ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0005096 GTPase activator activity 28/695 271/18639 0.103321033210332 2.77093631367968 1.17181627378668e-06 0.00110971001127599 GO:0003779 actin binding 37/695 443/18639 0.0835214446952596 2.23993698946035 4.3856234315455e-06 0.00187843234358345 GO:0106222 lncRNA binding 8/695 29/18639 0.275862068965517 7.39826345819896 7.68302884822929e-06 0.00187843234358345 GO:0045296 cadherin binding 30/695 334/18639 0.0898203592814371 2.40886572179382 8.66671823117087e-06 0.00187843234358345 GO:0141003 histone H2AX kinase activity 31/695 354/18639 0.0875706214689266 2.34853066699183 1.02560113775758e-05 0.00187843234358345 GO:0140996 histone H3 kinase activity 31/695 357/18639 0.0868347338935574 2.32879511516837 1.21301286253279e-05 0.00187843234358345 GO:0035173 histone kinase activity 31/695 360/18639 0.0861111111111111 2.30938848920863 1.43125908631626e-05 0.00187843234358345 GO:0030695 GTPase regulator activity 38/695 489/18639 0.0777096114519427 2.08407114798958 1.70581748881321e-05 0.00187843234358345 GO:0060589 nucleoside-triphosphatase regulator activity 38/695 490/18639 0.0775510204081633 2.07981794156512 1.78520497278258e-05 0.00187843234358345 GO:0051020 GTPase binding 28/695 315/18639 0.0888888888888889 2.38388489208633 2.07787224635481e-05 0.00192449517089196 GO:0003712 transcription coregulator activity 38/695 495/18639 0.0767676767676768 2.0588096795291 2.23542205700228e-05 0.00192449517089196 GO:0034987 immunoglobulin receptor binding 6/695 19/18639 0.315789473684211 8.46906474820144 4.70638100061036e-05 0.00363550300143927 GO:0140857 histone H3T45 kinase activity 23/695 246/18639 0.0934959349593496 2.50743990173715 5.1401823982217e-05 0.00363550300143927 GO:0004679 AMP-activated protein kinase activity 23/695 248/18639 0.092741935483871 2.48721861220701 5.82615119930352e-05 0.00363550300143927 GO:0031267 small GTPase binding 25/695 283/18639 0.088339222614841 2.36914355441442 6.28415268219454e-05 0.00363550300143927 GO:0004674 protein serine/threonine kinase activity 33/695 433/18639 0.0762124711316397 2.04391978334192 8.79815188064472e-05 0.00363550300143927 GO:0001221 transcription coregulator binding 14/695 115/18639 0.121739130434783 3.26488583046606 9.66814958033372e-05 0.00363550300143927 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 22/695 243/18639 0.0905349794238683 2.42803090860645 0.000119295875909099 0.00363550300143927 GO:0004676 3-phosphoinositide-dependent protein kinase activity 22/695 245/18639 0.0897959183673469 2.40821024812803 0.000134363891288674 0.00363550300143927 GO:0004711 ribosomal protein S6 kinase activity 22/695 245/18639 0.0897959183673469 2.40821024812803 0.000134363891288674 0.00363550300143927 GO:0035175 histone H3S10 kinase activity 22/695 245/18639 0.0897959183673469 2.40821024812803 0.000134363891288674 0.00363550300143927 GO:0035979 histone H2AXS139 kinase activity 22/695 245/18639 0.0897959183673469 2.40821024812803 0.000134363891288674 0.00363550300143927 GO:0044022 histone H3S28 kinase activity 22/695 245/18639 0.0897959183673469 2.40821024812803 0.000134363891288674 0.00363550300143927 GO:0044023 histone H4S1 kinase activity 22/695 245/18639 0.0897959183673469 2.40821024812803 0.000134363891288674 0.00363550300143927 GO:0044024 histone H2AS1 kinase activity 22/695 245/18639 0.0897959183673469 2.40821024812803 0.000134363891288674 0.00363550300143927 GO:0044025 histone H2BS14 kinase activity 22/695 245/18639 0.0897959183673469 2.40821024812803 0.000134363891288674 0.00363550300143927 GO:0072354 histone H3T3 kinase activity 22/695 245/18639 0.0897959183673469 2.40821024812803 0.000134363891288674 0.00363550300143927 GO:0072371 histone H2AS121 kinase activity 22/695 245/18639 0.0897959183673469 2.40821024812803 0.000134363891288674 0.00363550300143927 GO:0072518 Rho-dependent protein serine/threonine kinase activity 22/695 245/18639 0.0897959183673469 2.40821024812803 0.000134363891288674 0.00363550300143927 GO:0140823 histone H2BS36 kinase activity 22/695 245/18639 0.0897959183673469 2.40821024812803 0.000134363891288674 0.00363550300143927 GO:0140855 histone H3S57 kinase activity 22/695 245/18639 0.0897959183673469 2.40821024812803 0.000134363891288674 0.00363550300143927 GO:0140995 histone H2A kinase activity 22/695 245/18639 0.0897959183673469 2.40821024812803 0.000134363891288674 0.00363550300143927 GO:0140997 histone H4 kinase activity 22/695 245/18639 0.0897959183673469 2.40821024812803 0.000134363891288674 0.00363550300143927 GO:0140998 histone H2B kinase activity 22/695 245/18639 0.0897959183673469 2.40821024812803 0.000134363891288674 0.00363550300143927 GO:1990244 histone H2AT120 kinase activity 22/695 245/18639 0.0897959183673469 2.40821024812803 0.000134363891288674 0.00363550300143927 GO:0004677 DNA-dependent protein kinase activity 22/695 246/18639 0.0894308943089431 2.39842077557466 0.000142511951470559 0.00374885605673942 GO:0035402 histone H3T11 kinase activity 22/695 247/18639 0.0890688259109312 2.38871057000553 0.000151094533515674 0.00376543482208797 GO:0035403 histone H3T6 kinase activity 22/695 247/18639 0.0890688259109312 2.38871057000553 0.000151094533515674 0.00376543482208797 GO:0140297 DNA-binding transcription factor binding 35/695 488/18639 0.0717213114754098 1.92347269725203 0.000179054833054485 0.00434781863852812 GO:0106310 protein serine kinase activity 28/695 361/18639 0.0775623268698061 2.08012116622491 0.000221373108165305 0.0052410083358136 GO:0003714 transcription corepressor activity 19/695 204/18639 0.0931372549019608 2.49782056707575 0.000236736938594795 0.00546804587437246 GO:0061980 regulatory RNA binding 9/695 58/18639 0.155172413793103 4.16152319523691 0.000274270193075676 0.00618413982958728 GO:0019903 protein phosphatase binding 15/695 144/18639 0.104166666666667 2.79361510791367 0.000319373496101998 0.00703364420485098 GO:0005131 growth hormone receptor binding 4/695 10/18639 0.4 10.7274820143885 0.000336225470531422 0.0072364891043922 GO:0097493 structural molecule activity conferring elasticity 4/695 11/18639 0.363636363636364 9.75225637671681 0.000512798521340623 0.010791559993546 GO:0008013 beta-catenin binding 12/695 106/18639 0.113207547169811 3.03607981539297 0.000586780278460838 0.0120800200804873 GO:0051721 protein phosphatase 2A binding 6/695 30/18639 0.2 5.36374100719425 0.000725868991365212 0.0142242153982632 GO:0070566 adenylyltransferase activity 6/695 30/18639 0.2 5.36374100719425 0.000725868991365212 0.0142242153982632 GO:1990247 N6-methyladenosine-containing RNA reader activity 4/695 12/18639 0.333333333333333 8.93956834532374 0.000746580321158177 0.0142242153982632 GO:0005516 calmodulin binding 18/695 207/18639 0.0869565217391304 2.33206130747576 0.000775478471335167 0.0142242153982632 GO:0004842 ubiquitin-protein transferase activity 31/695 449/18639 0.0690423162583519 1.85162551473298 0.000777203560780907 0.0142242153982632 GO:0019902 phosphatase binding 17/695 190/18639 0.0894736842105263 2.39956834532374 0.000781055122185519 0.0142242153982632 GO:0016755 aminoacyltransferase activity 33/695 496/18639 0.0665322580645161 1.78430900440938 0.00100286507656429 0.0179191175001205 GO:0004535 poly(A)-specific ribonuclease activity 4/695 13/18639 0.307692307692308 8.2519092418373 0.00104672601372113 0.0183564728702576 GO:0019787 ubiquitin-like protein transferase activity 32/695 479/18639 0.0668058455114822 1.7916462654511 0.00111162004118244 0.0191400759818139 GO:0061659 ubiquitin-like protein ligase activity 26/695 372/18639 0.0698924731182796 1.87442562079369 0.0016850991292005 0.0284742747798227 GO:0061630 ubiquitin protein ligase activity 25/695 353/18639 0.0708215297450425 1.89934171642856 0.00171386870374857 0.0284742747798227 GO:0001222 transcription corepressor binding 7/695 49/18639 0.142857142857143 3.83124357656732 0.00213677526167992 0.0348883822898429 GO:0031625 ubiquitin protein ligase binding 22/695 302/18639 0.0728476821192053 1.95368049930916 0.00223443982275423 0.0358646527482755 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 6/695 38/18639 0.157894736842105 4.23453237410072 0.0026213426978029 0.0413735255803224 GO:0031490 chromatin DNA binding 12/695 128/18639 0.09375 2.5142535971223 0.00301844875146555 0.0468601797973423 GO:0004532 RNA exonuclease activity 6/695 40/18639 0.15 4.02280575539568 0.00342241520264202 0.0522746322080966 GO:0019208 phosphatase regulator activity 11/695 117/18639 0.094017094017094 2.52141671278362 0.0043288673761542 0.0649961058426863 GO:0035198 miRNA binding 6/695 42/18639 0.142857142857143 3.83124357656732 0.00439255625547193 0.0649961058426863 GO:1990380 K48-linked deubiquitinase activity 4/695 19/18639 0.210526315789474 5.64604316546763 0.00474909239056343 0.0691906229825164 GO:0044389 ubiquitin-like protein ligase binding 22/695 322/18639 0.0683229813664596 1.83233388444524 0.00482359488904592 0.0692112781807043 GO:0044325 transmembrane transporter binding 12/695 136/18639 0.0882352941176471 2.36635632670334 0.00493655004999443 0.0697748193633541 GO:0140030 modification-dependent protein binding 14/695 173/18639 0.0809248554913295 2.17029982950056 0.00543920844492041 0.0757489764314652 GO:0035064 methylated histone binding 8/695 74/18639 0.108108108108108 2.89931946334824 0.00619615627018134 0.085039999824083 GO:0008432 JUN kinase binding 3/695 11/18639 0.272727272727273 7.31419228253761 0.00680598835804782 0.0920752996438755 GO:0016791 phosphatase activity 19/695 273/18639 0.0695970695970696 1.86650328089177 0.0069787671583139 0.0930829929425811 GO:0140034 methylation-dependent protein binding 8/695 76/18639 0.105263157894737 2.82302158273381 0.00726734299672209 0.0955857474707753 GO:0050321 tau-protein kinase activity 4/695 22/18639 0.181818181818182 4.8761281883584 0.00820411453702745 0.1035906195542 GO:0070034 telomerase RNA binding 4/695 22/18639 0.181818181818182 4.8761281883584 0.00820411453702745 0.1035906195542 GO:0140517 protein-RNA adaptor activity 4/695 22/18639 0.181818181818182 4.8761281883584 0.00820411453702745 0.1035906195542 GO:0000175 3'-5'-RNA exonuclease activity 5/695 35/18639 0.142857142857143 3.83124357656732 0.00912732184495541 0.112254205028218 GO:0061631 ubiquitin conjugating enzyme activity 5/695 35/18639 0.142857142857143 3.83124357656732 0.00912732184495541 0.112254205028218 GO:0019209 kinase activator activity 12/695 148/18639 0.0810810810810811 2.17448959751118 0.00951299229969705 0.115497483433501 GO:0042578 phosphoric ester hydrolase activity 23/695 363/18639 0.0633608815426997 1.69925679291278 0.00967490665195708 0.115976412650675 GO:0005048 signal sequence binding 6/695 51/18639 0.117647058823529 3.15514176893779 0.0113822395339421 0.134737260483039 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 22/695 349/18639 0.0630372492836676 1.69057739481767 0.0118607929199701 0.138668776484095 GO:0008201 heparin binding 13/695 172/18639 0.0755813953488372 2.02699514806759 0.0124438839781721 0.143058817197009 GO:0016779 nucleotidyltransferase activity 11/695 136/18639 0.0808823529411765 2.16915996614473 0.0129453763754196 0.143058817197009 GO:0051117 ATPase binding 8/695 84/18639 0.0952380952380952 2.55416238437821 0.0129883852485884 0.143058817197009 GO:0008139 nuclear localization sequence binding 4/695 25/18639 0.16 4.2909928057554 0.0129916138109216 0.143058817197009 GO:0042974 nuclear retinoic acid receptor binding 4/695 25/18639 0.16 4.2909928057554 0.0129916138109216 0.143058817197009 GO:0005545 1-phosphatidylinositol binding 3/695 14/18639 0.214285714285714 5.74686536485098 0.0138150752643691 0.148669048583609 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 3/695 14/18639 0.214285714285714 5.74686536485098 0.0138150752643691 0.148669048583609 GO:0005160 transforming growth factor beta receptor binding 4/695 26/18639 0.153846153846154 4.12595462091865 0.0149108584616317 0.156561838641444 GO:0008143 poly(A) binding 4/695 26/18639 0.153846153846154 4.12595462091865 0.0149108584616317 0.156561838641444 GO:0030295 protein kinase activator activity 11/695 139/18639 0.079136690647482 2.12234356399772 0.0150444850225675 0.156561838641444 GO:0004713 protein tyrosine kinase activity 11/695 140/18639 0.0785714285714286 2.10718396711202 0.0157981205757019 0.162617610708584 GO:0120283 protein serine/threonine kinase binding 3/695 15/18639 0.2 5.36374100719425 0.0167981239884219 0.171051864699307 GO:0061650 ubiquitin-like protein conjugating enzyme activity 5/695 41/18639 0.121951219512195 3.27057378487454 0.0175624951797106 0.176932797182829 GO:0005496 steroid binding 9/695 108/18639 0.0833333333333333 2.23489208633094 0.0195928329023792 0.19530960798477 GO:0048156 tau protein binding 5/695 43/18639 0.116279069767442 3.11845407395014 0.021236293861334 0.209487190486285 GO:0045309 protein phosphorylated amino acid binding 6/695 59/18639 0.101694915254237 2.72732593586148 0.0222180818617648 0.21469921962338 GO:0070063 RNA polymerase binding 6/695 59/18639 0.101694915254237 2.72732593586148 0.0222180818617648 0.21469921962338 GO:0035591 signaling adaptor activity 10/695 129/18639 0.0775193798449612 2.07896938263343 0.0226152106029366 0.215416196226672 GO:0051219 phosphoprotein binding 8/695 93/18639 0.0860215053763441 2.30698537943838 0.0227472224104194 0.215416196226672 GO:0001223 transcription coactivator binding 5/695 44/18639 0.113636363636364 3.047580117724 0.0232471479971781 0.217970783696314 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 6/695 60/18639 0.1 2.68187050359712 0.0239357351853217 0.222226874710781 GO:0019905 syntaxin binding 6/695 61/18639 0.0983606557377049 2.63790541337422 0.025740049026957 0.235985504383679 GO:0005085 guanyl-nucleotide exchange factor activity 15/695 230/18639 0.0652173913043478 1.74904598060682 0.0259533595676643 0.235985504383679 GO:0019199 transmembrane receptor protein kinase activity 7/695 78/18639 0.0897435897435897 2.40680686220255 0.0261652354385283 0.235985504383679 GO:0050811 GABA receptor binding 3/695 18/18639 0.166666666666667 4.46978417266187 0.027738447161141 0.241950670028494 GO:0046332 SMAD binding 7/695 79/18639 0.0886075949367089 2.37634095255441 0.0278216062814433 0.241950670028494 GO:0017124 SH3 domain binding 9/695 115/18639 0.0782608695652174 2.09885517672818 0.0281040904996139 0.241950670028494 GO:0035401 histone H3Y41 kinase activity 9/695 115/18639 0.0782608695652174 2.09885517672818 0.0281040904996139 0.241950670028494 GO:0140801 histone H2AXY142 kinase activity 9/695 115/18639 0.0782608695652174 2.09885517672818 0.0281040904996139 0.241950670028494 GO:0070717 poly-purine tract binding 4/695 32/18639 0.125 3.3523381294964 0.0301170807220277 0.25694482381766 GO:0003713 transcription coactivator activity 16/695 256/18639 0.0625 1.6761690647482 0.0309498968345759 0.258115235943774 GO:0140789 histone phosphatase activity 10/695 136/18639 0.0735294117647059 1.97196360558612 0.0311333272411391 0.258115235943774 GO:0004721 phosphoprotein phosphatase activity 12/695 175/18639 0.0685714285714286 1.83899691675231 0.0312401788920132 0.258115235943774 GO:0015101 organic cation transmembrane transporter activity 7/695 81/18639 0.0864197530864197 2.31766586730615 0.0313445112286527 0.258115235943774 GO:0140036 ubiquitin-modified protein reader activity 3/695 19/18639 0.157894736842105 4.23453237410072 0.0320489511806243 0.261641006621132 GO:0140416 transcription regulator inhibitor activity 4/695 33/18639 0.121212121212121 3.25075212557227 