category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	25/755	93/9376	3.33831802321441	NECTIN3/EGFR/TJP1/CTNNA1/HEG1/CTNNA2/WASL/RAP1B/ARHGAP29/SMURF1/PDCD10/EP300/ACTN4/CDH5/SMURF2/PTPRM/INSR/TGFBR1/CREBBP/MAP3K7/IQGAP1/CDH1/FER/ERBB2/AFDN	6.70627205578087
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	43/755	250/9376	2.13598940397351	CYTH3/EGFR/PIP5K1B/ARAP2/ARPC5/NEDD4/DNAJC6/SPART/WASL/PIP5K1A/PARD6B/VPS37A/SMURF1/PSD4/NEDD4L/KIF5B/PDCD6IP/CHMP2B/EEA1/SMURF2/RAB11FIP2/ARFGAP1/MDM2/WASHC1/SH3GLB1/SPG21/IST1/TGFBR1/RUFY2/RAB22A/ARAP3/SMAD2/HLA-B/AP2A2/SH3KBP1/RAB5B/CLTC/RAB5A/PIP5K1C/RABEP1/CAPZA1/GRK2/GIT1	5.38746354002204
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	32/755	169/9376	2.35144010345233	DAPK1/ATG9B/WDFY3/RRAS2/STX7/GABARAPL1/AKT3/BIRC6/TAX1BP1/BCL2/ULK1/MAPK8/AKT1/IRS2/SUPT20H/ATG10/C9orf72/RHEB/EPG5/CTSL/SH3GLB1/WDR45B/ATG2B/MAP3K7/PIK3C3/ATG14/ATG5/AMBRA1/MAP1LC3A/PTEN/STK11/MAP1LC3B	5.24639970006467
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	20/755	83/9376	2.99242001117051	LCOR/ASXL3/AEBP2/PHC3/SUZ12/RYBP/EP300/MBD5/TEX10/RNF2/PHC2/MBD6/PCGF3/SCMH1/UBE2D3/SCML1/CREBBP/MTF2/FBRSL1/USP7	5.39538281184841
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	38/755	232/9376	2.03407170586892	EGFR/PIP5K1B/DIAPH2/RRAS2/ARPC5/VAV3/NCKAP1/PDGFD/DOCK1/AKT3/TIAM1/IQGAP2/PPP1R12B/PPP1CB/WASL/ARHGEF12/PIP5K1A/SCIN/RDX/PTK2/AKT1/PIKFYVE/PAK2/ITGB1/ITGB4/DIAPH1/MYLK/ACTN4/PDGFB/TMSB4X/PAK1/SSH2/IQGAP1/PPP1R12A/GNG12/PIP5K1C/GNA13/GIT1	4.71961780004527
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	27/755	142/9376	2.36127226937786	UBE2H/UBR5/UBA6/NEDD4/UBE2E2/UBE3A/BIRC6/PIAS1/UBE2E3/UBE2R2/CUL3/HERC4/FBXW11/SMURF1/NEDD4L/COP1/SMURF2/CUL5/MDM2/KEAP1/RBX1/UBE2M/HERC1/UBE2D3/TRIP12/UBE2G1/FBXW8	4.83698261102894
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	34/755	203/9376	2.07995302254265	EGFR/PIP5K1B/VAV3/PDGFD/DOCK1/AKT3/PPP1R12B/PPP1CB/FLT4/RAP1B/GSK3B/PIP5K1A/BCL2/ARHGAP5/PTK2/MAPK8/AKT1/PAK2/ITGB1/LAMC1/ITGB4/DIAPH1/ELK1/SPP1/MYLK/ACTN4/PDGFB/COL1A1/PAK1/PPP1R12A/RAPGEF1/ERBB2/PIP5K1C/PTEN	4.60338690491931
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	21/755	105/9376	2.48370860927152	ATG9B/RRAS2/GABARAPL1/USP15/TAX1BP1/AMFR/ULK1/MAPK8/SMURF1/ATF4/SMURF2/BCL2L13/OPA1/ARIH1/TBC1D15/RHOT1/AMBRA1/RAB5B/RAB5A/MAP1LC3A/MAP1LC3B	4.52439243098258
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	19/755	90/9376	2.62169242089772	PRKAG2/ADCY7/AKT3/SESN3/SESN1/CREB3L2/ULK1/AKT1/IRS2/CREB5/ATF4/RHEB/PPARG/ADCY3/INSR/EHMT1/ATG5/ATF2/STK11	4.57462704868954
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	29/755	170/9376	2.11845734320218	PRKAG2/ARPC5/TJP1/CLDN1/ARHGAP17/NEDD4/TIAM1/PARD6B/RDX/DLG1/MAPK8/RAPGEF2/PRKCE/ITGB1/NEDD4L/CLDN16/YBX3/ACTN4/CGNL1/AMOTL1/CLDN4/OCLN/PPP2R2A/SYMPK/MPDZ/ERBB2/AFDN/MAP2K7/STK11	4.35500534222988
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	28/755	174/9376	1.9983862373449	STT3B/NFE2L2/BCAP29/BCL2/RAD23B/AMFR/MAPK8/SEC24B/SEC61A1/MAN1A2/CANX/ATF4/LMAN1/HSP90AA1/ATF6/RBX1/EDEM1/UBE2D3/NPLOC4/UBQLN4/GANAB/DNAJC10/SEC63/UBE2G1/MAP2K7/SEL1L/PDIA3/SEC13	3.93380100383563
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	21/755	122/9376	2.13761806535664	CSHL1/PLCB1/CSH2/CSH1/ADCY7/AKT3/GSK3B/MAP2K4/CREB3L2/PTK2/MAPK8/AKT1/IRS2/CREB5/EP300/ATF4/ADCY3/CREBBP/GNAI1/GH2/ATF2	3.74275965406591
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	16/755	86/9376	2.31042661327584	EGFR/AKT3/GSK3B/GAB1/MAP2K4/PTK2/MAPK8/AKT1/PAK2/ELK1/CDKN1A/ABL2/NCK2/PAK1/ERBB2/MAP2K7	3.61272050979209
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	10/755	42/9376	2.95679596341848	PCBP2/ACSL4/NCOA4/SLC40A1/FTH1/GCLM/SLC39A8/ATG5/MAP1LC3A/MAP1LC3B	3.76111473646273
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	18/755	104/9376	2.1493632195619	AGPAT5/DGKI/GDPD5/PISD/SGMS2/CEPT1/CDS1/GPCPD1/ETNK1/LPIN2/CHKA/SGMS1/LPGAT1/GNPAT/PLPP1/LPCAT1/LPIN1/CRLS1	3.48792826948522
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	21/755	130/9376	2.00607233825777	PLCB1/EGFR/ADCY7/AKT3/GNGT1/MAP2K4/CREB3L2/MAPK8/AKT1/CREB5/GNB1/ATF4/COL3A1/ADCY3/TGFBR1/COL1A1/GNAI1/SMAD2/ATF2/GNG12/MAP2K7	3.41825321860777
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	22/755	140/9376	1.9514853358562	PLCB1/PRKAG2/RRAS2/ADCY7/AKT3/GNGT1/NRF1/AKT1/PRKCE/GNB1/SPP1/MYLK/ADCY3/TGFBR1/GNAI1/PIK3C3/SMAD2/CDH1/GNG12/GNA13/MAP1LC3A/MAP1LC3B	3.35663753419088
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	39/755	300/9376	1.61441059602649	RASA1/EGFR/RRAS2/PDGFD/MAP4K3/AKT3/FLT4/RAP1B/MAP2K4/JUND/RPS6KA6/STK3/PPP3CB/MAPK8/AKT1/RAPGEF2/PAK2/MAP3K12/DUSP16/NF1/ELK1/TAB2/ATF4/MKNK1/ARTN/MAP2K5/INSR/PDGFB/PPM1A/TGFBR1/MAP3K7/ELK4/PAK1/TAOK1/PPP3CC/ERBB2/ATF2/GNG12/MAP2K7	3.20075455407008
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	22/755	142/9376	1.92399962690048	AKT3/NFE2L2/BCL2/MAP2K4/PTK2/MAPK8/NCF2/AKT1/GSTA4/GPC1/ACVR2B/CDH5/HSP90AA1/MAP2K5/GSTA3/CTSL/PDGFB/KEAP1/SUMO3/ACVR1/MAP3K7/MAP2K7	3.28323012850138
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	45/755	362/9376	1.54374153891186	CSHL1/CSH2/EGFR/CSH1/PDGFD/AKT3/CSF3R/GNGT1/FLT4/GSK3B/PRLR/BCL2/CREB3L2/PTK2/YWHAZ/AKT1/CREB5/ITGB1/LAMC1/GNB1/ITGB4/SPP1/CDKN1A/IL7/ATF4/RHEB/HSP90AA1/ARTN/MDM2/INSR/PDGFB/PPP2R2A/PHLPP1/COL1A1/PPP2R5E/PPP2R3A/RXRA/GH2/ERBB2/ATF2/GNG12/PTEN/PKN2/MAGI2/STK11	3.12225458391349
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	17/755	99/9376	2.13247708876848	EGFR/PIP5K1B/PDGFD/DGKI/AKT3/PIP5K1A/SLC44A1/MAPK8/AKT1/GPCPD1/CHKA/RHEB/SLC22A5/PDGFB/PLPP1/SLC44A5/PIP5K1C	3.35215070281171
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	18/755	109/9376	2.05076857646273	PRKAG2/AKT3/PPP1CB/SLC27A6/GSK3B/CREB3L2/RPS6KA6/MAPK8/AKT1/IRS2/CREB5/PRKCE/TBC1D4/INSR/OGA/CPT1B/GFPT2/PTEN	3.26535975268508
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	33/755	248/9376	1.65246742149113	CYTH3/NAIP/ARPC5/TAB3/NCKAP1/AKT3/WASL/ELMO1/BCL2/MAP2K4/KPNA4/MAPK8/AKT1/KPNA1/KIF5B/AHNAK/TAB2/PIK3C2B/ARL8B/DYNC1LI1/HSP90AA1/DYNC1I1/MAP3K7/PIK3C3/PAK1/ABI1/KLC1/RAB5B/EXOC5/RAB5A/EXOC4/MAP2K7/ARL8A	3.08160626134833
NA	NA	hsa04517	IgSF CAM signaling	38/755	299/9376	1.57827637378458	RASA1/NECTIN3/NRCAM/GRIP1/ARPC5/MTSS1/VAV3/ANK3/TJP1/NLGN4Y/CABLES1/AKT3/WASL/RAP1B/GSK3B/PARD6B/EPB41L2/RDX/PTK2/MAPK8/AKT1/RAPGEF2/PAK2/ITGB1/TRIO/SRGAP2/MYLK/ACTN4/NCK2/MPDZ/PAK1/IQGAP1/CDH1/AFDN/EPB41L3/SPTAN1/MAGI2/GIT1	3.0073236310897
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	21/755	138/9376	1.88977828966312	PIP5K1B/ARPC5/VAV3/DOCK1/AKT3/WASL/ARHGEF12/GSK3B/PIP5K1A/ELMO1/MAP2K4/PTK2/RPS6KA6/MAPK8/AKT1/ITGB1/TAB2/MAP3K7/PIP5K1C/MAP2K7/PKN2	3.11610914288355
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	14/755	78/9376	2.22896926473085	PLCB1/PIP5K1B/PIP5K1A/INPPL1/INPP5F/MINPP1/PIKFYVE/PPIP5K2/PIK3C2B/PIK3C3/SYNJ1/MTM1/PIP5K1C/PTEN	3.22532767931027
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	28/755	204/9376	1.70450590832359	EGFR/RRAS2/VAV3/ANK3/AKT3/TIAM1/FRS2/PPP1R12B/PPP1CB/ARHGEF12/GAB1/TWIST1/RDX/CD44/PTK2/AKT1/ITGB1/GPC1/ELK1/CDKN1A/CTSL/MDM2/COL1A1/PAK1/SMAD2/IQGAP1/PPP1R12A/ERBB2	3.01056488546348
