category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	11/413	62/9376	4.02780598297274	PIK3CB/HSPA1B/HDAC2/HSPA8/PIK3R1/CRYAB/HSPA1A/PRKAB2/ADCY5/FOXO1/KRAS	5.13440043542769
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	17/413	133/9376	2.90178230078829	GADD45G/PIK3CB/SOS2/SGK1/PIK3R1/BRAF/GADD45B/BCL6/MAPK10/CSNK1E/PDPK1/PRKAB2/PLK3/PRMT1/FOXO1/STAT3/KRAS	4.74148205288768
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	23/413	216/9376	2.41736167159896	FOS/PIK3CB/CALM1/HSPA1B/ABCA1/LDLR/HSPA8/PIK3R1/CXCL1/MAP3K5/NFKBIA/ABCG1/MAPK10/HSPA1A/PDPK1/RAC1/HSPA2/IRF3/DDIT3/NFATC3/NCF4/STAT3/KRAS	4.52369992696835
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	12/413	77/9376	3.53800194962423	GADD45G/PIK3CB/SOS2/HDAC2/PIK3R1/BRAF/GADD45B/NFKBIA/GAB2/STAT5A/RUNX1/KRAS	4.80013173041745
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	11/413	70/9376	3.56748529920443	PIK3CB/SOS2/EPAS1/PIK3R1/BRAF/EGLN3/SLC2A1/RAC1/PAK4/PAK6/KRAS	4.62817132614322
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	15/413	120/9376	2.83777239709443	PIK3CB/CALM1/SOS2/PIK3R1/BRAF/MAP3K5/NFKBIA/MAPK10/PDPK1/RAC1/RPS6KA5/MAGED1/IRAK2/SH2B2/KRAS	4.34915253947717
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	11/413	71/9376	3.51723902738465	CGA/FOS/PIK3CB/SOS2/PIK3R1/LHB/MAPK10/ESR2/STAT5A/STAT3/KRAS	4.57013898555822
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	27/413	300/9376	2.04319612590799	FLT1/FOS/GADD45G/DUSP1/HSPB1/HSPA1B/SOS2/HSPA8/FGFR1/BRAF/MAP3K13/GADD45B/MAP3K8/RASGRP1/MAP3K5/MAPK10/HSPA1A/RAC1/MAP4K2/DDIT3/NFATC3/MAP3K4/RPS6KA5/ANGPT2/PTPRR/VEGFB/KRAS	3.94197000303303
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	16/413	139/9376	2.61320048077761	FOS/KRT19/PIK3CB/CALM1/HSPA1B/SOS2/KRT10/KRT23/HSPA8/PIK3R1/KRT15/HSPA1A/ESR2/ATF6B/ADCY5/KRAS	4.11305234766128
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	7/413	32/9376	4.96610169491525	GALE/UGP2/PFKL/AKR1B1/PGM1/HK2/B4GALT1	4.82398985568908
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	22/413	227/9376	2.20021119774722	FOS/PIK3CB/PRKD3/SLC26A6/SOS2/MGST3/PIK3R1/BRAF/MAP3K5/NFKBIA/HMOX1/MAPK10/NDUFS2/UQCRC1/SLC25A5/PDPK1/RAC1/SLC25A6/CBR1/NDUFA6/KRAS/MGST2	3.92932322256469
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	16/413	142/9376	2.55799201991611	FOS/DUSP1/PIK3CB/CALM1/ACTG1/SDC1/MGST3/BMPR2/PIK3R1/MAP3K5/TRPV4/HMOX1/MAPK10/RAC1/GSTP1/MGST2	4.01558138004104
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	20/413	204/9376	2.22570384085838	HSPG2/PIK3CB/EZR/TIMP3/ACTG1/SOS2/CD63/SDC1/FGFR1/PIK3R1/BRAF/HPSE/DDX5/CTTN/HPSE2/PDPK1/RAC1/PDCD4/STAT3/KRAS	3.79929112819352
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	20/413	205/9376	2.21484674895175	GADD45G/PIK3CB/HDAC2/CALR/HES1/BLNK/PIK3R1/GADD45B/NFKBIA/MAPK10/PSMC5/TYK2/RAC1/HLA-C/CCND3/IRF3/STAT2/ENTPD1/STAT3/TAPBP	3.77506162396922
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	14/413	119/9376	2.67084460903005	FOS/JUNB/PIK3CB/MMP14/PIK3R1/MAP3K8/CXCL1/MAP3K5/NFKBIA/TNFRSF1B/MAPK10/ATF6B/RPS6KA5/BCL3	3.93738947820998
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	17/413	163/9376	2.36771193868002	FOS/HSPG2/PIK3CB/SOS2/PIK3R1/BRAF/NFKBIA/MAPK10/TYK2/ATF6B/IRF3/DDB1/STAT2/NFATC3/STAT5A/STAT3/KRAS	3.78113227321838
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	14/413	122/9376	2.60516810225063	FOS/PIK3CB/SOS2/PIK3R1/PPP2R2B/MAP3K8/RASGRP1/NFKBIA/MAPK10/PDPK1/NFATC3/PAK4/PAK6/KRAS	3.83062513904661
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	15/413	137/9376	2.48564005584914	FOS/GADD45G/PIK3CB/CSF2RB/ACTG1/PIK3R1/GADD45B/MAP3K5/NFKBIA/MAPK10/PDPK1/DDIT3/TUBA4A/KRAS/LMNA	3.7600651174946
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	13/413	110/9376	2.68298481179837	FLT1/PIK3CB/SERPINE1/EPAS1/PIK3R1/PFKL/EGLN3/GAPDH/SLC2A1/HMOX1/HK2/ANGPT2/STAT3	3.8112229687885
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	14/413	125/9376	2.54264406779661	PIK3CB/ACER2/DEGS1/PIK3R1/PPP2R2B/CERS4/MAP3K5/MAPK10/SPTLC2/PDPK1/RAC1/GAB2/KRAS/ADORA1	3.72700834595948
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	10/413	73/9376	3.10988755845965	GADD45G/PIK3CB/SOS2/PIK3R1/BRAF/GADD45B/PDPK1/STAT5A/STAT3/KRAS	3.88457218921343
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	15/413	142/9376	2.39811751867135	FOS/JUNB/FOSB/PIK3CB/BLNK/PIK3R1/NFKBIA/MITF/MAPK10/TYK2/RAC1/STAT2/SIRPA/GAB2/NCF4	3.60351953239669
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	11/413	87/9376	2.87039047062425	FOS/GADD45G/PIK3CB/SOS2/PIK3R1/BRAF/GADD45B/MAPK10/RAC1/RALB/KRAS	3.762195779068
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	17/413	174/9376	2.21802900002783	MAN1C1/DERL3/HSPA1B/PPP1R15A/CALR/DNAJB1/HSPA8/MAP3K5/UGGT2/CRYAB/MAPK10/UBXN1/HSPA1A/ATF6B/HERPUD1/DDIT3/OS9	3.48116897251041
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	10/413	77/9376	2.94833495802019	GADD45G/PIK3CB/PIK3R1/BRAF/GADD45B/MAPK10/RAC1/RALB/STAT3/KRAS	3.68489254110264
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	20/413	224/9376	2.02698028363888	FOS/PIK3CB/CALR/PIK3R1/NFKBIA/SLC2A1/MAPK10/SLC25A5/ATF6B/HLA-C/ANAPC5/CCND3/SLC25A6/NFATC3/CDC26/EGR1/STAT5A/ADCY5/KAT5/KRAS	3.33935103792108
Human Diseases	Infectious disease: viral	hsa05162	Measles	14/413	136/9376	2.3369890329013	FOS/PIK3CB/HSPA1B/HSPA8/PIK3R1/NFKBIA/MAPK10/HSPA1A/TYK2/CCND3/IRF3/STAT2/STAT5A/STAT3	3.37128353270689
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	12/413	109/9376	2.49932247817491	PIK3CB/PIK3R1/SREBF1/NFKBIA/SLC2A1/MAPK10/MLX/PDPK1/PRKAB2/SLC27A4/FOXO1/STAT3	3.37965746078079
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	14/413	138/9376	2.30311962662736	PIK3CB/CALM1/SOS2/PIK3R1/BRAF/SREBF1/MAPK10/PDPK1/PRKAB2/HK2/SH2B2/FOXO1/TRIP10/KRAS	3.31031114290753
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	9/413	71/9376	2.87774102240562	PIK3CB/FGFR1/PIK3R1/PFKL/SLC2A1/HK2/SLC16A3/KRAS/IDH2	3.40910710422041
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	15/413	157/9376	2.16899801051804	GADD45G/PIK3CB/SERPINE1/CALM1/RAD9A/PIK3R1/GADD45B/TRPV4/SLC25A5/HLA-C/CCND3/SLC25A6/NFATC3/FOXO1/KRAS	3.17070367933532
