category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	17/373	93/9376	4.59488598691228	NECTIN3/EGFR/TJP1/CTNNA1/CTNNA2/WASL/RAP1B/HEG1/INSR/PTPRM/SMURF1/SMURF2/CREBBP/ACTN4/PDCD10/TGFBR1/CDH5	7.09134882949156
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	25/373	203/9376	3.09565630819213	PIP5K1B/EGFR/DOCK1/AKT3/VAV3/GSK3B/PIP5K1A/FLT4/BCL2/PPP1CB/PPP1R12B/MYLK/RAP1B/MAPK8/LAMC1/AKT1/PAK2/PTK2/ELK1/ARHGAP5/DIAPH1/PDGFD/PGF/ACTN4/SPP1	6.14410756408415
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	25/373	232/9376	2.70869926966811	PIP5K1B/EGFR/DIAPH2/RRAS2/IQGAP2/DOCK1/AKT3/VAV3/ARPC5/TIAM1/NCKAP1/ARHGEF12/PIP5K1A/PPP1CB/PPP1R12B/MYLK/WASL/AKT1/SCIN/PAK2/PTK2/RDX/DIAPH1/PDGFD/ACTN4	5.36398984014179
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	17/373	142/9376	3.00932673790734	UBE2H/NEDD4/UBE2E2/UBR5/UBA6/BIRC6/UBE3A/UBE2E3/UBE2R2/FBXW11/PIAS1/COP1/CUL3/SMURF1/SMURF2/KEAP1/HERC4	4.91073195556816
NA	NA	hsa04517	IgSF CAM signaling	27/373	299/9376	2.26987186959212	RASA1/NECTIN3/ANK3/NRCAM/MTSS1/GRIP1/AKT3/CABLES1/VAV3/TJP1/ARPC5/NLGN4Y/EPB41L2/GSK3B/MYLK/WASL/RAP1B/MAPK8/AKT1/PAK2/PARD6B/PTK2/SRGAP2/RDX/ACTN4/EPB41L3/NCK2	4.54224711982558
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	15/373	122/9376	3.09058146178526	CSHL1/CSH1/PLCB1/CSH2/AKT3/ADCY7/CREB3L2/GSK3B/GH2/MAPK8/AKT1/MAP2K4/PTK2/CREB5/CREBBP	4.7307357707851
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	12/373	86/9376	3.50745058918885	EGFR/AKT3/GSK3B/GAB1/MAPK8/AKT1/PAK2/MAP2K4/PTK2/CDKN1A/ELK1/NCK2	4.75466782665346
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	22/373	238/9376	2.32356320544304	RASA1/RALGAPA2/RASAL2/EGFR/RRAS2/AKT3/GNGT1/TIAM1/FLT4/GAB1/RAP1B/MAPK8/AKT1/NF1/PAK2/INSR/ELK1/RALGAPA1/PDGFD/PGF/GNB1/SHOC2	4.20972780744543
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	13/373	104/9376	3.14209115281501	AGPAT5/GDPD5/DGKI/PISD/LPIN2/SGMS2/GPCPD1/CEPT1/ETNK1/CDS1/LPGAT1/LPCAT1/CHKA	4.47109949927087
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	13/373	109/9376	2.99795853112625	PRKAG2/AKT3/CREB3L2/SLC27A6/GSK3B/PPP1CB/PRKCE/MAPK8/AKT1/INSR/RPS6KA6/CREB5/GFPT2	4.27047876252765
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	15/373	138/9376	2.73225317636088	PIP5K1B/DOCK1/AKT3/VAV3/ARPC5/ARHGEF12/ELMO1/GSK3B/PIP5K1A/WASL/MAPK8/AKT1/MAP2K4/RPS6KA6/PTK2	4.17261542922792
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	12/373	99/9376	3.04687626939638	PIP5K1B/EGFR/AKT3/DGKI/PIP5K1A/SLC44A1/MAPK8/AKT1/SLC22A5/GPCPD1/PDGFD/CHKA	4.16727191392087
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	18/373	204/9376	2.21794669610472	ANK3/EGFR/RRAS2/AKT3/VAV3/TIAM1/FRS2/TWIST1/ARHGEF12/PPP1CB/PPP1R12B/GAB1/AKT1/GPC1/PTK2/CDKN1A/RDX/ELK1	3.57979182037811
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	11/373	98/9376	2.8214696066094	PIP5K1B/DOCK1/AKT3/VAV3/ARPC5/PIP5K1A/PRKCE/MARCKS/AKT1/SCIN/INPPL1	3.68938698778698
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	23/373	300/9376	1.92714924039321	RASA1/EGFR/RRAS2/AKT3/MAP4K3/FLT4/RAP1B/MAPK8/AKT1/NF1/PAK2/DUSP16/PPP3CB/JUND/MAP2K4/INSR/RPS6KA6/STK3/MAP3K12/ELK1/PDGFD/PGF/TGFBR1	3.32207520386465
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	8/373	59/9376	3.40837006407052	EGFR/AKT3/CTNNA1/CTNNA2/GSK3B/AKT1/CDKN1A/ELK1	3.77709238434239
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	14/373	149/9376	2.36184032963276	PLCB1/CYTH3/AGPAT5/PIP5K1B/EGFR/RRAS2/AKT3/ADCY7/DGKI/PIP5K1A/GAB1/AKT1/INSR/PDGFD	3.41063696103431
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	20/373	253/9376	1.98709321917155	PLCB1/CYTH3/NAIP/EGFR/TAB3/DOCK1/CAST/AKT3/ARPC5/ELMO1/GSK3B/BCL2/PRKCE/WASL/MAPK8/AKT1/FBXW11/PTK2/DIAPH1/ACTN4	3.23963454066693
NA	NA	hsa04519	Cadherin signaling	28/373	404/9376	1.74214955007565	GABRE/EGFR/RRAS2/PCDH11Y/VAV3/TJP1/ARPC5/CTNNA1/CTNNA2/NCKAP1/GSK3B/FLT4/PPP1CB/GABRB1/DVL3/WWC1/DAAM1/MAPK8/LHFPL2/YWHAZ/PTK2/STK3/RYK/CREBBP/ACTN4/EVL/CDH5/SHOC2	3.10372981126202
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	10/373	90/9376	2.79296991361335	PRKAG2/AKT3/ADCY7/CREB3L2/SESN1/AKT1/INSR/SESN3/CREB5/ULK1	3.47877504629682
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	11/373	105/9376	2.63337163283544	ATG9B/RRAS2/GABARAPL1/USP15/TAX1BP1/MAPK8/BCL2L13/AMFR/ULK1/SMURF1/SMURF2	3.42580624602296
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	15/373	169/9376	2.23107064105208	DAPK1/ATG9B/RRAS2/WDFY3/AKT3/STX7/GABARAPL1/BCL2/BIRC6/TAX1BP1/MAPK8/AKT1/SUPT20H/ULK1/SH3GLB1	3.2871058101458
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	15/373	170/9376	2.21794669610472	EGFR/AKT3/GSK3B/TXNRD1/NFE2L2/DVL3/GAB1/AKT1/ARID2/GSTA4/CDKN1A/ELK1/KEAP1/TGFBR1/ARID1A	3.26184775033572
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	11/373	106/9376	2.60852850422378	EGFR/AKT3/CREB3L2/GSK3B/BCL2/AKT1/CDKN1A/CREB5/PDGFD/CREBBP/HSP90AA1	3.38991068521168
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	13/373	140/9376	2.33412485637687	PLCB1/PRKAG2/RRAS2/AKT3/GNGT1/ADCY7/PRKCE/MYLK/AKT1/NRF1/GNB1/SPP1/TGFBR1	3.23716592610353
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	25/373	362/9376	1.73596196288122	CSHL1/CSH1/CSH2/EGFR/CSF3R/AKT3/GNGT1/CREB3L2/GSK3B/FLT4/BCL2/GH2/LAMC1/AKT1/YWHAZ/PRLR/INSR/PTK2/CDKN1A/CREB5/PDGFD/PGF/GNB1/HSP90AA1/SPP1	2.9066805627905
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	19/373	250/9376	1.91039142091153	CYTH3/PIP5K1B/EGFR/ARAP2/ARPC5/NEDD4/SPART/PIP5K1A/WASL/DNAJC6/PARD6B/KIF5B/SMURF1/SMURF2/CHMP2B/VPS37A/SH3GLB1/TGFBR1/ARFGAP1	2.96964378316269
