503 10/18639 0.1 3.70556660039761 0.239393736568499 0.617622107502593 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 1/503 10/18639 0.1 3.70556660039761 0.239393736568499 0.617622107502593 GO:1905394 retromer complex binding 1/503 10/18639 0.1 3.70556660039761 0.239393736568499 0.617622107502593 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 1/503 10/18639 0.1 3.70556660039761 0.239393736568499 0.617622107502593 GO:1990763 arrestin family protein binding 1/503 10/18639 0.1 3.70556660039761 0.239393736568499 0.617622107502593 GO:0004623 phospholipase A2 activity 2/503 35/18639 0.0571428571428571 2.11746662879864 0.24350986155368 0.617622107502593 GO:0042562 hormone binding 4/503 94/18639 0.0425531914893617 1.57683685123303 0.248642653452901 0.617622107502593 GO:0141003 histone H2AX kinase activity 12/503 354/18639 0.0338983050847458 1.25612427132123 0.250017472850852 0.617622107502593 GO:0016409 palmitoyltransferase activity 2/503 36/18639 0.0555555555555556 2.05864811133201 0.253574155742612 0.617622107502593 GO:0003713 transcription coactivator activity 9/503 256/18639 0.03515625 1.30273825795229 0.256113067851778 0.617622107502593 GO:0140996 histone H3 kinase activity 12/503 357/18639 0.0336134453781513 1.24556860517567 0.258925313997169 0.617622107502593 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 1/503 11/18639 0.0909090909090909 3.36869690945238 0.259930799776726 0.617622107502593 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 1/503 11/18639 0.0909090909090909 3.36869690945238 0.259930799776726 0.617622107502593 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 1/503 11/18639 0.0909090909090909 3.36869690945238 0.259930799776726 0.617622107502593 GO:0002162 dystroglycan binding 1/503 11/18639 0.0909090909090909 3.36869690945238 0.259930799776726 0.617622107502593 GO:0005114 type II transforming growth factor beta receptor binding 1/503 11/18639 0.0909090909090909 3.36869690945238 0.259930799776726 0.617622107502593 GO:0005225 volume-sensitive anion channel activity 1/503 11/18639 0.0909090909090909 3.36869690945238 0.259930799776726 0.617622107502593 GO:0005536 D-glucose binding 1/503 11/18639 0.0909090909090909 3.36869690945238 0.259930799776726 0.617622107502593 GO:0008046 axon guidance receptor activity 1/503 11/18639 0.0909090909090909 3.36869690945238 0.259930799776726 0.617622107502593 GO:0008271 secondary active sulfate transmembrane transporter activity 1/503 11/18639 0.0909090909090909 3.36869690945238 0.259930799776726 0.617622107502593 GO:0008432 JUN kinase binding 1/503 11/18639 0.0909090909090909 3.36869690945238 0.259930799776726 0.617622107502593 GO:0010854 adenylate cyclase regulator activity 1/503 11/18639 0.0909090909090909 3.36869690945238 0.259930799776726 0.617622107502593 GO:0015205 nucleobase transmembrane transporter activity 1/503 11/18639 0.0909090909090909 3.36869690945238 0.259930799776726 0.617622107502593 GO:0016176 superoxide-generating NADPH oxidase activator activity 1/503 11/18639 0.0909090909090909 3.36869690945238 0.259930799776726 0.617622107502593 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 1/503 11/18639 0.0909090909090909 3.36869690945238 0.259930799776726 0.617622107502593 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 1/503 11/18639 0.0909090909090909 3.36869690945238 0.259930799776726 0.617622107502593 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 1/503 11/18639 0.0909090909090909 3.36869690945238 0.259930799776726 0.617622107502593 GO:0019107 myristoyltransferase activity 1/503 11/18639 0.0909090909090909 3.36869690945238 0.259930799776726 0.617622107502593 GO:0019203 carbohydrate phosphatase activity 1/503 11/18639 0.0909090909090909 3.36869690945238 0.259930799776726 0.617622107502593 GO:0019206 nucleoside kinase activity 1/503 11/18639 0.0909090909090909 3.36869690945238 0.259930799776726 0.617622107502593 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 1/503 11/18639 0.0909090909090909 3.36869690945238 0.259930799776726 0.617622107502593 GO:0034056 estrogen response element binding 1/503 11/18639 0.0909090909090909 3.36869690945238 0.259930799776726 0.617622107502593 GO:0034713 type I transforming growth factor beta receptor binding 1/503 11/18639 0.0909090909090909 3.36869690945238 0.259930799776726 0.617622107502593 GO:0035252 UDP-xylosyltransferase activity 1/503 11/18639 0.0909090909090909 3.36869690945238 0.259930799776726 0.617622107502593 GO:0042285 xylosyltransferase activity 1/503 11/18639 0.0909090909090909 3.36869690945238 0.259930799776726 0.617622107502593 GO:0042608 T cell receptor binding 1/503 11/18639 0.0909090909090909 3.36869690945238 0.259930799776726 0.617622107502593 GO:0050998 nitric-oxide synthase binding 1/503 11/18639 0.0909090909090909 3.36869690945238 0.259930799776726 0.617622107502593 GO:0070697 activin receptor binding 1/503 11/18639 0.0909090909090909 3.36869690945238 0.259930799776726 0.617622107502593 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 1/503 11/18639 0.0909090909090909 3.36869690945238 0.259930799776726 0.617622107502593 GO:0099528 G protein-coupled neurotransmitter receptor activity 1/503 11/18639 0.0909090909090909 3.36869690945238 0.259930799776726 0.617622107502593 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 1/503 11/18639 0.0909090909090909 3.36869690945238 0.259930799776726 0.617622107502593 GO:0180030 inositol phosphate kinase activity 1/503 11/18639 0.0909090909090909 3.36869690945238 0.259930799776726 0.617622107502593 GO:0008235 metalloexopeptidase activity 3/503 66/18639 0.0454545454545455 1.68434845472619 0.26338177077102 0.617622107502593 GO:0030280 structural constituent of skin epidermis 2/503 37/18639 0.0540540540540541 2.0030089731879 0.263647214193538 0.617622107502593 GO:0035173 histone kinase activity 12/503 360/18639 0.0333333333333333 1.2351888667992 0.267942663452262 0.617622107502593 GO:0016500 protein-hormone receptor activity 3/503 67/18639 0.0447761194029851 1.65920892555117 0.270712110687209 0.617622107502593 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 3/503 67/18639 0.0447761194029851 1.65920892555117 0.270712110687209 0.617622107502593 GO:0003777 microtubule motor activity 3/503 68/18639 0.0441176470588235 1.63480879429307 0.278064578006647 0.617622107502593 GO:0005548 phospholipid transporter activity 3/503 68/18639 0.0441176470588235 1.63480879429307 0.278064578006647 0.617622107502593 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 8/503 229/18639 0.0349344978165939 1.29452108310834 0.278777023065873 0.617622107502593 GO:0004032 aldose reductase (NADPH) activity 1/503 12/18639 0.0833333333333333 3.08797216699801 0.279914416252585 0.617622107502593 GO:0005025 transforming growth factor beta receptor activity, type I 1/503 12/18639 0.0833333333333333 3.08797216699801 0.279914416252585 0.617622107502593 GO:0005026 transforming growth factor beta receptor activity, type II 1/503 12/18639 0.0833333333333333 3.08797216699801 0.279914416252585 0.617622107502593 GO:0005049 nuclear export signal receptor activity 1/503 12/18639 0.0833333333333333 3.08797216699801 0.279914416252585 0.617622107502593 GO:0005165 neurotrophin receptor binding 1/503 12/18639 0.0833333333333333 3.08797216699801 0.279914416252585 0.617622107502593 GO:0005527 macrolide binding 1/503 12/18639 0.0833333333333333 3.08797216699801 0.279914416252585 0.617622107502593 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 1/503 12/18639 0.0833333333333333 3.08797216699801 0.279914416252585 0.617622107502593 GO:0008603 cAMP-dependent protein kinase regulator activity 1/503 12/18639 0.0833333333333333 3.08797216699801 0.279914416252585 0.617622107502593 GO:0010853 cyclase activator activity 1/503 12/18639 0.0833333333333333 3.08797216699801 0.279914416252585 0.617622107502593 GO:0016361 activin receptor activity, type I 1/503 12/18639 0.0833333333333333 3.08797216699801 0.279914416252585 0.617622107502593 GO:0016362 activin receptor activity, type II 1/503 12/18639 0.0833333333333333 3.08797216699801 0.279914416252585 0.617622107502593 GO:0016840 carbon-nitrogen lyase activity 1/503 12/18639 0.0833333333333333 3.08797216699801 0.279914416252585 0.617622107502593 GO:0017002 activin receptor activity 1/503 12/18639 0.0833333333333333 3.08797216699801 0.279914416252585 0.617622107502593 GO:0017166 vinculin binding 1/503 12/18639 0.0833333333333333 3.08797216699801 0.279914416252585 0.617622107502593 GO:0031543 peptidyl-proline dioxygenase activity 1/503 12/18639 0.0833333333333333 3.08797216699801 0.279914416252585 0.617622107502593 GO:0035014 phosphatidylinositol 3-kinase regulator activity 1/503 12/18639 0.0833333333333333 3.08797216699801 0.279914416252585 0.617622107502593 GO:0035251 UDP-glucosyltransferase activity 1/503 12/18639 0.0833333333333333 3.08797216699801 0.279914416252585 0.617622107502593 GO:0035259 nuclear glucocorticoid receptor binding 1/503 12/18639 0.0833333333333333 3.08797216699801 0.279914416252585 0.617622107502593 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 1/503 12/18639 0.0833333333333333 3.08797216699801 0.279914416252585 