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	19/755	122/9376	1.93403539246553	PRKAG2/AKT3/CREB3L2/ULK1/AKT1/IRS2/CREB5/TBC1D1/RHEB/PPARG/INSR/PPP2R2A/CPT1B/MAP3K7/PPP2R5E/RAB14/PPP2R3A/EEF2/STK11	3.07297333687617
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	11/755	56/9376	2.43935666982025	GLI3/GSK3B/BCL2/CUL3/FBXW11/SMURF1/KIF3A/SMURF2/CSNK1A1/SPOP/GRK2	3.19694211910071
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	17/755	106/9376	1.99165313007622	EGFR/PDGFD/AKT3/GSK3B/BCL2/CREB3L2/AKT1/CREB5/EP300/CDKN1A/ATF4/HSP90AA1/MDM2/PDGFB/CREBBP/ERBB2/PTEN	3.03845734588098
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	18/755	115/9376	1.94377195508206	PLCB1/EGFR/ADCY7/BCL2/AKAP13/CREB3L2/JUND/CREB5/CDKN1A/ATF4/ARHGEF11/ADCY3/WNK1/OXSR1/GNAI1/RXRA/ATF2/GNA13	3.0134732268831
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	20/755	133/9376	1.86745008215904	PLCB1/AKT3/PPP1CB/GNGT1/GSK3B/CREB3L2/PPP3CB/MAPK8/AKT1/CREB5/GNB1/KIF5B/ATF4/PPP2R2A/GNAI1/PPP2R5E/PPP3CC/PPP2R3A/ATF2/GNG12	2.98156394443857
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	16/755	98/9376	2.02751723205839	PLCB1/PIP5K1B/DGKI/PIP5K1A/INPPL1/CDS1/INPP5F/PIKFYVE/PPIP5K2/PIK3C2B/PIK3C3/SYNJ1/MTM1/PIP5K1C/PTEN/PIP4P2	3.02590479252164
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	13/755	73/9376	2.21152136441985	TRIM5/MLLT1/NUP153/FURIN/XPO1/CCNT2/EP300/PDCD6IP/SERINC3/CPSF6/CREBBP/SUPT5H/CPSF7	3.0751144787641
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	17/755	108/9376	1.95477066470444	NUP153/TNPO1/XPO1/KPNA4/THOC7/KPNA1/EEF1A1/XPO6/UPF1/SUMO3/NUP58/NUP54/POM121/NUP50/IPO11/RANGAP1/SEC13	2.95323647375485
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	11/755	59/9376	2.31532158491413	EGFR/CTNNA1/AKT3/CTNNA2/GSK3B/AKT1/ELK1/CDKN1A/CDH1/ERBB2/PTEN	2.99916387702609
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	32/755	253/9376	1.57072481218752	CYTH3/NAIP/PLCB1/EGFR/ARPC5/TAB3/CAST/DOCK1/AKT3/WASL/GSK3B/ELMO1/BCL2/CD44/PTK2/MAPK8/AKT1/PRKCE/ITGB1/FBXW11/DIAPH1/TAB2/ACTN4/MDM2/RBX1/UBE2D3/MAP3K7/PIK3C3/ATG14/ATG5/MAP1LC3A/MAP1LC3B	2.72331870172659
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	23/755	166/9376	1.72064150642304	PLCB1/ADCY7/AKT3/PPP1CB/CREB3L2/PPP3CB/CNGA1/AKT1/IRS2/CREB5/PRKCE/ATP1A1/ATF4/MYLK/ADCY3/INSR/ATP1B3/GNAI1/PPP3CC/PPP1R12A/ATF2/GNA13/PDE5A	2.77219510756567
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	29/755	224/9376	1.6077578051088	ADCY7/AKT3/MAP2K4/CREB3L2/DLG1/XPO1/HLA-DMA/PPP3CB/MAPK8/AKT1/CREB5/EP300/GPS2/ELK1/CANX/CDKN1A/ATF4/ADCY3/TGFBR1/CREBBP/ELK4/SMAD2/HLA-B/PPP3CC/MSX2/ATF2/B2M/PTEN/LTBR	2.7244374401441
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	29/755	227/9376	1.58650990460075	PLCB1/EGFR/ADCY7/AKT3/GNGT1/ARHGEF12/GSK3B/AKAP13/CREB3L2/PTK2/PPP3CB/AKT1/CREB5/GNB1/ELK1/CDKN1A/ATF4/RHEB/ARHGEF11/ADCY3/MDM2/GNAI1/HLA-B/PPP3CC/ATF2/B2M/GNG12/GNA13/PDIA3	2.64716953970026
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	18/755	122/9376	1.83224405601998	PLCB1/NOTCH2/AKT3/NCOA2/GSK3B/AKT1/EP300/ATP1A1/NCOA1/RHEB/TBC1D4/MDM2/ATP1B3/MED13/CREBBP/SIN3A/MED4/RXRA	2.7380801782813
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	13/755	78/9376	2.06975717439294	CNOT6L/PAN3/XRN1/CNOT2/CNOT7/PABPC1/LSM6/EXOSC6/CNOT4/CNOT1/TENT4A/BTG3/MTREX	2.8074887824521
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	30/755	238/9376	1.56536256886861	RASA1/RALGAPA2/RASAL2/EGFR/RRAS2/PDGFD/AKT3/TIAM1/GNGT1/FLT4/RAP1B/GAB1/MAPK8/AKT1/PAK2/SHOC2/NF1/GNB1/ELK1/RALGAPA1/INSR/PDGFB/ABL2/PAK1/RGL1/RAB5B/AFDN/GNG12/RAB5A/RALGAPB	2.61438922397399
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	12/755	70/9376	2.12889309366131	AKT3/RAP1B/GAB1/AKT1/PAK2/EP300/CDKN1A/PDGFB/RBX1/CREBBP/PAK1/RAPGEF1	2.80543753640481
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	17/755	116/9376	1.81995889472482	VAV3/CLDN1/CTNNA1/CTNNA2/RAP1B/ARHGAP5/PTK2/NCF2/ITGB1/CLDN16/ACTN4/CDH5/CLDN4/OCLN/GNAI1/CD99L2/AFDN	2.6296374377223
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	20/755	144/9376	1.72479764532745	PLCB1/ATXN2/PUM2/AKT3/RORA/SEM1/ULK1/MAPK8/AKT1/MCU/RBPJ/PUM1/PSMD1/OPA1/PSMD14/ATG2B/PIK3C3/ATG14/AMBRA1/NFYA	2.59376373232667
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	14/755	89/9376	1.95347868144951	GABRB1/SLC38A1/GABRE/GABARAPL1/ADCY7/GLS/GABRA4/GNGT1/GNB1/ADCY3/ABAT/TRAK2/GNAI1/GNG12	2.67453668510847
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	24/755	184/9376	1.61980996256838	RASA1/SEMA6A/ARHGEF12/GSK3B/SEMA3B/PARD6B/PTK2/EPHB6/PPP3CB/RYK/PAK2/ITGB1/SRGAP2/FES/SEMA3C/NCK2/SEMA3F/GNAI1/NTN4/PAK1/SSH2/PPP3CC/SEMA7A/TRPC4	2.5127121963186
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	26/755	205/9376	1.57503472783072	UBE3A/TRAF3/SCIN/CREB3L2/DLG1/YWHAZ/CREB5/EP300/CDKN1A/RBPJ/ATF4/UBR4/ACTN4/MDM2/HNRNPK/CREBBP/RBL1/HLA-B/SP100/HDAC6/ATF2/GTF2H2/GTF2H1/IL6ST/LTBR/USP7	2.46344544503053
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	25/755	196/9376	1.58399783754561	AKT3/GNGT1/GSK3B/TRAF3/MAP2K4/PPP3CB/MAPK8/AKT1/PREX1/EP300/GNB1/CDKN1A/IFNGR1/PDGFB/TLR3/CREBBP/PIK3C3/HLA-B/PPP3CC/ATG14/GNG12/MAP2K7/MAP1LC3A/IL6ST/MAP1LC3B	2.44510900744044
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	16/755	110/9376	1.80633353401565	FBN1/THSD4/SMURF1/EP300/ACVR2B/SMURF2/RBX1/LEMD3/IGSF1/ACVR1/TGFBR1/CREBBP/RBL1/SMAD2/SKI/SIN3A	2.5173593086066
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	20/755	149/9376	1.66691852971243	CYTH3/PLCB1/AGPAT5/EGFR/PIP5K1B/RRAS2/PDGFD/DGKI/ADCY7/AKT3/PIP5K1A/GAB1/AKT1/RHEB/ADCY3/INSR/PDGFB/PLPP1/PIP5K1C/GNA13	2.42837609728476
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	7/755	34/9376	2.55675886248539	PRKAG2/RORA/FBXW11/NR1D2/PER3/FBXL3/RBX1	2.6910462712441
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	15/755	103/9376	1.80852568636276	PABPN1/PPP1CB/SMG7/FUS/SMG1/PABPC1/PPP2R2A/UPF1/CPSF6/SYMPK/PPP2R5E/BCL2L2-PABPN1/PPP2R3A/NUDT21/CPSF7	2.44164542265227
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	22/755	170/9376	1.6071055707051	EGFR/AKT3/TXNRD1/NFE2L2/GSK3B/GAB1/DVL3/ARID2/AKT1/GSTA4/ARID1A/ELK1/CDKN1A/ARID1B/GSTA3/CSNK1A1/SMARCC1/KEAP1/TGFBR1/SMAD2/SMARCD1/PTEN	2.36392386333531
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	25/755	200/9376	1.5523178807947	CYTH3/NAIP/ARPC5/TAB3/NCKAP1/TJP1/CLDN1/WASL/ARHGEF12/MAPK8/SEC24B/PAK2/ITGB1/CLDN16/TAB2/ARHGEF11/CLDN4/OCLN/TMED10/NCK2/MAP3K7/PAK1/ABI1/MYO5A/GNA13	2.3364564485125
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	18/755	133/9376	1.68070507394314	PRKAG2/EGFR/DEPP1/GABARAPL1/AKT3/MAPK8/AKT1/IRS2/EP300/CDKN1A/MDM2/INSR/FBXO25/TGFBR1/CREBBP/PTEN/STK11/USP7	2.33969163990827
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	17/755	125/9376	1.68892185430464	PLCB1/AKT3/BCL2/SGMS2/MAPK8/AKT1/PRKCE/SGMS1/SGPP1/PPP2R2A/NSMAF/GNAI1/PPP2R5E/PPP2R3A/ASAH1/GNA13/PTEN	2.29462076487979
NA	NA	hsa04519	Cadherin signaling	44/755	404/9376	1.35251458920727	GABRB1/GABRE/EGFR/RRAS2/ARPC5/VAV3/NCKAP1/TJP1/PCDH11Y/CTNNA1/CTNNA2/GABRA4/PPP1CB/FLT4/GSK3B/WWC1/DVL3/DAAM1/PTK2/YWHAZ/STK3/LHFPL2/MAPK8/RYK/SHOC2/EP300/LATS2/EVL/ACTN4/CDH5/PCDH1/AMOTL1/CSNK1A1/DSP/DSG2/DSC2/PKP2/CREBBP/MPDZ/TMC1/TAOK1/CDH1/ERBB2/AFDN	2.14340103963152
