category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	14/153	232/9376	3.69799414018481	PDGFD/ITGB8/PDGFC/DIAPH2/MYH10/ITGAV/WASL/VAV3/SCIN/FGFR2/PIK3R1/ITGA6/ITGB1/RRAS2	5.35935018432734
NA	NA	hsa04518	Integrin signaling	11/153	154/9376	4.37721755368814	PDGFD/FRAS1/ITGB8/PDGFC/ITGAV/FREM2/PIK3R1/ITGA6/FBN1/ITGB1/CDH1	5.44254575365128
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	8/153	86/9376	5.70056239550084	ITGB8/SNTB1/ITGAV/DMD/CACNA2D3/ITGA6/SGCE/ITGB1	5.64009526821713
NA	NA	hsa04517	IgSF CAM signaling	15/153	299/9376	3.07429995409535	RAPGEF2/EPB41L3/RASA1/LMO7/SRGAP1/IL1RAPL2/PRKCI/MYH10/WASL/VAV3/CD2AP/PIK3R1/APP/ITGB1/CDH1	4.69495283196283
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	8/153	99/9376	4.95200369710174	ITGB8/SNTB1/ITGAV/DMD/CACNA2D3/ITGA6/SGCE/ITGB1	5.09127329834886
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	8/153	105/9376	4.66903205726735	ITGB8/SNTB1/ITGAV/DMD/CACNA2D3/ITGA6/SGCE/ITGB1	4.86942986032341
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	12/153	233/9376	3.15610536059918	FBN2/ITGB8/FMNL2/DIAPH2/SNTB1/MYH10/ITGAV/DMD/ITGA6/FBN1/SGCE/ITGB1	4.29238658855743
Human Diseases	Cancer: specific types	hsa05218	Melanoma	6/153	73/9376	5.03679828095622	PDGFD/CDK6/PDGFC/PIK3R1/MDM2/CDH1	4.45945942821025
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	10/153	212/9376	2.89061536564311	PDGFD/RAPGEF2/PDGFC/PRKCI/VAV3/FGFR2/PIK3R1/ITGB1/MAGI3/CDH1	3.58611178177272
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	6/153	89/9376	4.13130645516634	FRAS1/ITGB8/ITGAV/FREM2/ITGA6/ITGB1	3.82276941905414
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	12/153	300/9376	2.45124183006536	PDGFD/RAPGEF2/RASA1/MAP4K3/PPP3CA/ERBB4/PDGFC/CACNA2D3/FGFR2/ATF2/MAP2K4/RRAS2	3.29039791181854
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	9/153	203/9376	2.71689365401333	PDGFD/ITGB8/ARHGAP5/PDGFC/ITGAV/VAV3/PIK3R1/ITGA6/ITGB1	3.18515790075055
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	13/153	362/9376	2.2007005380421	PDGFD/ITGB8/CDK6/ERBB4/PDGFC/ITGAV/PKN2/FGFR2/ATF2/PIK3R1/ITGA6/MDM2/ITGB1	3.00071993120548
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	3/153	24/9376	7.66013071895425	EXTL2/HS6ST2/EXT1	4.20757023572377
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	12/153	333/9376	2.20832597303186	PATJ/ITGB8/CDK6/MAML3/RBPJ/UBE3A/PRKCI/ITGAV/PIK3R1/ITGA6/MDM2/ITGB1	2.89164657627165
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	5/153	78/9376	3.92827216356628	WASL/CD2AP/PIK3R1/ITGB1/CDH1	3.3447157772368
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	7/153	157/9376	2.73227592523209	CDK6/PPP3CA/MRE11/PIK3R1/MDM2/FBXW11/RRAS2	2.81916332990246
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	3/153	32/9376	5.74509803921569	SUCLG2/BCKDHB/ECHDC1	3.46297226624475
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	5/153	93/9376	3.29467987912011	CDK6/ITGAV/PIK3R1/ITGA6/ITGB1	2.86427462733969
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	8/153	204/9376	2.40317826476996	ERBB4/FRS2/ITGAV/VAV3/PIK3R1/MDM2/ITGB1/RRAS2	2.60970344477514
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	8/153	205/9376	2.3914554439662	CDK6/RBPJ/UBE3A/IL6ST/SCIN/ATF2/PIK3R1/MDM2	2.59437730973917
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	7/153	169/9376	2.53826816722744	WDFY3/ATG5/ATG4C/EIF2AK4/PIK3R1/RRAS2/C9orf72	2.59903173800289
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	9/153	254/9376	2.17137563686892	PDGFD/ATP2B1/ASPH/PPP3CA/ERBB4/PDGFC/PHKB/FGFR2/EDNRB	2.43760459935798
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	6/153	138/9376	2.6643932935493	PKN2/WASL/VAV3/PIK3R1/MAP2K4/ITGB1	2.5368907838211
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	3/153	39/9376	4.71392659627954	AHCYL2/MTR/ALDH7A1	2.99334785806745
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	5/153	106/9376	2.89061536564311	PDGFD/PDGFC/FGFR2/PIK3R1/MDM2	2.52122438007858
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	4/153	80/9376	3.0640522875817	PDGFD/PDGFC/FGFR2/PIK3R1	2.38788210063431
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	6/153	157/9376	2.34195079305608	PATJ/RASSF6/PRKCI/FRMD6/FBXW11/CDH1	2.18393525604782
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	6/153	160/9376	2.29803921568627	NRXN3/ITGB8/ITGAV/ITGA6/ITGB1/CDH1	2.13290651559402
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	3/153	56/9376	3.28291316526611	GLI3/FBXW11/LRP2	2.20683924844261
