category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	15/226	142/9376	4.38240059827995	FOS/DUSP1/PIK3CB/CALM1/ACTG1/SDC1/BMPR2/MGST3/MAPK10/PIK3R1/TRPV4/MAP3K5/RAC1/GSTP1/TXN2	6.38268762673853
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	12/226	119/9376	4.18353536104707	FOS/PIK3CB/JUNB/MMP14/MAPK10/PIK3R1/MAP3K8/NFKBIA/MAP3K5/ATF6B/BCL3/CXCL1	5.49259197092616
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	15/226	204/9376	3.05049453409682	HSPG2/PIK3CB/TIMP3/EZR/ACTG1/SOS2/SDC1/CD63/PIK3R1/BRAF/FGFR1/HPSE/HPSE2/RAC1/CTTN	4.65340644889638
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	12/226	139/9376	3.58158782708347	FOS/KRT19/PIK3CB/CALM1/SOS2/HSPA1B/PIK3R1/KRT10/HSPA8/ESR2/KRT23/ATF6B	4.81901350775062
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	15/226	216/9376	2.88102261553589	FOS/PIK3CB/CALM1/ABCA1/HSPA1B/MAPK10/PIK3R1/ABCG1/HSPA8/NFKBIA/LDLR/MAP3K5/DDIT3/RAC1/CXCL1	4.39544111832587
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	9/226	87/9376	4.29173024107415	FOS/GADD45G/PIK3CB/SOS2/MAPK10/PIK3R1/BRAF/RAC1/GADD45B	4.84762138823339
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	8/226	70/9376	4.74134007585335	PIK3CB/EPAS1/SOS2/PIK3R1/BRAF/SLC2A1/RAC1/EGLN3	4.93769195801324
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	18/226	300/9376	2.48920353982301	FLT1/FOS/GADD45G/DUSP1/HSPB1/SOS2/HSPA1B/RASGRP1/MAPK10/BRAF/MAP3K8/FGFR1/HSPA8/MAP3K5/DDIT3/MAP3K13/RAC1/GADD45B	4.1199956202258
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	11/226	137/9376	3.33105096569989	FOS/GADD45G/PIK3CB/ACTG1/CSF2RB/MAPK10/PIK3R1/NFKBIA/MAP3K5/DDIT3/GADD45B	4.31945426237095
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	6/226	42/9376	5.92667509481669	KYNU/KMO/KYAT1/GCDH/MAOA/AOC1	5.02891135051831
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	8/226	77/9376	4.31030915986668	GADD45G/PIK3CB/SOS2/HDAC2/PIK3R1/BRAF/NFKBIA/GADD45B	4.58379414174667
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	8/226	78/9376	4.25504878602224	PIK3CB/ACTG1/DNM2/PIK3R1/ACTR3B/RAC1/CTTN/ELMO3	4.53669249724272
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	9/226	98/9376	3.81000541809644	PIK3CB/CALM1/IMPA2/INPP5B/DGKG/PIK3R1/IPMK/IP6K2/MTMR4	4.39463005745761
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	15/226	248/9376	2.50927776191836	FOS/SNX9/PIK3CB/ACTG1/RHOB/DNM2/MAPK10/GSDMD/DYNC2H1/NFKBIA/ACTR3B/STX10/GAPDH/RAC1/TXN2	3.78561556440614
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	14/226	227/9376	2.55865268410588	FOS/PIK3CB/PRKD3/SLC26A6/SOS2/MGST3/MAPK10/PIK3R1/BRAF/NFKBIA/UQCRC1/MAP3K5/RAC1/SLC25A5	3.73598201870926
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	9/226	110/9376	3.39436846339501	FLT1/SERPINE1/PIK3CB/EPAS1/PIK3R1/PFKL/GAPDH/SLC2A1/EGLN3	3.96981701744751
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	10/226	133/9376	3.11930268148247	GADD45G/PIK3CB/SGK1/SOS2/MAPK10/PIK3R1/BRAF/BCL6/CSNK1E/GADD45B	3.86849145890058
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	11/226	157/9376	2.90671326306296	LEP/FOS/PIK3CB/MAPK10/PIK3R1/SREBF1/MLX/UQCRC1/MAP3K5/DDIT3/RAC1	3.78636622046457
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	8/226	91/9376	3.64718467373335	FOS/PIK3CB/PIK3AP1/SOS2/PIK3R1/BLNK/NFKBIA/RAC1	3.98789112182982
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	7/226	71/9376	4.09024055839461	CGA/FOS/PIK3CB/SOS2/MAPK10/PIK3R1/ESR2	4.10764198832255
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	9/226	115/9376	3.2467872258561	FOS/GCM1/SGK1/MMP14/BRAF/WNK2/FGFR1/ATF6B/MMP24	3.80987945562235
Human Diseases	Cancer: specific types	hsa05214	Glioma	7/226	76/9376	3.82114578481602	GADD45G/PIK3CB/CALM1/SOS2/PIK3R1/BRAF/GADD45B	3.8807901724548
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	9/226	120/9376	3.11150442477876	PIK3CB/CALM1/SOS2/MAPK10/PIK3R1/BRAF/NFKBIA/MAP3K5/RAC1	3.65847638988958
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	7/226	77/9376	3.77152051488335	GADD45G/PIK3CB/MAPK10/PIK3R1/BRAF/RAC1/GADD45B	3.83773203236541
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	7/226	78/9376	3.72316768776946	PIK3CB/PIP5KL1/IMPA2/INPP5B/IPMK/IP6K2/MTMR4	3.79538840428093
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	9/226	122/9376	3.06049615552009	FOS/PIK3CB/SOS2/PPP2R2B/RASGRP1/MAPK10/PIK3R1/MAP3K8/NFKBIA	3.60011428052789
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	6/226	59/9376	4.21898905054747	GADD45G/PIK3CB/SOS2/PIK3R1/BRAF/GADD45B	3.89795452567635
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	10/226	148/9376	2.80315713944033	FOS/GADD45G/PIK3CB/HES1/SOS2/PIK3R1/BRAF/FGFR1/ESR2/GADD45B	3.47488111878866
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	9/226	125/9376	2.98704424778761	PIK3CB/ACER2/PPP2R2B/MAPK10/PIK3R1/DEGS1/MAP3K5/SPTLC2/RAC1	3.5147748886303
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	11/226	174/9376	2.62272403621198	MAN1C1/DERL3/PPP1R15A/CALR/HSPA1B/MAPK10/HSPA8/MAP3K5/DDIT3/ATF6B/DNAJB1	3.3955293560328
