category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	11/198	105/9376	4.96084656084656	ATG9B/RRAS2/MAPK8/ULK1/USP15/SMURF1/BNIP3L/TAX1BP1/GABARAPL1/ARIH1/ATF4	5.99464658415915
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	14/198	170/9376	3.89970291146762	NEDD4L/TIAM1/TJP1/PPP2R2A/PRKAG2/MAPK8/AMOTL1/ARPC5/DLG2/ARHGAP17/PARD6B/CLDN1/RAP1A/NEDD4	5.60385238459347
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	9/198	93/9376	4.58260019550342	NECTIN3/TJP1/EGFR/WASL/SMURF1/EP300/CTNNA1/CTNNA2/RAP1A	5.09964389883666
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	14/198	250/9376	2.65179797979798	CYTH3/NEDD4L/PIP5K1B/EGFR/DNAJC6/ARAP2/WASL/ARPC5/RAB11FIP1/SMURF1/PARD6B/GRK7/AGAP3/NEDD4	3.88804165719422
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	10/198	142/9376	3.33475601081235	UBE2H/NEDD4L/UBE2E2/HERC4/UBA6/UBE3A/UBR5/UBE2R2/SMURF1/NEDD4	4.11751268599756
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	7/198	73/9376	4.5407499654075	XPO1/NUP153/MLLT1/TRIM5/SUPT5H/EP300/CCNT2	4.46056000282631
NA	NA	hsa04519	Cadherin signaling	19/198	404/9376	2.22702270227023	VAV3/TJP1/RRAS2/EGFR/NCKAP1/PCDH1/MAPK8/GABRE/YWHAZ/SHOC2/AMOTL1/ARPC5/EP300/CTNNA1/FLT4/DAAM1/PPP1CB/CTNNA2/WWC1	3.70290742739235
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	11/198	169/9376	3.08218277449047	ATG9B/RRAS2/STX7/WDFY3/IRS2/CTSL/MAPK8/ULK1/RHEB/TAX1BP1/GABARAPL1	4.01187447966883
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	9/198	122/9376	3.49329359165425	CSHL1/CSH2/CSH1/PLCB1/IRS2/ADCY7/MAPK8/EP300/ATF4	4.07129709376128
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	10/198	149/9376	3.17808962104264	CYTH3/PLCB1/PIP5K1B/RRAS2/EGFR/AGPAT5/DGKI/ADCY7/GAB1/RHEB	3.93625138172047
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	7/198	89/9376	3.7244353648848	SLC38A1/ADCY7/GABRE/GNGT1/GABARAPL1/GNB1/GLS	3.792957672855
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	11/198	200/9376	2.60444444444444	CYTH3/NAIP/TJP1/NCKAP1/WASL/TAB3/MAPK8/ARPC5/MYO6/CLDN1/TAB2	3.36866004753103
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	12/198	232/9376	2.44932079414838	VAV3/TIAM1/PIP5K1B/RRAS2/DOCK1/EGFR/ITGB4/DIAPH2/NCKAP1/WASL/ARPC5/PPP1CB	3.28310379935707
NA	NA	hsa04517	IgSF CAM signaling	14/198	299/9376	2.21722239113543	NECTIN3/GRIP1/NRCAM/VAV3/MTSS1/TJP1/CABLES1/RASA1/CD96/WASL/MAPK8/ARPC5/PARD6B/RAP1A	3.14180022029713
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	12/198	238/9376	2.38757321110262	RALGAPA2/TIAM1/RRAS2/EGFR/RASA1/GAB1/MAPK8/SHOC2/FLT4/GNGT1/GNB1/RAP1A	3.18465957368542
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	6/198	78/9376	3.64257964257964	DOCK1/GAB1/WASL/ARPC5/CTNNA1/CTNNA2	3.4421106108962
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	8/198	130/9376	2.91406371406371	PLCB1/EGFR/ADCY7/MAPK8/GNGT1/COL3A1/GNB1/ATF4	3.2277160993827
NA	NA	hsa04081	Hormone signaling	11/198	219/9376	2.37848807711821	CSHL1/CSH2/CSH1/PLCB1/PRLR/IRS2/ADCY7/ACVR1/THRB/GNGT1/GNB1	3.03174500781066
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	8/198	133/9376	2.84833295359611	DEPP1/EGFR/PRKAG2/IRS2/MAPK8/CDKN1A/EP300/GABARAPL1	3.15314365360713
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	12/198	253/9376	2.24601748712421	CYTH3/PLCB1/NAIP/DOCK1/EGFR/TNIP1/WASL/TAB3/MAPK8/ARPC5/CAST/TAB2	2.95093584122494
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	15/198	362/9376	1.96216306713544	CSHL1/CSH2/CSH1/PPP2R2A/EGFR/PRLR/ITGB4/YWHAZ/CDKN1A/RHEB/FLT4/GNGT1/CSF3R/GNB1/ATF4	2.74213225591501
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	5/198	62/9376	3.81883349625285	TLE3/CTBP2/EP300/NOTCH2/SPEN	3.2707048744027
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	7/198	115/9376	2.88238910847607	PLCB1/EGFR/JUND/ADCY7/CDKN1A/AKAP13/ATF4	2.98313966073655
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	10/198	203/9376	2.33268647061751	VAV3/PIP5K1B/DOCK1/EGFR/ARHGAP5/ITGB4/MAPK8/FLT4/PPP1CB/RAP1A	2.81945078178036
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	6/198	90/9376	3.15690235690236	PRKAG2/IRS2/ADCY7/ULK1/RHEB/ATF4	3.01982382181195
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	5/198	65/9376	3.64257964257964	PLCB1/PBX1/ADCY7/NCEH1/ATF4	3.14000837685182
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	5/198	67/9376	3.53384592190562	PLCB1/EP300/PPP1CB/RAP1A/ATF4	3.05710457952331
