category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	8/110	93/9376	7.33216031280547	FYN/FER/ARHGAP29/TGFBR2/RAP1B/ROCK1/ROCK2/TCF7L1	6.68628729545251
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	11/110	203/9376	4.61871921182266	LAMA2/PTEN/GSK3B/HGF/ITGB1/FYN/RAP1B/ROCK1/AKT3/ROCK2/TNXB	5.6791460972309
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	13/110	300/9376	3.69357575757576	MECOM/HGF/PPP3CA/RAPGEF2/TGFBR2/NF1/RAP1B/MAP2K5/ANGPT1/FGF7/AKT3/RPS6KA3/MAP3K2	5.16628560424833
Organismal Systems	Immune system	hsa04611	Platelet activation	8/110	126/9376	5.41183261183261	ITGB1/FYN/ITPR2/RAP1B/GNAQ/ROCK1/AKT3/ROCK2	5.43211887883018
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	8/110	138/9376	4.94123847167325	GSK3B/ITGB1/ELMO1/GNAQ/ROCK1/AKT3/RPS6KA3/ROCK2	5.08181803890454
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	6/110	80/9376	6.39272727272727	PTEN/GSK3B/HGF/JAK2/NF1/AKT3	5.27765778298095
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	7/110	125/9376	4.77323636363636	PTEN/FYN/PPP2R5E/GNAQ/ROCK1/AKT3/ROCK2	4.62711730871503
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	8/110	166/9376	4.10777656078861	MEF2A/ITPR2/PPP3CA/PDE3B/GNAQ/ROCK1/AKT3/ROCK2	4.40159265802973
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	6/110	93/9376	5.49912023460411	LAMA2/PTEN/ITGB1/RARB/AKT3/CDK6	4.75073418537925
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	9/110	212/9376	3.61852487135506	MAGI3/HGF/ITGB1/RAPGEF2/RAP1B/GNAQ/ANGPT1/FGF7/AKT3	4.20163117079473
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	12/110	362/9376	2.82551481667504	LAMA2/PTEN/GSK3B/HGF/ITGB1/JAK2/PPP2R5E/ANGPT1/FGF7/AKT3/CDK6/TNXB	3.85937254902543
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	5/110	67/9376	6.36092265943012	ITPR2/PPP3CA/RAP1B/GNAQ/RPS6KA3	4.79801123821985
Organismal Systems	Endocrine system	hsa04924	Renin secretion	5/110	69/9376	6.17654808959157	PDE1C/ITPR2/PPP3CA/PDE3B/GNAQ	4.70214236732675
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	8/110	184/9376	3.70592885375494	GSK3B/ITGB1/FYN/PPP3CA/NRP1/EPHA3/ROCK1/ROCK2	4.03883499065058
Human Diseases	Cancer: specific types	hsa05218	Melanoma	5/110	73/9376	5.83810709838107	PTEN/HGF/FGF7/AKT3/CDK6	4.52127819726119
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	7/110	148/9376	4.03144963144963	NCOA1/PTEN/GSK3B/FGF7/AKT3/CDK6/TCF7L1	4.05007675947404
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	6/110	110/9376	4.64925619834711	BMP5/BMP6/TGFBR2/SMAD5/ROCK1/DCN	4.19459835162605
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	7/110	150/9376	3.97769696969697	GSK3B/HGF/RARB/TGFBR2/FGF7/AKT3/TCF7L1	4.00548616668412
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	8/110	193/9376	3.53311351860575	GSK3B/ELMO1/JAK2/RAP1B/GNAQ/ROCK1/AKT3/ROCK2	3.87415371126781
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	8/110	196/9376	3.47903525046382	IL6ST/GSK3B/JAK2/ITPR2/PPP3CA/AKT3/CDK6/TCF7L1	3.8214240293993
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	7/110	157/9376	3.80034742327736	PTEN/ITPR2/PPP3CA/TGFBR2/HIPK3/AKT3/CDK6	3.85527770420464
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	9/110	248/9376	3.09325513196481	EXOC4/ELMO1/NAIP/NCKAP1/AKT3/ARHGEF26/ROCK2/TCF7L1/ABI1	3.63995506361341
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	8/110	204/9376	3.34260249554367	HGF/ITGB1/ITPR2/ROCK1/AKT3/DCN/LUM/ROCK2	3.68567888949774
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	6/110	122/9376	4.1919523099851	GSK3B/FYN/PPP3CA/PPP2R5E/CBLB/AKT3	3.86640545320042
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	7/110	170/9376	3.50973262032086	PTEN/GSK3B/HGF/TGFBR2/AKT3/CDK6/TCF7L1	3.59792630592954
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	6/110	133/9376	3.84524948735475	GSK3B/ITPR2/PPP3CA/PPP2R5E/GNAQ/AKT3	3.60060541735286
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	4/110	59/9376	5.77873651771957	PTEN/GSK3B/AKT3/TCF7L1	4.01177785441307
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	8/110	227/9376	3.00392470965158	GSK3B/ITPR2/PPP3CA/GNAQ/ROCK1/AKT3/CDK6/ROCK2	3.32999321086454