0.0332929012549358 0.269473311866874 GO:0051427 hormone receptor binding 4/695 34/18639 0.117647058823529 3.15514176893779 0.0366565639084752 0.284779430394673 GO:0052866 phosphatidylinositol phosphate phosphatase activity 4/695 34/18639 0.117647058823529 3.15514176893779 0.0366565639084752 0.284779430394673 GO:0000339 RNA cap binding 3/695 20/18639 0.15 4.02280575539568 0.0366875295756601 0.284779430394673 GO:0052745 inositol phosphate phosphatase activity 3/695 20/18639 0.15 4.02280575539568 0.0366875295756601 0.284779430394673 GO:0061608 nuclear import signal receptor activity 3/695 20/18639 0.15 4.02280575539568 0.0366875295756601 0.284779430394673 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 3/695 21/18639 0.142857142857143 3.83124357656732 0.0416499511693611 0.318084707720847 GO:0051010 microtubule plus-end binding 3/695 21/18639 0.142857142857143 3.83124357656732 0.0416499511693611 0.318084707720847 GO:0030159 signaling receptor complex adaptor activity 5/695 52/18639 0.0961538461538462 2.57872163807416 0.0437643391573733 0.33155863345626 GO:0042393 histone binding 15/695 247/18639 0.0607287449392713 1.62866629773105 0.044288998559019 0.332332517303534 GO:0000149 SNARE binding 8/695 106/18639 0.0754716981132075 2.02405321026198 0.0445683523733356 0.332332517303534 GO:0008028 monocarboxylic acid transmembrane transporter activity 6/695 70/18639 0.0857142857142857 2.29874614594039 0.0461019003429886 0.334161928477552 GO:0019888 protein phosphatase regulator activity 8/695 107/18639 0.0747663551401869 2.00513682511934 0.0466708147942109 0.334161928477552 GO:0051018 protein kinase A binding 5/695 53/18639 0.0943396226415094 2.53006651282747 0.0469028920431366 0.334161928477552 GO:0008093 cytoskeletal anchor activity 3/695 22/18639 0.136363636363636 3.6570961412688 0.0469308727428875 0.334161928477552 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 3/695 22/18639 0.136363636363636 3.6570961412688 0.0469308727428875 0.334161928477552 GO:0140035 ubiquitin-like protein reader activity 3/695 22/18639 0.136363636363636 3.6570961412688 0.0469308727428875 0.334161928477552 GO:0003727 single-stranded RNA binding 7/695 89/18639 0.0786516853932584 2.1093363511438 0.0483783111479273 0.340686256575182 GO:0051015 actin filament binding 13/695 209/18639 0.062200956937799 1.66814911706998 0.0499279656506188 0.340686256575182 GO:0140463 chromatin-protein adaptor activity 5/695 54/18639 0.0925925925925926 2.48321342925659 0.0501716237739675 0.340686256575182 GO:0016247 channel regulator activity 11/695 168/18639 0.0654761904761905 1.75598663926002 0.0502777781443345 0.340686256575182 GO:0004862 cAMP-dependent protein kinase inhibitor activity 2/695 10/18639 0.2 5.36374100719425 0.0512273393659896 0.340686256575182 GO:0031957 very long-chain fatty acid-CoA ligase activity 2/695 10/18639 0.2 5.36374100719425 0.0512273393659896 0.340686256575182 GO:0050815 phosphoserine residue binding 2/695 10/18639 0.2 5.36374100719425 0.0512273393659896 0.340686256575182 GO:0070097 delta-catenin binding 2/695 10/18639 0.2 5.36374100719425 0.0512273393659896 0.340686256575182 GO:0099122 RNA polymerase II C-terminal domain binding 2/695 10/18639 0.2 5.36374100719425 0.0512273393659896 0.340686256575182 GO:0042162 telomeric DNA binding 4/695 38/18639 0.105263157894737 2.82302158273381 0.0519961895431657 0.340686256575182 GO:0042171 lysophosphatidic acid acyltransferase activity 3/695 23/18639 0.130434782608696 3.49809196121364 0.0525239635269025 0.340686256575182 GO:0071617 lysophospholipid acyltransferase activity 3/695 23/18639 0.130434782608696 3.49809196121364 0.0525239635269025 0.340686256575182 GO:0140103 catalytic activity, acting on a glycoprotein 3/695 23/18639 0.130434782608696 3.49809196121364 0.0525239635269025 0.340686256575182 GO:1901681 sulfur compound binding 16/695 275/18639 0.0581818181818182 1.56036102027469 0.0532760307786984 0.342095093249952 GO:0015631 tubulin binding 21/695 385/18639 0.0545454545454545 1.46283845650752 0.0534636470971413 0.342095093249952 GO:0141108 transporter regulator activity 11/695 170/18639 0.0647058823529412 1.73532797291579 0.0538808226303131 0.342450597522863 GO:0019887 protein kinase regulator activity 15/695 255/18639 0.0588235294117647 1.5775708844689 0.0555121298344157 0.350466579687945 GO:0030215 semaphorin receptor binding 3/695 24/18639 0.125 3.3523381294964 0.0584220206561812 0.361628230712063 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 2/695 11/18639 0.181818181818182 4.8761281883584 0.0610987507010878 0.361628230712063 GO:0005114 type II transforming growth factor beta receptor binding 2/695 11/18639 0.181818181818182 4.8761281883584 0.0610987507010878 0.361628230712063 GO:0005225 volume-sensitive anion channel activity 2/695 11/18639 0.181818181818182 4.8761281883584 0.0610987507010878 0.361628230712063 GO:0008172 S-methyltransferase activity 2/695 11/18639 0.181818181818182 4.8761281883584 0.0610987507010878 0.361628230712063 GO:0032050 clathrin heavy chain binding 2/695 11/18639 0.181818181818182 4.8761281883584 0.0610987507010878 0.361628230712063 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 2/695 11/18639 0.181818181818182 4.8761281883584 0.0610987507010878 0.361628230712063 GO:0047676 arachidonate-CoA ligase activity 2/695 11/18639 0.181818181818182 4.8761281883584 0.0610987507010878 0.361628230712063 GO:0048185 activin binding 2/695 11/18639 0.181818181818182 4.8761281883584 0.0610987507010878 0.361628230712063 GO:0140537 transcription regulator activator activity 2/695 11/18639 0.181818181818182 4.8761281883584 0.0610987507010878 0.361628230712063 GO:0008408 3'-5' exonuclease activity 5/695 58/18639 0.0862068965517241 2.31195733068717 0.0645505783636332 0.364306534808098 GO:0015645 fatty acid ligase activity 3/695 25/18639 0.12 3.21824460431655 0.0646170761350803 0.364306534808098 GO:0019211 phosphatase activator activity 3/695 25/18639 0.12 3.21824460431655 0.0646170761350803 0.364306534808098 GO:0019706 protein-cysteine S-palmitoyltransferase activity 3/695 25/18639 0.12 3.21824460431655 0.0646170761350803 0.364306534808098 GO:0019707 protein-cysteine S-acyltransferase activity 3/695 25/18639 0.12 3.21824460431655 0.0646170761350803 0.364306534808098 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 3/695 25/18639 0.12 3.21824460431655 0.0646170761350803 0.364306534808098 GO:0120515 fatty acid-CoA ligase activity 3/695 25/18639 0.12 3.21824460431655 0.0646170761350803 0.364306534808098 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 4/695 41/18639 0.0975609756097561 2.61645902789963 0.0654630161858886 0.364306534808098 GO:0016877 ligase activity, forming carbon-sulfur bonds 4/695 41/18639 0.0975609756097561 2.61645902789963 0.0654630161858886 0.364306534808098 GO:0017080 sodium channel regulator activity 4/695 41/18639 0.0975609756097561 2.61645902789963 0.0654630161858886 0.364306534808098 GO:0035091 phosphatidylinositol binding 16/695 284/18639 0.0563380281690141 1.51091295977303 0.0670319098196243 0.364306534808098 GO:0031593 polyubiquitin modification-dependent protein binding 5/695 59/18639 0.0847457627118644 2.2727716132179 0.068470253965658 0.364306534808098 GO:0005319 lipid transporter activity 11/695 178/18639 0.0617977528089888 1.65733570447013 0.0700004795897131 0.364306534808098 GO:0016922 nuclear receptor binding 9/695 137/18639 0.0656934306569343 1.76181273958935 0.070849412550431 0.364306534808098 GO:0030507 spectrin binding 3/695 26/18639 0.115384615384615 3.09446596568899 0.0711004958316171 0.364306534808098 GO:0000340 RNA 7-methylguanosine cap binding 2/695 12/18639 0.166666666666667 4.46978417266187 0.0715533426339032 0.364306534808098 GO:0008603 cAMP-dependent protein kinase regulator activity 2/695 12/18639 0.166666666666667 4.46978417266187 0.0715533426339032 0.364306534808098 GO:0016208 AMP binding 2/695 12/18639 0.166666666666667 4.46978417266187 0.0715533426339032 0.364306534808098 GO:0034452 dynactin binding 2/695 12/18639 0.166666666666667 4.46978417266187 0.0715533426339032 0.364306534808098 GO:0035197 siRNA binding 2/695 12/18639 0.166666666666667 4.46978417266187 0.0715533426339032 0.364306534808098 GO:0035497 cAMP response element binding 2/695 12/18639 0.166666666666667 4.46978417266187 0.0715533426339032 0.364306534808098 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 2/695 12/18639 0.166666666666667 4.46978417266187 0.0715533426339032 0.364306534808098 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 2/695 12/18639 0.166666666666667 4.46978417266187 0.0715533426339032 0.364306534808098 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 2/695 12/18639 0.166666666666667 4.46978417266187 0.0715533426339032 0.364306534808098 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 2/695 12/18639 0.166666666666667 4.46978417266187 0.0715533426339032 0.364306534808098 GO:1990817 poly(A) RNA polymerase activity 2/695 12/18639 0.166666666666667 4.46978417266187 0.0715533426339032 0.364306534808098 GO:0019207 kinase regulator activity 16/695 287/18639 0.0557491289198606 1.49511944451408 0.0721040475188714 0.365147235296103 GO:0004714 transmembrane receptor protein tyrosine kinase activity 5/695 60/18639 0.0833333333333333 2.23489208633094 0.0725188465820523 0.365294402729806 GO:0004725 protein tyrosine phosphatase activity 7/695 98/18639 0.0714285714285714 1.91562178828366 0.0734832121212294 0.368193660734414 GO:0004712 protein serine/threonine/tyrosine kinase activity 4/695 43/18639 0.0930232558139535 2.49476325916011 0.0753518416329064 0.375569442244012 GO:0099106 ion channel regulator activity 10/695 160/18639 0.0625 1.6761690647482 0.0768272660813332 0.380918434445144 GO:0016405 CoA-ligase activity 3/695 27/18639 0.111111111111111 2.97985611510791 0.0778630709894872 0.384043376182523 GO:0043130 ubiquitin binding 7/695 100/18639 0.07 1.87730935251799 0.0799383644679205 0.390798676452568 GO:0016248 channel inhibitor activity 4/695 44/18639 0.0909090909090909 2.4380640941792 0.0805623109964792 0.390798676452568 GO:0005172 vascular endothelial growth factor receptor binding 2/695 13/18639 0.153846153846154 4.12595462091865 0.0825340393775223 0.390798676452568 GO:0035673 oligopeptide transmembrane transporter activity 2/695 13/18639 0.153846153846154 4.12595462091865 0.0825340393775223 0.390798676452568 GO:0046975 histone H3K36 methyltransferase activity 2/695 13/18639 0.153846153846154 4.12595462091865 0.0825340393775223 0.390798676452568 GO:0070123 transforming growth factor beta receptor activity, type III 2/695 13/18639 0.153846153846154 4.12595462091865 0.0825340393775223 0.390798676452568 GO:0071714 icosanoid transmembrane transporter activity 2/695 13/18639 0.153846153846154 4.12595462091865 0.0825340393775223 0.390798676452568 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 2/695 13/18639 0.153846153846154 4.12595462091865 0.0825340393775223 0.390798676452568 GO:0004540 RNA nuclease activity 8/695 121/18639 0.0661157024793388 1.77313752303942 0.0829633848552028 0.390877241083966 GO:0045499 chemorepellent activity 3/695 28/18639 0.107142857142857 2.87343268242549 0.084895102720379 0.394096383706857 GO:0046966 nuclear thyroid hormone receptor binding 3/695 28/18639 0.107142857142857 2.87343268242549 0.084895102720379 0.394096383706857 GO:0141052 histone H3 demethylase activity 3/695 28/18639 0.107142857142857 2.87343268242549 0.084895102720379 0.394096383706857 GO:0141110 transporter inhibitor activity 4/695 45/18639 0.0888888888888889 2.38388489208633 0.0859462428341196 0.397029716897128 GO:1901981 phosphatidylinositol phosphate binding 11/695 185/18639 0.0594594594594595 1.59462570484153 0.0864037233097261 0.397205465894712 GO:0030291 protein serine/threonine kinase inhibitor activity 4/695 46/18639 0.0869565217391304 2.33206130747576 0.0915003692625343 0.41255734618489 GO:0003785 actin monomer binding 3/695 29/18639 0.103448275862069 2.77434879682461 0.092186479913362 0.41255734618489 GO:0016417 S-acyltransferase activity 3/695 29/18639 0.103448275862069 2.77434879682461 0.092186479913362 0.41255734618489 GO:0035250 UDP-galactosyltransferase activity 3/695 29/18639 0.103448275862069 2.77434879682461 0.092186479913362 0.41255734618489 GO:0004527 exonuclease activity 6/695 84/18639 0.0714285714285714 1.91562178828366 0.0934446788156113 0.41255734618489 GO:0008559 ABC-type xenobiotic transporter activity 2/695 14/18639 0.142857142857143 3.83124357656732 0.0939872000630478 0.41255734618489 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 2/695 14/18639 0.142857142857143 3.83124357656732 0.0939872000630478 0.41255734618489 GO:0032454 histone H3K9 demethylase activity 2/695 14/18639 0.142857142857143 3.83124357656732 0.0939872000630478 0.41255734618489 GO:0046030 inositol trisphosphate phosphatase activity 2/695 14/18639 0.142857142857143 3.83124357656732 0.0939872000630478 0.41255734618489 GO:0046943 carboxylic acid transmembrane transporter activity 11/695 188/18639 0.0585106382978723 1.56917954997704 0.0940996692459728 0.41255734618489 GO:0005342 organic acid transmembrane transporter activity 11/695 189/18639 0.0582010582010582 1.56087701267557 0.0967538897428145 0.420403894881559 GO:0001784 phosphotyrosine residue binding 4/695 47/18639 0.0851063829787234 2.28244298178479 0.0972211752682803 0.420403894881559 GO:0140359 ABC-type transporter activity 4/695 47/18639 0.0851063829787234 2.28244298178479 0.0972211752682803 0.420403894881559 GO:0005201 extracellular matrix structural constituent 10/695 168/18639 0.0595238095238095 1.59635149023638 0.0982908633069193 0.423097488871148 GO:0008187 poly-pyrimidine tract binding 3/695 30/18639 0.1 2.68187050359712 0.0997267509738676 0.423503287767949 GO:0032452 histone demethylase activity 3/695 30/18639 0.1 2.68187050359712 0.0997267509738676 0.423503287767949 GO:0033612 receptor serine/threonine kinase binding 3/695 30/18639 0.1 2.68187050359712 0.0997267509738676 0.423503287767949 GO:0140693 molecular condensate scaffold activity 4/695 48/18639 0.0833333333333333 2.23489208633094 0.103104916773078 0.435894447250467 GO:0004467 long-chain fatty acid-CoA ligase activity 2/695 15/18639 0.133333333333333 3.5758273381295 0.105862442536067 0.439700583691472 GO:0005402 carbohydrate:monoatomic cation symporter activity 2/695 15/18639 0.133333333333333 3.5758273381295 0.105862442536067 0.439700583691472 GO:0051371 muscle alpha-actinin binding 2/695 15/18639 0.133333333333333 3.5758273381295 0.105862442536067 0.439700583691472 GO:0061578 K63-linked deubiquitinase activity 2/695 15/18639 0.133333333333333 3.5758273381295 0.105862442536067 0.439700583691472 GO:0016411 acylglycerol O-acyltransferase activity 3/695 31/18639 0.0967741935483871 2.59535855186818 0.107505189781765 0.440724739062039 GO:0016878 acid-thiol ligase activity 3/695 31/18639 0.0967741935483871 2.59535855186818 0.107505189781765 0.440724739062039 GO:0140457 protein demethylase activity 3/695 31/18639 0.0967741935483871 2.59535855186818 0.107505189781765 0.440724739062039 GO:0032934 sterol binding 5/695 68/18639 0.0735294117647059 1.97196360558612 0.109415578765005 0.446623073665774 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 6/695 89/18639 0.0674157303370786 1.80800258669469 0.114959808931333 0.456540874641379 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 6/695 89/18639 0.0674157303370786 1.80800258669469 0.114959808931333 0.456540874641379 GO:0008378 galactosyltransferase activity 3/695 