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	11/198	248/9376	2.10035842293907	CYTH3/NAIP/NCKAP1/WASL/TAB3/MAPK8/KPNA1/ARPC5/AHNAK/MYO6/TAB2	2.57938638755781
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	8/198	155/9376	2.44405343760182	PLCB1/PBX1/EGFR/ADCY7/CDKN1A/NCEH1/RAP1A/ATF4	2.66259007890176
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	8/198	157/9376	2.41291899890626	PPP2R2A/YWHAZ/DLG2/CTNNA1/PPP1CB/CTNNA2/PARD6B/WWC1	2.6222215989544
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	6/198	99/9376	2.8699112335476	PIP5K1B/EGFR/GPCPD1/DGKI/MAPK8/RHEB	2.74712876442726
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	7/198	133/9376	2.4922913343966	PLCB1/PPP2R2A/MAPK8/PPP1CB/GNGT1/GNB1/ATF4	2.54575829599895
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/198	29/9376	4.89864158829676	GNGT1/GRK7/GNB1	3.08830650012639
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	8/198	168/9376	2.25493025493025	CSHL1/CSH2/CSH1/EGFR/PRLR/CDKN1A/EP300/CSF3R	2.41065900231832
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	7/198	138/9376	2.40199092373005	VAV3/PIP5K1B/DOCK1/WASL/MAPK8/ARPC5/TAB2	2.43691270948868
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	5/198	83/9376	2.85262261165876	AEBP2/LCOR/ASXL3/EP300/MBD5	2.48995927902303
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	7/198	144/9376	2.30190796857464	PLCB1/ATXN2/RORA/PUM2/MAPK8/ULK1/SEM1	2.31237273489898
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	3/198	34/9376	4.17825311942959	NR1D2/RORA/PRKAG2	2.72679328362771
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	4/198	59/9376	3.21040917651087	EGFR/CDKN1A/CTNNA1/CTNNA2	2.50152495435082
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	6/198	116/9376	2.44932079414838	VAV3/ARHGAP5/CTNNA1/CTNNA2/CLDN1/RAP1A	2.30691839060912
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	6/198	116/9376	2.44932079414838	PLCB1/SLC38A1/ADCY7/GNGT1/GNB1/GLS	2.30691839060912
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	5/198	93/9376	2.5458889975019	PLCB1/EGFR/ADCY7/MAPK8/ATF4	2.20049209071221
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	5/198	94/9376	2.51880507199656	JUND/TAB3/MAPK8/USP25/TAB2	2.17364887229312
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	9/198	226/9376	1.88576025744167	VAV3/TIAM1/GLI3/RRAS2/ADCY7/MAPK8/EP300/PPP1CB/RAP1A	1.97972136291377
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	9/198	227/9376	1.87745294353224	PLCB1/EGFR/ADCY7/CDKN1A/RHEB/GNGT1/GNB1/AKAP13/ATF4	1.96559553373137
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	8/198	193/9376	1.96284084366986	PLCB1/VAV3/TIAM1/ADCY7/GNGT1/GRK7/GNB1/RAP1A	1.98511226997514
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	5/198	98/9376	2.41599670171099	VAV3/PIP5K1B/DOCK1/ARPC5/MARCKS	2.06962805164704
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	5/198	99/9376	2.391592694623	EGFR/ADCY7/MAPK8/CDKN1A/NOTCH2	2.04442021160165
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	9/198	233/9376	1.82910651580179	FBN2/SNTB1/FBN3/PLEC/ITGB4/DIAPH2/DAAM1/COL3A1/PDLIM5	1.88229693681575
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	4/198	70/9376	2.70591630591631	GAB1/CDKN1A/EP300/RAP1A	2.10411476041596
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	8/198	201/9376	1.88471782501633	PBX1/JMJD1C/MLLT1/CDKN1A/BMP2K/KDM6A/CCNT2/PROM1	1.86227569955988
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	5/198	103/9376	2.29871530842405	PABPN1/PPP2R2A/PABPC1/SMG7/PPP1CB	1.94655486384553
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	8/198	204/9376	1.85700138641315	VAV3/TIAM1/RRAS2/EGFR/GAB1/CTSL/CDKN1A/PPP1CB	1.81764385202596
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/198	21/9376	4.50986050986051	COASY/DPYD	2.36494919268436
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	6/198	140/9376	2.02943722943723	PLCB1/RRAS2/PRKAG2/ADCY7/GNGT1/GNB1	1.80246206302773
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	8/198	212/9376	1.78692586239756	PLCB1/VAV3/TIAM1/EGFR/ADCY7/FLT4/PARD6B/RAP1A	1.70217189516893
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	5/198	109/9376	2.17218052080437	SLC27A6/PRKAG2/IRS2/MAPK8/PPP1CB	1.80793317560997
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	4/198	78/9376	2.42838642838643	CNOT6L/PAN3/XRN1/PABPC1	1.86055474067358