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	6/110	140/9376	3.65298701298701	MEF2A/ITPR2/PDE3B/GNAQ/APLN/AKT3	3.44582337364454
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	8/110	238/9376	2.86508785332315	HGF/NF1/RAP1B/ANGPT1/FGF7/AKT3/RALGAPA2/RASAL2	3.17539698580338
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	5/110	106/9376	4.02058319039451	PTEN/GSK3B/ZEB1/AKT3/TCF7L1	3.40753009060839
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	5/110	107/9376	3.98300764655905	ITPR2/PPP3CA/PDE3B/GNAQ/AKT3	3.38115941385985
NA	NA	hsa04517	IgSF CAM signaling	9/110	299/9376	2.56564305259957	MPDZ/GSK3B/ITGB1/FYN/RAPGEF2/NRP1/RAP1B/AKT3/APP	2.99773345339191
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	5/110	109/9376	3.90992493744787	IL6ST/JAK2/PPP3CA/TGFBR2/RORA	3.32936405675715
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	7/110	200/9376	2.98327272727273	ITGB1/FYN/NAIP/NCKAP1/ROCK1/ROCK2/ABI1	3.08891934110085
NA	NA	hsa04518	Integrin signaling	6/110	154/9376	3.32089728453365	LAMA2/GSK3B/HGF/ITGB1/AKT3/TNXB	3.16402243829991
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	6/110	154/9376	3.32089728453365	ITPR2/PPP3CA/GNAQ/ROCK1/MAP2K5/ROCK2	3.16402243829991
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	8/110	253/9376	2.69522098454905	GSK3B/ITGB1/ELMO1/NAIP/ITPR2/ROCK1/AKT3/ROCK2	2.9781980553668
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	6/110	155/9376	3.29947214076246	GSK3B/ITPR2/RAP1B/GNAQ/CDK6/TCF7L1	3.14514609161056
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	4/110	73/9376	4.67048567870486	HGF/RARB/AKT3/CDK6	3.43011978342539
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	5/110	115/9376	3.70592885375494	FYN/JAK2/ITPR2/GNAQ/AKT3	3.18106237214935
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	5/110	116/9376	3.67398119122257	GRIK2/GLS/ITPR2/PPP3CA/GNAQ	3.15731332314501
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	4/110	77/9376	4.42786304604486	MECOM/TGFBR2/AKT3/CDK6	3.29068668350839
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	5/110	120/9376	3.55151515151515	GSK3B/RAP1B/MAP2K5/AKT3/RPS6KA3	3.06487618470013
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	7/110	216/9376	2.76228956228956	GSK3B/JAK2/PPP3CA/MIB1/RAP1B/AKT3/ROCK2	2.85490880853267
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	5/110	122/9376	3.49329359165425	NCOA1/SLC16A10/GSK3B/MED13L/AKT3	3.02012154412378
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	5/110	122/9376	3.49329359165425	GSK3B/JAK2/ITPR2/GNAQ/AKT3	3.02012154412378
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	9/110	333/9376	2.3036855036855	LAMA2/PTEN/GSK3B/ITGB1/PPP2R5E/AKT3/CDK6/TNXB/TCF7L1	2.63921347915726
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	6/110	178/9376	2.87313585291113	GSK3B/MCC/PPP3CA/TBL1XR1/ROCK2/TCF7L1	2.74895992076699
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	4/110	87/9376	3.91891327063741	GSK3B/TGFBR2/AKT3/TCF7L1	2.98010913514757
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	7/110	232/9376	2.5717868338558	ITGB1/NCKAP1/ROCK1/C7/FGF7/AKT3/ROCK2	2.64122477991834
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	4/110	89/9376	3.83084780388151	ITPR2/GNAQ/MAP2K5/MAP3K2	2.92354399843834
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	4/110	90/9376	3.78828282828283	PTEN/JAK2/PPP3CA/AKT3	2.89587340209059
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	5/110	142/9376	3.00128040973111	FYN/ITPR2/PPP3CA/TGFBR2/AKT3	2.6181408932635
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	5/110	144/9376	2.95959595959596	IL6ST/GSK3B/JAK2/SMAD5/AKT3	2.58187799627058
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	7/110	254/9376	2.34903364352183	GNA14/PDE1C/HGF/ITPR2/PPP3CA/GNAQ/FGF7	2.3748185788502
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	6/110	201/9376	2.54436906377205	KDM6A/ZEB1/TGFBR2/RUNX1T1/JMJD1C/PROM1	2.41147030581143
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	4/110	103/9376	3.31015004413063	GNA14/TGFBR2/GNAQ/AKT3	2.56852917758114
