category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	4/30	115/9376	10.8707246376812	ITPR2/KCNQ3/JAK2/GNAQ	6.03395951462063
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	4/30	115/9376	10.8707246376812	MEF2A/ITPR2/GNAQ/WNK1	6.03395951462063
Organismal Systems	Nervous system	hsa04730	Long-term depression	3/30	60/9376	15.6266666666667	ITPR2/GNAQ/LYN	6.43931434942786
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	4/30	140/9376	8.92952380952381	MEF2A/ITPR2/GNAQ/SLC8A1	5.35553103557907
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	3/30	66/9376	14.2060606060606	MAF/HLA-DRA/IL21R	6.0996341961807
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	4/30	166/9376	7.53092369477912	MEF2A/ITPR2/GNAQ/SLC8A1	4.80985756533533
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	3/30	78/9376	12.0205128205128	JAK2/FCGR1A/HLA-DRA	5.53716814506204
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	4/30	180/9376	6.94518518518518	JAK2/CCL2/CD74/HLA-DRA	4.56284310199361
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	4/30	181/9376	6.90681399631676	JAK2/FCGR1A/CD74/HLA-DRA	4.54621628311473
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	4/30	193/9376	6.47737478411054	JAK2/GNAQ/CCL2/LYN	4.35604339633315
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	3/30	93/9376	10.0817204301075	JAK2/MAF/HLA-DRA	4.98653423235853
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	3/30	98/9376	9.56734693877551	PTPRC/FCGR1A/LYN	4.83020524512114
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	3/30	109/9376	8.60183486238532	JAK2/HLA-DRA/IL21R	4.52267599229801
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	3/30	122/9376	7.68524590163934	ITPR2/JAK2/GNAQ	4.21081277064041
Organismal Systems	Immune system	hsa04611	Platelet activation	3/30	126/9376	7.44126984126984	ITPR2/GNAQ/LYN	4.12400588779022
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	2/30	51/9376	12.2562091503268	LPCAT2/ENPP2	4.56652878021211
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	2/30	53/9376	11.7937106918239	GNAQ/SLC8A1	4.46441175746503
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	3/30	173/9376	5.41965317919075	JAK2/CCL2/HLA-DRA	3.324144607852
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	2/30	65/9376	9.61641025641026	ITPR2/GNAQ	3.94928304953044
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	2/30	65/9376	9.61641025641026	ITPR2/GNAQ	3.94928304953044
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	2/30	67/9376	9.32935323383085	ITPR2/GNAQ	3.87641748278196
Organismal Systems	Endocrine system	hsa04924	Renin secretion	2/30	69/9376	9.05893719806763	ITPR2/GNAQ	3.80654384962513
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	2/30	70/9376	8.92952380952381	HLA-DRA/DTNA	3.77266272043567
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	2/30	75/9376	8.33422222222222	ITPR2/GNAQ	3.61287762458668
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	3/30	196/9376	4.78367346938775	ITPR2/JAK2/LYN	3.03286948900518
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	2/30	76/9376	8.22456140350877	ITPR2/GNAQ	3.58269787135163
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	3/30	201/9376	4.66467661691542	BMP2K/FCGR1A/MAF	2.97552789853028
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	2/30	82/9376	7.62276422764228	CD74/HLA-DRA	3.41254403095488
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	2/30	86/9376	7.26821705426357	SLC8A1/DTNA	3.30840579252513
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	3/30	216/9376	4.34074074074074	JAK2/CCL2/LYN	2.81420214250875
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	2/30	89/9376	7.02322097378277	ITPR2/GNAQ	3.23459159848844
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	3/30	227/9376	4.13039647577093	ITPR2/GNAQ/CCL2	2.70494748517508
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	2/30	93/9376	6.72114695340502	ITPR2/GNAQ	3.14133157379852
Organismal Systems	Digestive system	hsa04970	Salivary secretion	2/30	93/9376	6.72114695340502	ITPR2/GNAQ	3.14133157379852
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	2/30	95/9376	6.57964912280702	CCL2/HLA-DRA	3.09673956356544
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	2/30	98/9376	6.37823129251701	ITPR2/GNAQ	3.03220602413274
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	2/30	99/9376	6.31380471380471	ITPR2/GNAQ	3.01129141460271
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	2/30	99/9376	6.31380471380471	FCGR1A/HLA-DRA	3.01129141460271
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	2/30	99/9376	6.31380471380471	SLC8A1/DTNA	3.01129141460271
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	2/30	100/9376	6.25066666666667	FCGR1A/HLA-DRA	2.99066284790297
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	2/30	101/9376	6.18877887788779	JAK2/CCL2	2.97031335847564
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	2/30	102/9376	6.1281045751634	ITPR2/GNAQ	2.95023621836983
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	2/30	103/9376	6.06860841423948	GNAQ/CCL2	2.9304249268841
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	2/30	105/9376	5.95301587301587	SLC8A1/DTNA	2.89157496486703
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	2/30	107/9376	5.8417445482866	ITPR2/GNAQ	2.85371565160558