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	7/198	178/9376	1.8622176824424	TBL1XR1/PLCB1/TLE3/CTBP2/MAPK8/EP300/DAAM1	1.70578554702067
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	8/198	216/9376	1.75383464272353	PLCB1/VAV3/NFE2L2/POU2F1/MAPK8/RAP1A/ATF4/TAB2	1.64626383261396
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	6/198	149/9376	1.90685377262558	PLCB1/ADCY7/MAPK8/GABRE/GNGT1/GNB1	1.6388693931736
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	5/198	115/9376	2.05884936319719	PLCB1/ADCY7/GNGT1/GNB1/ATF4	1.67802475900234
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	7/198	187/9376	1.77259223248528	NEK7/PLCB1/NAIP/TAB3/MAPK8/GABARAPL1/TAB2	1.56740497774919
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	10/198	300/9376	1.57845117845118	RRAS2/EGFR/JUND/DUSP16/RASA1/MAPK8/FLT4/RAP1A/ATF4/TAB2	1.4956304571483
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	3/198	54/9376	2.6307519640853	SMS/AMD1/DNMT3A	1.76512086042871
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	6/198	154/9376	1.84494293585203	PLCB1/EGFR/PRKAG2/ADCY7/CDKN1A/PPP1CB	1.5528138196688
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	4/198	86/9376	2.2024900164435	EGFR/GAB1/MAPK8/CDKN1A	1.64538318473755
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	4/198	86/9376	2.2024900164435	SNTB1/ITGB4/CTNNA1/CTNNA2	1.64538318473755
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	5/198	122/9376	1.94071866203014	PPP2R2A/PRKAG2/IRS2/ULK1/RHEB	1.53609874408301
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	5/198	122/9376	1.94071866203014	PLCB1/THRB/RHEB/EP300/NOTCH2	1.53609874408301
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	4/198	89/9376	2.12824877993417	PLCB1/TJP1/EGFR/ADCY7	1.57074743702777
Human Diseases	Substance dependence	hsa05032	Morphine addiction	4/198	91/9376	2.08147408147408	ADCY7/GABRE/GNGT1/GNB1	1.52261486146789
Organismal Systems	Immune system	hsa04611	Platelet activation	5/198	126/9376	1.87910854577521	PLCB1/ADCY7/PPP1CB/COL3A1/RAP1A	1.45915394845011
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	6/198	163/9376	1.74307492098903	MAPK8/YWHAZ/CDKN1A/EP300/ATF4/TAB2	1.40562695641312
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	3/198	62/9376	2.29130009775171	PRKAG2/IRS2/ADCY7	1.49830116948999
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	2/198	32/9376	2.95959595959596	ATG9B/GABARAPL1	1.63086989615207
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	4/198	97/9376	1.95272310736228	PLCB1/ADCY7/GNGT1/GNB1	1.38530749895971
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	6/198	170/9376	1.67130124777184	EGFR/NFE2L2/TXNRD1/GAB1/CDKN1A/ARID2	1.29733052418214
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	4/198	99/9376	1.9132741556984	PLCB1/ADCY7/MAPK8/PPP1CB	1.34171165877603
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	10/198	333/9376	1.42202808869476	PPP2R2A/EGFR/ITGB4/UBE3A/CDKN1A/RHEB/EP300/DLG2/PARD6B/NOTCH2	1.15173195083927
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	5/198	138/9376	1.71570780266432	PRKAG2/IRS2/MAPK8/RHEB/PPP1CB	1.24402905259373
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	5/198	142/9376	1.66737800540617	NFE2L2/CTSL/MAPK8/ACVR1/ACVR2B	1.17696983791448
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	2/198	37/9376	2.55965055965056	PLCB1/HBB	1.39611819268314
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	3/198	70/9376	2.02943722943723	PRKAG2/IRS2/MAPK8	1.26973056173299
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	4/198	106/9376	1.78692586239756	EGFR/CDKN1A/EP300/ATF4	1.19671598163709
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	3/198	71/9376	2.00085360648741	TJP1/EGFR/MAPK8	1.24332810470074
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	4/198	107/9376	1.77022562069291	PLCB1/PRKAG2/EP300/ATF4	1.17689472221914
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	2/198	38/9376	2.4922913343966	NEDD4L/NR3C2	1.35382549142136
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	4/198	108/9376	1.75383464272353	XPO1/NUP153/KPNA1/THOC7	1.15728190742837
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	3/198	73/9376	1.94603569946036	EGFR/FHIT/CDKN1A	1.19179525340277
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	4/198	110/9376	1.72194674012856	ACVR1/SMURF1/EP300/ACVR2B	1.11866373947226