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	9/373	83/9376	2.72566943376724	LCOR/RYBP/ASXL3/SUZ12/PHC3/RNF2/CREBBP/TEX10/SCMH1	3.21414239536893
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	12/373	130/9376	2.32031346669416	PLCB1/EGFR/AKT3/GNGT1/ADCY7/CREB3L2/MAPK8/AKT1/MAP2K4/CREB5/GNB1/TGFBR1	3.08544787257047
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	7/373	56/9376	3.14209115281501	GSK3B/BCL2/GLI3/FBXW11/CUL3/SMURF1/SMURF2	3.27243051586061
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	15/373	184/9376	2.04918988227066	RASA1/SEMA6A/ARHGEF12/GSK3B/SEMA3B/EPHB6/PAK2/PPP3CB/PARD6B/PTK2/SRGAP2/FES/RYK/SEMA3F/NCK2	2.92552912836887
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	12/373	133/9376	2.26797556894918	PLCB1/AKT3/GNGT1/CREB3L2/GSK3B/PPP1CB/MAPK8/AKT1/PPP3CB/CREB5/KIF5B/GNB1	2.99762055943176
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	14/373	168/9376	2.09472743521001	CSHL1/CSH1/CSH2/EGFR/CSF3R/AKT3/BCL2/GH2/AKT1/PIM1/PRLR/PIAS1/CDKN1A/CREBBP	2.91423397323356
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	14/373	170/9376	2.07008358303107	PRKAG2/TJP1/ARPC5/NEDD4/ARHGAP17/TIAM1/CLDN1/PRKCE/MAPK8/DLG1/PARD6B/RDX/ACTN4/CGNL1	2.86584769197565
NA	NA	hsa04518	Integrin signaling	13/373	154/9376	2.12193168761533	EGFR/AKT3/GSK3B/FLT4/LAMC1/AKT1/FBN1/PTK2/PDGFD/PGF/ACTN4/SPP1/NCK2	2.8573316041783
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	10/373	107/9376	2.34922703014207	PLCB1/PRKAG2/AKT3/CREB3L2/AKT1/PPP3CB/CREB5/CREBBP/PPP4R3A/PPP4R3B	2.85697809099559
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	18/373	248/9376	1.82444002421517	CYTH3/NAIP/TAB3/AKT3/ARPC5/NCKAP1/ELMO1/BCL2/WASL/MAPK8/AKT1/ARL8B/MAP2K4/KPNA4/KIF5B/AHNAK/HSP90AA1/KPNA1	2.67820317844625
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	12/373	142/9376	2.12423063852283	AKT3/BCL2/NFE2L2/MAPK8/AKT1/GPC1/MAP2K4/GSTA4/PTK2/KEAP1/HSP90AA1/CDH5	2.74758466001035
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	14/373	178/9376	1.97704611862518	PLCB1/TBL1XR1/FRZB/GSK3B/DVL3/DAAM1/CTBP2/MAPK8/FBXW11/PPP3CB/RYK/CREBBP/TLE3/CHD8	2.67870440203224
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	8/373	78/9376	2.57812607410463	DOCK1/ARPC5/CTNNA1/CTNNA2/ELMO1/GAB1/WASL/PTK2	2.84866024565074
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	16/373	216/9376	1.8619799424089	PLCB1/POU2F1/AKT3/VAV3/TRAF3/GSK3B/BCL2/NFE2L2/RAP1B/MAPK8/AKT1/PPP3CB/MAP2K4/PTK2/HSP90AA1/MIB1	2.60869152951373
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	13/373	163/9376	2.00476981529301	AKT3/CREB3L2/TRAF3/BCL2/MAPK8/AKT1/YWHAZ/MAP2K4/CDKN1A/CREB5/ELK1/CREBBP/TGFBR1	2.63394241212536
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	8/373	80/9376	2.51367292225201	EGFR/AKT3/GSK3B/BCL2/GAB1/AKT1/NF1/PDGFD	2.76742211410639
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	13/373	166/9376	1.96853903549856	PLCB1/AKT3/ADCY7/CREB3L2/PPP1CB/PRKCE/MYLK/AKT1/PPP3CB/INSR/CNGA1/CREB5/ATP1B3	2.56264109882001
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	9/373	99/9376	2.28515720204728	EGFR/AKT3/ADCY7/BCL2/NOTCH2/MAPK8/AKT1/PTK2/CDKN1A	2.61647447534488
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	11/373	133/9376	2.07897760487008	PRKAG2/EGFR/DEPP1/AKT3/GABARAPL1/MAPK8/AKT1/INSR/CDKN1A/CREBBP/TGFBR1	2.55081054456391
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	9/373	101/9376	2.23990656438298	PLCB1/AKT3/BCL2/PRKCE/MAPK8/AKT1/PIM1/DIAPH1/TGFBR1	2.54999375039957
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	16/373	227/9376	1.77175183947278	PLCB1/EGFR/AKT3/GNGT1/ADCY7/CREB3L2/ARHGEF12/GSK3B/AKT1/PPP3CB/PTK2/AKAP13/CDKN1A/CREB5/ELK1/GNB1	2.39579810535116
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	7/373	70/9376	2.51367292225201	AKT3/GAB1/RAP1B/AKT1/PAK2/CDKN1A/CREBBP	2.58729510552338
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	8/373	87/9376	2.31142337678346	EGFR/AKT3/GSK3B/BCL2/MAPK8/AKT1/CDKN1A/TGFBR1	2.50129258018064
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	12/373	157/9376	1.92127866668943	CTNNA1/CTNNA2/GSK3B/PPP1CB/DVL3/WWC1/DLG1/FBXW11/YWHAZ/PARD6B/STK3/TGFBR1	2.36943807212568
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	8/373	89/9376	2.25948127842877	GABRE/SLC38A1/GNGT1/ADCY7/GABARAPL1/GABRB1/GLS/GNB1	2.42993930476294
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	7/373	73/9376	2.41037129531015	TRIM5/MLLT1/NUP153/FURIN/SERINC3/CCNT2/CREBBP	2.4622367495388
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	8/373	93/9376	2.16229928795872	AKT3/TRAF3/BCL2/LAMC1/AKT1/FHIT/PTK2/CDKN1A	2.29277638433935
NA	NA	hsa04981	Folate transport and metabolism	4/373	31/9376	3.24344893193808	SLCO2B1/ABCG2/MTR/ABCC3	2.5465594019861
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	6/373	62/9376	2.43258669895356	NOTCH2/DVL3/CTBP2/CREBBP/RBPJ/TLE3	2.30353635907546
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	15/373	226/9376	1.66836698379558	RRAS2/AKT3/VAV3/ADCY7/CREB3L2/TIAM1/GLI3/PPP1CB/RAP1B/MAPK8/AKT1/CNGA1/CREB5/ATP1B3/CREBBP	2.07016561087381
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	11/373	150/9376	1.84336014298481	EGFR/AKT3/CTNNA1/CTNNA2/GSK3B/BCL2/DVL3/GAB1/AKT1/CDKN1A/TGFBR1	2.11932912226946
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	9/373	115/9376	1.96722228697983	PLCB1/AKT3/GNGT1/ADCY7/CREB3L2/BCL2/AKT1/CREB5/GNB1	2.12418678266173
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	9/373	115/9376	1.96722228697983	PLCB1/EGFR/ADCY7/CREB3L2/BCL2/JUND/AKAP13/CDKN1A/CREB5	2.12418678266173