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	4/110	105/9376	3.24709956709957	ITPR2/PPP3CA/CBLB/AKT3	2.52283883664129
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	8/110	323/9376	2.11111736560653	GLS/PTEN/ZFPM2/ZEB1/DICER1/ROCK1/CDK6/TNXB	2.21411803281953
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	5/110	157/9376	2.71453387376954	GSK3B/BMP5/BMP6/TGFBR2/TCF7L1	2.36042291099415
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	5/110	158/9376	2.69735327963176	GSK3B/NIPBL/PPP2R5E/CDK6/ATRX	2.34432742574088
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	4/110	109/9376	3.1279399499583	PTEN/GSK3B/AKT3/RPS6KA3	2.43466307091149
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	3/110	65/9376	3.93398601398601	ITPR2/GNAQ/AKT3	2.58614211705553
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	4/110	112/9376	3.04415584415584	LAMA2/ITGB1/JAK2/AKT3	2.37115297738487
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	3/110	68/9376	3.76042780748663	RUNX1T1/AKT3/TCF7L1	2.48907793865162
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	4/110	116/9376	2.93918495297806	ITGB1/RAP1B/ROCK1/ROCK2	2.2896999082034
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	3/110	70/9376	3.65298701298701	HGF/RAP1B/AKT3	2.42738381994064
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	3/110	70/9376	3.65298701298701	LAMA2/FYN/EIF4G3	2.42738381994064
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	5/110	170/9376	2.50695187165775	MPDZ/ITGB1/RAPGEF2/ROCK1/ROCK2	2.16035036438026
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	3/110	71/9376	3.60153649167734	GSK3B/JAK2/AKT3	2.39737924181022
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	3/110	71/9376	3.60153649167734	GLS/PTEN/AKT3	2.39737924181022
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	3/110	73/9376	3.50286425902864	BICD1/CPSF6/MDFIC	2.33896136958959
Human Diseases	Cancer: specific types	hsa05214	Glioma	3/110	76/9376	3.36459330143541	PTEN/AKT3/CDK6	2.2550574458076
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	3/110	77/9376	3.32089728453365	TGFBR2/AKT3/CDK6	2.22801952278046
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	4/110	128/9376	2.66363636363636	PAPSS2/ENPP1/PDE1C/PDE3B	2.06478725910353
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	3/110	78/9376	3.27832167832168	ITGB1/ELMO1/ARHGEF26	2.20142252450461
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	4/110	134/9376	2.54436906377205	ITPR2/GNAQ/ROCK1/ROCK2	1.96180728696107
Human Diseases	Infectious disease: viral	hsa05162	Measles	4/110	136/9376	2.50695187165775	GSK3B/CBLB/AKT3/CDK6	1.92871777817074
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	4/110	138/9376	2.47061923583663	ITPR2/PPP3CA/PPP2R5E/RPS6KA3	1.89621090293015
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	4/110	138/9376	2.47061923583663	GSK3B/PDE3B/CBLB/AKT3	1.89621090293015
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	3/110	86/9376	2.97336152219873	GSK3B/CBLB/AKT3	2.00301341191283
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	3/110	86/9376	2.97336152219873	LAMA2/ITGB1/TCF7L1	2.00301341191283
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	4/110	139/9376	2.45284499672989	NCOA1/ITPR2/GNAQ/AKT3	1.88016967306589
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	3/110	89/9376	2.87313585291113	LAMA2/ITGB1/TNXB	1.93447174147948
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	4/110	144/9376	2.36767676767677	ITPR2/GNAQ/AKT3/RORA	1.80199113760328
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	3/110	91/9376	2.80999000999001	GSK3B/PPP3CA/AKT3	1.89034795936852
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	3/110	93/9376	2.74956011730205	ITPR2/GNAQ/MAP3K2	1.84740452026936
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	4/110	149/9376	2.2882245271507	FYN/PLPP1/DGKH/AKT3	1.72699177977224
NA	NA	hsa04519	Cadherin signaling	8/110	404/9376	1.68784878487849	ERBIN/MPDZ/GSK3B/NCKAP1/ROCK1/CDH11/ROCK2/TCF7L1	1.53983737755746
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	3/110	98/9376	2.60927643784787	PTEN/ITPR2/DGKH	1.7448268641834
