category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	55/502	238/9376	4.31618065552914	ISG15/FOS/VWF/RPL15/RPL19/RPS25/RPS3/RPL14/IL6ST/RPL28/RPS18/RPL3/RPS9/OAS1/RPS7/MX1/RPS6/RPL41/RPS8/RPS13/RPL8/RPS15/RPL18/RPL13A/RPL36AL/RPL10A/RPS24/RPL29/RPL36/FAU/RPS4X/RPS27L/OAS2/RPS15A/CCL2/RPL23/RPL11/RPS14/RPS23/RPL4/RPL21/RPL23A/RPL24/RPS27A/RPSA/RPS19/RPL27/UBA52/RPL7A/STAT1/EIF2AK2/RPLP0/RPL5/RPL7/RPL6	12.3247712610265
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	55/502	268/9376	3.83302610453708	MT-ND3/MT-ND4/MT-CYB/MT-CO2/TUBA1B/MT-ATP6/MT-CO3/MT-ND5/MT-ND2/MT-CO1/TUBB/UBB/TUBB4B/SOD1/HSPA5/MT-ND1/GNAS/TUBA1A/PSMB6/MT-ND6/ATP5F1E/ATP5F1B/CALM1/MT-ND4L/NDUFA6/PSMB3/GNAI2/COX4I1/ATP5MC2/NDUFA12/PARK7/PSMC3/TUBB6/PSMC2/UBC/SEM1/COX7C/PSMB2/NDUFA1/TXN/NDUFA4/COX5B/ATP5F1A/SDHA/COX7A2L/COX7A2/RPS27A/NDUFB5/UQCR10/UBA52/PSMB7/PSMA4/PSMB1/PSMD2/UBE2L6	11.191395579515
Genetic Information Processing	Translation	hsa03010	Ribosome	47/502	222/9376	3.95420121316536	RPL15/RPL19/RPS25/RPS3/RPL14/RPL28/RPS18/RPL3/RPS9/RPS7/RACK1/RPS6/RPL41/RPS8/RPS13/RPL8/RPS15/RPL18/RPL13A/RPL36AL/RPL10A/RPS24/RPL29/RPL36/FAU/RPS4X/RPS27L/MRPL16/RPS15A/RPL23/RPL11/RPS14/RPS23/RPL4/RPL21/RPL23A/RPL24/RPS27A/RPSA/RPS19/RPL27/UBA52/RPL7A/RPLP0/RPL5/RPL7/RPL6	10.5947055180481
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	51/502	275/9376	3.4637884824339	MT-ND3/MT-ND4/MT-CYB/MT-CO2/TUBA1B/MT-ATP6/MT-CO3/MT-ND5/CAV1/MT-ND2/MT-CO1/TUBB/HSPA8/TUBB4B/SOD1/HSPA5/MT-ND1/TUBA1A/PSMB6/MT-ND6/ATP5F1E/ATP5F1B/MT-ND4L/NDUFA6/PSMB3/COX4I1/ATP5MC2/NDUFA12/PSMC3/TUBB6/PSMC2/SEM1/CAV2/COX7C/PSMB2/NDUFA1/NDUFA4/COX5B/ATP5F1A/SDHA/COX7A2L/CREB3L2/NCAM1/LAMC1/COX7A2/NDUFB5/UQCR10/PSMB7/PSMA4/PSMB1/PSMD2	9.86286287257687
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	52/502	308/9376	3.15330884255187	MT-ND3/MT-ND4/MT-CYB/MT-CO2/TUBA1B/MT-ATP6/MT-CO3/MT-ND5/MT-ND2/MT-CO1/TUBB/TUBB4B/SOD1/MT-ND1/TUBA1A/PSMB6/MT-ND6/ATP5F1E/ATP5F1B/RB1CC1/MT-ND4L/NDUFA6/PSMB3/COX4I1/ATP5MC2/NDUFA12/POLR2L/PSMC3/TUBB6/PSMC2/SEM1/COX7C/PSMB2/NDUFA1/NDUFA4/COX5B/ATP5F1A/SDHA/AP2M1/COX7A2L/PPARG/CREB3L2/TGM2/COX7A2/NDUFB5/UQCR10/HDAC2/PSMB7/PSMA4/PSMB1/PSMD2/ACTR10	9.13910592448029
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	53/502	368/9376	2.68993590853975	MT-ND3/ACTB/MT-ND4/MT-CYB/MT-CO2/TUBA1B/MT-ATP6/ACTG1/MT-CO3/MT-ND5/MT-ND2/MT-CO1/TUBB/TUBB4B/SOD1/HSPA5/MT-ND1/SRSF3/TUBA1A/PSMB6/MT-ND6/ATP5F1E/ATP5F1B/RB1CC1/MT-ND4L/NDUFA6/PSMB3/COX4I1/ATP5MC2/NDUFA12/PSMC3/TUBB6/PSMC2/SEM1/SRSF7/COX7C/PSMB2/NDUFA1/NDUFA4/COX5B/ATP5F1A/SDHA/COX7A2L/TPR/COX7A2/NDUFB5/UQCR10/NRG3/PSMB7/PSMA4/PSMB1/PSMD2/ACTR10	7.86606877632346