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	8/226	103/9376	3.22226995446344	FOS/SERPINE1/PIK3CB/CALR/PPP2R2B/MAPK10/PIK3R1/NFKBIA	3.56397466191207
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	10/226	163/9376	2.54519789347956	FOS/HSPG2/PIK3CB/SOS2/MAPK10/PIK3R1/BRAF/DDB1/NFKBIA/ATF6B	3.12756745137141
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	9/226	138/9376	2.70565602154675	FOS/PIK3CB/ACTG1/MAPK10/PIK3R1/ARHGEF28/NFKBIA/ACTR3B/RAC1	3.17227863860801
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	6/226	69/9376	3.60754136206233	FOS/FOSB/CALM1/HDAC2/MAOA/ATF6B	3.41649040437133
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	4/226	32/9376	5.1858407079646	GALE/UGP2/PFKL/AKR1B1	3.72752514918948
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	9/226	142/9376	2.62944035896797	FOS/FOSB/PIK3CB/JUNB/MAPK10/PIK3R1/BLNK/NFKBIA/RAC1	3.07480102238099
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	10/226	170/9376	2.44039562727746	GADD45G/PIK3CB/ACTG1/SOS2/MGST3/PIK3R1/BRAF/SMARCA2/GADD45B/GSTP1	2.97851698103974
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	5/226	52/9376	3.98910823689585	CGA/CYP11A1/SCARB1/HSD3B1/LDLR	3.39681184654592
Human Diseases	Cancer: specific types	hsa05218	Melanoma	6/226	73/9376	3.40986786277124	GADD45G/PIK3CB/PIK3R1/BRAF/FGFR1/GADD45B	3.24842212966477
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	6/226	73/9376	3.40986786277124	GADD45G/PIK3CB/SOS2/PIK3R1/BRAF/GADD45B	3.24842212966477
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	12/226	226/9376	2.20283499099381	CGA/FOS/PIK3CB/CRH/CALM1/MAPK10/PIK3R1/BRAF/RAPGEF3/NFKBIA/RAC1/CHRM2	2.87659708953043
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	6/226	75/9376	3.31893805309735	PIK3CB/MGST3/PIK3R1/REV3L/MAP3K5/GSTP1	3.16872293696753
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	7/226	98/9376	2.96333754740834	PRKD3/CALM1/CYP11A1/SCARB1/HSD3B1/LDLR/ATF6B	3.07050731760535
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	7/226	99/9376	2.93340484490927	FOS/PIK3CB/SOS2/MAPK10/PIK3R1/BRAF/ESR2	3.03924654940141
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	7/226	99/9376	2.93340484490927	FOS/PIK3CB/SOS2/DGKG/MAPK10/PIK3R1/RAC1	3.03924654940141
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	3/226	19/9376	6.55053563111318	HEXB/HPSE/HPSE2	3.80603424351246
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	12/226	232/9376	2.14586512053708	PIK3CB/EZR/ACTG1/ARHGEF4/SOS2/GSN/PIK3R1/BRAF/FGFR1/ACTR3B/RAC1/CHRM2	2.77740168375142
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	11/226	205/9376	2.22611698683358	GADD45G/PIK3CB/HES1/HDAC2/CALR/MAPK10/PIK3R1/BLNK/NFKBIA/RAC1/GADD45B	2.78952208296739
NA	NA	hsa04518	Integrin signaling	9/226	154/9376	2.42454890242501	FLT1/FLNB/PIK3CB/ACTG1/LAMA5/NPNT/PIK3R1/LIMS2/RAC1	2.80126680338892
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	9/226	157/9376	2.37821994250606	GADD45G/SERPINE1/PIK3CB/CALM1/PIK3R1/RAD9A/TRPV4/SLC25A5/GADD45B	2.7368800205924
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	7/226	106/9376	2.73968943062281	PIK3CB/SOS2/PIK3R1/BRAF/FGFR1/NFKBIA/GSTP1	2.83083203245242
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	7/226	109/9376	2.66428513436714	FOS/PIK3CB/MAPK10/PIK3R1/MAP3K8/NFKBIA/RAC1	2.74663349673604
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	7/226	109/9376	2.66428513436714	PIK3CB/MAPK10/PIK3R1/SREBF1/MLX/NFKBIA/SLC2A1	2.74663349673604
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	5/226	62/9376	3.34570368255781	PIK3CB/HDAC2/HSPA1B/PIK3R1/HSPA8	2.91226028931195
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	5/226	65/9376	3.19128658951668	CYP11A1/SCARB1/HSD3B1/LDLR/ATF6B	2.78603781377524
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	9/226	170/9376	2.19635606454971	EZR/ACTG1/PPP2R2B/MAPK10/MYL6/ACTR3B/MAP3K5/RAC1/CTTN	2.47388063817331
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	8/226	144/9376	2.30481809242871	INHBA/PIK3CB/BMPR2/KLF4/PIK3R1/DLX5/LIFR/FGFR1	2.47977700704085
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	6/226	93/9376	2.67656294604625	GADD45G/PIK3CB/LAMA5/PIK3R1/NFKBIA/GADD45B	2.55356239047058
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	10/226	203/9376	2.04368106717817	FLT1/FLNB/PIK3CB/ACTG1/LAMA5/SOS2/MAPK10/PIK3R1/BRAF/RAC1	2.36259585773809
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	5/226	69/9376	3.00628446838528	PIK3CB/SOS2/MAPK10/PIK3R1/RAC1	2.62870293618517
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	7/226	122/9376	2.38038589873785	PIK3CB/ACTG1/HDAC2/PIK3R1/MED12L/PFKL/SLC2A1	2.41182055757396
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	7/226	122/9376	2.38038589873785	FOS/PIK3CB/JUNB/SOS2/MAPK10/PIK3R1/ATF6B	2.41182055757396
NA	NA	hsa03272	Virion - Hepatitis viruses	4/226	48/9376	3.45722713864307	HSPG2/SCARB1/CD63/LDLR	2.68226056092726
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	5/226	71/9376	2.9216003988533	MAPK10/NFKBIA/ATP6V1C2/RAC1/CXCL1	2.55424985011772