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	3/110	99/9376	2.58292011019284	PLPP1/DGKH/AKT3	1.72507764980206
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/110	10/9376	8.52363636363636	PAPSS2	2.59350179527877
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	4/110	158/9376	2.15788262370541	PTEN/GSK3B/AKT3/RPS6KA3	1.59922864798676
NA	NA	hsa04081	Hormone signaling	5/110	219/9376	1.94603569946036	GNA14/SLC16A10/JAK2/SMAD5/GNAQ	1.54343664888645
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	3/110	101/9376	2.53177317731773	GSK3B/GNAQ/TCF7L1	1.68629681979609
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	3/110	101/9376	2.53177317731773	JAK2/TGFBR2/AKT3	1.68629681979609
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	3/110	102/9376	2.50695187165775	ITPR2/RAP1B/GNAQ	1.66725395067587
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	3/110	103/9376	2.48261253309797	LAMA2/GNA14/GNAQ	1.64843558970765
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	5/110	224/9376	1.9025974025974	PTEN/PPP3CA/TGFBR2/NRP1/AKT3	1.48969004549825
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	5/110	226/9376	1.88576025744167	PDE3B/RAP1B/ROCK1/AKT3/ROCK2	1.46857352873117
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	4/110	169/9376	2.01742872512103	WDFY3/PTEN/UVRAG/AKT3	1.45419989351036
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	3/110	110/9376	2.32462809917355	PDE3B/AKT3/RPS6KA3	1.52257954479261
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2/110	59/9376	2.88936825885978	PDE3B/AKT3	1.58613594024676
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	3/110	115/9376	2.22355731225296	ITPR2/GNAQ/APP	1.43840150149365
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	3/110	115/9376	2.22355731225296	MEF2A/ITPR2/GNAQ	1.43840150149365
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	2/110	60/9376	2.84121212121212	PPP3CA/AKT3	1.55883641822528
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/110	60/9376	2.84121212121212	ITPR2/GNAQ	1.55883641822528
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/110	63/9376	2.70591630591631	GSK3B/TCF7L1	1.48019531914325
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	5/110	250/9376	1.70472727272727	TGFBR2/ACAP2/EPS15/CBLB/PSD3	1.23051435319656
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	4/110	187/9376	1.823237724842	ERBIN/NAIP/ANTXR2/ITPR2	1.23893286649515
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	2/110	65/9376	2.62265734265734	PLPP1/DGKH	1.43028033378197
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	2/110	65/9376	2.62265734265734	ITPR2/GNAQ	1.43028033378197
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/110	17/9376	5.01390374331551	PAPSS2	1.80473118753907
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/110	17/9376	5.01390374331551	CA8	1.80473118753907
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	2/110	69/9376	2.47061923583663	FYN/AKT3	1.33584405966152
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	2/110	70/9376	2.43532467532468	JAK2/AKT3	1.31326835607911
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	3/110	133/9376	1.92262474367738	PTEN/TGFBR2/AKT3	1.167562867521
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	2/110	75/9376	2.2729696969697	REV3L/AKT3	1.20592335937243
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	2/110	75/9376	2.2729696969697	PTEN/CDK6	1.20592335937243
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	2/110	75/9376	2.2729696969697	ITPR2/GNAQ	1.20592335937243
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/110	21/9376	4.05887445887446	ENPP1	1.52892167483941
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	4/110	205/9376	1.66314855875831	PTEN/GSK3B/TGFBR2/AKT3	1.04596041028023
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	5/110	275/9376	1.5497520661157	GSK3B/FYN/ITPR2/PPP3CA/C7	1.00814846408249
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	2/110	76/9376	2.24306220095694	ITPR2/GNAQ	1.1854794099976
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	3/110	142/9376	1.80076824583867	MEF2A/MAP2K5/AKT3	1.04759137213499