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	4/373	33/9376	3.04687626939638	STX7/SEC22B/VTI1A/SNAP23	2.39746245964597
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	9/373	116/9376	1.95026347416104	VAV3/CTNNA1/CTNNA2/CLDN1/RAP1B/PTK2/ARHGAP5/ACTN4/CDH5	2.09610950176504
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	14/373	212/9376	1.65997268450604	PLCB1/EGFR/AKT3/VAV3/ADCY7/TIAM1/FLT4/RAP1B/AKT1/PARD6B/INSR/PDGFD/PGF/EVL	1.9783256424045
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	13/373	193/9376	1.6931475642112	PLCB1/AKT3/GNGT1/VAV3/ADCY7/TIAM1/ELMO1/GSK3B/RAP1B/AKT1/PTK2/PREX1/GNB1	1.98042542302826
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	4/373	34/9376	2.95726226147295	PRKAG2/FBXW11/RORA/PER3	2.3270996374628
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	9/373	120/9376	1.88525469168901	AKT3/FRS2/GSK3B/BCL2/GAB1/RAP1B/MAPK8/AKT1/RPS6KA6	1.98652308467641
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	6/373	67/9376	2.25105037813613	PLCB1/PPP1CB/RAP1B/PPP3CB/RPS6KA6/CREBBP	2.09173716944829
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	10/373	139/9376	1.80839778579281	PLCB1/EGFR/AKT3/ADCY7/CREB3L2/BCL2/NCOA2/AKT1/CREB5/HSP90AA1	1.95440008411486
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	9/373	122/9376	1.85434887707116	AKT3/VAV3/GSK3B/MAPK8/AKT1/PAK2/DLG1/PPP3CB/NCK2	1.93328931083086
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	13/373	200/9376	1.63388739946381	CYTH3/NAIP/TAB3/TJP1/ARPC5/NCKAP1/ARHGEF12/CLDN1/WASL/MAPK8/PAK2/TMED10/NCK2	1.84436487745903
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	10/373	144/9376	1.74560619600834	PRKAG2/TAB3/AKT3/TRAF3/GSK3B/LPIN2/MAPK8/AKT1/TRA2A/MAP2K4	1.83522486833937
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	10/373	144/9376	1.74560619600834	PLCB1/AKT3/ATXN2/PUM2/MAPK8/AKT1/SEM1/RORA/ULK1/RBPJ	1.83522486833937
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3/373	23/9376	3.27870381163306	GLUD1/GLS/ATP1B3	2.22701303310177
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	14/373	224/9376	1.57104557640751	AKT3/ADCY7/CREB3L2/MAPK8/AKT1/DLG1/PPP3CB/MAP2K4/HLA-DMA/CDKN1A/CREB5/ELK1/CREBBP/TGFBR1	1.76069124251136
Organismal Systems	Immune system	hsa04611	Platelet activation	9/373	126/9376	1.79548065875144	PLCB1/AKT3/ADCY7/ARHGEF12/PPP1CB/MYLK/RAP1B/AKT1/SNAP23	1.82974454019381
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	6/373	73/9376	2.06603253883727	EGFR/AKT3/AKT1/FHIT/CDKN1A/KIF5B	1.86108757463903
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	8/373	110/9376	1.82812576163783	AKT3/ADCY7/CPEB4/MAPK8/AKT1/SPDYA/RPS6KA6/HSP90AA1	1.77825041498852
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	6/373	75/9376	2.01093833780161	BCL2/SESN1/COP1/CDKN1A/SESN3/RRM2B	1.78910943145228
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/373	12/9376	4.18945487042002	NPC1/CD46	2.2502087595933
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	7/373	94/9376	1.87188409103873	TAB3/USP25/TRAF3/GSK3B/MAPK8/JUND/HSP90AA1	1.72921234407856
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	5/373	59/9376	2.13023129004408	AKT3/ADCY7/AKT1/INSR/MGLL	1.77256313797378
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	6/373	77/9376	1.95870617318339	EGFR/AKT3/MAPK8/AKT1/CDKN1A/TGFBR1	1.71932980403178
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	11/373	174/9376	1.58910357153863	STT3B/BCL2/NFE2L2/MAPK8/RAD23B/AMFR/BCAP29/SEC61A1/LMAN1/HSP90AA1/EDEM1	1.5965098208911
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	10/373	154/9376	1.63225514431949	PLCB1/AKT3/ADCY7/CREB3L2/KCNE1/BCL2/PPP1CB/AKT1/CREB5/ATP1B3	1.61022513733277
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	10/373	154/9376	1.63225514431949	PLCB1/PRKAG2/EGFR/ADCY7/PPP1CB/PPP1R12B/MYLK/PPP3CB/CDKN1A/ELK1	1.61022513733277
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	6/373	78/9376	1.93359455557847	PLCB1/PIP5K1B/PIP5K1A/INPP5F/INPPL1/MINPP1	1.68522258118146
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	6/373	78/9376	1.93359455557847	PAN3/CNOT6L/XRN1/CNOT7/CNOT2/EXOSC6	1.68522258118146
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	10/373	155/9376	1.62172446596904	PLCB1/EGFR/PBX1/ADCY7/CREB3L2/GSK3B/DVL3/RAP1B/CDKN1A/CREB5	1.58862438680968
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	12/373	196/9376	1.53898342178695	AKT3/GNGT1/TRAF3/GSK3B/MAPK8/AKT1/PPP3CB/MAP2K4/CDKN1A/PREX1/CREBBP/GNB1	1.55213156603243
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	13/373	217/9376	1.50588700411411	EGFR/AKT3/ADCY7/CREB3L2/BCL2/NOTCH2/AKT1/GSTA4/RPS6KA6/KPNA4/CREB5/HSP90AA1/KPNA1	1.53463743983864
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	7/373	98/9376	1.79548065875144	PLCB1/PIP5K1B/DGKI/PIP5K1A/INPP5F/INPPL1/CDS1	1.61124620514358
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	9/373	138/9376	1.63935190581653	PRKAG2/AKT3/GSK3B/PPP1CB/MAPK8/AKT1/INSR/INPPL1/ELK1	1.54005757548719
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	5/373	62/9376	2.0271555824613	PRKAG2/AKT3/ADCY7/AKT1/INSR	1.65162096810982
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	8/373	119/9376	1.68986414941312	TAB3/AKT3/CREB3L2/TRAF3/MAPK8/AKT1/MAP2K4/CREB5	1.54151712643966
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	4/373	45/9376	2.23437593089068	ABCA5/ABCD3/ABCG2/ABCC3	1.68941379466654
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/373	14/9376	3.59096131750287	FUT8/B3GNT2	1.97463603238555
