category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	27/473	142/9376	3.76904981687163	PIAS1/COP1/UBE2H/NEDD4/UBE2E2/UBE3A/FBXW7/HERC4/FBXW11/MAP3K1/UBR5/MDM2/NEDD4L/SKP2/SMURF1/UBE2R2/UBE4B/ANAPC10/TRIP12/WWP1/CUL3/UBE2D2/ITCH/UBE2K/CUL5/BIRC6/BTRC	7.66351528594559
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	34/473	232/9376	2.90500838375738	PDGFD/DIAPH2/VAV3/ITGB8/RRAS2/MYH10/FGFR2/PDGFC/PIK3CA/PPP1R12B/SSH2/ITGAV/ITGA6/PIP5K1B/WASL/AKT3/PIK3R1/ROCK2/SCIN/GNA12/DIAPH3/DOCK1/MAP2K1/PPP1R12A/ROCK1/GNG12/NCKAP1/PIKFYVE/PTK2/ENAH/GNA13/ITGB1/KRAS/ITGB6	6.77205999473341
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	30/473	203/9376	2.92942021891501	PDGFD/VAV3/ARHGAP5/IGF1R/ITGB8/MAPK8/GSK3B/PDGFC/MET/PIK3CA/PPP1R12B/LAMB1/ITGAV/ITGA6/LAMC1/PIP5K1B/AKT3/PIK3R1/ROCK2/RAP1B/DOCK1/MAP2K1/PPP1R12A/ROCK1/PTK2/PTEN/ITGB1/CTNNB1/ITGB6/GRB2	6.40570846660508
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	26/473	169/9376	3.04960156122947	WDFY3/IGF1R/UVRAG/RRAS2/MAPK8/ATG5/ATG10/STX17/MTMR3/PIK3CA/STX7/SUPT20H/C9orf72/AKT3/PIK3R1/ATG4C/EIF2AK4/VPS41/MAP2K1/OPTN/ATG2B/PTEN/ULK2/BIRC6/PRKACB/KRAS	6.1972889517772
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	27/473	184/9376	2.90872322823789	RASA1/SRGAP1/SEMA6D/SEMA6A/PPP3CA/PARD3/GSK3B/MET/PIK3CA/SSH2/SEMA3C/PPP3CB/PIK3R1/ROCK2/GNAI1/NRP1/EFNA5/NTN4/NCK1/ROCK1/PTK2/ENAH/ABL1/ITGB1/BMP7/SEMA4D/KRAS	6.02691247088524
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	21/473	122/9376	3.41205420580182	MAPK8/MAP2K4/GSK3B/MAP3K1/ATF2/PIK3CA/AKT3/GNAQ/PIK3R1/ITPR2/GNAI1/MAP2K1/MAPK14/ADCY2/PTK2/CREB1/CREBBP/PRKACB/KRAS/EP300/GRB2	6.18087916158485
NA	NA	hsa04517	IgSF CAM signaling	36/473	299/9376	2.38664470009263	RASA1/RAPGEF2/VAV3/SRGAP1/EPB41L3/IL1RAPL2/LMO7/ERC1/PRKCI/MAPK8/MYH10/PARD3/CD2AP/TRIO/GSK3B/PIK3CA/CADM1/WASL/AKT3/PIK3R1/GRIP1/APP/NRP1/RAP1B/MAP2K1/CDH1/NCK1/MAPK14/NRCAM/PTK2/ABL1/ITGB1/MTSS1/CNTNAP2/CTNNB1/GRB2	5.61665365500186
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	28/473	204/9376	2.72072296148904	VAV3/IGF1R/FRS2/RRAS2/GAB1/ERBB4/MET/PIK3CA/PPP1R12B/MDM2/ITGAV/AKT3/PIK3R1/ITPR2/ROCK2/SMAD2/PDCD4/GPC1/MAP2K1/PPP1R12A/MAPK14/ROCK1/PTK2/ITGB1/PRKACB/KRAS/CTNNB1/GRB2	5.72719587453821
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	35/473	300/9376	2.31261451726568	PDGFD/RASA1/RAPGEF2/IGF1R/MAP4K3/CACNA2D3/RRAS2/PPP3CA/MAPK8/MAP2K4/FGFR2/ERBB4/PDGFC/NF1/MET/MAP3K1/ATF2/RASA2/MAP3K20/STK3/AKT3/PPP3CB/GNA12/RAP1B/EFNA5/MAP2K1/MAPK14/MAP2K5/GNG12/NLK/MAP4K4/TAB2/PRKACB/KRAS/GRB2	5.32596868743261
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	16/473	83/9376	3.82118749840801	MBD5/JARID2/TEX10/YAF2/SUZ12/ASXL1/LCOR/SCMH1/UBE2D2/MGA/CREBBP/ASXL2/SFMBT2/OGT/MTF2/EP300	5.95032997520321
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	17/473	93/9376	3.6234513173748	IGF1R/FER/LMO7/PARD3/TCF7L2/MET/WASL/SMURF1/ROCK2/RAP1B/CDH1/ROCK1/CTNNA1/CREBBP/NLK/CTNNB1/EP300	5.86027950975568
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	29/473	227/9376	2.53237838895046	CDK6/AKAP13/PPP3CA/GSK3B/ATF2/PIK3CA/MDM2/ITGAV/AKT3/GNAQ/PPP3CB/PIK3R1/ITPR2/ROCK2/GNAI1/GNA12/MAP2K1/CCR3/MAPK14/ADCY2/ROCK1/GNG12/PTK2/CREB1/GNA13/PRKACB/KRAS/CTNNB1/GRB2	5.38691540094762
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	23/473	157/9376	2.90391995798602	CDK6/RRAS2/PPP3CA/TRPM7/ATM/FBXW11/PIK3CA/MDM2/AKT3/PPP3CB/MRE11/PIK3R1/ITPR2/SMAD2/LIN9/MAP2K1/LIN52/MAPK14/PTEN/ATR/LIN54/BTRC/KRAS	5.54503928071724
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	37/473	333/9376	2.2024900164435	PATJ/CDK6/ITGB8/MAML3/UBR4/PRKCI/UBE3A/PARD3/ATM/GSK3B/TCF7L2/RBPJ/PIK3CA/MDM2/LAMB1/ITGAV/ITGA6/LAMC1/PPP2R2A/AKT3/CSNK1A1/PIK3R1/MAP2K1/PTK2/CREB1/PTEN/ATP6V1H/CREBBP/ITGB1/ATR/DLG1/PRKACB/KRAS/CTNNB1/ITGB6/EP300/GRB2	5.14985916720451
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	18/473	106/9376	3.36606964777215	PDGFD/IGF1R/FGFR2/GSK3B/PDGFC/TCF7L2/PIK3CA/MDM2/AKT3/PIK3R1/MAP2K1/CREB1/PTEN/CREBBP/KRAS/CTNNB1/EP300/GRB2	5.64662064736713
NA	NA	hsa04518	Integrin signaling	22/473	154/9376	2.83177287828451	PDGFD/FRAS1/IGF1R/ITGB8/GSK3B/PDGFC/FREM2/MET/PIK3CA/LAMB1/ITGAV/ITGA6/LAMC1/FBN1/AKT3/PIK3R1/CDH1/PTK2/FERMT2/ITGB1/CTNNB1/ITGB6	5.28283988183199
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	15/473	80/9376	3.71670190274841	PDGFD/IGF1R/FGFR2/GAB1/GSK3B/PDGFC/NF1/MET/PIK3CA/AKT3/PIK3R1/MAP2K1/PTEN/KRAS/GRB2	5.62453915934617
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	22/473	157/9376	2.77766256850837	PATJ/FRMD6/RASSF6/PRKCI/YAP1/PARD3/GSK3B/TEAD1/TCF7L2/FBXW11/BMPR1A/STK3/PPP2R2A/LATS2/SMAD2/CDH1/AMOT/CTNNA1/DLG1/BMP7/BTRC/CTNNB1	5.17732309538192
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	23/473	178/9376	2.56132265957194	LGR5/RNF43/TLE4/PPP3CA/MAPK8/GSK3B/TCF7L2/FBXW11/TBL1XR1/ROR2/PPP3CB/CSNK1A1/ZNRF3/ROCK2/INVS/TBL1X/CREBBP/NLK/LGR4/PRKACB/BTRC/CTNNB1/EP300	4.84734558327292
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	12/473	59/9376	4.03167664026947	GSK3B/TCF7L2/PIK3CA/AKT3/PIK3R1/MAP2K1/CDH1/CTNNA1/PTEN/KRAS/CTNNB1/GRB2	5.3841711593738
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	21/473	158/9376	2.63462413359381	CDK6/NIPBL/ATM/GSK3B/MDM2/SKP2/CCNH/STAG1/WAPL/ESCO1/STAG2/SMAD2/ATRX/ANAPC10/TFDP2/ABL1/ORC3/CREBBP/ATR/PDS5B/EP300	4.77612978895299
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	19/473	138/9376	2.72917241168	VAV3/PKN2/MAPK8/MAP2K4/GSK3B/PIK3CA/PIP5K1B/WASL/AKT3/GNAQ/PIK3R1/ROCK2/DOCK1/MAP2K1/MAPK14/ROCK1/PTK2/ITGB1/TAB2	4.71668511755356
Human Diseases	Cancer: specific types	hsa05218	Melanoma	13/473	73/9376	3.53001824553274	PDGFD/CDK6/IGF1R/PDGFC/MET/PIK3CA/MDM2/AKT3/PIK3R1/MAP2K1/CDH1/PTEN/KRAS	5.00174555222785
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	25/473	212/9376	2.33754836650844	PDGFD/RAPGEF2/VAV3/IGF1R/MAGI3/PRKCI/PARD3/FGFR2/PDGFC/MET/PIK3CA/AKT3/GNAQ/PIK3R1/GNAI1/RAP1B/EFNA5/MAP2K1/CDH1/MAPK14/ADCY2/ENAH/ITGB1/KRAS/CTNNB1	4.54028282985349
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	27/473	238/9376	2.24876081510828	PDGFD/RASA1/IGF1R/RRAS2/MAPK8/FGFR2/GAB1/PDGFC/NF1/MET/PIK3CA/RASA2/RASAL2/AKT3/PIK3R1/RALGAPA2/RAP1B/EFNA5/SHOC2/MAP2K1/GNG12/RGL1/ABL1/EXOC2/PRKACB/KRAS/GRB2	4.49769691160906