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	2/110	78/9376	2.18554778554779	CNOT2/CNOT6L	1.14553253116743
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	2/110	78/9376	2.18554778554779	ITGB1/JAK2	1.14553253116743
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	2/110	79/9376	2.15788262370541	SYT1/NSF	1.12601065359482
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/110	23/9376	3.70592885375494	GLS	1.4156003368476
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/110	23/9376	3.70592885375494	GLS	1.4156003368476
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	3/110	144/9376	1.77575757575758	GSK3B/AKT3/TCF7L1	1.02210427893598
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	4/110	214/9376	1.59320305862362	ITPR2/PPP3CA/GNAQ/AKT3	0.956425083280285
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	4/110	217/9376	1.57117720988689	JAK2/FGF7/AKT3/RPS6KA3	0.927497058425759
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	3/110	154/9376	1.66044864226682	PPP2R5E/GNAQ/AKT3	0.900373462196037
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/110	27/9376	3.15690235690236	HMGCLL1	1.22282869128617
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/110	27/9376	3.15690235690236	HSD17B12	1.22282869128617
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	3/110	156/9376	1.63916083916084	GSK3B/AKT3/CDK6	0.877087314508185
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	2/110	89/9376	1.91542390194076	GLS/NSF	0.945399484520617
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/110	28/9376	3.04415584415584	HSD17B12	1.18023774466725
Human Diseases	Substance dependence	hsa05032	Morphine addiction	2/110	91/9376	1.87332667332667	PDE1C/PDE3B	0.912099672193377
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	4/110	233/9376	1.46328521264144	LAMA2/ITGB1/PDLIM5/DCN	0.780221424906001
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	2/110	93/9376	1.83304007820137	JAK2/PPP3CA	0.879627965232737
Organismal Systems	Digestive system	hsa04970	Salivary secretion	2/110	93/9376	1.83304007820137	ITPR2/GNAQ	0.879627965232737
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	3/110	163/9376	1.56876742889013	JAK2/TGFBR2/AKT3	0.798111957457002
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	6/110	388/9376	1.31808809746954	GSK3B/ITPR2/PPP3CA/GNAQ/AKT3/APP	0.697216381130162
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	3/110	168/9376	1.52207792207792	IL6ST/JAK2/AKT3	0.743948969114935
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	2/110	98/9376	1.73951762523191	PLPP1/AKT3	0.801807687414691
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	2/110	98/9376	1.73951762523191	ITPR2/GNAQ	0.801807687414691
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	2/110	99/9376	1.72194674012856	ITPR2/GNAQ	0.786782717411755
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	2/110	99/9376	1.72194674012856	LAMA2/ITGB1	0.786782717411755
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/110	34/9376	2.50695187165775	RORA	0.959079795776242
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	3/110	173/9376	1.47808723068839	JAK2/AKT3/CDK6	0.691514542310614
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	2/110	103/9376	1.65507502206531	CPSF6/PPP2R5E	0.728342001834158
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	2/110	103/9376	1.65507502206531	SLC16A10/COL15A1	0.728342001834158
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	2/110	104/9376	1.63916083916084	PLPP1/DGKH	0.714127815461799
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/110	36/9376	2.36767676767677	ENPP1	0.895771240351504
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	2/110	105/9376	1.62354978354978	LAMA2/ITGB1	0.700064934171632
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/110	37/9376	2.3036855036855	GLS	0.865683906021256
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/110	37/9376	2.3036855036855	GNAQ	0.865683906021256
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	1/110	37/9376	2.3036855036855	TCF7L1	0.865683906021256