32/18639 0.09375 2.5142535971223 0.11551085623622 0.456540874641379 GO:0042910 xenobiotic transmembrane transporter activity 3/695 32/18639 0.09375 2.5142535971223 0.11551085623622 0.456540874641379 GO:0051059 NF-kappaB binding 3/695 32/18639 0.09375 2.5142535971223 0.11551085623622 0.456540874641379 GO:0120015 sterol transfer activity 3/695 32/18639 0.09375 2.5142535971223 0.11551085623622 0.456540874641379 GO:0140142 nucleocytoplasmic carrier activity 3/695 32/18639 0.09375 2.5142535971223 0.11551085623622 0.456540874641379 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 2/695 16/18639 0.125 3.3523381294964 0.118112475488002 0.456540874641379 GO:0005024 transforming growth factor beta receptor activity 2/695 16/18639 0.125 3.3523381294964 0.118112475488002 0.456540874641379 GO:0005324 long-chain fatty acid transmembrane transporter activity 2/695 16/18639 0.125 3.3523381294964 0.118112475488002 0.456540874641379 GO:0034450 ubiquitin-ubiquitin ligase activity 2/695 16/18639 0.125 3.3523381294964 0.118112475488002 0.456540874641379 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 2/695 16/18639 0.125 3.3523381294964 0.118112475488002 0.456540874641379 GO:0070411 I-SMAD binding 2/695 16/18639 0.125 3.3523381294964 0.118112475488002 0.456540874641379 GO:0140793 histone H2AXY142 phosphatase activity 6/695 90/18639 0.0666666666666667 1.78791366906475 0.119538985411539 0.459448479373234 GO:0097110 scaffold protein binding 5/695 70/18639 0.0714285714285714 1.91562178828366 0.119835031050886 0.459448479373234 GO:0005539 glycosaminoglycan binding 13/695 242/18639 0.0537190082644628 1.44067423746953 0.1203473349641 0.45955212181856 GO:0005010 insulin-like growth factor receptor activity 4/695 51/18639 0.0784313725490196 2.10342784595853 0.121693248191349 0.462825325450632 GO:0071889 14-3-3 protein binding 3/695 33/18639 0.0909090909090909 2.4380640941792 0.123732651734349 0.468699284769712 GO:0043022 ribosome binding 7/695 112/18639 0.0625 1.6761690647482 0.125242750423622 0.472529420920997 GO:0008429 phosphatidylethanolamine binding 2/695 17/18639 0.117647058823529 3.15514176893779 0.130692938547126 0.483461768766126 GO:0038191 neuropilin binding 2/695 17/18639 0.117647058823529 3.15514176893779 0.130692938547126 0.483461768766126 GO:0046965 nuclear retinoid X receptor binding 2/695 17/18639 0.117647058823529 3.15514176893779 0.130692938547126 0.483461768766126 GO:0070403 NAD+ binding 2/695 17/18639 0.117647058823529 3.15514176893779 0.130692938547126 0.483461768766126 GO:1990226 histone methyltransferase binding 2/695 17/18639 0.117647058823529 3.15514176893779 0.130692938547126 0.483461768766126 GO:0090482 vitamin transmembrane transporter activity 3/695 34/18639 0.0882352941176471 2.36635632670334 0.132159369911046 0.4869841373765 GO:0005003 ephrin receptor activity 4/695 53/18639 0.0754716981132075 2.02405321026198 0.134822787772837 0.492962085022689 GO:0005005 transmembrane-ephrin receptor activity 4/695 53/18639 0.0754716981132075 2.02405321026198 0.134822787772837 0.492962085022689 GO:0002020 protease binding 8/695 136/18639 0.0588235294117647 1.5775708844689 0.136161464453155 0.494527534219015 GO:0043539 protein serine/threonine kinase activator activity 5/695 73/18639 0.0684931506849315 1.83689760520351 0.136295339420447 0.494527534219015 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 23/695 484/18639 0.0475206611570248 1.27444259468458 0.140327901129582 0.499828862948325 GO:0140566 histone reader activity 3/695 35/18639 0.0857142857142857 2.29874614594039 0.140779742948825 0.499828862948325 GO:0015485 cholesterol binding 4/695 54/18639 0.0740740740740741 1.98657074340528 0.141594880892746 0.499828862948325 GO:0051287 NAD binding 4/695 54/18639 0.0740740740740741 1.98657074340528 0.141594880892746 0.499828862948325 GO:0031491 nucleosome binding 5/695 74/18639 0.0675675675675676 1.81207466459265 0.141994134735612 0.499828862948325 GO:0000900 mRNA regulatory element binding translation repressor activity 2/695 18/18639 0.111111111111111 2.97985611510791 0.143562249970374 0.499828862948325 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 2/695 18/18639 0.111111111111111 2.97985611510791 0.143562249970374 0.499828862948325 GO:0017075 syntaxin-1 binding 2/695 18/18639 0.111111111111111 2.97985611510791 0.143562249970374 0.499828862948325 GO:0022851 GABA-gated chloride ion channel activity 2/695 18/18639 0.111111111111111 2.97985611510791 0.143562249970374 0.499828862948325 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 2/695 18/18639 0.111111111111111 2.97985611510791 0.143562249970374 0.499828862948325 GO:1990381 ubiquitin-specific protease binding 2/695 18/18639 0.111111111111111 2.97985611510791 0.143562249970374 0.499828862948325 GO:0003725 double-stranded RNA binding 5/695 75/18639 0.0666666666666667 1.78791366906475 0.147794666845291 0.507722624050776 GO:0004866 endopeptidase inhibitor activity 9/695 161/18639 0.0559006211180124 1.49918226909156 0.148232854691821 0.507722624050776 GO:0008374 O-acyltransferase activity 4/695 55/18639 0.0727272727272727 1.95045127534336 0.148498731300817 0.507722624050776 GO:0000993 RNA polymerase II complex binding 3/695 36/18639 0.0833333333333333 2.23489208633094 0.149582483748856 0.507722624050776 GO:0004869 cysteine-type endopeptidase inhibitor activity 3/695 36/18639 0.0833333333333333 2.23489208633094 0.149582483748856 0.507722624050776 GO:0005484 SNAP receptor activity 3/695 36/18639 0.0833333333333333 2.23489208633094 0.149582483748856 0.507722624050776 GO:0016409 palmitoyltransferase activity 3/695 36/18639 0.0833333333333333 2.23489208633094 0.149582483748856 0.507722624050776 GO:0008017 microtubule binding 14/695 276/18639 0.0507246376811594 1.36036909602753 0.151966672282949 0.513972995185546 GO:0017022 myosin binding 5/695 76/18639 0.0657894736842105 1.76438848920863 0.153694244795369 0.516994230412142 GO:0170055 lipid transmembrane transporter activity 4/695 56/18639 0.0714285714285714 1.91562178828366 0.155529368433192 0.516994230412142 GO:0001216 DNA-binding transcription activator activity 23/695 491/18639 0.0468431771894094 1.25627335199051 0.155542357081349 0.516994230412142 GO:0004890 GABA-A receptor activity 2/695 19/18639 0.105263157894737 2.82302158273381 0.156681461592698 0.516994230412142 GO:0015245 fatty acid transmembrane transporter activity 2/695 19/18639 0.105263157894737 2.82302158273381 0.156681461592698 0.516994230412142 GO:0030506 ankyrin binding 2/695 19/18639 0.105263157894737 2.82302158273381 0.156681461592698 0.516994230412142 GO:0042577 lipid phosphatase activity 2/695 19/18639 0.105263157894737 2.82302158273381 0.156681461592698 0.516994230412142 GO:0023023 MHC protein complex binding 3/695 37/18639 0.0810810810810811 2.17448959751118 0.158556324237734 0.521364024490049 GO:0032182 ubiquitin-like protein binding 7/695 120/18639 0.0583333333333333 1.56442446043165 0.161328449686356 0.528643743435913 GO:0042887 amide transmembrane transporter activity 3/695 38/18639 0.0789473684210526 2.11726618705036 0.167690050068697 0.54759474970709 GO:0015095 magnesium ion transmembrane transporter activity 2/695 20/18639 0.1 2.68187050359712 0.170014120705702 0.549499564192149 GO:0043024 ribosomal small subunit binding 2/695 20/18639 0.1 2.68187050359712 0.170014120705702 0.549499564192149 GO:0140939 histone H4 methyltransferase activity 2/695 20/18639 0.1 2.68187050359712 0.170014120705702 0.549499564192149 GO:0015459 potassium channel regulator activity 4/695 59/18639 0.0677966101694915 1.81821729057432 0.177331108976663 0.550163249241123 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 4/695 59/18639 0.0677966101694915 1.81821729057432 0.177331108976663 0.550163249241123 GO:0030414 peptidase inhibitor activity 9/695 169/18639 0.0532544378698225 1.42821506108723 0.18082309159707 0.550163249241123 GO:0005248 voltage-gated sodium channel activity 2/695 21/18639 0.0952380952380952 2.55416238437821 0.183526138551632 0.550163249241123 GO:0015125 bile acid transmembrane transporter activity 2/695 21/18639 0.0952380952380952 2.55416238437821 0.183526138551632 0.550163249241123 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 2/695 21/18639 0.0952380952380952 2.55416238437821 0.183526138551632 0.550163249241123 GO:0061891 calcium ion sensor activity 2/695 21/18639 0.0952380952380952 2.55416238437821 0.183526138551632 0.550163249241123 GO:0072542 protein phosphatase activator activity 2/695 21/18639 0.0952380952380952 2.55416238437821 0.183526138551632 0.550163249241123 GO:0033192 calmodulin-dependent protein phosphatase activity 5/695 81/18639 0.0617283950617284 1.6554756195044 0.184578726762099 0.550163249241123 GO:0140791 histone H2AXS140 phosphatase activity 5/695 81/18639 0.0617283950617284 1.6554756195044 0.184578726762099 0.550163249241123 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 5/695 81/18639 0.0617283950617284 1.6554756195044 0.184578726762099 0.550163249241123 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 5/695 81/18639 0.0617283950617284 1.6554756195044 0.184578726762099 0.550163249241123 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 5/695 81/18639 0.0617283950617284 1.6554756195044 0.184578726762099 0.550163249241123 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 5/695 81/18639 0.0617283950617284 1.6554756195044 0.184578726762099 0.550163249241123 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 5/695 81/18639 0.0617283950617284 1.6554756195044 0.184578726762099 0.550163249241123 GO:1990439 MAP kinase serine/threonine phosphatase activity 5/695 81/18639 0.0617283950617284 1.6554756195044 0.184578726762099 0.550163249241123 GO:0001098 basal transcription machinery binding 4/695 60/18639 0.0666666666666667 1.78791366906475 0.184817699147707 0.550163249241123 GO:0001099 basal RNA polymerase II transcription machinery binding 4/695 60/18639 0.0666666666666667 1.78791366906475 0.184817699147707 0.550163249241123 GO:0030331 nuclear estrogen receptor binding 3/695 40/18639 0.075 2.01140287769784 0.186392753907252 0.550163249241123 GO:0032451 demethylase activity 3/695 40/18639 0.075 2.01140287769784 0.186392753907252 0.550163249241123 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 3/695 40/18639 0.075 2.01140287769784 0.186392753907252 0.550163249241123 GO:0061791 GTPase motor activity 3/695 40/18639 0.075 2.01140287769784 0.186392753907252 0.550163249241123 GO:0071949 FAD binding 3/695 40/18639 0.075 2.01140287769784 0.186392753907252 0.550163249241123 GO:1990606 membrane scission GTPase motor activity 3/695 40/18639 0.075 2.01140287769784 0.186392753907252 0.550163249241123 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 5/695 82/18639 0.0609756097560976 1.63528689243727 0.19101228886065 0.550163249241123 GO:0033549 MAP kinase phosphatase activity 5/695 82/18639 0.0609756097560976 1.63528689243727 0.19101228886065 0.550163249241123 GO:0016836 hydro-lyase activity 4/695 61/18639 0.0655737704918033 1.75860360891615 0.192405220145077 0.550163249241123 GO:0001727 lipid kinase activity 3/695 41/18639 0.0731707317073171 1.96234427092472 0.195939838464202 0.550163249241123 GO:0042169 SH2 domain binding 3/695 41/18639 0.0731707317073171 1.96234427092472 0.195939838464202 0.550163249241123 GO:0140318 protein transporter activity 3/695 41/18639 0.0731707317073171 1.96234427092472 0.195939838464202 0.550163249241123 GO:0042826 histone deacetylase binding 7/695 127/18639 0.0551181102362205 1.47819634056534 0.196287074883829 0.550163249241123 GO:0032931 histone H3K56 acetyltransferase activity 2/695 22/18639 0.0909090909090909 2.4380640941792 0.197185665132507 0.550163249241123 GO:0043992 histone H3K9 acetyltransferase activity 2/695 22/18639 0.0909090909090909 2.4380640941792 0.197185665132507 0.550163249241123 GO:0043993 histone H3K18 acetyltransferase activity 2/695 22/18639 0.0909090909090909 2.4380640941792 0.197185665132507 0.550163249241123 GO:0043994 histone H3K23 acetyltransferase activity 2/695 22/18639 0.0909090909090909 2.4380640941792 0.197185665132507 0.550163249241123 GO:0043999 histone H2AK5 acetyltransferase activity 2/695 22/18639 0.0909090909090909 2.4380640941792 0.197185665132507 0.550163249241123 GO:0044012 histone H2AK9 acetyltransferase activity 2/695 22/18639 0.0909090909090909 2.4380640941792 0.197185665132507 0.550163249241123 GO:0044014 histone H2BK5 acetyltransferase activity 2/695 22/18639 0.0909090909090909 2.4380640941792 0.197185665132507 0.550163249241123 GO:0044015 histone H2BK12 acetyltransferase activity 2/695 22/18639 0.0909090909090909 2.4380640941792 0.197185665132507 0.550163249241123 GO:0044016 histone H3K4 acetyltransferase activity 2/695 22/18639 0.0909090909090909 2.4380640941792 0.197185665132507 0.550163249241123 GO:0044017 histone H3K27 acetyltransferase activity 2/695 22/18639 0.0909090909090909 2.4380640941792 0.197185665132507 0.550163249241123 GO:0044018 histone H3K36 acetyltransferase activity 2/695 22/18639 0.0909090909090909 2.4380640941792 0.197185665132507 0.550163249241123 GO:0046972 histone H4K16 acetyltransferase activity 2/695 22/18639 0.0909090909090909 2.4380640941792 0.197185665132507 0.550163249241123 GO:0140784 metal ion sensor activity 2/695 22/18639 0.0909090909090909 2.4380640941792 0.197185665132507 0.550163249241123 GO:0140908 histone H3K122 acetyltransferase activity 2/695 22/18639 0.0909090909090909 2.4380640941792 0.197185665132507 0.550163249241123 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 5/695 83/18639 0.0602409638554217 1.61558464072116 0.197524292230182 0.550163249241123 GO:0030165 PDZ domain binding 5/695 83/18639 0.0602409638554217 1.61558464072116 0.197524292230182 0.550163249241123 GO:0015179 L-amino acid transmembrane transporter activity 4/695 62/18639 0.0645161290322581 1.73023903457879 0.200088387548195 0.555670683308329 GO:0017018 myosin phosphatase activity 5/695 84/18639 0.0595238095238095 1.59635149023638 0.204111609534901 0.562734412303328 GO:0019894 kinesin binding 3/695 42/18639 0.0714285714285714 1.91562178828366 0.205603069331522 0.562734412303328 GO:0031492 nucleosomal DNA binding 3/695 42/18639 0.0714285714285714 1.91562178828366 0.205603069331522 0.562734412303328 GO:0043175 RNA polymerase core enzyme binding 3/695 42/18639 0.0714285714285714 1.91562178828366 0.205603069331522 0.562734412303328 GO:0048487 beta-tubulin binding 3/695 42/18639 0.0714285714285714 1.91562178828366 0.205603069331522 0.562734412303328 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 2/695 23/18639 0.0869565217391304 2.33206130747576 0.210962970047326 0.569179295255892 GO:0016917 GABA receptor activity 2/695 23/18639 0.0869565217391304 2.33206130747576 0.210962970047326 0.569179295255892 GO:0017134 fibroblast growth factor binding 2/695 23/18639 0.0869565217391304 2.33206130747576 0.210962970047326 0.569179295255892 GO:0044013 histone H2B acetyltransferase activity 2/695 23/18639 0.0869565217391304 2.33206130747576 0.210962970047326 0.569179295255892 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 2/695 23/18639 0.0869565217391304 2.33206130747576 0.210962970047326 0.569179295255892 GO:0061775 cohesin loader activity 8/695 153/18639 0.0522875816993464 1.40228523063902 0.212535608398486 0.571793241912973 GO:0008200 ion channel inhibitor activity 3/695 43/18639 0.0697674418604651 1.87107244437009 0.215371911408918 0.573100552755728 GO:0008375 acetylglucosaminyltransferase activity 3/695 43/18639 0.0697674418604651 