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	11/473	56/9376	3.8936877076412	GLI3/LRP2/GSK3B/FBXW11/SMURF1/CSNK1A1/CUL3/SPOPL/HHAT/PRKACB/BTRC	5.00594113729626
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	14/473	86/9376	3.22690397758002	MAPK8/MAP2K4/GAB1/ERBB4/GSK3B/PIK3CA/AKT3/PIK3R1/MAP2K1/NCK1/PTK2/ABL1/KRAS/GRB2	4.7817942063918
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	19/473	144/9376	2.61545689452666	IGF1R/SMARCAD1/JARID2/IL6ST/FGFR2/GSK3B/PIK3CA/BMPR1A/AKT3/RIF1/PIK3R1/SMAD2/MAP2K1/MAPK14/ZFHX3/ACVR2A/KRAS/CTNNB1/GRB2	4.50273869157889
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	15/473	99/9376	3.00339547696842	IGF1R/MAPK8/NCOA3/ESR2/PIK3CA/MDM2/AKT3/PIK3R1/MAP2K1/MAPK14/ADCY2/PTK2/PRKACB/KRAS/GRB2	4.61879332832729
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	17/473	122/9376	2.76213911898243	NCOA1/NCOA3/GSK3B/PIK3CA/MDM2/NCOA2/ITGAV/AKT3/MED13L/PIK3R1/MAP2K1/CREBBP/MED13/PRKACB/KRAS/CTNNB1/EP300	4.51547437621177
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	13/473	78/9376	3.30373502466526	CD2AP/GAB1/ARHGAP10/MET/PIK3CA/WASL/PIK3R1/DOCK1/CDH1/CTNNA1/PTK2/ITGB1/CTNNB1	4.70904756773623
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	17/473	125/9376	2.69584778012685	MAPK8/PIK3CA/PPP2R2A/AKT3/GNAQ/PIK3R1/ROCK2/GNAI1/GNA12/MAP2K1/SGMS1/MAPK14/ROCK1/PTEN/GNA13/CERS6/KRAS	4.39942132047884
Organismal Systems	Immune system	hsa04611	Platelet activation	17/473	126/9376	2.67445216282426	PRKCI/PIK3CA/AKT3/GNAQ/PIK3R1/ITPR2/ROCK2/GNAI1/RAP1B/PPP1R12A/MAPK14/ADCY2/ROCK1/GNA13/ITGB1/PRKG1/PRKACB	4.36149293009349
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	20/473	166/9376	2.38824218650501	ATP2B1/PPP3CA/ATF2/PDE3B/AKT3/GNAQ/PPP3CB/ITPR2/ROCK2/GNAI1/GNA12/MAP2K1/PPP1R12A/ADCY2/ROCK1/EDNRB/CREB1/GNA13/PRKG1/MEF2A	4.15946513733242
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	17/473	130/9376	2.59216132704505	MAPK8/MAP2K4/ATF2/PIK3CA/AKT3/PIK3R1/GNAI1/SMAD2/MAP2K1/MAPK14/ADCY2/GNG12/EDNRB/CREB1/PRKACB/KRAS/GRB2	4.21337218951778
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	15/473	107/9376	2.77884254411096	PHKB/PPP3CA/ACACA/ATF2/PDE3B/AKT3/GNAQ/PPP3CB/ITPR2/ADCY2/CREB1/CREBBP/PRKACB/EP300/PPP4R3B	4.26541191186473
NA	NA	hsa04519	Cadherin signaling	37/473	404/9376	1.81541875117744	RERE/VAV3/TMC1/IGF1R/RRAS2/MYO1D/MAPK8/YAP1/GSK3B/TEAD1/TCF7L2/DSC3/MET/ERBIN/LIMA1/STK3/LATS2/CSNK1A1/ROCK2/PCDH11X/SHOC2/MAP2K1/GABRB1/CDH1/MAPK14/DSG2/ROCK1/NCKAP1/CTNNA1/PTK2/ENAH/CREBBP/KRAS/CTNNB1/ADAM10/EP300/GABRA4	3.86166651318279
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	13/473	86/9376	2.9964108363243	ITGB8/DMD/SNTB1/CACNA2D3/TCF7L2/ITGAV/ITGA6/SGCE/DSG2/CTNNA1/ITGB1/CTNNB1/ITGB6	4.28686008324772
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	20/473	170/9376	2.33204825270489	CDK6/IGF1R/ARID1B/NFE2L2/GAB1/GSK3B/TCF7L2/MET/PIK3CA/ARID2/SMARCA2/AKT3/CSNK1A1/PIK3R1/SMAD2/MAP2K1/PTEN/KRAS/CTNNB1/GRB2	4.03977292791356
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	17/473	133/9376	2.53369152267561	HOMER1/IGF1R/MAPK8/ATM/PIK3CA/MDM2/SKP2/AKT3/PIK3R1/MAP2K1/MAPK14/PTEN/CREBBP/NLK/KRAS/EP300/GRB2	4.10587178004527
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	15/473	110/9376	2.70305592927157	IGF1R/MAPK8/SPDYE5/CPEB2/PIK3CA/PDE3B/AKT3/PIK3R1/GNAI1/ANAPC10/MAP2K1/MAPK14/ADCY2/PRKACB/KRAS	4.14120879025929
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	17/473	139/9376	2.42432354327954	NCOA1/NCOA3/ESR2/ATF2/PIK3CA/NCOA2/AKT3/GNAQ/PIK3R1/ITPR2/GNAI1/MAP2K1/ADCY2/CREB1/PRKACB/KRAS/GRB2	3.89940732519584
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	11/473	70/9376	3.11495016611296	GAB1/MET/PIK3CA/AKT3/PIK3R1/RAP1B/MAP2K1/CREBBP/KRAS/EP300/GRB2	4.09369663994792
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	13/473	93/9376	2.77087453681602	CDK6/FHIT/PIK3CA/LAMB1/ITGAV/ITGA6/LAMC1/SKP2/AKT3/PIK3R1/PTK2/PTEN/ITGB1	3.95578896155609
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	21/473	196/9376	2.12382965871338	CDK6/PPP3CA/MAPK8/IL6ST/MAP2K4/GSK3B/TCF7L2/PIK3CA/AKT3/PPP3CB/PIK3R1/ITPR2/MAP2K1/CCR3/MAPK14/GNG12/CREB1/CREBBP/KRAS/CTNNB1/EP300	3.66484158067338
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	23/473	224/9376	2.03533675626699	PPP3CA/MAPK8/MAP2K4/ATM/MAP3K1/ATF2/PIK3CA/AKT3/PPP3CB/PIK3R1/SMAD2/NRP1/ANAPC10/MAP2K1/ADCY2/CREB1/PTEN/CREBBP/ATR/DLG1/PRKACB/KRAS/EP300	3.61489475643145
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	15/473	120/9376	2.47780126849894	FRS2/MAPK8/GAB1/GSK3B/MAP3K1/PIK3CA/AKT3/PIK3R1/RAP1B/MAP2K1/MAPK14/MAP2K5/ABL1/KRAS/GRB2	3.75528590290977
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	22/473	214/9376	2.03781786568137	TRIM5/PPP3CA/MAPK8/ATM/FBXW11/PIK3CA/AKT3/GNAQ/PPP3CB/PIK3R1/ITPR2/GNAI1/MAP2K1/MAPK14/GNG12/PTK2/ATR/CUL5/TAB2/AP1G1/BTRC/KRAS	3.53981778948965
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	15/473	122/9376	2.43718157557273	VAV3/PPP3CA/MAPK8/GSK3B/PIK3CA/PPP2R2A/AKT3/PPP3CB/PIK3R1/MAP2K1/NCK1/MAPK14/DLG1/KRAS/GRB2	3.68277198352524
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	21/473	205/9376	2.03058835662352	CDK6/UBR4/IL6ST/UBE3A/RBPJ/ATF2/PIK3CA/MDM2/RASA2/SKP2/PIK3R1/SCIN/SND1/CCR3/CREB1/CREBBP/DLG1/PRKACB/KRAS/EP300/GRB2	3.43875976981847
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	12/473	89/9376	2.67268451433594	PDGFD/PDGFC/GNAQ/ITPR2/GNAI1/MAP2K1/MAP2K5/ADCY2/PRKG1/PRKACB/KRAS/GRB2	3.65442740161647
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	13/473	101/9376	2.55139932597911	GSK3B/TCF7L2/GNAQ/GNAI1/MAP2K1/ADCY2/EDNRB/CREB1/CREBBP/PRKACB/KRAS/CTNNB1/EP300	3.61306145046456
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	10/473	67/9376	2.95856867880471	PPP3CA/GNAQ/PPP3CB/ITPR2/RAP1B/MAP2K1/CREBBP/PRKACB/KRAS/EP300	3.70828165875034
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	14/473	115/9376	2.4131629745381	PDE4B/AKAP13/ATF2/WNK1/GNAQ/ITPR2/GNAI1/GNA12/MAP2K1/ADCY2/CREB1/GNA13/PRKACB/MEF2A	3.5144733154457
