category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
NA	NA	hsa04517	IgSF CAM signaling	12/98	299/9376	3.8397379018497	RASA1/NECTIN3/ARPC5/GRIP1/NRCAM/ANK3/NLGN4Y/RDX/RAPGEF2/NRP1/VAV3/GSK3B	5.12878125259358
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	6/98	89/9376	6.44989681265765	GABRB1/SLC38A1/GABRE/GABRA4/GABARAPL1/GLS	5.30905289124965
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	4/98	56/9376	6.83381924198251	MGAT5/MAN1A2/FUT8/STT3B	4.49997931925362
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	8/98	232/9376	3.2990851513019	PDGFD/DIAPH2/EGFR/PPP1R12B/ARPC5/RDX/NCKAP1/VAV3	3.64420191708624
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	6/98	149/9376	3.85262292836598	PDGFD/EGFR/CYTH3/AGPAT5/PLCB1/DGKI	3.60727070159785
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	3/98	41/9376	7.00049776007964	GABRB1/GABRE/GABRA4	3.95725044985869
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	3/98	44/9376	6.52319109461967	MAN1A2/FUT8/STT3B	3.77398817097273
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	4/98	93/9376	4.11498793065613	NECTIN3/EGFR/ARHGAP29/HEG1	3.10259550734694
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	7/98	253/9376	2.64709203839639	NAIP/EGFR/ARPC5/CYTH3/TAB3/PLCB1/GSK3B	2.72948544671323
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	6/98	200/9376	2.87020408163265	NAIP/ARPC5/CYTH3/TAB3/CLDN1/NCKAP1	2.74757013947967
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/98	21/9376	9.11175898931001	COASY/DPYD	3.82449662619306
NA	NA	hsa04519	Cadherin signaling	9/98	404/9376	2.1313396645787	GABRB1/EGFR/GABRE/ARPC5/GABRA4/PCDH11Y/NCKAP1/VAV3/GSK3B	2.388969228236
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	5/98	169/9376	2.8305760173892	DAPK1/WDFY3/GABARAPL1/IRS2/BIRC6	2.46799082596631
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	5/98	170/9376	2.81392557022809	PRKAG2/ARPC5/RDX/CLDN1/RAPGEF2	2.452900491817
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	4/98	122/9376	3.13683506189361	NOTCH2/NCOA2/PLCB1/GSK3B	2.4415052406609
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	3/98	73/9376	3.93178641319541	TRIM5/MLLT1/NUP153	2.58436433723739
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	6/98	248/9376	2.31468071099408	NAIP/ARPC5/CYTH3/TAB3/KPNA4/NCKAP1	2.15640240575654
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	5/98	187/9376	2.55811415475281	NEK7/NAIP/GABARAPL1/TAB3/PLCB1	2.211859020327
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	4/98	133/9376	2.87739757557158	EGFR/PRKAG2/GABARAPL1/IRS2	2.24102699816828
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	3/98	80/9376	3.58775510204082	PDGFD/EGFR/GSK3B	2.38886496663936
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	5/98	203/9376	2.35648939378707	PDGFD/EGFR/PPP1R12B/VAV3/GSK3B	2.00807632816857
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	5/98	204/9376	2.34493797519008	EGFR/PPP1R12B/ANK3/RDX/VAV3	1.99598286647508
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	3/98	89/9376	3.22494840632882	PDGFD/EGFR/PLCB1	2.16744815095701
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	3/98	90/9376	3.1891156462585	PRKAG2/SESN3/IRS2	2.14460400171921
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	2/98	41/9376	4.66699850671976	DAPK1/EGFR	2.41833795637569
Human Diseases	Substance dependence	hsa05032	Morphine addiction	3/98	91/9376	3.15407041937654	GABRB1/GABRE/GABRA4	2.12207696388936
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	4/98	149/9376	2.56841528557732	GABRB1/GABRE/GABRA4/PLCB1	1.98333205953796
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	5/98	212/9376	2.25644974971121	PDGFD/EGFR/RAPGEF2/PLCB1/VAV3	1.90169999924415
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	5/98	216/9376	2.21466364323507	OLR1/NCF2/PLCB1/VAV3/GSK3B	1.85612261951232
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	4/98	154/9376	2.48502517890273	EGFR/PRKAG2/PPP1R12B/PLCB1	1.90964706931889
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/98	45/9376	4.25215419501134	ABCD3/ABCG2	2.24742280195933
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	4/98	157/9376	2.43754062134408	COX7B2/PRKAG2/IRS2/GSK3B	1.86680749689065
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	3/98	99/9376	2.89919604205318	PDGFD/EGFR/DGKI	1.95233844994415
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	4/98	160/9376	2.39183673469388	NECTIN3/NRCAM/NLGN4Y/CLDN1	1.82493980875531
NA	NA	hsa03272	Virion - Hepatitis viruses	2/98	48/9376	3.98639455782313	EGFR/CLDN1	2.13179297846159
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	5/98	233/9376	2.0530787422265	DIAPH2/FBN2/PDLIM5/ANK3/FBN3	1.67288442828912
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	3/98	106/9376	2.70773969965345	PDGFD/EGFR/GSK3B	1.81721466132442
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	3/98	108/9376	2.65759637188209	NUP153/TNPO1/KPNA4	1.78061137990478
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	5/98	238/9376	2.00994683587721	RASA1/RASAL2/PDGFD/RALGAPA2/EGFR	1.62193298667353