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	3/30	254/9376	3.69133858267717	ITPR2/GNAQ/SLC8A1	2.46361896704805
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	2/30	112/9376	5.58095238095238	JAK2/HLA-DRA	2.76311456842489
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	2/30	115/9376	5.43536231884058	ITPR2/GNAQ	2.71133048959667
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	2/30	116/9376	5.38850574712644	ITPR2/GNAQ	2.69447122450743
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	2/30	133/9376	4.69974937343358	ITPR2/GNAQ	2.43458547412761
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	2/30	134/9376	4.66467661691542	ITPR2/GNAQ	2.42068596068756
NA	NA	hsa04517	IgSF CAM signaling	3/30	299/9376	3.13578595317726	UNC5C/KCNQ3/LYN	2.12645173374129
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	2/30	138/9376	4.52946859903382	GNAQ/CCL2	2.36642782861337
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	2/30	139/9376	4.4968824940048	ITPR2/GNAQ	2.35318647962141
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	2/30	142/9376	4.4018779342723	ITPR2/FCGR1A	2.31420240486886
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	2/30	142/9376	4.4018779342723	MEF2A/CCL2	2.31420240486886
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	2/30	143/9376	4.37109557109557	FCGR1A/HLA-DRA	2.30144734550791
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	2/30	144/9376	4.34074074074074	ITPR2/GNAQ	2.28880871655605
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	2/30	149/9376	4.19507829977629	ITPR2/GNAQ	2.2272950748433
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	2/30	154/9376	4.05887445887446	GNAQ/SLC8A1	2.16841714223013
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	2/30	154/9376	4.05887445887446	ITPR2/GNAQ	2.16841714223013
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	2/30	155/9376	4.03268817204301	FCGR1A/HLA-DRA	2.15693954466868
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	2/30	155/9376	4.03268817204301	ITPR2/GNAQ	2.15693954466868
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	2/30	160/9376	3.90666666666667	PTPRC/HLA-DRA	2.10095797655273
Human Diseases	Immune disease	hsa05310	Asthma	1/30	32/9376	9.76666666666667	HLA-DRA	2.81433923494703
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	2/30	168/9376	3.72063492063492	JAK2/IL21R	2.01593084973291
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/30	36/9376	8.68148148148148	GALNT1	2.61611106315415
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/30	37/9376	8.44684684684685	GNAQ	2.57132204786564
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/30	38/9376	8.22456140350877	PTPRC	2.5281901056502
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/30	39/9376	8.01367521367521	HLA-DRA	2.48660986465192
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	2/30	187/9376	3.34260249554367	ITPR2/CCL2	1.83323717874595
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	2/30	195/9376	3.20547008547009	HDAC9/FCGR1A	1.76322145072807
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	1/30	44/9376	7.1030303030303	HLA-DRA	2.29888833578874
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/30	45/9376	6.94518518518518	HLA-DRA	2.26485772928101
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	2/30	205/9376	3.04910569105691	LYN/HLA-DRA	1.68060758977377
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	2/30	205/9376	3.04910569105691	HDAC9/LYN	1.68060758977377
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	1/30	49/9376	6.37823129251701	GALNT1	2.13845395797284
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	1/30	50/9376	6.25066666666667	HLA-DRA	2.10904148406304
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	1/30	50/9376	6.25066666666667	CCL2	2.10904148406304
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	2/30	214/9376	2.9208722741433	ITPR2/GNAQ	1.6104365112197
NA	NA	hsa04081	Hormone signaling	2/30	219/9376	2.85418569254186	JAK2/GNAQ	1.57301206309416
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	1/30	54/9376	5.78765432098765	HLA-DRA	1.99893417811932
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	2/30	233/9376	2.6826895565093	FMNL3/DTNA	1.4735706986306
Organismal Systems	Digestive system	hsa04978	Mineral absorption	1/30	61/9376	5.12349726775956	SLC8A1	1.83051198304072
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	1/30	62/9376	5.04086021505376	TLE4	1.80856837486802
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	2/30	248/9376	2.52043010752688	EXOC4/PTPRC	1.37479474311499
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	1/30	68/9376	4.59607843137255	FCGR1A	1.68612124886079
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	1/30	69/9376	4.52946859903382	LYN	1.66710282732054
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	1/30	70/9376	4.4647619047619	JAK2	1.6484442681894
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	1/30	71/9376	4.4018779342723	JAK2	1.63013318709402
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	1/30	71/9376	4.4018779342723	LYN	1.63013318709402
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	1/30	80/9376	3.90666666666667	JAK2	1.47919538575121
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	1/30	83/9376	3.76546184738956	SFMBT2	1.43371267956906