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/373	29/9376	2.60035129888139	GNGT1/CNGA1/GNB1	1.75680934655624
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	8/373	122/9376	1.64831011295214	PRKAG2/AKT3/CREB3L2/TBC1D1/AKT1/INSR/CREB5/ULK1	1.46704823417182
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	8/373	122/9376	1.64831011295214	PLCB1/AKT3/GSK3B/NOTCH2/NCOA2/AKT1/ATP1B3/CREBBP	1.46704823417182
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	18/373	333/9376	1.35874212013622	EGFR/AKT3/CREB3L2/TRAF3/GSK3B/NOTCH2/DVL3/UBE3A/LAMC1/AKT1/DLG1/PARD6B/PTK2/CDKN1A/CREB5/CREBBP/RBPJ/SPP1	1.35673381938604
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	3/373	30/9376	2.51367292225201	ABCG2/MTR/ABCC3	1.69015373721431
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	5/373	65/9376	1.93359455557847	PLCB1/PBX1/ADCY7/CREB3L2/CREB5	1.53731637938035
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	4/373	48/9376	2.09472743521001	PLCB1/AKT3/AKT1/ATP1B3	1.54767148555567
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	8/373	125/9376	1.60875067024129	PLCB1/AKT3/BCL2/PRKCE/MAPK8/SGMS2/AKT1/SGPP1	1.39459000225182
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	3/373	32/9376	2.35656836461126	BCL2/BIRC6/MAPK8	1.56457608750542
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	7/373	108/9376	1.62923244960778	NUP153/TNPO1/EEF1A1/KPNA4/THOC7/UPF1/KPNA1	1.33867886053915
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	5/373	69/9376	1.82150211757392	AKT3/VAV3/MAPK8/AKT1/MAP2K4	1.39403861745496
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/373	17/9376	2.95726226147295	TXNRD1/MTR	1.64401277710579
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	5/373	70/9376	1.79548065875144	PRKAG2/AKT3/MAPK8/AKT1/ACSL4	1.35970141545773
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	7/373	110/9376	1.5996100414331	EGFR/AKT3/BCL2/AKT1/INSR/CDKN1A/CREBBP	1.2875542030004
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	4/373	52/9376	1.93359455557847	HSD17B1/CYP19A1/ADCY7/INSR	1.3740586764531
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	5/373	71/9376	1.77019219876902	AKT3/GSK3B/MAPK8/AKT1/PRLR	1.32591758359296
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	6/373	91/9376	1.6573667619244	AKT3/VAV3/GSK3B/AKT1/PPP3CB/INPPL1	1.28257837284417
Human Diseases	Cancer: specific types	hsa05218	Melanoma	5/373	73/9376	1.72169378236439	EGFR/AKT3/AKT1/CDKN1A/PDGFD	1.25993839973926
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	8/373	134/9376	1.50070025209075	PLCB1/ADCY7/ARHGEF12/PPP1CB/PPP1R12B/PRKCE/MYLK/CALD1	1.18821123963868
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	6/373	93/9376	1.62172446596904	PLCB1/EGFR/ADCY7/MAPK8/MAP2K4/ELK1	1.22642695208331
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	4/373	54/9376	1.8619799424089	AMD1/DNMT3A/APIP/MTR	1.29296247245663
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	9/373	156/9376	1.45019591668385	EGFR/AKT3/TRAF3/GSK3B/CLDN1/AKT1/YWHAZ/PIAS1/CDKN1A	1.15410366258463
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	5/373	75/9376	1.67578194816801	AKT3/BCL2/AKT1/GSTA4/CDKN1A	1.19596597721457
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	5/373	75/9376	1.67578194816801	PLCB1/ADCY7/CREB3L2/CREB5/ATP1B3	1.19596597721457
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	9/373	158/9376	1.43183900634608	AKT3/RICTOR/GSK3B/DVL3/LPIN2/AKT1/INSR/RPS6KA6/ULK1	1.11423934171889
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	7/373	116/9376	1.51687159101414	PLCB1/SLC38A1/GNGT1/ADCY7/GLS/PPP3CB/GNB1	1.14012532584574
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	3/373	37/9376	2.03811318020433	GLUD1/GLS/GFPT2	1.28778039267003
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/373	37/9376	2.03811318020433	PLCB1/THOP1/HBB	1.28778039267003
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	4/373	56/9376	1.79548065875144	MGAT5/FUT8/STT3B/MGAT4A	1.21524015402154
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	4/373	56/9376	1.79548065875144	NAIP/SEC22B/BCL2L13/EEF1A1	1.21524015402154
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	8/373	138/9376	1.45720169405914	ADCY7/PPP1CB/CPEB4/FBXW11/SPDYA/YWHAZ/PPP3CB/RPS6KA6	1.10129793319707
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	3/373	38/9376	1.98447862283053	INSR/ATP1B3/HSD11B2	1.23770624650184
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	5/373	77/9376	1.63225514431949	AKT3/CTBP2/AKT1/CDKN1A/TGFBR1	1.13387724392275
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	11/373	205/9376	1.34880010462303	AKT3/NEDD4/TRAF3/BCL2/MAPK8/AKT1/SEM1/MAP2K4/HLA-DMA/CDKN1A/RBPJ	1.02775978287491
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	11/373	205/9376	1.34880010462303	CREB3L2/TRAF3/UBE3A/SCIN/DLG1/YWHAZ/CDKN1A/CREB5/CREBBP/ACTN4/RBPJ	1.02775978287491
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	6/373	98/9376	1.53898342178695	PLCB1/ADCY7/CREB3L2/PRKCE/CREB5/ATP1B3	1.09171100948273
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/373	21/9376	2.39397421166858	COASY/DPYD	1.30163410681667
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	10/373	187/9376	1.34421011885134	PLCB1/NAIP/NEK7/TAB3/GABARAPL1/TRAF3/BCL2/MAPK8/GBP2/HSP90AA1	0.967735649269034
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	6/373	101/9376	1.49327104292199	PLCB1/ADCY7/CREB3L2/GSK3B/DVL3/CREBBP	1.01446198676276
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	4/373	60/9376	1.67578194816801	AKT3/AKT1/PPP3CB/PTK2	1.06884295929197