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	5/198	150/9376	1.57845117845118	EGFR/GAB1/CDKN1A/CTNNA1/CTNNA2	1.04893800552467
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	3/198	75/9376	1.89414141414141	PLCB1/ADCY7/ATF4	1.14186885311413
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	2/198	41/9376	2.30992855383099	EGFR/CDKN1A	1.23460088192597
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	3/198	77/9376	1.84494293585203	EGFR/MAPK8/CDKN1A	1.09344973777251
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/198	42/9376	2.25493025493025	ACAT2/TPH2	1.19716646624912
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	4/198	115/9376	1.64707949055775	PLCB1/TPH2/GNGT1/GNB1	1.02546730813523
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	5/198	154/9376	1.53745244654336	PLCB1/PPP2R2A/ADCY7/PPP1CB/ATF4	0.987715916656278
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	5/198	156/9376	1.51774151774152	PPP2R2A/EGFR/YWHAZ/CDKN1A/CLDN1	0.957754139668953
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	5/198	157/9376	1.50807437431641	GULP1/PBX1/DOCK1/DUSP16/DNMT3A	0.942929919718724
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	5/198	157/9376	1.50807437431641	RRAS2/ZFP36L1/CDKN1A/RHEB/PPP1CB	0.942929919718724
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	4/198	119/9376	1.59171547406841	TAB3/MAPK8/ATF4/TAB2	0.954103485119908
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	9/198	323/9376	1.31944835350408	EGFR/IRS2/CDKN1A/DNMT3A/FOXP1/MARCKS/EP300/NOTCH2/GLS	0.858123630877388
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	4/198	120/9376	1.57845117845118	GAB1/MAPK8/RAP1A/ATF4	0.936677022804099
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	3/198	82/9376	1.73244641537324	KLRD1/CTSL/CD74	0.978420754889426
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	2/198	47/9376	2.01504405759725	IRS2/MAPK8	1.02461446355265
NA	NA	hsa03272	Virion - Hepatitis viruses	2/198	48/9376	1.97306397306397	EGFR/CLDN1	0.992686121301452
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	3/198	86/9376	1.65186751233263	PLCB1/ADCY7/ATF4	0.891959042322073
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	5/198	166/9376	1.42631130582938	PLCB1/IRS2/ADCY7/PPP1CB/ATF4	0.813945424015832
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	3/198	87/9376	1.63288052943225	EGFR/MAPK8/CDKN1A	0.871045991170402
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	2/198	50/9376	1.89414141414141	SMS/AMD1	0.931081535031579
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	4/198	128/9376	1.47979797979798	ADK/ADCY7/FHIT/GDA	0.802756250806939
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	8/198	298/9376	1.27123584841706	CSHL1/CSH2/CSH1/PRLR/ACVR1/CSF3R/RELL1/ACVR2B	0.698882776737227
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	2/198	52/9376	1.82128982128982	HSD17B1/ADCY7	0.872250418410957
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	2/198	52/9376	1.82128982128982	VAPA/NCEH1	0.872250418410957
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/198	17/9376	2.78550207961973	TXNRD1	1.08221688114292
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/198	17/9376	2.78550207961973	PCDH1	1.08221688114292
NA	NA	hsa04382	Cornified envelope formation	6/198	217/9376	1.30931434157241	TJP1/PPP2R2A/PLEC/ITGB4/COL17A1/CLDN1	0.677095770386693
Organismal Systems	Digestive system	hsa04970	Salivary secretion	3/198	93/9376	1.52753339850114	TRPV6/PLCB1/ADCY7	0.750916186649983
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	5/198	180/9376	1.31537598204265	POU2F1/RHEB/PPP1CB/CD74/TAB2	0.627494023487471
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	2/198	56/9376	1.69119769119769	MGAT4A/MGAT5	0.761960648542219
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	2/198	56/9376	1.69119769119769	GLI3/SMURF1	0.761960648542219
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	4/198	138/9376	1.37256624213146	SPDYA/ADCY7/YWHAZ/PPP1CB	0.647587224146255
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	6/198	224/9376	1.26839826839827	XPO1/ADCY7/MAPK8/CDKN1A/EP300/ATF4	0.597158914201059
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	4/198	139/9376	1.36269166484994	PLCB1/EGFR/ADCY7/ATF4	0.63273769776348
