category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	23/333	232/9376	2.79134306720514	DIAPH2/EGFR/ARPC5/NCKAP1/RRAS2/PIP5K1B/VAV3/PDGFD/AKT3/SCIN/PPP1R12B/ARHGEF12/PIP5K1A/PPP1CB/WASL/IQGAP2/RDX/TIAM1/PIKFYVE/PTK2/DOCK1/PAK2/ITGB1	5.30159002623282
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	12/333	93/9376	3.63305240724596	NECTIN3/EGFR/HEG1/RAP1B/TJP1/CTNNA1/WASL/ARHGAP29/CTNNA2/INSR/PDCD10/EP300	4.89675405688376
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	12/333	104/9376	3.24878724878725	AGPAT5/DGKI/GDPD5/CEPT1/SGMS1/GNPAT/PISD/CHKA/CDS1/ETNK1/SGMS2/LPIN2	4.4251685559056
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	18/333	203/9376	2.4966049793636	EGFR/PIP5K1B/VAV3/PDGFD/RAP1B/FLT4/AKT3/GSK3B/PPP1R12B/PIP5K1A/PPP1CB/PTK2/DOCK1/PAK2/ELK1/BCL2/ARHGAP5/ITGB1	4.13667115095117
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	14/333	138/9376	2.85642163903033	ARPC5/PIP5K1B/VAV3/AKT3/GSK3B/ARHGEF12/PIP5K1A/WASL/RPS6KA6/ELMO1/PTK2/MAP2K4/DOCK1/ITGB1	4.21578715069983
NA	NA	hsa04517	IgSF CAM signaling	23/333	299/9376	2.16585816585817	RASA1/NECTIN3/NRCAM/GRIP1/ANK3/ARPC5/NLGN4Y/VAV3/RAP1B/MTSS1/TJP1/AKT3/GSK3B/WASL/RDX/CABLES1/TRIO/RAPGEF2/PTK2/EPB41L2/PARD6B/PAK2/ITGB1	3.93153037064094
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	17/333	204/9376	2.34634634634635	EGFR/ANK3/RRAS2/VAV3/FRS2/AKT3/PPP1R12B/ARHGEF12/PPP1CB/RDX/TIAM1/PTK2/GAB1/CD44/ELK1/GPC1/ITGB1	3.73070875503495
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	10/333	90/9376	3.12846179512846	PRKAG2/ADCY7/AKT3/SESN3/CREB3L2/CREB5/PPARG/SESN1/INSR/ULK1	3.89335732065362
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	9/333	78/9376	3.24878724878725	PLCB1/PIP5K1B/PIP5K1A/PIK3C2B/PIKFYVE/INPPL1/PPIP5K2/INPP5F/MINPP1	3.8269464919473
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	9/333	78/9376	3.24878724878725	ARPC5/CTNNA1/WASL/ELMO1/PTK2/CTNNA2/DOCK1/GAB1/ITGB1	3.8269464919473
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	10/333	98/9376	2.87307715879144	PLCB1/PIP5K1B/DGKI/PIP5K1A/PIK3C2B/PIKFYVE/INPPL1/PPIP5K2/INPP5F/CDS1	3.5767864464275
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	13/333	149/9376	2.45657738275188	PLCB1/CYTH3/AGPAT5/EGFR/RRAS2/PIP5K1B/PDGFD/DGKI/ADCY7/AKT3/PIP5K1A/INSR/GAB1	3.43912471769321
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	11/333	116/9376	2.66998032515274	VAV3/RAP1B/CLDN1/CTNNA1/PTK2/CTNNA2/NCF2/CD99L2/ARHGAP5/ITGB1/CLDN16	3.47285255699828
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	14/333	170/9376	2.31874227168345	PRKAG2/ARPC5/ARHGAP17/CLDN1/TJP1/NEDD4/RDX/TIAM1/RAPGEF2/DLG1/PARD6B/ITGB1/CLDN16/YBX3	3.32966386103799
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	11/333	122/9376	2.53866981735834	CSHL1/PLCB1/CSH2/ADCY7/AKT3/GSK3B/CREB3L2/CREB5/PTK2/MAP2K4/EP300	3.28255560828525
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	8/333	73/9376	3.0856061540993	TRIM5/MLLT1/FURIN/NUP153/PDCD6IP/EP300/CCNT2/MAP1S	3.43268307541348
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	12/333	142/9376	2.37939347798503	UBE2H/UBR5/NEDD4/BIRC6/UBA6/PIAS1/HERC1/FBXW11/UBE3A/CUL3/UBE2E3/UBE2E2	3.17825614136608
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	13/333	169/9376	2.16585816585817	DAPK1/WDFY3/ATG9B/RRAS2/GABARAPL1/AKT3/STX7/BIRC6/TAX1BP1/BCL2/ATG10/EPG5/ULK1	2.93482012956136
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	9/333	98/9376	2.5857694429123	ARPC5/PIP5K1B/VAV3/AKT3/SCIN/PIP5K1A/INPPL1/DOCK1/MARCKS	3.02815002785432
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	17/333	253/9376	1.89191563104607	NAIP/PLCB1/CYTH3/EGFR/ARPC5/TAB3/CAST/AKT3/GSK3B/WASL/ELMO1/PTK2/DOCK1/FBXW11/CD44/BCL2/ITGB1	2.75973059187643
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	15/333	216/9376	1.95528862195529	PLCB1/POU2F1/VAV3/RAP1B/AKT3/GSK3B/TRAF3/PTK2/PPARG/MAP2K4/NFE2L2/OLR1/NCF2/PPP3CB/BCL2	2.7256195357102
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	19/333	300/9376	1.78322322322322	RASA1/EGFR/RRAS2/PDGFD/MAP4K3/RAP1B/FLT4/AKT3/RPS6KA6/RAPGEF2/MAP2K4/INSR/PPP3CB/MAP2K5/PAK2/STK3/ELK1/ARTN/JUND	2.64575989759843
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	8/333	86/9376	2.61917731685174	EGFR/AKT3/GSK3B/PTK2/MAP2K4/GAB1/PAK2/ELK1	2.89459141229113
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	8/333	89/9376	2.5308904410028	GABRB1/SLC38A1/GABRE/GLS/GABRA4/GABARAPL1/ADCY7/GNGT1	2.78453628413297
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	6/333	56/9376	3.01673101673102	GSK3B/GLI3/KIF3A/FBXW11/BCL2/CUL3	2.90459459269667
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	13/333	184/9376	1.98929364146755	RASA1/SEMA6A/GSK3B/ARHGEF12/PTK2/PPP3CB/RYK/PARD6B/PAK2/FES/EPHB6/SEMA3B/ITGB1	2.60064223269867
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	6/333	59/9376	2.86333791418537	EGFR/CTNNA1/AKT3/GSK3B/CTNNA2/ELK1	2.75506004471077
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	14/333	212/9376	1.85936880276503	PLCB1/EGFR/VAV3/PDGFD/RAP1B/ADCY7/FLT4/AKT3/TIAM1/RAPGEF2/INSR/PARD6B/ITGB1/RAP1GAP	2.42860264345932