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	5/226	71/9376	2.9216003988533	PIK3CB/PIK3R1/FGFR1/PFKL/SLC2A1	2.55424985011772
NA	NA	hsa04517	IgSF CAM signaling	13/226	299/9376	1.80377068103117	NECTIN4/PIK3CB/NLGN1/EZR/ACTG1/LRFN5/MAPK10/PIK3R1/FGFR1/MYL6/ACTR3B/RAC1/GLDN	2.21986159482614
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	6/226	98/9376	2.54000361206429	PIK3CB/GSN/DNM2/PIK3R1/ACTR3B/RAC1	2.40844594767922
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	10/226	212/9376	1.95692102187343	FLT1/PIK3CB/PRKD3/CALM1/ACTG1/PIK3R1/BRAF/RAPGEF3/FGFR1/RAC1	2.21478103649976
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	8/226	156/9376	2.12752439301112	PIK3CB/SCARB1/SOS2/PPP2R2B/PIK3R1/BRAF/NFKBIA/LDLR	2.2317836705616
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	4/226	52/9376	3.19128658951668	SCARB1/ABCA1/LDLR/LPL	2.49017019677325
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	10/226	217/9376	1.91183067574732	FOS/PIK3CB/PAQR7/SOS2/KLF4/MGST3/PIK3R1/ESR2/BCL6/ATF6B	2.13574474656724
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	8/226	158/9376	2.10059370449199	PIK3CB/SGK1/FNIP2/SOS2/CASTOR2/PIK3R1/BRAF/ATP6V1C2	2.19263593063609
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	7/226	130/9376	2.23390061266167	FOS/PIK3CB/SOS2/MAPK10/PIK3R1/NFKBIA/ATF6B	2.22640527455186
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	6/226	103/9376	2.41670246584758	PIK3CB/LAMA5/HSPB1/SERPINB9/PIK3R1/CXCL1	2.27204245893169
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	6/226	105/9376	2.37067003792668	PIK3CB/CALM1/MAPK10/PIK3R1/NFKBIA/BCL3	2.21969645877567
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	4/226	55/9376	3.01721641190668	ACER2/HEXB/DEGS1/SPTLC2	2.35793535528417
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	9/226	193/9376	1.93461415012151	PIK3CB/SOS2/PIK3R1/BRAF/DOCK2/NFKBIA/RAC1/CXCL1/GRK3	2.06180707271334
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	4/226	56/9376	2.96333754740834	HSPA1B/HSPA8/NFKBIA/CXCL1	2.31584954159038
Human Diseases	Infectious disease: viral	hsa05162	Measles	7/226	136/9376	2.13534617386778	FOS/PIK3CB/HSPA1B/MAPK10/PIK3R1/HSPA8/NFKBIA	2.09599904306115
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	9/226	196/9376	1.90500270904822	FOS/PIK3CB/CALM1/UBC/MAPK10/PIK3R1/NFKBIA/RAC1/CXCL1	2.0122682972183
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	7/226	138/9376	2.10439912786969	PIK3CB/CALM1/SOS2/MAPK10/PIK3R1/BRAF/SREBF1	2.05402596864829
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/226	15/9376	5.53156342182891	HEXB/ST3GAL1	2.76033555978204
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	9/226	200/9376	1.86690265486726	FOS/EZR/ACTG1/MAPK10/NFKBIA/ACTR3B/GAPDH/RAC1/CTTN	1.94754696335818
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	6/226	112/9376	2.22250316055626	LAMA5/HSPA1B/MAPK10/HSPA8/NFKBIA/LDLR	2.04545080828049
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/226	36/9376	3.45722713864307	UGP2/DCXR/AKR1B1	2.32141307502352
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/226	16/9376	5.1858407079646	HEXB/ST3GAL1	2.6335045616026
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	4/226	60/9376	2.76578171091445	PIK3CB/HSPB1/PIK3R1/RAC1	2.15638950907994
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	5/226	86/9376	2.41201893393702	PIK3CB/SOS2/MAPK10/PIK3R1/BRAF	2.0673366295301
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	3/226	37/9376	3.36378856732839	GADD45G/BRAF/GADD45B	2.26406354993788
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	6/226	116/9376	2.14586512053708	PIK3CB/EZR/ACTG1/PIK3R1/RAPGEF3/RAC1	1.9515797897129
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	4/226	62/9376	2.67656294604625	HES1/HDAC2/MAML2/TLE6	2.08150233407924
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	3/226	38/9376	3.27526781555659	GALE/HEXB/UGP2	2.20864897400762
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	3/226	38/9376	3.27526781555659	QPRT/NT5E/SIRT7	2.20864897400762
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	3/226	38/9376	3.27526781555659	PIK3CB/SGK1/PIK3R1	2.20864897400762
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	5/226	90/9376	2.30481809242871	FOS/PIK3CB/RASGRP1/PIK3R1/NFKBIA	1.95472737792062
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	7/226	150/9376	1.93604719764012	GADD45G/PIK3CB/SOS2/PIK3R1/BRAF/ABCB1/GADD45B	1.81620958173286
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	4/226	65/9376	2.55302927161334	CGA/PIK3CB/PIK3R1/ESR2	1.97454696127581
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	5/226	93/9376	2.23046912170521	CGA/CALM1/MMP14/SOS2/MAPK10	1.87411971571458
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	9/226	214/9376	1.74476883632454	FOS/PIK3CB/CALM1/CALR/MAPK10/PIK3R1/DDB1/NFKBIA/RAC1	1.73205847417966
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	6/226	122/9376	2.04033077034673	LEP/PIK3CB/PPP2R2B/PIK3R1/SREBF1/PFKL	1.81767369609699
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	5/226	94/9376	2.20674072679345	FOS/FOSB/MAPK10/NFKBIA/CXCL1	1.84793387053546