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	12/373	233/9376	1.2945954964388	FBN2/ANK3/DIAPH2/FBN3/PDLIM5/DAAM1/FBN1/SGCE/PLEC/SNTB1/ATP1B3/DIAPH1	0.926842912022243
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	3/373	41/9376	1.8392728699405	DAPK1/EGFR/CDKN1A	1.09618632704944
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	6/373	103/9376	1.46427548869049	PLCB1/AKT3/MAPK8/AKT1/MAP2K4/TGFBR1	0.964341079141122
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/373	23/9376	2.1858025410887	GLUD1/GLS	1.15890345213281
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/373	23/9376	2.1858025410887	LNPEP/THOP1	1.15890345213281
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	11/373	214/9376	1.29207486657814	TRIM5/AKT3/GNGT1/BCL2/MAPK8/AKT1/PAK2/FBXW11/PPP3CB/PTK2/GNB1	0.879735989273867
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	8/373	148/9376	1.35874212013622	EGFR/AKT3/GSK3B/FLT4/NOTCH2/DVL3/AKT1/CDKN1A	0.895376855705215
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	6/373	105/9376	1.43638452700115	RRAS2/AKT3/ARHGEF12/MAPK8/AKT1/PPP3CB	0.91526558207279
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	4/373	63/9376	1.59598280777905	GSK3B/GLI3/DVL3/CDKN1A	0.966063411818881
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	8/373	149/9376	1.34962304550444	PLCB1/GABRE/GNGT1/ADCY7/GABRB1/MAPK8/MGLL/GNB1	0.875607261350795
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	3/373	44/9376	1.71386790153546	FUT8/STT3B/MGAT4A	0.966058123776341
NA	NA	hsa04081	Hormone signaling	11/373	219/9376	1.26257544040055	CSHL1/CSH1/PLCB1/CSH2/GNGT1/ADCY7/GH2/PRLR/INSR/OPRK1/GNB1	0.800287404908065
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	5/373	86/9376	1.46143774549536	PLCB1/ADCY7/CREB3L2/CREB5/ATP1B3	0.874985617650801
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	4/373	65/9376	1.54687564446278	AGPAT5/DGKI/LPIN2/MGLL	0.900520339041484
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	4/373	65/9376	1.54687564446278	PLCB1/AKT3/AKT1/SPP1	0.900520339041484
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	6/373	109/9376	1.38367316821212	AKT3/TRAF3/MAPK8/AKT1/MAP2K4/SPP1	0.82007113314706
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	6/373	109/9376	1.38367316821212	MAPK8/PPP3CB/RORA/HLA-DMA/HSP90AA1/TGFBR1	0.82007113314706
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	6/373	110/9376	1.37109432122837	THSD4/FBN1/SMURF1/SMURF2/CREBBP/TGFBR1	0.796857991012279
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	10/373	201/9376	1.25058354340896	JMJD1C/PBX1/MLLT1/FUT8/HPGD/BMP2K/KDM6A/PTK2/CDKN1A/CCNT2	0.730960598372366
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	5/373	89/9376	1.41217579901798	PLCB1/EGFR/ADCY7/TJP1/PDGFD	0.795217993041815
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	6/373	112/9376	1.34661049406358	AKT3/BCL2/MAPK8/LAMC1/AKT1/HLA-DMA	0.751100194699493
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	3/373	47/9376	1.6044720780332	PRKCE/MAPK8/INSR	0.845578741721368
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	8/373	157/9376	1.28085244445962	RRAS2/AKT3/PPP1CB/AKT1/FBXW11/PPP3CB/CDKN1A/TGFBR1	0.722324849812813
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	8/373	158/9376	1.27274578341874	GSK3B/NIPBL/YWHAZ/RAD21/CDKN1A/WAPL/CREBBP/TFDP2	0.703743936298207
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	4/373	69/9376	1.45720169405914	CREB3L2/PPP1CB/PPP3CB/CREB5	0.775843182688952
Human Diseases	Substance dependence	hsa05032	Morphine addiction	5/373	91/9376	1.38113896827034	GABRE/GNGT1/ADCY7/GABRB1/GNB1	0.743634491528931
Human Diseases	Infectious disease: viral	hsa05162	Measles	7/373	136/9376	1.29380223939442	AKT3/TRAF3/GSK3B/BCL2/MAPK8/AKT1/CD46	0.70248167441161
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	8/373	160/9376	1.25683646112601	NECTIN3/NRCAM/NLGN4Y/CLDN1/PTPRM/HLA-DMA/NRXN3/CDH5	0.666947831124902
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/373	28/9376	1.79548065875144	A4GALT/B3GNT2	0.858016654041466
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	5/373	93/9376	1.3514370549742	NOTCH2/MAPK8/PPP3CB/HLA-DMA/RBPJ	0.693252235955283
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	4/373	71/9376	1.41615375901522	EGFR/TJP1/MAPK8/MAP2K4	0.716425831680049
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	4/373	71/9376	1.41615375901522	EGFR/AKT3/GLS/AKT1	0.716425831680049
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/373	29/9376	1.73356753258759	WWC1/STK3	0.805284626244801
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/373	51/9376	1.47863113073648	CEPT1/PAFAH1B1/LPCAT1	0.697602517276049
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	5/373	97/9376	1.29570769188248	PLCB1/GNGT1/ADCY7/PER3/GNB1	0.595860134421443
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/373	31/9376	1.62172446596904	IMMP2L/SEC61A1	0.705725127823833
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	4/373	76/9376	1.32298574855369	PLCB1/ADCY7/MYLK/ATP1B3	0.575433459197605
Human Diseases	Cancer: specific types	hsa05214	Glioma	4/373	76/9376	1.32298574855369	EGFR/AKT3/AKT1/CDKN1A	0.575433459197605
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	5/373	99/9376	1.26953177891516	PLCB1/ADCY7/PPP1CB/PRKCE/MAPK8	0.548744557243559
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	2/373	32/9376	1.57104557640751	BCKDHB/ACSS1	0.658606139602085
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	2/373	32/9376	1.57104557640751	ATG9B/GABARAPL1	0.658606139602085