1.87107244437009 0.215371911408918 0.573100552755728 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 3/695 43/18639 0.0697674418604651 1.87107244437009 0.215371911408918 0.573100552755728 GO:0016887 ATP hydrolysis activity 19/695 417/18639 0.0455635491606715 1.22195538533202 0.215442235249249 0.573100552755728 GO:0043021 ribonucleoprotein complex binding 9/695 177/18639 0.0508474576271186 1.36366296793074 0.216311128438656 0.573800108211224 GO:0042277 peptide binding 12/695 249/18639 0.0481927710843374 1.29246771257693 0.22082316851288 0.574928622644521 GO:0140104 molecular carrier activity 12/695 249/18639 0.0481927710843374 1.29246771257693 0.22082316851288 0.574928622644521 GO:0004386 helicase activity 8/695 155/18639 0.0516129032258065 1.38419122766303 0.222459327112396 0.574928622644521 GO:0061134 peptidase regulator activity 11/695 226/18639 0.0486725663716814 1.30533520086586 0.224247890616738 0.574928622644521 GO:0001091 RNA polymerase II general transcription initiation factor binding 2/695 24/18639 0.0833333333333333 2.23489208633094 0.224830329082885 0.574928622644521 GO:0015295 solute:proton symporter activity 2/695 24/18639 0.0833333333333333 2.23489208633094 0.224830329082885 0.574928622644521 GO:0043998 histone H2A acetyltransferase activity 2/695 24/18639 0.0833333333333333 2.23489208633094 0.224830329082885 0.574928622644521 GO:0048027 mRNA 5'-UTR binding 2/695 24/18639 0.0833333333333333 2.23489208633094 0.224830329082885 0.574928622644521 GO:0050431 transforming growth factor beta binding 2/695 24/18639 0.0833333333333333 2.23489208633094 0.224830329082885 0.574928622644521 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 2/695 24/18639 0.0833333333333333 2.23489208633094 0.224830329082885 0.574928622644521 GO:0070840 dynein complex binding 2/695 24/18639 0.0833333333333333 2.23489208633094 0.224830329082885 0.574928622644521 GO:0001046 core promoter sequence-specific DNA binding 3/695 44/18639 0.0681818181818182 1.8285480706344 0.225236028512267 0.574928622644521 GO:0030020 extracellular matrix structural constituent conferring tensile strength 3/695 44/18639 0.0681818181818182 1.8285480706344 0.225236028512267 0.574928622644521 GO:0043014 alpha-tubulin binding 3/695 44/18639 0.0681818181818182 1.8285480706344 0.225236028512267 0.574928622644521 GO:0005126 cytokine receptor binding 13/695 275/18639 0.0472727272727273 1.26779332897319 0.228443013521422 0.581547133883835 GO:0005543 phospholipid binding 22/695 497/18639 0.0442655935613682 1.18714589696452 0.232743338404051 0.590906009299294 GO:0004715 non-membrane spanning protein tyrosine kinase activity 3/695 45/18639 0.0666666666666667 1.78791366906475 0.235185298917849 0.595509299666319 GO:0003707 nuclear steroid receptor activity 2/695 25/18639 0.08 2.1454964028777 0.238761916295738 0.599068058198025 GO:0008483 transaminase activity 2/695 25/18639 0.08 2.1454964028777 0.238761916295738 0.599068058198025 GO:0120020 cholesterol transfer activity 2/695 25/18639 0.08 2.1454964028777 0.238761916295738 0.599068058198025 GO:0042054 histone methyltransferase activity 4/695 67/18639 0.0597014925373134 1.60111671856545 0.239753742404489 0.599068058198025 GO:0050840 extracellular matrix binding 4/695 67/18639 0.0597014925373134 1.60111671856545 0.239753742404489 0.599068058198025 GO:0019838 growth factor binding 7/695 136/18639 0.0514705882352941 1.38037452391028 0.245091417252515 0.609484797801654 GO:0030276 clathrin binding 3/695 46/18639 0.0652173913043478 1.74904598060682 0.245209828893802 0.609484797801654 GO:0061135 endopeptidase regulator activity 9/695 184/18639 0.0489130434782609 1.31178448545511 0.249400582519858 0.618278407451061 GO:0004435 phosphatidylinositol phospholipase C activity 2/695 26/18639 0.0769230769230769 2.06297731045932 0.252733701334414 0.61844655081057 GO:0050681 nuclear androgen receptor binding 2/695 26/18639 0.0769230769230769 2.06297731045932 0.252733701334414 0.61844655081057 GO:0050750 low-density lipoprotein particle receptor binding 2/695 26/18639 0.0769230769230769 2.06297731045932 0.252733701334414 0.61844655081057 GO:0051139 metal cation:proton antiporter activity 2/695 26/18639 0.0769230769230769 2.06297731045932 0.252733701334414 0.61844655081057 GO:0052742 phosphatidylinositol kinase activity 2/695 26/18639 0.0769230769230769 2.06297731045932 0.252733701334414 0.61844655081057 GO:0043495 protein-membrane adaptor activity 3/695 47/18639 0.0638297872340425 1.71183223633859 0.255299964368269 0.621514309143318 GO:0140938 histone H3 methyltransferase activity 3/695 47/18639 0.0638297872340425 1.71183223633859 0.255299964368269 0.621514309143318 GO:0016279 protein-lysine N-methyltransferase activity 4/695 69/18639 0.0579710144927536 1.55470753831717 0.256104892941157 0.621875214398142 GO:0043178 alcohol binding 5/695 92/18639 0.0543478260869565 1.45753831717235 0.259138676847577 0.627632549807304 GO:0016278 lysine N-methyltransferase activity 4/695 70/18639 0.0571428571428571 1.53249743062693 0.264363672449658 0.636239330273607 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 3/695 48/18639 0.0625 1.6761690647482 0.265446300874615 0.636239330273607 GO:0001671 ATPase activator activity 2/695 27/18639 0.0740740740740741 1.98657074340528 0.266723351762008 0.636239330273607 GO:0008266 poly(U) RNA binding 2/695 27/18639 0.0740740740740741 1.98657074340528 0.266723351762008 0.636239330273607 GO:0008320 protein transmembrane transporter activity 2/695 27/18639 0.0740740740740741 1.98657074340528 0.266723351762008 0.636239330273607 GO:0023026 MHC class II protein complex binding 2/695 27/18639 0.0740740740740741 1.98657074340528 0.266723351762008 0.636239330273607 GO:1990782 protein tyrosine kinase binding 6/695 117/18639 0.0512820512820513 1.37531820697288 0.271361903328018 0.636660459108454 GO:0140299 molecular sensor activity 4/695 71/18639 0.0563380281690141 1.51091295977303 0.272671156680485 0.636660459108454 GO:0015291 secondary active transmembrane transporter activity 13/695 287/18639 0.0452961672473868 1.21478454866769 0.275352077102475 0.636660459108454 GO:0005004 GPI-linked ephrin receptor activity 3/695 49/18639 0.0612244897959184 1.64196153281456 0.275639691905455 0.636660459108454 GO:0005008 hepatocyte growth factor receptor activity 3/695 49/18639 0.0612244897959184 1.64196153281456 0.275639691905455 0.636660459108454 GO:0005009 insulin receptor activity 3/695 49/18639 0.0612244897959184 1.64196153281456 0.275639691905455 0.636660459108454 GO:0005011 macrophage colony-stimulating factor receptor activity 3/695 49/18639 0.0612244897959184 1.64196153281456 0.275639691905455 0.636660459108454 GO:0005018 platelet-derived growth factor alpha-receptor activity 3/695 49/18639 0.0612244897959184 1.64196153281456 0.275639691905455 0.636660459108454 GO:0005020 stem cell factor receptor activity 3/695 49/18639 0.0612244897959184 1.64196153281456 0.275639691905455 0.636660459108454 GO:0008288 boss receptor activity 3/695 49/18639 0.0612244897959184 1.64196153281456 0.275639691905455 0.636660459108454 GO:0036332 placental growth factor receptor activity 3/695 49/18639 0.0612244897959184 1.64196153281456 0.275639691905455 0.636660459108454 GO:0038062 protein tyrosine kinase collagen receptor activity 3/695 49/18639 0.0612244897959184 1.64196153281456 0.275639691905455 0.636660459108454 GO:0060175 brain-derived neurotrophic factor receptor activity 3/695 49/18639 0.0612244897959184 1.64196153281456 0.275639691905455 0.636660459108454 GO:0004867 serine-type endopeptidase inhibitor activity 5/695 95/18639 0.0526315789473684 1.41151079136691 0.280628501666924 0.640560247522615 GO:0008276 protein methyltransferase activity 5/695 95/18639 0.0526315789473684 1.41151079136691 0.280628501666924 0.640560247522615 GO:0036408 histone H3K14 acetyltransferase activity 2/695 28/18639 0.0714285714285714 1.91562178828366 0.280710140149826 0.640560247522615 GO:0051393 alpha-actinin binding 2/695 28/18639 0.0714285714285714 1.91562178828366 0.280710140149826 0.640560247522615 GO:0097718 disordered domain specific binding 2/695 28/18639 0.0714285714285714 1.91562178828366 0.280710140149826 0.640560247522615 GO:0005006 epidermal growth factor receptor activity 3/695 50/18639 0.06 1.60912230215827 0.28587125579914 0.640864541020002 GO:0005007 fibroblast growth factor receptor activity 3/695 50/18639 0.06 1.60912230215827 0.28587125579914 0.640864541020002 GO:0005017 platelet-derived growth factor receptor activity 3/695 50/18639 0.06 1.60912230215827 0.28587125579914 0.640864541020002 GO:0005019 platelet-derived growth factor beta-receptor activity 3/695 50/18639 0.06 1.60912230215827 0.28587125579914 0.640864541020002 GO:0004857 enzyme inhibitor activity 18/695 416/18639 0.0432692307692308 1.16042473713337 0.291698519765367 0.640864541020002 GO:0004629 phospholipase C activity 2/695 29/18639 0.0689655172413793 1.84956586454974 0.294674855722898 0.640864541020002 GO:0010484 histone H3 acetyltransferase activity 2/695 29/18639 0.0689655172413793 1.84956586454974 0.294674855722898 0.640864541020002 GO:0005021 vascular endothelial growth factor receptor activity 3/695 51/18639 0.0588235294117647 1.5775708844689 0.296132381274627 0.640864541020002 GO:0005030 neurotrophin receptor activity 3/695 51/18639 0.0588235294117647 1.5775708844689 0.296132381274627 0.640864541020002 GO:0005272 sodium channel activity 3/695 51/18639 0.0588235294117647 1.5775708844689 0.296132381274627 0.640864541020002 GO:0016597 amino acid binding 3/695 51/18639 0.0588235294117647 1.5775708844689 0.296132381274627 0.640864541020002 GO:0003697 single-stranded DNA binding 6/695 121/18639 0.0495867768595041 1.32985314227956 0.297159658439575 0.640864541020002 GO:0008170 N-methyltransferase activity 5/695 98/18639 0.0510204081632653 1.36830127734547 0.302449892860398 0.640864541020002 GO:0015293 symporter activity 7/695 146/18639 0.0479452054794521 1.28582832364246 0.303123647828847 0.640864541020002 GO:0019003 GDP binding 4/695 75/18639 0.0533333333333333 1.4303309352518 0.306289261729849 0.640864541020002 GO:0005080 protein kinase C binding 3/695 52/18639 0.0576923076923077 1.54723298284449 0.30641473172343 0.640864541020002 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 2/695 30/18639 0.0666666666666667 1.78791366906475 0.308599720347828 0.640864541020002 GO:0016769 transferase activity, transferring nitrogenous groups 2/695 30/18639 0.0666666666666667 1.78791366906475 0.308599720347828 0.640864541020002 GO:0043995 histone H4K5 acetyltransferase activity 2/695 30/18639 0.0666666666666667 1.78791366906475 0.308599720347828 0.640864541020002 GO:0043996 histone H4K8 acetyltransferase activity 2/695 30/18639 0.0666666666666667 1.78791366906475 0.308599720347828 0.640864541020002 GO:0043997 histone H4K12 acetyltransferase activity 2/695 30/18639 0.0666666666666667 1.78791366906475 0.308599720347828 0.640864541020002 GO:0098631 cell adhesion mediator activity 4/695 76/18639 0.0526315789473684 1.41151079136691 0.314766762670654 0.640864541020002 GO:0004382 GDP phosphatase activity 1/695 10/18639 0.1 2.68187050359712 0.316205036428733 0.640864541020002 GO:0004445 inositol-polyphosphate 5-phosphatase activity 1/695 10/18639 0.1 2.68187050359712 0.316205036428733 0.640864541020002 GO:0004955 prostaglandin receptor activity 1/695 10/18639 0.1 2.68187050359712 0.316205036428733 0.640864541020002 GO:0005522 profilin binding 1/695 10/18639 0.1 2.68187050359712 0.316205036428733 0.640864541020002 GO:0008190 eukaryotic initiation factor 4E binding 1/695 10/18639 0.1 2.68187050359712 0.316205036428733 0.640864541020002 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 1/695 10/18639 0.1 2.68187050359712 0.316205036428733 0.640864541020002 GO:0008641 ubiquitin-like modifier activating enzyme activity 1/695 10/18639 0.1 2.68187050359712 0.316205036428733 0.640864541020002 GO:0015187 glycine transmembrane transporter activity 1/695 10/18639 0.1 2.68187050359712 0.316205036428733 0.640864541020002 GO:0015643 toxic substance binding 1/695 10/18639 0.1 2.68187050359712 0.316205036428733 0.640864541020002 GO:0015924 mannosyl-oligosaccharide mannosidase activity 1/695 10/18639 0.1 2.68187050359712 0.316205036428733 0.640864541020002 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 1/695 10/18639 0.1 2.68187050359712 0.316205036428733 0.640864541020002 GO:0016889 DNA endonuclease activity, producing 3'-phosphomonoesters 1/695 10/18639 0.1 2.68187050359712 0.316205036428733 0.640864541020002 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 1/695 10/18639 0.1 2.68187050359712 0.316205036428733 0.640864541020002 GO:0030957 Tat protein binding 1/695 10/18639 0.1 2.68187050359712 0.316205036428733 0.640864541020002 GO:0031419 cobalamin binding 1/695 10/18639 0.1 2.68187050359712 0.316205036428733 0.640864541020002 GO:0031720 haptoglobin binding 1/695 10/18639 0.1 2.68187050359712 0.316205036428733 0.640864541020002 GO:0031996 thioesterase binding 1/695 10/18639 0.1 2.68187050359712 0.316205036428733 0.640864541020002 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 1/695 10/18639 0.1 2.68187050359712 0.316205036428733 0.640864541020002 GO:0042975 peroxisome proliferator activated receptor binding 1/695 10/18639 0.1 2.68187050359712 0.316205036428733 0.640864541020002 GO:0043121 neurotrophin binding 1/695 10/18639 0.1 2.68187050359712 0.316205036428733 0.640864541020002 GO:0043208 glycosphingolipid binding 1/695 10/18639 0.1 2.68187050359712 0.316205036428733 0.640864541020002 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 1/695 10/18639 0.1 2.68187050359712 0.316205036428733 0.640864541020002 GO:0045322 unmethylated CpG binding 1/695 10/18639 0.1 2.68187050359712 0.316205036428733 0.640864541020002 GO:0051880 G-quadruplex DNA binding 1/695 10/18639 0.1 2.68187050359712 0.316205036428733 0.640864541020002 GO:0070513 death domain binding 1/695 10/18639 0.1 2.68187050359712 0.316205036428733 0.640864541020002 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 1/695 10/18639 0.1 2.68187050359712 0.316205036428733 0.640864541020002 GO:0140999 histone H3K4 trimethyltransferase activity 1/695 10/18639 0.1 2.68187050359712 0.316205036428733 0.640864541020002 GO:0141109 transporter activator activity 1/695 10/18639 0.1 2.68187050359712 0.316205036428733 0.640864541020002 GO:1905394 retromer complex binding 1/695 10/18639 0.1 2.68187050359712 0.316205036428733 0.640864541020002 GO:0004864 protein phosphatase inhibitor activity 3/695 53/18639 0.0566037735849057 1.51803990769648 0.316710248360465 0.640864541020002 GO:0038064 collagen receptor activity 3/695 53/18639 0.0566037735849057 1.51803990769648 0.316710248360465 0.640864541020002 GO:0017147 Wnt-protein binding 2/695 31/18639 0.0645161290322581 1.73023903457879 0.32246830866273 0.642339360539178 GO:0070273 phosphatidylinositol-4-phosphate binding 2/695 31/18639 0.0645161290322581 1.73023903457879 0.32246830866273 0.642339360539178 GO:0070325 lipoprotein particle receptor binding 2/695 31/18639 0.0645161290322581 1.73023903457879 0.32246830866273 0.642339360539178 GO:0003724 RNA helicase activity 4/695 77/18639 0.051948051948052 1.39317948238812 0.323264113903198 0.642339360539178 GO:0017069 snRNA binding 3/695 54/18639 0.0555555555555556 1.48992805755396 0.327011152329155 0.642339360539178 GO:0000510 H3-H4 histone complex chaperone activity 7/695 151/18639 0.0463576158940397 1.2432512268331 0.333148020494561 0.642339360539178 GO:0140584 