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	7/226	154/9376	1.88576025744167	RDH13/KYNU/KMO/MTHFD1L/QPRT/UGP2/CTPS1	1.74178001240165
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	10/226	250/9376	1.65946902654867	PIP5KL1/RNF103-CHMP3/HSPA1B/DAB2/DNM2/HSPA8/LDLR/ACTR3B/RAB11A/GRK3	1.66093824599518
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	7/226	155/9376	1.87359406223237	CRH/CYP11A1/SCARB1/HSD3B1/BRAF/LDLR/ATF6B	1.72351799554724
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	4/226	68/9376	2.44039562727746	PIK3CB/SOS2/PIK3R1/BRAF	1.87342958407297
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	7/226	157/9376	1.84972662194916	SGK1/ABCA1/CALR/P2RY6/SLC2A1/RAC1/ATP11A	1.68739382072023
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	4/226	70/9376	2.37067003792668	LEP/MAPK10/NFKBIA/SLC2A1	1.80896317526456
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	3/226	44/9376	2.82864038616251	AQP3/DYNC2H1/RAB11A	1.91071798280519
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	5/226	99/9376	2.09528917493519	PIK3CB/CALM1/MAPK10/PIK3R1/TRPV4	1.72175726893594
Human Diseases	Substance dependence	hsa05034	Alcoholism	8/226	191/9376	1.73766390214521	FOSB/CRH/CALM1/SOS2/HDAC2/BRAF/MAOA/ATF6B	1.61869470345817
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	9/226	224/9376	1.66687737041719	FOS/PIK3CB/CALR/MAPK10/PIK3R1/NFKBIA/SLC2A1/ATF6B/SLC25A5	1.58760074727427
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	3/226	45/9376	2.76578171091445	ABCA1/ABCB1/ABCG1	1.86598645625133
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	5/226	101/9376	2.053798300184	SERPINE1/PIK3CB/MAPK10/PIK3R1/RAC1	1.67336442637265
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/226	22/9376	3.77152051488335	MAOA/AOC1	2.04531435272216
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	6/226	133/9376	1.87158160888948	FOS/CALM1/PPP2R2B/MAPK10/MAOA/ATF6B	1.59095066466167
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	3/226	47/9376	2.64808887215214	PIK3CB/MAPK10/PIK3R1	1.7800873757607
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/226	23/9376	3.60754136206233	PREP/MME	1.96765506449633
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	5/226	105/9376	1.9755583649389	GADD45G/BLNK/NFKBIA/GADD45B/CXCL1	1.57984298778382
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	7/226	168/9376	1.72861356932153	LEP/PIK3CB/CSF2RB/SOS2/FHL1/PIK3R1/LIFR	1.49760937939
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	10/226	268/9376	1.54801215163122	DUSP1/CALM1/UBC/MAPK10/MAOA/UQCRC1/MAP3K5/DDIT3/SLC25A5/TXN2	1.43045890419328
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	3/226	49/9376	2.54000361206429	FOSB/MAOA/ATF6B	1.6985490855132
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	7/226	169/9376	1.71838508666283	PIK3CB/UBC/MAPK10/PIK3R1/ATG4B/ATG16L2/MTMR4	1.48105402067253
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	3/226	50/9376	2.48920353982301	SAT1/MAOA/AOC1	1.65928377755782
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	9/226	238/9376	1.56882576039265	FLT1/PIK3CB/CALM1/SOS2/RASGRP1/MAPK10/PIK3R1/FGFR1/RAC1	1.39691978505143
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	8/226	205/9376	1.61899417224261	PIK3CB/HDAC2/GSN/PIK3R1/DDB1/NFKBIA/ATF6B/RAC1	1.40826522366191
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	8/226	205/9376	1.61899417224261	PIK3CB/MAPK10/PIK3R1/GAPDH/SLC2A1/UQCRC1/RAC1/SLC25A5	1.40826522366191
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	7/226	173/9376	1.67865363957236	PIK3CB/ACTG1/PIK3R1/NFKBIA/RAB11A/SLC25A5/DNAJB1	1.41591060250864
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	5/226	110/9376	1.88576025744167	SPDYE2/PIK3CB/MAPK10/PIK3R1/BRAF	1.46857352873117
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	4/226	80/9376	2.07433628318584	PIK3CB/SOS2/PIK3R1/BRAF	1.51658407023309
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	10/226	275/9376	1.50860820595334	PIK3CB/HSPA1B/MAPK10/PIK3R1/HSPA8/UQCRC1/DDIT3/ATF6B/RAC1/SLC25A5	1.34534746063556
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	6/226	144/9376	1.72861356932153	PIK3CB/MAPK10/PIK3R1/NOP56/MAP3K5/SLC25A5	1.38471346060081
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	13/226	388/9376	1.39001915883587	PIK3CB/CALM1/MME/MAPK10/PIK3R1/BRAF/LPL/GAPDH/UQCRC1/MAP3K5/DDIT3/CSNK1E/SLC25A5	1.23310364916815
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	6/226	149/9376	1.67060640256578	PIK3CB/SOS2/DGKG/DNM2/PIK3R1/RAPGEF3	1.29676081931986
NA	NA	hsa04382	Cornified envelope formation	8/226	217/9376	1.52946454059785	KRT19/LAMA5/S100A6/KRT7/PPP2R2B/KRT10/KRT23/SPTLC2	1.24014374724641
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/226	29/9376	2.86115349404944	LIMD1/CSNK1E	1.57751820680084
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	9/226	253/9376	1.47581237538914	PIK3CB/ACTG1/UBC/MAPK10/PIK3R1/NFKBIA/ACTR3B/RAC1/CTTN	1.20574776977248