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	7/473	37/9376	3.75018570367408	PPARG/TCF7L2/MAP2K1/CDH1/TFG/KRAS/CTNNB1	3.86332030221384
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	10/473	69/9376	2.87281306492631	VAV3/MAPK8/MAP2K4/PIK3CA/AKT3/PIK3R1/MAP2K1/MAPK14/KRAS/GRB2	3.5988367001725
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	22/473	226/9376	1.92961514714962	PDE4B/VAV3/GLI3/ATP2B1/PDE10A/RRAS2/MAPK8/PIK3CA/PDE3B/AKT3/PIK3R1/ROCK2/GNAI1/RAP1B/MAP2K1/PPP1R12A/ADCY2/ROCK1/CREB1/CREBBP/PRKACB/EP300	3.26058019225779
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	31/473	362/9376	1.69749921156834	PDGFD/CDK6/IGF1R/PKN2/ITGB8/FGFR2/ERBB4/GSK3B/PDGFC/MET/ATF2/PIK3CA/MDM2/PHLPP1/LAMB1/ITGAV/ITGA6/LAMC1/PPP2R2A/AKT3/PIK3R1/EFNA5/MAP2K1/GNG12/PTK2/CREB1/PTEN/ITGB1/KRAS/ITGB6/GRB2	3.11951624309814
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	10/473	71/9376	2.79188875323825	MAPK8/ESR2/GSK3B/PIK3CA/AKT3/PIK3R1/MAP2K1/MAPK14/KRAS/GRB2	3.49325308398938
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	6/473	29/9376	4.10118830648101	FRMD6/RASSF6/YAP1/TEAD1/STK3/LATS2	3.85513008522747
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	9/473	60/9376	2.97336152219873	PPP3CA/PIK3CA/AKT3/PPP3CB/PIK3R1/MAP2K1/MAPK14/PTK2/KRAS	3.53439889665747
Organismal Systems	Nervous system	hsa04730	Long-term depression	9/473	60/9376	2.97336152219873	IGF1R/GNAQ/ITPR2/GNAI1/GNA12/MAP2K1/GNA13/PRKG1/KRAS	3.53439889665747
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	21/473	216/9376	1.92717876438807	VAV3/PPARG/MIB1/PPP3CA/MAPK8/NFE2L2/MAP2K4/GSK3B/ABCA1/PIK3CA/AKT3/PPP3CB/PIK3R1/ROCK2/RAP1B/OLR1/MAPK14/POU2F1/PTK2/TAB2/KRAS	3.17753715040217
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	16/473	148/9376	2.14296325924233	CDK6/IGF1R/NCOA1/NCOA3/ESR2/GSK3B/TCF7L2/PIK3CA/AKT3/CSNK1A1/PIK3R1/MAP2K1/PTEN/KRAS/CTNNB1/GRB2	3.23040784887472
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	10/473	73/9376	2.7153986504098	EML4/CDK6/FHIT/MET/PIK3CA/AKT3/PIK3R1/MAP2K1/KRAS/GRB2	3.39127497801037
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	16/473	150/9376	2.11439041578576	FGFR2/GAB1/GSK3B/TCF7L2/MET/PIK3CA/AKT3/CSNK1A1/PIK3R1/SMAD2/MAP2K1/CDH1/CTNNA1/KRAS/CTNNB1/GRB2	3.17120483235691
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	19/473	193/9376	1.95142897829969	VAV3/PARD3/GSK3B/PIK3CA/AKT3/GNAQ/PIK3R1/ROCK2/GNAI1/RAP1B/MAP2K1/CCR3/ADCY2/ROCK1/GNG12/PTK2/PRKACB/KRAS/GRB2	3.07829870129379
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	12/473	99/9376	2.40271638157473	PDGFD/MAPK8/DGKD/PDGFC/SLC44A5/PIK3CA/PIP5K1B/AKT3/PIK3R1/MAP2K1/KRAS/GRB2	3.23393815112168
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	11/473	87/9376	2.50628174284951	MAPK8/GSK3B/TCF7L2/PIK3CA/AKT3/PIK3R1/SMAD2/MAP2K1/KRAS/CTNNB1/GRB2	3.25333944596464
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	23/473	253/9376	1.80203728618105	NAIP/MAPK8/ATG5/ATM/GSK3B/FBXW11/FNBP1L/PIK3CA/MDM2/WASL/AKT3/PIK3R1/ITPR2/ROCK2/DOCK1/MAPK14/ROCK1/CAST/UBE2D2/PTK2/ITGB1/TAB2/BTRC	2.98080800496561
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	15/473	140/9376	2.12382965871338	RRAS2/PDE3B/AKT3/GNAQ/ITPR2/GNAI1/SMAD2/MAP2K1/CDH1/ADCY2/GNG12/GNA13/PRKACB/KRAS/MEF2A	3.08795218448971
Human Diseases	Cancer: specific types	hsa05214	Glioma	10/473	76/9376	2.60821186157783	CDK6/IGF1R/PIK3CA/MDM2/AKT3/PIK3R1/MAP2K1/PTEN/KRAS/GRB2	3.24456593917016
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	6/473	32/9376	3.71670190274841	SUCLG2/BCKDHB/ECHDC1/ACACA/PCCA/SUCLA2	3.54812231633704
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	15/473	142/9376	2.09391656492868	MAPK8/NFE2L2/MAP2K4/PIK3CA/ITGAV/BMPR1A/AKT3/PIK3R1/GPC1/MAPK14/MAP2K5/PTK2/ACVR2A/CTNNB1/MEF2A	3.02748121965936
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	11/473	90/9376	2.42273901808786	IGF1R/PPARG/ATG5/ATF2/PIK3CA/AKT3/PIK3R1/ADCY2/CREB1/PRKACB/KRAS	3.12593669736876
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	13/473	116/9376	2.22147699934388	VAV3/ARHGAP5/PIK3CA/PIK3R1/ROCK2/GNAI1/RAP1B/MAPK14/ROCK1/CTNNA1/PTK2/ITGB1/CTNNB1	3.05110263300321
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	11/473	91/9376	2.39611551239458	VAV3/PPP3CA/GSK3B/PIK3CA/AKT3/PPP3CB/PIK3R1/MAP2K1/BANK1/KRAS/GRB2	3.08460186347339
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	5/473	24/9376	4.12966878083157	HS6ST2/EXTL2/EXT1/HS2ST1/GLCE	3.53834170546948
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	11/473	93/9376	2.34458614653663	MAPK8/MAP2K4/MAP3K1/GNAQ/ITPR2/MAP2K1/MAPK14/ADCY2/PRKACB/KRAS/GRB2	3.0035436874563
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	14/473	133/9376	2.08656948926227	PPP3CA/MAPK8/GSK3B/ATF2/PPP2R2A/AKT3/GNAQ/PPP3CB/ITPR2/GNAI1/MAPK14/GNG12/CREB1/PRKACB	2.90887374485655
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	14/473	134/9376	2.0709980751633	MYH10/PPP1R12B/CALD1/GNAQ/ITPR2/ROCK2/GNA12/MAP2K1/PPP1R12A/ADCY2/ROCK1/GNA13/PRKG1/PRKACB	2.87810165535829
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	15/473	149/9376	1.99554464577096	PDGFD/RRAS2/GAB1/DGKD/PDGFC/PIK3CA/PIP5K1B/AKT3/PIK3R1/GNA12/MAP2K1/ADCY2/GNA13/KRAS/GRB2	2.82339497066938
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	9/473	71/9376	2.51269987791442	FGFR2/MET/PIK3CA/AKT3/PIK3R1/MAP2K1/GLS/PTEN/KRAS	2.94897967528698
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	8/473	59/9376	2.68778442684631	PIK3CA/PDE3B/AKT3/PIK3R1/GNAI1/ADCY2/PRKG1/PRKACB	2.99745695618067
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	14/473	138/9376	2.01096914544842	IGF1R/PPP3CA/SPDYE5/FBXW11/CPEB2/PPP3CB/SLK/ITPR2/ANAPC10/MAP2K1/MAPK14/ADCY2/PRKACB/BTRC	2.75763312578506
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	11/473	98/9376	2.2249644043664	DGKD/MTMR3/PIK3CA/INPP4B/PIP5K1B/PIK3R1/ITPR2/PIKFYVE/PTEN/PIK3C2A/PPIP5K2	2.80968313452266
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	15/473	154/9376	1.93075423519398	CACNA2D3/PPP3CA/PPP1R12B/GNAQ/PPP3CB/ITPR2/ROCK2/GNAI1/MAP2K1/PPP1R12A/MAP2K5/ADCY2/ROCK1/PRKACB/KRAS	2.6842987207408