0.617622107502593 GO:0140829 bicarbonate:monoatomic anion antiporter activity 1/503 12/18639 0.0833333333333333 3.08797216699801 0.279914416252585 0.617622107502593 GO:0140900 chloride:bicarbonate antiporter activity 1/503 12/18639 0.0833333333333333 3.08797216699801 0.279914416252585 0.617622107502593 GO:0141221 histone deacetylase activity, hydrolytic mechanism 1/503 12/18639 0.0833333333333333 3.08797216699801 0.279914416252585 0.617622107502593 GO:0000287 magnesium ion binding 8/503 230/18639 0.0347826086956522 1.28889273057308 0.282665508351851 0.622144679672685 GO:0000217 DNA secondary structure binding 2/503 39/18639 0.0512820512820513 1.90029056430647 0.283788889960105 0.623071151966865 GO:0004177 aminopeptidase activity 2/503 40/18639 0.05 1.85278330019881 0.293843154470129 0.626254366594996 GO:0015036 disulfide oxidoreductase activity 2/503 40/18639 0.05 1.85278330019881 0.293843154470129 0.626254366594996 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 2/503 40/18639 0.05 1.85278330019881 0.293843154470129 0.626254366594996 GO:0050997 quaternary ammonium group binding 2/503 40/18639 0.05 1.85278330019881 0.293843154470129 0.626254366594996 GO:0061791 GTPase motor activity 2/503 40/18639 0.05 1.85278330019881 0.293843154470129 0.626254366594996 GO:1990606 membrane scission GTPase motor activity 2/503 40/18639 0.05 1.85278330019881 0.293843154470129 0.626254366594996 GO:0051087 protein-folding chaperone binding 5/503 134/18639 0.0373134328358209 1.38267410462598 0.295344079014406 0.626254366594996 GO:0016829 lyase activity 7/503 200/18639 0.035 1.29694831013917 0.296068183228658 0.626254366594996 GO:0008238 exopeptidase activity 4/503 102/18639 0.0392156862745098 1.45316337270495 0.296599672340429 0.626254366594996 GO:0004465 lipoprotein lipase activity 1/503 13/18639 0.0769230769230769 2.8504358464597 0.299359471743268 0.626254366594996 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 1/503 13/18639 0.0769230769230769 2.8504358464597 0.299359471743268 0.626254366594996 GO:0005035 death receptor activity 1/503 13/18639 0.0769230769230769 2.8504358464597 0.299359471743268 0.626254366594996 GO:0005542 folic acid binding 1/503 13/18639 0.0769230769230769 2.8504358464597 0.299359471743268 0.626254366594996 GO:0008417 fucosyltransferase activity 1/503 13/18639 0.0769230769230769 2.8504358464597 0.299359471743268 0.626254366594996 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 1/503 13/18639 0.0769230769230769 2.8504358464597 0.299359471743268 0.626254366594996 GO:0019104 DNA N-glycosylase activity 1/503 13/18639 0.0769230769230769 2.8504358464597 0.299359471743268 0.626254366594996 GO:0031432 titin binding 1/503 13/18639 0.0769230769230769 2.8504358464597 0.299359471743268 0.626254366594996 GO:0070123 transforming growth factor beta receptor activity, type III 1/503 13/18639 0.0769230769230769 2.8504358464597 0.299359471743268 0.626254366594996 GO:0071837 HMG box domain binding 1/503 13/18639 0.0769230769230769 2.8504358464597 0.299359471743268 0.626254366594996 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 1/503 13/18639 0.0769230769230769 2.8504358464597 0.299359471743268 0.626254366594996 GO:0016877 ligase activity, forming carbon-sulfur bonds 2/503 41/18639 0.0487804878048781 1.80759346360859 0.303877445208254 0.632721347182444 GO:0017080 sodium channel regulator activity 2/503 41/18639 0.0487804878048781 1.80759346360859 0.303877445208254 0.632721347182444 GO:0005518 collagen binding 3/503 72/18639 0.0416666666666667 1.54398608349901 0.307631225072622 0.639037228663738 GO:0016859 cis-trans isomerase activity 2/503 42/18639 0.0476190476190476 1.76455552399886 0.31388552798463 0.640169526709387 GO:0035198 miRNA binding 2/503 42/18639 0.0476190476190476 1.76455552399886 0.31388552798463 0.640169526709387 GO:0004065 arylsulfatase activity 1/503 14/18639 0.0714285714285714 2.6468332859983 0.318280452400045 0.640169526709387 GO:0008191 metalloendopeptidase inhibitor activity 1/503 14/18639 0.0714285714285714 2.6468332859983 0.318280452400045 0.640169526709387 GO:0008494 translation activator activity 1/503 14/18639 0.0714285714285714 2.6468332859983 0.318280452400045 0.640169526709387 GO:0008559 ABC-type xenobiotic transporter activity 1/503 14/18639 0.0714285714285714 2.6468332859983 0.318280452400045 0.640169526709387 GO:0031404 chloride ion binding 1/503 14/18639 0.0714285714285714 2.6468332859983 0.318280452400045 0.640169526709387 GO:0032036 myosin heavy chain binding 1/503 14/18639 0.0714285714285714 2.6468332859983 0.318280452400045 0.640169526709387 GO:0034236 protein kinase A catalytic subunit binding 1/503 14/18639 0.0714285714285714 2.6468332859983 0.318280452400045 0.640169526709387 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 1/503 14/18639 0.0714285714285714 2.6468332859983 0.318280452400045 0.640169526709387 GO:0043176 amine binding 1/503 14/18639 0.0714285714285714 2.6468332859983 0.318280452400045 0.640169526709387 GO:0046030 inositol trisphosphate phosphatase activity 1/503 14/18639 0.0714285714285714 2.6468332859983 0.318280452400045 0.640169526709387 GO:0071933 Arp2/3 complex binding 1/503 14/18639 0.0714285714285714 2.6468332859983 0.318280452400045 0.640169526709387 GO:0098821 BMP receptor activity 1/503 14/18639 0.0714285714285714 2.6468332859983 0.318280452400045 0.640169526709387 GO:0140767 enzyme-substrate adaptor activity 5/503 139/18639 0.0359712230215827 1.33293762604231 0.321786966534917 0.645022291608 GO:0008200 ion channel inhibitor activity 2/503 43/18639 0.0465116279069767 1.72351934902215 0.323861518301314 0.645022291608 GO:0001223 transcription coactivator binding 2/503 44/18639 0.0454545454545455 1.68434845472619 0.333799867082871 0.645022291608 GO:0016248 channel inhibitor activity 2/503 44/18639 0.0454545454545455 1.68434845472619 0.333799867082871 0.645022291608 GO:0019205 nucleobase-containing compound kinase activity 2/503 44/18639 0.0454545454545455 1.68434845472619 0.333799867082871 0.645022291608 GO:0004467 long-chain fatty acid-CoA ligase activity 1/503 15/18639 0.0666666666666667 2.47037773359841 0.336691455484221 0.645022291608 GO:0004559 alpha-mannosidase activity 1/503 15/18639 0.0666666666666667 2.47037773359841 0.336691455484221 0.645022291608 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 1/503 15/18639 0.0666666666666667 2.47037773359841 0.336691455484221 0.645022291608 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 1/503 15/18639 0.0666666666666667 2.47037773359841 0.336691455484221 0.645022291608 GO:0005041 low-density lipoprotein particle receptor activity 1/503 15/18639 0.0666666666666667 2.47037773359841 0.336691455484221 0.645022291608 GO:0005523 tropomyosin binding 1/503 15/18639 0.0666666666666667 2.47037773359841 0.336691455484221 0.645022291608 GO:0015116 sulfate transmembrane transporter activity 1/503 15/18639 0.0666666666666667 2.47037773359841 0.336691455484221 0.645022291608 GO:0017081 chloride channel regulator activity 1/503 15/18639 0.0666666666666667 2.47037773359841 0.336691455484221 0.645022291608 GO:0030553 cGMP binding 1/503 15/18639 0.0666666666666667 2.47037773359841 0.336691455484221 0.645022291608 GO:0031005 filamin binding 1/503 15/18639 0.0666666666666667 2.47037773359841 0.336691455484221 0.645022291608 GO:0031386 protein tag activity 1/503 15/18639 0.0666666666666667 2.47037773359841 0.336691455484221 0.645022291608 GO:0047372 monoacylglycerol lipase activity 1/503 15/18639 0.0666666666666667 2.47037773359841 0.336691455484221 0.645022291608 GO:0048531 beta-1,3-galactosyltransferase activity 1/503 15/18639 0.0666666666666667 2.47037773359841 0.336691455484221 0.645022291608 GO:0140161 monocarboxylate:sodium symporter activity 1/503 15/18639 0.0666666666666667 2.47037773359841 0.336691455484221 0.645022291608 GO:0141047 molecular tag activity 1/503 15/18639 0.0666666666666667 2.47037773359841 0.336691455484221 0.645022291608 GO:0141050 histone H3K deacetylase activity 1/503 15/18639 0.0666666666666667 2.47037773359841 0.336691455484221 0.645022291608 GO:0141051 histone H4K deacetylase activity 1/503 15/18639 0.0666666666666667 2.47037773359841 0.336691455484221 0.645022291608 GO:0046915 transition metal ion transmembrane transporter activity 2/503 45/18639 0.0444444444444444 1.64691848906561 0.343695346919979 0.655282706689378 GO:0141110 transporter inhibitor activity 2/503 45/18639 0.0444444444444444 1.64691848906561 0.343695346919979 0.655282706689378 GO:0051020 GTPase binding 10/503 315/18639 0.0317460317460317 1.17637034933258 0.345623393102297 0.655282706689378 GO:0019903 protein phosphatase binding 5/503 144/18639 0.0347222222222222 1.2866550695825 0.348484485940882 0.655282706689378 GO:0005319 lipid transporter activity 6/503 178/18639 0.0337078651685393 1.24906739339245 0.348944150851964 0.655282706689378 GO:0022804 active transmembrane transporter activity 14/503 457/18639 0.0306345733041575 1.13518451653319 0.35207763870641 0.655282706689378 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 2/503 46/18639 0.0434782608695652 1.61111591321635 0.35354303880883 0.655282706689378 GO:0030276 clathrin binding 2/503 