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	12/226	362/9376	1.37525057448785	FLT1/PIK3CB/LAMA5/SGK1/PIK3AP1/SOS2/PPP2R2B/PIK3R1/FGFR1/ATF6B/RAC1/CHRM2	1.14431656540029
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	4/226	89/9376	1.86457193994233	HSPG2/LAMA5/SDC1/NPNT	1.28791656034471
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	3/226	59/9376	2.10949452527374	UCK2/NT5E/CTPS1	1.34351473027482
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	3/226	59/9376	2.10949452527374	PRDX6/MGST3/GSTP1	1.34351473027482
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	3/226	59/9376	2.10949452527374	CGA/PIK3CB/PIK3R1	1.34351473027482
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	6/226	155/9376	1.60593776762775	ACTG1/SCARB1/CALR/DYNC2H1/ATP6V1C2/RAC1	1.19545758360518
Organismal Systems	Digestive system	hsa04976	Bile secretion	4/226	90/9376	1.84385447394297	SCARB1/ABCB1/LDLR/SLC2A1	1.26416506083759
NA	NA	hsa04519	Cadherin signaling	13/226	404/9376	1.3349688951196	KRT19/ACTG1/LIMD1/KRT7/MAPK10/KRT10/FGFR1/NFKBIA/ACTR3B/FMN1/KRT23/TMC5/RAC1	1.0816327826219
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	6/226	157/9376	1.58547996167071	SERPINE1/ACTG1/LIMD1/PPP2R2B/BMPR2/CSNK1E	1.16265072078415
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	8/226	227/9376	1.4620872480605	PIK3CB/CALM1/SOS2/CALR/PIK3R1/NFKBIA/ATF6B/RAC1	1.10759097740829
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	4/226	93/9376	1.78437529736416	NECTIN4/ACTG1/FGFR1/RAC1	1.19467704095857
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	4/226	93/9376	1.78437529736416	FOS/MAML2/MAPK10/NFKBIA	1.19467704095857
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	2/226	33/9376	2.51434700992223	GPT2/OGDH	1.36952041533036
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	7/226	195/9376	1.48926707510778	PIK3CB/ACTG1/HDAC2/PIK3R1/GSDMD/RAC1/SLC25A5	1.08504465995451
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	4/226	95/9376	1.74680950163018	FLT1/FOS/ATP6V1C2/CXCL1	1.14975038024011
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/226	34/9376	2.44039562727746	BHLHE40/CSNK1E	1.32230193073851
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	8/226	233/9376	1.4244369326598	HSPG2/ACTG1/SDC3/SDC1/COL27A1/FHL1/FMNL1/DMD	1.03104133958847
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/226	35/9376	2.37067003792668	PFKL/AKR1B1	1.27673147863096
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	3/226	65/9376	1.91477195371001	DGKG/LPL/AKR1B1	1.16305610877638
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	7/226	201/9376	1.44481134152248	FLT1/GADD45G/HDAC2/BCL6/NFKBIZ/DDIT3/GADD45B	1.00184412345318
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3/226	66/9376	1.88576025744167	CYP11A1/HSD3B1/STS	1.13486088712329
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	5/226	133/9376	1.55965134074123	PIK3CB/SOS2/PIK3R1/BRAF/RAC1	1.02156546610194
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	3/226	67/9376	1.85761458195747	CALM1/BRAF/RAPGEF3	1.10715226695954
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/226	37/9376	2.24252571155226	MAOA/FAHD1	1.19010524556585
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	2/226	37/9376	2.24252571155226	GALE/UGP2	1.19010524556585
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	3/226	70/9376	1.77800252844501	ACTG1/RAC1/DMD	1.0267809795774
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/226	12/9376	3.45722713864307	NECTIN4	1.33854980292083
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3/226	73/9376	1.70493393138562	MGST3/MAOA/GSTP1	0.950227611248081
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	5/226	144/9376	1.44051130776794	MAPK10/SREBF1/NFKBIA/MAP3K5/CXCL1	0.837181687380785
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	6/226	180/9376	1.38289085545723	PIK3CB/CALR/PILRB/PIK3R1/SRSF7/NFKBIA	0.81515665076282
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	4/226	109/9376	1.52244864820979	FOS/EBI3/MAPK10/NFKBIA	0.862217013098024
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	3/226	75/9376	1.65946902654867	GPT2/PFKL/GAPDH	0.901134304926043
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	3/226	75/9376	1.65946902654867	GADD45G/SERPINE1/GADD45B	0.901134304926043
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	4/226	110/9376	1.50860820595334	INHBA/GREM2/HDAC2/BMPR2	0.843262656552085
NA	NA	hsa04081	Hormone signaling	7/226	219/9376	1.32605972441104	CGA/LEP/PIK3CB/CRH/PIK3R1/RAPGEF3/ESR2	0.767311872826483
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	3/226	76/9376	1.6376339077783	PLIN2/UBC/LPL	0.877134182943804
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	3/226	76/9376	1.6376339077783	EZR/CALM1/ACTG1	0.877134182943804
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/226	43/9376	1.92961514714962	SCARB1/ABCA1	0.960187608812806
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	6/226	184/9376	1.35282801077337	PIK3CB/BMPR2/PIK3R1/SEMA4B/SEMA4C/RAC1	0.75961978982782
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	2/226	44/9376	1.88576025744167	MAN1C1/HEXB	0.925517157531244