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	3/373	55/9376	1.37109432122837	SGMS2/B4GALT5/SGPP1	0.561798827251899
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	5/373	103/9376	1.22022957390874	PABPN1/PPP1CB/SMG7/SMG1/UPF1	0.457436220811405
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	5/373	103/9376	1.22022957390874	COL17A1/SLC15A1/COL28A1/ATP1B3/COL19A1	0.457436220811405
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	6/373	128/9376	1.17828418230563	ADK/GDA/ADCY7/FHIT/RRM2B/ENTPD4	0.413371296337344
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	3/373	59/9376	1.27813877402645	DPYD/RRM2B/ENTPD4	0.436210307061372
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	2/373	36/9376	1.39648495680667	B4GALT5/ST6GALNAC3	0.48512198375038
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	8/373	180/9376	1.11718796544534	POU2F1/AKT3/TRAF3/BCL2/PPP1CB/SRPK1/AKT1/HLA-DMA	0.323121766628677
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	9/373	205/9376	1.1035637219643	PLCB1/AKT3/GSK3B/PPP1CB/MAPK8/AKT1/INSR/TGFBR1/GFPT2	0.30515652658642
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	8/373	181/9376	1.11101565624398	AKT3/ARHGEF12/BCL2/MAPK8/AKT1/PPP3CB/HLA-DMA/CREBBP	0.306968689537823
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	7/373	157/9376	1.12074588890217	GULP1/PBX1/DOCK1/ELMO1/DNMT3A/DUSP16/PTK2	0.310546544234596
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	2/373	37/9376	1.35874212013622	TFG/CDKN1A	0.44501994305223
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	4/373	85/9376	1.18290490458918	ADK/GDA/RRM2B/ENTPD4	0.344786309658989
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	4/373	86/9376	1.16915019639628	CTNNA1/CTNNA2/SGCE/SNTB1	0.320745302078992
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/373	38/9376	1.32298574855369	NMNAT2/NADK2	0.406064153395832
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/373	15/9376	1.67578194816801	ST6GALNAC3	0.53313540240093
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/373	15/9376	1.67578194816801	ALPP	0.53313540240093
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	10/373	235/9376	1.06964805202213	PRKAG2/ADCY7/CREB3L2/FRS2/RPS6KA6/MGLL/CREB5/ACSL4/ARID1A/KDM3B	0.220086031717233
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	3/373	63/9376	1.19698710583429	KMT2C/KMT5B/NSD1	0.319307928119215
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	2/373	39/9376	1.28906303705231	FTCD/MTR	0.36818629136895
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	6/373	137/9376	1.10087865208117	AKT3/BCL2/MAPK8/AKT1/NOL3/PARP4	0.24209928103256
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	4/373	88/9376	1.14257860102364	F13A1/CD59/TFPI/CD46	0.273514913171022
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/373	16/9376	1.57104557640751	A4GALT	0.465306658848086
Organismal Systems	Digestive system	hsa04976	Bile secretion	4/373	90/9376	1.11718796544534	ADCY7/ABCG2/ABCC3/ATP1B3	0.227371673569226
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	4/373	90/9376	1.11718796544534	EGFR/AKT3/AKT1/PPP3CB	0.227371673569226
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	2/373	41/9376	1.22618191329366	UIMC1/SEM1	0.29541943944402
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	2/373	41/9376	1.22618191329366	GABRE/GABRB1	0.29541943944402
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3/373	66/9376	1.14257860102364	HSD17B1/CYP19A1/HSD11B2	0.236590828684481
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/373	17/9376	1.47863113073648	GLUD1	0.402028746959638
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/373	17/9376	1.47863113073648	PCDH11Y	0.402028746959638
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	6/373	142/9376	1.06211531926141	AKT3/MAPK8/AKT1/PPP3CB/JUND/TGFBR1	0.151807905340981
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	2/373	42/9376	1.19698710583429	PCBP2/ACSL4	0.260420384315426
Organismal Systems	Digestive system	hsa04970	Salivary secretion	4/373	93/9376	1.08114964397936	PLCB1/TRPV6/ADCY7/ATP1B3	0.160077519827259
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	3/373	68/9376	1.10897334805236	AKT3/AKT1/PIM1	0.183566316057125
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	6/373	144/9376	1.047363717605	AKT3/GSK3B/DVL3/TBX3/KAT6A/AKT1	0.116580405140216
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/373	18/9376	1.39648495680667	ACSL4	0.342702975655986
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/373	18/9376	1.39648495680667	MTR	0.342702975655986
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	13/373	323/9376	1.01169498418812	EGFR/BCL2/NOTCH2/FOXP1/PRKCE/GLS/DNMT3A/MARCKS/PIM1/DICER1/CDKN1A/RDX/CREBBP	0.0435362550796534
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	2/373	44/9376	1.14257860102364	ICA1/HLA-DMA	0.192947764564411
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	2/373	44/9376	1.14257860102364	CREB3L2/CREB5	0.192947764564411
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	3/373	70/9376	1.07728839525086	SGCE/HLA-DMA/SNTB1	0.13210772539209
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	7/373	173/9376	1.01709308992856	PABPN1/AKT3/TRAF3/AKT1/HLA-DMA/CREBBP/KPNA1	0.0461875947954175
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/373	19/9376	1.32298574855369	BCKDHB	0.28683904948332
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	2/373	45/9376	1.11718796544534	KLRD1/HLA-DMA	0.160387901641445