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	16/473	170/9376	1.86563860216391	PATJ/RAPGEF2/PRKCI/NEDD4/MAPK8/MYH10/PARD3/MAP3K1/NEDD4L/PPP2R2A/ROCK2/ROCK1/AMOT/ITGB1/DLG1/PRKACB	2.62526780338298
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	8/473	62/9376	2.55773034167633	IGF1R/ATG5/PIK3CA/AKT3/PIK3R1/ADCY2/PRKACB/KRAS	2.83640360748805
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	12/473	115/9376	2.06842540674694	PIK3CA/AKT3/GNAQ/PIK3R1/ITPR2/GNAI1/MAP2K1/ADCY2/GNG12/CREB1/PRKACB/KRAS	2.65712635358542
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	21/473	248/9376	1.67851053672509	NAIP/EXOC4/MAPK8/MAP2K4/TCF7L2/PIK3CA/WASL/AKT3/ROCK2/VPS41/MAP2K1/MAPK14/NCKAP1/GCC2/DCTN4/PIK3C2A/TAB2/EXOC2/CTNNB1/KPNA4/MYO6	2.49598886111335
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	12/473	116/9376	2.0505941532405	HOMER1/GRIK2/PPP3CA/GNAQ/PPP3CB/ITPR2/GNAI1/SLC38A1/ADCY2/GNG12/GLS/PRKACB	2.62425783612111
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	10/473	90/9376	2.2024900164435	EML4/PPP3CA/PIK3CA/AKT3/PPP3CB/PIK3R1/MAP2K1/MAPK14/PTEN/KRAS	2.64202191887043
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	9/473	77/9376	2.31690508223278	CDK6/PIK3CA/MDM2/AKT3/PIK3R1/MAP2K1/ABL1/KRAS/GRB2	2.67442075719206
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	8/473	65/9376	2.43968124898357	ESR2/PIK3CA/AKT3/GNAQ/PIK3R1/ITPR2/MAP2K1/KRAS	2.6845585796889
Human Diseases	Substance dependence	hsa05032	Morphine addiction	10/473	91/9376	2.17828682944962	PDE4B/PDE10A/PDE7A/PDE3B/GNAI1/GABRB1/ADCY2/GNG12/PRKACB/GABRA4	2.60332738771205
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	9/473	78/9376	2.2872011709221	CNOT2/PAN3/PABPC1/ZCCHC7/CNOT4/TENT4B/XRN1/BTG3/CNOT6L	2.63115830519559
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	11/473	105/9376	2.0766334440753	RRAS2/PPP3CA/MAPK8/PIK3CA/MDM2/AKT3/PPP3CB/PIK3R1/ITPR2/MAPK14/KRAS	2.55709726255857
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	11/473	105/9376	2.0766334440753	ITGB8/DMD/SNTB1/CACNA2D3/ITGAV/ITGA6/SGCE/ADCY2/ITGB1/PRKACB/ITGB6	2.55709726255857
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	15/473	163/9376	1.82414817312806	MAPK8/MAP2K4/MAP3K1/ATF2/PIK3CA/AKT3/PIK3R1/MAP2K1/MAPK14/CREB1/CREBBP/TAB2/KRAS/EP300/GRB2	2.44650771015445
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	5/473	32/9376	3.09725158562368	ATG5/ATG10/ATG4C/ATG2B/ULK2	2.73909520451855
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	13/473	138/9376	1.8673284922021	PRKCI/PHKB/MAPK8/GSK3B/ACACA/PIK3CA/PDE3B/AKT3/PIK3R1/MAP2K1/PRKACB/KRAS/GRB2	2.36582272743136
Organismal Systems	Endocrine system	hsa04924	Renin secretion	8/473	69/9376	2.29825045194105	PPP3CA/PDE3B/GNAQ/PPP3CB/ITPR2/GNAI1/CREB1/PRKACB	2.4947451830409
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	17/473	200/9376	1.68490486257928	NAIP/MYO1D/MAPK8/SEC24B/MYH10/WASL/ROCK2/GNA12/NCK1/MAPK14/ROCK1/NCKAP1/ABL1/GNA13/ITGB1/TAB2/MYO6	2.25666226477326
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	14/473	155/9376	1.79041123917343	PBX1/CDK6/GSK3B/TCF7L2/ATF2/GNAQ/ITPR2/GNAI1/RAP1B/MAP2K1/ADCY2/CREB1/PRKACB/CTNNB1	2.28706215231142
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	13/473	142/9376	1.81472768960486	PPARG/PPP3CA/MAPK8/PIK3CA/AKT3/PPP3CB/PIK3R1/ITPR2/MAP2K1/MAPK14/CREB1/TAB2/GRB2	2.25480887527833
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	20/473	250/9376	1.58579281183932	DNAJC6/IGF1R/EEA1/PRKCI/NEDD4/PARD3/FGFR2/MDM2/NEDD4L/PIP5K1B/WASL/SMURF1/EPS15/SMAD2/WWP1/PSD3/PDCD6IP/ARAP2/ITCH/SNX4	2.16382349565687
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	14/473	158/9376	1.75641608906254	IGF1R/GSK3B/PIK3CA/SKP2/AKT3/PIK3R1/MAP2K1/SLC38A9/RICTOR/PTEN/ATP6V1H/ULK2/KRAS/GRB2	2.21013586032901
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	13/473	144/9376	1.78952313836035	PUM2/MAPK8/RBPJ/PIK3CA/PSMD14/PUM1/AKT3/GNAQ/PIK3R1/ITPR2/ATG2B/ULK2/ATXN2	2.20062596225049
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	8/473	75/9376	2.11439041578576	ATM/PIK3CA/MDM2/ATP7B/AKT3/PIK3R1/TOP2B/REV3L	2.23332125752541
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	10/473	103/9376	1.92450583961083	MAPK8/MAP2K4/PIK3CA/PPP2R2A/AKT3/GNAQ/PIK3R1/GNAI1/SMAD2/MAPK14	2.1745338025821
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	9/473	89/9376	2.00451338575195	FRAS1/ITGB8/FREM2/LAMB1/ITGAV/ITGA6/LAMC1/ITGB1/ITGB6	2.19462858101478
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	11/473	119/9376	1.83232362712527	MAPK8/MAP2K4/ATF2/PIK3CA/AKT3/PIK3R1/MAP2K1/MAPK14/CREB1/ITCH/TAB2	2.10609808777457
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	8/473	77/9376	2.05947118420691	CDK6/MAPK8/PIK3CA/AKT3/PIK3R1/SMAD2/MAP2K1/KRAS	2.15161423926298
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	8/473	78/9376	2.03306770748631	MTMR3/PIK3CA/INPP4B/PIP5K1B/PIKFYVE/PTEN/PIK3C2A/PPIP5K2	2.11168598956042
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	7/473	65/9376	2.13472109286063	PBX1/ATF2/GNAQ/ITPR2/ADCY2/CREB1/PRKACB	2.11590256353177
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	10/473	109/9376	1.81856973834785	MAPK8/GSK3B/PIK3CA/AKT3/PIK3R1/SLC27A6/CREB1/PTEN/OGT/SLC27A2	1.9812869296155
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	10/473	110/9376	1.80203728618105	BMPR1A/FBN1/SMURF1/SMAD2/LEMD3/ROCK1/CREBBP/ACVR2A/BMP7/EP300	1.95026117613723
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	13/473	157/9376	1.64134606320949	PBX1/PPARG/ANO6/ABCA1/ATP11B/ITGAV/DOCK1/VPS41/MAP2K1/MAPK14/PTK2/CREB1/ADAM10	1.86787742736404
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	7/473	68/9376	2.04054222111678	TCF7L2/PIK3CA/AKT3/PIK3R1/MAP2K1/KRAS/GRB2	1.9848788211634
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	3/473	18/9376	3.30373502466526	ACACA/ACSL4/CBR4	2.25488957698397
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	9/473	99/9376	1.80203728618105	ITGB8/DMD/SNTB1/CACNA2D3/ITGAV/ITGA6/SGCE/ITGB1/ITGB6	1.84908297391607
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	7/473	73/9376	1.90077905528686	TRIM5/NUP153/MDFIC/CPSF6/PDCD6IP/CREBBP/EP300	1.78080440379289