46/18639 0.0434782608695652 1.61111591321635 0.35354303880883 0.655282706689378 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 1/503 16/18639 0.0625 2.31597912524851 0.354606199786811 0.655282706689378 GO:0004708 MAP kinase kinase activity 1/503 16/18639 0.0625 2.31597912524851 0.354606199786811 0.655282706689378 GO:0005024 transforming growth factor beta receptor activity 1/503 16/18639 0.0625 2.31597912524851 0.354606199786811 0.655282706689378 GO:0005521 lamin binding 1/503 16/18639 0.0625 2.31597912524851 0.354606199786811 0.655282706689378 GO:0008296 3'-5'-DNA exonuclease activity 1/503 16/18639 0.0625 2.31597912524851 0.354606199786811 0.655282706689378 GO:0015378 sodium:chloride symporter activity 1/503 16/18639 0.0625 2.31597912524851 0.354606199786811 0.655282706689378 GO:0015923 mannosidase activity 1/503 16/18639 0.0625 2.31597912524851 0.354606199786811 0.655282706689378 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 1/503 16/18639 0.0625 2.31597912524851 0.354606199786811 0.655282706689378 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 1/503 16/18639 0.0625 2.31597912524851 0.354606199786811 0.655282706689378 GO:0031267 small GTPase binding 9/503 283/18639 0.0318021201413428 1.17844874217592 0.355823640267397 0.656165423944243 GO:0043495 protein-membrane adaptor activity 2/503 47/18639 0.0425531914893617 1.57683685123303 0.363338319369663 0.664179570561102 GO:0099095 ligand-gated monoatomic anion channel activity 2/503 47/18639 0.0425531914893617 1.57683685123303 0.363338319369663 0.664179570561102 GO:0140359 ABC-type transporter activity 2/503 47/18639 0.0425531914893617 1.57683685123303 0.363338319369663 0.664179570561102 GO:0004659 prenyltransferase activity 1/503 17/18639 0.0588235294117647 2.17974505905742 0.372038035769587 0.664179570561102 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 1/503 17/18639 0.0588235294117647 2.17974505905742 0.372038035769587 0.664179570561102 GO:0008484 sulfuric ester hydrolase activity 1/503 17/18639 0.0588235294117647 2.17974505905742 0.372038035769587 0.664179570561102 GO:0008569 minus-end-directed microtubule motor activity 1/503 17/18639 0.0588235294117647 2.17974505905742 0.372038035769587 0.664179570561102 GO:0019198 transmembrane receptor protein phosphatase activity 1/503 17/18639 0.0588235294117647 2.17974505905742 0.372038035769587 0.664179570561102 GO:0031489 myosin V binding 1/503 17/18639 0.0588235294117647 2.17974505905742 0.372038035769587 0.664179570561102 GO:0046965 nuclear retinoid X receptor binding 1/503 17/18639 0.0588235294117647 2.17974505905742 0.372038035769587 0.664179570561102 GO:0051787 misfolded protein binding 1/503 17/18639 0.0588235294117647 2.17974505905742 0.372038035769587 0.664179570561102 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 2/503 48/18639 0.0416666666666667 1.54398608349901 0.373076848528328 0.664179570561102 GO:0016879 ligase activity, forming carbon-nitrogen bonds 2/503 48/18639 0.0416666666666667 1.54398608349901 0.373076848528328 0.664179570561102 GO:0032266 phosphatidylinositol-3-phosphate binding 2/503 48/18639 0.0416666666666667 1.54398608349901 0.373076848528328 0.664179570561102 GO:0015078 proton transmembrane transporter activity 6/503 185/18639 0.0324324324324324 1.20180538391274 0.382660198672454 0.664179570561102 GO:0001222 transcription corepressor binding 2/503 49/18639 0.0408163265306122 1.5124761634276 0.382754557645245 0.664179570561102 GO:0005004 GPI-linked ephrin receptor activity 2/503 49/18639 0.0408163265306122 1.5124761634276 0.382754557645245 0.664179570561102 GO:0005008 hepatocyte growth factor receptor activity 2/503 49/18639 0.0408163265306122 1.5124761634276 0.382754557645245 0.664179570561102 GO:0005009 insulin receptor activity 2/503 49/18639 0.0408163265306122 1.5124761634276 0.382754557645245 0.664179570561102 GO:0005011 macrophage colony-stimulating factor receptor activity 2/503 49/18639 0.0408163265306122 1.5124761634276 0.382754557645245 0.664179570561102 GO:0005018 platelet-derived growth factor alpha-receptor activity 2/503 49/18639 0.0408163265306122 1.5124761634276 0.382754557645245 0.664179570561102 GO:0005020 stem cell factor receptor activity 2/503 49/18639 0.0408163265306122 1.5124761634276 0.382754557645245 0.664179570561102 GO:0008288 boss receptor activity 2/503 49/18639 0.0408163265306122 1.5124761634276 0.382754557645245 0.664179570561102 GO:0016763 pentosyltransferase activity 2/503 49/18639 0.0408163265306122 1.5124761634276 0.382754557645245 0.664179570561102 GO:0036332 placental growth factor receptor activity 2/503 49/18639 0.0408163265306122 1.5124761634276 0.382754557645245 0.664179570561102 GO:0038062 protein tyrosine kinase collagen receptor activity 2/503 49/18639 0.0408163265306122 1.5124761634276 0.382754557645245 0.664179570561102 GO:0060175 brain-derived neurotrophic factor receptor activity 2/503 49/18639 0.0408163265306122 1.5124761634276 0.382754557645245 0.664179570561102 GO:0060590 ATPase regulator activity 2/503 49/18639 0.0408163265306122 1.5124761634276 0.382754557645245 0.664179570561102 GO:0008135 translation factor activity, RNA binding 3/503 83/18639 0.036144578313253 1.33936142183046 0.388953202873543 0.664179570561102 GO:0003746 translation elongation factor activity 1/503 18/18639 0.0555555555555556 2.05864811133201 0.388999955434923 0.664179570561102 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 1/503 18/18639 0.0555555555555556 2.05864811133201 0.388999955434923 0.664179570561102 GO:0004970 glutamate-gated receptor activity 1/503 18/18639 0.0555555555555556 2.05864811133201 0.388999955434923 0.664179570561102 GO:0015280 ligand-gated sodium channel activity 1/503 18/18639 0.0555555555555556 2.05864811133201 0.388999955434923 0.664179570561102 GO:0015373 monoatomic anion:sodium symporter activity 1/503 18/18639 0.0555555555555556 2.05864811133201 0.388999955434923 0.664179570561102 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 1/503 18/18639 0.0555555555555556 2.05864811133201 0.388999955434923 0.664179570561102 GO:0016854 racemase and epimerase activity 1/503 18/18639 0.0555555555555556 2.05864811133201 0.388999955434923 0.664179570561102 GO:0070064 proline-rich region binding 1/503 18/18639 0.0555555555555556 2.05864811133201 0.388999955434923 0.664179570561102 GO:0098641 cadherin binding involved in cell-cell adhesion 1/503 18/18639 0.0555555555555556 2.05864811133201 0.388999955434923 0.664179570561102 GO:0031406 carboxylic acid binding 6/503 187/18639 0.0320855614973262 1.18895185039496 0.392308787946971 0.664179570561102 GO:0005006 epidermal growth factor receptor activity 2/503 50/18639 0.04 1.48222664015905 0.392367638076682 0.664179570561102 GO:0005007 fibroblast growth factor receptor activity 2/503 50/18639 0.04 1.48222664015905 0.392367638076682 0.664179570561102 GO:0005017 platelet-derived growth factor receptor activity 2/503 50/18639 0.04 1.48222664015905 0.392367638076682 0.664179570561102 GO:0005019 platelet-derived growth factor beta-receptor activity 2/503 50/18639 0.04 1.48222664015905 0.392367638076682 0.664179570561102 GO:0180051 translation factor activity 3/503 84/18639 0.0357142857142857 1.32341664299915 0.396264239408137 0.66949786734289 GO:0003743 translation initiation factor activity 2/503 51/18639 0.0392156862745098 1.45316337270495 0.401912530153729 0.669799966319193 GO:0005021 vascular endothelial growth factor receptor activity 2/503 51/18639 0.0392156862745098 1.45316337270495 0.401912530153729 0.669799966319193 GO:0005030 neurotrophin receptor activity 2/503 51/18639 0.0392156862745098 1.45316337270495 0.401912530153729 0.669799966319193 GO:0016830 carbon-carbon lyase activity 2/503 51/18639 0.0392156862745098 1.45316337270495 0.401912530153729 0.669799966319193 GO:0043177 organic acid binding 6/503 189/18639 0.0317460317460317 1.17637034933258 0.401953483786679 0.669799966319193 GO:0003756 protein disulfide isomerase activity 1/503 19/18639 0.0526315789473684 1.95029821073559 0.405504601931687 0.669799966319193 GO:0005520 insulin-like growth factor binding 1/503 19/18639 0.0526315789473684 1.95029821073559 0.405504601931687 0.669799966319193 GO:0008301 DNA binding, bending 1/503 19/18639 0.0526315789473684 1.95029821073559 0.405504601931687 0.669799966319193 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 1/503 19/18639 0.0526315789473684 1.95029821073559 0.405504601931687 0.669799966319193 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 1/503 19/18639 0.0526315789473684 1.95029821073559 0.405504601931687 0.669799966319193 GO:0046527 glucosyltransferase activity 1/503 19/18639 0.0526315789473684 1.95029821073559 0.405504601931687 0.669799966319193 GO:0050145 nucleoside monophosphate kinase activity 1/503 19/18639 0.0526315789473684 1.95029821073559 0.405504601931687 0.669799966319193 GO:0019902 phosphatase binding 6/503 190/18639 0.0315789473684211 1.17017892644135 0.406772597909364 0.670645528523431 GO:0001664 G protein-coupled receptor binding 9/503 297/18639 0.0303030303030303 1.12289896981746 0.409545566725389 0.67374327096943 GO:0046982 protein heterodimerization activity 