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	3/110	181/9376	1.41275740833752	JAK2/PPP3CA/AKT3	0.610933767912968
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/110	38/9376	2.24306220095694	ENPP1	0.836553184898411
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	2/110	110/9376	1.5497520661157	ANGPT1/AKT3	0.631906609181459
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	1/110	41/9376	2.07893569844789	BABAM2	0.754338307087987
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/110	43/9376	1.98224101479915	PLPP1	0.703359718263888
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	1/110	44/9376	1.93719008264463	MAN1A1	0.678894812604073
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	1/110	44/9376	1.93719008264463	NSF	0.678894812604073
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	1/110	46/9376	1.85296442687747	PSME4	0.631836696870037
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	2/110	122/9376	1.3973174366617	PPP2R5E/AKT3	0.481269816893843
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/110	48/9376	1.77575757575758	HMGCLL1	0.587067729418981
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/110	48/9376	1.77575757575758	AKT3	0.587067729418981
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	1/110	50/9376	1.70472727272727	HGF	0.544370031252178
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	2/110	130/9376	1.31132867132867	TGFBR2/AKT3	0.389448183626782
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	1/110	51/9376	1.67130124777184	PLPP1	0.523737842792995
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	1/110	52/9376	1.63916083916084	BMP6	0.503554556960943
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	2/110	133/9376	1.28174982911825	FYN/PPP3CA	0.356548684243706
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	4/110	298/9376	1.14411226357535	IL6ST/BMP5/BMP6/TGFBR2	0.2754544642969
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	1/110	53/9376	1.6082332761578	GNAQ	0.483800265147029
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/110	54/9376	1.57845117845118	REV3L	0.464456316581101
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	1/110	55/9376	1.5497520661157	PLPP1	0.445505216707298
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	2/110	137/9376	1.24432647644326	ITPR2/AKT3	0.313873149110564
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	1/110	56/9376	1.52207792207792	MAN1A1	0.426930535475036
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	1/110	56/9376	1.52207792207792	GSK3B	0.426930535475036
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	1/110	56/9376	1.52207792207792	NAIP	0.426930535475036
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/110	57/9376	1.49537480063796	HSD17B12	0.408716824418533
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	3/110	227/9376	1.12647176611934	PTEN/HGF/AKT3	0.210162647586039
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/110	59/9376	1.44468412942989	ENPP1	0.373314983163607
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	1/110	62/9376	1.37478005865103	AKT3	0.322581929754048
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	2/110	149/9376	1.14411226357535	ITPR2/GNAQ	0.193196674425596
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	1/110	63/9376	1.35295815295815	MECOM	0.306255942363761
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	3/110	238/9376	1.07440794499618	IL6ST/NRP1/C7	0.126682914072765
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/110	66/9376	1.29146005509642	HSD17B12	0.258888049086495
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	1/110	66/9376	1.29146005509642	RORA	0.258888049086495
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	2/110	157/9376	1.08581354950782	ELMO1/JAK2	0.118140721178431
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	2/110	157/9376	1.08581354950782	GSK3B/AKT3	0.118140721178431
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	1/110	69/9376	1.23530961791831	PPP3CA	0.213744623773112
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	1/110	78/9376	1.09277389277389	PTEN	0.089642537830247