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	8/473	89/9376	1.78178967622396	GNAI1/SLC38A1/GABRB1/ADCY2/GNG12/GLS/PRKACB/GABRA4	1.70802897414755
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	17/473	233/9376	1.4462702683084	FBN2/DIAPH2/ITGB8/FMNL2/DMD/SNTB1/MYH10/ITGAV/ITGA6/SGCE/FBN1/DIAPH3/SYNE2/DSG2/TMOD3/ITGB1/ITGB6	1.58993575672097
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	4/473	33/9376	2.40271638157473	STX17/STX7/VTI1A/STX6	1.86050861913551
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	15/473	201/9376	1.47928433940235	PBX1/SUPT3H/IGF1R/PPARG/JMJD1C/FUT8/KDM6A/ATM/MET/MDM2/ETV6/BMP2K/CDK14/PTK2/SS18	1.58320171919067
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	7/473	75/9376	1.85009161381254	CDK6/COP1/ATM/MDM2/PTEN/ATR/MDM4	1.70364680553446
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	7/473	75/9376	1.85009161381254	LRP2/ATF2/GNAQ/ITPR2/ADCY2/CREB1/PRKACB	1.70364680553446
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	3/473	21/9376	2.83177287828451	CHST11/DSE/UST	1.93690088584316
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	4/473	34/9376	2.33204825270489	FBXW11/NR1D2/CREB1/BTRC	1.79344270196524
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	6/473	62/9376	1.91829775625725	TLE4/MAML3/RBPJ/ITCH/CREBBP/EP300	1.67208855018723
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	5/473	48/9376	2.06483439041579	BCKDHB/ALDH7A1/PCCA/AUH/BCAT1	1.70473328455016
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	4/473	36/9376	2.2024900164435	PRIM2/POLA1/RFC3/RFC1	1.66612397397127
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	11/473	144/9376	1.51421188630491	MAPK8/TRA2A/MAP2K4/GSK3B/TCF7L2/ACACA/ALDH7A1/AKT3/MAPK14/TAB2/CTNNB1	1.43325505247436
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	9/473	112/9376	1.59287224403503	MAPK8/LAMB1/ITGA6/LAMC1/AKT3/GNAI1/MAPK14/ITGB1/TAB2	1.45485221257144
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	8/473	98/9376	1.61815593044829	VAV3/PIK3CA/PIP5K1B/AKT3/PIK3R1/SCIN/DOCK1/MAP2K1	1.41785531570942
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	4/473	38/9376	2.08656948926227	PIK3CA/NEDD4L/PIK3R1/KRAS	1.54692903615494
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	9/473	115/9376	1.55131905506021	GNAQ/ITPR2/APP/GNAI1/MAP2K1/GABRB1/GNG12/PRKACB/KRAS	1.371105910795
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	8/473	99/9376	1.60181092104982	MAPK8/PIK3CA/GNAQ/PIK3R1/ITPR2/MAPK14/ADCY2/PRKACB	1.3874645815142
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	4/473	39/9376	2.03306770748631	AHCYL2/GLDC/MTR/ALDH7A1	1.49006574956421
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	2/473	13/9376	3.04960156122947	MRE11/XRCC4	1.70443965397523
NA	NA	hsa04081	Hormone signaling	15/473	219/9376	1.3576993252049	IGF1R/ESR2/PIK3CA/ITGAV/BMPR1A/GNAQ/PIK3R1/GNAI1/GNA12/ADCY2/GNG12/GNA13/SLC40A1/PRKG1/PRKACB	1.23455827005591
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	6/473	71/9376	1.67513325194295	MAPK8/MAP2K4/MET/MAPK14/ATP6V1H/ADAM10	1.31615944917977
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	4/473	41/9376	1.93389367297478	MDM2/MAP2K1/CDH1/KRAS	1.38127522493144
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	11/473	154/9376	1.41588643914225	ATP2B1/CACNA2D3/ATF2/PPP2R2A/AKT3/GNAQ/GNAI1/MAPK14/ADCY2/CREB1/PRKACB	1.19941805726012
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	8/473	105/9376	1.5102788684184	RRAS2/MAPK8/USP15/SMURF1/MTX2/OPTN/BCL2L13/KRAS	1.21195631136545
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	11/473	156/9376	1.39773404889684	PIAS1/CDK6/GSK3B/PIK3CA/PPP2R2A/AKT3/PIK3R1/MAP2K1/KRAS/CTNNB1/GRB2	1.15461616067475
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	15/473	227/9376	1.30985089083645	MAPK8/NFE2L2/MAP2K4/MET/PIK3CA/AKT3/PIK3R1/MAP2K1/MAPK14/PTK2/ABL1/PTEN/KRAS/SLC26A2/GRB2	1.08924828742031
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	8/473	109/9376	1.45485579067828	MAPK8/MAP2K4/PIK3CA/AKT3/PIK3R1/MAP2K1/MAPK14/TAB2	1.10094447755878
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	20/473	323/9376	1.2273938172131	TP63/CDK6/FOXP1/ATM/MET/PIK3CA/MDM2/PIK3R1/EFNA5/PDCD4/MAP2K1/ROCK1/GLS/ABL1/PTEN/CREBBP/MDM4/KRAS/EP300/GRB2	0.95858730911804
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/473	17/9376	2.33204825270489	MYH10/PCDH11X	1.26700321274281
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	5/473	63/9376	1.5732071546025	ALDH7A1/NSD1/SETD2/AASS/KMT2C	1.05216802018582
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	5/473	63/9376	1.5732071546025	MNAT1/CCNH/RAD23B/RFC3/RFC1	1.05216802018582
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	16/473	254/9376	1.2486557573538	PDGFD/ATP2B1/ASPH/PHKB/PPP3CA/FGFR2/ERBB4/PDGFC/MET/GNAQ/PPP3CB/ITPR2/ADCY2/EDNRB/PRKACB/MCOLN3	0.926015733288143
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	7/473	97/9376	1.43048320655609	GNAQ/GNAI1/ADCY2/GNG12/CREB1/PRKG1/PRKACB	0.982289531408061
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	10/473	149/9376	1.33036309718064	MAPK8/GNAQ/ITPR2/GNAI1/GABRB1/MAPK14/ADCY2/GNG12/PRKACB/GABRA4	0.936919816742375
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	7/473	98/9376	1.41588643914225	ATP2B1/ATF2/GNAQ/ITPR2/ADCY2/CREB1/PRKACB	0.95391270943834
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	2/473	18/9376	2.2024900164435	MTR/LMBRD1	1.1769939578445
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	4/473	49/9376	1.61815593044829	ATF2/GNAI1/CREB1/PRKACB	0.9999380937774
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	13/473	205/9376	1.25703088743361	CDK6/NEDD4/MAPK8/MAP2K4/RBPJ/PIK3CA/PSMD14/MDM2/SKP2/AKT3/PIK3R1/MAPK14/TAB2	0.857633864798569
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	7/473	101/9376	1.37383040629644	MAPK8/PIK3CA/AKT3/PIK3R1/SMAD2/MAPK14/KRAS	0.870615454953066
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	2/473	19/9376	2.08656948926227	GLDC/BCKDHB	1.09273288626463
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	7/473	103/9376	1.34715408772758	PIK3CA/LAMB1/LAMC1/GNAQ/PIK3R1/PTK2/PRKACB	0.816542488023601