chromatin extrusion motor activity 7/695 151/18639 0.0463576158940397 1.2432512268331 0.333148020494561 0.642339360539178 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 7/695 151/18639 0.0463576158940397 1.2432512268331 0.333148020494561 0.642339360539178 GO:0140849 ATP-dependent H2AZ histone chaperone activity 7/695 151/18639 0.0463576158940397 1.2432512268331 0.333148020494561 0.642339360539178 GO:0022884 macromolecule transmembrane transporter activity 2/695 32/18639 0.0625 1.6761690647482 0.33626547215783 0.642339360539178 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 2/695 32/18639 0.0625 1.6761690647482 0.33626547215783 0.642339360539178 GO:0043425 bHLH transcription factor binding 2/695 32/18639 0.0625 1.6761690647482 0.33626547215783 0.642339360539178 GO:0019783 ubiquitin-like protein peptidase activity 6/695 127/18639 0.047244094488189 1.26702543477029 0.33664942826087 0.642339360539178 GO:0140313 molecular sequestering activity 3/695 55/18639 0.0545454545454545 1.46283845650752 0.33730994585002 0.642339360539178 GO:0015616 DNA translocase activity 7/695 152/18639 0.0460526315789474 1.23507194244604 0.339207063714381 0.642339360539178 GO:0140674 ATP-dependent histone chaperone activity 7/695 152/18639 0.0460526315789474 1.23507194244604 0.339207063714381 0.642339360539178 GO:0004722 protein serine/threonine phosphatase activity 5/695 103/18639 0.0485436893203883 1.30187888524132 0.339327249613455 0.642339360539178 GO:0008186 ATP-dependent activity, acting on RNA 4/695 79/18639 0.0506329113924051 1.35790911574538 0.340300403233764 0.642339360539178 GO:0016835 carbon-oxygen lyase activity 4/695 79/18639 0.0506329113924051 1.35790911574538 0.340300403233764 0.642339360539178 GO:0002162 dystroglycan binding 1/695 11/18639 0.0909090909090909 2.4380640941792 0.341715665001498 0.642339360539178 GO:0004016 adenylate cyclase activity 1/695 11/18639 0.0909090909090909 2.4380640941792 0.341715665001498 0.642339360539178 GO:0004143 ATP-dependent diacylglycerol kinase activity 1/695 11/18639 0.0909090909090909 2.4380640941792 0.341715665001498 0.642339360539178 GO:0004954 prostanoid receptor activity 1/695 11/18639 0.0909090909090909 2.4380640941792 0.341715665001498 0.642339360539178 GO:0005221 intracellularly cyclic nucleotide-activated monoatomic cation channel activity 1/695 11/18639 0.0909090909090909 2.4380640941792 0.341715665001498 0.642339360539178 GO:0008503 benzodiazepine receptor activity 1/695 11/18639 0.0909090909090909 2.4380640941792 0.341715665001498 0.642339360539178 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 1/695 11/18639 0.0909090909090909 2.4380640941792 0.341715665001498 0.642339360539178 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 1/695 11/18639 0.0909090909090909 2.4380640941792 0.341715665001498 0.642339360539178 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 1/695 11/18639 0.0909090909090909 2.4380640941792 0.341715665001498 0.642339360539178 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 1/695 11/18639 0.0909090909090909 2.4380640941792 0.341715665001498 0.642339360539178 GO:0019107 myristoyltransferase activity 1/695 11/18639 0.0909090909090909 2.4380640941792 0.341715665001498 0.642339360539178 GO:0019206 nucleoside kinase activity 1/695 11/18639 0.0909090909090909 2.4380640941792 0.341715665001498 0.642339360539178 GO:0034056 estrogen response element binding 1/695 11/18639 0.0909090909090909 2.4380640941792 0.341715665001498 0.642339360539178 GO:0043855 cyclic nucleotide-activated monoatomic ion channel activity 1/695 11/18639 0.0909090909090909 2.4380640941792 0.341715665001498 0.642339360539178 GO:0070697 activin receptor binding 1/695 11/18639 0.0909090909090909 2.4380640941792 0.341715665001498 0.642339360539178 GO:0099528 G protein-coupled neurotransmitter receptor activity 1/695 11/18639 0.0909090909090909 2.4380640941792 0.341715665001498 0.642339360539178 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 6/695 128/18639 0.046875 1.25712679856115 0.343295568888054 0.642339360539178 GO:0019212 phosphatase inhibitor activity 3/695 56/18639 0.0535714285714286 1.43671634121274 0.347599412496256 0.642339360539178 GO:0019239 deaminase activity 2/695 33/18639 0.0606060606060606 1.62537606278613 0.349977267023861 0.642339360539178 GO:0030296 protein tyrosine kinase activator activity 2/695 33/18639 0.0606060606060606 1.62537606278613 0.349977267023861 0.642339360539178 GO:0140311 protein sequestering activity 2/695 33/18639 0.0606060606060606 1.62537606278613 0.349977267023861 0.642339360539178 GO:0003924 GTPase activity 14/695 331/18639 0.0422960725075529 1.13432589276011 0.352971520977269 0.642339360539178 GO:0000287 magnesium ion binding 10/695 230/18639 0.0434782608695652 1.16603065373788 0.355471224289928 0.642339360539178 GO:0001618 virus receptor activity 4/695 81/18639 0.0493827160493827 1.32438049560352 0.3573631629776 0.642339360539178 GO:0030971 receptor tyrosine kinase binding 4/695 81/18639 0.0493827160493827 1.32438049560352 0.3573631629776 0.642339360539178 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 2/695 34/18639 0.0588235294117647 1.5775708844689 0.363590885593412 0.642339360539178 GO:0016831 carboxy-lyase activity 2/695 34/18639 0.0588235294117647 1.5775708844689 0.363590885593412 0.642339360539178 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 2/695 34/18639 0.0588235294117647 1.5775708844689 0.363590885593412 0.642339360539178 GO:0019825 oxygen binding 2/695 34/18639 0.0588235294117647 1.5775708844689 0.363590885593412 0.642339360539178 GO:0030332 cyclin binding 2/695 34/18639 0.0588235294117647 1.5775708844689 0.363590885593412 0.642339360539178 GO:0140272 exogenous protein binding 4/695 82/18639 0.0487804878048781 1.30822951394982 0.365893977034879 0.642339360539178 GO:0004000 adenosine deaminase activity 1/695 12/18639 0.0833333333333333 2.23489208633094 0.366275876125825 0.642339360539178 GO:0004300 enoyl-CoA hydratase activity 1/695 12/18639 0.0833333333333333 2.23489208633094 0.366275876125825 0.642339360539178 GO:0005025 transforming growth factor beta receptor activity, type I 1/695 12/18639 0.0833333333333333 2.23489208633094 0.366275876125825 0.642339360539178 GO:0005026 transforming growth factor beta receptor activity, type II 1/695 12/18639 0.0833333333333333 2.23489208633094 0.366275876125825 0.642339360539178 GO:0005078 MAP-kinase scaffold activity 1/695 12/18639 0.0833333333333333 2.23489208633094 0.366275876125825 0.642339360539178 GO:0005095 GTPase inhibitor activity 1/695 12/18639 0.0833333333333333 2.23489208633094 0.366275876125825 0.642339360539178 GO:0005165 neurotrophin receptor binding 1/695 12/18639 0.0833333333333333 2.23489208633094 0.366275876125825 0.642339360539178 GO:0005247 voltage-gated chloride channel activity 1/695 12/18639 0.0833333333333333 2.23489208633094 0.366275876125825 0.642339360539178 GO:0005436 sodium:phosphate symporter activity 1/695 12/18639 0.0833333333333333 2.23489208633094 0.366275876125825 0.642339360539178 GO:0008179 adenylate cyclase binding 1/695 12/18639 0.0833333333333333 2.23489208633094 0.366275876125825 0.642339360539178 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 1/695 12/18639 0.0833333333333333 2.23489208633094 0.366275876125825 0.642339360539178 GO:0015132 prostaglandin transmembrane transporter activity 1/695 12/18639 0.0833333333333333 2.23489208633094 0.366275876125825 0.642339360539178 GO:0016361 activin receptor activity, type I 1/695 12/18639 0.0833333333333333 2.23489208633094 0.366275876125825 0.642339360539178 GO:0016362 activin receptor activity, type II 1/695 12/18639 0.0833333333333333 2.23489208633094 0.366275876125825 0.642339360539178 GO:0016840 carbon-nitrogen lyase activity 1/695 12/18639 0.0833333333333333 2.23489208633094 0.366275876125825 0.642339360539178 GO:0017002 activin receptor activity 1/695 12/18639 0.0833333333333333 2.23489208633094 0.366275876125825 0.642339360539178 GO:0017166 vinculin binding 1/695 12/18639 0.0833333333333333 2.23489208633094 0.366275876125825 0.642339360539178 GO:0045295 gamma-catenin binding 1/695 12/18639 0.0833333333333333 2.23489208633094 0.366275876125825 0.642339360539178 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 1/695 12/18639 0.0833333333333333 2.23489208633094 0.366275876125825 0.642339360539178 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 1/695 12/18639 0.0833333333333333 2.23489208633094 0.366275876125825 0.642339360539178 GO:0070410 co-SMAD binding 1/695 12/18639 0.0833333333333333 2.23489208633094 0.366275876125825 0.642339360539178 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 1/695 12/18639 0.0833333333333333 2.23489208633094 0.366275876125825 0.642339360539178 GO:0005179 hormone activity 6/695 132/18639 0.0454545454545455 1.2190320470896 0.369986691168318 0.647647683061732 GO:0140658 ATP-dependent chromatin remodeler activity 7/695 158/18639 0.0443037974683544 1.18817047627721 0.375804419485428 0.649881090626012 GO:0004843 cysteine-type deubiquitinase activity 5/695 108/18639 0.0462962962962963 1.2416067146283 0.376517159948266 0.649881090626012 GO:0005154 epidermal growth factor receptor binding 2/695 35/18639 0.0571428571428571 1.53249743062693 0.377094591208235 0.649881090626012 GO:0005343 organic acid:sodium symporter activity 2/695 35/18639 0.0571428571428571 1.53249743062693 0.377094591208235 0.649881090626012 GO:0010485 histone H4 acetyltransferase activity 2/695 35/18639 0.0571428571428571 1.53249743062693 0.377094591208235 0.649881090626012 GO:0016229 steroid dehydrogenase activity 2/695 35/18639 0.0571428571428571 1.53249743062693 0.377094591208235 0.649881090626012 GO:0004518 nuclease activity 9/695 209/18639 0.0430622009569378 1.15487246566383 0.377826875132468 0.649881090626012 GO:0004879 nuclear receptor activity 3/695 59/18639 0.0508474576271186 1.36366296793074 0.378343891314801 0.649881090626012 GO:0036002 pre-mRNA binding 3/695 59/18639 0.0508474576271186 1.36366296793074 0.378343891314801 0.649881090626012 GO:0004860 protein kinase inhibitor activity 4/695 84/18639 0.0476190476190476 1.27708119218911 0.382934395108356 0.649881090626012 GO:0003730 mRNA 3'-UTR binding 11/695 262/18639 0.0419847328244275 1.12597616563238 0.387311890086443 0.649881090626012 GO:0003689 DNA clamp loader activity 7/695 160/18639 0.04375 1.17331834532374 0.388058258638773 0.649881090626012 GO:0098531 ligand-modulated transcription factor activity 3/695 60/18639 0.05 1.34093525179856 0.388529480376227 0.649881090626012 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 1/695 13/18639 0.0769230769230769 2.06297731045932 0.389921029188183 0.649881090626012 GO:0005542 folic acid binding 1/695 13/18639 0.0769230769230769 2.06297731045932 0.389921029188183 0.649881090626012 GO:0008417 fucosyltransferase activity 1/695 13/18639 0.0769230769230769 2.06297731045932 0.389921029188183 0.649881090626012 GO:0015651 quaternary ammonium group transmembrane transporter activity 1/695 13/18639 0.0769230769230769 2.06297731045932 0.389921029188183 0.649881090626012 GO:0031994 insulin-like growth factor I binding 1/695 13/18639 0.0769230769230769 2.06297731045932 0.389921029188183 0.649881090626012 GO:0043560 insulin receptor substrate binding 1/695 13/18639 0.0769230769230769 2.06297731045932 0.389921029188183 0.649881090626012 GO:0045159 myosin II binding 1/695 13/18639 0.0769230769230769 2.06297731045932 0.389921029188183 0.649881090626012 GO:0046974 histone H3K9 methyltransferase activity 1/695 13/18639 0.0769230769230769 2.06297731045932 0.389921029188183 0.649881090626012 GO:0051011 microtubule minus-end binding 1/695 13/18639 0.0769230769230769 2.06297731045932 0.389921029188183 0.649881090626012 GO:0061459 L-arginine transmembrane transporter activity 1/695 13/18639 0.0769230769230769 2.06297731045932 0.389921029188183 0.649881090626012 GO:0070700 BMP receptor binding 1/695 13/18639 0.0769230769230769 2.06297731045932 0.389921029188183 0.649881090626012 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 1/695 13/18639 0.0769230769230769 2.06297731045932 0.389921029188183 0.649881090626012 GO:0089720 caspase binding 1/695 13/18639 0.0769230769230769 2.06297731045932 0.389921029188183 0.649881090626012 GO:0140852 histone ubiquitin ligase activity 1/695 13/18639 0.0769230769230769 2.06297731045932 0.389921029188183 0.649881090626012 GO:0004190 aspartic-type endopeptidase activity 2/695 36/18639 0.0555555555555556 1.48992805755396 0.390477656352905 0.649881090626012 GO:0015026 coreceptor activity 3/695 61/18639 0.0491803278688525 1.31895270668711 0.398673838664045 0.651354759809901 GO:1902936 phosphatidylinositol bisphosphate binding 5/695 111/18639 0.045045045045045 1.2080497763951 0.398834990089221 0.651354759809901 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 4/695 86/18639 0.0465116279069767 1.24738162958006 0.399921006710596 0.651354759809901 GO:0050660 flavin adenine dinucleotide binding 4/695 86/18639 0.0465116279069767 1.24738162958006 0.399921006710596 0.651354759809901 GO:0008083 growth factor activity 7/695 162/18639 0.0432098765432099 1.15883293365308 0.400318955257941 0.651354759809901 GO:0140597 protein carrier chaperone 8/695 188/18639 0.0425531914893617 1.14122149089239 0.402769601121828 0.651354759809901 GO:0042805 actinin binding 2/695 37/18639 0.0540540540540541 1.44965973167412 0.403730303902343 0.651354759809901 GO:0070001 aspartic-type peptidase activity 2/695 37/18639 0.0540540540540541 1.44965973167412 0.403730303902343 0.651354759809901 GO:0005200 structural constituent of cytoskeleton 5/695 112/18639 0.0446428571428571 1.19726361767729 0.406259080033677 0.651354759809901 GO:0008081 phosphoric diester hydrolase activity 4/695 87/18639 0.0459770114942529 1.23304390969983 0.408384970528815 0.651354759809901 GO:0016741 transferase activity, transferring one-carbon groups 9/695 215/18639 0.0418604651162791 1.12264346662205 0.409806450072925 0.651354759809901 GO:0140713 histone chaperone activity 7/695 164/18639 0.0426829268292683 1.14470082470609 0.41257461769871 0.651354759809901 GO:0004705 JUN kinase activity 1/695 14/18639 0.0714285714285714 1.91562178828366 0.412685169890117 0.651354759809901 GO:0005161 platelet-derived growth factor receptor binding 1/695 14/18639 0.0714285714285714 1.91562178828366 0.412685169890117 0.651354759809901 GO:0005344 oxygen carrier activity 1/695 14/18639 0.0714285714285714 1.91562178828366 0.412685169890117 0.651354759809901 GO:0008195 phosphatidate phosphatase activity 1/695 14/18639 0.0714285714285714 1.91562178828366 0.412685169890117 0.651354759809901 GO:0008474 palmitoyl-(protein) hydrolase activity 1/695 14/18639 0.0714285714285714 1.91562178828366 0.412685169890117 0.651354759809901 GO:0008494 translation activator activity 1/695 14/18639 0.0714285714285714 1.91562178828366 0.412685169890117 0.651354759809901 GO:0015386 potassium:proton antiporter activity 1/695 14/18639 0.0714285714285714 1.91562178828366 0.412685169890117 0.651354759809901 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 1/695 14/18639 0.0714285714285714 1.91562178828366 0.412685169890117 0.651354759809901 GO:0034236 protein kinase A catalytic subunit binding 1/695 14/18639 0.0714285714285714 1.91562178828366 0.412685169890117 0.651354759809901 GO:0042813 Wnt receptor activity 1/695 14/18639 0.0714285714285714 1.91562178828366 0.412685169890117 0.651354759809901 GO:0043176 amine binding 1/695 14/18639 0.0714285714285714 