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	1/110	78/9376	1.09277389277389	ITGB1	0.089642537830247
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	1/110	83/9376	1.02694414019715	HMGCLL1	0.026863416155912
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	2/110	180/9376	0.947070707070707	JAK2/AKT3	-0.0781211623563466
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	1/110	85/9376	1.0027807486631	ENPP1	0.00280592334755928
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/110	86/9376	0.991120507399577	PDE1C	-0.00901291657385252
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	1/110	86/9376	0.991120507399577	GNAQ	-0.00901291657385252
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	1/110	88/9376	0.968595041322314	C7	-0.0322488544278942
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	1/110	90/9376	0.947070707070707	AKT3	-0.0549716585529441
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	5/110	480/9376	0.887878787878788	GSK3B/ITPR2/PPP3CA/GNAQ/APP	-0.274755787096872
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	1/110	94/9376	0.906769825918762	GSK3B	-0.0989772704234361
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	1/110	95/9376	0.897224880382775	ANGPT1	-0.109695355532685
NA	NA	hsa04082	Neuroactive ligand signaling	2/110	199/9376	0.856646870717222	GRIK2/GNAQ	-0.222699469701788
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	1/110	97/9376	0.878725398313027	GNAQ	-0.130810007187927
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	1/110	99/9376	0.860973370064279	AKT3	-0.151512214978555
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	1/110	100/9376	0.852363636363636	IL6ST	-0.161714440531368
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	2/110	205/9376	0.831574279379157	AKT3/CDK6	-0.265651841530314
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	2/110	205/9376	0.831574279379157	IL6ST/CDK6	-0.265651841530314
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	1/110	105/9376	0.811774891774892	MTX2	-0.211322017063195
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	1/110	109/9376	0.781984987489575	AKT3	-0.249439886625485
NA	NA	hsa04382	Cornified envelope formation	2/110	217/9376	0.785588604943444	DST/PPP2R5E	-0.348168545182854
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	1/110	117/9376	0.728515928515929	EPC1	-0.321951961519783
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	1/110	119/9376	0.716271963330787	AKT3	-0.339372333423005
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	2/110	235/9376	0.72541586073501	KDM3B/RPS6KA3	-0.464460041977764
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	3/110	370/9376	0.691105651105651	GRIK2/NR3C1/APLN	-0.660511961249516
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	1/110	142/9376	0.600256081946223	CBLB	-0.522958148993515
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	1/110	143/9376	0.596058486967578	C7	-0.530335771631533
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	1/110	155/9376	0.549912023460411	ITGB1	-0.615616260445325
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	1/110	160/9376	0.532727272727273	ITGB1	-0.64952373382383
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	1/110	168/9376	0.507359307359307	JAK2	-0.702001597722053
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	1/110	174/9376	0.489864158829676	MAN1A1	-0.740039975040979
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	1/110	195/9376	0.437109557109557	AKT3	-0.865430147364804
Genetic Information Processing	Transcription	hsa03040	Spliceosome	1/110	243/9376	0.350766928544706	DHX15	-1.11720501152827
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	1/110	268/9376	0.318046132971506	ITPR2	-1.23408966499136
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	1/110	308/9376	0.276741440377804	GNAQ	-1.40620622942916
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	1/110	368/9376	0.231620553359684	PPP3CA	-1.63840510633996
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/110	449/9376	0.189835999190119	PDE1C	-1.91681049066622