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	15/333	238/9376	1.7745476569006	RASA1/RASAL2/RALGAPA2/EGFR/RRAS2/PDGFD/RAP1B/FLT4/AKT3/TIAM1/GNGT1/INSR/GAB1/PAK2/ELK1	2.32253643465001
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	8/333	99/9376	2.27524494191161	EGFR/PIP5K1B/PDGFD/DGKI/AKT3/SLC44A1/PIP5K1A/CHKA	2.44770411610918
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	13/333	200/9376	1.83015015015015	NAIP/CYTH3/ARPC5/NCKAP1/TAB3/CLDN1/TJP1/ARHGEF12/WASL/SEC24B/PAK2/ITGB1/CLDN16	2.27717514918103
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	11/333	160/9376	1.93573573573574	NECTIN3/NRCAM/NLGN4Y/CLDN1/NRXN3/HLA-DMA/NEGR1/CD99L2/ITGB1/CLDN16/VSIR	2.29083317255203
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	7/333	83/9376	2.37461557943486	LCOR/ASXL3/PHC3/RYBP/SUZ12/EP300/MBD5	2.41375857084236
NA	NA	hsa04519	Cadherin signaling	22/333	404/9376	1.53325602830553	GABRB1/GABRE/EGFR/ARPC5/NCKAP1/RRAS2/VAV3/GABRA4/FLT4/TJP1/CTNNA1/GSK3B/PCDH11Y/PPP1CB/PTK2/CTNNA2/DAAM1/RYK/WWC1/STK3/EP300/LHFPL2	2.10248697185607
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	6/333	67/9376	2.52144681995428	PLCB1/RAP1B/PPP1CB/RPS6KA6/PPP3CB/EP300	2.39824833999174
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	4/333	34/9376	3.31248895954778	PRKAG2/RORA/FBXW11/PER3	2.59209362854059
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	15/333	250/9376	1.68936936936937	CYTH3/EGFR/ARPC5/PIP5K1B/ARAP2/SPART/NEDD4/PIP5K1A/WASL/DNAJC6/PDCD6IP/PSD4/PARD6B/VPS37A/ARFGAP1	2.11998722661985
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	8/333	106/9376	2.12499291744575	EGFR/PDGFD/AKT3/GSK3B/CREB3L2/CREB5/EP300/BCL2	2.23518947296503
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	8/333	107/9376	2.10513317055373	PLCB1/PRKAG2/AKT3/CREB3L2/CREB5/PPP3CB/PPP4R3B/EP300	2.20618309136324
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	5/333	52/9376	2.70732270732271	ADCY7/CYP19A1/INSR/CYP1B1/HSD17B1	2.36901409895223
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	8/333	109/9376	2.06650687384632	PRKAG2/AKT3/GSK3B/CREB3L2/PPP1CB/CREB5/RPS6KA6/INSR	2.14911084580004
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3/333	23/9376	3.67254210732472	GLS/ATP1A1/GLUD1	2.46243342055502
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	5/333	56/9376	2.51394251394251	MGAT5/STT3B/FUT8/MAN2A1/MAN1A2	2.18045401353469
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	6/333	75/9376	2.25249249249249	PLCB1/ADCY7/CREB3L2/CREB5/ATP1A1/CANX	2.08974084070858
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	8/333	115/9376	1.95868912390652	PLCB1/EGFR/ADCY7/CREB3L2/CREB5/AKAP13/BCL2/JUND	1.98494861279962
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	12/333	201/9376	1.68096454663619	MLLT1/CDK14/FUT8/AFF1/PBX1/JMJD1C/FUS/KDM6A/PTK2/PPARG/BMP2K/CCNT2	1.87271195703192
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	13/333	226/9376	1.61960190278774	RRAS2/VAV3/RAP1B/ADCY7/AKT3/CREB3L2/PPP1CB/CREB5/TIAM1/CNGA1/GLI3/ATP1A1/EP300	1.80928884198608
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	13/333	227/9376	1.6124670926433	PLCB1/EGFR/ADCY7/AKT3/GSK3B/ARHGEF12/CREB3L2/CREB5/GNGT1/AKAP13/PTK2/PPP3CB/ELK1	1.79250495025617
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	8/333	120/9376	1.87707707707708	RAP1B/FRS2/AKT3/GSK3B/RPS6KA6/GAB1/MAP2K5/BCL2	1.8555309392477
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	6/333	80/9376	2.11171171171171	EGFR/PDGFD/AKT3/GSK3B/GAB1/BCL2	1.91619898777662
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	9/333	142/9376	1.78454510848877	AKT3/PTK2/MAP2K4/GSTA4/NFE2L2/NCF2/MAP2K5/BCL2/GPC1	1.80766789826755
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	8/333	122/9376	1.84630532171516	PRKAG2/AKT3/CREB3L2/CREB5/PPARG/INSR/TBC1D1/ULK1	1.80548435328849
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	8/333	122/9376	1.84630532171516	PLCB1/NOTCH2/NCOA2/AKT3/GSK3B/ATP1A1/EP300/MED13	1.80548435328849
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	4/333	44/9376	2.55965055965056	STT3B/FUT8/MAN2A1/MAN1A2	1.98983821885416
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	10/333	166/9376	1.69615398531061	PLCB1/ADCY7/AKT3/CREB3L2/PPP1CB/CREB5/CNGA1/ATP1A1/INSR/PPP3CB	1.7365249685053
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	13/333	233/9376	1.57094433489283	FBN2/DIAPH2/ANK3/PDLIM5/FBN1/FBN3/FMNL2/ATP1A1/DAAM1/SGCE/PLEC/ITGB1/NEB	1.69347526717722
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	3/333	28/9376	3.01673101673102	A4GALT/ST3GAL6/B3GNT2	2.05078027213406
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	10/333	168/9376	1.67596167596168	CSHL1/CSH2/EGFR/CSF3R/AKT3/PIAS1/PRLR/EP300/BCL2/PIM1	1.69646751977895
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	7/333	105/9376	1.87707707707708	ATG9B/RRAS2/GABARAPL1/USP15/AMFR/TAX1BP1/ULK1	1.73428556421757
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	5/333	65/9376	2.16585816585817	PLCB1/ADCY7/PBX1/CREB3L2/CREB5	1.80990476512626
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	10/333	170/9376	1.65624447977389	EGFR/AKT3/GSK3B/TXNRD1/GSTA4/NFE2L2/GAB1/ARID2/ELK1/ARID1B	1.6569375041868