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	3/98	109/9376	2.63321475379142	PRKAG2/IRS2/GSK3B	1.76261902707005
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	2/98	54/9376	3.54346182917611	AMD1/APIP	1.92636707568975
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	4/98	178/9376	2.14996560421922	TBL1XR1/FRZB/PLCB1/GSK3B	1.59191414309011
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	3/98	115/9376	2.49582963620231	EGFR/PLCB1/AKAP13	1.65872199482129
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	3/98	116/9376	2.47431386347643	CLDN1/NCF2/VAV3	1.64204457607875
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	3/98	116/9376	2.47431386347643	SLC38A1/GLS/PLCB1	1.64204457607875
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	6/98	323/9376	1.77721614961774	EGFR/FOXP1/RDX/NOTCH2/IRS2/GLS	1.46089266681395
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	2/98	59/9376	3.24316845382221	EGFR/GSK3B	1.77632054451487
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	4/98	184/9376	2.07985803016859	RASA1/SEMA6A/NRP1/GSK3B	1.52034467662102
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	3/98	122/9376	2.35262629642021	IRS2/PLCB1/GSK3B	1.54548390292657
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/98	14/9376	6.83381924198251	FUT8	2.24493701112254
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	2/98	62/9376	3.0862409479921	PRKAG2/IRS2	1.69380607133521
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	2/98	65/9376	2.94379905808477	AGPAT5/DGKI	1.61614891239907
NA	NA	hsa04082	Neuroactive ligand signaling	4/98	199/9376	1.92308481181417	GABRB1/GABRE/GABRA4/PLCB1	1.35266193739779
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	4/98	201/9376	1.90394963955732	CDK14/MLLT1/AFF1/FUT8	1.33140664488274
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/98	17/9376	5.62785114045618	PCDH11Y	1.96273022300391
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	3/98	134/9376	2.14194334450198	PPP1R12B/PLCB1/CALD1	1.36831304295745
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	2/98	70/9376	2.733527696793	PRKAG2/IRS2	1.49613152028823
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	4/98	205/9376	1.8667994026879	COX7B2/NCF2/PLCB1/GSK3B	1.28961085228479
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	2/98	71/9376	2.69502730669733	PRLR/GSK3B	1.47339494869724
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	2/98	71/9376	2.69502730669733	EGFR/GLS	1.47339494869724
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	3/98	138/9376	2.07985803016859	PRKAG2/IRS2/GSK3B	1.31337491870606
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	3/98	138/9376	2.07985803016859	ARPC5/VAV3/GSK3B	1.31337491870606
Human Diseases	Cancer: specific types	hsa05218	Melanoma	2/98	73/9376	2.62119094213028	PDGFD/EGFR	1.42907683719268
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	3/98	139/9376	2.0648950227573	EGFR/NCOA2/PLCB1	1.29993075087357
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/98	19/9376	5.03544575725027	BCKDHB	1.80955376704998
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	3/98	144/9376	1.99319727891156	PRKAG2/TAB3/GSK3B	1.23435579739108
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	2/98	78/9376	2.45316588173731	CNOT6L/XRN1	1.32446112338937
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	3/98	148/9376	1.93932708218423	EGFR/NOTCH2/GSK3B	1.18376474218719
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	5/98	300/9376	1.59455782312925	RASA1/PDGFD/EGFR/MAP4K3/RAPGEF2	1.07566979466472
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	4/98	227/9376	1.68587611255956	EGFR/PLCB1/AKAP13/GSK3B	1.0750861931049
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/98	23/9376	4.15971606033718	GLS	1.5592221671057
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/98	23/9376	4.15971606033718	GLS	1.5592221671057
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	2/98	83/9376	2.30538480452422	LCOR/PHC3	1.22764025996344
NA	NA	hsa04518	Integrin signaling	3/98	154/9376	1.86376888417705	PDGFD/EGFR/GSK3B	1.11075134729792
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	3/98	155/9376	1.85174456879526	EGFR/PLCB1/GSK3B	1.09889880970752
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	2/98	85/9376	2.25114045618247	GDA/ADK	1.19084652090635
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	3/98	156/9376	1.83987441130298	EGFR/CLDN1/GSK3B	1.08713300327439
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	2/98	86/9376	2.2249644043664	EGFR/GSK3B	1.17283341130286
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/98	86/9376	2.2249644043664	GABRA4/PLCB1	1.17283341130286
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	2/98	87/9376	2.19939010086793	EGFR/GSK3B	1.15506678873565
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	2/98	91/9376	2.10271361291769	VAV3/GSK3B	1.08633549520499
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	2/98	93/9376	2.05749396532807	EGFR/PLCB1	1.05328691439978