1.91562178828366 0.412685169890117 0.651354759809901 GO:0044548 S100 protein binding 1/695 14/18639 0.0714285714285714 1.91562178828366 0.412685169890117 0.651354759809901 GO:0061665 SUMO ligase activity 1/695 14/18639 0.0714285714285714 1.91562178828366 0.412685169890117 0.651354759809901 GO:0070742 C2H2 zinc finger domain binding 1/695 14/18639 0.0714285714285714 1.91562178828366 0.412685169890117 0.651354759809901 GO:0071933 Arp2/3 complex binding 1/695 14/18639 0.0714285714285714 1.91562178828366 0.412685169890117 0.651354759809901 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 1/695 14/18639 0.0714285714285714 1.91562178828366 0.412685169890117 0.651354759809901 GO:0098599 palmitoyl hydrolase activity 1/695 14/18639 0.0714285714285714 1.91562178828366 0.412685169890117 0.651354759809901 GO:0098821 BMP receptor activity 1/695 14/18639 0.0714285714285714 1.91562178828366 0.412685169890117 0.651354759809901 GO:1901474 azole transmembrane transporter activity 1/695 14/18639 0.0714285714285714 1.91562178828366 0.412685169890117 0.651354759809901 GO:0070851 growth factor receptor binding 6/695 139/18639 0.0431654676258993 1.15764194399876 0.41679594102514 0.653561155325589 GO:0004197 cysteine-type endopeptidase activity 4/695 88/18639 0.0454545454545455 1.2190320470896 0.416824705318592 0.653561155325589 GO:0005109 frizzled binding 2/695 38/18639 0.0526315789473684 1.41151079136691 0.416843651337546 0.653561155325589 GO:0043531 ADP binding 2/695 38/18639 0.0526315789473684 1.41151079136691 0.416843651337546 0.653561155325589 GO:0005507 copper ion binding 3/695 63/18639 0.0476190476190476 1.27708119218911 0.418816878886991 0.654487762881155 GO:1901682 sulfur compound transmembrane transporter activity 3/695 63/18639 0.0476190476190476 1.27708119218911 0.418816878886991 0.654487762881155 GO:0008514 organic anion transmembrane transporter activity 11/695 269/18639 0.0408921933085502 1.09667567061592 0.420801799215852 0.65650626665142 GO:0101005 deubiquitinase activity 5/695 115/18639 0.0434782608695652 1.16603065373788 0.428451105295915 0.661683636335261 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 7/695 167/18639 0.0419161676646707 1.12413733683712 0.430923420419875 0.661683636335261 GO:0019210 kinase inhibitor activity 4/695 90/18639 0.0444444444444444 1.19194244604317 0.433618150176905 0.661683636335261 GO:0004089 carbonate dehydratase activity 1/695 15/18639 0.0666666666666667 1.78791366906475 0.434601078986834 0.661683636335261 GO:0004559 alpha-mannosidase activity 1/695 15/18639 0.0666666666666667 1.78791366906475 0.434601078986834 0.661683636335261 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 1/695 15/18639 0.0666666666666667 1.78791366906475 0.434601078986834 0.661683636335261 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 1/695 15/18639 0.0666666666666667 1.78791366906475 0.434601078986834 0.661683636335261 GO:0004865 protein serine/threonine phosphatase inhibitor activity 1/695 15/18639 0.0666666666666667 1.78791366906475 0.434601078986834 0.661683636335261 GO:0004953 icosanoid receptor activity 1/695 15/18639 0.0666666666666667 1.78791366906475 0.434601078986834 0.661683636335261 GO:0005523 tropomyosin binding 1/695 15/18639 0.0666666666666667 1.78791366906475 0.434601078986834 0.661683636335261 GO:0017081 chloride channel regulator activity 1/695 15/18639 0.0666666666666667 1.78791366906475 0.434601078986834 0.661683636335261 GO:0030553 cGMP binding 1/695 15/18639 0.0666666666666667 1.78791366906475 0.434601078986834 0.661683636335261 GO:0047372 monoacylglycerol lipase activity 1/695 15/18639 0.0666666666666667 1.78791366906475 0.434601078986834 0.661683636335261 GO:0048531 beta-1,3-galactosyltransferase activity 1/695 15/18639 0.0666666666666667 1.78791366906475 0.434601078986834 0.661683636335261 GO:0140776 protein-containing complex destabilizing activity 1/695 15/18639 0.0666666666666667 1.78791366906475 0.434601078986834 0.661683636335261 GO:0015294 solute:monoatomic cation symporter activity 5/695 116/18639 0.0431034482758621 1.15597866534359 0.435813818213419 0.662464985309965 GO:0120013 lipid transfer activity 3/695 65/18639 0.0461538461538462 1.23778638627559 0.438731665626105 0.665831550237054 GO:0022804 active transmembrane transporter activity 18/695 457/18639 0.0393873085339169 1.05631660973191 0.439923726953889 0.666572431080533 GO:0015144 carbohydrate transmembrane transporter activity 2/695 40/18639 0.05 1.34093525179856 0.442621073784176 0.667455663811489 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 2/695 40/18639 0.05 1.34093525179856 0.442621073784176 0.667455663811489 GO:0050997 quaternary ammonium group binding 2/695 40/18639 0.05 1.34093525179856 0.442621073784176 0.667455663811489 GO:0015175 neutral L-amino acid transmembrane transporter activity 2/695 41/18639 0.0487804878048781 1.30822951394982 0.455271393544175 0.671148059566757 GO:0140828 metal cation:monoatomic cation antiporter activity 2/695 41/18639 0.0487804878048781 1.30822951394982 0.455271393544175 0.671148059566757 GO:0000062 fatty-acyl-CoA binding 1/695 16/18639 0.0625 1.6761690647482 0.45570031922009 0.671148059566757 GO:0004707 MAP kinase activity 1/695 16/18639 0.0625 1.6761690647482 0.45570031922009 0.671148059566757 GO:0004708 MAP kinase kinase activity 1/695 16/18639 0.0625 1.6761690647482 0.45570031922009 0.671148059566757 GO:0005159 insulin-like growth factor receptor binding 1/695 16/18639 0.0625 1.6761690647482 0.45570031922009 0.671148059566757 GO:0005521 lamin binding 1/695 16/18639 0.0625 1.6761690647482 0.45570031922009 0.671148059566757 GO:0008142 oxysterol binding 1/695 16/18639 0.0625 1.6761690647482 0.45570031922009 0.671148059566757 GO:0015562 efflux transmembrane transporter activity 1/695 16/18639 0.0625 1.6761690647482 0.45570031922009 0.671148059566757 GO:0015923 mannosidase activity 1/695 16/18639 0.0625 1.6761690647482 0.45570031922009 0.671148059566757 GO:0016722 oxidoreductase activity, acting on metal ions 1/695 16/18639 0.0625 1.6761690647482 0.45570031922009 0.671148059566757 GO:0022858 alanine transmembrane transporter activity 1/695 16/18639 0.0625 1.6761690647482 0.45570031922009 0.671148059566757 GO:0043023 ribosomal large subunit binding 1/695 16/18639 0.0625 1.6761690647482 0.45570031922009 0.671148059566757 GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 1/695 16/18639 0.0625 1.6761690647482 0.45570031922009 0.671148059566757 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 1/695 16/18639 0.0625 1.6761690647482 0.45570031922009 0.671148059566757 GO:0016500 protein-hormone receptor activity 3/695 67/18639 0.0447761194029851 1.20083753892408 0.458380943913929 0.674047754482129 GO:0004402 histone acetyltransferase activity 2/695 42/18639 0.0476190476190476 1.27708119218911 0.467754809754808 0.679916405196087 GO:0004520 DNA endonuclease activity 2/695 42/18639 0.0476190476190476 1.27708119218911 0.467754809754808 0.679916405196087 GO:0030145 manganese ion binding 3/695 68/18639 0.0441176470588235 1.18317816335167 0.468095454665404 0.679916405196087 GO:1990841 promoter-specific chromatin binding 3/695 68/18639 0.0441176470588235 1.18317816335167 0.468095454665404 0.679916405196087 GO:0016829 lyase activity 8/695 200/18639 0.04 1.07274820143885 0.470735525458475 0.679916405196087 GO:0003823 antigen binding 7/695 174/18639 0.0402298850574713 1.07891342098735 0.473383827495637 0.679916405196087 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 1/695 17/18639 0.0588235294117647 1.5775708844689 0.47601328051215 0.679916405196087 GO:0004659 prenyltransferase activity 1/695 17/18639 0.0588235294117647 1.5775708844689 0.47601328051215 0.679916405196087 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 1/695 17/18639 0.0588235294117647 1.5775708844689 0.47601328051215 0.679916405196087 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 1/695 17/18639 0.0588235294117647 1.5775708844689 0.47601328051215 0.679916405196087 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 1/695 17/18639 0.0588235294117647 1.5775708844689 0.47601328051215 0.679916405196087 GO:0015278 intracellularly gated calcium channel activity 1/695 17/18639 0.0588235294117647 1.5775708844689 0.47601328051215 0.679916405196087 GO:0015347 sodium-independent organic anion transmembrane transporter activity 1/695 17/18639 0.0588235294117647 1.5775708844689 0.47601328051215 0.679916405196087 GO:0017110 nucleoside diphosphate phosphatase activity 1/695 17/18639 0.0588235294117647 1.5775708844689 0.47601328051215 0.679916405196087 GO:0019198 transmembrane receptor protein phosphatase activity 1/695 17/18639 0.0588235294117647 1.5775708844689 0.47601328051215 0.679916405196087 GO:0031489 myosin V binding 1/695 17/18639 0.0588235294117647 1.5775708844689 0.47601328051215 0.679916405196087 GO:0032183 SUMO binding 1/695 17/18639 0.0588235294117647 1.5775708844689 0.47601328051215 0.679916405196087 GO:0051787 misfolded protein binding 1/695 17/18639 0.0588235294117647 1.5775708844689 0.47601328051215 0.679916405196087 GO:1901567 fatty acid derivative binding 1/695 17/18639 0.0588235294117647 1.5775708844689 0.47601328051215 0.679916405196087 GO:0002039 p53 binding 3/695 69/18639 0.0434782608695652 1.16603065373788 0.477731389289234 0.681342809724254 GO:0016407 acetyltransferase activity 4/695 96/18639 0.0416666666666667 1.11744604316547 0.483090203013793 0.687949507148966 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 9/695 229/18639 0.0393013100436681 1.05401024158839 0.484061332576307 0.688297420344989 GO:0016790 thiolester hydrolase activity 2/695 44/18639 0.0454545454545455 1.2190320470896 0.492200939322941 0.691169447187747 GO:0019205 nucleobase-containing compound kinase activity 2/695 44/18639 0.0454545454545455 1.2190320470896 0.492200939322941 0.691169447187747 GO:0008168 methyltransferase activity 8/695 204/18639 0.0392156862745098 1.05171392297926 0.493060450144916 0.691169447187747 GO:0000400 four-way junction DNA binding 1/695 18/18639 0.0555555555555556 1.48992805755396 0.495569223485196 0.691169447187747 GO:0003746 translation elongation factor activity 1/695 18/18639 0.0555555555555556 1.48992805755396 0.495569223485196 0.691169447187747 GO:0008308 voltage-gated monoatomic anion channel activity 1/695 18/18639 0.0555555555555556 1.48992805755396 0.495569223485196 0.691169447187747 GO:0008409 5'-3' exonuclease activity 1/695 18/18639 0.0555555555555556 1.48992805755396 0.495569223485196 0.691169447187747 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 1/695 18/18639 0.0555555555555556 1.48992805755396 0.495569223485196 0.691169447187747 GO:0017128 phospholipid scramblase activity 1/695 18/18639 0.0555555555555556 1.48992805755396 0.495569223485196 0.691169447187747 GO:0031690 adrenergic receptor binding 1/695 18/18639 0.0555555555555556 1.48992805755396 0.495569223485196 0.691169447187747 GO:0070064 proline-rich region binding 1/695 18/18639 0.0555555555555556 1.48992805755396 0.495569223485196 0.691169447187747 GO:0070628 proteasome binding 1/695 18/18639 0.0555555555555556 1.48992805755396 0.495569223485196 0.691169447187747 GO:0098641 cadherin binding involved in cell-cell adhesion 1/695 18/18639 0.0555555555555556 1.48992805755396 0.495569223485196 0.691169447187747 GO:0042626 ATPase-coupled transmembrane transporter activity 4/695 98/18639 0.0408163265306122 1.09464102187638 0.49920469679742 0.695215952745818 GO:0140303 intramembrane lipid transporter activity 2/695 45/18639 0.0444444444444444 1.19194244604317 0.504155155155737 0.701079195201883 GO:0005518 collagen binding 3/695 72/18639 0.0416666666666667 1.11744604316547 0.506133045195435 0.702797644868148 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 1/695 19/18639 0.0526315789473684 1.41151079136691 0.514396321368112 0.703949879097691 GO:0005520 insulin-like growth factor binding 1/695 19/18639 0.0526315789473684 1.41151079136691 0.514396321368112 0.703949879097691 GO:0008574 plus-end-directed microtubule motor activity 1/695 19/18639 0.0526315789473684 1.41151079136691 0.514396321368112 0.703949879097691 GO:0022821 solute:potassium antiporter activity 1/695 19/18639 0.0526315789473684 1.41151079136691 0.514396321368112 0.703949879097691 GO:0042800 histone H3K4 methyltransferase activity 1/695 19/18639 0.0526315789473684 1.41151079136691 0.514396321368112 0.703949879097691 GO:0043395 heparan sulfate proteoglycan binding 1/695 19/18639 0.0526315789473684 1.41151079136691 0.514396321368112 0.703949879097691 GO:0046624 sphingolipid transporter activity 1/695 19/18639 0.0526315789473684 1.41151079136691 0.514396321368112 0.703949879097691 GO:0050145 nucleoside monophosphate kinase activity 1/695 19/18639 0.0526315789473684 1.41151079136691 0.514396321368112 0.703949879097691 GO:0097001 ceramide binding 1/695 19/18639 0.0526315789473684 1.41151079136691 0.514396321368112 0.703949879097691 GO:0120227 acyl-CoA binding 1/695 19/18639 0.0526315789473684 1.41151079136691 0.514396321368112 0.703949879097691 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 2/695 46/18639 0.0434782608695652 1.16603065373788 0.515925397258552 0.705023594810748 GO:0003678 DNA helicase activity 3/695 74/18639 0.0405405405405405 1.08724479875559 0.524614802721889 0.715864867691108 GO:0008094 ATP-dependent activity, acting on DNA 8/695 210/18639 0.0380952380952381 1.02166495375128 0.526020792104443 0.715881814806883 GO:0061733 protein-lysine-acetyltransferase activity 2/695 47/18639 0.0425531914893617 1.14122149089239 0.527508749831453 0.715881814806883 GO:0099095 ligand-gated monoatomic anion channel activity 2/695 47/18639 0.0425531914893617 1.14122149089239 0.527508749831453 0.715881814806883 GO:0019001 guanyl nucleotide binding 15/695 400/18639 0.0375 1.00570143884892 0.528406957286178 0.715881814806883 GO:0032561 guanyl ribonucleotide binding 15/695 400/18639 0.0375 1.00570143884892 0.528406957286178 0.715881814806883 GO:0015171 amino acid transmembrane transporter activity 4/695 102/18639 0.0392156862745098 1.05171392297926 0.530755354687898 0.7180361726992 GO:0016505 peptidase activator activity involved in apoptotic process 1/695 20/18639 0.05 1.34093525179856 0.532521700350344 0.718373290928456 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 1/695 20/18639 0.05 1.34093525179856 0.532521700350344 0.718373290928456 GO:0005253 monoatomic anion channel activity 4/695 103/18639 0.0388349514563107 1.04150310819306 0.538489823579794 0.721537208396893 GO:0032266 phosphatidylinositol-3-phosphate binding 2/695 48/18639 0.0416666666666667 1.11744604316547 0.538902769351316 0.721537208396893 GO:0036121 double-stranded DNA helicase activity 2/695 48/18639 0.0416666666666667 1.11744604316547 0.538902769351316 0.721537208396893 GO:0016757 glycosyltransferase activity 10/695 267/18639 0.0374531835205993 1.00444588149705 0.539657192237527 0.721537208396893 GO:0005262 calcium channel activity 5/695 131/18639 0.0381679389312977 1.02361469602944 0.54260511813654 0.721537208396893 GO:0005525 GTP binding 14/695 378/18639 0.037037037037037 0.993285371702638 0.548908057518355 0.721537208396893 GO:0031406 carboxylic acid binding 7/695 187/18639 0.0374331550802139 1.00390874466202 0.549710194798994 0.721537208396893 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 1/695 21/18639 0.0476190476190476 1.27708119218911 0.54997147844028 0.721537208396893 GO:0005123 death receptor binding 1/695 21/18639 0.0476190476190476 1.27708119218911 0.54997147844028 