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	15/755	107/9376	1.74091724948939	PLCB1/PRKAG2/AKT3/CREB3L2/PPP3CB/AKT1/PPP4R3B/CREB5/EP300/ATF4/PPP4R3A/CPT1B/CREBBP/PPP3CC/ATF2	2.28100083918959
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	14/755	98/9376	1.77407757805109	PIP5K1B/ARPC5/VAV3/DOCK1/AKT3/PIP5K1A/SCIN/MARCKS/INPPL1/AKT1/PRKCE/PLPP1/PAK1/PIP5K1C	2.27955792869393
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	26/755	216/9376	1.49482462595045	PLCB1/POU2F1/VAV3/AKT3/NFE2L2/RAP1B/GSK3B/BCL2/TRAF3/MAP2K4/OLR1/PTK2/PPP3CB/MAPK8/NCF2/AKT1/TAB2/MIB1/ATF4/HSP90AA1/ATF6/PPARG/MAP3K7/PPP3CC/RXRA/MAP2K7	2.17726221257268
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	16/755	117/9376	1.69826229693779	MBD3/ARID2/ARID1A/EPC2/MTA1/ARID1B/BAZ2B/SMARCC1/SMARCA5/BAZ2A/EP400/BAZ1B/INO80D/SMARCD1/SS18/GATAD2B	2.24910521721744
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	10/755	62/9376	2.00299081392865	NOTCH2/CTBP2/DVL3/EP300/RBPJ/TLE3/CTBP1/CREBBP/CIR1/SPEN	2.34479551585094
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	7/755	37/9376	2.34945408985144	TFG/CDKN1A/PPARG/NCOA4/CDH1/RXRA/CCDC6	2.4338234973944
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	21/755	168/9376	1.5523178807947	CSHL1/CSH2/EGFR/CSH1/AKT3/CSF3R/PRLR/BCL2/PIAS1/AKT1/PIM1/EP300/CDKN1A/IL7/IFNGR1/PDGFB/CREBBP/AOX1/GH2/SOCS5/IL6ST	2.13767353391217
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	7/755	38/9376	2.28762635064482	NR3C2/NEDD4L/ATP1A1/HSD11B2/INSR/ATP1B3/SCNN1B	2.35361276439687
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	40/755	368/9376	1.34984163547365	ATXN2/NUP153/HNRNPA3/BCL2/COX7B2/SEM1/PPP3CB/ULK1/FUS/KIF5B/MCU/SOD1/CHMP2B/ATF4/C9orf72/PSMD1/ATF6/PSMD14/ATG2B/UBQLN4/NDUFS4/VAPB/NUP58/NUP54/PIK3C3/PPP3CC/POM121/ATG14/KLC1/NUP50/HDAC6/AMBRA1/NDUFV2/ANXA11/RAB5A/DNAH14/MAP1LC3A/MT-ND3/MAP1LC3B/SEC13	2.02610293969938
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	6/755	31/9376	2.40358897671438	IMMP2L/SEC61A1/IMMP1L/SGTA/SPCS2/SEC63	2.31638868205708
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	16/755	122/9376	1.62866138312887	VAV3/AKT3/GSK3B/DLG1/PPP3CB/MAPK8/AKT1/PAK2/PPP2R2A/NCK2/MAP3K7/PPP2R5E/PAK1/PPP3CC/PPP2R3A/MAP2K7	2.06829386109156
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	20/755	163/9376	1.52374761305001	AKT3/BCL2/TRAF3/MAP2K4/CREB3L2/YWHAZ/MAPK8/AKT1/CREB5/EP300/ELK1/TAB2/CDKN1A/ATF4/TLR3/TGFBR1/CREBBP/MAP3K7/ATF2/MAP2K7	1.99616122287183
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	6/755	32/9376	2.32847682119205	BCKDHB/ACSS1/ABAT/ACOX1/ECHDC1/SUCLG2	2.2276289184103
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	6/755	32/9376	2.32847682119205	ATG9B/GABARAPL1/ATG10/ATG2B/PIK3C3/ATG5	2.2276289184103
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	24/755	205/9376	1.45387821030528	AKT3/NEDD4/BCL2/TRAF3/MAP2K4/SEM1/HLA-DMA/CD44/MAPK8/AKT1/TAB2/CDKN1A/RBPJ/PSMD1/MDM2/PSMD14/MAP3K7/HLA-B/CIR1/SIN3A/B2M/MAP2K7/PDIA3/USP7	1.94441162535196
Organismal Systems	Immune system	hsa04611	Platelet activation	16/755	126/9376	1.57695784715652	PLCB1/ADCY7/AKT3/PPP1CB/ARHGEF12/RAP1B/AKT1/ITGB1/MYLK/SNAP23/COL3A1/ADCY3/COL1A1/GNAI1/PPP1R12A/GNA13	1.92947333996455
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	6/755	33/9376	2.25791691751957	STX7/SEC22B/VTI1A/SNAP23/GOSR1/STX18	2.14213109235537
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	11/755	78/9376	1.7513329937171	ARPC5/CTNNA1/DOCK1/CTNNA2/WASL/GAB1/ELMO1/PTK2/ITGB1/CDH1/CLTC	1.97181098873576
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	11/755	80/9376	1.70754966887417	EGFR/PDGFD/AKT3/GSK3B/GAB1/BCL2/AKT1/NF1/PDGFB/ERBB2/PTEN	1.88076337725545
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	26/755	233/9376	1.38576016826308	FBN2/DIAPH2/ANK3/PDLIM5/FBN3/FBN1/PLEC/DAAM1/SGCE/ITGB1/ATP1A1/ITGB4/SNTB1/DIAPH1/DSP/COL3A1/ATP1B3/DSG2/FMNL2/INF2/DSC2/PKP2/COL1A1/SPTAN1/CAPZA1/NEB	1.76453905259823
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	24/755	212/9376	1.40587279770086	PLCB1/EGFR/VAV3/PDGFD/ADCY7/AKT3/TIAM1/FLT4/RAP1B/PARD6B/AKT1/RAPGEF2/ITGB1/EVL/ADCY3/INSR/PDGFB/RAP1GAP/GNAI1/ARAP3/CDH1/RAPGEF1/AFDN/MAGI2	1.76886882057197
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	19/755	160/9376	1.47470198675497	NECTIN3/NRCAM/NLGN4Y/CLDN1/HLA-DMA/NRXN3/ITGB1/CLDN16/VSIR/CDH5/NEGR1/PTPRM/CLDN4/OCLN/IGSF11/HLA-B/CD99L2/CDH1/NRXN1	1.79221496398565
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	9/755	62/9376	1.80269173253578	PRKAG2/ADCY7/AKT3/AKT1/IRS2/SOD1/ADCY3/INSR/ATG5	1.87653560623181
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	7/755	44/9376	1.97567730282962	CREB3L2/CREB5/DYNC1LI1/DYNC1I1/ADCY3/RAB5B/RAB5A	1.91966508847908
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	18/755	154/9376	1.45151801840544	PLCB1/ADCY7/AKT3/PPP1CB/KCNE1/BCL2/CREB3L2/AKT1/CREB5/ATP1A1/ATF4/ADCY3/ATP1B3/PPP2R2A/GNAI1/PPP2R5E/PPP2R3A/ATF2	1.67187259519919
NA	NA	hsa04518	Integrin signaling	18/755	154/9376	1.45151801840544	EGFR/PDGFD/AKT3/FLT4/FBN1/GSK3B/PTK2/AKT1/ITGB1/LAMC1/ITGB4/SPP1/ACTN4/PDGFB/NCK2/COL1A1/CDH1/ERBB2	1.67187259519919
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	17/755	144/9376	1.46607799852833	PRKAG2/TAB3/AKT3/GSK3B/TRAF3/MAP2K4/TRA2A/MAPK8/AKT1/LPIN2/TAB2/CPT1B/C1QA/MAP3K7/LPIN1/ACOX1/MAP2K7	1.66790857670631
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	18/755	155/9376	1.44215338602863	STX7/SEC22B/OLR1/HLA-DMA/NCF2/PIKFYVE/ITGB1/SEC61A1/CANX/EEA1/DYNC1LI1/DYNC1I1/CTSL/PIK3C3/STX18/HLA-B/RAB5B/RAB5A	1.64259344261359
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	9/755	65/9376	1.71949057564952	PLCB1/PBX1/ADCY7/CREB3L2/CREB5/ATF4/NCEH1/ADCY3/ATF2	1.72251858385028
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	10/755	75/9376	1.65580573951435	SESN3/BCL2/SESN1/COP1/CDKN1A/RRM2B/MDM2/SHISA5/MDM4/PTEN	1.68741270305563
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	10/755	75/9376	1.65580573951435	PLCB1/ADCY7/CREB3L2/CREB5/ATP1A1/CANX/ATF4/ADCY3/ATP1B3/ATF2	1.68741270305563
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	8/755	56/9376	1.77407757805109	MGAT5/FUT8/STT3B/MAN2A1/MGAT4A/MAN1A2/GANAB/ALG2	1.71929672791389
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	20/755	178/9376	1.39534191532108	TBL1XR1/PLCB1/FRZB/GSK3B/CTBP2/DVL3/DAAM1/PPP3CB/MAPK8/RYK/FBXW11/EP300/CHD8/TLE3/CSNK1A1/RBX1/CTBP1/CREBBP/MAP3K7/PPP3CC	1.57585571829382
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	18/755	157/9376	1.42378200531489	GULP1/PBX1/DOCK1/DNMT3A/ELMO1/PTK2/DUSP16/TMEM30A/STAB1/PPARG/ATP11C/CPT1B/C1QA/ANO3/RAB14/RXRA/RAB5B/RAB5A	1.58464039243114
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	18/755	157/9376	1.42378200531489	RRAS2/AKT3/PPP1CB/PPP3CB/AKT1/FBXW11/MCU/CDKN1A/TRPM7/RHEB/MDM2/TGFBR1/RBL1/SMAD2/HLA-B/PPP3CC/HIPK3/PTEN	1.58464039243114
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	9/755	67/9376	1.66816249876446	PLCB1/PPP1CB/RAP1B/RPS6KA6/PPP3CB/EP300/ATF4/CREBBP/PPP3CC	1.6242327926116