11/503 369/18639 0.029810298102981 1.10464044998303 0.411532552731094 0.67374327096943 GO:0140375 immune receptor activity 5/503 156/18639 0.032051282051282 1.18768160269154 0.412794801229272 0.67374327096943 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 4/503 122/18639 0.0327868852459016 1.21493986898282 0.419042148370605 0.67374327096943 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 4/503 122/18639 0.0327868852459016 1.21493986898282 0.419042148370605 0.67374327096943 GO:0005003 ephrin receptor activity 2/503 53/18639 0.0377358490566038 1.39832701901797 0.420784692128165 0.67374327096943 GO:0005005 transmembrane-ephrin receptor activity 2/503 53/18639 0.0377358490566038 1.39832701901797 0.420784692128165 0.67374327096943 GO:0017046 peptide hormone binding 2/503 53/18639 0.0377358490566038 1.39832701901797 0.420784692128165 0.67374327096943 GO:0038064 collagen receptor activity 2/503 53/18639 0.0377358490566038 1.39832701901797 0.420784692128165 0.67374327096943 GO:0140296 general transcription initiation factor binding 2/503 53/18639 0.0377358490566038 1.39832701901797 0.420784692128165 0.67374327096943 GO:0001972 retinoic acid binding 1/503 20/18639 0.05 1.85278330019881 0.421564278904209 0.67374327096943 GO:0010851 cyclase regulator activity 1/503 20/18639 0.05 1.85278330019881 0.421564278904209 0.67374327096943 GO:0015464 acetylcholine receptor activity 1/503 20/18639 0.05 1.85278330019881 0.421564278904209 0.67374327096943 GO:0016408 C-acyltransferase activity 1/503 20/18639 0.05 1.85278330019881 0.421564278904209 0.67374327096943 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 1/503 20/18639 0.05 1.85278330019881 0.421564278904209 0.67374327096943 GO:0042288 MHC class I protein binding 1/503 20/18639 0.05 1.85278330019881 0.421564278904209 0.67374327096943 GO:0140664 ATP-dependent DNA damage sensor activity 1/503 20/18639 0.05 1.85278330019881 0.421564278904209 0.67374327096943 GO:0016651 oxidoreductase activity, acting on NAD(P)H 3/503 88/18639 0.0340909090909091 1.26326134104464 0.425253576205505 0.678417126068854 GO:0003925 G protein activity 2/503 54/18639 0.037037037037037 1.37243207422134 0.430105993940692 0.680330493258595 GO:0015485 cholesterol binding 2/503 54/18639 0.037037037037037 1.37243207422134 0.430105993940692 0.680330493258595 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 2/503 54/18639 0.037037037037037 1.37243207422134 0.430105993940692 0.680330493258595 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 3/503 89/18639 0.0337078651685393 1.24906739339245 0.432427638140367 0.680330493258595 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 3/503 89/18639 0.0337078651685393 1.24906739339245 0.432427638140367 0.680330493258595 GO:0099106 ion channel regulator activity 5/503 160/18639 0.03125 1.15798956262425 0.434084140388703 0.680330493258595 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 1/503 21/18639 0.0476190476190476 1.76455552399886 0.437190959591205 0.680330493258595 GO:0001846 opsonin binding 1/503 21/18639 0.0476190476190476 1.76455552399886 0.437190959591205 0.680330493258595 GO:0008373 sialyltransferase activity 1/503 21/18639 0.0476190476190476 1.76455552399886 0.437190959591205 0.680330493258595 GO:0009931 calcium-dependent protein serine/threonine kinase activity 1/503 21/18639 0.0476190476190476 1.76455552399886 0.437190959591205 0.680330493258595 GO:0019200 carbohydrate kinase activity 1/503 21/18639 0.0476190476190476 1.76455552399886 0.437190959591205 0.680330493258595 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 1/503 21/18639 0.0476190476190476 1.76455552399886 0.437190959591205 0.680330493258595 GO:0070182 DNA polymerase binding 1/503 21/18639 0.0476190476190476 1.76455552399886 0.437190959591205 0.680330493258595 GO:0072542 protein phosphatase activator activity 1/503 21/18639 0.0476190476190476 1.76455552399886 0.437190959591205 0.680330493258595 GO:0140793 histone H2AXY142 phosphatase activity 3/503 90/18639 0.0333333333333333 1.2351888667992 0.439568804788606 0.68283280183449 GO:0170055 lipid transmembrane transporter activity 2/503 56/18639 0.0357142857142857 1.32341664299915 0.448505699523328 0.694248294583606 GO:0005096 GTPase activator activity 8/503 271/18639 0.029520295202952 1.09389419937937 0.448808495069215 0.694248294583606 GO:0004407 histone deacetylase activity 1/503 22/18639 0.0454545454545455 1.68434845472619 0.452396295681313 0.694248294583606 GO:0015377 chloride:monoatomic cation symporter activity 1/503 22/18639 0.0454545454545455 1.68434845472619 0.452396295681313 0.694248294583606 GO:0030021 extracellular matrix structural constituent conferring compression resistance 1/503 22/18639 0.0454545454545455 1.68434845472619 0.452396295681313 0.694248294583606 GO:0031683 G-protein beta/gamma-subunit complex binding 1/503 22/18639 0.0454545454545455 1.68434845472619 0.452396295681313 0.694248294583606 GO:0033558 protein lysine deacetylase activity 1/503 22/18639 0.0454545454545455 1.68434845472619 0.452396295681313 0.694248294583606 GO:0004601 peroxidase activity 2/503 57/18639 0.0350877192982456 1.30019880715706 0.457579361241674 0.699998263853814 GO:0015103 inorganic anion transmembrane transporter activity 5/503 165/18639 0.0303030303030303 1.12289896981746 0.460451311683663 0.699998263853814 GO:0051213 dioxygenase activity 3/503 93/18639 0.032258064516129 1.19534406464439 0.460778511729114 0.699998263853814 GO:0005126 cytokine receptor binding 8/503 275/18639 0.0290909090909091 1.07798301102476 0.465081271908412 0.699998263853814 GO:1901681 sulfur compound binding 8/503 275/18639 0.0290909090909091 1.07798301102476 0.465081271908412 0.699998263853814 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 2/503 58/18639 0.0344827586206897 1.277781586344 0.466566043840787 0.699998263853814 GO:0061980 regulatory RNA binding 2/503 58/18639 0.0344827586206897 1.277781586344 0.466566043840787 0.699998263853814 GO:0005158 insulin receptor binding 1/503 23/18639 0.0434782608695652 1.61111591321635 0.467191625931745 0.699998263853814 GO:0005212 structural constituent of eye lens 1/503 23/18639 0.0434782608695652 1.61111591321635 0.467191625931745 0.699998263853814 GO:0005283 amino acid:sodium symporter activity 1/503 23/18639 0.0434782608695652 1.61111591321635 0.467191625931745 0.699998263853814 GO:0017134 fibroblast growth factor binding 1/503 23/18639 0.0434782608695652 1.61111591321635 0.467191625931745 0.699998263853814 GO:0043274 phospholipase binding 1/503 23/18639 0.0434782608695652 1.61111591321635 0.467191625931745 0.699998263853814 GO:0070577 lysine-acetylated histone binding 1/503 23/18639 0.0434782608695652 1.61111591321635 0.467191625931745 0.699998263853814 GO:0140103 catalytic activity, acting on a glycoprotein 1/503 23/18639 0.0434782608695652 1.61111591321635 0.467191625931745 0.699998263853814 GO:0016874 ligase activity 5/503 167/18639 0.029940119760479 1.10945107796336 0.470901463470932 0.704366944517229 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 2/503 59/18639 0.0338983050847458 1.25612427132123 0.475463828354428 0.705607943865929 GO:0016247 channel regulator activity 5/503 168/18639 0.0297619047619048 1.10284720249929 0.47610278965557 0.705607943865929 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 4/503 132/18639 0.0303030303030303 1.12289896981746 0.478784366864687 0.705607943865929 GO:0001091 RNA polymerase II general transcription initiation factor binding 1/503 24/18639 0.0416666666666667 1.54398608349901 0.481587984556387 0.705607943865929 GO:0004806 triacylglycerol lipase activity 1/503 24/18639 0.0416666666666667 1.54398608349901 0.481587984556387 0.705607943865929 GO:0015149 hexose transmembrane transporter activity 1/503 24/18639 0.0416666666666667 1.54398608349901 0.481587984556387 0.705607943865929 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 1/503 24/18639 0.0416666666666667 1.54398608349901 0.481587984556387 0.705607943865929 GO:0050431 transforming growth factor beta binding 1/503 24/18639 0.0416666666666667 1.54398608349901 0.481587984556387 0.705607943865929 GO:0055056 D-glucose transmembrane transporter activity 1/503 24/18639 0.0416666666666667 1.54398608349901 0.481587984556387 0.705607943865929 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 1/503 24/18639 0.0416666666666667 1.54398608349901 0.481587984556387 0.705607943865929 GO:0140033 acetylation-dependent protein binding 1/503 24/18639 0.0416666666666667 1.54398608349901 0.481587984556387 0.705607943865929 GO:0140612 DNA damage sensor activity 1/503 24/18639 0.0416666666666667 1.54398608349901 0.481587984556387 0.705607943865929 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 2/503 60/18639 0.0333333333333333 1.2351888667992 0.484270962209059 0.705607943865929 GO:0141108 transporter regulator activity 5/503 170/18639 0.0294117647058824 1.08987252952871 0.486454364888815 0.705607943865929 GO:0005516 calmodulin binding 6/503 207/18639 0.0289855072463768 1.07407727547757 0.48769361307801 0.705607943865929 GO:0019905 syntaxin binding 2/503 61/18639 0.0327868852459016 1.21493986898282 0.492985851672779 0.705607943865929 