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	8/413	59/9376	3.07826158328887	GADD45G/PIK3CB/SOS2/PIK3R1/BRAF/GADD45B/PDPK1/KRAS	3.4373371641463
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	11/413	101/9376	2.47251456380505	PIK3CB/SERPINE1/PIK3R1/MAPK10/RAC1/EGR1/STAT5A/VEGFB/FOXO1/STAT3/KRAS	3.19372334174751
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	17/413	196/9376	1.9690665612492	FOS/PIK3CB/CALM1/UBC/PIK3R1/CXCL1/NFKBIA/MAPK10/TYK2/RAC1/HLA-C/IRF3/STAT2/NFATC3/ANGPT2/STAT3/KRAS	2.94302715220492
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	18/413	214/9376	1.90952908963364	FOS/PIK3CB/CALM1/CALR/PIK3R1/NFKBIA/TNFRSF1B/AP1G2/MAPK10/RAC1/HLA-C/IRF3/DDB1/NFATC3/PAK4/PAK6/KRAS/TAPBP	2.88909819211456
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	10/413	91/9376	2.49474496447862	FOS/PIK3CB/SOS2/PIK3AP1/BLNK/PIK3R1/NFKBIA/RAC1/NFATC3/KRAS	3.07560676134006
NA	NA	hsa04517	IgSF CAM signaling	23/413	299/9376	1.74632147513503	NECTIN4/NLGN1/PIK3CB/EZR/LRFN5/ACTG1/FGFR1/PIK3R1/MYL6/JAM3/MAPK10/NLGN4X/PDPK1/RAC1/ACTR3B/PAK4/TUBA4A/CLMP/DYNLL1/GLDN/ARPC1B/FOXO1/PAK6	2.81529773373346
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	11/413	106/9376	2.35588651834255	PIK3CB/SOS2/FGFR1/PIK3R1/BRAF/ETV5/NFKBIA/PDPK1/GSTP1/FOXO1/KRAS	3.01349429706043
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	9/413	78/9376	2.61948221270255	PIK3CB/ACTG1/DNM2/PIK3R1/ELMO3/CTTN/RAC1/ACTR3B/ARPC1B	3.08292300581876
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	7/413	52/9376	3.05606258148631	CGA/CYP11A1/HSD3B1/SCARB1/LDLR/LHB/ADCY5	3.19132353189442
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	10/413	93/9376	2.44109453513499	CGA/CALM1/SOS2/MMP14/LHB/MAPK10/MAP3K4/EGR1/ADCY5/KRAS	2.99794551821287
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	15/413	170/9376	2.00313345677254	GADD45G/PIK3CB/ACTG1/SOS2/MGST3/PIK3R1/BRAF/SMARCA2/GADD45B/SMARCB1/HMOX1/GSTP1/SMARCC2/KRAS/MGST2	2.83322885738969
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	4/413	19/9376	4.77940614247483	HEXB/HPSE/HPSE2/ARSB	3.53969641604975
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	14/413	157/9376	2.02439814315017	FOS/LEP/PIK3CB/PIK3R1/SREBF1/MAP3K5/MAPK10/NDUFS2/MLX/UQCRC1/RAC1/PRKAB2/DDIT3/NDUFA6	2.77850170177034
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	6/413	42/9376	3.24316845382221	KMO/KYNU/GCDH/KYAT1/MAOA/AOC1	3.12742282514596
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	8/413	68/9376	2.67084460903005	PIK3CB/SOS2/PIK3R1/BRAF/STAT5A/RUNX1/STAT3/KRAS	2.96822143228306
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	8/413	69/9376	2.63213671614556	PIK3CB/SOS2/PIK3R1/MAPK10/PDPK1/RAC1/GAB2/KRAS	2.9208562850852
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	10/413	98/9376	2.31654889558729	PIK3CB/CALM1/IMPA2/DGKG/PIK3R1/INPP5B/IPMK/IP6K2/DGKZ/MTMR4	2.81226869608221
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	13/413	144/9376	2.04950228679042	INHBA/PIK3CB/DLX5/KLF4/LIFR/BMPR2/FGFR1/PIK3R1/ID3/ID1/MEIS1/STAT3/KRAS	2.7242734830538
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	8/413	70/9376	2.59453476305777	LEP/NFKBIA/SLC2A1/TNFRSF1B/MAPK10/PRKAB2/ACSBG2/STAT3	2.87432222930712
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	10/413	99/9376	2.29314941179348	FOS/PIK3CB/SOS2/DGKG/PIK3R1/MAPK10/DGKZ/PDPK1/RAC1/KRAS	2.77649241528079
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	11/413	115/9376	2.17151279082009	FOS/GCM1/SGK1/MMP14/WNK2/FGFR1/BRAF/MMP24/ATF6B/EGR1/ADCY5	2.71331976589854
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	17/413	212/9376	1.82045776417379	FLT1/PIK3CB/PRKD3/CALM1/ACTG1/RAPGEF3/FGFR1/PIK3R1/BRAF/ID1/RAC1/SIPA1L3/ANGPT2/ADCY5/VEGFB/RALB/KRAS	2.59367517470965
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	8/413	71/9376	2.55799201991611	CXCL1/ATP6V1C2/NFKBIA/JAM3/MAPK10/RAC1/ATP6V1F/TCIRG1	2.82859116355151
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	9/413	86/9376	2.37580944873022	PIK3CB/SOS2/PIK3R1/BRAF/MAPK10/PAK4/STAT5A/PAK6/KRAS	2.75127259467726
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	19/413	248/9376	1.73927985628368	FOS/SNX9/PIK3CB/ACTG1/RHOB/DNM2/GSDMD/DYNC2H1/NFKBIA/GAPDH/STX10/MAPK10/RAC1/CYFIP2/ACTR3B/TUBA4A/DYNLL1/ARPC1B/VPS16	2.53268316358055
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	18/413	232/9376	1.76137597061034	PIK3CB/EZR/ACTG1/SOS2/ARHGEF4/GSN/FGFR1/PIK3R1/BRAF/RAC1/CHRM2/CYFIP2/RGCC/ACTR3B/PAK4/ARPC1B/PAK6/KRAS	2.52062950601856
Human Diseases	Cancer: specific types	hsa05218	Melanoma	8/413	73/9376	2.48791004676772	GADD45G/PIK3CB/FGFR1/PIK3R1/BRAF/GADD45B/MITF/KRAS	2.73943223398351
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	14/413	168/9376	1.89184826472962	LEP/PIK3CB/CSF2RB/SOS2/LIFR/FHL1/PIK3R1/OSMR/IL11RA/TYK2/CCND3/STAT2/STAT5A/STAT3	2.50378436432158
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	10/413	105/9376	2.16211230254814	PIK3CB/CALM1/PIK3R1/NFKBIA/MAPK10/PLK3/STAT2/NFATC3/BCL3/KRAS	2.57047523246092
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	16/413	203/9376	1.78933431935018	FLT1/FLNB/PIK3CB/ACTG1/SOS2/LAMA5/PIK3R1/BRAF/MAPK10/PDPK1/RAC1/CCND3/PAK4/EMP2/VEGFB/PAK6	2.44054755158444
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	5/413	35/9376	3.24316845382221	PFKL/AKR1B1/PFKFB4/HK2/ENOSF1	2.85386345851374
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	14/413	170/9376	1.86959122632104	EZR/ACTG1/PPP2R2B/MYL6/MAP3K5/JAM3/MAPK10/CTTN/RAC1/PRKAB2/ACTR3B/TUBA4A/ARPC1B/RUNX1	2.45605501432728
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	8/413	76/9376	2.38970307123742	PLIN2/UBC/LPL/ANGPTL4/HMGCS2/PDPK1/SLC27A4/ACSBG2	2.61108677433207
Human Diseases	Cancer: specific types	hsa05214	Glioma	8/413	76/9376	2.38970307123742	GADD45G/PIK3CB/CALM1/SOS2/PIK3R1/BRAF/GADD45B/KRAS	2.61108677433207
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	11/413	122/9376	2.04691779462549	PIK3CB/ACTG1/HDAC2/PIK3R1/PFKL/SLC2A1/MED12L/DIO2/PDPK1/FOXO1/KRAS	2.49839852722259