NA	NA	hsa03272	Virion - Hepatitis viruses	7/755	48/9376	1.81103752759382	EGFR/CLDN1/CLDN16/PDCD6IP/CLDN4/OCLN/IST1	1.66704602921767
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	23/755	214/9376	1.33470322460853	TRIM5/AKT3/GNGT1/BCL2/PTK2/PPP3CB/MAPK8/AKT1/PAK2/FBXW11/GNB1/TAB2/CUL5/RBX1/GNAI1/MAP3K7/PAK1/HLA-B/PPP3CC/B2M/GNG12/MAP2K7/PDIA3	1.46572309476088
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	24/755	226/9376	1.31878333235656	RRAS2/VAV3/ADCY7/AKT3/TIAM1/GLI3/PPP1CB/RAP1B/CREB3L2/CNGA1/MAPK8/AKT1/CREB5/EP300/ATP1A1/ADCY3/ATP1B3/CREBBP/GNAI1/PAK1/ARAP3/ACOX1/PPP1R12A/AFDN	1.43555412078196
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	8/755	59/9376	1.68387024357391	ADCY7/AKT3/AKT1/IRS2/MGLL/ADCY3/INSR/GNAI1	1.55934408332075
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	12/755	99/9376	1.50527794501304	EGFR/ADCY7/NOTCH2/AKT3/BCL2/PTK2/MAPK8/AKT1/CDKN1A/ADCY3/MDM2/ERBB2	1.49563098034295
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	13/755	110/9376	1.46764599638772	EGFR/AKT3/BCL2/AKT1/EP300/CDKN1A/MKNK1/INSR/IFNGR1/RBX1/CREBBP/ERBB2/LTBR	1.45998269013624
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	9/755	70/9376	1.59666982024598	PRKAG2/AKT3/MAPK8/AKT1/IRS2/ACSL4/CPT1B/RXRA/STK11	1.48279754740018
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	6/755	41/9376	1.8173477628816	DAPK1/EGFR/CDKN1A/MDM2/CDH1/ERBB2	1.55210799845902
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4/755	23/9376	2.15974661675785	GLS/GLUD1/ATP1A1/ATP1B3	1.64790380513781
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	12/755	101/9376	1.47547046095338	PLCB1/AKT3/BCL2/MAPK8/AKT1/PIM1/PRKCE/DIAPH1/COL3A1/TGFBR1/COL1A1/SMAD2	1.42169868060741
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	10/755	82/9376	1.514456469068	KLRD1/HLA-DMA/CD74/CANX/HSP90AA1/CTSL/HLA-B/B2M/NFYA/PDIA3	1.38463248444533
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	33/755	333/9376	1.23066642801742	EGFR/NOTCH2/AKT3/GSK3B/UBE3A/TRAF3/PARD6B/CREB3L2/DLG1/DVL3/PTK2/AKT1/CREB5/ITGB1/LAMC1/EP300/ITGB4/SPP1/CDKN1A/RBPJ/UBR4/RHEB/CSNK1A1/MDM2/PPP2R2A/TLR3/CREBBP/COL1A1/RBL1/PPP2R5E/HLA-B/PPP2R3A/PTEN	1.26832494241481
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	11/755	93/9376	1.46885993021434	AKT3/BCL2/TRAF3/FHIT/PTK2/AKT1/ITGB1/LAMC1/CDKN1A/RXRA/PTEN	1.34468546059848
Human Diseases	Cancer: specific types	hsa05218	Melanoma	9/755	73/9376	1.53105325229066	EGFR/PDGFD/AKT3/AKT1/CDKN1A/MDM2/PDGFB/CDH1/PTEN	1.3479329321574
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	13/755	115/9376	1.4038353008926	PLCB1/ADCY7/AKT3/GNGT1/BCL2/CREB3L2/AKT1/CREB5/GNB1/ATF4/ADCY3/GNAI1/GNG12	1.28945012696877
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	17/755	158/9376	1.33617235308911	NIPBL/GSK3B/YWHAZ/WAPL/RAD21/EP300/TFDP2/CDKN1A/MDM2/RBX1/CREBBP/RBL1/CDKN1C/PPP2R5E/SMAD2/STAG2/STAG1	1.26110857036267
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	6/755	44/9376	1.69343768813967	FUT8/STT3B/MAN2A1/MGAT4A/MAN1A2/ALG2	1.36435286246464
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	7/755	54/9376	1.60981113563895	AMD1/DNMT3A/APIP/SMS/AHCYL2/GCLM/MTR	1.32989689715546
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	9/755	75/9376	1.49022516556291	AKT3/BCL2/AKT1/GSTA4/TOP2B/CDKN1A/GSTA3/MDM2/ERBB2	1.26136769150724
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	15/755	139/9376	1.34013054457097	PLCB1/EGFR/ADCY7/AKT3/NCOA2/BCL2/CREB3L2/AKT1/CREB5/NCOA1/ATF4/HSP90AA1/ADCY3/GNAI1/ATF2	1.19555030393069
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	16/755	150/9376	1.32464459161148	EGFR/CTNNA1/AKT3/CTNNA2/GSK3B/GAB1/BCL2/DVL3/AKT1/CDKN1A/CSNK1A1/TGFBR1/SMAD2/CDH1/RXRA/ERBB2	1.18611655637845
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	7/755	55/9376	1.5805418422637	SGMS2/B4GALT5/SGMS1/SGPP1/PSAP/PLPP1/ASAH1	1.27780301636915
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	10/755	86/9376	1.4440166332974	CTNNA1/CTNNA2/SGCE/ITGB1/ITGB4/SNTB1/DSP/DSG2/DSC2/PKP2	1.2241112791447
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	13/755	119/9376	1.35664755968613	TAB3/AKT3/TRAF3/MAP2K4/CREB3L2/MAPK8/AKT1/CREB5/TAB2/ATF4/MAP3K7/ATF2/MAP2K7	1.15866502324195
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	12/755	109/9376	1.36717905097515	RORA/HLA-DMA/PPP3CB/MAPK8/HSP90AA1/IFNGR1/TGFBR1/AHR/SMAD2/PPP3CC/RXRA/IL6ST	1.14104258724556
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	13/755	120/9376	1.34534216335541	AKT3/FRS2/RAP1B/GSK3B/GAB1/BCL2/RPS6KA6/MAPK8/AKT1/ATF4/MAP2K5/RAPGEF1/MAP2K7	1.12670143328659
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	19/755	187/9376	1.26177710096682	NEK7/NAIP/PLCB1/TAB3/GABARAPL1/BCL2/TRAF3/MAPK8/MCU/TAB2/TRPM7/GBP2/HSP90AA1/NAMPT/MAP3K7/ATG5/MAP1LC3A/PKN2/MAP1LC3B	1.07003657552649
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	16/755	154/9376	1.29023823858261	PLCB1/PRKAG2/EGFR/ADCY7/PPP1R12B/PPP1CB/PPP3CB/ELK1/CDKN1A/MYLK/MAP2K5/ADCY3/GNAI1/PPP3CC/PPP1R12A/EEF2	1.07468879952745
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	16/755	155/9376	1.28191412091433	PLCB1/EGFR/PBX1/ADCY7/RAP1B/GSK3B/CREB3L2/DVL3/CREB5/CDKN1A/ATF4/NCEH1/ADCY3/AHR/GNAI1/ATF2	1.04730688721691
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	6/755	48/9376	1.5523178807947	BCKDHB/HIBADH/AUH/ABAT/AOX1/MCCC2	1.13526106834584
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	6/755	48/9376	1.5523178807947	PLCB1/AKT3/AKT1/ATP1A1/ATP1B3/AMY2B	1.13526106834584
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	5/755	38/9376	1.63401882188916	NMNAT2/NADK2/NAMPT/AOX1/NT5C2	1.15890358357369
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	20/755	201/9376	1.23567592501071	MLLT1/JMJD1C/PBX1/FUT8/CDK14/KDM6A/BMP2K/PTK2/CCNT2/HPGD/FUS/CDKN1A/PPARG/MDM2/ELK4/EWSR1/SIN3A/RXRA/SS18/LMO2	0.999517734069008
Human Diseases	Substance dependence	hsa05032	Morphine addiction	10/755	91/9376	1.3646750600393	GABRB1/GABRE/ADCY7/GABRA4/GNGT1/GNB1/ADCY3/GNAI1/GNG12/GRK2	1.03446570350902
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	16/755	157/9376	1.26558400472434	CTNNA1/CTNNA2/PPP1CB/GSK3B/WWC1/PARD6B/DLG1/DVL3/YWHAZ/STK3/FBXW11/LATS2/PPP2R2A/TGFBR1/SMAD2/CDH1	0.993093468320125
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	18/755	180/9376	1.24185430463576	POU2F1/AKT3/PPP1CB/BCL2/TRAF3/SRPK1/HLA-DMA/AKT1/CD74/TAB2/RHEB/IFNGR1/TLR3/MAP3K7/HLA-B/SP100/B2M/PDIA3	0.969551503780757
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	4/755	29/9376	1.71290248915277	WWC1/STK3/LATS2/PAK1	1.13781931059747
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	11/755	103/9376	1.32625216999936	PLCB1/AKT3/MAP2K4/MAPK8/AKT1/IFNGR1/PPP2R2A/TGFBR1/C1QA/GNAI1/SMAD2	0.985240334284068
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	20/755	205/9376	1.2115651752544	PLCB1/AKT3/PPP1CB/GSK3B/COX7B2/MAPK8/NCF2/AKT1/TBC1D4/COL3A1/INSR/CPT1B/TGFBR1/NDUFS4/COL1A1/SMAD2/GFPT2/NDUFV2/MT-ND3/PTEN	0.906343985994816
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	21/755	217/9376	1.20179448835719	EGFR/ADCY7/NOTCH2/AKT3/BCL2/CREB3L2/KPNA4/RPS6KA6/AKT1/KPNA1/GSTA4/CREB5/CYP1B1/ATF4/HSP90AA1/GSTA3/ADCY3/AHR/GNAI1/RXRA/ATF2	0.890011112098055