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	1/30	86/9376	3.63410852713178	GNAQ	1.39029963925308
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	1/30	87/9376	3.59233716475096	SLC8A1	1.37625848078538
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	2/30	298/9376	2.09753914988814	CCL2/IL21R	1.0908535285996
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	1/30	90/9376	3.47259259259259	JAK2	1.33534306756048
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	1/30	91/9376	3.43443223443223	LYN	1.32208935738486
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	1/30	93/9376	3.36057347670251	PTPRJ	1.29612891523851
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	1/30	94/9376	3.32482269503546	CCL2	1.2834127768906
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	1/30	97/9376	3.22199312714777	GNAQ	1.24626778289458
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	1/30	98/9376	3.1891156462585	ITPR2	1.23420680314434
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	1/30	100/9376	3.12533333333333	CCL2	1.21054255448383
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	1/30	101/9376	3.09438943894389	GNAQ	1.19893197893947
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	1/30	103/9376	3.03430420711974	SLC8A1	1.17613657836761
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	1/30	103/9376	3.03430420711974	GNAQ	1.17613657836761
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	1/30	104/9376	3.00512820512821	LPCAT2	1.16494516017985
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	1/30	105/9376	2.97650793650794	LYN	1.15388704853622
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	1/30	105/9376	2.97650793650794	ITPR2	1.15388704853622
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	1/30	116/9376	2.69425287356322	ARHGAP5	1.04024373622943
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	1/30	119/9376	2.62633053221288	CCL2	1.01153413144594
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	1/30	122/9376	2.56174863387978	PTPRC	0.983693223679115
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	1/30	125/9376	2.50026666666667	GNAQ	0.956670766822138
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	2/30	388/9376	1.61099656357388	ITPR2/GNAQ	0.696396333307408
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	1/30	137/9376	2.28126520681265	ITPR2	0.855894449814136
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	1/30	138/9376	2.26473429951691	ITPR2	0.847975370286038
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	1/30	144/9376	2.17037037037037	JAK2	0.801844295378836
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	1/30	157/9376	1.99065817409766	JAK2	0.709194115258733
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	1/30	157/9376	1.99065817409766	ITPR2	0.709194115258733
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	1/30	163/9376	1.91738241308793	JAK2	0.669386661190053
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	1/30	168/9376	1.86031746031746	JAK2	0.637476383054397
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	1/30	169/9376	1.84930966469428	VMP1	0.631224321379275
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	1/30	178/9376	1.75580524344569	TLE4	0.576775197122135
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	1/30	184/9376	1.69855072463768	UNC5C	0.542169682128268
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	2/30	480/9376	1.30222222222222	ITPR2/GNAQ	0.385108410467479
Human Diseases	Substance dependence	hsa05034	Alcoholism	1/30	191/9376	1.63630017452007	HDAC9	0.503352839483593
NA	NA	hsa04082	Neuroactive ligand signaling	1/30	199/9376	1.57051926298157	GNAQ	0.460871510192476
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	1/30	203/9376	1.53957307060755	ARHGAP5	0.440327658533317
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	1/30	204/9376	1.53202614379085	ITPR2	0.435260655704747
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	1/30	212/9376	1.47421383647799	GNAQ	0.395669877911856
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	1/30	217/9376	1.44024577572965	JAK2	0.371735820802104
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	1/30	224/9376	1.3952380952381	HLA-DRA	0.339201823503888
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	1/30	227/9376	1.37679882525698	PTPRJ	0.325588481422237
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	1/30	238/9376	1.31316526610644	CCL2	0.277248922078312
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	1/30	253/9376	1.23530961791831	ITPR2	0.214963378452459
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	1/30	268/9376	1.16616915422886	ITPR2	0.15636504445273
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	1/30	275/9376	1.13648484848485	ITPR2	0.130148632401043
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	1/30	300/9376	1.04177777777778	MAP4K4	0.0416669869353107
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	1/30	308/9376	1.01471861471861	GNAQ	0.0148805819826263
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	1/30	362/9376	0.863351749539595	JAK2	-0.150221799927513
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/30	449/9376	0.696065330363771	SLC8A1	-0.373924587245067