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	4/153	93/9376	2.63574390329609	LMO7/FER/WASL/CDH1	2.04177489054949
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	7/153	227/9376	1.88972387780369	CDK6/PPP3CA/ITGAV/AKAP13/ATF2/PIK3R1/MDM2	1.74773913153949
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	4/153	99/9376	2.47600184855087	PDGFD/PDGFC/DGKD/PIK3R1	1.90149842353428
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	3/153	62/9376	2.9652118912081	TLE4/MAML3/RBPJ	1.99955042428251
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	6/153	184/9376	1.99829497016198	RASA1/SRGAP1/PPP3CA/SEMA3C/PIK3R1/ITGB1	1.76140017806501
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/153	29/9376	4.22627901735407	RASSF6/FRMD6	2.24109388470423
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	5/153	144/9376	2.1278140885984	IL6ST/FGFR2/JARID2/SMARCAD1/PIK3R1	1.75657263560126
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	4/153	105/9376	2.33451602863368	PPP3CA/PIK3R1/MDM2/RRAS2	1.77112985045677
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	2/153	32/9376	3.83006535947712	ATG5/ATG4C	2.06538153069418
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	5/153	149/9376	2.05641093126289	PDGFD/PDGFC/DGKD/PIK3R1/RRAS2	1.674137057089
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	3/153	69/9376	2.6643932935493	VAV3/PIK3R1/MAP2K4	1.78719069610915
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/153	34/9376	3.60476739715494	NR1D2/FBXW11	1.95967351732441
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	3/153	70/9376	2.62633053221289	SNTB1/DMD/SGCE	1.75902317212016
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	6/153	201/9376	1.82928494780997	KDM6A/SUPT3H/PBX1/MDM2/ETV6/BMP2K	1.53071389389671
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	5/153	157/9376	1.95162566088006	ABCA1/ITGAV/PBX1/ATP11B/ANO6	1.54870718219318
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	3/153	73/9376	2.51839914047811	EML4/CDK6/PIK3R1	1.67737867773455
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	6/153	205/9376	1.79359158297465	CDK6/RBPJ/PSMD14/PIK3R1/MDM2/MAP2K4	1.47965643096757
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	7/153	253/9376	1.69552300498592	ATG5/WASL/NAIP/PIK3R1/MDM2/FBXW11/ITGB1	1.4444355601281
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	4/153	116/9376	2.11313950867703	ARHGAP5/VAV3/PIK3R1/ITGB1	1.55370422960696
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	3/153	75/9376	2.45124183006536	TOP2B/PIK3R1/MDM2	1.62517767062484
Human Diseases	Cancer: specific types	hsa05214	Glioma	3/153	76/9376	2.41898864809082	CDK6/PIK3R1/MDM2	1.59970348993276
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	3/153	77/9376	2.38757321110262	CDK6/PIK3R1/MDM2	1.57462954043799
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	6/153	216/9376	1.70225127087872	ABCA1/MIB1/PPP3CA/VAV3/PIK3R1/MAP2K4	1.34482855460028
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	2/153	41/9376	2.98931930495776	MDM2/CDH1	1.64412379069096
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	5/153	170/9376	1.80238369857747	PATJ/RAPGEF2/PRKCI/MYH10/ITGB1	1.35977271228677
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	2/153	42/9376	2.91814503579209	ATG5/SLC40A1	1.6046024035216
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	2/153	44/9376	2.78550207961973	MNAT1/TAF4B	1.52895457518215
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	4/153	130/9376	1.88557063851181	ATF2/PIK3R1/MAP2K4/EDNRB	1.30952317835922
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	6/153	226/9376	1.62693041818497	PDE4B/ATP2B1/VAV3/GLI3/PIK3R1/RRAS2	1.22873509809391
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	3/153	86/9376	2.13771089831281	ERBB4/PIK3R1/MAP2K4	1.3651127916768
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	5/153	178/9376	1.72137768965264	LGR5/RNF43/TLE4/PPP3CA/FBXW11	1.25147233746807
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	3/153	90/9376	2.04270152505447	ATG5/ATF2/PIK3R1	1.28015386890204
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	3/153	90/9376	2.04270152505447	EML4/PPP3CA/PIK3R1	1.28015386890204
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	2/153	48/9376	2.55337690631808	BCKDHB/ALDH7A1	1.38962763950985
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	3/153	91/9376	2.02025425554837	PPP3CA/VAV3/PIK3R1	1.25960218792327