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	11/333	193/9376	1.60475501408144	PLCB1/VAV3/RAP1B/ADCY7/AKT3/GSK3B/TIAM1/GNGT1/ELMO1/PTK2/PREX1	1.62898591687158
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	12/333	217/9376	1.55702246024827	EGFR/NOTCH2/ADCY7/AKT3/CREB3L2/CREB5/RPS6KA6/GSTA4/CYP1B1/BCL2/KPNA4/KPNA1	1.59305230051057
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/333	14/9376	4.02230802230802	FUT8/B3GNT2	2.17155039723713
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	7/333	108/9376	1.82493604715827	TNPO1/NUP153/THOC7/KPNA4/XPO6/EEF1A1/KPNA1	1.65459091759974
NA	NA	hsa03272	Virion - Hepatitis viruses	4/333	48/9376	2.34634634634635	EGFR/CLDN1/PDCD6IP/CLDN16	1.79446352712219
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	8/333	130/9376	1.73268653268653	PLCB1/EGFR/ADCY7/AKT3/CREB3L2/CREB5/GNGT1/MAP2K4	1.61422634187238
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	6/333	89/9376	1.8981678307521	PLCB1/EGFR/PDGFD/ADCY7/TJP1/MAP2K5	1.63367726846081
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	9/333	154/9376	1.64548964548965	PLCB1/ADCY7/KCNE1/AKT3/CREB3L2/PPP1CB/CREB5/ATP1A1/BCL2	1.54984608650119
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	9/333	154/9376	1.64548964548965	PLCB1/EGFR/PRKAG2/ADCY7/PPP1R12B/PPP1CB/PPP3CB/MAP2K5/ELK1	1.54984608650119
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	8/333	133/9376	1.6936033778139	PLCB1/AKT3/GSK3B/CREB3L2/PPP1CB/CREB5/GNGT1/PPP3CB	1.54590226311249
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	10/333	178/9376	1.58180652562675	TBL1XR1/PLCB1/FRZB/GSK3B/DAAM1/PPP3CB/RYK/FBXW11/CTBP2/EP300	1.50381141157118
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	12/333	224/9376	1.50836550836551	ADCY7/AKT3/CREB3L2/CREB5/MAP2K4/DLG1/PPP3CB/GPS2/HLA-DMA/EP300/ELK1/CANX	1.4777248266961
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	5/333	70/9376	2.01115401115401	RAP1B/AKT3/GAB1/PAK2/EP300	1.6294322003053
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	3/333	32/9376	2.63963963963964	ATG9B/GABARAPL1/ATG10	1.78282400481366
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	13/333	248/9376	1.47592754044367	NAIP/CYTH3/ARPC5/NCKAP1/TAB3/AKT3/WASL/PIK3C2B/ELMO1/MAP2K4/BCL2/KPNA4/KPNA1	1.45757312141923
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	9/333	157/9376	1.6140471681873	GULP1/PBX1/DNMT3A/ELMO1/PTK2/PPARG/DOCK1/STAB1/TMEM30A	1.48888495384988
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	9/333	157/9376	1.6140471681873	CTNNA1/GSK3B/PPP1CB/CTNNA2/DLG1/FBXW11/WWC1/PARD6B/STK3	1.48888495384988
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	3/333	33/9376	2.55965055965056	STX7/SEC22B/VTI1A	1.7222357119814
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	6/333	93/9376	1.81652620362298	AKT3/TRAF3/PTK2/FHIT/BCL2/ITGB1	1.51851440143752
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	7/333	115/9376	1.7138529834182	PLCB1/ADCY7/AKT3/CREB3L2/CREB5/GNGT1/BCL2	1.47801978122472
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	8/333	139/9376	1.62049819603776	PLCB1/EGFR/NCOA2/ADCY7/AKT3/CREB3L2/CREB5/BCL2	1.4142752494721
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	6/333	99/9376	1.70643370643371	EGFR/NOTCH2/ADCY7/AKT3/PTK2/BCL2	1.3559282881013
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	8/333	144/9376	1.56423089756423	PRKAG2/TAB3/AKT3/GSK3B/TRAF3/TRA2A/MAP2K4/LPIN2	1.30930764081389
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/333	37/9376	2.28293158022888	PLCB1/HBB/THOP1	1.50039517747259
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	5/333	78/9376	1.8048818048818	NCF2/HLA-DMA/ELK1/EEF1A1/ITGB1	1.36973366479456
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	17/333	362/9376	1.3222504272228	CSHL1/CSH2/EGFR/PDGFD/FLT4/CSF3R/AKT3/GSK3B/CREB3L2/CREB5/GNGT1/PTK2/PRLR/INSR/BCL2/ARTN/ITGB1	1.1998874190239
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	3/333	38/9376	2.22285443338075	ATP1A1/INSR/NR3C2	1.44940953975981
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	4/333	59/9376	1.90889194279025	ADCY7/AKT3/INSR/MGLL	1.34385280172636
Organismal Systems	Immune system	hsa04611	Platelet activation	7/333	126/9376	1.56423089756423	PLCB1/RAP1B/ADCY7/AKT3/ARHGEF12/PPP1CB/ITGB1	1.22355292723816
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	9/333	174/9376	1.45635290462877	STT3B/BCAP29/MAN1A2/SEC24B/RAD23B/NFE2L2/AMFR/BCL2/CANX	1.16596581715379
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/333	21/9376	2.68153868153868	DPYD/COASY	1.48028760657933
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	3/333	41/9376	2.06020654801143	GABRB1/GABRE/GABRA4	1.30549958746589
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	4/333	62/9376	1.81652620362298	PRKAG2/ADCY7/AKT3/INSR	1.23779676686993
NA	NA	hsa04518	Integrin signaling	8/333	154/9376	1.46265746265746	EGFR/PDGFD/FBN1/FLT4/AKT3/GSK3B/PTK2/ITGB1	1.11085880757438
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	8/333	155/9376	1.45322096289838	STX7/PIKFYVE/SEC22B/OLR1/NCF2/HLA-DMA/CANX/ITGB1	1.09178800037371
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	8/333	155/9376	1.45322096289838	PLCB1/EGFR/RAP1B/ADCY7/PBX1/GSK3B/CREB3L2/CREB5	1.09178800037371