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/226	14/9376	2.96333754740834	ST3GAL1	1.15532449801786
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	3/226	78/9376	1.59564329475834	FOS/CALM1/MAPK10	0.83017203243375
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	9/226	298/9376	1.25295480192433	LEP/EBI3/INHBA/CSF2RB/GDF15/BMPR2/INHA/LIFR/CXCL1	0.697405361402477
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	6/226	187/9376	1.33112488760589	MAPK10/GSDMD/NFKBIA/CARD16/CXCL1/TXN2	0.718799575799744
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	4/226	115/9376	1.44301654482493	FOS/PIK3CB/PIK3R1/CHRM2	0.751223619756067
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	4/226	115/9376	1.44301654482493	DUSP1/BRAF/RAPGEF3/MAOA	0.751223619756067
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	4/226	116/9376	1.43057674702472	GPT2/OGDH/PFKL/GAPDH	0.733336640022609
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	3/226	82/9376	1.51780703647744	MGST3/UCK2/GSTP1	0.740121210779579
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	3/226	82/9376	1.51780703647744	CALR/HSPA1B/HSPA8	0.740121210779579
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/226	48/9376	1.72861356932153	PIK3CB/PIK3R1	0.795340166325371
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/226	16/9376	2.5929203539823	MAOA	1.00217932576843
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	3/226	85/9376	1.46423737636648	UCK2/NT5E/CTPS1	0.675690241404301
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/226	17/9376	2.44039562727746	CDO1	0.934159085554205
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/226	17/9376	2.44039562727746	KYAT1	0.934159085554205
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	2/226	50/9376	1.65946902654867	SDC1/HBA1	0.734786231896889
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	2/226	51/9376	1.62693041818497	ACTG1/ATP6V1C2	0.705519985282857
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/226	18/9376	2.30481809242871	HEXB	0.870811213416968
Organismal Systems	Immune system	hsa04611	Platelet activation	4/226	126/9376	1.31703890995926	PIK3CB/ACTG1/RASGRP1/PIK3R1	0.563062083574506
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	2/226	53/9376	1.56553681749875	DNM2/RAB11A	0.648858931417215
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	3/226	90/9376	1.38289085545723	PIK3CB/PIK3R1/ATF6B	0.573602743754552
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/226	19/9376	2.18351187703773	OGDH	0.811540909017803
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	2/226	54/9376	1.53654539495247	KYAT1/CDO1	0.621409821561948
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	2/226	54/9376	1.53654539495247	HES1/REV3L	0.621409821561948
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/226	20/9376	2.07433628318584	FDFT1	0.755856662050522
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/226	20/9376	2.07433628318584	UGP2	0.755856662050522
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	2/226	56/9376	1.48166877370417	MAN1C1/MGAT3	0.568151110976134
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	2/226	56/9376	1.48166877370417	CSNK1E/GRK3	0.568151110976134
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	9/226	333/9376	1.12126285577613	PIK3CB/LAMA5/HES1/SOS2/HDAC2/MAML2/PPP2R2B/PIK3R1/ATP6V1C2	0.354097576066159
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/226	60/9376	1.38289085545723	CRH/BRAF	0.467589973736345
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	3/226	99/9376	1.25717350496112	KRT19/KRT10/KRT23	0.404267988470473
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/226	23/9376	1.80377068103117	GPT2	0.606526697614406
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/226	24/9376	1.72861356932153	EXT1	0.561668331241315
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	4/226	142/9376	1.16864015954132	RHOBTB1/UBC/DDB1/MID1	0.318228852083032
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	2/226	63/9376	1.31703890995926	GCDH/KMT2E	0.396796059057794
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	2/226	63/9376	1.31703890995926	CCNH/DDB1	0.396796059057794
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/226	63/9376	1.31703890995926	GADD45G/GADD45B	0.396796059057794
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	3/226	105/9376	1.18533501896334	UBC/MAPK10/MTX1	0.300136045800141
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/226	26/9376	1.59564329475834	HES1	0.47796537515613
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/226	26/9376	1.59564329475834	SCARB1	0.47796537515613
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	3/226	107/9376	1.16317922421636	CALM1/PFKL/SLC2A1	0.266790046412006
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	2/226	67/9376	1.23840972130498	PFKL/GAPDH	0.307779122418291
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/226	27/9376	1.53654539495247	TECR	0.438768139806514
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/226	28/9376	1.48166877370417	TECR	0.401141382315649