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	3/198	98/9376	1.44959802102659	PLCB1/PIP5K1B/DGKI	0.657134776625737
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	3/198	98/9376	1.44959802102659	PLCB1/ADCY7/ATF4	0.657134776625737
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/198	20/9376	2.36767676767677	LSS	0.8992854517993
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	3/198	99/9376	1.4349556167738	SNTB1/ITGB4/PRKAG2	0.639003105950423
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	5/198	184/9376	1.28678085199824	SEMA6A/RASA1/SEMA3B/EPHB6/PARD6B	0.57702982475608
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	4/198	142/9376	1.33390240432494	JUND/FOSL2/MAPK8/TAB2	0.588861268297866
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2/198	59/9376	1.60520458825544	IRS2/ADCY7	0.684911371205186
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	3/198	101/9376	1.40654065406541	PLCB1/ADCY7/EP300	0.603325825722332
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	3/198	101/9376	1.40654065406541	PLCB1/MAPK8/COL3A1	0.603325825722332
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/198	21/9376	2.25493025493025	CHST11	0.845573858258669
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	4/198	144/9376	1.31537598204265	PRKAG2/TAB3/MAPK8/TAB2	0.560152360781564
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	3/198	102/9376	1.39275103980986	PLCB1/ADCY7/RAP1A	0.58577130101661
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	3/198	103/9376	1.37922918505443	PLCB1/PPP2R2A/MAPK8	0.568400487690906
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	3/198	104/9376	1.36596736596737	GPCPD1/AGPAT5/DGKI	0.551209285622657
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	4/198	148/9376	1.27982527982528	EGFR/CDKN1A/FLT4/NOTCH2	0.503974100220854
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	3/198	105/9376	1.35295815295815	SNTB1/ITGB4/ADCY7	0.534193726890922
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	2/198	63/9376	1.50328683662017	KMT2C/ACAT2	0.588688092772732
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/198	63/9376	1.50328683662017	GLI3/CDKN1A	0.588688092772732
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/198	23/9376	2.05884936319719	GLS	0.746735566985226
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/198	23/9376	2.05884936319719	ACAT2	0.746735566985226
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/198	23/9376	2.05884936319719	LNPEP	0.746735566985226
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/198	23/9376	2.05884936319719	GLS	0.746735566985226
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	5/198	196/9376	1.20799835085549	MAPK8/CDKN1A/EP300/GNGT1/GNB1	0.432225906029639
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	2/198	65/9376	1.45703185703186	AGPAT5/DGKI	0.543061725158553
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	3/198	110/9376	1.29146005509642	EGFR/CDKN1A/EP300	0.451620288614214
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	3/198	110/9376	1.29146005509642	SPDYA/ADCY7/MAPK8	0.451620288614214
NA	NA	hsa04082	Neuroactive ligand signaling	5/198	199/9376	1.18978732044059	PLCB1/ADCY7/GABRE/GNGT1/GNB1	0.397454641576568
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	4/198	157/9376	1.20645949945313	PRKAG2/IRS2/MAPK8/ATF4	0.383166026640165
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/198	26/9376	1.82128982128982	SLC19A3	0.615916041768971
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	4/198	158/9376	1.19882367983634	YWHAZ/CDKN1A/EP300/STAG1	0.370188144170906
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	2/198	69/9376	1.37256624213146	VAV3/MAPK8	0.456212726733982
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	2/198	69/9376	1.37256624213146	PPP1CB/ATF4	0.456212726733982
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	5/198	205/9376	1.1549642769155	MAPK8/CDKN1A/SEM1/NEDD4/TAB2	0.329491628328523
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	5/198	205/9376	1.1549642769155	UBE3A/YWHAZ/CDKN1A/EP300/ATF4	0.329491628328523
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/198	27/9376	1.75383464272353	ACAT2	0.576128819795744
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	2/198	71/9376	1.33390240432494	PRLR/MAPK8	0.414796170821983