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	5/333	86/9376	1.63698582303233	PLCB1/ADCY7/CREB3L2/CREB5/ATP1A1	1.13873488339476
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	7/333	133/9376	1.48190295558717	EGFR/PRKAG2/GABARAPL1/DEPP1/AKT3/INSR/EP300	1.07406465059441
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/333	23/9376	2.44836140488314	GLS/GLUD1	1.33449479379632
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/333	23/9376	2.44836140488314	THOP1/LNPEP	1.33449479379632
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	4/333	65/9376	1.73268653268653	AGPAT5/DGKI/MGLL/LPIN2	1.13743925778234
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	3/333	45/9376	1.87707707707708	ABCD3/ABCA5/ABCG2	1.13170025129279
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	7/333	138/9376	1.42821081951517	PRKAG2/AKT3/GSK3B/PPP1CB/INSR/INPPL1/ELK1	0.972433003768272
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	5/333	91/9376	1.54704154704155	VAV3/AKT3/GSK3B/INPPL1/PPP3CB	1.00623992102911
Human Diseases	Substance dependence	hsa05032	Morphine addiction	5/333	91/9376	1.54704154704155	GABRB1/GABRE/GABRA4/ADCY7/GNGT1	1.00623992102911
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	8/333	163/9376	1.38189723465797	AKT3/TRAF3/CREB3L2/CREB5/MAP2K4/EP300/ELK1/BCL2	0.943824550247036
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	4/333	69/9376	1.63224093658876	CREB3L2/PPP1CB/CREB5/PPP3CB	1.01147182598498
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	7/333	140/9376	1.40780780780781	PLCB1/PRKAG2/RRAS2/ADCY7/AKT3/GNGT1/NRF1	0.932887087135832
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	6/333	116/9376	1.45635290462877	PLCB1/SLC38A1/GLS/ADCY7/GNGT1/PPP3CB	0.949020972201366
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	5/333	93/9376	1.51377183635248	PLCB1/EGFR/ADCY7/MAP2K4/ELK1	0.955474458863147
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	5/333	94/9376	1.4976678806466	TAB3/USP25/GSK3B/TRAF3/JUND	0.930538286585151
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	3/333	48/9376	1.75975975975976	PLCB1/AKT3/ATP1A1	1.01263778221988
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	6/333	119/9376	1.41963812552048	TAB3/AKT3/TRAF3/CREB3L2/CREB5/MAP2K4	0.884025467878119
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	7/333	144/9376	1.3687020353687	PLCB1/ATXN2/AKT3/PUM2/RORA/SEM1/ULK1	0.85557950508536
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	6/333	122/9376	1.38472899128637	VAV3/AKT3/GSK3B/DLG1/PPP3CB/PAK2	0.820770183290648
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	5/333	98/9376	1.43653857939572	PLCB1/ADCY7/CREB3L2/CREB5/ATP1A1	0.833604353561598
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/333	29/9376	1.94180387283836	WWC1/STK3	0.974708692477213
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/333	29/9376	1.94180387283836	GNGT1/CNGA1	0.974708692477213
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	4/333	75/9376	1.50166166166166	AKT3/GSTA4/TOP2B/BCL2	0.837005306519541
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	7/333	149/9376	1.3227724368664	GABRB1/PLCB1/GABRE/GABRA4/ADCY7/GNGT1/MGLL	0.762097969501692
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	7/333	150/9376	1.31395395395395	EGFR/CTNNA1/AKT3/GSK3B/CTNNA2/GAB1/BCL2	0.743800302900613
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	5/333	101/9376	1.39386911664139	PLCB1/ADCY7/GSK3B/CREB3L2/EP300	0.763672490243941
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	4/333	78/9376	1.44390544390544	PAN3/CNOT6L/XRN1/CNOT2	0.755430458006374
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	3/333	54/9376	1.56423089756423	AMD1/DNMT3A/APIP	0.797904078161022
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/333	31/9376	1.81652620362298	IMMP2L/IMMP1L	0.873801548666579
NA	NA	hsa04981	Folate transport and metabolism	2/333	31/9376	1.81652620362298	ABCG2/SLCO2B1	0.873801548666579
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	5/333	103/9376	1.36680369690078	PABPN1/PPP1CB/FUS/SMG7/SMG1	0.718279838174037
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	8/333	180/9376	1.25138471805138	POU2F1/AKT3/TRAF3/PPP1CB/CD74/HLA-DMA/SRPK1/BCL2	0.653472225795932
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	3/333	55/9376	1.53579033579034	SGMS1/B4GALT5/SGMS2	0.764709448347822
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/333	32/9376	1.75975975975976	BIRC6/BCL2	0.826107093805598
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	7/333	156/9376	1.26341726341726	EGFR/CLDN1/AKT3/GSK3B/TRAF3/PIAS1/CLDN16	0.636638006403013
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	3/333	56/9376	1.50836550836551	NAIP/SEC22B/EEF1A1	0.732172855210712
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	10/333	235/9376	1.19813430451728	PRKAG2/FRS2/ADCY7/CREB3L2/CREB5/RPS6KA6/COX7B2/PPARG/MGLL/ARID1B	0.590266642752996
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	7/333	158/9376	1.2474246398297	AKT3/GSK3B/RICTOR/RPS6KA6/INSR/LPIN2/ULK1	0.601872676446314