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	5/473	69/9376	1.43640653246316	PPP3CA/ATF2/PPP3CB/CREB1/PRKACB	0.838607907343502
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	8/473	122/9376	1.29983017363879	IGF1R/PPARG/ACACA/PIK3CA/PPP2R2A/AKT3/PIK3R1/CREB1	0.768313609122358
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	5/473	70/9376	1.41588643914225	DMD/SNTB1/SGCE/ABL1/EIF4G3	0.804989614315866
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/473	21/9376	1.887848585523	DPYD/BCAT1	0.938803457666988
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	4/473	54/9376	1.468326677629	AHCYL2/MTR/APIP/BCAT1	0.795498289236786
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	4/473	54/9376	1.468326677629	POLI/REV3L/ATR/REV1	0.795498289236786
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	14/473	235/9376	1.18090954073141	FRS2/PPARG/ARID1B/COA1/ATF2/ACSL4/SMARCA2/MAPK14/ADCY2/CREB1/PRKG1/PRKACB/KRAS/GRB2	0.647361056179279
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	13/473	217/9376	1.18751765863544	ESR2/ATF2/PIK3CA/AKT3/PIK3R1/GNAI1/MAP2K1/ADCY2/CREB1/PRKACB/KRAS/KPNA4/GRB2	0.644163378538273
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	11/473	181/9376	1.20467685982269	PLA2R1/EEA1/PPP3CA/MAPK8/AKT3/PPP3CB/MAPK14/CREB1/ATP6V1H/CREBBP/EP300	0.640885119381471
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	7/473	110/9376	1.26142610032673	IGF1R/PIK3CA/AKT3/PIK3R1/MAP2K1/CREBBP/EP300	0.635692607663998
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	2/473	23/9376	1.72368783895579	RFC3/RFC1	0.800917434214288
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/473	23/9376	1.72368783895579	ENPEP/MME	0.800917434214288
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	6/473	93/9376	1.27886517083816	MAML3/PPP3CA/MAPK8/RBPJ/PPP3CB/MAPK14	0.622930502206813
Organismal Systems	Digestive system	hsa04970	Salivary secretion	6/473	93/9376	1.27886517083816	ATP2B1/GNAQ/ITPR2/ADCY2/PRKG1/PRKACB	0.622930502206813
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	5/473	76/9376	1.30410593078892	PPARG/ACSL4/SLC27A6/OLR1/SLC27A2	0.613533433318484
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	5/473	76/9376	1.30410593078892	GNAQ/ITPR2/GNAI1/ADCY2/PRKACB	0.613533433318484
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	10/473	168/9376	1.17990536595188	PIAS1/IL6ST/PIK3CA/AKT3/PIK3R1/CSF2RA/CREBBP/EP300/PTPN2/GRB2	0.542330618828644
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	3/473	41/9376	1.45042025473109	ATM/MRE11/BARD1	0.666193975472152
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	3/473	42/9376	1.41588643914225	ATG5/ACSL4/SLC40A1	0.622606324976515
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	8/473	133/9376	1.19232542243558	VAV3/PPP3CA/PIK3CA/PPP3CB/PIK3R1/MAP2K1/KRAS/GRB2	0.514877674479108
Organismal Systems	Digestive system	hsa04978	Mineral absorption	4/473	61/9376	1.29983017363879	ATP2B1/TRPM7/ATP7B/SLC40A1	0.541497986437873
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	7/473	117/9376	1.18595616270035	ARID1B/EPC2/ARID2/EPC1/SMARCA2/BAZ2B/SS18	0.466519161551874
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	9/473	155/9376	1.15097865375435	PLA2R1/EEA1/STX7/COLEC12/ITGAV/OLR1/PIKFYVE/ATP6V1H/ITGB1	0.436858115997431
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	14/473	250/9376	1.11005496828753	STX17/AP3B1/VPS13C/MANBA/VPS41/SLC38A9/DMXL1/VPS13A/OSBPL3/PIKFYVE/ATP6V1H/AP1G1/SPG11/MCOLN3	0.406525176446925
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	3/473	44/9376	1.35152796463579	MNAT1/TAF4B/CCNH	0.538699874840136
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	3/473	44/9376	1.35152796463579	PARG/RFC3/RFC1	0.538699874840136
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	3/473	44/9376	1.35152796463579	CREB1/DCTN4/PRKACB	0.538699874840136
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	8/473	137/9376	1.15751300134257	MAPK8/ATM/PIK3CA/AKT3/PIK3R1/ITPR2/MAP2K1/KRAS	0.428067472858592
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	4/473	63/9376	1.258565723682	GLI3/GSK3B/TCF7L2/CTNNB1	0.474618265647899
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	5/473	83/9376	1.1941210932525	FAR1/CROT/ACSL4/ABCD3/SLC27A2	0.409432042588944
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	9/473	160/9376	1.11501057082452	NRXN3/ITGB8/ITGAV/ITGA6/CADM1/CDH1/NRCAM/ITGB1/CNTNAP2	0.338200728793084
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	3/473	47/9376	1.26526022221223	ACACA/ALDH7A1/ACYP2	0.420195631885177
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	3/473	47/9376	1.26526022221223	MAPK8/PIK3CA/PIK3R1	0.420195631885177
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	5/473	86/9376	1.15246570627858	ATF2/GNAQ/ADCY2/CREB1/PRKACB	0.327387098095091
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	3/473	48/9376	1.23890063424947	PIK3CA/AKT3/PIK3R1	0.382464979128064
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	2/473	30/9376	1.3214940098661	SUCLG2/SUCLA2	0.406507578354144
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	2/473	30/9376	1.3214940098661	PGAP1/PIGN	0.406507578354144
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/473	31/9376	1.27886517083816	ALDH7A1/DPYD	0.358454050237968
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	2/473	31/9376	1.27886517083816	GLDC/PCCA	0.358454050237968
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/473	31/9376	1.27886517083816	IMMP2L/IMMP1L	0.358454050237968
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	7/473	128/9376	1.08403805496829	PDE4B/ADK/FHIT/PDE10A/PDE7A/PDE3B/ADCY2	0.220650587648474
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	10/473	187/9376	1.06002193304768	NAIP/PKN2/MAPK8/ATG5/TRPM7/ERBIN/ITPR2/MAPK14/ANTXR2/TAB2	0.191092955520411
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	6/473	109/9376	1.09114184300871	PPP3CA/MAPK8/IL6ST/PPP3CB/SMAD2/MAPK14	0.220602025502055
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/473	32/9376	1.23890063424947	MAPK8/BIRC6	0.312013869063101
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	3/473	52/9376	1.14360058546105	IGF1R/ADCY2/PRKACB	0.239334205308547