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	2/198	71/9376	1.33390240432494	EGFR/GLS	0.414796170821983
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/198	28/9376	1.69119769119769	TPH2	0.537980023133659
Human Diseases	Cancer: specific types	hsa05218	Melanoma	2/198	73/9376	1.29735713297357	EGFR/CDKN1A	0.374604066046885
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/198	29/9376	1.63288052943225	WWC1	0.501335916262812
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	5/198	214/9376	1.10639101293307	TRIM5/MAPK8/GNGT1/GNB1/TAB2	0.231238899251176
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	3/198	122/9376	1.16443119721808	VAV3/PPP2R2A/MAPK8	0.26849956924387
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	2/198	76/9376	1.2461456671983	PLCB1/ADCY7	0.316447540056279
Human Diseases	Cancer: specific types	hsa05214	Glioma	2/198	76/9376	1.2461456671983	EGFR/CDKN1A	0.316447540056279
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/198	31/9376	1.52753339850114	TKT	0.432101089191122
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/198	31/9376	1.52753339850114	DPYD	0.432101089191122
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/198	31/9376	1.52753339850114	ACAT2	0.432101089191122
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/198	31/9376	1.52753339850114	SPCS2	0.432101089191122
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	5/198	217/9376	1.09109528464367	EGFR/ADCY7/KPNA1/NOTCH2/ATF4	0.199409544416367
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	2/198	77/9376	1.22996195723468	CTBP2/CDKN1A	0.297596241315823
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	2/198	78/9376	1.21419321419321	PLCB1/PIP5K1B	0.278998870450961
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	3/198	125/9376	1.13648484848485	PLCB1/PPP2R2A/MAPK8	0.225626088602769
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/198	32/9376	1.47979797979798	MAPK8	0.399310928181563
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	4/198	173/9376	1.09487943013955	XPO1/PABPN1/KPNA1/EP300	0.185001229542562
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/198	33/9376	1.4349556167738	STX7	0.367623229239177
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	2/198	80/9376	1.18383838383838	EGFR/GAB1	0.242536628422004
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	2/198	85/9376	1.11420083184789	ADK/GDA	0.15534300672019
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	3/198	134/9376	1.06015377657169	PLCB1/ADCY7/PPP1CB	0.10300932044531
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/198	37/9376	1.27982527982528	GLS	0.250485059951028
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	1/198	37/9376	1.27982527982528	CDKN1A	0.250485059951028
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	3/198	137/9376	1.03693873036939	CTSL/MAPK8/ATF4	0.0639696494460075
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/198	38/9376	1.2461456671983	NMNAT2	0.223306449065938
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	5/198	238/9376	0.99482217129276	EGFR/MAPK8/RPS12/RPS29/TAB2	-0.0118837850366924
Organismal Systems	Digestive system	hsa04976	Bile secretion	2/198	90/9376	1.05230078563412	ADCY7/NCEH1	0.0732249922449979
Human Diseases	Substance dependence	hsa05034	Alcoholism	4/198	191/9376	0.991697075466709	PPP1CB/GNGT1/GNB1/ATF4	-0.0170275592643813
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	8/198	388/9376	0.976361553681141	BACE2/PLCB1/IRS2/RTN4/MAPK8/ULK1/SEM1/ATF4	-0.0698469531096262
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	1/198	41/9376	1.1549642769155	SEM1	0.146053028913191
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/198	41/9376	1.1549642769155	GABRE	0.146053028913191
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	2/198	93/9376	1.01835559900076	MAPK8/NOTCH2	0.0261282346188691
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	2/198	93/9376	1.01835559900076	FHIT/CDKN1A	0.0261282346188691
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	1/198	42/9376	1.12746512746513	PCBP2	0.121597973766201
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/198	43/9376	1.10124500822175	ACAT2	0.0977330430918042
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/198	43/9376	1.10124500822175	ACAT2	0.0977330430918042
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	1/198	44/9376	1.07621671258035	MGAT4A	0.0744274933255255