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	9/373	227/9376	0.99661040970344	EGFR/AKT3/NFE2L2/MAPK8/AKT1/MAP2K4/GSTA4/PTK2/KEAP1	-0.0105225197985426
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/373	20/9376	1.25683646112601	LSS	0.234030789421672
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/373	20/9376	1.25683646112601	CYB5R4	0.234030789421672
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	2/373	48/9376	1.047363717605	BCKDHB/AUH	0.0669604805995513
NA	NA	hsa03272	Virion - Hepatitis viruses	2/373	48/9376	1.047363717605	EGFR/CLDN1	0.0669604805995513
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	4/373	102/9376	0.985754087157651	PLCB1/ADCY7/RAP1B/ATP1B3	-0.029444436824138
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	2/373	49/9376	1.02598894785796	CREB3L2/CREB5	0.0371246338014866
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	4/373	103/9376	0.976183659126994	PLCB1/LAMC1/PTK2/ACTN4	-0.0494686375183118
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/373	22/9376	1.14257860102364	FTCD	0.136274135548368
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	6/373	157/9376	0.960639333344717	PRKAG2/AKT3/GSK3B/MAPK8/AKT1/INSR	-0.101231761343621
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	3/373	78/9376	0.966797277789235	EEF1A1/HLA-DMA/ELK1	-0.0599339155224683
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	2/373	51/9376	0.985754087157651	TJP1/SEC61A1	-0.0207633478508303
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	2/373	52/9376	0.966797277789235	VAPA/NPC1	-0.04886756061607
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	2/373	53/9376	0.94855581971774	PLCB1/ATP1B3	-0.0764438890051291
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	3/373	82/9376	0.919636434970248	DPYD/GSTA4/RRM2B	-0.148768579257381
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	3/373	82/9376	0.919636434970248	KLRD1/HLA-DMA/HSP90AA1	-0.148768579257381
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	3/373	83/9376	0.908556477922414	FAR2/ABCD3/ACSL4	-0.170317962026944
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/373	26/9376	0.966797277789235	SLC19A3	-0.0345065062397876
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	4/373	115/9376	0.874321016435482	PLCB1/GNGT1/GABRB1/GNB1	-0.276012700844305
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/373	28/9376	0.897740329375718	ALPP	-0.110298722498349
NA	NA	hsa04082	Neuroactive ligand signaling	7/373	199/9376	0.884206555566034	PLCB1/GABRE/GNGT1/ADCY7/GABRB1/OPRK1/GNB1	-0.336052069454198
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	2/373	59/9376	0.852092516017631	GSTA4/RRM2B	-0.231966108394832
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	4/373	117/9376	0.859375358034876	MBD3/ARID2/EPC2/ARID1A	-0.311543537990775
Organismal Systems	Digestive system	hsa04978	Mineral absorption	2/373	61/9376	0.824155056476069	TRPV6/ATP1B3	-0.280446356087376
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/373	31/9376	0.81086223298452	TKT	-0.214692009257299
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/373	31/9376	0.81086223298452	DPYD	-0.214692009257299
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/373	31/9376	0.81086223298452	ACSS1	-0.214692009257299
Human Diseases	Immune disease	hsa05310	Asthma	1/373	32/9376	0.785522788203753	HLA-DMA	-0.247363808301252
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/373	33/9376	0.761719067349094	BCKDHB	-0.279093367499172
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	2/373	66/9376	0.761719067349094	RORA/HLA-DMA	-0.395396524519421
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	2/373	67/9376	0.750350126045376	MINPP1/ACSS1	-0.417410785229103
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	3/373	99/9376	0.761719067349094	PRKAG2/SGCE/SNTB1	-0.485120401807101
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	3/373	100/9376	0.754101876675603	CSF3R/CD59/HLA-DMA	-0.503177569824072
Organismal Systems	Endocrine system	hsa04924	Renin secretion	2/373	69/9376	0.728600847029568	PLCB1/PPP3CB	-0.460547686843063
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/373	37/9376	0.679371060068111	PNMT	-0.397740506565566
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/373	37/9376	0.679371060068111	GFPT2	-0.397740506565566
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	4/373	133/9376	0.755991856316394	KLRD1/VAV3/PPP3CB/SH3BP2	-0.576859559511016
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	8/373	250/9376	0.804375335120643	ABCA5/OSBPL3/ARL8B/SUMF1/CD164/GPR155/ENTPD4/NPC1	-0.638116261366571
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1/373	38/9376	0.661492874276845	GFPT2	-0.42557793971018
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	2/373	72/9376	0.698242478403336	TRAF3/MAPK8	-0.523161685742254
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	3/373	105/9376	0.718192263500575	TAB3/TRAF3/BCL2	-0.591058816297313
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	3/373	105/9376	0.718192263500575	ADCY7/SGCE/SNTB1	-0.591058816297313
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/373	39/9376	0.644531518526157	HLA-DMA	-0.452768445343363
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	5/373	168/9376	0.748116941146432	GLUD1/BCL2/MAPK8/CHMP2B/HSP90AA1	-0.670528703112516
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	2/373	75/9376	0.670312779267203	TKT/MTR	-0.583464385498545
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	2/373	76/9376	0.661492874276845	SLC27A6/ACSL4	-0.603086443256904