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	30/502	138/9376	4.06028061666378	MT-ND3/MT-ND4/MT-CYB/MT-CO2/MT-ATP6/MT-CO3/MT-ND5/MT-ND2/MT-CO1/MT-ND1/MT-ND6/ATP5F1E/ATP5F1B/MT-ND4L/NDUFA6/COX4I1/ATP5MC2/NDUFA12/ATP6V1F/COX7C/NDUFA1/NDUFA4/COX5B/ATP5F1A/SDHA/COX7A2L/COX7A2/NDUFB5/UQCR10/ATP5MG	8.61369719134116
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	52/502	388/9376	2.50314207089169	MT-ND3/MT-ND4/GAPDH/MT-CYB/MT-CO2/TUBA1B/MT-ATP6/MT-CO3/MT-ND5/MT-ND2/MT-CO1/TUBB/TUBB4B/MT-ND1/TUBA1A/PSMB6/MT-ND6/ATP5F1E/ATP5F1B/RB1CC1/CALM1/MT-ND4L/NDUFA6/PSMB3/COX4I1/ATP5MC2/NDUFA12/PSMC3/TUBB6/PSMC2/ADAM10/SEM1/COX7C/PSMB2/NCSTN/NDUFA1/NDUFA4/COX5B/ATP5F1A/SDHA/COX7A2L/CAPN2/COX7A2/NDUFB5/UQCR10/PSMB7/PSMA4/PSMB1/PSMD2/EIF2AK2/APP/CTNNB1	7.19220645987496
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	37/502	235/9376	2.94067983385607	MT-ND3/ACTB/MT-ND4/MT-CYB/MT-CO2/MT-ATP6/ACTG1/MT-CO3/MT-ND5/MT-ND2/MT-CO1/MT-ND1/GNAS/MT-ND6/ATP5F1E/ATP5F1B/MT-ND4L/NDUFA6/COX4I1/ATP5MC2/NDUFA12/RPS6/COX7C/NDUFA1/NDUFA4/COX5B/PRKG1/ATP5F1A/SDHA/COA1/COX7A2L/PPARG/CREB3L2/COX7A2/NDUFB5/UQCR10/ATP5MG	7.16586718063849
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	36/502	227/9376	2.96203731330186	MT-ND3/MT-ND4/MT-CYB/MT-CO2/MT-ATP6/MT-CO3/MT-ND5/MT-ND2/MT-CO1/FOS/SOD1/MT-ND1/MT-ND6/ATP5F1E/ATP5F1B/PLD1/MT-ND4L/NDUFA6/COX4I1/ATP5MC2/HMOX1/NDUFA12/PRKD3/MGST3/COX7C/NDUFA1/NDUFA4/COX5B/ATP5F1A/SDHA/COX7A2L/PRKD1/COX7A2/NDUFB5/UQCR10/GSTO1	7.11723263956299
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	57/502	480/9376	2.21792828685259	MT-ND3/MT-ND4/MT-CYB/MT-CO2/TUBA1B/MT-ATP6/MT-CO3/MT-ND5/MT-ND2/MT-CO1/TUBB/UBB/TUBB4B/SOD1/HSPA5/MT-ND1/TUBA1A/PSMB6/MT-ND6/ATP5F1E/ATP5F1B/RB1CC1/CALM1/MT-ND4L/NDUFA6/PSMB3/COX4I1/ATP5MC2/NDUFA12/PARK7/PSMC3/TUBB6/PSMC2/UBC/SEM1/COX7C/PSMB2/NDUFA1/NDUFA4/COX5B/ATP5F1A/SDHA/COX7A2L/CAPN2/COX7A2/RPS27A/NDUFB5/UQCR10/UBA52/PSMB7/PSMA4/PSMB1/PSMD2/ACTR10/UBE2L6/APP/CTNNB1	6.5151247125597
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	32/502	205/9376	2.9154795452337	MT-ND3/MT-ND4/GAPDH/MT-CYB/MT-CO2/MT-ATP6/MT-CO3/MT-ND5/MT-ND2/MT-CO1/MT-ND1/MT-ND6/ATP5F1E/ATP5F1B/MT-ND4L/NDUFA6/COX4I1/TGFBR2/ATP5MC2/NDUFA12/COX7C/NDUFA1/NDUFA4/COX5B/ATP5F1A/SDHA/COX7A2L/PPP1CA/TBC1D4/COX7A2/NDUFB5/UQCR10	6.59513799499799