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	4/153	138/9376	1.77626219569954	CPEB2/PPP3CA/SPDYE5/FBXW11	1.18318934456855
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	5/153	187/9376	1.63853063507043	ERBIN/PKN2/ATG5/NAIP/NEK7	1.13596163788811
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/153	13/9376	4.71392659627954	MRE11	1.72580900066015
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	6/153	238/9376	1.5449003130664	PDGFD/RASA1/PDGFC/FGFR2/PIK3R1/RRAS2	1.09666809376932
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	3/153	93/9376	1.97680792747206	MAML3/PPP3CA/RBPJ	1.21927515375928
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	4/153	142/9376	1.7262266408911	UBE3A/PIAS1/MDM2/FBXW11	1.12309543734736
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	2/153	52/9376	2.35696329813977	ABCA1/LRP2	1.26375791934204
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	4/153	144/9376	1.70225127087872	PUM2/RBPJ/PSMD14/PIK3R1	1.09375771965642
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	3/153	98/9376	1.87595038015206	INPP4B/DGKD/PIK3R1	1.12269194957651
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	3/153	98/9376	1.87595038015206	VAV3/SCIN/PIK3R1	1.12269194957651
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	5/153	196/9376	1.56329198346005	CDK6/PPP3CA/IL6ST/PIK3R1/MAP2K4	1.0264446015565
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/153	15/9376	4.08540305010893	TPK1	1.54025157199148
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	3/153	99/9376	1.85700138641315	ESR2/PIK3R1/MDM2	1.10405470483063
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	2/153	54/9376	2.26966836117163	AHCYL2/MTR	1.20511329437004
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	5/153	200/9376	1.53202614379085	SEC24B/MYH10/WASL/NAIP/ITGB1	0.979527241822093
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/153	17/9376	3.60476739715494	MTR	1.38443934654632
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/153	17/9376	3.60476739715494	MYH10	1.38443934654632
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	4/153	155/9376	1.58144634197765	PLA2R1/ITGAV/COLEC12/ITGB1	0.940116618873135
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	2/153	59/9376	2.07732358480115	PIK3R1/CDH1	1.06912719063402
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	3/153	107/9376	1.71816016126077	PPP3CA/PHKB/ATF2	0.962259055413995
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	2/153	60/9376	2.04270152505447	PPP3CA/PIK3R1	1.04355692237505
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/153	18/9376	3.40450254175744	MTR	1.31511951384249
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	4/153	158/9376	1.5514188797882	CDK6/STAG2/NIPBL/MDM2	0.900299631770154
Organismal Systems	Digestive system	hsa04978	Mineral absorption	2/153	61/9376	2.00921461480767	ATP2B1/SLC40A1	1.01847944447257
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	3/153	110/9376	1.67130124777184	CPEB2/SPDYE5/PIK3R1	0.912142934380145
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	2/153	62/9376	1.97680792747206	ATG5/PIK3R1	0.993875884100513
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/153	19/9376	3.22531819745442	BCKDHB	1.25053500897847
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	4/153	166/9376	1.47665170485865	ATP2B1/PPP3CA/ATF2/EDNRB	0.798032592809999
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	2/153	65/9376	1.88557063851181	DGKD/ALDH7A1	0.922734955690273
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	2/153	65/9376	1.88557063851181	PBX1/ATF2	0.922734955690273
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	2/153	65/9376	1.88557063851181	ESR2/PIK3R1	0.922734955690273
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	3/153	115/9376	1.59863597612958	PDE4B/AKAP13/ATF2	0.831913248002598
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	3/153	116/9376	1.58485463150778	HOMER1/GRIK2/PPP3CA	0.816331742423579
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/153	22/9376	2.78550207961973	ALDH7A1	1.07986202118509
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	3/153	119/9376	1.5449003130664	ATF2/PIK3R1/MAP2K4	0.770460992026952
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	2/153	69/9376	1.77626219569954	PPP3CA/ATF2	0.833534104752971