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	4/333	82/9376	1.37347103200762	KLRD1/CD74/HLA-DMA/CANX	0.651799470606972
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	6/333	134/9376	1.26072340997714	PLCB1/CALD1/ADCY7/PPP1R12B/ARHGEF12/PPP1CB	0.583312031305771
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	8/333	187/9376	1.20454143983556	NEK7/NAIP/PLCB1/TAB3/GABARAPL1/TRAF3/BCL2/GBP2	0.542150017096599
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	5/333	110/9376	1.27982527982528	EGFR/AKT3/INSR/EP300/BCL2	0.566485282099132
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	3/333	60/9376	1.40780780780781	AKT3/PTK2/PPP3CB	0.608090069594304
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	13/333	323/9376	1.13321990721372	EGFR/GLS/NOTCH2/FOXP1/DICER1/RDX/DNMT3A/CD44/CYP1B1/EP300/MARCKS/BCL2/PIM1	0.467547368882439
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	4/333	86/9376	1.30958865842587	CTNNA1/CTNNA2/SGCE/ITGB1	0.553449373762631
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	2/333	36/9376	1.56423089756423	B4GALT5/ST6GALNAC3	0.650857878787063
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	4/333	87/9376	1.29453591522557	EGFR/AKT3/GSK3B/BCL2	0.529620630405111
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	3/333	62/9376	1.36239465271723	NOTCH2/CTBP2/EP300	0.549365014220003
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/333	37/9376	1.52195438681925	GLS/GLUD1	0.610428378966676
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	2/333	37/9376	1.52195438681925	PPARG/TFG	0.610428378966676
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	3/333	63/9376	1.34076934076934	UVSSA/RAD23B/MNAT1	0.520759830399974
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/333	38/9376	1.48190295558717	NADK2/NMNAT2	0.571183880926412
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	8/333	196/9376	1.14923086351658	AKT3/GSK3B/TRAF3/GNGT1/MAP2K4/PPP3CB/EP300/PREX1	0.405150926720224
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	5/333	117/9376	1.20325453658787	MBD3/MTA1/ARID2/ARID1B/SMARCA5	0.424524369918818
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	13/333	333/9376	1.09918927936946	EGFR/NOTCH2/AKT3/GSK3B/TRAF3/CREB3L2/CREB5/PTK2/DLG1/PARD6B/EP300/UBE3A/ITGB1	0.353656851241395
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	9/333	227/9376	1.11632337182998	EGFR/AKT3/PTK2/COX7B2/MAP2K4/GSTA4/NFE2L2/NCF2/CYP1B1	0.340443139460493
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3/333	66/9376	1.27982527982528	CYP19A1/CYP1B1/HSD17B1	0.437759483749343
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/333	15/9376	1.87707707707708	ST6GALNAC3	0.652339621132838
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/333	15/9376	1.87707707707708	ALPP	0.652339621132838
Organismal Systems	Digestive system	hsa04970	Salivary secretion	4/333	93/9376	1.21101746908199	PLCB1/TRPV6/ADCY7/ATP1A1	0.392434516288773
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	2/333	41/9376	1.37347103200762	SSBP1/SEM1	0.459878576614063
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	2/333	41/9376	1.37347103200762	DAPK1/EGFR	0.459878576614063
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/333	16/9376	1.75975975975976	A4GALT	0.583646444446489
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	8/333	205/9376	1.09877682560609	AKT3/NEDD4/TRAF3/MAP2K4/HLA-DMA/CD44/BCL2/SEM1	0.274394333444733
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	3/333	69/9376	1.22418070244157	VAV3/AKT3/MAP2K4	0.358648817763381
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	4/333	97/9376	1.16107860437757	PLCB1/ADCY7/GNGT1/PER3	0.306002255366202
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	5/333	125/9376	1.12624624624625	PLCB1/AKT3/SGMS1/BCL2/SGMS2	0.272665775424563
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/333	17/9376	1.65624447977389	TXNRD1	0.519669094916922
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/333	17/9376	1.65624447977389	GLUD1	0.519669094916922
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/333	17/9376	1.65624447977389	PCDH11Y	0.519669094916922
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	7/333	181/9376	1.08891211653643	AKT3/ARHGEF12/CD74/PPP3CB/HLA-DMA/EP300/BCL2	0.231779946801272
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	3/333	71/9376	1.18969673899251	AKT3/GSK3B/PRLR	0.30788061139146
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	3/333	71/9376	1.18969673899251	EGFR/TJP1/MAP2K4	0.30788061139146
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	3/333	71/9376	1.18969673899251	EGFR/GLS/AKT3	0.30788061139146
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	2/333	44/9376	1.27982527982528	ICA1/HLA-DMA	0.357007557207337
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	2/333	44/9376	1.27982527982528	CREB3L2/CREB5	0.357007557207337
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	4/333	100/9376	1.12624624624625	CSF3R/HLA-DMA/CD44/CD59	0.243550818476361
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	2/333	45/9376	1.25138471805138	KLRD1/HLA-DMA	0.324363908287298