0.721537208396893 GO:0008373 sialyltransferase activity 1/695 21/18639 0.0476190476190476 1.27708119218911 0.54997147844028 0.721537208396893 GO:0009931 calcium-dependent protein serine/threonine kinase activity 1/695 21/18639 0.0476190476190476 1.27708119218911 0.54997147844028 0.721537208396893 GO:0009975 cyclase activity 1/695 21/18639 0.0476190476190476 1.27708119218911 0.54997147844028 0.721537208396893 GO:0010314 phosphatidylinositol-5-phosphate binding 1/695 21/18639 0.0476190476190476 1.27708119218911 0.54997147844028 0.721537208396893 GO:0015174 basic amino acid transmembrane transporter activity 1/695 21/18639 0.0476190476190476 1.27708119218911 0.54997147844028 0.721537208396893 GO:0036122 BMP binding 1/695 21/18639 0.0476190476190476 1.27708119218911 0.54997147844028 0.721537208396893 GO:0070182 DNA polymerase binding 1/695 21/18639 0.0476190476190476 1.27708119218911 0.54997147844028 0.721537208396893 GO:0140312 cargo adaptor activity 1/695 21/18639 0.0476190476190476 1.27708119218911 0.54997147844028 0.721537208396893 GO:1904047 S-adenosyl-L-methionine binding 1/695 21/18639 0.0476190476190476 1.27708119218911 0.54997147844028 0.721537208396893 GO:0016763 pentosyltransferase activity 2/695 49/18639 0.0408163265306122 1.09464102187638 0.550105453497948 0.721537208396893 GO:0060590 ATPase regulator activity 2/695 49/18639 0.0408163265306122 1.09464102187638 0.550105453497948 0.721537208396893 GO:0005178 integrin binding 6/695 161/18639 0.0372670807453416 0.999454846061039 0.558598592181424 0.731663716176775 GO:0043177 organic acid binding 7/695 189/18639 0.037037037037037 0.993285371702638 0.561044225030388 0.732932559328859 GO:0032813 tumor necrosis factor receptor superfamily binding 2/695 50/18639 0.04 1.07274820143885 0.561115211735399 0.732932559328859 GO:0015370 solute:sodium symporter activity 3/695 79/18639 0.0379746835443038 1.01843183680903 0.569087135979292 0.742321649824227 GO:0016830 carbon-carbon lyase activity 2/695 51/18639 0.0392156862745098 1.05171392297926 0.571930837468491 0.745004818545613 GO:0015081 sodium ion transmembrane transporter activity 6/695 164/18639 0.0365853658536585 0.981172135462362 0.576739624159881 0.750236846262922 GO:0005283 amino acid:sodium symporter activity 1/695 23/18639 0.0434782608695652 1.16603065373788 0.582943886194243 0.752108801397749 GO:0016849 phosphorus-oxygen lyase activity 1/695 23/18639 0.0434782608695652 1.16603065373788 0.582943886194243 0.752108801397749 GO:0031681 G-protein beta-subunit binding 1/695 23/18639 0.0434782608695652 1.16603065373788 0.582943886194243 0.752108801397749 GO:0043274 phospholipase binding 1/695 23/18639 0.0434782608695652 1.16603065373788 0.582943886194243 0.752108801397749 GO:0070577 lysine-acetylated histone binding 1/695 23/18639 0.0434782608695652 1.16603065373788 0.582943886194243 0.752108801397749 GO:0099186 structural constituent of postsynapse 1/695 23/18639 0.0434782608695652 1.16603065373788 0.582943886194243 0.752108801397749 GO:0140098 catalytic activity, acting on RNA 14/695 387/18639 0.0361757105943152 0.9701857118956 0.584679460969364 0.753321700051684 GO:0017046 peptide hormone binding 2/695 53/18639 0.0377358490566038 1.01202660513099 0.592976628103699 0.760634018371799 GO:0034212 protein N-acetyltransferase activity 2/695 53/18639 0.0377358490566038 1.01202660513099 0.592976628103699 0.760634018371799 GO:0140296 general transcription initiation factor binding 2/695 53/18639 0.0377358490566038 1.01202660513099 0.592976628103699 0.760634018371799 GO:0140767 enzyme-substrate adaptor activity 5/695 139/18639 0.0359712230215827 0.964701619998965 0.595538113683823 0.760634018371799 GO:0004622 lysophospholipase activity 1/695 24/18639 0.0416666666666667 1.11744604316547 0.598514040851258 0.760634018371799 GO:0005315 phosphate transmembrane transporter activity 1/695 24/18639 0.0416666666666667 1.11744604316547 0.598514040851258 0.760634018371799 GO:0030552 cAMP binding 1/695 24/18639 0.0416666666666667 1.11744604316547 0.598514040851258 0.760634018371799 GO:0035035 histone acetyltransferase binding 1/695 24/18639 0.0416666666666667 1.11744604316547 0.598514040851258 0.760634018371799 GO:0140033 acetylation-dependent protein binding 1/695 24/18639 0.0416666666666667 1.11744604316547 0.598514040851258 0.760634018371799 GO:0140612 DNA damage sensor activity 1/695 24/18639 0.0416666666666667 1.11744604316547 0.598514040851258 0.760634018371799 GO:0140097 catalytic activity, acting on DNA 12/695 336/18639 0.0357142857142857 0.957810894141829 0.601994679657309 0.760634018371799 GO:0005254 chloride channel activity 3/695 83/18639 0.036144578313253 0.969350784432695 0.602758936911561 0.760634018371799 GO:0008135 translation factor activity, RNA binding 3/695 83/18639 0.036144578313253 0.969350784432695 0.602758936911561 0.760634018371799 GO:0003925 G protein activity 2/695 54/18639 0.037037037037037 0.993285371702638 0.603206069479642 0.760634018371799 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 2/695 54/18639 0.037037037037037 0.993285371702638 0.603206069479642 0.760634018371799 GO:0050661 NADP binding 2/695 54/18639 0.037037037037037 0.993285371702638 0.603206069479642 0.760634018371799 GO:0016758 hexosyltransferase activity 7/695 197/18639 0.0355329949238579 0.952948909907607 0.605026239438099 0.761914692483883 GO:0180051 translation factor activity 3/695 84/18639 0.0357142857142857 0.957810894141829 0.610900586607976 0.763453371792678 GO:0098632 cell-cell adhesion mediator activity 2/695 55/18639 0.0363636363636364 0.975225637671681 0.613239885465666 0.763453371792678 GO:0001848 complement binding 1/695 25/18639 0.04 1.07274820143885 0.613503712707738 0.763453371792678 GO:0004709 MAP kinase kinase kinase activity 1/695 25/18639 0.04 1.07274820143885 0.613503712707738 0.763453371792678 GO:0005251 delayed rectifier potassium channel activity 1/695 25/18639 0.04 1.07274820143885 0.613503712707738 0.763453371792678 GO:0005537 D-mannose binding 1/695 25/18639 0.04 1.07274820143885 0.613503712707738 0.763453371792678 GO:0015271 outward rectifier potassium channel activity 1/695 25/18639 0.04 1.07274820143885 0.613503712707738 0.763453371792678 GO:0017056 structural constituent of nuclear pore 1/695 25/18639 0.04 1.07274820143885 0.613503712707738 0.763453371792678 GO:0047617 fatty acyl-CoA hydrolase activity 1/695 25/18639 0.04 1.07274820143885 0.613503712707738 0.763453371792678 GO:0016209 antioxidant activity 3/695 86/18639 0.0348837209302326 0.935536222185043 0.626845747634585 0.770277181301878 GO:0005112 Notch binding 1/695 26/18639 0.0384615384615385 1.03148865522966 0.627934513162671 0.770277181301878 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 1/695 26/18639 0.0384615384615385 1.03148865522966 0.627934513162671 0.770277181301878 GO:0008157 protein phosphatase 1 binding 1/695 26/18639 0.0384615384615385 1.03148865522966 0.627934513162671 0.770277181301878 GO:0015145 monosaccharide transmembrane transporter activity 1/695 26/18639 0.0384615384615385 1.03148865522966 0.627934513162671 0.770277181301878 GO:0016289 acyl-CoA hydrolase activity 1/695 26/18639 0.0384615384615385 1.03148865522966 0.627934513162671 0.770277181301878 GO:0030247 polysaccharide binding 1/695 26/18639 0.0384615384615385 1.03148865522966 0.627934513162671 0.770277181301878 GO:0034237 protein kinase A regulatory subunit binding 1/695 26/18639 0.0384615384615385 1.03148865522966 0.627934513162671 0.770277181301878 GO:0043548 phosphatidylinositol 3-kinase binding 1/695 26/18639 0.0384615384615385 1.03148865522966 0.627934513162671 0.770277181301878 GO:0070006 metalloaminopeptidase activity 1/695 26/18639 0.0384615384615385 1.03148865522966 0.627934513162671 0.770277181301878 GO:0070412 R-SMAD binding 1/695 26/18639 0.0384615384615385 1.03148865522966 0.627934513162671 0.770277181301878 GO:0004601 peroxidase activity 2/695 57/18639 0.0350877192982456 0.941007194244604 0.632722268949834 0.77336650296952 GO:0016504 peptidase activator activity 2/695 57/18639 0.0350877192982456 0.941007194244604 0.632722268949834 0.77336650296952 GO:0008194 UDP-glycosyltransferase activity 5/695 145/18639 0.0344827586206897 0.92478293227487 0.632902893137675 0.77336650296952 GO:0004364 glutathione transferase activity 1/695 27/18639 0.037037037037037 0.993285371702638 0.641827250139619 0.775685098561097 GO:0004683 calcium/calmodulin-dependent protein kinase activity 1/695 27/18639 0.037037037037037 0.993285371702638 0.641827250139619 0.775685098561097 GO:0005104 fibroblast growth factor receptor binding 1/695 27/18639 0.037037037037037 0.993285371702638 0.641827250139619 0.775685098561097 GO:0005385 zinc ion transmembrane transporter activity 1/695 27/18639 0.037037037037037 0.993285371702638 0.641827250139619 0.775685098561097 GO:0008395 steroid hydroxylase activity 1/695 27/18639 0.037037037037037 0.993285371702638 0.641827250139619 0.775685098561097 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 1/695 27/18639 0.037037037037037 0.993285371702638 0.641827250139619 0.775685098561097 GO:0035255 ionotropic glutamate receptor binding 1/695 27/18639 0.037037037037037 0.993285371702638 0.641827250139619 0.775685098561097 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 1/695 27/18639 0.037037037037037 0.993285371702638 0.641827250139619 0.775685098561097 GO:0017116 single-stranded DNA helicase activity 2/695 58/18639 0.0344827586206897 0.92478293227487 0.642172246327244 0.775685098561097 GO:0015085 calcium ion transmembrane transporter activity 5/695 147/18639 0.0340136054421769 0.912200851563647 0.644878619861351 0.777961850966496 GO:0001786 phosphatidylserine binding 2/695 59/18639 0.0338983050847458 0.90910864528716 0.651429381590839 0.781456239480374 GO:0070888 E-box binding 2/695 59/18639 0.0338983050847458 0.90910864528716 0.651429381590839 0.781456239480374 GO:0016866 intramolecular transferase activity 1/695 28/18639 0.0357142857142857 0.957810894141829 0.655201957917019 0.781456239480374 GO:0019789 SUMO transferase activity 1/695 28/18639 0.0357142857142857 0.957810894141829 0.655201957917019 0.781456239480374 GO:0046625 sphingolipid binding 1/695 28/18639 0.0357142857142857 0.957810894141829 0.655201957917019 0.781456239480374 GO:0046875 ephrin receptor binding 1/695 28/18639 0.0357142857142857 0.957810894141829 0.655201957917019 0.781456239480374 GO:0051019 mitogen-activated protein kinase binding 1/695 28/18639 0.0357142857142857 0.957810894141829 0.655201957917019 0.781456239480374 GO:0051119 sugar transmembrane transporter activity 1/695 28/18639 0.0357142857142857 0.957810894141829 0.655201957917019 0.781456239480374 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 1/695 28/18639 0.0357142857142857 0.957810894141829 0.655201957917019 0.781456239480374 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 2/695 60/18639 0.0333333333333333 0.893956834532374 0.660494895425825 0.785789781367157 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 2/695 60/18639 0.0333333333333333 0.893956834532374 0.660494895425825 0.785789781367157 GO:0072341 modified amino acid binding 3/695 91/18639 0.032967032967033 0.884133133053996 0.664710566088061 0.788865082022868 GO:0005416 amino acid:monoatomic cation symporter activity 1/695 29/18639 0.0344827586206897 0.92478293227487 0.668077925852524 0.788865082022868 GO:0043236 laminin binding 1/695 29/18639 0.0344827586206897 0.92478293227487 0.668077925852524 0.788865082022868 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 1/695 29/18639 0.0344827586206897 0.92478293227487 0.668077925852524 0.788865082022868 GO:0051861 glycolipid binding 1/695 29/18639 0.0344827586206897 0.92478293227487 0.668077925852524 0.788865082022868 GO:0099604 ligand-gated calcium channel activity 1/695 29/18639 0.0344827586206897 0.92478293227487 0.668077925852524 0.788865082022868 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 2/695 61/18639 0.0327868852459016 0.879301804458073 0.669370185485547 0.789406682010975 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 4/695 122/18639 0.0327868852459016 0.879301804458073 0.671638581480376 0.791096687390443 GO:0046906 tetrapyrrole binding 5/695 152/18639 0.0328947368421053 0.882194244604317 0.67372777290522 0.792571678187879 GO:0051213 dioxygenase activity 3/695 93/18639 0.032258064516129 0.865119517289394 0.679051789881187 0.79458522634044 GO:0015215 nucleotide transmembrane transporter activity 1/695 30/18639 0.0333333333333333 0.893956834532374 0.680473726042341 0.79458522634044 GO:0031210 phosphatidylcholine binding 1/695 30/18639 0.0333333333333333 0.893956834532374 0.680473726042341 0.79458522634044 GO:0031624 ubiquitin conjugating enzyme binding 1/695 30/18639 0.0333333333333333 0.893956834532374 0.680473726042341 0.79458522634044 GO:0035925 mRNA 3'-UTR AU-rich region binding 1/695 30/18639 0.0333333333333333 0.893956834532374 0.680473726042341 0.79458522634044 GO:0098918 structural constituent of synapse 1/695 30/18639 0.0333333333333333 0.893956834532374 0.680473726042341 0.79458522634044 GO:0042562 hormone binding 3/695 94/18639 0.0319148936170213 0.855916118169294 0.686049965263933 0.798733400419528 GO:0022824 transmitter-gated monoatomic ion channel activity 2/695 63/18639 0.0317460317460317 0.851387461459404 0.686556481458813 0.798733400419528 GO:0022835 transmitter-gated channel activity 2/695 63/18639 0.0317460317460317 0.851387461459404 0.686556481458813 0.798733400419528 GO:0005164 tumor necrosis factor receptor binding 1/695 31/18639 0.032258064516129 0.865119517289394 0.692407239954995 0.802582198576964 GO:0008327 methyl-CpG binding 1/695 31/18639 0.032258064516129 0.865119517289394 0.692407239954995 0.802582198576964 GO:0072349 modified amino acid transmembrane transporter activity 1/695 31/18639 0.032258064516129 0.865119517289394 0.692407239954995 0.802582198576964 GO:0004536 DNA nuclease activity 2/695 64/18639 0.03125 0.838084532374101 0.694871038071563 0.804453390041284 GO:0008234 cysteine-type peptidase activity 6/695 187/18639 0.0320855614973262 0.860493209710307 0.701899971332503 0.811598623750769 GO:0031369 translation initiation factor binding 1/695 32/18639 0.03125 0.838084532374101 0.703895684077484 0.812913674172411 GO:0001217 DNA-binding transcription repressor activity 9/695 278/18639 0.0323741007194245 0.868231457999068 0.713374201152755 0.822676775183545 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 1/695 33/18639 0.0303030303030303 0.812688031393067 0.71495563461041 0.822676775183545 GO:0042923 neuropeptide binding 1/695 33/18639 0.0303030303030303 0.812688031393067 0.71495563461041 0.822676775183545 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 2/695 67/18639 0.0298507462686567 0.800558359282723 0.718724224832263 0.82540940572051 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 4/695 130/18639 0.0307692307692308 0.82519092418373 0.719073663906463 0.82540940572051 GO:0008175 tRNA methyltransferase activity 1/695 34/18639 0.0294117647058824 0.788785442234448 0.725603051247288 0.829886581559398 GO:0015035 protein-disulfide reductase activity 1/695 34/18639 0.0294117647058824 0.788785442234448 0.725603051247288 0.829886581559398 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 1/695 34/18639 0.0294117647058824 0.788785442234448 0.725603051247288 0.829886581559398 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 4/695 132/18639 0.0303030303030303 0.812688031393067 0.730107684875845 0.83403133604032 GO:0008080 