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/153	23/9376	2.6643932935493	ENPEP	1.02929451226337
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	3/153	122/9376	1.50691096110575	PPP3CA/VAV3/PIK3R1	0.725842007906297
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	3/153	122/9376	1.50691096110575	ITGAV/PIK3R1/MDM2	0.725842007906297
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	3/153	122/9376	1.50691096110575	ATF2/PIK3R1/MAP2K4	0.725842007906297
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	2/153	71/9376	1.7262266408911	ESR2/PIK3R1	0.791112800177714
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	2/153	71/9376	1.7262266408911	FGFR2/PIK3R1	0.791112800177714
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	2/153	73/9376	1.67893276031874	TRIM5/MDFIC	0.750018427575983
Organismal Systems	Immune system	hsa04611	Platelet activation	3/153	126/9376	1.45907251789605	PRKCI/PIK3R1/ITGB1	0.6681761199194
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	2/153	75/9376	1.63416122004357	CDK6/MDM2	0.710167411825913
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	2/153	75/9376	1.63416122004357	ATF2/LRP2	0.710167411825913
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	2/153	77/9376	1.59171547406842	CDK6/PIK3R1	0.671483607169099
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	2/153	78/9376	1.57130886542651	CNOT2/PABPC1	0.652557436307461
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/153	28/9376	2.18860877684407	GCNT2	0.811248386286945
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	3/153	133/9376	1.38227922748047	HOMER1/PIK3R1/MDM2	0.571867338368071
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	3/153	133/9376	1.38227922748047	PPP3CA/VAV3/PIK3R1	0.571867338368071
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	5/153	250/9376	1.22562091503268	DNAJC6/PRKCI/WASL/FGFR2/MDM2	0.465698005179119
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/153	30/9376	2.04270152505447	SUCLG2	0.736720911088418
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/153	30/9376	2.04270152505447	PGAP1	0.736720911088418
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/153	30/9376	2.04270152505447	MTR	0.736720911088418
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	3/153	138/9376	1.33219664677465	PRKCI/PHKB/PIK3R1	0.506338624942269
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	2/153	83/9376	1.47665170485865	TEX10/JARID2	0.561768621892335
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	2/153	83/9376	1.47665170485865	FAR1/CROT	0.561768621892335
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	3/153	139/9376	1.3226124982367	ESR2/ATF2/PIK3R1	0.493535464699005
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/153	31/9376	1.97680792747206	ALDH7A1	0.701609755295679
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/153	31/9376	1.97680792747206	ALDH7A1	0.701609755295679
NA	NA	hsa04981	Folate transport and metabolism	1/153	31/9376	1.97680792747206	MTR	0.701609755295679
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	3/153	142/9376	1.29466998066832	ITGAV/PIK3R1/MAP2K4	0.455701419058043
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	2/153	87/9376	1.40875967245136	ASPH/CACNA2D3	0.493331034140037
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/153	33/9376	1.85700138641315	BCKDHB	0.635170865473123
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	2/153	89/9376	1.37710215172211	PDGFD/PDGFC	0.460374796942775
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	3/153	148/9376	1.24218335983042	CDK6/ESR2/PIK3R1	0.382486942810461
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	3/153	150/9376	1.22562091503268	FGFR2/PIK3R1/CDH1	0.358767843311936
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/153	36/9376	1.70225127087872	AGL	0.543707840030656
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/153	36/9376	1.70225127087872	GALNT11	0.543707840030656
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/153	36/9376	1.70225127087872	PRIM2	0.543707840030656
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	1/153	37/9376	1.65624447977389	CDH1	0.515123765609127
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	3/153	154/9376	1.19378660555131	ATP2B1/CACNA2D3/ATF2	0.312296276562341
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	4/153	214/9376	1.14544010750718	TRIM5/PPP3CA/PIK3R1/FBXW11	0.277198693582807