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	30/502	203/9376	2.76019076403745	ACTB/ACTG1/FN1/THBS1/ITGB1/EMP1/CAV1/MYL12A/LAMB2/ITGB4/VWF/FLNB/COL6A2/CCND1/MYL12B/KDR/COL4A1/CDC42/COL6A1/ACTN4/CAV2/ITGAV/DIAPH1/ILK/LAMC2/RAP1A/PPP1CA/LAMC1/CAPN2/CTNNB1	6.03017401116616
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	24/502	142/9376	3.15672521182874	ACTB/ACTG1/CAV1/HSP90B1/HSP90AB1/FOS/CTSL/SDC4/CALM1/EDN1/KDR/MAPK7/PECAM1/HMOX1/MGST3/GSTP1/CAV2/ITGAV/TXN/CCL2/GSTO1/CDH5/SUMO2/CTNNB1	6.15916497390767
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	27/502	174/9376	2.89820030223932	HSP90B1/HSP90AB1/HSPA8/HSPA5/HERPUD1/RBX1/OS9/BCAP31/CALR/RPN1/SKP1/SEC61B/SEC61A1/TUSC3/LMAN2/DNAJC3/UBXN4/CANX/DNAJA1/SEC62/OSTC/RRBP1/DDOST/CAPN2/TRAM1/HSPH1/PDIA4	6.01109141253689
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	24/502	155/9376	2.8919676134173	HLA-C/ACTB/TUBA1B/ACTG1/THBS1/ITGB1/TUBB/TUBB4B/CTSL/TUBA1A/CALR/SEC61B/SEC61A1/HLA-A/CTSS/LAMP1/CANX/MRC1/TUBB6/ATP6V1F/ITGAV/MSR1/LAMP2/STX7	5.64895767209829
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	31/502	233/9376	2.4849614417865	ACTB/ACTG1/VIM/FN1/MYH9/THBS1/ITGB1/TPM4/TPM3/SDC4/ITGB4/SPTAN1/AGRN/COL6A2/SUN2/ENO1/PDLIM1/ATP1B3/COL4A1/AMPD1/HSPG2/COL6A1/SDC3/FLNC/ITGAV/DIAPH1/CAPZA1/LMNA/DAG1/MYH10/PLEC	5.45916929160509
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	16/502	78/9376	3.83123914598018	ACTB/ACTG1/FN1/ITGB1/CAV1/ARHGAP10/CDC42/CTTN/ARPC3/WASF2/CAV2/ARPC2/ILK/ARPC1B/CTNNA1/CTNNB1	5.97182220683537
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	32/502	248/9376	2.40997301118108	ACTB/S100A10/GAPDH/ANXA2/TUBA1B/ACTG1/HSP90B1/HSP90AB1/TUBB/FOS/TUBB4B/MYL12A/TUBA1A/MYL12B/AHNAK/RPS3/SKP1/CDC42/ARF1/TUBB6/DYNLL1/ARPC3/PODXL/ARPC2/GCC2/TXN/ABI1/ARPC1B/KPNA4/ACTR10/TNFRSF10B/CTNNB1	5.35212945029269
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	12/502	46/9376	4.87233673999654	PSME1/PSMB6/PSMB3/PSMC3/POMP/PSMC2/SEM1/PSMB2/PSMB7/PSMA4/PSMB1/PSMD2	6.26165297785752
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	19/502	116/9376	3.0592114301415	ACTB/ACTG1/ITGB1/CD99/MYL12A/MYL12B/CDC42/GNAI2/PECAM1/MSN/ACTN4/F11R/RAP1A/CTNND1/CD99L2/RAPGEF4/CTNNA1/CDH5/CTNNB1	5.30764938193316
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	16/502	89/9376	3.35771520658937	FN1/THBS1/ITGB1/SDC4/LAMB2/ITGB4/VWF/AGRN/COL6A2/COL4A1/HSPG2/COL6A1/ITGAV/LAMC2/LAMC1/DAG1	5.31528321079897
NA	NA	hsa04518	Integrin signaling	22/502	154/9376	2.6681844052362	ACTB/ACTG1/FN1/THBS1/ITGB1/LAMB2/ITGB4/VWF/FLNB/COL6A2/LIMS1/CCND1/KDR/COL4A1/CDC42/COL6A1/ACTN4/ITGAV/ILK/LAMC2/LAMC1/CTNNB1	4.96443287620149