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	15/755	149/9376	1.25018889728432	PLCB1/GABRB1/GABRE/ADCY7/GABRA4/GNGT1/MAPK8/GNB1/MGLL/ADCY3/NDUFS4/GNAI1/NDUFV2/GNG12/MT-ND3	0.910984941793798
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	14/755	138/9376	1.25985219310874	ADCY7/PPP1CB/CPEB4/RPS6KA6/YWHAZ/PPP3CB/SPDYA/FBXW11/ADCY3/SLK/RBX1/PPP2R5E/PPP3CC/CPEB2	0.910033211814006
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	12/755	116/9376	1.28467686686458	PLCB1/SLC38A1/ADCY7/GLS/GNGT1/PPP3CB/GNB1/ADCY3/GNAI1/PPP3CC/GNG12/GRK2	0.912968871460095
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	9/755	83/9376	1.34658900502673	ABCD3/FAR2/SOD1/ACSL4/GNPAT/IDH1/ACOX1/PEX3/CROT	0.938547269156506
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	8/755	73/9376	1.36093622425837	EGFR/AKT3/FHIT/AKT1/KIF5B/CDKN1A/RXRA/ERBB2	0.916137545505731
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	3/755	21/9376	1.77407757805109	COASY/DPYD/CSAD	1.05087855784654
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	4/755	31/9376	1.60239265114292	DPYD/ABAT/CSAD/ACOX1	0.994148245968853
NA	NA	hsa04981	Folate transport and metabolism	4/755	31/9376	1.60239265114292	ABCG2/SLCO2B1/ABCC3/MTR	0.994148245968853
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	6/755	52/9376	1.43290881304126	ADCY7/HSD17B1/CYP19A1/CYP1B1/ADCY3/INSR	0.926354590577809
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	7/755	63/9376	1.37983811626196	KMT2C/KMT5B/SETD2/KMT2B/NSD1/ASH1L/EHMT1	0.89516750392709
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	7/755	63/9376	1.37983811626196	RAD23B/MNAT1/UVSSA/RBX1/XPC/GTF2H2/GTF2H1	0.89516750392709
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/755	12/9376	2.06975717439294	CD46/NPC1	1.09730010250124
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	14/755	142/9376	1.22436339893667	AKT3/JUND/PPP3CB/MAPK8/NCF2/AKT1/TAB2/PPARG/IFNGR1/TGFBR1/MAP3K7/PPP3CC/MAP2K7/FOSL2	0.797226156457292
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	9/755	86/9376	1.29961496996766	PLCB1/ADCY7/CREB3L2/CREB5/ATP1A1/ATF4/ADCY3/ATP1B3/ATF2	0.826009740703469
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	22/755	235/9376	1.16258700859518	PRKAG2/ADCY7/FRS2/CREB3L2/COX7B2/RPS6KA6/CREB5/ARID1A/MGLL/KDM3B/ARID1B/RHEB/PPARG/SMARCC1/ADCY3/ACSL4/CPT1B/NDUFS4/NDUFV2/ATF2/SMARCD1/MT-ND3	0.746970084021673
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	10/755	98/9376	1.26719827003649	PLCB1/ADCY7/CREB3L2/CREB5/PRKCE/ATP1A1/ATF4/ADCY3/ATP1B3/ATF2	0.786864201038498
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	9/755	87/9376	1.28467686686458	EGFR/AKT3/GSK3B/BCL2/MAPK8/AKT1/CDKN1A/TGFBR1/SMAD2	0.789419070475923
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	8/755	76/9376	1.30721505751133	PLCB1/ADCY7/ATP1A1/MYLK/ADCY3/ATP1B3/SLC4A2/GNAI1	0.79577100549726
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	11/755	110/9376	1.24185430463576	ADCY7/AKT3/CPEB4/RPS6KA6/MAPK8/AKT1/SPDYA/HSP90AA1/ADCY3/GNAI1/CPEB2	0.755064944489327
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	15/755	156/9376	1.19409067753439	EGFR/CLDN1/AKT3/GSK3B/TRAF3/PIAS1/YWHAZ/AKT1/CLDN16/CDKN1A/CLDN4/OCLN/PPP2R2A/TLR3/RXRA	0.723405499743688
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	28/755	308/9376	1.12895845875978	PLCB1/CREB3L2/COX7B2/SEM1/NRF1/ULK1/MAPK8/CREB5/EP300/KIF5B/SOD1/PSMD1/PPARG/PSMD14/ATG2B/NDUFS4/CREBBP/PIK3C3/ATG14/KLC1/SIN3A/AP2A2/AMBRA1/CLTC/NDUFV2/MAP2K7/DNAH14/MT-ND3	0.68100410225074
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	8/755	77/9376	1.29023823858261	EGFR/AKT3/MAPK8/AKT1/CDKN1A/TGFBR1/SMAD2/ERBB2	0.756766955024256
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	23/755	250/9376	1.1425059602649	ABCA5/GPR155/OSBPL3/CD164/SUMF1/PIKFYVE/ARL8B/OSBP/SLC36A4/CTSL/VPS13C/PSAP/TLR3/SLC17A5/NPC1/AP2A2/ASAH1/CLTC/ENTPD4/ARL8A/BORCS5/CLCN7/IDS	0.675838755605932
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	21/755	227/9376	1.1488519998833	EGFR/AKT3/NFE2L2/MAP2K4/COX7B2/PTK2/MAPK8/NCF2/AKT1/GSTA4/SOD1/CYP1B1/GSTA3/KEAP1/ABL2/NDUFS4/AHR/NDUFV2/MAP2K7/MT-ND3/PTEN	0.671832610026895
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	9/755	89/9376	1.25580772378897	PLCB1/EGFR/TJP1/PDGFD/ADCY7/MAP2K5/ADCY3/PDGFB/GNAI1	0.717548441216961
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	17/755	181/9376	1.16638249606674	AKT3/ARHGEF12/BCL2/HLA-DMA/PPP3CB/MAPK8/AKT1/CD74/EP300/EEA1/IFNGR1/CREBBP/PIK3C3/PPP3CC/RAB5B/RAB5A/NFYA	0.668884831443493
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	11/755	112/9376	1.21967833491012	AKT3/BCL2/HLA-DMA/MAPK8/AKT1/ITGB1/LAMC1/TAB2/IFNGR1/GNAI1/MAP3K7	0.692113400021699
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	8/755	78/9376	1.27369672270335	HLA-DMA/NCF2/EEF1A1/ITGB1/ELK1/TAB2/IFNGR1/MAP3K7	0.718294298161259
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	18/755	193/9376	1.15820608722506	PLCB1/VAV3/ADCY7/AKT3/TIAM1/GNGT1/RAP1B/GSK3B/ELMO1/PTK2/AKT1/PREX1/GNB1/ADCY3/GNAI1/PAK1/GNG12/GRK2	0.657188330892764
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	5/755	45/9376	1.37983811626196	ABCD3/ABCA5/ABCG2/ABCC3/ABCB7	0.75582455513698
Organismal Systems	Digestive system	hsa04976	Bile secretion	9/755	90/9376	1.24185430463576	ADCY7/ABCG2/ATP1A1/ABCC3/NCEH1/ADCY3/ATP1B3/SLC4A2/RXRA	0.682246047136539
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/755	14/9376	1.77407757805109	FUT8/B3GNT2	0.857717910187188
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	13/755	138/9376	1.16986275074383	PRKAG2/AKT3/PPP1CB/GSK3B/INPPL1/MAPK8/AKT1/IRS2/ELK1/MKNK1/RHEB/INSR/RAPGEF1	0.5948795073755
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	7/755	69/9376	1.25985219310874	PPP1CB/CREB3L2/PPP3CB/CREB5/ATF4/PPP3CC/ATF2	0.641100870276568
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	9/755	93/9376	1.20179448835719	PLCB1/EGFR/ADCY7/MAP2K4/MAPK8/ELK1/ATF4/ADCY3/MAP2K7	0.578744518429571
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	6/755	59/9376	1.26290268268044	GSTA4/SMS/RRM2B/GSTA3/GCLM/IDH1	0.599464220850516
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	2/755	15/9376	1.65580573951435	ALPP/TPK1	0.752211574241635
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	9/755	94/9376	1.18900944060871	TAB3/USP25/GSK3B/TRAF3/JUND/MAPK8/TAB2/HSP90AA1/MAP3K7	0.545013089767092
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	7/755	71/9376	1.22436339893667	EGFR/GLS/AKT3/AKT1/IDH1/ERBB2/PTEN	0.561569209558437
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	4/755	37/9376	1.34254519420082	GLS/GLUD1/ABAT/GFPT2	0.617801338211714
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	5/755	49/9376	1.26719827003649	CREB3L2/CREB5/ATF4/GNAI1/ATF2	0.554933553889758
Organismal Systems	Digestive system	hsa04978	Mineral absorption	6/755	61/9376	1.22149603734665	TRPV6/ATP1A1/TRPM7/ATP1B3/SLC40A1/FTH1	0.513593762044489
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	10/755	109/9376	1.13931587581263	AKT3/TRAF3/MAP2K4/MAPK8/AKT1/SPP1/TAB2/TLR3/MAP3K7/MAP2K7	0.432936865432383