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/373	43/9376	0.584575098198142	ACSL4	-0.555728346520009
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/373	44/9376	0.571289300511821	PARP4	-0.58016259464752
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	3/373	116/9376	0.650087824720348	GLUD1/TKT/ACSS1	-0.771843025992866
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	1/373	46/9376	0.546450635272176	SEM1	-0.627637792100481
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	1/373	47/9376	0.534824026011066	ACSS1	-0.650721396502572
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	12/373	388/9376	0.777424615129488	PLCB1/AKT3/GSK3B/DVL3/RTN4/MAPK8/AKT1/SEM1/PPP3CB/INSR/KIF5B/ULK1	-0.911397625939798
Genetic Information Processing	Transcription	hsa03040	Spliceosome	7/373	243/9376	0.724103310936793	HNRNPA3/SNRNP70/HNRNPU/TRA2A/HNRNPC/THOC7/RBM17	-0.886929960683756
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	8/373	275/9376	0.73125030465513	CREB3L2/GSK3B/MAPK8/LAMC1/SEM1/PPP3CB/CREB5/KIF5B	-0.920695879212462
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/373	86/9376	0.584575098198142	PLCB1/SCN2A	-0.787735329064624
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	4/373	154/9376	0.652902057727795	COASY/NMNAT2/ALPP/NADK2	-0.8839877963583
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/373	50/9376	0.502734584450402	AMD1	-0.71758273499131
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	1/373	50/9376	0.502734584450402	HLA-DMA	-0.71758273499131
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	1/373	50/9376	0.502734584450402	HBB	-0.71758273499131
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	9/373	308/9376	0.734514814943769	PLCB1/CREB3L2/MAPK8/SEM1/NRF1/CREB5/KIF5B/ULK1/CREBBP	-0.964287023795321
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	4/373	155/9376	0.648689786387616	STX7/SEC22B/HLA-DMA/SEC61A1	-0.89766448519937
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	2/373	89/9376	0.564870319607193	LAMC1/SPP1	-0.839503318679311
Human Diseases	Substance dependence	hsa05034	Alcoholism	5/373	191/9376	0.658029560798956	GNGT1/CREB3L2/PPP1CB/CREB5/GNB1	-0.971878776966559
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	7/373	254/9376	0.692744506132444	PLCB1/EGFR/ADCY7/FLT4/MYLK/PPP3CB/PDGFD	-1.01045717114425
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	1/373	54/9376	0.465494985602224	HLA-DMA	-0.801752907410903
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/373	57/9376	0.440995249517897	ACSL4	-0.861617873790746
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	8/373	298/9376	0.674811522752218	CSHL1/CSH1/CSH2/CSF3R/RELL1/GH2/PRLR/TGFBR1	-1.16116682732327
Organismal Systems	Nervous system	hsa04730	Long-term depression	1/373	60/9376	0.418945487042002	PLCB1	-0.919018370975457
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	1/373	63/9376	0.398995701944764	HPGD	-0.974203039280118
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/373	63/9376	0.398995701944764	RAD23B	-0.974203039280118
NA	NA	hsa04382	Cornified envelope formation	5/373	217/9376	0.579187309274657	TJP1/CLDN1/FURIN/COL17A1/PLEC	-1.27655959748807
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	1/373	70/9376	0.359096131750287	GSTA4	-1.09548596467355
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/373	73/9376	0.344338756472878	GSTA4	-1.14465829985981
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	4/373	195/9376	0.515625214820925	PLCB1/AKT3/AKT1/CLCN3	-1.39123427397415
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	1/373	78/9376	0.322265759263078	MAPK8	-1.22337157999175
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/373	79/9376	0.318186445854685	GSTA4	-1.23866592269445
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	1/373	79/9376	0.318186445854685	SYT1	-1.23866592269445
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	9/373	368/9376	0.614756964681198	ATXN2/NUP153/BCL2/HNRNPA3/SEM1/PPP3CB/KIF5B/ULK1/CHMP2B	-1.53458498866701
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	9/373	370/9376	0.6114339540613	CSHL1/CSH1/CSH2/GABRE/GABRB1/GH2/PRLR/PGRMC2/OPRK1	-1.55219459824546
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	1/373	83/9376	0.302852159307471	ZDHHC1	-1.29847141449224
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	1/373	87/9376	0.288927922097932	ATP1B3	-1.35623578465748
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	1/373	95/9376	0.264597149710738	HLA-DMA	-1.46634497123297
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	2/373	143/9376	0.351562646468813	HLA-DMA/ACTN4	-1.59041716608742
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	1/373	99/9376	0.253906355783031	HLA-DMA	-1.51898536085776
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	5/373	268/9376	0.46896882877836	NFE2L2/MAPK8/SEM1/KIF5B/KEAP1	-1.79523922897173
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	11/373	480/9376	0.576050044682752	PLCB1/ATXN2/GSK3B/BCL2/DVL3/MAPK8/SEM1/PPP3CB/KIF5B/ULK1/CHMP2B	-1.94081551104563
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	4/373	238/9376	0.422466037353279	EGFR/TRAF3/F13A1/MAPK8	-1.83690568935409
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	1/373	183/9376	0.137359176079345	XRN1	-2.39868572645693
Cellular Processes	Cell motility	hsa04814	Motor proteins	1/373	194/9376	0.129570769188248	KIF5B	-2.49351575662415
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/373	449/9376	0.0559838067316706	GNB1	-4.17249933580793