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	23/502	170/9376	2.52692758378252	ACTB/TUBA1B/ACTG1/MYH9/ITGB1/MYL12A/TUBA1A/MYL6/DLG2/CCND1/MYL12B/CDC42/MSN/CTTN/PRKCE/ARPC3/ACTN4/F11R/ARPC2/ARPC1B/RAP1A/PPP2R1A/MYH10	4.77842969526426
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	25/502	200/9376	2.33466135458167	ACTB/GAPDH/TUBA1B/ACTG1/MYH9/ITGB1/TUBB/FOS/TUBB4B/TUBA1A/RPS3/TMBIM6/CDC42/ARF1/CTTN/TUBB6/ARPC3/WASF2/ARPC2/ABI1/BAIAP2L1/ARPC1B/MYH10/MYO1C/TNFRSF10B	4.53771447575734
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	34/502	333/9376	1.90699065599464	HLA-C/FN1/THBS1/ITGB1/ISG15/LAMB2/ITGB4/VWF/GNAS/COL6A2/DLG2/CCND1/PKM/BCAP31/COL4A1/CDC42/HLA-A/MX1/MDM2/COL6A1/ATP6V1F/ITGAV/JAG1/LAMC2/CREB3L2/LAMC1/RB1/PPP2R1A/HDAC2/STAT1/EIF2AK2/CTNNB1/PPP2R3A/PPP2R5A	4.00817291330817
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	24/502	204/9376	2.19732833372393	ACTB/DDX5/ACTG1/FN1/THBS1/ITGB1/CAV1/CTSL/SDC4/CD63/CCND1/KDR/TIMP3/CDC42/HSPG2/MSN/RPS6/MDM2/CTTN/CAV2/ITGAV/LUM/PPP1CA/CTNNB1	4.11219882913094
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	13/502	82/9376	2.96103391312798	HLA-C/HSP90AB1/HSPA8/CTSL/HSPA5/PSME1/CALR/HLA-A/CTSS/CANX/B2M/KLRD1/KLRC1	4.24197867475834
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	14/502	93/9376	2.81163517971126	ACTB/ACTG1/MYL12A/MYL12B/CDC42/TGFBR2/ACTN4/WASF2/RAP1A/CTNND1/CTNNA1/CDH5/CTNNB1/PDCD10	4.17585902998167
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	13/502	87/9376	2.79085955030453	MT-CYB/MT-CO2/MT-CO3/MT-CO1/TPM4/TPM3/ATP1B3/COX4I1/COX7C/COX5B/COX7A2L/COX7A2/UQCR10	3.99130077771945
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	19/502	157/9376	2.26030908214277	MT-CYB/MT-CO2/MT-CO3/MT-CO1/FOS/NDUFA6/CDC42/COX4I1/NDUFA12/COX7C/NDUFA1/NDUFA4/COX5B/SDHA/COX7A2L/PPARG/COX7A2/NDUFB5/UQCR10	3.78758832516807
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	34/502	362/9376	1.75422068631551	CSH1/FN1/THBS1/ITGB1/HSP90B1/HSP90AB1/LAMB2/ITGB4/VWF/COL6A2/CSH2/CCND1/KDR/COL4A1/YWHAZ/GNG11/RPS6/MDM2/COL6A1/EFNA5/ANGPT2/ITGAV/YWHAB/LAMC2/CREB3L2/GNG5/LAMC1/DDIT4/YWHAG/PPP2R1A/YWHAQ/CDC37/PPP2R3A/PPP2R5A	3.48074119161959
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	7/502	31/9376	4.21745276956689	SRP14/HSPA5/SEC61B/SEC61A1/SEC62/SPCS2/SPCS1	4.26757496806203
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	26/502	253/9376	1.91940538242288	ACTB/ACTG1/ITGB1/UBB/MYL12A/MYL12B/RBX1/CAPNS1/SKP1/CDC42/ARF1/MDM2/CTTN/PRKCE/UBC/BCL10/ARPC3/ACTN4/WASF2/ARPC2/DIAPH1/ILK/ARPC1B/CAPN2/RPS27A/UBA52	3.52595081321287