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	12/755	134/9376	1.11210833250964	PLCB1/ADCY7/PPP1R12B/PPP1CB/ARHGEF12/CALD1/PRKCE/MYLK/ARHGEF11/ADCY3/PPP1R12A/GNA13	0.386801011860934
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	3/755	28/9376	1.33055818353832	A4GALT/B3GNT2/ST3GAL6	0.518379559875881
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	14/755	158/9376	1.10037723195574	AKT3/RICTOR/GSK3B/DVL3/RPS6KA6/ULK1/AKT1/LPIN2/RHEB/INSR/LPIN1/PTEN/STK11/SEC13	0.376552641302744
NA	NA	hsa04081	Hormone signaling	19/755	219/9376	1.07740784420454	CSHL1/PLCB1/CSH2/CSH1/ADCY7/GNGT1/PRLR/IRS2/GNB1/OPRK1/ADCY3/INSR/SLC40A1/ACVR1/GNAI1/GH2/GNG12/GNA13/STK11	0.343013106245991
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/755	17/9376	1.46100506427737	TXNRD1/MTR	0.562983575335145
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/755	17/9376	1.46100506427737	PCDH11Y/PCDH1	0.562983575335145
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	7/755	76/9376	1.14381317532241	SLC27A6/OLR1/PPARG/ACSL4/CPT1B/ACOX1/RXRA	0.372515449135659
Human Diseases	Cancer: specific types	hsa05214	Glioma	7/755	76/9376	1.14381317532241	EGFR/AKT3/AKT1/CDKN1A/MDM2/PDGFB/PTEN	0.372515449135659
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/755	29/9376	1.28467686686458	GNGT1/CNGA1/GNB1	0.454355036386318
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	4/755	41/9376	1.2115651752544	SEM1/UIMC1/SSBP1/BABAM2	0.401753103905306
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	5/755	53/9376	1.17156066475072	PLCB1/ATP1A1/ATP1B3/AP2A2/CLTC	0.370644964697207
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	9/755	101/9376	1.10660284571503	PLCB1/ADCY7/GSK3B/CREB3L2/DVL3/EP300/ADCY3/CREBBP/GNAI1	0.318751925825569
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	6/755	65/9376	1.14632705043301	AGPAT5/DGKI/LPIN2/MGLL/PLPP1/LPIN1	0.350318784180487
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	7/755	77/9376	1.12895845875978	AKT3/CTBP2/AKT1/CDKN1A/MDM2/TGFBR1/CTBP1	0.336246183951689
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	3/755	30/9376	1.24185430463576	ABCG2/ABCC3/MTR	0.39262852821278
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	9/755	103/9376	1.08511541181766	COL17A1/COL19A1/COL28A1/ATP1A1/SLC36A4/COL3A1/ATP1B3/SLC15A1/COL1A1	0.257037790099966
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	8/755	91/9376	1.09174004803144	VAV3/AKT3/GSK3B/PPP3CB/INPPL1/AKT1/DAPP1/PPP3CC	0.260236971830667
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	32/755	388/9376	1.02420973578207	PLCB1/AKT3/RTN4/GSK3B/COX7B2/DVL3/SEM1/PPP3CB/ULK1/MAPK8/AKT1/IRS2/BACE2/KIF5B/MCU/ATF4/PSMD1/ATF6/CSNK1A1/INSR/PSMD14/ATG2B/NDUFS4/PIK3C3/PPP3CC/ATG14/SLC39A8/KLC1/AMBRA1/NDUFV2/MAP2K7/MT-ND3	0.144130094737661
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	9/755	105/9376	1.06444654683065	RRAS2/AKT3/ARHGEF12/PPP3CB/MAPK8/AKT1/MDM2/PAK1/PPP3CC	0.19652205753981
Organismal Systems	Digestive system	hsa04970	Salivary secretion	8/755	93/9376	1.06826176742861	PLCB1/TRPV6/ADCY7/ATP1A1/ADCY3/ATP1B3/SLC4A2/AMY2B	0.195774047345115
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	3/755	32/9376	1.16423841059603	BIRC6/BCL2/MAPK8	0.275399786523307
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	6/755	69/9376	1.07987330837892	VAV3/AKT3/MAP2K4/MAPK8/AKT1/MAP2K7	0.1970614405866
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	12/755	144/9376	1.03487858719647	AKT3/GSK3B/TBX3/DVL3/AKT1/KAT6A/ACVR2B/PCGF3/ACVR1/SMAD2/SMARCAD1/IL6ST	0.124816650672369
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	13/755	157/9376	1.02828700383853	PRKAG2/AKT3/GSK3B/COX7B2/MAPK8/AKT1/IRS2/ATF4/PPARG/INSR/NDUFS4/RXRA/NDUFV2	0.105773082153597
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	6/755	71/9376	1.04945434194571	AKT3/GSK3B/PRLR/MAPK8/AKT1/SOCS5	0.123781489526849
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	6/755	71/9376	1.04945434194571	EGFR/TJP1/MAP2K4/MAPK8/PAK1/GIT1	0.123781489526849
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	5/755	59/9376	1.0524189022337	DPYD/RRM2B/DUT/ENTPD4/NT5C2	0.1195242896154
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	8/755	97/9376	1.02420973578207	PLCB1/ADCY7/GNGT1/GNB1/PER3/ADCY3/GNAI1/GNG12	0.0709260250242291
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	4/755	47/9376	1.05689728054107	MAPK8/IRS2/PRKCE/INSR	0.115718603330675
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	7/755	85/9376	1.02270354499416	ADK/GDA/RRM2B/DUT/GMPS/ENTPD4/NT5C2	0.0622231794505513
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	12/755	148/9376	1.00690889565062	EGFR/NOTCH2/AKT3/FLT4/GSK3B/DVL3/AKT1/NCOA1/CDKN1A/CSNK1A1/ERBB2/PTEN	0.0250706728376299
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	5/755	60/9376	1.03487858719647	AKT3/PTK2/PPP3CB/AKT1/PPP3CC	0.080204744869184
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/755	22/9376	1.12895845875978	FTCD/CARNMT1	0.179201971446807
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	22/755	275/9376	0.993483443708609	GSK3B/CREB3L2/COX7B2/SEM1/PPP3CB/MAPK8/NCF2/CREB5/LAMC1/KIF5B/MCU/SOD1/ATF4/PSMD1/PSMD14/NDUFS4/C1QA/PPP3CC/KLC1/NDUFV2/ATF2/MT-ND3	-0.0324578861319242
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	3/755	36/9376	1.03487858719647	B4GALT5/ST6GALNAC3/C1GALT1	0.0620464571973516
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/755	23/9376	1.07987330837892	GLS/GLUD1	0.113493350103091
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/755	23/9376	1.07987330837892	LNPEP/THOP1	0.113493350103091
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/755	37/9376	1.00690889565062	PLCB1/HBB/THOP1	0.012460618484153
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	8/755	102/9376	0.974003376184911	PLCB1/ADCY7/RAP1B/ATP1A1/ADCY3/ATP1B3/SLC4A2/AMY2B	-0.0781202782186894
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	10/755	128/9376	0.970198675496689	ADK/GDA/ADCY7/FHIT/RRM2B/ADCY3/GMPS/PDE5A/ENTPD4/NT5C2	-0.100460869391049
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	7/755	90/9376	0.96588668138337	EGFR/AKT3/PPP3CB/AKT1/IFNGR1/PPP3CC/PTEN	-0.0962301531740599
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	8/755	103/9376	0.964547032726805	PLCB1/PTK2/LAMC1/ACTN4/COL3A1/COL1A1/RAB5B/RAB5A	-0.107063481992084
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	4/755	51/9376	0.974003376184911	CEPT1/PAFAH1B1/PLPP1/LPCAT1	-0.0550881146257338
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	5/755	65/9376	0.955272542027509	PLCB1/AKT3/AKT1/SPP1/TRPC4	-0.107081149042776
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	4/755	52/9376	0.955272542027509	VAPA/NCEH1/VAPB/NPC1	-0.0957094999443771
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	3/755	39/9376	0.955272542027509	FTCD/AHCYL2/MTR	-0.0828291361288782
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	7/755	93/9376	0.934729046500036	NOTCH2/HLA-DMA/PPP3CB/MAPK8/RBPJ/IFNGR1/PPP3CC	-0.187196423739341