Organismal Systems	Digestive system	hsa04970	Salivary secretion	2/98	93/9376	2.05749396532807	TRPV6/PLCB1	1.05328691439978
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	2/98	94/9376	2.03560573165436	TAB3/GSK3B	1.0370724137365
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	4/98	250/9376	1.53077551020408	EGFR/ARPC5/CYTH3/ARAP2	0.874202694052602
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/98	30/9376	3.1891156462585	ABCG2	1.23420680314434
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	2/98	98/9376	1.95251978342357	PLCB1/DGKI	0.974162371462046
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	2/98	98/9376	1.95251978342357	ARPC5/VAV3	0.974162371462046
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	3/98	174/9376	1.64954257565095	MAN1A2/STT3B/RAD23B	0.8888175570049
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	2/98	99/9376	1.93279736136879	EGFR/NOTCH2	0.958898457179775
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/98	31/9376	3.0862409479921	DPYD	1.19571355160042
NA	NA	hsa04981	Folate transport and metabolism	1/98	31/9376	3.0862409479921	ABCG2	1.19571355160042
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	2/98	101/9376	1.89452414629218	PLCB1/GSK3B	0.928896417379386
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/98	32/9376	2.98979591836735	BCKDHB	1.15874694433376
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/98	32/9376	2.98979591836735	GABARAPL1	1.15874694433376
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/98	32/9376	2.98979591836735	BIRC6	1.15874694433376
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/98	33/9376	2.89919604205318	BCKDHB	1.12319479960706
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	2/98	104/9376	1.83987441130298	AGPAT5/DGKI	0.885147811287284
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	2/98	105/9376	1.822351797862	GABARAPL1/USP15	0.87088437193498
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/98	34/9376	2.81392557022809	PRKAG2	1.08895637556743
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	2/98	107/9376	1.78828914743467	PRKAG2/PLCB1	0.842815448145642
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/98	37/9376	2.5857694429123	GLS	0.993258319129365
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/98	37/9376	2.5857694429123	PLCB1	0.993258319129365
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	3/98	193/9376	1.48715237390293	PLCB1/VAV3/GSK3B	0.7027853139766
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	2/98	115/9376	1.66388642413487	GABRB1/PLCB1	0.736182107323106
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	2/98	122/9376	1.56841753094681	PRKAG2/IRS2	0.649462565192246
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	2/98	122/9376	1.56841753094681	VAV3/GSK3B	0.649462565192246
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/98	45/9376	2.12607709750567	KLRD1	0.778183073109052
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	2/98	128/9376	1.49489795918367	GDA/ADK	0.579386309821719
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/98	47/9376	2.03560573165436	IRS2	0.731471348801179
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	2/98	130/9376	1.47189952904239	EGFR/PLCB1	0.556821207112428
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	3/98	217/9376	1.32267469199661	EGFR/NOTCH2/KPNA4	0.494244942022749
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/98	48/9376	1.99319727891156	BCKDHB	0.708978986003173
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/98	48/9376	1.99319727891156	PLCB1	0.708978986003173
NA	NA	hsa04081	Hormone signaling	3/98	219/9376	1.31059547106514	PRLR/IRS2/PLCB1	0.477982571158828
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	2/98	133/9376	1.43869878778579	KLRD1/VAV3	0.52366948817026
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	2/98	133/9376	1.43869878778579	PLCB1/GSK3B	0.52366948817026
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/98	50/9376	1.9134693877551	AMD1	0.665583866675145
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	3/98	227/9376	1.26440708441967	COX7B2/EGFR/NCF2	0.414448616322129
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	1/98	53/9376	1.80515979976896	PLCB1	0.604106721453217
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	2/98	140/9376	1.3667638483965	PRKAG2/PLCB1	0.449345160591429
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	2/98	142/9376	1.34751365334866	UBA6/BIRC6	0.428837347556838
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	1/98	56/9376	1.70845481049563	GSK3B	0.546474250164233
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	1/98	56/9376	1.70845481049563	NAIP	0.546474250164233
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	4/98	333/9376	1.14923086351658	EGFR/NOTCH2/UBR4/GSK3B	0.284967934988416
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/98	59/9376	1.6215842269111	DPYD	0.492220203314299
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1/98	59/9376	1.6215842269111	IRS2	0.492220203314299