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	11/413	122/9376	2.04691779462549	FOS/JUNB/PIK3CB/SOS2/PIK3R1/MAPK10/ATF6B/STAT5A/ADCY5/STAT3/KRAS	2.49839852722259
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	12/413	138/9376	1.97410253710917	FOS/PIK3CB/ACTG1/PIK3R1/ARHGEF28/NFKBIA/MAPK10/RAC1/IRF3/ACTR3B/NFATC3/ARPC1B	2.47450995061182
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	13/413	156/9376	1.89184826472962	PIK3CB/SOS2/SCARB1/LDLR/PIK3R1/BRAF/PPP2R2B/NFKBIA/TYK2/IRF3/STAT2/STAT3/KRAS	2.41113638133503
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	8/413	78/9376	2.32842863351338	PIK3CB/PIP5KL1/IMPA2/INPP5B/ISYNA1/IPMK/IP6K2/MTMR4	2.52885963410021
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	10/413	109/9376	2.08276873181243	FOS/PIK3CB/PIK3R1/MAP3K8/NFKBIA/MAPK10/TYK2/RAC1/IRF3/STAT2	2.44069403082951
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	5/413	37/9376	3.0678620509129	GALE/UGP2/PGM1/HK2/NANS	2.70524251030437
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	10/413	110/9376	2.06383447061413	SPDYE2/PIK3CB/PIK3R1/BRAF/MAPK10/ANAPC5/SPDYE3/CDC26/ADCY5/KRAS	2.40911881139382
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	5/413	38/9376	2.98712883904677	GALE/HEXB/UGP2/PGM1/HK2	2.63466168451368
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	5/413	38/9376	2.98712883904677	PIK3CB/SGK1/PIK3R1/PDPK1/KRAS	2.63466168451368
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	10/413	112/9376	2.02698028363888	HSPA1B/LAMA5/LDLR/HSPA8/NFKBIA/MAPK10/HSPA1A/PDPK1/TYK2/STAT3	2.34696065954214
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	9/413	98/9376	2.08489400602856	PIK3CB/GSN/DNM2/PIK3R1/RAC1/MYO10/ACTR3B/GAB2/ARPC1B	2.31743269235765
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	9/413	99/9376	2.06383447061413	FOS/PIK3CB/SOS2/PIK3R1/BRAF/MAPK10/ESR2/ADCY5/KRAS	2.28413539211825
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	16/413	217/9376	1.67389339552114	FOS/PIK3CB/SOS2/PAQR7/KLF4/MGST3/PIK3R1/BCL6/ESR2/ATF6B/CCND3/STAT5A/ADCY5/STAT3/KRAS/MGST2	2.15591186836121
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	7/413	69/9376	2.30311962662736	FOS/FOSB/CALM1/HDAC2/MAOA/ATF6B/ADCY5	2.33205044283371
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	4/413	28/9376	3.24316845382221	AKR1B1/GPHN/MOCOS/CBR1	2.55161718464475
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	17/413	238/9376	1.6215842269111	FLT1/PIK3CB/CALM1/SOS2/FGFR1/PIK3R1/RASGRP1/MAPK10/RAC1/PAK4/ANGPT2/GAB2/VEGFB/RGL2/RALB/PAK6/KRAS	2.0849558016204
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	19/413	275/9376	1.56851419766674	PIK3CB/HSPA1B/HSPA8/PIK3R1/MAPK10/NDUFS2/PSMC5/UQCRC1/SLC25A5/HSPA1A/ATF6B/RAC1/SLC25A6/DDIT3/TUBA4A/NDUFA6/EGR1/NCF4/PSMA1	2.05398406731539
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	10/413	122/9376	1.86083435875045	LEP/PIK3CB/PIK3R1/PPP2R2B/SREBF1/PFKL/PFKFB4/PDPK1/PRKAB2/FOXO1	2.05432298994792
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	8/413	90/9376	2.01797148237826	FOS/PIK3CB/PIK3R1/RASGRP1/NFKBIA/NFATC3/STAT3/KRAS	2.08293871731797
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	6/413	59/9376	2.30869618746666	PRDX6/MGST3/GGT7/GSTP1/MGST2/IDH2	2.16451580394268
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	7/413	75/9376	2.11887005649718	PIK3CB/MGST3/PIK3R1/MAP3K5/PDPK1/GSTP1/MGST2	2.0882352698154
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	5/413	45/9376	2.52246435297283	ABCA1/ABCB1/ABCG1/ABCD1/ABCD4	2.1974715486185
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	17/413	250/9376	1.54374818401937	PIP5KL1/HSPA1B/RNF103-CHMP3/DAB2/LDLR/DNM2/HSPA8/RAB11A/HSPA1A/IGF2R/IQSEC1/HLA-C/ACTR3B/SNX3/RAB11FIP5/ARPC1B/EPS15L1	1.87051656013956
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	9/413	109/9376	1.87449185863118	FOS/EBI3/NFKBIA/MAPK10/TYK2/NFATC3/STAT5A/RUNX1/STAT3	1.97121231585388
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	8/413	93/9376	1.952875628108	FOS/MAML2/NFKBIA/MAPK10/TYK2/NFATC3/STAT5A/MAML3	1.98229134109723
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	13/413	180/9376	1.63960182943234	PIK3CB/PILRB/CALR/SRSF7/PIK3R1/NFKBIA/SRSF5/TYK2/HLA-C/IRF3/STAT2/SRSF3/TAPBP	1.85986077165406
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	4/413	33/9376	2.75177929415218	GPT2/OGDH/IDH3B/IDH2	2.16384999129892
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	3/413	20/9376	3.40532687651332	UGP2/CYB5R1/NANS	2.31141517970502
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	10/413	130/9376	1.74632147513503	FOS/PIK3CB/SOS2/PIK3R1/NFKBIA/MAPK10/ATF6B/ADCY5/VEGFB/KRAS	1.83930874577054
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	11/413	148/9376	1.68732412800209	FOS/GADD45G/PIK3CB/SOS2/HES1/FGFR1/PIK3R1/BRAF/GADD45B/ESR2/KRAS	1.80914185117015
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	11/413	149/9376	1.67599980499537	PIK3CB/SOS2/RAPGEF3/DNM2/DGKG/PIK3R1/DGKZ/GAB2/ADCY5/RALB/KRAS	1.78543239500903
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	6/413	65/9376	2.09558577016204	CYP11A1/HSD3B1/SCARB1/LDLR/ATF6B/ADCY5	1.90256219873469
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	6/413	65/9376	2.09558577016204	CGA/PIK3CB/PIK3R1/LHB/ESR2/KRAS	1.90256219873469
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	8/413	98/9376	1.85323911646983	PRKD3/CALM1/CYP11A1/HSD3B1/SCARB1/LDLR/ATF6B/ADCY5	1.82259668863309
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	14/413	205/9376	1.55039272426623	PIK3CB/HDAC2/GSN/PIK3R1/NFKBIA/ATF6B/RAC1/HLA-C/CCND3/IRF3/DDB1/STAT5A/STAT3/KRAS	1.71031157080688
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	7/413	82/9376	1.93799090533278	HSPA1B/CALR/HSPA8/HSPA1A/HLA-C/HSPA2/TAPBP	1.8312101440418
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	12/413	169/9376	1.6119890539708	PIK3CB/UBC/PIK3R1/ATG4B/OPTN/MAPK10/ATG16L2/MTMR4/PDPK1/VAMP8/VPS16/KRAS	1.72330401948988
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	15/413	226/9376	1.50678180376695	CGA/FOS/PIK3CB/CRH/CALM1/RAPGEF3/PIK3R1/BRAF/NFKBIA/LHB/MAPK10/RAC1/CHRM2/ADCY5/ADORA1	1.65538361146259