GO:0004725 protein tyrosine phosphatase activity 3/503 98/18639 0.0306122448979592 1.1343571225707 0.495326492068907 0.705607943865929 GO:0001848 complement binding 1/503 25/18639 0.04 1.48222664015905 0.495596109389486 0.705607943865929 GO:0003707 nuclear steroid receptor activity 1/503 25/18639 0.04 1.48222664015905 0.495596109389486 0.705607943865929 GO:0005537 D-mannose binding 1/503 25/18639 0.04 1.48222664015905 0.495596109389486 0.705607943865929 GO:0008139 nuclear localization sequence binding 1/503 25/18639 0.04 1.48222664015905 0.495596109389486 0.705607943865929 GO:0015296 monoatomic anion:monoatomic cation symporter activity 1/503 25/18639 0.04 1.48222664015905 0.495596109389486 0.705607943865929 GO:0015645 fatty acid ligase activity 1/503 25/18639 0.04 1.48222664015905 0.495596109389486 0.705607943865929 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 1/503 25/18639 0.04 1.48222664015905 0.495596109389486 0.705607943865929 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 1/503 25/18639 0.04 1.48222664015905 0.495596109389486 0.705607943865929 GO:0019211 phosphatase activator activity 1/503 25/18639 0.04 1.48222664015905 0.495596109389486 0.705607943865929 GO:0019706 protein-cysteine S-palmitoyltransferase activity 1/503 25/18639 0.04 1.48222664015905 0.495596109389486 0.705607943865929 GO:0019707 protein-cysteine S-acyltransferase activity 1/503 25/18639 0.04 1.48222664015905 0.495596109389486 0.705607943865929 GO:0042974 nuclear retinoic acid receptor binding 1/503 25/18639 0.04 1.48222664015905 0.495596109389486 0.705607943865929 GO:0120515 fatty acid-CoA ligase activity 1/503 25/18639 0.04 1.48222664015905 0.495596109389486 0.705607943865929 GO:0140030 modification-dependent protein binding 5/503 173/18639 0.0289017341040462 1.07097300589526 0.501843790545536 0.71243511198744 GO:0016922 nuclear receptor binding 4/503 137/18639 0.0291970802919708 1.08191725559054 0.507765401756998 0.71243511198744 GO:0004529 DNA exonuclease activity 1/503 26/18639 0.0384615384615385 1.42521792322985 0.509226449830933 0.71243511198744 GO:0005160 transforming growth factor beta receptor binding 1/503 26/18639 0.0384615384615385 1.42521792322985 0.509226449830933 0.71243511198744 GO:0005227 calcium-activated cation channel activity 1/503 26/18639 0.0384615384615385 1.42521792322985 0.509226449830933 0.71243511198744 GO:0008066 glutamate receptor activity 1/503 26/18639 0.0384615384615385 1.42521792322985 0.509226449830933 0.71243511198744 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 1/503 26/18639 0.0384615384615385 1.42521792322985 0.509226449830933 0.71243511198744 GO:0008157 protein phosphatase 1 binding 1/503 26/18639 0.0384615384615385 1.42521792322985 0.509226449830933 0.71243511198744 GO:0015145 monosaccharide transmembrane transporter activity 1/503 26/18639 0.0384615384615385 1.42521792322985 0.509226449830933 0.71243511198744 GO:0030507 spectrin binding 1/503 26/18639 0.0384615384615385 1.42521792322985 0.509226449830933 0.71243511198744 GO:0034237 protein kinase A regulatory subunit binding 1/503 26/18639 0.0384615384615385 1.42521792322985 0.509226449830933 0.71243511198744 GO:0004252 serine-type endopeptidase activity 5/503 176/18639 0.0284090909090909 1.05271778420387 0.517052178919726 0.715197373227682 GO:0004536 DNA nuclease activity 2/503 64/18639 0.03125 1.15798956262425 0.518563348354131 0.715197373227682 GO:0043021 ribonucleoprotein complex binding 5/503 177/18639 0.0282485875706215 1.04677022610102 0.522078564951529 0.715197373227682 GO:0015171 amino acid transmembrane transporter activity 3/503 102/18639 0.0294117647058824 1.08987252952871 0.522151151104297 0.715197373227682 GO:0001671 ATPase activator activity 1/503 27/18639 0.037037037037037 1.37243207422134 0.52248917457896 0.715197373227682 GO:0004364 glutathione transferase activity 1/503 27/18639 0.037037037037037 1.37243207422134 0.52248917457896 0.715197373227682 GO:0005044 scavenger receptor activity 1/503 27/18639 0.037037037037037 1.37243207422134 0.52248917457896 0.715197373227682 GO:0008320 protein transmembrane transporter activity 1/503 27/18639 0.037037037037037 1.37243207422134 0.52248917457896 0.715197373227682 GO:0008395 steroid hydroxylase activity 1/503 27/18639 0.037037037037037 1.37243207422134 0.52248917457896 0.715197373227682 GO:0016405 CoA-ligase activity 1/503 27/18639 0.037037037037037 1.37243207422134 0.52248917457896 0.715197373227682 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 1/503 27/18639 0.037037037037037 1.37243207422134 0.52248917457896 0.715197373227682 GO:0023026 MHC class II protein complex binding 1/503 27/18639 0.037037037037037 1.37243207422134 0.52248917457896 0.715197373227682 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 1/503 27/18639 0.037037037037037 1.37243207422134 0.52248917457896 0.715197373227682 GO:0035255 ionotropic glutamate receptor binding 1/503 27/18639 0.037037037037037 1.37243207422134 0.52248917457896 0.715197373227682 GO:0004713 protein tyrosine kinase activity 4/503 140/18639 0.0285714285714286 1.05873331439932 0.524803643908599 0.71725860115089 GO:0120013 lipid transfer activity 2/503 65/18639 0.0307692307692308 1.14017433858388 0.526896251169502 0.719010730442074 GO:0005242 inward rectifier potassium channel activity 1/503 28/18639 0.0357142857142857 1.32341664299915 0.535394179155942 0.723924751389208 GO:0016866 intramolecular transferase activity 1/503 28/18639 0.0357142857142857 1.32341664299915 0.535394179155942 0.723924751389208 GO:0046875 ephrin receptor binding 1/503 28/18639 0.0357142857142857 1.32341664299915 0.535394179155942 0.723924751389208 GO:0051019 mitogen-activated protein kinase binding 1/503 28/18639 0.0357142857142857 1.32341664299915 0.535394179155942 0.723924751389208 GO:0051119 sugar transmembrane transporter activity 1/503 28/18639 0.0357142857142857 1.32341664299915 0.535394179155942 0.723924751389208 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 1/503 28/18639 0.0357142857142857 1.32341664299915 0.535394179155942 0.723924751389208 GO:0004181 metallocarboxypeptidase activity 1/503 29/18639 0.0344827586206897 1.277781586344 0.547951093232808 0.733386399591123 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 1/503 29/18639 0.0344827586206897 1.277781586344 0.547951093232808 0.733386399591123 GO:0005416 amino acid:monoatomic cation symporter activity 1/503 29/18639 0.0344827586206897 1.277781586344 0.547951093232808 0.733386399591123 GO:0016417 S-acyltransferase activity 1/503 29/18639 0.0344827586206897 1.277781586344 0.547951093232808 0.733386399591123 GO:0097472 cyclin-dependent protein kinase activity 1/503 29/18639 0.0344827586206897 1.277781586344 0.547951093232808 0.733386399591123 GO:0099604 ligand-gated calcium channel activity 1/503 29/18639 0.0344827586206897 1.277781586344 0.547951093232808 0.733386399591123 GO:0000149 SNARE binding 3/503 106/18639 0.0283018867924528 1.04874526426348 0.548179462152102 0.733386399591123 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 2/503 68/18639 0.0294117647058824 1.08987252952871 0.551303485380107 0.734243530829062 GO:0030145 manganese ion binding 2/503 68/18639 0.0294117647058824 1.08987252952871 0.551303485380107 0.734243530829062 GO:0032934 sterol binding 2/503 68/18639 0.0294117647058824 1.08987252952871 0.551303485380107 0.734243530829062 GO:0002039 p53 binding 2/503 69/18639 0.0289855072463768 1.07407727547757 0.559239831418327 0.735944817737608 GO:0008080 N-acetyltransferase activity 2/503 69/18639 0.0289855072463768 1.07407727547757 0.559239831418327 0.735944817737608 GO:0016279 protein-lysine N-methyltransferase activity 2/503 69/18639 0.0289855072463768 1.07407727547757 0.559239831418327 0.735944817737608 GO:0098960 postsynaptic neurotransmitter receptor activity 2/503 69/18639 0.0289855072463768 1.07407727547757 0.559239831418327 0.735944817737608 GO:0022839 monoatomic ion-gated channel activity 1/503 30/18639 0.0333333333333333 1.2351888667992 0.560169287757468 0.735944817737608 GO:0031210 phosphatidylcholine binding 1/503 30/18639 0.0333333333333333 1.2351888667992 0.560169287757468 0.735944817737608 GO:0033612 receptor serine/threonine kinase binding 1/503 30/18639 0.0333333333333333 1.2351888667992 0.560169287757468 0.735944817737608 GO:0051721 protein phosphatase 2A binding 1/503 30/18639 0.0333333333333333 1.2351888667992 0.560169287757468 0.735944817737608 GO:0070566 adenylyltransferase activity 1/503 30/18639 0.0333333333333333 1.2351888667992 0.560169287757468 0.735944817737608 GO:0005496 steroid binding 3/503 108/18639 0.0277777777777778 1.029324055666 0.560877899425731 0.735944817737608 GO:0015085 calcium ion transmembrane transporter activity 4/503 147/18639 0.0272108843537415 1.00831744228507 0.563408917043514 0.7381738691545 GO:0008028 monocarboxylic acid transmembrane transporter activity 2/503 70/18639 0.0285714285714286 1.05873331439932 0.567075625015651 0.739791487554717 GO:0016278 lysine N-methyltransferase activity 2/503 70/18639 0.0285714285714286 1.05873331439932 0.567075625015651 0.739791487554717 GO:0004620 phospholipase activity 3/503 109/18639 