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	37/755	480/9376	0.957262693156733	PLCB1/ATXN2/GSK3B/BCL2/COX7B2/DVL3/SEM1/PPP3CB/ULK1/MAPK8/FUS/KIF5B/MCU/SOD1/CHMP2B/ATF4/C9orf72/PSMD1/ATF6/CSNK1A1/PSMD14/ATG2B/NDUFS4/VAPB/PIK3C3/UBE2G1/PPP3CC/ATG14/KLC1/AMBRA1/NDUFV2/RAB5A/MAP2K7/DNAH14/MAP1LC3A/MT-ND3/MAP1LC3B	-0.284453101885998
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	2/755	27/9376	0.919892077507972	ELOVL7/ACOX1	-0.123354518555989
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	3/755	41/9376	0.908673881440801	GABRB1/GABRE/GABRA4	-0.173424343371553
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	6/755	82/9376	0.908673881440801	DPYD/GSTA4/RRM2B/GSTA3/DUT/GMPS	-0.245799436956166
Human Diseases	Infectious disease: viral	hsa05162	Measles	10/755	136/9376	0.913128165173354	AKT3/GSK3B/BCL2/TRAF3/MAPK8/AKT1/TAB2/MAP3K7/CD46/EIF3H	-0.301990133726117
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	4/755	56/9376	0.887038789025544	NAIP/SEC22B/EEF1A1/BCL2L13	-0.250897127001857
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/755	28/9376	0.887038789025544	ALPP/PTS	-0.177145161560333
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	5/755	70/9376	0.887038789025544	HLA-DMA/SGCE/SNTB1/ABL2/HLA-B	-0.280722437939337
NA	NA	hsa04382	Cornified envelope formation	16/755	217/9376	0.915652943510239	TJP1/CLDN1/FURIN/PLEC/COL17A1/CLDN16/DST/ITGB4/CLDN4/DSP/OCLN/PPP2R2A/DSG2/PKP2/PPP2R5E/PPP2R3A	-0.372011238561539
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	3/755	43/9376	0.866409979978438	ACSL4/CPT1B/ACOX1	-0.259823184454003
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	4/755	57/9376	0.871476705007552	ACSL4/ELOVL7/CPT1B/ACOX1	-0.288014872623538
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	24/755	323/9376	0.922740040596231	EGFR/NOTCH2/FOXP1/GLS/DNMT3A/BCL2/DICER1/MARCKS/RDX/CD44/PIM1/IRS2/PRKCE/EP300/CDKN1A/CYP1B1/MDM2/PDGFB/HNRNPK/CREBBP/MDM4/ZEB2/ERBB2/PTEN	-0.418157381990501
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	7/755	99/9376	0.878078801257609	PLCB1/ADCY7/PPP1CB/MAPK8/PRKCE/ADCY3/ASIC3	-0.360888742125807
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	3/755	44/9376	0.846718844069837	MNAT1/GTF2H2/GTF2H1	-0.301583815578658
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	3/755	44/9376	0.846718844069837	ICA1/HLA-DMA/HLA-B	-0.301583815578658
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	2/755	30/9376	0.827902869757174	IDH1/SUCLG2	-0.279384082324464
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	3/755	45/9376	0.827902869757174	KLRD1/HLA-DMA/HLA-B	-0.342449141719173
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/755	15/9376	0.827902869757174	ST6GALNAC3	-0.197396035841786
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	6/755	88/9376	0.846718844069837	F13A1/CD59/TFPI/C1QA/CD46/SERPINE2	-0.427512966102521
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	2/755	31/9376	0.801196325571459	TKT/RPIA	-0.328092190119375
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	3/755	46/9376	0.809904981284192	SEM1/PSMD1/PSMD14	-0.382462731265627
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	6/755	89/9376	0.837205149192648	CD44/ITGB1/LAMC1/ITGB4/SPP1/COL1A1	-0.456644505117944
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	17/755	238/9376	0.887038789025544	EGFR/TRAF3/F13A1/MAPK8/TAB2/RPL37A/RPS29/TLR3/C1QA/MAP3K7/RPL13A/RPS19/RPS23/RPL27A/RPS15A/RPL21/IL6ST	-0.522363150587892
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/755	16/9376	0.776158940397351	A4GALT	-0.265180821341308
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	12/755	173/9376	0.861401829805152	PABPN1/AKT3/TRAF3/XPO1/HLA-DMA/AKT1/KPNA1/EP300/IFNGR1/TLR3/CREBBP/BCL2L2-PABPN1	-0.54449779913903
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	19/755	268/9376	0.880419096570129	NFE2L2/COX7B2/SEM1/MAPK8/KIF5B/MCU/SOD1/ATF4/PSMD1/ATF6/KEAP1/PSMD14/NDUFS4/GNAI1/UBE2G1/SLC39A8/KLC1/NDUFV2/MT-ND3	-0.587757267357005
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	2/755	33/9376	0.752638972506522	BCKDHB/IDH1	-0.421235886608154
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	4/755	63/9376	0.788478923578261	GLI3/GSK3B/DVL3/CDKN1A	-0.498493399956299
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/755	17/9376	0.730502532138683	CSAD	-0.329112757661698
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/755	17/9376	0.730502532138683	GLUD1	-0.329112757661698
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/755	18/9376	0.689919058130979	ACSL4	-0.389672805356512
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/755	18/9376	0.689919058130979	MTR	-0.389672805356512
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	9/755	137/9376	0.815816696476048	AKT3/BCL2/MAPK8/AKT1/ATF4/NOL3/PARP4/CTSL/SPTAN1	-0.642655679111464
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	4/755	66/9376	0.752638972506522	HSD17B1/CYP19A1/CYP1B1/HSD11B2	-0.596772352779812
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	4/755	66/9376	0.752638972506522	RORA/HLA-DMA/IFNGR1/SMAD2	-0.596772352779812
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	3/755	51/9376	0.730502532138683	TJP1/SEC61A1/ADCY3	-0.571078287184057
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/755	19/9376	0.653607528755664	IDS	-0.447257077189844
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/755	19/9376	0.653607528755664	BCKDHB	-0.447257077189844
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/755	37/9376	0.671272597100412	PNMT/AOX1	-0.592880101243408
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/755	20/9376	0.620927152317881	LSS	-0.502195550525599
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/755	20/9376	0.620927152317881	CYB5R4	-0.502195550525599
Organismal Systems	Endocrine system	hsa04924	Renin secretion	4/755	69/9376	0.719915538919282	PLCB1/PPP3CB/GNAI1/PPP3CC	-0.691017418793337
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	2/755	38/9376	0.653607528755664	GNPDA1/GFPT2	-0.633160187661093
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/755	21/9376	0.591359192683696	CHST11	-0.554765923269595
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/755	39/9376	0.636848361351673	HLA-DMA/HLA-B	-0.672507177392631
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	7/755	116/9376	0.749394839004339	GLUD1/TKT/ACSS1/IDH1/ACOX1/SUCLG2/RPIA	-0.803699694802109
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	4/755	72/9376	0.689919058130979	TRAF3/MAPK8/MAP3K7/ATG5	-0.781603982121567
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	8/755	133/9376	0.746980032863616	KLRD1/VAV3/PPP3CB/SH3BP2/IFNGR1/PAK1/HLA-B/PPP3CC	-0.869669882743249
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/755	23/9376	0.539936654189461	RXYLT1	-0.653711877414269
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/755	23/9376	0.539936654189461	SSBP1	-0.653711877414269
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	6/755	105/9376	0.709631031220435	TAB3/BCL2/TRAF3/TAB2/MAP3K7/LTBR	-0.885445535820884
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	6/755	105/9376	0.709631031220435	ADCY7/SGCE/ITGB1/ITGB4/SNTB1/ADCY3	-0.885445535820884