N-acetyltransferase activity 2/695 69/18639 0.0289855072463768 0.777353769158586 0.733739562818401 0.837170320468706 GO:0015103 inorganic anion transmembrane transporter activity 5/695 165/18639 0.0303030303030303 0.812688031393067 0.741228329215603 0.844697024990584 GO:0044390 ubiquitin-like protein conjugating enzyme binding 1/695 36/18639 0.0277777777777778 0.744964028776978 0.745721175606797 0.846113928082811 GO:0045505 dynein intermediate chain binding 1/695 36/18639 0.0277777777777778 0.744964028776978 0.745721175606797 0.846113928082811 GO:0015399 primary active transmembrane transporter activity 5/695 166/18639 0.0301204819277108 0.807792320360579 0.745967582657136 0.846113928082811 GO:0015297 antiporter activity 4/695 135/18639 0.0296296296296296 0.79462829736211 0.746045543768899 0.846113928082811 GO:0016874 ligase activity 5/695 167/18639 0.029940119760479 0.802955240597941 0.750642464147784 0.850309107114775 GO:0030551 cyclic nucleotide binding 1/695 37/18639 0.027027027027027 0.72482986583706 0.755220922043031 0.853453715005669 GO:0043394 proteoglycan binding 1/695 37/18639 0.027027027027027 0.72482986583706 0.755220922043031 0.853453715005669 GO:0004497 monooxygenase activity 3/695 106/18639 0.0283018867924528 0.759019953848242 0.76122505210767 0.857736567601526 GO:0004521 RNA endonuclease activity 2/695 73/18639 0.0273972602739726 0.734759042081403 0.761728039443383 0.857736567601526 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 2/695 73/18639 0.0273972602739726 0.734759042081403 0.761728039443383 0.857736567601526 GO:0003684 damaged DNA binding 2/695 74/18639 0.027027027027027 0.72482986583706 0.768314518241202 0.864125711133513 GO:0000217 DNA secondary structure binding 1/695 39/18639 0.0256410256410256 0.687659103486442 0.773170374628283 0.867526474849507 GO:0016776 phosphotransferase activity, phosphate group as acceptor 1/695 39/18639 0.0256410256410256 0.687659103486442 0.773170374628283 0.867526474849507 GO:0004620 phospholipase activity 3/695 109/18639 0.0275229357798165 0.738129496402878 0.777565027579258 0.871424948068116 GO:0020037 heme binding 4/695 142/18639 0.028169014084507 0.755456479886513 0.780423382142279 0.871871330797794 GO:0004177 aminopeptidase activity 1/695 40/18639 0.025 0.670467625899281 0.78164599772685 0.871871330797794 GO:0015036 disulfide oxidoreductase activity 1/695 40/18639 0.025 0.670467625899281 0.78164599772685 0.871871330797794 GO:0140662 ATP-dependent protein folding chaperone 1/695 40/18639 0.025 0.670467625899281 0.78164599772685 0.871871330797794 GO:0004222 metalloendopeptidase activity 3/695 110/18639 0.0272727272727273 0.731419228253761 0.782803506352458 0.872135200606797 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 8/695 268/18639 0.0298507462686567 0.800558359282723 0.786221403751113 0.874913830026209 GO:0019955 cytokine binding 4/695 144/18639 0.0277777777777778 0.744964028776978 0.789540100762388 0.875814611945377 GO:0001530 lipopolysaccharide binding 1/695 41/18639 0.024390243902439 0.654114756974908 0.789805362831417 0.875814611945377 GO:0042287 MHC protein binding 1/695 41/18639 0.024390243902439 0.654114756974908 0.789805362831417 0.875814611945377 GO:0046873 metal ion transmembrane transporter activity 14/695 450/18639 0.0311111111111111 0.834359712230216 0.792377858179103 0.877639569234632 GO:0008307 structural constituent of muscle 1/695 42/18639 0.0238095238095238 0.638540596094553 0.797660254369871 0.881428542460056 GO:0042056 chemoattractant activity 1/695 42/18639 0.0238095238095238 0.638540596094553 0.797660254369871 0.881428542460056 GO:0000049 tRNA binding 2/695 80/18639 0.025 0.670467625899281 0.80458874237754 0.887712748893792 GO:0005245 voltage-gated calcium channel activity 1/695 43/18639 0.0232558139534884 0.623690814790028 0.805222018267969 0.887712748893792 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 5/695 181/18639 0.0276243093922652 0.74084820541357 0.809475268781349 0.891364045972021 GO:0008509 monoatomic anion transmembrane transporter activity 4/695 149/18639 0.0268456375838926 0.719965235864999 0.811008244777127 0.892014875498187 GO:0042605 peptide antigen binding 1/695 45/18639 0.0222222222222222 0.595971223021583 0.819509451495428 0.898235475192327 GO:0046915 transition metal ion transmembrane transporter activity 1/695 45/18639 0.0222222222222222 0.595971223021583 0.819509451495428 0.898235475192327 GO:0051539 4 iron, 4 sulfur cluster binding 1/695 45/18639 0.0222222222222222 0.595971223021583 0.819509451495428 0.898235475192327 GO:0001540 amyloid-beta binding 2/695 83/18639 0.0240963855421687 0.646233856288463 0.820762474814414 0.898568859710116 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 1/695 46/18639 0.0217391304347826 0.58301532686894 0.826255763811803 0.903163203307831 GO:0003774 cytoskeletal motor activity 4/695 153/18639 0.0261437908496732 0.701142615319509 0.826866417389535 0.903163203307831 GO:0005504 fatty acid binding 1/695 47/18639 0.0212765957446809 0.570610745446196 0.832750264115724 0.906453448411023 GO:0061749 forked DNA-dependent helicase activity 1/695 47/18639 0.0212765957446809 0.570610745446196 0.832750264115724 0.906453448411023 GO:1990518 single-stranded 3'-5' DNA helicase activity 1/695 47/18639 0.0212765957446809 0.570610745446196 0.832750264115724 0.906453448411023 GO:0015108 chloride transmembrane transporter activity 3/695 121/18639 0.0247933884297521 0.664926571139782 0.8339410740691 0.906707459406932 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 3/695 122/18639 0.0245901639344262 0.659476353343555 0.838032733546126 0.907003669558648 GO:0009378 four-way junction helicase activity 1/695 48/18639 0.0208333333333333 0.558723021582734 0.839002338472414 0.907003669558648 GO:0016879 ligase activity, forming carbon-nitrogen bonds 1/695 48/18639 0.0208333333333333 0.558723021582734 0.839002338472414 0.907003669558648 GO:0038187 pattern recognition receptor activity 1/695 48/18639 0.0208333333333333 0.558723021582734 0.839002338472414 0.907003669558648 GO:0043138 3'-5' DNA helicase activity 1/695 48/18639 0.0208333333333333 0.558723021582734 0.839002338472414 0.907003669558648 GO:0035254 glutamate receptor binding 1/695 49/18639 0.0204081632653061 0.547320510938188 0.845021023576048 0.911475857104241 GO:0016651 oxidoreductase activity, acting on NAD(P)H 2/695 88/18639 0.0227272727272727 0.609516023544801 0.845064205425051 0.911475857104241 GO:0015605 organophosphate ester transmembrane transporter activity 1/695 50/18639 0.02 0.536374100719424 0.850815019736061 0.916634611706542 GO:0003743 translation initiation factor activity 1/695 51/18639 0.0196078431372549 0.525856961489632 0.856392703381413 0.920381521878133 GO:0030544 Hsp70 protein binding 1/695 51/18639 0.0196078431372549 0.525856961489632 0.856392703381413 0.920381521878133 GO:0004519 endonuclease activity 3/695 127/18639 0.0236220472440945 0.633512717385147 0.857208555751335 0.920381521878133 GO:0052689 carboxylic ester hydrolase activity 2/695 92/18639 0.0217391304347826 0.58301532686894 0.862308669258771 0.924808957857369 GO:0005246 calcium channel regulator activity 1/695 53/18639 0.0188679245283019 0.506013302565495 0.866931091235247 0.925389442657374 GO:0005544 calcium-dependent phospholipid binding 1/695 53/18639 0.0188679245283019 0.506013302565495 0.866931091235247 0.925389442657374 GO:1901505 carbohydrate derivative transmembrane transporter activity 1/695 53/18639 0.0188679245283019 0.506013302565495 0.866931091235247 0.925389442657374 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 1/695 53/18639 0.0188679245283019 0.506013302565495 0.866931091235247 0.925389442657374 GO:0016298 lipase activity 3/695 130/18639 0.0230769230769231 0.618893193137797 0.867735823737855 0.925389442657374 GO:0016410 N-acyltransferase activity 2/695 94/18639 0.0212765957446809 0.570610745446196 0.870255560975213 0.926878724940596 GO:0031072 heat shock protein binding 3/695 131/18639 0.0229007633587786 0.614168817617662 0.871089825973738 0.926878724940596 GO:0004896 cytokine receptor activity 2/695 96/18639 0.0208333333333333 0.558723021582734 0.877778861503669 0.932947903304124 GO:0051087 protein-folding chaperone binding 3/695 134/18639 0.0223880597014925 0.600418769462042 0.880704977715577 0.933640019041713 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 1/695 56/18639 0.0178571428571429 0.478905447070915 0.881308417367699 0.933640019041713 GO:0030594 neurotransmitter receptor activity 2/695 97/18639 0.0206185567010309 0.552962990432396 0.881387726529347 0.933640019041713 GO:0005249 voltage-gated potassium channel activity 2/695 98/18639 0.0204081632653061 0.547320510938188 0.88489789898063 0.936163884574209 GO:0015932 nucleobase-containing compound transmembrane transporter activity 1/695 57/18639 0.0175438596491228 0.470503597122302 0.885747455732303 0.936163884574209 GO:0004175 endopeptidase activity 11/695 405/18639 0.0271604938271605 0.728409272581934 0.893475338290068 0.943278868852502 GO:0033218 amide binding 6/695 247/18639 0.0242914979757085 0.651466519092418 0.90236607903543 0.95160431720106 GO:0019843 rRNA binding 1/695 65/18639 0.0153846153846154 0.412595462091865 0.915782788793351 0.961436425313292 GO:0038024 cargo receptor activity 1/695 65/18639 0.0153846153846154 0.412595462091865 0.915782788793351 0.961436425313292 GO:0160215 deacylase activity 1/695 65/18639 0.0153846153846154 0.412595462091865 0.915782788793351 0.961436425313292 GO:0008237 metallopeptidase activity 4/695 184/18639 0.0217391304347826 0.58301532686894 0.915822650434201 0.961436425313292 GO:0015078 proton transmembrane transporter activity 4/695 185/18639 0.0216216216216216 0.579863892669648 0.917849730048681 0.961436425313292 GO:0008235 metalloexopeptidase activity 1/695 66/18639 0.0151515151515152 0.406344015696534 0.918934019642313 0.961436425313292 GO:0015276 ligand-gated monoatomic ion channel activity 4/695 186/18639 0.021505376344086 0.576746344859596 0.919833069022368 0.961436425313292 GO:0019842 vitamin binding 3/695 150/18639 0.02 0.536374100719424 0.921950343323372 0.961436425313292 GO:0008173 RNA methyltransferase activity 1/695 67/18639 0.0149253731343284 0.400279179641362 0.92196750138186 0.961436425313292 GO:0022834 ligand-gated channel activity 4/695 188/18639 0.0212765957446809 0.570610745446196 0.923671589114299 0.961436425313292 GO:0003777 microtubule motor activity 1/695 68/18639 0.0147058823529412 0.394392721117224 0.924887627730105 0.961436425313292 GO:0005548 phospholipid transporter activity 1/695 68/18639 0.0147058823529412 0.394392721117224 0.924887627730105 0.961436425313292 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 1/695 68/18639 0.0147058823529412 0.394392721117224 0.924887627730105 0.961436425313292 GO:0098960 postsynaptic neurotransmitter receptor activity 1/695 69/18639 0.0144927536231884 0.388676884579293 0.927698628684689 0.963301097987281 GO:0140375 immune receptor activity 3/695 156/18639 0.0192307692307692 0.515744327614831 0.93371620625426 0.968487675052337 GO:0046982 protein heterodimerization activity 9/695 369/18639 0.024390243902439 0.654114756974908 0.935729271034695 0.969513807078617 GO:0048029 monosaccharide binding 1/695 74/18639 0.0135135135135135 0.36241493291853 0.940254090929258 0.972461635253844 GO:0015079 potassium ion transmembrane transporter activity 3/695 160/18639 0.01875 0.50285071942446 0.940628149833708 0.972461635253844 GO:0044183 protein folding chaperone 1/695 75/18639 0.0133333333333333 0.35758273381295 0.942490740905243 0.973074846277302 GO:0051082 unfolded protein binding 2/695 121/18639 0.0165289256198347 0.443284380759855 0.943276355736603 0.973074846277302 GO:0051536 iron-sulfur cluster binding 1/695 76/18639 0.0131578947368421 0.352877697841727 0.944643775545992 0.973425087532159 GO:0051540 metal cluster binding 1/695 77/18639 0.012987012987013 0.348294870597029 0.946716316406604 0.974500382214189 GO:0005267 potassium channel activity 2/695 124/18639 0.0161290322580645 0.432559758644697 0.948384869757135 0.974660512470237 GO:0005216 monoatomic ion channel activity 11/695 448/18639 0.0245535714285714 0.658494989722508 0.948930298307876 0.974660512470237 GO:0033293 monocarboxylic acid binding 1/695 79/18639 0.0126582278481013 0.339477278936345 0.950631825475085 0.975134061703194 GO:0030246 carbohydrate binding 6/695 280/18639 0.0214285714285714 0.574686536485098 0.952105145593428 0.975134061703194 GO:0048306 calcium-dependent protein binding 1/695 80/18639 0.0125 0.33523381294964 0.952480472096573 0.975134061703194 GO:0005244 voltage-gated monoatomic ion channel activity 3/695 173/18639 0.0173410404624277 0.465064249178692 0.958743837352713 0.980486408178206 GO:0022832 voltage-gated channel activity 3/695 175/18639 0.0171428571428571 0.459749229188078 0.961021271478435 0.981755279493072 GO:0099094 ligand-gated monoatomic cation channel activity 2/695 136/18639 0.0147058823529412 0.394392721117224 0.964757124380402 0.984509694814915 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 1/695 91/18639 0.010989010989011 0.294711044351332 0.968776071270301 0.987546759411168 GO:0022843 voltage-gated monoatomic cation channel activity 2/695 143/18639 0.013986013986014 0.375086783719877 0.971866655518798 0.989388070890896 GO:0005261 monoatomic cation channel activity 7/695 341/18639 0.0205278592375367 0.550530601911433 0.972671904962433 0.989388070890896 GO:0008238 exopeptidase activity 1/695 102/18639 0.00980392156862745 0.262928480744816 0.979488723455253 0.994987749808481 GO:0022836 gated channel activity 6/695 318/18639 0.0188679245283019 0.506013302565495 0.980278321617014 0.994987749808481 GO:0009055 electron transfer activity 1/695 116/18639 0.00862068965517241 0.231195733068717 0.987989342223911 0.999953589063376 GO:0008528 G protein-coupled peptide receptor activity 1/695 122/18639 0.00819672131147541 0.219825451114518 0.990452253674146 0.999953589063376 GO:0004252 serine-type endopeptidase activity 2/695 176/18639 0.0113636363636364 0.3047580117724 0.990490352750361 0.999953589063376 GO:0001653 peptide receptor activity 1/695 128/18639 0.0078125 0.209521133093525 0.992410694658972 0.999953589063376 GO:0016798 hydrolase activity, acting on glycosyl bonds 1/695 130/18639 0.00769230769230769 0.206297731045932 0.992969895878425 0.999953589063376 GO:0008236 serine-type peptidase activity 2/695 194/18639 0.0103092783505155 0.276481495216198 0.994804670532212 0.999953589063376 GO:0140101 catalytic activity, acting on a tRNA 1/695 139/18639 0.00719424460431655 0.192940323999793 0.995018785718465 0.999953589063376 GO:0017171 serine hydrolase activity 2/695 198/18639 0.0101010101010101 0.270896010464356 0.995462521322553 0.999953589063376 GO:0001664 G protein-coupled receptor binding 4/695 297/18639 0.0134680134680135 0.361194680619141 0.996069750971755 0.999953589063376 GO:0005506 iron ion binding 1/695 154/18639 0.00649350649350649 0.174147435298514 0.997195905135825 0.999953589063376 GO:0005125 cytokine activity 2/695 234/18639 0.00854700854700855 0.229219701162147 0.998677929482074 0.999953589063376 GO:0016853 isomerase activity 1/695 180/18639 0.00555555555555556 0.148992805755396 0.998965422707793 0.999953589063376 GO:0045182 translation regulator activity 4/695 356/18639 0.0112359550561798 0.301333764449115 0.999333096422015 0.999953589063376 GO:0030371 translation repressor activity 2/695 329/18639 0.0060790273556231 0.163031641556056 0.999953589063376 0.999953589063376