0.0275229357798165 1.01988071570577 0.567145672533492 0.739791487554717 GO:0005184 neuropeptide hormone activity 1/503 31/18639 0.032258064516129 1.19534406464439 0.572057881892455 0.741835294208491 GO:0005310 dicarboxylic acid transmembrane transporter activity 1/503 31/18639 0.032258064516129 1.19534406464439 0.572057881892455 0.741835294208491 GO:0005452 solute:inorganic anion antiporter activity 1/503 31/18639 0.032258064516129 1.19534406464439 0.572057881892455 0.741835294208491 GO:0072349 modified amino acid transmembrane transporter activity 1/503 31/18639 0.032258064516129 1.19534406464439 0.572057881892455 0.741835294208491 GO:0140299 molecular sensor activity 2/503 71/18639 0.028169014084507 1.04382157757679 0.574810503631445 0.744316666746119 GO:0046943 carboxylic acid transmembrane transporter activity 5/503 188/18639 0.0265957446808511 0.985523032020642 0.575769686414027 0.74447188316216 GO:0005342 organic acid transmembrane transporter activity 5/503 189/18639 0.0264550264550265 0.980308624443813 0.580492952789771 0.748086763068296 GO:0022884 macromolecule transmembrane transporter activity 1/503 32/18639 0.03125 1.15798956262425 0.583625749766923 0.748086763068296 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1/503 32/18639 0.03125 1.15798956262425 0.583625749766923 0.748086763068296 GO:0042910 xenobiotic transmembrane transporter activity 1/503 32/18639 0.03125 1.15798956262425 0.583625749766923 0.748086763068296 GO:0140142 nucleocytoplasmic carrier activity 1/503 32/18639 0.03125 1.15798956262425 0.583625749766923 0.748086763068296 GO:0160041 neuropeptide activity 1/503 32/18639 0.03125 1.15798956262425 0.583625749766923 0.748086763068296 GO:0043539 protein serine/threonine kinase activator activity 2/503 73/18639 0.0273972602739726 1.01522372613633 0.589976523939409 0.755135897163428 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 1/503 33/18639 0.0303030303030303 1.12289896981746 0.594881527047905 0.758132061050994 GO:0030296 protein tyrosine kinase activator activity 1/503 33/18639 0.0303030303030303 1.12289896981746 0.594881527047905 0.758132061050994 GO:0140311 protein sequestering activity 1/503 33/18639 0.0303030303030303 1.12289896981746 0.594881527047905 0.758132061050994 GO:0005506 iron ion binding 4/503 154/18639 0.025974025974026 0.962484831272108 0.600239095085655 0.763246760854597 GO:0035401 histone H3Y41 kinase activity 3/503 115/18639 0.0260869565217391 0.966669547929812 0.603576060702917 0.763246760854597 GO:0140801 histone H2AXY142 kinase activity 3/503 115/18639 0.0260869565217391 0.966669547929812 0.603576060702917 0.763246760854597 GO:0008236 serine-type peptidase activity 5/503 194/18639 0.0257731958762887 0.955042938246808 0.603680261906972 0.763246760854597 GO:0019003 GDP binding 2/503 75/18639 0.0266666666666667 0.988151093439364 0.604736760053088 0.763246760854597 GO:0004386 helicase activity 4/503 155/18639 0.0258064516129032 0.956275251715513 0.605346027370066 0.763246760854597 GO:0015035 protein-disulfide reductase activity 1/503 34/18639 0.0294117647058824 1.08987252952871 0.605833617335711 0.763246760854597 GO:0052866 phosphatidylinositol phosphate phosphatase activity 1/503 34/18639 0.0294117647058824 1.08987252952871 0.605833617335711 0.763246760854597 GO:0005125 cytokine activity 6/503 234/18639 0.0256410256410256 0.950145282153234 0.607452375354154 0.763246760854597 GO:0016791 phosphatase activity 7/503 273/18639 0.0256410256410256 0.950145282153234 0.607499676621585 0.763246760854597 GO:0005343 organic acid:sodium symporter activity 1/503 35/18639 0.0285714285714286 1.05873331439932 0.616490198388123 0.77017859995812 GO:0016229 steroid dehydrogenase activity 1/503 35/18639 0.0285714285714286 1.05873331439932 0.616490198388123 0.77017859995812 GO:0043015 gamma-tubulin binding 1/503 35/18639 0.0285714285714286 1.05873331439932 0.616490198388123 0.77017859995812 GO:0140566 histone reader activity 1/503 35/18639 0.0285714285714286 1.05873331439932 0.616490198388123 0.77017859995812 GO:0140658 ATP-dependent chromatin remodeler activity 4/503 158/18639 0.0253164556962025 0.93811812668294 0.620426742833127 0.774006358499274 GO:0017171 serine hydrolase activity 5/503 198/18639 0.0252525252525253 0.935749141514549 0.621695379051123 0.774499720812284 GO:0004190 aspartic-type endopeptidase activity 1/503 36/18639 0.0277777777777778 1.029324055666 0.626859228177995 0.77548693918254 GO:0045505 dynein intermediate chain binding 1/503 36/18639 0.0277777777777778 1.029324055666 0.626859228177995 0.77548693918254 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 1/503 36/18639 0.0277777777777778 1.029324055666 0.626859228177995 0.77548693918254 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 1/503 36/18639 0.0277777777777778 1.029324055666 0.626859228177995 0.77548693918254 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 1/503 36/18639 0.0277777777777778 1.029324055666 0.626859228177995 0.77548693918254 GO:0033293 monocarboxylic acid binding 2/503 79/18639 0.0253164556962025 0.93811812668294 0.633041545618777 0.781429150552634 GO:0004866 endopeptidase inhibitor activity 4/503 161/18639 0.0248447204968944 0.920637664695059 0.635140986184648 0.781429150552634 GO:0019213 deacetylase activity 1/503 37/18639 0.027027027027027 1.00150448659395 0.636948450788674 0.781429150552634 GO:0022829 wide pore channel activity 1/503 37/18639 0.027027027027027 1.00150448659395 0.636948450788674 0.781429150552634 GO:0023023 MHC protein complex binding 1/503 37/18639 0.027027027027027 1.00150448659395 0.636948450788674 0.781429150552634 GO:0070001 aspartic-type peptidase activity 1/503 37/18639 0.027027027027027 1.00150448659395 0.636948450788674 0.781429150552634 GO:0008083 growth factor activity 4/503 162/18639 0.0246913580246914 0.914954716147559 0.639963073009125 0.784043157125821 GO:0019001 guanyl nucleotide binding 10/503 400/18639 0.025 0.926391650099404 0.641739222722796 0.784053292775647 GO:0032561 guanyl ribonucleotide binding 10/503 400/18639 0.025 0.926391650099404 0.641739222722796 0.784053292775647 GO:0015101 organic cation transmembrane transporter activity 2/503 81/18639 0.0246913580246914 0.914954716147559 0.646589642819495 0.785864262614351 GO:0005501 retinoid binding 1/503 38/18639 0.0263157894736842 0.975149105367793 0.646765402151608 0.785864262614351 GO:0019840 isoprenoid binding 1/503 38/18639 0.0263157894736842 0.975149105367793 0.646765402151608 0.785864262614351 GO:0042887 amide transmembrane transporter activity 1/503 38/18639 0.0263157894736842 0.975149105367793 0.646765402151608 0.785864262614351 GO:0042578 phosphoric ester hydrolase activity 9/503 363/18639 0.0247933884297521 0.918735520759739 0.648703569510837 0.787140993373614 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 1/503 39/18639 0.0256410256410256 0.950145282153234 0.656317415630332 0.793124724338017 GO:0016776 phosphotransferase activity, phosphate group as acceptor 1/503 39/18639 0.0256410256410256 0.950145282153234 0.656317415630332 0.793124724338017 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 1/503 39/18639 0.0256410256410256 0.950145282153234 0.656317415630332 0.793124724338017 GO:0030331 nuclear estrogen receptor binding 1/503 40/18639 0.025 0.926391650099404 0.665611627454952 0.801082107941035 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 1/503 40/18639 0.025 0.926391650099404 0.665611627454952 0.801082107941035 GO:0071855 neuropeptide receptor binding 1/503 40/18639 0.025 0.926391650099404 0.665611627454952 0.801082107941035 GO:0030414 peptidase inhibitor activity 4/503 169/18639 0.0236686390532544 0.877057183526063 0.672540348826572 0.801096344101558 GO:0008094 ATP-dependent activity, acting on DNA 5/503 210/18639 0.0238095238095238 0.882277761999432 0.67271547323195 0.801096344101558 GO:0003924 GTPase activity 8/503 331/18639 0.0241691842900302 0.895605220639907 0.673340265919072 0.801096344101558 GO:0001530 lipopolysaccharide binding 1/503 41/18639 0.024390243902439 0.903796731804296 0.67465498201112 0.801096344101558 GO:0004812 aminoacyl-tRNA ligase activity 1/503 41/18639 0.024390243902439 0.903796731804296 0.67465498201112 0.801096344101558 GO:0008137 NADH dehydrogenase (ubiquinone) activity 1/503 41/18639 0.024390243902439 0.903796731804296 0.67465498201112 0.801096344101558 GO:0008227 G protein-coupled amine receptor activity 1/503 41/18639 0.024390243902439 0.903796731804296 0.67465498201112 0.801096344101558 GO:0016875 ligase activity, forming carbon-oxygen bonds 1/503 41/18639 0.024390243902439 0.903796731804296 0.67465498201112 0.801096344101558 GO:0042287 MHC protein binding 1/503 41/18639 0.024390243902439 0.903796731804296 0.67465498201112 0.801096344101558 GO:0140318 protein transporter activity 1/503 41/18639 0.024390243902439 0.903796731804296 0.67465498201112 0.801096344101558 GO:0016209 antioxidant activity 2/503 86/18639 0.0232558139534884 0.861759674511073 0.678723517391724 0.804849946425748 GO:0004520 DNA endonuclease activity 1/503 42/18639 0.0238095238095238 0.882277761999432 0.683454236987376 0.808491091598946 GO:0008081 phosphoric diester hydrolase activity 