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	15/413	227/9376	1.50014399846402	PIK3CB/CALM1/SOS2/CALR/PIK3R1/NFKBIA/ATF6B/RAC1/HLA-C/IRF3/NFATC3/ADCY5/STAT3/KRAS/TAPBP	1.63740134359662
NA	NA	hsa04518	Integrin signaling	11/413	154/9376	1.6215842269111	FLT1/FLNB/PIK3CB/ACTG1/NPNT/LAMA5/PIK3R1/LIMS2/RAC1/CCND3/VEGFB	1.669482045309
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	5/413	52/9376	2.18290184391879	SCARB1/ABCA1/LDLR/LPL/ANGPTL4	1.83604454670364
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	4/413	37/9376	2.45428964073032	GADD45G/BRAF/GADD45B/KRAS	1.90254768525884
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	12/413	173/9376	1.5747176307576	PIK3CB/ACTG1/DNAJB1/PIK3R1/NFKBIA/RAB11A/SLC25A5/TYK2/CCND3/IRF3/STAT2/SLC25A6	1.63774705315796
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	11/413	155/9376	1.6111223931891	ACTG1/SCARB1/CALR/DYNC2H1/ATP6V1C2/RAC1/HLA-C/ATP6V1F/TUBA4A/TCIRG1/NCF4	1.64679295963468
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	8/413	103/9376	1.76327605256353	FOS/PIK3CB/SERPINE1/CALR/PIK3R1/PPP2R2B/NFKBIA/MAPK10	1.6719530777272
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	13/413	193/9376	1.52916232796798	PIK3CB/SOS2/DOCK2/PIK3R1/BRAF/CXCL1/NFKBIA/RAC1/STAT2/ADCY5/CCL28/STAT3/KRAS	1.59444391184393
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	11/413	157/9376	1.59059854104656	SGK1/ABCA1/CALR/P2RY6/SLC2A1/ADAM9/RAC1/RAB17/SIRPA/NFATC3/VPS16	1.6018957690754
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	11/413	158/9376	1.58053146167285	PIK3CB/SOS2/SGK1/CASTOR2/FNIP2/PIK3R1/BRAF/ATP6V1C2/PDPK1/ATP6V1F/KRAS	1.57968290573254
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	4/413	39/9376	2.32842863351338	MTHFD1L/MTHFS/ALDH1L2/AHCY	1.78443534922188
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	8/413	105/9376	1.72968984203851	UBC/MTX1/MITF/OPTN/MAPK10/FKBP8/SIAH1/KRAS	1.61400035282788
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	5/413	55/9376	2.06383447061413	ACER2/HEXB/DEGS1/CERS4/SPTLC2	1.69847091729884
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	20/413	333/9376	1.36349424485018	PIK3CB/SOS2/MAML2/LAMA5/HDAC2/HES1/PIK3R1/PPP2R2B/ATP6V1C2/TYK2/HLA-C/CCND3/IRF3/STAT2/ATP6V1F/TCIRG1/MAML3/FOXO1/TUBG2/KRAS	1.44976415011265
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	5/413	56/9376	2.02698028363888	HSPA1B/HSPA8/CXCL1/NFKBIA/HSPA1A	1.65455850765669
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	7/413	90/9376	1.76572504708098	PIK3CB/PIK3R1/ATF6B/PRKAB2/ADCY5/FOXO1/KRAS	1.56680061769396
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	10/413	144/9376	1.57654022060802	PIK3CB/PIK3R1/MAP3K5/NOP56/MAPK10/PSMC5/SLC25A5/SLC25A6/KAT5/PSMA1	1.49656961655583
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	13/413	200/9376	1.4756416464891	FOS/EZR/ACTG1/NFKBIA/GAPDH/MAPK10/CTTN/RAC1/CYFIP2/MYO10/ACTR3B/TUBA4A/ARPC1B	1.4594933986797
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	13/413	201/9376	1.4683001457603	FLT1/GADD45G/HDAC2/GADD45B/ETV5/MITF/BCL6/DDX5/MEIS1/DDIT3/NFKBIZ/RUNX1/FOXO1	1.44063264260482
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	6/413	75/9376	1.81617433414044	GADD45G/SERPINE1/GADD45B/CCND3/SIAH1/TP53I3	1.52329041337112
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	12/413	184/9376	1.48057690283188	PIK3CB/BMPR2/PIK3R1/SEMA4C/SEMA4B/PDPK1/RAC1/NFATC3/PAK4/PLXNB1/PAK6/KRAS	1.41319067700532
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	3/413	27/9376	2.52246435297283	HMGCS2/L2HGDH/AACS	1.70051474043629
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	5/413	59/9376	1.92391348955555	UCK2/ENTPD1/NT5E/CTPS2/CTPS1	1.52810512384087
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	5/413	59/9376	1.92391348955555	CGA/PIK3CB/PIK3R1/ADCY5/ADORA1	1.52810512384087
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	5/413	60/9376	1.89184826472962	PIK3CB/HSPB1/PIK3R1/RAC1/KRAS	1.48759881153305
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	3/413	28/9376	2.43237634036665	ATP6V1C2/ATP6V1F/TCIRG1	1.62933643201448
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/413	14/9376	3.24316845382221	ST3GAL1/B4GALT1	1.80291625369804
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	4/413	44/9376	2.06383447061413	AQP3/DYNC2H1/RAB11A/DYNLL1	1.51826296120336
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	16/413	268/9376	1.35535398070182	DUSP1/CALM1/UBC/MAP3K5/MAOA/MAPK10/NDUFS2/PSMC5/UQCRC1/SLC25A5/SLC25A6/DDIT3/TUBA4A/NDUFA6/ADCY5/PSMA1	1.26692538093235
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	5/413	62/9376	1.83082090135125	MAML2/HDAC2/HES1/TLE6/MAML3	1.40886411535262
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	15/413	250/9376	1.36213075060533	CD63/HEXB/ATP6V1C2/AP1G2/MITF/AP3S1/IGF2R/ATP6V1F/SLC11A1/TCIRG1/VAMP8/VPS16/SLC15A3/SPG11/ARSB	1.24574497138716
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	8/413	116/9376	1.56566752943141	PIK3CB/EZR/ACTG1/RAPGEF3/PIK3R1/JAM3/RAC1/NCF4	1.31588736555293
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/413	15/9376	3.02695722356739	ST3GAL1/HEXB	1.68640956300653
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	6/413	80/9376	1.70266343825666	PIK3CB/SOS2/PIK3R1/BRAF/STAT3/KRAS	1.35480957784639
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	3/413	30/9376	2.27021791767555	OGDH/IDH3B/IDH2	1.49575319583149
Cellular Processes	Cell motility	hsa04814	Motor proteins	12/413	194/9376	1.40425850577869	ACTG1/MYO7B/KIF2A/MYL6/DYNC2H1/MYO10/TUBA4A/KIF26B/DYNLL1/TPM4/DNAH11/TUBG2	1.22130842491592
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	4/413	47/9376	1.93210035546855	PIK3CB/PIK3R1/MAPK10/HK2	1.37508017848467
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/413	16/9376	2.83777239709443	ST3GAL1/HEXB	1.57923862350795
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	5/413	65/9376	1.74632147513503	DGKG/LPL/AKR1B1/DGKZ/PLPP5	1.29604004119715