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	2/98	150/9376	1.2756462585034	EGFR/GSK3B	0.349753845566559
Organismal Systems	Nervous system	hsa04730	Long-term depression	1/98	60/9376	1.59455782312925	PLCB1	0.474817235475456
Organismal Systems	Digestive system	hsa04978	Mineral absorption	1/98	61/9376	1.56841753094681	TRPV6	0.457733231772508
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	1/98	62/9376	1.54312047399605	NOTCH2	0.440956140376003
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	2/98	155/9376	1.23449637919684	OLR1/NCF2	0.302541162480923
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	1/98	63/9376	1.51862649821833	KMT2C	0.424474560799468
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/98	63/9376	1.51862649821833	RAD23B	0.424474560799468
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	1/98	63/9376	1.51862649821833	GSK3B	0.424474560799468
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	1/98	65/9376	1.47189952904239	PLCB1	0.392355324719077
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	1/98	65/9376	1.47189952904239	PLCB1	0.392355324719077
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	3/98	254/9376	1.13000160694199	PDGFD/EGFR/PLCB1	0.215869873456356
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	1/98	67/9376	1.42796222966799	PLCB1	0.361295722352834
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	1/98	69/9376	1.38657202011239	VAV3	0.331223847156438
Organismal Systems	Endocrine system	hsa04924	Renin secretion	1/98	69/9376	1.38657202011239	PLCB1	0.331223847156438
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	2/98	166/9376	1.15269240226211	IRS2/PLCB1	0.203992005971202
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	1/98	71/9376	1.34751365334866	EGFR	0.302074697808201
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	4/98	362/9376	1.0571654075995	PDGFD/EGFR/PRLR/GSK3B	0.11399880656176
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	2/98	168/9376	1.13896987366375	EGFR/PRLR	0.186794523891214
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	2/98	170/9376	1.12557022809124	EGFR/GSK3B	0.169803700492428
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	1/98	73/9376	1.31059547106514	EGFR	0.273789337147968
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	4/98	370/9376	1.03430777716492	GABRB1/GABRE/GABRA4/PRLR	0.0691988637339746
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	1/98	75/9376	1.2756462585034	SESN3	0.246314173791327
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	1/98	75/9376	1.2756462585034	PLCB1	0.246314173791327
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	1/98	76/9376	1.25886143931257	OLR1	0.232864977030067
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	1/98	76/9376	1.25886143931257	PLCB1	0.232864977030067
Human Diseases	Cancer: specific types	hsa05214	Glioma	1/98	76/9376	1.25886143931257	EGFR	0.232864977030067
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	3/98	275/9376	1.04371057513915	COX7B2/NCF2/GSK3B	0.0756100982877488
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	1/98	77/9376	1.24251258945136	EGFR	0.219600345748276
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	1/98	78/9376	1.22658294086866	PLCB1	0.206514824064673
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	1/98	78/9376	1.22658294086866	ARPC5	0.206514824064673
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	1/98	78/9376	1.22658294086866	NCF2	0.206514824064673
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1/98	82/9376	1.16674962667994	DPYD	0.155862613558026
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	1/98	82/9376	1.16674962667994	KLRD1	0.155862613558026
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	4/98	388/9376	0.986324426677888	COX7B2/IRS2/PLCB1/GSK3B	-0.0282749187241768
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	1/98	83/9376	1.15269240226211	ABCD3	0.143598531067489
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	1/98	86/9376	1.1124822021832	PLCB1	0.107695280309484
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	1/98	87/9376	1.09969505043397	COX7B2	0.0960108322340412
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	2/98	195/9376	0.981266352694924	NCF2/PLCB1	-0.0271685301704457
Organismal Systems	Digestive system	hsa04976	Bile secretion	1/98	90/9376	1.06303854875283	ABCG2	0.0617567756865487
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	1/98	90/9376	1.06303854875283	EGFR	0.0617567756865487
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	1/98	93/9376	1.02874698266403	NOTCH2	0.0286326179262028
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	1/98	97/9376	0.986324426677888	PLCB1	-0.0139140100937226
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	1/98	98/9376	0.976259891711787	PLCB1	-0.0242795169100728
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	1/98	99/9376	0.966398680684395	PLCB1	-0.0345415355845974
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	1/98	99/9376	0.966398680684395	PRKAG2	-0.0345415355845974