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	20/473	388/9376	1.02177371896864	PPP3CA/MAPK8/GSK3B/PIK3CA/PSMD14/AKT3/GNAQ/PPP3CB/CSNK1A1/PIK3R1/ITPR2/APP/MAP2K1/ATG2B/ULK2/SLC39A10/KRAS/CTNNB1/ADAM10/MME	0.100963632190173
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	4/473	72/9376	1.10124500822175	MAPK8/ATG5/MAP3K1/MAPK14	0.198771007595996
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	2/473	33/9376	1.20135819078737	BCKDHB/BCAT1	0.267073696731807
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	3/473	53/9376	1.12202321592405	ATP2B1/GNAQ/PRKACB	0.205329136718057
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/473	14/9376	1.41588643914225	FUT8	0.358923984927741
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	5/473	94/9376	1.05438351851019	USP25/MAPK8/GSK3B/MAPK14/TAB2	0.122140155571384
Human Diseases	Infectious disease: viral	hsa05162	Measles	7/473	136/9376	1.02027111055839	CDK6/MAPK8/GSK3B/PIK3CA/AKT3/PIK3R1/TAB2	0.0548856779179145
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/473	15/9376	1.3214940098661	TPK1	0.287213873600578
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	8/473	157/9376	1.01005911582123	PPARG/MAPK8/GSK3B/PIK3CA/AKT3/PIK3R1/MAPK14/ITCH	0.029296500687445
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	3/473	56/9376	1.06191482935669	NAIP/BCL2L13/CLK4	0.107109689296079
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	3/473	57/9376	1.04328474463113	ACACA/ACSL4/CBR4	0.0755502061102264
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	4/473	78/9376	1.01653385374316	MAPK8/GNAI1/MAPK14/ITGB1	0.0337967270197792
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/473	17/9376	1.16602412635244	MTR	0.157917028196401
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/473	17/9376	1.16602412635244	CA8	0.157917028196401
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	5/473	102/9376	0.97168677196037	ATP2B1/GNAQ/ITPR2/RAP1B/ADCY2	-0.0662680130087572
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	5/473	103/9376	0.962252919805415	MSI2/PPP2R2A/PABPC1/CPSF6/RNGTT	-0.0887850550153967
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	5/473	103/9376	0.962252919805415	COL21A1/COL14A1/COL19A1/COL28A1/MME	-0.0887850550153967
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/473	18/9376	1.10124500822175	MANBA	0.0990983387050161
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	2/473	41/9376	0.966946836487392	GLDC/ALDH7A1	-0.0488872739871379
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	2/473	41/9376	0.966946836487392	GABRB1/GABRA4	-0.0488872739871379
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	13/473	275/9376	0.937059388814146	PPP3CA/MAPK8/GSK3B/ATF2/PIK3CA/PSMD14/LAMC1/PPP3CB/PIK3R1/ITPR2/MAPK14/CREB1/PRKACB	-0.244174758825928
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	5/473	108/9376	0.917704173518127	RANBP17/NUP153/AHCTF1/KPNA4/NUP58	-0.198264380885123
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/473	20/9376	0.991120507399577	NPL	-0.00916233280761703
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	2/473	43/9376	0.921972565022862	ALDH7A1/ACSL4	-0.118200400260557
Cellular Processes	Cell motility	hsa04814	Motor proteins	9/473	194/9376	0.919596347071773	MYO1D/MYH10/DNAH14/KIF16B/DNAH11/KIF13B/DCTN4/MYO6/HOOK3	-0.26082908800355
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	2/473	44/9376	0.901018643090525	FUT8/MAN1A1	-0.151684218448699
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/473	45/9376	0.880996006577402	ABCA1/ABCD3	-0.18443855852028
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/473	22/9376	0.901018643090525	ALDH7A1	-0.107130734538911
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	2/473	46/9376	0.861843919477893	PSMD14/PSME4	-0.216499112151292
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	3/473	70/9376	0.849531863485352	MAPK8/ACSL4/AKT3	-0.291246060894818
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	14/473	308/9376	0.901018643090525	PPARG/MAPK8/DNAH14/TAF4B/PSMD14/GNAQ/RCOR1/DNAH11/ATG2B/CREB1/ULK2/CREBBP/DCTN4/EP300	-0.40711867793145
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/473	23/9376	0.861843919477893	GLS	-0.152899644814439
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/473	23/9376	0.861843919477893	PDSS2	-0.152899644814439
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/473	23/9376	0.861843919477893	GLS	-0.152899644814439
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	22/473	480/9376	0.908527131782946	PPP3CA/MAPK8/DNAH14/GSK3B/PSMD14/C9orf72/GNAQ/PPP3CB/CSNK1A1/ITPR2/APP/DNAH11/MAP2K1/MAPK14/OPTN/ATG2B/ULK2/DCTN4/ATXN2/SPG11/KRAS/CTNNB1	-0.474202184665773
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	2/473	49/9376	0.809077965224145	GALNT11/OGT	-0.308838281912822
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	2/473	51/9376	0.777349417568296	ATP6V1H/PRKACB	-0.367478999446171
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/473	26/9376	0.762400390307367	LMBRD1	-0.279624109037003
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	2/473	52/9376	0.762400390307367	LRP2/ABCA1	-0.395999177752874
Human Diseases	Substance dependence	hsa05034	Alcoholism	8/473	191/9376	0.830258016669803	ATF2/GNAI1/MAP2K1/GNG12/CREB1/PRKACB/KRAS/GRB2	-0.546278863880181
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	3/473	78/9376	0.762400390307367	MAPK14/ITGB1/TAB2	-0.485675588615382
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/473	28/9376	0.707943219571126	GCNT2	-0.356726176555264
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	16/473	368/9376	0.861843919477893	PPP3CA/DNAH14/ERBB4/PSMD14/NUP153/C9orf72/PPP3CB/DNAH11/MAPK14/OPTN/ATG2B/ULK2/DCTN4/ATXN2/SPG11/NUP58	-0.623200432831656
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	2/473	55/9376	0.72081491447242	SGMS1/CERS6	-0.478619431484446
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	7/473	173/9376	0.802062838358039	CDK6/PIK3CA/AKT3/PIK3R1/MAP2K1/CREBBP/EP300	-0.605666705949395