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/226	28/9376	1.48166877370417	AKR1B1	0.401141382315649
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/226	28/9376	1.48166877370417	ATP6V1C2	0.401141382315649
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	6/226	235/9376	1.05923554886085	ACTG1/SOS2/FGFR1/SMARCA2/UQCRC1/MAP3K5	0.144526938870975
Cellular Processes	Cell motility	hsa04814	Motor proteins	5/226	194/9376	1.06924550679683	MYO7B/ACTG1/KIF2A/MYL6/DYNC2H1	0.153162740914728
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/226	70/9376	1.18533501896334	MGST3/GSTP1	0.244598783890228
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/226	29/9376	1.43057674702472	CALM1	0.364957893063779
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	4/226	154/9376	1.07757728996667	CALM1/PPP2R2B/RAPGEF3/ATF6B	0.152549825920736
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	4/226	154/9376	1.07757728996667	FOS/CALM1/ACTG1/MYL6	0.152549825920736
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	6/226	238/9376	1.04588384026177	FOS/PIK3CB/RPL10A/MAPK10/PIK3R1/NFKBIA	0.112681331857333
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/226	30/9376	1.38289085545723	OGDH	0.330104955542659
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	8/226	323/9376	1.02753500095893	PIK3CB/TIMP3/EZR/SOS2/HDAC2/BMPR2/PIK3R1/ABCB1	0.0791442572432429
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	2/226	72/9376	1.15240904621436	MAPK10/NFKBIA	0.204019394046789
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	2/226	73/9376	1.13662262092375	SERINC5/RANBP2	0.184162771775853
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/226	31/9376	1.33828147302312	PFKL	0.296482263643889
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	4/226	158/9376	1.050296852246	GADD45G/CCNH/HDAC2/GADD45B	0.100202904107441
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	3/226	116/9376	1.07293256026854	SHANK2/GRIK1/GRK3	0.124215065177465
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	3/226	117/9376	1.06376219650556	ACTG1/HDAC2/SMARCA2	0.109069536849273
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	4/226	160/9376	1.03716814159292	NLGN1/SDC3/SDC1/ALCAM	0.0745227574322655
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/226	32/9376	1.29646017699115	ATG4B	0.264000195555703
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/226	32/9376	1.29646017699115	MAPK10	0.264000195555703
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	2/226	75/9376	1.10631268436578	CGA/ATF6B	0.145271427578881
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	2/226	78/9376	1.06376219650556	FOS/NFKBIA	0.0888679394719557
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/226	79/9376	1.050296852246	MGST3/GSTP1	0.0705524739618425
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	2/226	79/9376	1.050296852246	DNM2/ATP6V1C2	0.0705524739618425
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/226	36/9376	1.15240904621436	UGP2	0.143985204733352
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/226	36/9376	1.15240904621436	ST3GAL1	0.143985204733352
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/226	37/9376	1.12126285577613	GPT2	0.116146941193818
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/226	37/9376	1.12126285577613	HBA1	0.116146941193818
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	2/226	83/9376	0.999680136475104	BCORL1/HDAC2	-0.000459997114282244
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	2/226	83/9376	0.999680136475104	GSDMD/NFKBIA	-0.000459997114282244
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/226	38/9376	1.09175593851886	BLNK	0.0890693649702153
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/226	39/9376	1.06376219650556	MTHFD1L	0.0627077479777528
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	2/226	86/9376	0.96480757357481	SLC2A1/ATF6B	-0.0515252242602603
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	2/226	86/9376	0.96480757357481	ACTG1/DMD	-0.0515252242602603
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	4/226	178/9376	0.932285969971164	MAPK10/CSNK1E/RAC1/TLE6	-0.143341277614919
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	2/226	88/9376	0.942880128720837	SERPINE1/PROCR	-0.0846051429371426
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	3/226	134/9376	0.928807290978734	CALM1/BRAF/MYL6	-0.130447045391328
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/226	41/9376	1.01187135765163	MAOA	0.0119719382257458
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	1/226	41/9376	1.01187135765163	RAD51B	0.0119719382257458
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	1/226	41/9376	1.01187135765163	BRAF	0.0119719382257458
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	1/226	42/9376	0.987779182469448	SAT1	-0.01247441871226
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/226	43/9376	0.96480757357481	GCDH	-0.0363498076393601