NA	NA	hsa04517	IgSF CAM signaling	29/502	299/9376	1.81150981358846	ACTB/TUBA1B/ACTG1/MYH9/ITGB1/TUBB/TUBB4B/MYL12A/SPTAN1/ROBO4/PMP22/TUBA1A/MYL6/MYL12B/KDR/CDC42/MSN/TUBB6/DYNLL1/ARPC3/ACTN4/F11R/ARPC2/ARPC1B/RAP1A/NCAM1/MYH10/APP/CTNNB1	3.39184491738446
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	5/502	17/9376	5.49332083430982	MYH9/LAMP1/DAG1/MYH10/LAMP2	4.410166145103
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	25/502	250/9376	1.86772908366534	HLA-C/CAV1/HSPA8/EHD2/SH3GL2/PLD1/ARRB1/CDC42/ARF1/HLA-A/TGFBR2/MDM2/ARPC3/CAV2/ARPC2/VPS29/ARFGEF1/ARF4/ARPC1B/AP2M1/EHD1/CAPZA1/WWP1/PDCD6IP/CHMP5	3.30743799105298
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	23/502	232/9376	1.85162797087512	ACTB/ACTG1/FN1/MYH9/ITGB1/GSN/MYL12A/ITGB4/CFL1/MYL12B/CDC42/MSN/ARPC3/ACTN4/WASF2/SSH1/ARPC2/ITGAV/DIAPH1/ARPC1B/PPP1CA/MYH10/ABI2	3.12394648320752
NA	NA	hsa03272	Virion - Hepatitis viruses	8/502	48/9376	3.1128818061089	CD9/CD63/CD81/LAMP1/HSPG2/TGOLN2/PDCD6IP/LAMP2	3.49043325726619
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	20/502	196/9376	1.90584600374014	HLA-C/FOS/UBB/ZFP36/CCND1/RCAN1/CALM1/IL6ST/GNG11/HLA-A/UBC/NFATC1/ANGPT2/GNG5/RB1/RPS27A/UBA52/STAT1/EIF2AK2/CTNNB1	3.04816766928888
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	13/502	108/9376	2.24819241552309	EEF1A1/RAN/MAGOH/KPNB1/SRRM1/UPF3A/SAP18/UBE2I/PNN/TPR/KPNA4/XPO4/SUMO2	3.10297437485963
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	8/502	51/9376	2.9297711116319	ACTB/ACTG1/GNAS/SEC61B/SEC61A1/ARF1/ATP6V1F/PDIA4	3.28658034129809
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	12/502	101/9376	2.2190840598004	FN1/SERPINE1/CCND1/EDN1/COL4A1/CDC42/TGFBR2/PRKCE/NFATC1/DIAPH1/CCL2/STAT1	2.92964612738615
Cellular Processes	Cell motility	hsa04814	Motor proteins	19/502	194/9376	1.82921920565162	ACTB/TUBA1B/ACTG1/MYH9/TUBB/TPM4/TUBB4B/MYL12A/TPM3/TUBA1A/MYL6/MYL12B/TUBB6/DYNLL1/KIF13B/CAPZA1/MYH10/ACTR10/MYO1C	2.77574366698272
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	16/502	158/9376	1.8913712239649	CCND1/RBX1/YWHAZ/SKP1/MDM2/YWHAB/GADD45B/BUB3/RB1/YWHAG/PPP2R1A/HDAC2/CDC25B/YWHAQ/PPP2R5A/RAD21	2.68748832251856
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	6/502	37/9376	3.02874986540325	TPM3/CCND1/GADD45B/PPARG/TPR/CTNNB1	2.94074226203404
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	15/502	149/9376	1.88026417818658	MT-ND3/MT-ND4/MT-ND5/MT-ND2/MT-ND1/MT-ND6/MT-ND4L/NDUFA6/GNG11/GNAI2/NDUFA12/NDUFA1/NDUFA4/GNG5/NDUFB5	2.57604643580722