Human Diseases	Cancer: specific types	hsa05218	Melanoma	3/333	73/9376	1.15710230778724	EGFR/PDGFD/AKT3	0.258573476104145
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	3/333	73/9376	1.15710230778724	EGFR/AKT3/FHIT	0.258573476104145
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	4/333	101/9376	1.11509529331312	PLCB1/AKT3/BCL2/PIM1	0.223158164847459
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	6/333	157/9376	1.0760314454582	PRKAG2/AKT3/GSK3B/COX7B2/PPARG/INSR	0.18435403830026
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	8/333	214/9376	1.05256658527687	TRIM5/AKT3/GNGT1/PTK2/PPP3CB/FBXW11/PAK2/BCL2	0.149270160116879
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	4/333	102/9376	1.10416298651593	PLCB1/RAP1B/ADCY7/ATP1A1	0.20296981362762
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/333	19/9376	1.48190295558717	BCKDHB	0.403477726647337
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	3/333	75/9376	1.12624624624625	SESN3/SESN1/BCL2	0.210637539425023
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	3/333	76/9376	1.11142721669037	PLCB1/ADCY7/ATP1A1	0.187157869993063
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/333	20/9376	1.40780780780781	LSS	0.350329667773397
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/333	20/9376	1.40780780780781	CYB5R4	0.350329667773397
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	4/333	105/9376	1.07261547261547	RRAS2/AKT3/ARHGEF12/PPP3CB	0.143585973442085
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	2/333	49/9376	1.14923086351658	CREB3L2/CREB5	0.200972758322259
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	5/333	138/9376	1.02015058536798	ADCY7/PPP1CB/RPS6KA6/PPP3CB/FBXW11	0.045760390359255
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/333	22/9376	1.27982527982528	FTCD	0.25214542574513
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/333	23/9376	1.22418070244157	SSBP1	0.206556167037616
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	2/333	53/9376	1.06249645872287	PLCB1/ATP1A1	0.0875521855062535
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	4/333	112/9376	1.00557700557701	AKT3/HLA-DMA/BCL2/ITGB1	0.0113936351030821
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	3/333	83/9376	1.01769239118637	ABCD3/FAR2/GNPAT	0.0310669844745589
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	5/333	142/9376	0.991413949160428	AKT3/PPARG/NCF2/PPP3CB/JUND	-0.0197830925305034
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	6/333	173/9376	0.976514086340676	PABPN1/AKT3/TRAF3/HLA-DMA/EP300/KPNA1	-0.0598297640394118
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	7/333	205/9376	0.961429722405332	SCIN/TRAF3/CREB3L2/CREB5/DLG1/EP300/UBE3A	-0.107145229120567
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	7/333	205/9376	0.961429722405332	PLCB1/AKT3/GSK3B/PPP1CB/COX7B2/INSR/NCF2	-0.107145229120567
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	5/333	148/9376	0.951221491762032	EGFR/NOTCH2/FLT4/AKT3/GSK3B	-0.11477758132244
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	3/333	88/9376	0.95986895986896	TFPI/CD59/F13A1	-0.0725791935526161
Organismal Systems	Digestive system	hsa04976	Bile secretion	3/333	90/9376	0.938538538538538	ADCY7/ABCG2/ATP1A1	-0.112424583549835
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	3/333	90/9376	0.938538538538538	EGFR/AKT3/PPP3CB	-0.112424583549835
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/333	28/9376	1.00557700557701	ALPP	0.00567116433476766
Genetic Information Processing	Transcription	hsa03040	Spliceosome	8/333	243/9376	0.926951643001026	HNRNPC/TRA2A/FUS/HNRNPA3/HNRNPU/SNRNP70/THOC7/SRSF10	-0.221390178155505
Organismal Systems	Digestive system	hsa04978	Mineral absorption	2/333	61/9376	0.923152660857579	TRPV6/ATP1A1	-0.115545706384076
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	5/333	154/9376	0.914160914160914	COASY/NADK2/NMNAT2/PDXK/ALPP	-0.206103029206037
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	3/333	93/9376	0.908263101811489	NOTCH2/PPP3CB/HLA-DMA	-0.170605426285601
NA	NA	hsa04382	Cornified envelope formation	7/333	217/9376	0.908263101811489	CLDN1/TJP1/FURIN/COL17A1/PLEC/CLDN16/DST	-0.262362269262492
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	5/333	157/9376	0.896692871215164	RRAS2/AKT3/PPP1CB/PPP3CB/FBXW11	-0.250489600216278
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	2/333	63/9376	0.89384622717956	KMT2C/KMT2B	-0.162222988152293
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/333	63/9376	0.89384622717956	GSK3B/GLI3	-0.162222988152293
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/333	30/9376	0.938538538538538	ABCG2	-0.0646996768385414
NA	NA	hsa04081	Hormone signaling	7/333	219/9376	0.899968461612297	CSHL1/PLCB1/CSH2/ADCY7/GNGT1/PRLR/INSR	-0.287431186572372
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	4/333	128/9376	0.87987987987988	ADK/GDA/ADCY7/FHIT	-0.262571945259555
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/333	31/9376	0.908263101811489	TKT	-0.0981717957749733
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/333	31/9376	0.908263101811489	DPYD	-0.0981717957749733