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	1/98	101/9376	0.94726207314609	PLCB1	-0.0547643923505804
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	1/98	102/9376	0.93797519007603	PLCB1	-0.0647296820971341
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	1/98	103/9376	0.928868634832574	PABPN1	-0.0746003934961861
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	1/98	103/9376	0.928868634832574	PLCB1	-0.0746003934961861
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	1/98	103/9376	0.928868634832574	PLCB1	-0.0746003934961861
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	1/98	105/9376	0.911175898931001	TAB3	-0.0940662155458014
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	1/98	110/9376	0.869758812615955	EGFR	-0.141211489354017
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	1/98	110/9376	0.869758812615955	THSD4	-0.141211489354017
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	1/98	110/9376	0.869758812615955	CPEB4	-0.141211489354017
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	1/98	115/9376	0.831943212067436	PLCB1	-0.186357780175082
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	2/98	235/9376	0.814242292661746	COX7B2/PRKAG2	-0.296384447627726
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	2/98	238/9376	0.803978734350883	EGFR/NRP1	-0.314802072298836
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	1/98	119/9376	0.803978734350883	TAB3	-0.221163283853611
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	1/98	120/9376	0.797278911564626	GSK3B	-0.229693852178477
Genetic Information Processing	Transcription	hsa03040	Spliceosome	2/98	243/9376	0.787435962039137	HNRNPA3/HNRNPU	-0.345030662018898
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	1/98	125/9376	0.765387755102041	PLCB1	-0.271383121239296
Organismal Systems	Immune system	hsa04611	Platelet activation	1/98	126/9376	0.759313249109167	PLCB1	-0.279536216301378
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	3/98	368/9376	0.779946761313221	COX7B2/NUP153/HNRNPA3	-0.442597521218502
Human Diseases	Infectious disease: viral	hsa05162	Measles	1/98	136/9376	0.703481392557023	GSK3B	-0.357978473996739
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	1/98	138/9376	0.693286010056196	COX7B2	-0.373040205614403
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	1/98	138/9376	0.693286010056196	CPEB4	-0.373040205614403
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	1/98	142/9376	0.673756826674332	NCF2	-0.40258923860795
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	1/98	142/9376	0.673756826674332	NCF2	-0.40258923860795
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	1/98	144/9376	0.664399092970522	GSK3B	-0.41708826030566
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	1/98	144/9376	0.664399092970522	PLCB1	-0.41708826030566
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	1/98	154/9376	0.621256294725682	COASY	-0.487040096744011
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	1/98	154/9376	0.621256294725682	PLCB1	-0.487040096744011
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	1/98	157/9376	0.60938515533602	GULP1	-0.507257123443024
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	1/98	157/9376	0.60938515533602	GSK3B	-0.507257123443024
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	1/98	158/9376	0.605528287264273	GSK3B	-0.513922402209939
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	1/98	158/9376	0.605528287264273	GSK3B	-0.513922402209939
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	2/98	298/9376	0.64210382139433	PRLR/RELL1	-0.645270180955322
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	2/98	308/9376	0.621256294725682	COX7B2/PLCB1	-0.694602781468439
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	1/98	173/9376	0.553025834611301	PABPN1	-0.609834871657779
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	1/98	183/9376	0.522805843648935	XRN1	-0.669982599421107
Cellular Processes	Cell motility	hsa04814	Motor proteins	1/98	194/9376	0.493162213338944	KIF21A	-0.73311600080003
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	1/98	196/9376	0.488129945855893	GSK3B	-0.744282675032136
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	3/98	480/9376	0.597959183673469	COX7B2/PLCB1/GSK3B	-0.92931911390579
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	1/98	205/9376	0.466699850671976	UBR4	-0.79343577991152
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	1/98	214/9376	0.447072286858669	TRIM5	-0.840914018658781
NA	NA	hsa04382	Cornified envelope formation	1/98	217/9376	0.440891563998871	CLDN1	-0.856393523848803
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	1/98	224/9376	0.427113702623907	NRP1	-0.891878983221545
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	1/98	226/9376	0.423333935344049	VAV3	-0.901860901951421
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	1/98	268/9376	0.356990557416997	COX7B2	-1.09760159275003