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	4/473	104/9376	0.762400390307367	ETNK1/DGKD/GPD1L/SGMS1	-0.561595608309156
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	7/473	174/9376	0.797453281815752	MAPK8/NFE2L2/SEC24B/MAN1A1/UBE4B/RAD23B/UBE2D2	-0.621593897841848
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	2/473	56/9376	0.707943219571126	FUT8/MAN1A1	-0.505244241703943
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/473	30/9376	0.660747004933051	MTR	-0.428962622138722
NA	NA	hsa04082	Neuroactive ligand signaling	8/473	199/9376	0.796880809969509	GRIK2/GNAQ/GNAI1/GABRB1/ADCY2/GNG12/PRKACB/GABRA4	-0.667536704367622
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/473	31/9376	0.639432585419082	DERA	-0.463474336905879
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/473	31/9376	0.639432585419082	ALDH7A1	-0.463474336905879
NA	NA	hsa04981	Folate transport and metabolism	1/473	31/9376	0.639432585419082	MTR	-0.463474336905879
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	8/473	205/9376	0.773557469189914	MAPK8/GSK3B/PIK3CA/AKT3/PIK3R1/SMAD2/MAPK14/PTEN	-0.755569825838871
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	4/473	116/9376	0.683531384413501	SUCLG2/GLDC/PCCA/SUCLA2	-0.790500538935656
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/473	36/9376	0.550622504110876	AGL	-0.622640195781802
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/473	36/9376	0.550622504110876	GALNT11	-0.622640195781802
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	2/473	65/9376	0.609920312245894	DGKD/ALDH7A1	-0.72737751725389
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/473	37/9376	0.535740814810582	GLS	-0.652167572988042
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/473	37/9376	0.535740814810582	GNAQ	-0.652167572988042
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	3/473	100/9376	0.594672304439746	ITGA6/CSF2RA/MME	-0.939234272402008
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/473	42/9376	0.471962146380751	ALDH7A1	-0.790503552288023
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/473	43/9376	0.460986282511431	ABCA1	-0.816528662921543
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	2/473	75/9376	0.528597603946441	MTR/BCAT1	-0.944725454420291
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	3/473	105/9376	0.566354575656901	ERC1/ATM/TAB2	-1.02994527395642
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	2/473	79/9376	0.501833168303583	SYT1/ATP6V1H	-1.02486098523528
NA	NA	hsa03272	Virion - Hepatitis viruses	1/473	48/9376	0.412966878083157	PDCD6IP	-0.939803326294034
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/473	50/9376	0.396448202959831	ALDH7A1	-0.986279180947111
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	1/473	50/9376	0.396448202959831	MET	-0.986279180947111
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/473	86/9376	0.460986282511431	PRKACB/GABRA4	-1.15741527133715
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	2/473	87/9376	0.455687589609001	ASPH/CACNA2D3	-1.17563201177965
Organismal Systems	Digestive system	hsa04976	Bile secretion	2/473	90/9376	0.440498003288701	ADCY2/PRKACB	-1.22929630911615
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/473	59/9376	0.335973053355789	DPYD	-1.17929289940732
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	5/473	180/9376	0.550622504110876	PIK3CA/AKT3/PIK3R1/POU2F1/TAB2	-1.40312419326737
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	7/473	238/9376	0.583012063176222	MAPK8/IL6ST/PIK3CA/PIK3R1/NRP1/MAPK14/TAB2	-1.50187716730038
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	2/473	100/9376	0.396448202959831	IL6ST/CCR3	-1.39856353059318
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	1/473	66/9376	0.300339547696842	SMAD2	-1.31471759642408
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	1/473	67/9376	0.295856867880471	ALDH7A1	-1.33319862113155
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	5/473	195/9376	0.508266926871578	PIK3CA/AKT3/PIK3R1/MAP2K1/MAPK14	-1.59937297383292
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	7/473	268/9376	0.517749518790824	MAPK8/NFE2L2/PSMD14/ITPR2/GNAI1/SLC39A10/PRKACB	-1.84619077938588
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1/473	82/9376	0.241736709121848	DPYD	-1.58954799426438
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	1/473	82/9376	0.241736709121848	CREB1	-1.58954799426438
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	1/473	83/9376	0.238824218650501	G3BP1	-1.60543993290715
NA	NA	hsa04382	Cornified envelope formation	5/473	217/9376	0.45673756101363	KAZN/DST/ITGA6/PPP2R2A/DSG2	-1.86622300361992
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	1/473	85/9376	0.233204825270489	ADK	-1.63683772543484
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	1/473	88/9376	0.225254660772631	F5	-1.68301205545106
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	1/473	95/9376	0.208656948926227	ATP6V1H	-1.7868052970485
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	2/473	138/9376	0.287281306492631	PPA2/ATP6V1H	-1.94409165445935
Genetic Information Processing	Transcription	hsa03040	Spliceosome	5/473	243/9376	0.407868521563612	USP39/TRA2A/HNRNPC/AQR/TCERG1	-2.15557222596731
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	3/473	183/9376	0.324957543409697	MDN1/EFL1/XRN1	-2.12557300179602
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	2/473	154/9376	0.257433898025864	TPK1/BCAT1	-2.1415634355714
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	6/473	298/9376	0.399108929154192	IL6ST/BMPR1A/CSF2RA/CCR3/ACVR2A/BMP7	-2.42972328221408
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	2/473	168/9376	0.235981073190375	MAPK8/TRPM7	-2.30316008186378
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	5/473	370/9376	0.267870407405291	GRIK2/NR3C1/GABRB1/EDNRB/GABRA4	-3.31185164267108
Genetic Information Processing	Translation	hsa03010	Ribosome	1/473	222/9376	0.0892901358017637	MRPL1	-3.16518497620577
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/473	449/9376	0.0882958135767997	PRKG1/PRKACB	-4.56323015759065