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	2/333	65/9376	0.866343266343266	PLCB1/AKT3	-0.207491756905499
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	2/333	66/9376	0.853216853216853	RORA/HLA-DMA	-0.229627982857785
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/333	32/9376	0.87987987987988	BCKDHB	-0.130609817202466
Human Diseases	Immune disease	hsa05310	Asthma	1/333	32/9376	0.87987987987988	HLA-DMA	-0.130609817202466
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	3/333	99/9376	0.853216853216853	PLCB1/ADCY7/PPP1CB	-0.281735453910524
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	3/333	99/9376	0.853216853216853	PRKAG2/SGCE/ITGB1	-0.281735453910524
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/333	33/9376	0.853216853216853	BCKDHB	-0.162084497545131
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	2/333	68/9376	0.828122239886946	AKT3/PIM1	-0.27295901604769
Organismal Systems	Endocrine system	hsa04924	Renin secretion	2/333	69/9376	0.816120468294381	PLCB1/PPP3CB	-0.294174190458218
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	3/333	103/9376	0.820082218140471	ATP1A1/COL19A1/COL17A1	-0.352317373926713
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	3/333	103/9376	0.820082218140471	PLCB1/AKT3/MAP2K4	-0.352317373926713
NA	NA	hsa04082	Neuroactive ligand signaling	6/333	199/9376	0.848929331341392	GABRB1/PLCB1/GABRE/GABRA4/ADCY7/GNGT1	-0.413340359959591
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	2/333	70/9376	0.804461604461605	PRKAG2/AKT3	-0.315101907891029
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/333	70/9376	0.804461604461605	GSTA4/CYP1B1	-0.315101907891029
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	2/333	70/9376	0.804461604461605	HLA-DMA/SGCE	-0.315101907891029
Human Diseases	Infectious disease: viral	hsa05162	Measles	4/333	136/9376	0.828122239886946	AKT3/GSK3B/TRAF3/BCL2	-0.387440167229197
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	3/333	105/9376	0.804461604461605	TAB3/TRAF3/BCL2	-0.386647223483077
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	3/333	105/9376	0.804461604461605	ADCY7/SGCE/ITGB1	-0.386647223483077
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/333	36/9376	0.782115448782115	SSBP1	-0.251336602512095
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/333	37/9376	0.760977193409626	PNMT	-0.279538419539241
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	3/333	109/9376	0.774940077692371	AKT3/TRAF3/MAP2K4	-0.453516739411034
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	3/333	109/9376	0.774940077692371	RORA/PPP3CB/HLA-DMA	-0.453516739411034
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	3/333	110/9376	0.767895167895168	FBN1/THSD4/EP300	-0.469878816429934
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	3/333	110/9376	0.767895167895168	ADCY7/AKT3/RPS6KA6	-0.469878816429934
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/333	39/9376	0.721952721952722	FTCD	-0.333886424590492
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/333	39/9376	0.721952721952722	HLA-DMA	-0.333886424590492
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	2/333	76/9376	0.740951477793583	PPARG/OLR1	-0.435108863714369
Human Diseases	Cancer: specific types	hsa05214	Glioma	2/333	76/9376	0.740951477793583	EGFR/AKT3	-0.435108863714369
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	2/333	77/9376	0.731328731328731	EGFR/AKT3	-0.454255248976272
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	2/333	77/9376	0.731328731328731	AKT3/CTBP2	-0.454255248976272
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	9/333	308/9376	0.822744822744823	PLCB1/CREB3L2/CREB5/COX7B2/PPARG/NRF1/EP300/SEM1/ULK1	-0.606973905881252
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/333	79/9376	0.712814079902687	GSTA4/CYP1B1	-0.491877280886088
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	3/333	115/9376	0.734508421464943	GABRB1/PLCB1/GNGT1	-0.549695545074869
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/333	42/9376	0.67038467038467	CYP1B1	-0.410818164572939
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	1/333	42/9376	0.67038467038467	PCBP2	-0.410818164572939
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	7/333	250/9376	0.788372372372372	GPR155/ABCA5/PIKFYVE/OSBPL3/OSBP/VPS13C/SUMF1	-0.650809112364324
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	2/333	82/9376	0.686735516003809	DPYD/GSTA4	-0.54672412939518
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/333	44/9376	0.63991263991264	MNAT1	-0.459407773616076
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	2/333	85/9376	0.662497791909557	ADK/GDA	-0.599799833513697
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	1/333	46/9376	0.612090351220786	SEM1	-0.506081155048427
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/333	86/9376	0.654794329212934	PLCB1/GABRA4	-0.617121645501621
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/333	47/9376	0.599067152258642	INSR	-0.528755028618814
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	4/333	158/9376	0.712814079902687	NIPBL/GSK3B/RAD21/EP300	-0.698593957681964