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/153	38/9376	1.61265909872721	PIK3R1	0.487392677901939
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	3/153	155/9376	1.18608475648324	CDK6/PBX1/ATF2	0.300872770983186
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	3/153	156/9376	1.17848164906988	CDK6/PIAS1/PIK3R1	0.289524725061473
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	2/153	98/9376	1.25063358676804	ATP2B1/ATF2	0.321233161756396
NA	NA	hsa04081	Hormone signaling	4/153	219/9376	1.11928850687916	ESR2/ITGAV/PIK3R1/SLC40A1	0.2300590394713
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/153	41/9376	1.49465965247888	ALDH7A1	0.408824114313169
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	1/153	41/9376	1.49465965247888	MRE11	0.408824114313169
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	3/153	163/9376	1.12787200769879	ATF2/PIK3R1/MAP2K4	0.21211139486295
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	4/153	224/9376	1.09430438842204	PPP3CA/ATF2/PIK3R1/MAP2K4	0.183989549351092
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/153	42/9376	1.45907251789605	ALDH7A1	0.38403189115599
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	2/153	103/9376	1.18992321847833	COL14A1/COL21A1	0.249621387625168
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	2/153	103/9376	1.18992321847833	PIK3R1/MAP2K4	0.249621387625168
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/153	43/9376	1.42514059887521	ALDH7A1	0.359874789734935
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/153	43/9376	1.42514059887521	ABCA1	0.359874789734935
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	2/153	104/9376	1.17848164906988	ETNK1/DGKD	0.235732128387086
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	2/153	105/9376	1.16725801431684	RRAS2/MTX2	0.221979845523455
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	1/153	44/9376	1.39275103980986	MAN1A1	0.336319126188154
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	3/153	168/9376	1.09430438842204	IL6ST/PIAS1/PIK3R1	0.158854359484981
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/153	45/9376	1.36180101670298	ABCA1	0.313333762992411
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	1/153	46/9376	1.33219664677465	PSMD14	0.290889863316087
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	2/153	109/9376	1.12442285782815	PIK3R1/MAP2K4	0.168282551837786
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	2/153	109/9376	1.12442285782815	PPP3CA/IL6ST	0.168282551837786
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	1/153	47/9376	1.30385203726881	ALDH7A1	0.268960673912733
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/153	47/9376	1.30385203726881	PIK3R1	0.268960673912733
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/153	48/9376	1.27668845315904	PIK3R1	0.247521332703717
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	4/153	238/9376	1.02993354204427	RPS12/IL6ST/RPS24/PIK3R1	0.0602443414075473
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	2/153	112/9376	1.09430438842204	ITGA6/ITGB1	0.129311422845419
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	1/153	49/9376	1.25063358676804	GALNT11	0.226548697787306
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/153	49/9376	1.25063358676804	ATF2	0.226548697787306
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/153	50/9376	1.22562091503268	ALDH7A1	0.206021195100143
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	4/153	248/9376	0.988403963736032	EXOC4/WASL/NAIP/MAP2K4	-0.0238365193268222
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	1/153	53/9376	1.15624614625725	ATP2B1	0.146914498321107
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	2/153	120/9376	1.02135076252723	FRS2/PIK3R1	0.0303170953399069
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	1/153	56/9376	1.09430438842204	MAN1A1	0.0911618667045822
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	1/153	56/9376	1.09430438842204	NAIP	0.0911618667045822
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	2/153	128/9376	0.957516339869281	PDE4B/ADK	-0.0623301611028094
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1/153	59/9376	1.03866179240058	PIK3R1	0.0383676493091283
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	2/153	133/9376	0.921519484986977	PPP3CA/ATF2	-0.117402254708036
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	1/153	63/9376	0.972715011930698	ALDH7A1	-0.0279862359138793