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/198	44/9376	1.07621671258035	MNAT1	0.0744274933255255
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/198	45/9376	1.05230078563412	KLRD1	0.051652884765835
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	1/198	46/9376	1.02942468159859	SEM1	0.0293828604637101
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	4/198	205/9376	0.923971421532397	PLCB1/MAPK8/PPP1CB/COL3A1	-0.161655193167221
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	1/198	47/9376	1.00752202879862	ACAT2	0.00759295071444907
NA	NA	hsa04518	Integrin signaling	3/198	154/9376	0.922471467926013	EGFR/ITGB4/FLT4	-0.142479889368772
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/198	48/9376	0.986531986531986	ACAT2	-0.0137396002948298
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/198	48/9376	0.986531986531986	PLCB1	-0.0137396002948298
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	2/198	103/9376	0.919486123369618	COL17A1/COL3A1	-0.120676700386407
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	2/198	103/9376	0.919486123369618	PLCB1/COL3A1	-0.120676700386407
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/198	49/9376	0.966398680684395	ATF4	-0.0346359886026518
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	2/198	105/9376	0.901972101972102	TAB3/TAB2	-0.148362880267607
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	2/198	105/9376	0.901972101972102	RRAS2/MAPK8	-0.148362880267607
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	1/198	50/9376	0.947070707070707	HBB	-0.0551159878396461
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	3/198	160/9376	0.887878787878788	NECTIN3/NRCAM/CLDN1	-0.2100974344327
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	1/198	51/9376	0.928500693206576	TJP1	-0.0751980719640693
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	2/198	109/9376	0.86887220832175	MAPK8/TAB2	-0.202247248279556
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	2/198	109/9376	0.86887220832175	RORA/MAPK8	-0.202247248279556
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	1/198	53/9376	0.89346293119878	PLCB1	-0.114236540611127
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	2/198	112/9376	0.845598845598846	MAPK8/TAB2	-0.241437367899435
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	1/198	56/9376	0.845598845598846	NAIP	-0.170208328588763
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/198	57/9376	0.830763778132199	ACAT2	-0.188230631789648
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	2/198	116/9376	0.816440264716127	ACAT2/TKT	-0.292176397945447
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	2/198	117/9376	0.809462142795476	EPC2/ARID2	-0.304604540191111
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	3/198	174/9376	0.816440264716127	NFE2L2/MAPK8/ATF4	-0.358967507107136
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/198	59/9376	0.802602294127718	DPYD	-0.223395420367632
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	1/198	59/9376	0.802602294127718	SMS	-0.223395420367632
Organismal Systems	Nervous system	hsa04730	Long-term depression	1/198	60/9376	0.789225589225589	PLCB1	-0.240559756674485
Organismal Systems	Digestive system	hsa04978	Mineral absorption	1/198	61/9376	0.776287464812055	TRPV6	-0.257458961990555
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	4/198	235/9376	0.8060176230389	PRKAG2/ADCY7/RHEB/ATP5MG	-0.442327112135968
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/198	63/9376	0.751643418310085	MNAT1	-0.290499476172336
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	3/198	181/9376	0.784865226854177	MAPK8/EP300/CD74	-0.429257844273935
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	1/198	65/9376	0.728515928515929	PLCB1	-0.322587158739202
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/198	66/9376	0.717477808386899	HSD17B1	-0.338293692544644
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	1/198	66/9376	0.717477808386899	RORA	-0.338293692544644
Organismal Systems	Endocrine system	hsa04924	Renin secretion	1/198	69/9376	0.68628312106573	PLCB1	-0.384150834338281
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	2/198	133/9376	0.712083238399028	VAV3/KLRD1	-0.491168492041937