NA	NA	hsa03272	Virion - Hepatitis viruses	4/413	48/9376	1.89184826472962	HSPG2/SCARB1/CD63/LDLR	1.32969270903839
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	4/413	48/9376	1.89184826472962	PIK3CB/PIK3R1/SLC2A5/HK2	1.32969270903839
NA	NA	hsa04382	Cornified envelope formation	13/413	217/9376	1.36003838386093	KRT19/S100A6/LAMA5/KRT7/KRT10/KRT23/PPP2R2B/TCHH/KRT15/KRT8/SPTLC2/PPL/SLC27A4	1.15183058624739
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	4/413	49/9376	1.85323911646983	FUT10/GALNT17/GALNT2/B4GALT1	1.2853807002479
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	4/413	49/9376	1.85323911646983	FOSB/MAOA/ATF6B/ADCY5	1.2853807002479
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	2/413	17/9376	2.67084460903005	CDO1/GGT7	1.48006150990511
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	6/413	85/9376	1.60250676541803	UCK2/GUK1/ENTPD1/NT5E/CTPS2/CTPS1	1.19777191734122
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	3/413	33/9376	2.06383447061413	VAMP8/STX8/USE1	1.31408004288348
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	4/413	50/9376	1.81617433414044	SAT1/MAOA/P4HA1/AOC1	1.24209323383542
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	9/413	144/9376	1.41888619854722	SREBF1/CXCL1/MAP3K5/NFKBIA/ACADVL/MAPK10/PRKAB2/IRF3/FOXO1	1.08733499438984
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	4/413	51/9376	1.7805630726867	ACTG1/ATP6V1C2/ATP6V1F/TCIRG1	1.19978280988781
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	2/413	18/9376	2.52246435297283	HEXB/MAN2C1	1.38779663711224
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	3/413	34/9376	2.00313345677254	BHLHE40/CSNK1E/PRKAB2	1.25780178934641
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	21/413	388/9376	1.22872619255635	PIK3CB/CALM1/MME/LPL/PIK3R1/BRAF/MAP3K5/GAPDH/MAPK10/CSNK1E/NDUFS2/PSMC5/UQCRC1/SLC25A5/SLC25A6/DDIT3/APBB1/TUBA4A/NDUFA6/KRAS/PSMA1	0.987720795204358
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	12/413	205/9376	1.32890804937105	PIK3CB/PIK3R1/GAPDH/SLC2A1/MAPK10/NDUFS2/UQCRC1/SLC25A5/RAC1/SLC25A6/NDUFA6/NCF4	1.0220615530861
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/413	36/9376	1.89184826472962	UGP2/DCXR/AKR1B1	1.15080767524616
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	3/413	36/9376	1.89184826472962	UGP2/PGM1/HK2	1.15080767524616
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	3/413	36/9376	1.89184826472962	ST3GAL1/GALNT17/GALNT2	1.15080767524616
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	7/413	110/9376	1.44468412942989	INHBA/GREM2/HDAC2/BMPR2/ID3/ID1/LRRC32	1.00701465399913
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	14/413	253/9376	1.25624706906947	PIK3CB/ACTG1/UBC/PIK3R1/NFKBIA/MAPK10/CTTN/RAC1/IRF3/ACTR3B/HK2/RPS6KA5/ARPC1B/FOXO1	0.886919688191712
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	6/413	93/9376	1.464656721081	GADD45G/PIK3CB/LAMA5/PIK3R1/GADD45B/NFKBIA	0.966637163981591
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	6/413	94/9376	1.44907526660141	FOS/FOSB/CXCL1/NFKBIA/MAPK10/ANAPC5	0.939282534609404
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	3/413	38/9376	1.79227730342806	QPRT/NT5E/SIRT7	1.05045159319063
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	5/413	75/9376	1.5134786117837	GPT2/PFKL/GAPDH/IDH3B/IDH2	0.958345556926851
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	13/413	235/9376	1.25586523105456	ACTG1/SOS2/FGFR1/SMARCA2/MAP3K5/SMARCB1/NDUFS2/UQCRC1/PRKAB2/NDUFA6/ADCY5/SMARCC2/KRAS	0.852672618866299
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	9/413	154/9376	1.32675073110908	RDH13/KMO/KYNU/QPRT/UGP2/MTHFD1L/GPHN/CTPS2/CTPS1	0.877603477149075
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	6/413	95/9376	1.43382184274245	FLT1/FOS/CXCL1/ATP6V1C2/ATP6V1F/TCIRG1	0.912241440066073
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	4/413	57/9376	1.59313538082494	TECR/ACADVL/ACSBG2/HACD2	0.964141037504497
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	7/413	116/9376	1.36995908825248	GPT2/PFKL/GAPDH/OGDH/HK2/IDH3B/IDH2	0.86061947110923
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/413	22/9376	2.06383447061413	MAOA/AOC1	1.07231080411935
NA	NA	hsa04081	Hormone signaling	12/413	219/9376	1.24395502338386	CGA/LEP/PIK3CB/CRH/RAPGEF3/PIK3R1/LHB/DIO2/ESR2/STAT5A/ADCY5/STAT3	0.784132007024742
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	10/413	178/9376	1.27540332453682	LGR4/MAPK10/CSNK1E/RAC1/CCND3/NFATC3/TLE6/ROR2/SIAH1/CCDC88C	0.796281164496038
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/413	23/9376	1.97410253710917	PREP/MME	1.00398469218668
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	3/413	41/9376	1.66113506171381	BRAF/RPS6KA5/KRAS	0.910665581072931
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	6/413	99/9376	1.37588964707609	PIK3CB/CALM1/PIK3R1/TRPV4/MAPK10/ADCY5	0.807064322630652
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	3/413	42/9376	1.6215842269111	SAT1/HMOX1/LPCAT3	0.866611999504594
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/413	24/9376	1.89184826472962	EXT1/XYLT1	0.939027496121454
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	3/413	43/9376	1.58387296582015	GCDH/ACADVL/ACSBG2	0.823713014747051
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	3/413	43/9376	1.58387296582015	SCARB1/ABCA1/SLC27A4	0.823713014747051
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	6/413	103/9376	1.32245703942265	PIK3CB/HSPB1/LAMA5/PIK3R1/CXCL1/SERPINB9	0.70634082870381
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	5/413	83/9376	1.36760115522623	ABCD1/NUDT19/ABCD4/ECH1/IDH2	0.722057712157879
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	3/413	44/9376	1.5478758529606	MAN1C1/HEXB/B4GALT1	0.781906995744914
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/413	26/9376	1.74632147513503	SCARB1/ABCD4	0.817976398327583
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	18/413	362/9376	1.1288376386232	FLT1/PIK3CB/SOS2/SGK1/PIK3AP1/LAMA5/FGFR1/PIK3R1/PPP2R2B/OSMR/PDPK1/ATF6B/RAC1/CHRM2/CCND3/ANGPT2/VEGFB/KRAS	0.536626642225347