2/503 87/18639 0.0229885057471264 0.851854390896003 0.684857050484519 0.808491091598946 GO:0016298 lipase activity 3/503 130/18639 0.0230769230769231 0.855130753937911 0.685440023542736 0.808491091598946 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 3/503 130/18639 0.0230769230769231 0.855130753937911 0.685440023542736 0.808491091598946 GO:0140097 catalytic activity, acting on DNA 8/503 336/18639 0.0238095238095238 0.882277761999432 0.689373540072506 0.812050903113297 GO:0005262 calcium channel activity 3/503 131/18639 0.0229007633587786 0.848603038258996 0.690421238707585 0.812206417418604 GO:0005525 GTP binding 9/503 378/18639 0.0238095238095238 0.882277761999432 0.695026005655763 0.816540486114784 GO:0004721 phosphoprotein phosphatase activity 4/503 175/18639 0.0228571428571429 0.846986651519455 0.698801728387887 0.819534844818498 GO:0003954 NADH dehydrogenase activity 1/503 44/18639 0.0227272727272727 0.842174227363094 0.700346575391682 0.819534844818498 GO:0030020 extracellular matrix structural constituent conferring tensile strength 1/503 44/18639 0.0227272727272727 0.842174227363094 0.700346575391682 0.819534844818498 GO:0042605 peptide antigen binding 1/503 45/18639 0.0222222222222222 0.823459244532803 0.708452285129675 0.827927769314917 GO:0015297 antiporter activity 3/503 135/18639 0.0222222222222222 0.823459244532803 0.709753234802401 0.828356735881223 GO:0043178 alcohol binding 2/503 92/18639 0.0217391304347826 0.805557956608177 0.714095853020122 0.828375473501593 GO:0002020 protease binding 3/503 136/18639 0.0220588235294118 0.817404397146533 0.714438824384125 0.828375473501593 GO:0016779 nucleotidyltransferase activity 3/503 136/18639 0.0220588235294118 0.817404397146533 0.714438824384125 0.828375473501593 GO:0099094 ligand-gated monoatomic cation channel activity 3/503 136/18639 0.0220588235294118 0.817404397146533 0.714438824384125 0.828375473501593 GO:0140789 histone phosphatase activity 3/503 136/18639 0.0220588235294118 0.817404397146533 0.714438824384125 0.828375473501593 GO:0004180 carboxypeptidase activity 1/503 46/18639 0.0217391304347826 0.805557956608177 0.716339157270138 0.82841308018072 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 1/503 46/18639 0.0217391304347826 0.805557956608177 0.716339157270138 0.82841308018072 GO:0005504 fatty acid binding 1/503 47/18639 0.0212765957446809 0.788418425616514 0.724013088528844 0.834025466915694 GO:0061749 forked DNA-dependent helicase activity 1/503 47/18639 0.0212765957446809 0.788418425616514 0.724013088528844 0.834025466915694 GO:1990518 single-stranded 3'-5' DNA helicase activity 1/503 47/18639 0.0212765957446809 0.788418425616514 0.724013088528844 0.834025466915694 GO:0004867 serine-type endopeptidase inhibitor activity 2/503 95/18639 0.0210526315789474 0.780119284294234 0.730524417826349 0.835035518293476 GO:0008276 protein methyltransferase activity 2/503 95/18639 0.0210526315789474 0.780119284294234 0.730524417826349 0.835035518293476 GO:0009378 four-way junction helicase activity 1/503 48/18639 0.0208333333333333 0.771993041749503 0.731479817039493 0.835035518293476 GO:0036121 double-stranded DNA helicase activity 1/503 48/18639 0.0208333333333333 0.771993041749503 0.731479817039493 0.835035518293476 GO:0038187 pattern recognition receptor activity 1/503 48/18639 0.0208333333333333 0.771993041749503 0.731479817039493 0.835035518293476 GO:0043138 3'-5' DNA helicase activity 1/503 48/18639 0.0208333333333333 0.771993041749503 0.731479817039493 0.835035518293476 GO:0140693 molecular condensate scaffold activity 1/503 48/18639 0.0208333333333333 0.771993041749503 0.731479817039493 0.835035518293476 GO:0061135 endopeptidase regulator activity 4/503 184/18639 0.0217391304347826 0.805557956608177 0.735300750203555 0.837833466055758 GO:0016407 acetyltransferase activity 2/503 96/18639 0.0208333333333333 0.771993041749503 0.735819921147052 0.837833466055758 GO:0035254 glutamate receptor binding 1/503 49/18639 0.0204081632653061 0.756238081713799 0.738744926610207 0.840085576799043 GO:0030594 neurotransmitter receptor activity 2/503 97/18639 0.0206185567010309 0.764034350597446 0.741026585149961 0.841601256117817 GO:0015276 ligand-gated monoatomic ion channel activity 4/503 186/18639 0.021505376344086 0.796896043096261 0.742943145644086 0.842698938857167 GO:0008170 N-methyltransferase activity 2/503 98/18639 0.0204081632653061 0.756238081713799 0.746145337089149 0.845250209448372 GO:0022834 ligand-gated channel activity 4/503 188/18639 0.0212765957446809 0.788418425616514 0.750416956752379 0.847255958309101 GO:0005048 signal sequence binding 1/503 51/18639 0.0196078431372549 0.726581686352473 0.752691877280239 0.847255958309101 GO:0005272 sodium channel activity 1/503 51/18639 0.0196078431372549 0.726581686352473 0.752691877280239 0.847255958309101 GO:0016597 amino acid binding 1/503 51/18639 0.0196078431372549 0.726581686352473 0.752691877280239 0.847255958309101 GO:0030544 Hsp70 protein binding 1/503 51/18639 0.0196078431372549 0.726581686352473 0.752691877280239 0.847255958309101 GO:0043130 ubiquitin binding 2/503 100/18639 0.02 0.741113320079523 0.756122885935278 0.850039290018493 GO:0016251 RNA polymerase II general transcription initiation factor activity 1/503 53/18639 0.0188679245283019 0.699163509508984 0.765895679155304 0.8566828088408 GO:0034212 protein N-acetyltransferase activity 1/503 53/18639 0.0188679245283019 0.699163509508984 0.765895679155304 0.8566828088408 GO:0051018 protein kinase A binding 1/503 53/18639 0.0188679245283019 0.699163509508984 0.765895679155304 0.8566828088408 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 1/503 53/18639 0.0188679245283019 0.699163509508984 0.765895679155304 0.8566828088408 GO:0017069 snRNA binding 1/503 54/18639 0.0185185185185185 0.686216037110669 0.772231333593315 0.860514061428731 GO:0050661 NADP binding 1/503 54/18639 0.0185185185185185 0.686216037110669 0.772231333593315 0.860514061428731 GO:0051287 NAD binding 1/503 54/18639 0.0185185185185185 0.686216037110669 0.772231333593315 0.860514061428731 GO:0008374 O-acyltransferase activity 1/503 55/18639 0.0181818181818182 0.673739381890475 0.778395855476692 0.866295011051224 GO:0008013 beta-catenin binding 2/503 106/18639 0.0188679245283019 0.699163509508984 0.784046000496776 0.870785171868496 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 1/503 56/18639 0.0178571428571429 0.661708321499574 0.784393858312208 0.870785171868496 GO:0015291 secondary active transmembrane transporter activity 6/503 287/18639 0.0209059233449477 0.774682912975111 0.790180983840372 0.876113165833013 GO:0008408 3'-5' exonuclease activity 1/503 58/18639 0.0172413793103448 0.638890793172002 0.795908143537925 0.880262497902917 GO:0017116 single-stranded DNA helicase activity 1/503 58/18639 0.0172413793103448 0.638890793172002 0.795908143537925 0.880262497902917 GO:0015459 potassium channel regulator activity 1/503 59/18639 0.0169491525423729 0.628062135660613 0.801433045523848 0.883069703577208 GO:0031593 polyubiquitin modification-dependent protein binding 1/503 59/18639 0.0169491525423729 0.628062135660613 0.801433045523848 0.883069703577208 GO:0036002 pre-mRNA binding 1/503 59/18639 0.0169491525423729 0.628062135660613 0.801433045523848 0.883069703577208 GO:0001098 basal transcription machinery binding 1/503 60/18639 0.0166666666666667 0.617594433399602 0.806808674054607 0.885692195404005 GO:0001099 basal RNA polymerase II transcription machinery binding 1/503 60/18639 0.0166666666666667 0.617594433399602 0.806808674054607 0.885692195404005 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1/503 60/18639 0.0166666666666667 0.617594433399602 0.806808674054607 0.885692195404005 GO:0043022 ribosome binding 2/503 112/18639 0.0178571428571429 0.661708321499574 0.809123123219936 0.887027854044686 GO:0015079 potassium ion transmembrane transporter activity 3/503 160/18639 0.01875 0.694793737574553 0.810025436049826 0.887027854044686 GO:0015179 L-amino acid transmembrane transporter activity 1/503 62/18639 0.0161290322580645 0.597672032322196 0.817128103605315 0.893702377186085 GO:0005507 copper ion binding 1/503 63/18639 0.0158730158730159 0.588185174666288 0.822079633124964 0.894624737094303 GO:0022824 transmitter-gated monoatomic ion channel activity 1/503 63/18639 0.0158730158730159 0.588185174666288 0.822079633124964 0.894624737094303 GO:0022835 transmitter-gated channel activity 1/503 63/18639 0.0158730158730159 0.588185174666288 0.822079633124964 0.894624737094303 GO:1901682 sulfur compound transmembrane transporter activity 1/503 63/18639 0.0158730158730159 0.588185174666288 0.822079633124964 0.894624737094303 GO:0015081 sodium ion transmembrane transporter activity 3/503 164/18639 0.0182926829268293 0.677847548853222 0.823014414282921 0.894624737094303 GO:0019843 rRNA binding 1/503 65/18639 0.0153846153846154 0.570087169291941 0.831584869130247 0.901730781073996 GO:0160215 deacylase activity 1/503 65/18639 0.0153846153846154 0.570087169291941 0.831584869130247 0.901730781073996 GO:0032182 ubiquitin-like protein binding 2/503 120/18639 0.0166666666666667 0.617594433399602 