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	1/198	70/9376	0.676479076479077	SNTB1	-0.399037835632937
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	5/198	308/9376	0.768726223271678	PLCB1/MAPK8/ULK1/EP300/SEM1	-0.6061640859752
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	1/198	72/9376	0.657687991021324	MAPK8	-0.428250362561944
Human Diseases	Infectious disease: viral	hsa05162	Measles	2/198	136/9376	0.696375519904932	MAPK8/TAB2	-0.523859060082645
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	4/198	254/9376	0.745724966197407	PLCB1/EGFR/ADCY7/FLT4	-0.603420071159504
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	6/198	368/9376	0.772068511198946	NUP153/ATXN2/ULK1/SEM1/HNRNPA3/ATF4	-0.655176413702411
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	6/198	370/9376	0.767895167895168	CSHL1/CSH2/CSH1/PRLR/GABRE/THRB	-0.669057247225365
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	1/198	75/9376	0.631380471380471	TKT	-0.470747861270278
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	1/198	75/9376	0.631380471380471	CDKN1A	-0.470747861270278
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	1/198	75/9376	0.631380471380471	CDKN1A	-0.470747861270278
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	1/198	76/9376	0.623072833599149	SLC27A6	-0.484581654211451
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	1/198	78/9376	0.607096607096607	MAPK8	-0.511779064660348
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	1/198	78/9376	0.607096607096607	TAB2	-0.511779064660348
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	2/198	144/9376	0.657687991021324	ACVR1/ACVR2B	-0.607994555296715
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	4/198	268/9376	0.706769184381125	NFE2L2/MAPK8/SEM1/ATF4	-0.715335372708218
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1/198	82/9376	0.577482138457748	DPYD	-0.564410223557136
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	2/198	154/9376	0.614980978617342	COASY/NMNAT2	-0.707577792381298
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/198	86/9376	0.550622504110876	PLCB1	-0.614889242508874
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	2/198	155/9376	0.611013359400456	STX7/CTSL	-0.717225514732823
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	2/198	158/9376	0.599411839918169	ULK1/RHEB	-0.745851739991928
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	1/198	89/9376	0.532062194983543	ITGB4	-0.651462798799465
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	1/198	90/9376	0.526150392817059	EGFR	-0.663424715146741
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	1/198	91/9376	0.52036852036852	VAV3	-0.675276487365569
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	3/198	227/9376	0.62581764784408	EGFR/NFE2L2/MAPK8	-0.838211513928042
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	1/198	95/9376	0.498458266879319	CTSL	-0.72163186047958
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	1/198	100/9376	0.473535353535354	CSF3R	-0.777379437872143
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	3/198	250/9376	0.568242424242424	OSBPL3/CTSL/CD164	-1.01628132549233
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	2/198	183/9376	0.51752497654137	XPO1/XRN1	-0.968090497795268
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	3/198	275/9376	0.516584022038568	MAPK8/SEM1/ATF4	-1.19505253393246
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	6/198	480/9376	0.591919191919192	PLCB1/ATXN2/MAPK8/ULK1/SEM1/ATF4	-1.3480736153968
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	1/198	138/9376	0.343141560532865	ATP5MG	-1.14173826119617
Genetic Information Processing	Translation	hsa03010	Ribosome	2/198	222/9376	0.426608426608427	RPS12/RPS29	-1.26989129473938
Genetic Information Processing	Transcription	hsa03040	Spliceosome	2/198	243/9376	0.38974103171634	HNRNPA3/THOC7	-1.41564638769116
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	1/198	168/9376	0.281866281866282	MAPK8	-1.37949938308212
Cellular Processes	Cell motility	hsa04814	Motor proteins	1/198	194/9376	0.244090388420285	MYO6	-1.56259451291258
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	1/198	195/9376	0.242838642838643	PLCB1	-1.56929633196582
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/198	449/9376	0.105464443994511	GNB1	-2.85306862147458