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/755	42/9376	0.591359192683696	CYP1B1/AOX1	-0.785439560919969
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	4/755	75/9376	0.66232229580574	TKT/MTR/IDH1/RPIA	-0.868857366234732
Organismal Systems	Nervous system	hsa04730	Long-term depression	3/755	60/9376	0.620927152317881	PLCB1/GNAI1/GNA13	-0.871693594236471
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	4/755	78/9376	0.636848361351673	MAPK8/ITGB1/C1QA/GNAI1	-0.953061289271416
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/755	26/9376	0.477636271013754	ACOX1	-0.789285589209879
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/755	26/9376	0.477636271013754	SLC19A3	-0.789285589209879
Genetic Information Processing	Transcription	hsa03040	Spliceosome	15/755	243/9376	0.766576731256643	HNRNPA3/HNRNPU/HNRNPC/TRA2A/THOC7/SNRNP70/FUS/SRSF10/LSM6/HNRNPK/SF3B1/DDX42/RBM25/DHX15/RBM17	-1.09099019087958
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/755	27/9376	0.459946038753986	ABAT	-0.83160434463128
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	2/755	47/9376	0.528448640270537	ACSS1/ACYP2	-0.95904873181386
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/755	28/9376	0.443519394512772	ELOVL7	-0.872669882996546
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	5/755	99/9376	0.627199143755435	PRKAG2/SGCE/ITGB1/ITGB4/SNTB1	-1.10349663111331
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	6/755	115/9376	0.647923985027354	PLCB1/GABRB1/GNGT1/GNB1/GNAI1/GNG12	-1.12418221291128
Human Diseases	Substance dependence	hsa05034	Alcoholism	11/755	191/9376	0.715204049790229	PPP1CB/GNGT1/CREB3L2/CREB5/GNB1/ATF4/PKIA/GNAI1/HDAC6/ATF2/GNG12	-1.17676895938855
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	5/755	100/9376	0.620927152317881	CSF3R/HLA-DMA/CD44/CD59/IL7	-1.12777535358476
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	2/755	50/9376	0.496741721854305	AMD1/SMS	-1.05586529515561
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	2/755	50/9376	0.496741721854305	HLA-DMA/LTBR	-1.05586529515561
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	3/755	68/9376	0.547876899104012	AKT3/AKT1/PIM1	-1.10729479401832
Organismal Systems	Sensory system	hsa04742	Taste transduction	4/755	86/9376	0.577606653318959	PLCB1/GABRA4/SCN2A/SCNN1B	-1.16449795150269
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/755	31/9376	0.40059816278573	ACSS1	-0.98921240816349
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	3/755	70/9376	0.532223273415326	GSTA4/CYP1B1/GSTA3	-1.1624824306091
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	9/755	168/9376	0.665279091769158	BCL2/GLUD1/MAPK8/CHMP2B/TRPM7/HSP90AA1/IFNGR1/FTH1/TLR3	-1.29549314199747
Human Diseases	Immune disease	hsa05310	Asthma	1/755	32/9376	0.388079470198676	HLA-DMA	-1.02608630140135
NA	NA	hsa04082	Neuroactive ligand signaling	11/755	199/9376	0.686452128190622	PLCB1/GABRB1/GABRE/ADCY7/GABRA4/GNGT1/GNB1/OPRK1/ADCY3/GNAI1/GNG12	-1.3230014531024
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	8/755	154/9376	0.645119119291305	COASY/NMNAT2/ALPP/NADK2/PDXK/GCLM/TPK1/PTS	-1.31404638315953
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	2/755	54/9376	0.459946038753986	HLA-DMA/HLA-B	-1.17776807503696
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3/755	73/9376	0.510351084096888	GSTA4/GSTA3/AOX1	-1.24283938775264
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/755	36/9376	0.344959529065489	AMY2B	-1.16526911808191
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/755	36/9376	0.344959529065489	SSBP1	-1.16526911808191
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/755	37/9376	0.335636298550206	GFPT2	-1.19822082097097
Cellular Processes	Cell motility	hsa04814	Motor proteins	10/755	194/9376	0.640131084863795	KIF5B/KIF3A/DYNC1LI1/DYNC1I1/KIF21A/KIF27/KLC1/MYO5A/DNAH14/CAPZA1	-1.49884542581733
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3/755	79/9376	0.471590242266745	GSTA4/CYP1B1/GSTA3	-1.39570376626397
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	3/755	79/9376	0.471590242266745	SYT1/AP2A2/CLTC	-1.39570376626397
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/755	43/9376	0.288803326659479	PLPP1	-1.38322746272965
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/755	44/9376	0.282239614689946	PARP4	-1.41220826760752
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	3/755	87/9376	0.428225622288194	COX7B2/ATP1A1/ATP1B3	-1.58555067275599
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	2/755	67/9376	0.370702777503212	MINPP1/ACSS1	-1.5297553917928
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/755	46/9376	0.269968327094731	FTH1	-1.46879128877745
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	1/755	49/9376	0.253439654007298	C1GALT1	-1.55050175264352
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	15/755	298/9376	0.625094448642162	CSHL1/CSH2/CSH1/CSF3R/RELL1/PRLR/IL7/ACVR2B/ACVRL1/IFNGR1/ACVR1/TGFBR1/GH2/IL6ST/LTBR	-1.94632430289263
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	1/755	50/9376	0.248370860927152	HBB	-1.57696188465867
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	12/755	254/9376	0.586702821087761	PLCB1/EGFR/PDGFD/ADCY7/FLT4/PPP3CB/MCU/MYLK/ADCY3/PDGFB/PPP3CC/ERBB2	-1.97612565632566
Genetic Information Processing	Translation	hsa03010	Ribosome	10/755	222/9376	0.55939383091701	RPL37A/MRPL1/RPS29/RPL13A/RPS19/RPS23/RPL27A/RPS15A/MRPS6/RPL21	-1.96608322722352
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/755	54/9376	0.229973019376993	POLI	-1.67930106947544
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	1/755	63/9376	0.197119730894565	HPGD	-1.89215430383969
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	7/755	195/9376	0.445793852946171	PLCB1/AKT3/NCF2/AKT1/CLCN3/MAP3K7/HDAC6	-2.31432284292816
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	4/755	138/9376	0.359957769459641	COX7B2/NDUFS4/NDUFV2/MT-ND3	-2.24150383257106
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/755	68/9376	0.182625633034671	AOX1	-2.00183175668555
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	2/755	95/9376	0.261443011502266	HLA-DMA/CTSL	-2.14105941732281
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	2/755	99/9376	0.250879657502174	HLA-DMA/C1QA	-2.21740846459457
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	2/755	100/9376	0.248370860927152	IL6ST/LTBR	-2.23616337404711
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	1/755	83/9376	0.149621000558526	ZDHHC1	-2.30278767098306
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	3/755	143/9376	0.260528875098412	HLA-DMA/ACTN4/C1QA	-2.63692703372037
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	3/755	183/9376	0.203582672891108	XRN1/XPO1/REXO1	-3.21971852516559
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	10/755	370/9376	0.335636298550206	CSHL1/CSH2/GABRB1/GABRE/CSH1/GABRA4/PRLR/OPRK1/PGRMC2/GH2	-3.85852286591213
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	4/755	449/9376	0.110632900190268	GNB1/ADCY3/ANO2/GRK2	-5.71520422883007