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	3/226	138/9376	0.901885340515583	ATP12A/UQCRC1/ATP6V1C2	-0.182479371271158
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/226	44/9376	0.942880128720837	CCNH	-0.0596836677427051
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	2/226	97/9376	0.85539640543746	FOS/CALM1	-0.224979879232767
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	2/226	99/9376	0.838115669974077	ACTG1/DMD	-0.254476651762262
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	2/226	101/9376	0.8215193200736	CALM1/ASIP	-0.283415925544283
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	2/226	102/9376	0.813465209092487	RAB11A/RAC1	-0.297684139017922
NA	NA	hsa04082	Neuroactive ligand signaling	4/226	199/9376	0.833904033441544	P2RY14/GRIK1/P2RY6/CHRM2	-0.372189887752748
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	2/226	103/9376	0.80556748861586	COL27A1/MME	-0.311821947029075
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	2/226	105/9376	0.790223345975558	ACTG1/DMD	-0.339717425191701
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	10/226	480/9376	0.864306784660767	CALM1/UBC/MAPK10/BRAF/UQCRC1/MAP3K5/DDIT3/CSNK1E/RAC1/SLC25A5	-0.479634788838515
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	1/226	54/9376	0.768272697476237	CGA	-0.268379195995294
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	5/226	254/9376	0.816667828025921	FLT1/CALM1/FGFR1/SLC25A5/CHRM2	-0.465521580581433
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/226	57/9376	0.727837292345909	TECR	-0.323899814769517
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	3/226	166/9376	0.749760102356328	CALM1/ATF6B/SLC25A5	-0.511222657261902
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	3/226	168/9376	0.740834386852086	RNF103-CHMP3/MAPK10/SLC25A5	-0.532695065543581
Organismal Systems	Digestive system	hsa04978	Mineral absorption	1/226	61/9376	0.680110256782243	SLC26A6	-0.393915539854555
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	7/226	368/9376	0.789149672951135	ACTG1/SRSF7/RANBP2/UQCRC1/MAP3K5/DDIT3/RAC1	-0.648504972293954
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	7/226	370/9376	0.784883999043291	CGA/LEP/P2RY14/CRH/GRIK1/P2RY6/CHRM2	-0.663493873600343
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/226	68/9376	0.610098906819365	RDH13	-0.507119175450182
Organismal Systems	Endocrine system	hsa04924	Renin secretion	1/226	69/9376	0.601256893677055	CALM1	-0.522446936559464
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	3/226	183/9376	0.680110256782243	NOP56/MDN1/NVL	-0.68679407662527
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	2/226	138/9376	0.601256893677055	SPDYE2/CALM1	-0.741605706251019
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	1/226	78/9376	0.53188109825278	PFKL	-0.652436153489838
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	2/226	140/9376	0.592667509481669	SERPINE1/CALM1	-0.763133325037475
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	5/226	308/9376	0.673485806229169	HDAC2/MAPK10/UQCRC1/MAP3K5/SLC25A5	-0.915695285759937
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	1/226	87/9376	0.476858915674906	UQCRC1	-0.77041243471105
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	1/226	89/9376	0.466142984985582	SOS2	-0.795264406266908
Human Diseases	Substance dependence	hsa05032	Morphine addiction	1/226	91/9376	0.455898084216668	GRK3	-0.819670505368569
Organismal Systems	Digestive system	hsa04970	Salivary secretion	1/226	93/9376	0.446093824341041	CALM1	-0.843650983309454
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	1/226	100/9376	0.414867256637168	CXCL1	-0.924492393358489
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	1/226	100/9376	0.414867256637168	MME	-0.924492393358489
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	1/226	103/9376	0.40278374430793	PPP2R2B	-0.957788048519265
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	1/226	104/9376	0.398910823689585	DGKG	-0.968719800393004
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	1/226	108/9376	0.384136348738119	RANBP2	-1.011655736234
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	2/226	181/9376	0.458416858162617	CALM1/MAPK10	-1.1562663017699
Genetic Information Processing	Transcription	hsa03040	Spliceosome	3/226	243/9376	0.512181798317491	HSPA1B/SRSF7/HSPA8	-1.21083152480584
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	3/226	250/9376	0.497840707964602	HEXB/CD63/ATP6V1C2	-1.26473805462628
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	1/226	128/9376	0.324115044247788	NT5E	-1.20999385514575
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	1/226	143/9376	0.290116962683334	SSB	-1.34435111125124
Genetic Information Processing	Translation	hsa03010	Ribosome	2/226	222/9376	0.37375428525871	RPL10A/MRPL55	-1.48403830575446
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	1/226	149/9376	0.27843440042763	MAPK10	-1.39530131909636
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/226	449/9376	0.184796105406311	CALM1/GRK3	-2.78205658947681