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/153	63/9376	0.972715011930698	MNAT1	-0.0279862359138793
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	1/153	63/9376	0.972715011930698	GLI3	-0.0279862359138793
NA	NA	hsa04519	Cadherin signaling	6/153	404/9376	0.910114540865851	ERBIN/RERE/DSC3/VAV3/RRAS2/CDH1	-0.237865107827628
Human Diseases	Infectious disease: viral	hsa05162	Measles	2/153	136/9376	0.901191849288735	CDK6/PIK3R1	-0.149493217435407
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	4/153	275/9376	0.891360665478312	PPP3CA/PSMD14/ATF2/PIK3R1	-0.235507171046657
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	1/153	67/9376	0.914642473904985	ALDH7A1	-0.0903073201743677
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	1/153	67/9376	0.914642473904985	PPP3CA	-0.0903073201743677
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	2/153	140/9376	0.875443510737628	RRAS2/CDH1	-0.191242170361251
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	1/153	68/9376	0.901191849288735	PIK3R1	-0.105320833998177
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	2/153	142/9376	0.863113320445549	PPP3CA/PIK3R1	-0.211692599231275
Organismal Systems	Endocrine system	hsa04924	Renin secretion	1/153	69/9376	0.888131097849768	PPP3CA	-0.120122486603204
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	1/153	70/9376	0.875443510737628	PIK3R1	-0.134719078631777
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	2/153	144/9376	0.851125635439361	MAP2K4/ALDH7A1	-0.231872112233264
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	1/153	71/9376	0.863113320445549	MAP2K4	-0.149117091375873
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	3/153	217/9376	0.847203397488028	ESR2/ATF2/PIK3R1	-0.293301837881904
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	1/153	72/9376	0.851125635439361	ATG5	-0.163322706209826
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	1/153	75/9376	0.817080610021787	MTR	-0.20484284697301
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	2/153	154/9376	0.795857737034208	PPP3CA/CACNA2D3	-0.328984908073776
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	1/153	78/9376	0.785654432713256	INPP4B	-0.244828677335653
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	1/153	78/9376	0.785654432713256	ITGB1	-0.244828677335653
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	1/153	78/9376	0.785654432713256	ITGB1	-0.244828677335653
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	1/153	79/9376	0.775709439894101	SYT1	-0.257838861540266
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	3/153	235/9376	0.782311222361285	COA1/FRS2/ATF2	-0.435279653001689
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	1/153	85/9376	0.720953479430988	ADK	-0.332851174525843
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	1/153	86/9376	0.712570299437604	ATF2	-0.344880198939324
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	1/153	87/9376	0.704379836225678	PIK3R1	-0.356783241929985
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	2/153	170/9376	0.720953479430988	CDK6/PIK3R1	-0.472890768844148
Human Diseases	Substance dependence	hsa05032	Morphine addiction	1/153	91/9376	0.673418085182791	PDE4B	-0.40319684255453
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	2/153	173/9376	0.708451395972647	CDK6/PIK3R1	-0.498499303832653
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	4/153	323/9376	0.75889839940104	TP63/CDK6/PIK3R1/MDM2	-0.56793723637233
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	3/153	250/9376	0.735372549019608	AP3B1/VPS13C/DMXL1	-0.546210337013099
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	2/153	174/9376	0.704379836225678	SEC24B/MAN1A1	-0.506947297525321
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	1/153	93/9376	0.658935975824021	MAP2K4	-0.425724319821124
Organismal Systems	Digestive system	hsa04970	Salivary secretion	1/153	93/9376	0.658935975824021	ATP2B1	-0.425724319821124
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	1/153	94/9376	0.651926018634404	USP25	-0.436827483714692
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	2/153	181/9376	0.677138627089878	PLA2R1/PPP3CA	-0.564904142053681
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	1/153	99/9376	0.619000462137717	PIK3R1	-0.490832732576657
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	1/153	100/9376	0.61281045751634	IL6ST	-0.501347089833815