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	19/502	205/9376	1.73106597998251	HLA-C/VIM/ISG15/CCND1/CALR/HLA-A/OAS1/MDM2/PSMC3/PSMC2/SEM1/B2M/OAS2/GADD45B/RB1/HDAC2/STAT1/PSMD2/EIF2AK2	2.51711433485699
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	14/502	137/9376	1.90862826067991	ACTB/TUBA1B/ACTG1/FOS/CTSL/SPTAN1/TUBA1A/CTSS/GADD45B/CAPN2/LMNA/CTSW/PARP4/TNFRSF10B	2.54807275935155
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	11/502	98/9376	2.09643060411416	GSN/CFL1/MARCKS/PLD1/CDC42/PRKCE/PLPP1/ARPC3/WASF2/ARPC2/ARPC1B	2.59504436888161
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	15/502	156/9376	1.79589334967821	CCND1/CD81/YWHAZ/OAS1/MX1/OAS2/YWHAB/RB1/YWHAG/PPP2R1A/IFIT1/STAT1/YWHAQ/EIF2AK2/CTNNB1	2.38412762015521
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	18/502	205/9376	1.63995724419396	HLA-C/GSN/CCND1/PKM/IL6ST/YWHAZ/CDC42/HLA-A/MDM2/ACTN4/YWHAB/CREB3L2/RB1/YWHAG/HDAC2/HNRNPK/YWHAQ/EIF2AK2	2.20342020715383
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	10/502	93/9376	2.0083108426509	FN1/ITGB1/LAMB2/CCND1/COL4A1/ITGAV/LAMC2/GADD45B/LAMC1/RB1	2.32417872233154
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	4/502	23/9376	3.24822449333102	PRCP/LNPEP/ATP6AP2/CTSA	2.56747314883846
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	18/502	212/9376	1.58580771254604	ACTB/ACTG1/THBS1/ITGB1/GNAS/RASGRP3/CALM1/KDR/CDC42/GNAI2/PRKD3/EFNA5/ANGPT2/RAP1A/PRKD1/CTNND1/RAPGEF4/CTNNB1	2.0519097728683
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	10/502	99/9376	1.88659503400539	ACTB/ACTG1/ITGB1/TPM4/TPM3/ITGB4/EDN1/ITGAV/LMNA/DAG1	2.10919580060473
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	9/502	86/9376	1.95460020383582	ACTB/ACTG1/ITGB1/ITGB4/ITGAV/LMNA/DAG1/CTNNA1/CTNNB1	2.11514758591525
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	14/502	157/9376	1.66549090263151	HLA-C/SERPINE1/CCND1/CALM1/HLA-A/TGFBR2/MDM2/ZFP36L1/TRPM7/NFATC1/GADD45B/PPP1CA/CAPN2/RB1	1.99999000961507
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	14/502	157/9376	1.66549090263151	ACTB/ACTG1/SERPINE1/DLG2/CCND1/YWHAZ/TGFBR2/YWHAB/PPP1CA/YWHAG/PPP2R1A/CTNNA1/YWHAQ/CTNNB1	1.99999000961507
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	8/502	75/9376	1.99224435590969	HSP90B1/HSPA5/GNAS/CGA/ATP1B3/CANX/CREB3L2/PDIA4	2.05192853649765
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	20/502	250/9376	1.49418326693227	HYAL2/PSAP/CTSL/OSBPL3/CD63/CTSS/LAMP1/LAMTOR5/OSBPL5/ATP6V1F/LAPTM5/VPS29/AP2M1/CTSA/CTSW/CD164/GNS/LAMP2/STX17/LAMTOR2	1.88362997433522