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	6/413	107/9376	1.27301939308909	CALM1/PFKL/SLC2A1/PRKAB2/PRMT1/FOXO1	0.609681350305302
Human Diseases	Substance dependence	hsa05034	Alcoholism	10/413	191/9376	1.18859576841652	FOSB/CRH/CALM1/SOS2/HDAC2/BRAF/MAOA/ATF6B/ADCY5/KRAS	0.565253178632103
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	7/413	128/9376	1.24152542372881	PGM1/GUK1/ENTPD1/PDE6D/ADCY5/PDE7A/NT5E	0.590578854067303
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	2/413	27/9376	1.68164290198189	TECR/HACD2	0.761360225131426
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	8/413	150/9376	1.21078288942696	GADD45G/PIK3CB/SOS2/ABCB1/PIK3R1/BRAF/GADD45B/KRAS	0.558609379738443
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	4/413	67/9376	1.35535398070182	PFKL/GAPDH/PGM1/HK2	0.626586504591546
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	4/413	67/9376	1.35535398070182	CALM1/RAPGEF3/BRAF/KRAS	0.626586504591546
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	2/413	28/9376	1.6215842269111	TECR/HACD2	0.707055679384211
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/413	28/9376	1.6215842269111	B3GNT5/B4GALT1	0.707055679384211
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	12/413	238/9376	1.14464768958431	FOS/PIK3CB/RPL10A/PIK3R1/NFKBIA/MAPK10/TYK2/IRF3/STAT2/RPS9/STAT3/CFB	0.485186120453025
Organismal Systems	Digestive system	hsa04976	Bile secretion	5/413	90/9376	1.26123217648641	SCARB1/ABCB1/LDLR/SLC2A1/ADCY5	0.534524418445939
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/413	29/9376	1.56566752943141	LIMD1/CSNK1E	0.654874520420305
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	8/413	154/9376	1.17933398320808	FOS/CALM1/ACTG1/MYL6/PRKAB2/NFATC3/ADCY5/KRAS	0.481664193069115
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	7/413	133/9376	1.19485153561871	PIK3CB/SOS2/PIK3R1/BRAF/RAC1/HLA-C/KRAS	0.485799588486419
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	7/413	133/9376	1.19485153561871	FOS/CALM1/PPP2R2B/MAOA/MAPK10/ATF6B/ADCY5	0.485799588486419
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	4/413	70/9376	1.29726738152888	MGST3/CBR1/GSTP1/MGST2	0.535856766858983
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	4/413	70/9376	1.29726738152888	ACTG1/DMD/RAC1/HLA-C	0.535856766858983
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	8/413	155/9376	1.1717253768648	CRH/CYP11A1/HSD3B1/SCARB1/LDLR/BRAF/ATF6B/ADCY5	0.462748779562487
Genetic Information Processing	Transcription	hsa03040	Spliceosome	12/413	243/9376	1.12109526798792	HSPA1B/SRSF7/HSPA8/SRSF5/DDX5/HSPA1A/SNRPA/SRSF3/RBM22/RBM8A/SF3B2/BCAS2	0.410541955327812
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	8/413	157/9376	1.15679893894295	SERPINE1/ACTG1/LIMD1/BMPR2/PPP2R2B/CSNK1E/ID1/CCND3	0.425289836380456
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	8/413	158/9376	1.14947742667116	GADD45G/HDAC2/CCNH/GADD45B/DDX11/ANAPC5/CCND3/CDC26	0.406742702669215
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	6/413	115/9376	1.1844615222655	FOS/PIK3CB/PIK3R1/CHRM2/ADCY5/KRAS	0.427228023742153
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	6/413	115/9376	1.1844615222655	DUSP1/RAPGEF3/BRAF/MAOA/ADCY5/KRAS	0.427228023742153
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	2/413	31/9376	1.464656721081	PFKL/PGM1	0.556233809890895
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4/413	73/9376	1.24395502338386	MGST3/MAOA/GSTP1/MGST2	0.449152323523679
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	4/413	73/9376	1.24395502338386	SMARCB1/RANBP2/SERINC5/ELL	0.449152323523679
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	7/413	138/9376	1.15155981331368	ATP12A/ATP6V1C2/NDUFS2/UQCRC1/ATP6V1F/TCIRG1/NDUFA6	0.385006969872563
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	6/413	117/9376	1.16421431675669	ACTG1/HDAC2/SMARCA2/SMARCB1/SMARCC2/KAT5	0.383668259855814
NA	NA	hsa04519	Cadherin signaling	19/413	404/9376	1.06767674346127	KRT19/ACTG1/LIMD1/KRT7/KRT10/KRT23/FGFR1/NFKBIA/FMN1/KRT15/TMC5/MAPK10/KRT8/RAC1/CYFIP2/ACTR3B/TMC4/ARPC1B/KRAS	0.298482908971034
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/413	12/9376	1.89184826472962	NECTIN4	0.663567119300781
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	3/413	54/9376	1.26123217648641	KYAT1/CDO1/AHCY	0.413240582681993
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	4/413	76/9376	1.19485153561871	EZR/CALM1/ACTG1/ADCY5	0.366102859051237
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	7/413	142/9376	1.1191215087133	RHOBTB1/UBC/MID1/ANAPC5/DDB1/CDC26/SIAH1	0.307024751241838
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	5/413	99/9376	1.14657470589674	KRT19/KRT10/KRT23/KRT15/CFB	0.314707299468117
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	5/413	99/9376	1.14657470589674	ACTG1/DMD/PRKAB2/TPM4/LMNA	0.314707299468117
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	3/413	56/9376	1.21618817018333	MAN1C1/MGAT3/B4GALT1	0.348298776451812
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	11/413	233/9376	1.0717766993318	HSPG2/ACTG1/SDC3/COL27A1/SDC1/FHL1/DMD/FMNL1/TPM4/FMNL3/LMNA	0.238150254396558
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	4/413	78/9376	1.16421431675669	FOS/CALM1/MAPK10/IRF3	0.312606147226016
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	17/413	368/9376	1.04874197283925	ACTG1/SRSF7/MAP3K5/TNFRSF1B/OPTN/NDUFS2/PSMC5/UQCRC1/RANBP2/RAC1/SRSF3/DDIT3/TUBA4A/NDUFA6/SPG11/DNAH11/PSMA1	0.204760786833722
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	5/413	101/9376	1.12387025627502	CALM1/MITF/ADCY5/KRAS/ASIP	0.26866106355615
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4/413	79/9376	1.14947742667116	MGST3/CBR1/GSTP1/MGST2	0.286385950535623
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	4/413	79/9376	1.14947742667116	DNM2/ATP6V1C2/ATP6V1F/TCIRG1	0.286385950535623
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	8/413	168/9376	1.08105615127407	RNF103-CHMP3/MAPK10/SLC25A5/TYK2/STAT2/SLC25A6/STAT5A/STAT3	0.227557906673312