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	2/333	87/9376	0.647267957612785	COX7B2/ATP1A1	-0.634266169238231
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/333	48/9376	0.586586586586587	BCKDHB	-0.551013707584732
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	2/333	89/9376	0.6327226102507	CD44/ITGB1	-0.668040762883503
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/333	50/9376	0.563123123123123	AMD1	-0.594357633739607
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	1/333	50/9376	0.563123123123123	HLA-DMA	-0.594357633739607
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	1/333	50/9376	0.563123123123123	HBB	-0.594357633739607
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	1/333	51/9376	0.552081493257964	CEPT1	-0.615476058620835
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	1/333	51/9376	0.552081493257964	TJP1	-0.615476058620835
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	1/333	52/9376	0.541464541464541	VAPA	-0.636245837697223
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	3/333	133/9376	0.635101266680214	KLRD1/VAV3/PPP3CB	-0.813285799477877
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	1/333	54/9376	0.521410299188077	HLA-DMA	-0.676795042051425
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	7/333	275/9376	0.716702156702157	GSK3B/CREB3L2/CREB5/COX7B2/NCF2/PPP3CB/SEM1	-0.914990421217346
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	3/333	137/9376	0.61655816400342	AKT3/BCL2/NOL3	-0.867558531645016
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/333	59/9376	0.477222985697562	DPYD	-0.772958062750261
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	1/333	59/9376	0.477222985697562	GSTA4	-0.772958062750261
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	2/333	103/9376	0.546721478760314	PLCB1/PTK2	-0.887615979977088
Organismal Systems	Nervous system	hsa04730	Long-term depression	1/333	60/9376	0.469269269269269	PLCB1	-0.791382805348307
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	3/333	144/9376	0.586586586586587	AKT3/GSK3B/TBX3	-0.959333037828743
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	6/333	254/9376	0.665106050932823	PLCB1/EGFR/PDGFD/ADCY7/FLT4/PPP3CB	-1.03831855392312
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	9/333	368/9376	0.688601645123384	ATXN2/FUS/HNRNPA3/NUP153/COX7B2/PPP3CB/BCL2/SEM1/ULK1	-1.16943886751125
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	1/333	67/9376	0.420241136659047	MINPP1	-0.913870740250205
Human Diseases	Substance dependence	hsa05034	Alcoholism	4/333	191/9376	0.589657720547773	CREB3L2/PPP1CB/CREB5/GNGT1	-1.09944841992526
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	4/333	195/9376	0.577562177562178	PLCB1/AKT3/CLCN3/NCF2	-1.14389614604418
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	2/333	116/9376	0.485450968209589	GLUD1/TKT	-1.07004429563617
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	1/333	72/9376	0.391057724391058	TRAF3	-0.995311478739777
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/333	73/9376	0.385700769262413	GSTA4	-1.01107036361959
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	1/333	75/9376	0.375415415415415	TKT	-1.04209799476401
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	9/333	388/9376	0.653106714962385	PLCB1/AKT3/RTN4/GSK3B/COX7B2/INSR/PPP3CB/SEM1/ULK1	-1.33915767149843
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	1/333	78/9376	0.360976360976361	ITGB1	-1.08747916235818
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	1/333	79/9376	0.356407039951344	SYT1	-1.10231293748277
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	6/333	298/9376	0.566902472942741	CSHL1/CSH2/CSF3R/RELL1/PRLR/ACVRL1	-1.45797553431497
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	1/333	95/9376	0.296380591117433	HLA-DMA	-1.32267674065942
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	1/333	99/9376	0.284405617738951	HLA-DMA	-1.37351128191841
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	2/333	168/9376	0.335192335192335	GLUD1/BCL2	-1.66847419070284
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	9/333	480/9376	0.527927927927928	PLCB1/ATXN2/GSK3B/FUS/COX7B2/PPP3CB/BCL2/SEM1/ULK1	-2.03743156076417
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	3/333	238/9376	0.35490953138012	EGFR/TRAF3/F13A1	-1.93434981523338
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	6/333	370/9376	0.456586316045775	CSHL1/GABRB1/CSH2/GABRE/GABRA4/PRLR	-2.04652451163473
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	1/333	138/9376	0.204030117073595	COX7B2	-1.80758483645878
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	1/333	143/9376	0.196896196896197	HLA-DMA	-1.8570336484819
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	3/333	268/9376	0.315180852494285	COX7B2/NFE2L2/SEM1	-2.1826458311249
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	1/333	183/9376	0.153858776809596	XRN1	-2.21815177134956
Cellular Processes	Cell motility	hsa04814	Motor proteins	1/333	194/9376	0.145134825547197	KIF3A	-2.30877353426314