0.838512160085384 0.908132217333011 GO:0003697 single-stranded DNA binding 2/503 121/18639 0.0165289256198347 0.612490347173159 0.841883376289684 0.910671408254817 GO:0140223 general transcription initiation factor activity 1/503 68/18639 0.0147058823529412 0.544936264764355 0.84490086043145 0.912822245070275 GO:0008201 heparin binding 3/503 172/18639 0.0174418604651163 0.646319755883305 0.846730256768598 0.91368581235249 GO:0005244 voltage-gated monoatomic ion channel activity 3/503 173/18639 0.0173410404624277 0.642583803537158 0.849492211859925 0.915552359562276 GO:0005267 potassium channel activity 2/503 124/18639 0.0161290322580645 0.597672032322196 0.851617709160063 0.916729257311864 GO:0022832 voltage-gated channel activity 3/503 175/18639 0.0171428571428571 0.635239988639591 0.854886550777661 0.919132570351255 GO:0005216 monoatomic ion channel activity 9/503 448/18639 0.0200892857142857 0.744421861687021 0.857445587644885 0.920767840485488 GO:0022836 gated channel activity 6/503 318/18639 0.0188679245283019 0.699163509508984 0.862204648486851 0.924034153352408 GO:0061134 peptidase regulator activity 4/503 226/18639 0.0176991150442478 0.655852495645595 0.862570776748358 0.924034153352408 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 2/503 128/18639 0.015625 0.578994781312127 0.8637480333129 0.92417913817677 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 1/503 73/18639 0.0136986301369863 0.507611863068166 0.864799954884572 0.924189831304355 GO:0003678 DNA helicase activity 1/503 74/18639 0.0135135135135135 0.500752243296975 0.868462866803836 0.926987440258727 GO:0003725 double-stranded RNA binding 1/503 75/18639 0.0133333333333333 0.494075546719682 0.872026733111278 0.929672731093394 GO:0003724 RNA helicase activity 1/503 77/18639 0.012987012987013 0.481242415636054 0.878867948952461 0.935841381417566 GO:0008186 ATP-dependent activity, acting on RNA 1/503 79/18639 0.0126582278481013 0.46905906334147 0.885344134108208 0.936893465198093 GO:0015370 solute:sodium symporter activity 1/503 79/18639 0.0126582278481013 0.46905906334147 0.885344134108208 0.936893465198093 GO:0140597 protein carrier chaperone 3/503 188/18639 0.0159574468085106 0.591313819212385 0.88599610473569 0.936893465198093 GO:0033192 calmodulin-dependent protein phosphatase activity 1/503 81/18639 0.0123456790123457 0.457477358073779 0.891474729004724 0.936893465198093 GO:0140791 histone H2AXS140 phosphatase activity 1/503 81/18639 0.0123456790123457 0.457477358073779 0.891474729004724 0.936893465198093 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 1/503 81/18639 0.0123456790123457 0.457477358073779 0.891474729004724 0.936893465198093 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 1/503 81/18639 0.0123456790123457 0.457477358073779 0.891474729004724 0.936893465198093 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 1/503 81/18639 0.0123456790123457 0.457477358073779 0.891474729004724 0.936893465198093 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 1/503 81/18639 0.0123456790123457 0.457477358073779 0.891474729004724 0.936893465198093 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 1/503 81/18639 0.0123456790123457 0.457477358073779 0.891474729004724 0.936893465198093 GO:1990439 MAP kinase serine/threonine phosphatase activity 1/503 81/18639 0.0123456790123457 0.457477358073779 0.891474729004724 0.936893465198093 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 1/503 82/18639 0.0121951219512195 0.451898365902148 0.894416221154235 0.937292389855869 GO:0033549 MAP kinase phosphatase activity 1/503 82/18639 0.0121951219512195 0.451898365902148 0.894416221154235 0.937292389855869 GO:0005539 glycosaminoglycan binding 4/503 242/18639 0.0165289256198347 0.612490347173159 0.895024412861241 0.937292389855869 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 1/503 83/18639 0.0120481927710843 0.446453807276821 0.897278140686456 0.938544470269913 GO:0004527 exonuclease activity 1/503 84/18639 0.0119047619047619 0.441138880999716 0.900062636010594 0.939241833107526 GO:0017018 myosin phosphatase activity 1/503 84/18639 0.0119047619047619 0.441138880999716 0.900062636010594 0.939241833107526 GO:0140104 molecular carrier activity 4/503 249/18639 0.0160642570281124 0.595271743035761 0.906971440433539 0.945339209946591 GO:0004197 cysteine-type endopeptidase activity 1/503 88/18639 0.0113636363636364 0.421087113681547 0.910467349561105 0.947869177301292 GO:0003727 single-stranded RNA binding 1/503 89/18639 0.0112359550561798 0.416355797797485 0.912894977353179 0.948667882804606 GO:0000510 H3-H4 histone complex chaperone activity 2/503 151/18639 0.0132450331125828 0.490803523231472 0.9174900548006 0.948667882804606 GO:0140584 chromatin extrusion motor activity 2/503 151/18639 0.0132450331125828 0.490803523231472 0.9174900548006 0.948667882804606 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 2/503 151/18639 0.0132450331125828 0.490803523231472 0.9174900548006 0.948667882804606 GO:0140849 ATP-dependent H2AZ histone chaperone activity 2/503 151/18639 0.0132450331125828 0.490803523231472 0.9174900548006 0.948667882804606 GO:0015616 DNA translocase activity 2/503 152/18639 0.0131578947368421 0.487574552683897 0.919301474485568 0.948667882804606 GO:0140674 ATP-dependent histone chaperone activity 2/503 152/18639 0.0131578947368421 0.487574552683897 0.919301474485568 0.948667882804606 GO:0052689 carboxylic ester hydrolase activity 1/503 92/18639 0.0108695652173913 0.402778978304088 0.919790731918784 0.948667882804606 GO:0061775 cohesin loader activity 2/503 153/18639 0.0130718954248366 0.484387790901649 0.921075475531223 0.948722205493382 GO:0046873 metal ion transmembrane transporter activity 8/503 450/18639 0.0177777777777778 0.658767395626243 0.921982571742159 0.948722205493382 GO:0003730 mRNA 3'-UTR binding 4/503 262/18639 0.0152671755725191 0.56573535883933 0.925999921766133 0.951751947400417 GO:0005249 voltage-gated potassium channel activity 1/503 98/18639 0.0102040816326531 0.378119040856899 0.931990491077944 0.956219712872859 GO:0003689 DNA clamp loader activity 2/503 160/18639 0.0125 0.463195825049702 0.932502876702394 0.956219712872859 GO:0140713 histone chaperone activity 2/503 164/18639 0.0121951219512195 0.451898365902148 0.938311454951507 0.961064965983819 GO:0004722 protein serine/threonine phosphatase activity 1/503 103/18639 0.00970873786407767 0.359763747611419 0.940729410117825 0.962430203892169 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 2/503 167/18639 0.0119760479041916 0.443780431185343 0.94235351531556 0.962981069222237 GO:0003823 antigen binding 2/503 174/18639 0.0114942528735632 0.425927195448002 0.950828646565853 0.970523601270324 GO:0003735 structural constituent of ribosome 2/503 175/18639 0.0114285714285714 0.423493325759727 0.951937803742595 0.970538887264002 GO:0005261 monoatomic cation channel activity 5/503 341/18639 0.0146627565982405 0.543338211201996 0.955000616752611 0.97254368204313 GO:0015294 solute:monoatomic cation symporter activity 1/503 116/18639 0.00862068965517241 0.319445396586001 0.958555800520575 0.975044719107511 GO:0004519 endonuclease activity 1/503 127/18639 0.0078740157480315 0.291776897669103 0.969387006088969 0.984932731272526 GO:0008168 methyltransferase activity 2/503 204/18639 0.00980392156862745 0.363290843176237 0.975437579531962 0.98967676310058 GO:0140101 catalytic activity, acting on a tRNA 1/503 139/18639 0.00719424460431655 0.266587525208462 0.978006334388205 0.98967676310058 GO:0004518 nuclease activity 2/503 209/18639 0.00956937799043062 0.354599674679198 0.978159445417495 0.98967676310058 GO:0022843 voltage-gated monoatomic cation channel activity 1/503 143/18639 0.00699300699300699 0.259130531496337 0.980302675773579 0.98967676310058 GO:0016741 transferase activity, transferring one-carbon groups 2/503 215/18639 0.00930232558139535 0.344703869804429 0.981041893192282 0.98967676310058 GO:0016755 aminoacyltransferase activity 7/503 496/18639 0.0141129032258065 0.522963028281921 0.981744301694434 0.98967676310058 GO:0015293 symporter activity 1/503 146/18639 0.00684931506849315 0.253805931534083 0.981866461700688 0.98967676310058 GO:0004842 ubiquitin-protein transferase activity 6/503 449/18639 0.0133630289532294 0.495175937692332 0.983201338215106 0.989897374570714 GO:0061630 ubiquitin protein ligase activity 4/503 353/18639 0.0113314447592068 0.419894232339673 0.986949088322022 0.992544037802306 GO:0019787 ubiquitin-like protein transferase activity 6/503 479/18639 0.0125260960334029 0.464162830947509 0.990211549948963 0.994494115280192 GO:0061659 ubiquitin-like protein ligase activity 4/503 372/18639 0.010752688172043 0.398448021548131 0.991130550065039 0.994494115280192 GO:0008234 cysteine-type peptidase activity 1/503 187/18639 0.0053475935828877 0.198158641732493 0.994153191516676 0.99639986539581 GO:0140098 catalytic activity, acting on RNA 3/503 387/18639 0.00775193798449612 0.287253224837024 0.998380688217092 0.999507528722981 GO:0045182 translation regulator activity 1/503 356/18639 0.00280898876404494 0.104088949449371 0.999946425465653 0.999946425465653