Organismal Systems	Immune system	hsa04611	Platelet activation	6/413	126/9376	1.08105615127407	PIK3CB/ACTG1/PIK3R1/RASGRP1/VAMP8/ADCY5	0.196623014721522
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/413	37/9376	1.22714482036516	FAHD1/MAOA	0.297158035167773
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	4/413	82/9376	1.10742337447588	UCK2/MGST3/GSTP1/MGST2	0.209719275452499
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	9/413	195/9376	1.04779288508102	PIK3CB/ACTG1/HDAC2/PIK3R1/GSDMD/SLC25A5/RAC1/SLC25A6/NCF4	0.144766983749386
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	5/413	105/9376	1.08105615127407	GADD45G/BLNK/GADD45B/CXCL1/NFKBIA	0.179288033378314
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	5/413	105/9376	1.08105615127407	ACTG1/DMD/TPM4/ADCY5/LMNA	0.179288033378314
Organismal Systems	Nervous system	hsa04730	Long-term depression	3/413	60/9376	1.13510895883777	CRH/BRAF/KRAS	0.225361123122744
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/413	16/9376	1.41888619854722	MAOA	0.359958210628295
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	7/413	154/9376	1.03191723530707	CALM1/RAPGEF3/PPP2R2B/ATF6B/RPS6KA5/TPM4/ADCY5	0.0857249089891551
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	3/413	63/9376	1.08105615127407	GCDH/KMT2E/CAMKMT	0.138562406593373
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/413	17/9376	1.33542230451503	KYAT1	0.297122568905168
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	21/413	480/9376	0.993220338983051	CALM1/UBC/BRAF/MAP3K5/TNFRSF1B/OPTN/MAPK10/CSNK1E/NDUFS2/PSMC5/UQCRC1/SLC25A5/RAC1/SLC25A6/DDIT3/TUBA4A/NDUFA6/SPG11/DNAH11/KRAS/PSMA1	-0.0327314448851769
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	13/413	298/9376	0.990363521133627	LEP/EBI3/INHBA/CSF2RB/GDF15/LIFR/BMPR2/INHA/CXCL1/OSMR/TNFRSF1B/IL11RA/CCL28	-0.0362881962799178
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	4/413	89/9376	1.02032265962946	HSPG2/NPNT/LAMA5/SDC1	0.041349645431526
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	4/413	89/9376	1.02032265962946	SOS2/TUBA4A/ADCY5/KRAS	0.041349645431526
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/413	18/9376	1.26123217648641	ACSBG2	0.238125204918887
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/413	18/9376	1.26123217648641	ABCD4	0.238125204918887
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3/413	66/9376	1.03191723530707	CYP11A1/HSD3B1/STS	0.0558542672273829
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	7/413	160/9376	0.993220338983051	NLGN1/SDC3/SDC1/JAM3/NLGN4X/HLA-C/ALCAM	-0.0185665282955222
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	14/413	323/9376	0.98399538227423	PIK3CB/EZR/TIMP3/SOS2/HDAC2/BMPR2/ABCB1/PIK3R1/HMOX1/PAK4/RPS6KA5/PDCD4/STAT3/KRAS	-0.0628324901996
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	6/413	138/9376	0.987051268554585	SPDYE2/CALM1/ANAPC5/SPDYE3/CDC26/ADCY5	-0.0328936262752895
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/413	19/9376	1.19485153561871	OGDH	0.182493030992348
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	2/413	44/9376	1.03191723530707	CCNH/TAF7	0.0455510302864655
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	8/413	187/9376	0.971216221465474	GSDMD/CXCL1/NFKBIA/MAPK10/CARD16/TYK2/IRF3/STAT2	-0.0853431066261679
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	6/413	140/9376	0.972950536146662	SERPINE1/CALM1/PRKAB2/EGR1/ADCY5/KRAS	-0.0692173045286685
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	4/413	93/9376	0.976437814053998	NECTIN4/ACTG1/FGFR1/RAC1	-0.049017013134047
Organismal Systems	Endocrine system	hsa04924	Renin secretion	3/413	69/9376	0.987051268554585	CALM1/ADCY5/ADORA1	-0.0231729261722267
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/413	20/9376	1.13510895883777	FDFT1	0.129833870573324
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	7/413	166/9376	0.957320808658362	CALM1/SLC25A5/ATF6B/SLC25A6/NFATC3/ADCY5/ADORA1	-0.119089748153434
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	13/413	308/9376	0.958208861356561	HDAC2/MAP3K5/TGM2/MAPK10/NDUFS2/PSMC5/UQCRC1/SLC25A5/SLC25A6/TUBA4A/NDUFA6/DNAH11/PSMA1	-0.160080256848471
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	2/413	46/9376	0.987051268554585	PSMC5/PSMA1	-0.0188972793696716
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/413	21/9376	1.08105615127407	XYLT1	0.0798192597700348
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	3/413	72/9376	0.94592413236481	NFKBIA/MAPK10/IRF3	-0.098870984697192
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	4/413	97/9376	0.936172337185792	FOS/CALM1/RPS6KA5/ADCY5	-0.135637003792657
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	2/413	48/9376	0.94592413236481	HMGCS2/AACS	-0.080623901814997
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/413	23/9376	0.987051268554585	GPT2	-0.0133459545162609
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/413	23/9376	0.987051268554585	B4GALT1	-0.0133459545162609
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/413	23/9376	0.987051268554585	HMGCS2	-0.0133459545162609
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	3/413	75/9376	0.908087167070218	CGA/ATF6B/ADCY5	-0.171544155961694
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	2/413	50/9376	0.908087167070218	SDC1/HBA1	-0.139877355987874
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	3/413	78/9376	0.873160737567517	FOS/NFKBIA/NCF4	-0.241457224492533
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	4/413	104/9376	0.873160737567517	DGKG/DGKZ/LPCAT3/PLPP5	-0.27920142590677
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	2/413	53/9376	0.856686006670017	DNM2/RAB11A	-0.224585987464388
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/413	26/9376	0.873160737567517	HES1	-0.139017201712274
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	2/413	54/9376	0.840821450990943	HES1/CENPX	-0.251802964044126