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	1/153	100/9376	0.61281045751634	ITGA6	-0.501347089833815
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	1/153	101/9376	0.606743027243901	EDNRB	-0.511770689203035
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	1/153	101/9376	0.606743027243901	PIK3R1	-0.511770689203035
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	1/153	102/9376	0.60079456619249	ATP2B1	-0.522105458236583
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	1/153	103/9376	0.594961609239165	PABPC1	-0.532353263351637
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	1/153	103/9376	0.594961609239165	PIK3R1	-0.532353263351637
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	2/153	193/9376	0.635036743540249	VAV3/PIK3R1	-0.659828020737595
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	1/153	109/9376	0.562211428914073	PIK3R1	-0.59211128239406
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	1/153	110/9376	0.557100415923945	PIK3R1	-0.601797967150788
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	1/153	110/9376	0.557100415923945	FBN1	-0.601797967150788
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	1/153	115/9376	0.532878658709861	PIK3R1	-0.649149813475112
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	1/153	115/9376	0.532878658709861	APP	-0.649149813475112
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	1/153	116/9376	0.528284877169259	SUCLG2	-0.65841323194318
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	1/153	117/9376	0.523769621808838	EPC2	-0.667610614809894
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	4/153	368/9376	0.666098323387326	PPP3CA/ERBB4/PSMD14/C9orf72	-0.841634577549853
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	1/153	122/9376	0.502303653701918	PIK3R1	-0.712647669990436
NA	NA	hsa04382	Cornified envelope formation	2/153	217/9376	0.564802264992018	KAZN/ITGA6	-0.835387000898014
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	1/153	125/9376	0.490248366013072	PIK3R1	-0.738949129531634
Genetic Information Processing	Translation	hsa03010	Ribosome	2/153	222/9376	0.552081493257964	RPS12/RPS24	-0.869891904390032
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	4/153	388/9376	0.631763358264268	PPP3CA/PSMD14/PIK3R1/APP	-0.954127869282422
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	2/153	227/9376	0.539921107943912	PIK3R1/MAP2K4	-0.90376115927865
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	1/153	134/9376	0.457321236952492	MYH10	-0.814905957515989
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	1/153	137/9376	0.447306903296598	PIK3R1	-0.839319067531033
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	1/153	154/9376	0.397928868517104	TPK1	-0.970266092709894
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	1/153	157/9376	0.390325132176013	PIK3R1	-0.992205113225386
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	1/153	158/9376	0.387854719947051	PIK3R1	-0.999447408172148
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	1/153	180/9376	0.340450254175744	PIK3R1	-1.15074627528284
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	4/153	480/9376	0.510675381263617	PPP3CA/PSMD14/APP/C9orf72	-1.41747545453797
Human Diseases	Substance dependence	hsa05034	Alcoholism	1/153	191/9376	0.320843171474524	ATF2	-1.22135643300258
Cellular Processes	Cell motility	hsa04814	Motor proteins	1/153	194/9376	0.315881679132134	MYH10	-1.2401056641741
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	1/153	195/9376	0.314261773085303	PIK3R1	-1.24630954589336
NA	NA	hsa04082	Neuroactive ligand signaling	1/153	199/9376	0.307944953525799	GRIK2	-1.2709019952439
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	2/153	308/9376	0.397928868517104	PSMD14/TAF4B	-1.38376600051276
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	1/153	205/9376	0.298931930495776	PIK3R1	-1.30714576596143
Genetic Information Processing	Transcription	hsa03040	Spliceosome	1/153	243/9376	0.252185373463514	HNRNPC	-1.52119753344112
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	2/153	370/9376	0.331248895954778	GRIK2/EDNRB	-1.69042011537559
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	1/153	268/9376	0.228660618476246	PSMD14	-1.65004823769002
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	1/153	298/9376	0.205641093126289	IL6ST	-1.79483719766198