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	2/413	54/9376	0.840821450990943	CGA/HLA-C	-0.251802964044126
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	4/413	108/9376	0.840821450990943	RANBP2/UPF3B/XPO4/RBM8A	-0.357139077567296
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	5/413	134/9376	0.847096237938636	CALM1/ADM/BRAF/MYL6/ADCY5	-0.382667477775559
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	3/413	83/9376	0.820560693135739	GSDMD/NFKBIA/IRF3	-0.352462263906286
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/413	29/9376	0.782833764715705	CALM1	-0.251413819573906
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	3/413	86/9376	0.791936482910074	SLC2A1/ATF6B/ADCY5	-0.416074662846662
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	3/413	86/9376	0.791936482910074	ACTG1/DMD/LMNA	-0.416074662846662
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	3/413	88/9376	0.773937926480299	SERPINE1/PROCR/CFB	-0.457342862112065
NA	NA	hsa04981	Folate transport and metabolism	1/413	31/9376	0.732328360540498	MTHFS	-0.32042583064315
Organismal Systems	Digestive system	hsa04978	Mineral absorption	2/413	61/9376	0.744333743500179	SLC26A6/HMOX1	-0.430012288069296
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	4/413	116/9376	0.782833764715705	SHANK2/GRIK1/ADCY5/DLGAP1	-0.50518421222187
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/413	32/9376	0.709443099273608	ATG4B	-0.353405850233632
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/413	32/9376	0.709443099273608	MAPK10	-0.353405850233632
Human Diseases	Substance dependence	hsa05032	Morphine addiction	3/413	91/9376	0.748423489343586	ADCY5/PDE7A/ADORA1	-0.517647114094207
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	2/413	63/9376	0.720704100849379	CCNH/DDB1	-0.477445712998597
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/413	63/9376	0.720704100849379	GADD45G/GADD45B	-0.477445712998597
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	9/413	254/9376	0.804407923585823	FLT1/CALM1/FGFR1/SLC25A5/CHRM2/SLC25A6/NFATC3/VEGFB/MST1	-0.678355026465607
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/413	37/9376	0.61357241018258	GPT2	-0.505536789877758
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/413	37/9376	0.61357241018258	HBA1	-0.505536789877758
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/413	38/9376	0.597425767809354	BLNK	-0.533758498132412
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	3/413	100/9376	0.681065375302663	CXCL1/TNFRSF1B/CCL28	-0.688264336076101
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/413	39/9376	0.582107158378345	HLA-C	-0.561341979511729
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	3/413	102/9376	0.667711152257513	RAB11A/RAC1/ADCY5	-0.72429630837733
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	3/413	103/9376	0.661228519711324	PPP2R2B/UPF3B/RBM8A	-0.742077544831275
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/413	41/9376	0.553711687237938	MAOA	-0.614729771877458
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	1/413	41/9376	0.553711687237938	RAD51B	-0.614729771877458
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/413	44/9376	0.515958617653533	SMUG1	-0.690804935171983
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	1/413	44/9376	0.515958617653533	HLA-C	-0.690804935171983
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/413	45/9376	0.504492870594565	HLA-C	-0.715197578767547
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/413	46/9376	0.493525634277292	HMOX1	-0.739144805264148
NA	NA	hsa04082	Neuroactive ligand signaling	6/413	199/9376	0.684487814374536	P2RY14/GRIK1/P2RY6/CHRM2/ADCY5/ADORA1	-0.965664520500607
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	2/413	83/9376	0.547040462090493	BCORL1/HDAC2	-0.889722251938369
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	1/413	50/9376	0.454043583535109	CCL28	-0.830862650899521
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	4/413	149/9376	0.60945447454377	MAPK10/NDUFS2/NDUFA6/ADCY5	-1.03149827518094
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	1/413	51/9376	0.445140768171675	GDPD3	-0.852859418475694
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	2/413	87/9376	0.521889176477137	UQCRC1/TPM4	-0.96169572633895
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	5/413	181/9376	0.627132021457333	CALM1/MAPK10/PLK3/TCIRG1/IRAK2	-1.08730772789896
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	2/413	89/9376	0.510161329814729	GPHN/ADCY5	-0.996653769738454
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	1/413	56/9376	0.405396056727776	CSNK1E	-0.957960954753063
Organismal Systems	Digestive system	hsa04970	Salivary secretion	2/413	93/9376	0.488218907026999	CALM1/ADCY5	-1.06467119024969
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	2/413	100/9376	0.454043583535109	MME/IL11RA	-1.1781797942487
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	1/413	63/9376	0.36035205042469	CBR1	-1.09345383259057
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	2/413	103/9376	0.440819013140882	COL27A1/MME	-1.22488366934297
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	1/413	66/9376	0.343972411769022	STAT3	-1.14802989259777
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/413	68/9376	0.333855576128757	RDH13	-1.18339200739816
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	4/413	183/9376	0.496222495666786	NOP56/NVL/MDN1/NOP10	-1.47730324315786
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	10/413	370/9376	0.61357241018258	CGA/LEP/P2RY14/CRH/GRIK1/ADM/P2RY6/LHB/CHRM2/ADORA1	-1.62793470883144
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	1/413	78/9376	0.291053579189172	PFKL	-1.34958396792963
Genetic Information Processing	Translation	hsa03010	Ribosome	3/413	222/9376	0.30678620509129	RPL10A/MRPL55/RPS9	-2.24373827035023
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	1/413	143/9376	0.158756497739549	SSB	-2.17596692398024
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/413	449/9376	0.0505616462733974	CALM1	-4.4255896272538