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	14/502	160/9376	1.63426294820717	HLA-C/CD34/ITGB1/CD99/SDC4/PECAM1/HLA-A/NRXN3/SDC3/F11R/ITGAV/NCAM1/CD99L2/CDH5	1.92457962972406
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	9/502	89/9376	1.88871480370652	TUBA1B/TUBB/TUBB4B/GNAS/TUBA1A/MAPK7/GNAI2/TUBB6/PRKG1	2.0035375189199
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	10/502	103/9376	1.81332920744208	MAGOH/SRRM1/UPF3A/SAP18/PNN/PPP1CA/PPP2R1A/CSTF3/PPP2R3A/PPP2R5A	1.97402494126495
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	12/502	133/9376	1.68516909804391	FOS/GNAS/CALM1/ARRB1/GNG11/GNAI2/PPP1CA/CREB3L2/GNG5/PPP2R1A/PPP2R3A/PPP2R5A	1.8927571528043
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	10/502	105/9376	1.7787896034908	ACTB/ACTG1/ITGB1/TPM4/TPM3/ITGB4/GNAS/ITGAV/LMNA/DAG1	1.90866315013198
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	12/502	134/9376	1.67259320925254	MYH9/CALCRL/GNAS/MYL6/CALM1/EDN1/CALD1/PRKCE/ADM/PRKG1/PPP1CA/MYH10	1.8650895118326
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	15/502	180/9376	1.55644090305445	HLA-C/SRSF3/CALR/HLA-A/OAS1/BST2/SRSF5/B2M/SRSF7/OAS2/SRSF6/CCL2/PPP1CA/STAT1/EIF2AK2	1.79280726160226
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	11/502	122/9376	1.68401802625563	ACTB/ACTG1/CCND1/RCAN1/ATP1B3/MDM2/ITGAV/TBC1D4/HDAC2/STAT1/CTNNB1	1.80867484878266
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	12/502	138/9376	1.62411224666551	ACTB/ACTG1/FN1/ITGB1/FOS/CDC42/ARPC3/WASF2/NFATC1/ARPC2/CCL2/ARPC1B	1.75667351448476
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	5/502	41/9376	2.27771839471383	THBS1/DAPK1/CCND1/MDM2/RB1	1.950058764789
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	14/502	169/9376	1.54723119356892	UBB/CTSL/DAPK1/RB1CC1/LAMP1/UBC/TAX1BP1/RPS27A/DDIT4/UBA52/LAMP2/STX17/GABARAPL1/STX7	1.70739069642303
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	13/502	154/9376	1.57665442127594	TPM4/TPM3/GNAS/CALM1/ATP1B3/GNAI2/PPP1CA/CREB3L2/ATP2B4/PPP2R1A/RAPGEF4/PPP2R3A/PPP2R5A	1.71609455058049
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	13/502	154/9376	1.57665442127594	ACTB/ACTG1/FOS/GNAS/MYL6/CCND1/RCAN1/CALM1/EEF2/MAPK7/GNAI2/NFATC1/PPP1CA	1.71609455058049
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	14/502	170/9376	1.53812983360675	ACTB/ACTG1/CCND1/TXNRD2/TGFBR2/HMOX1/MGST3/GSTP1/GADD45B/TXNRD1/RB1/PBRM1/GSTO1/CTNNB1	1.68404553308558
Organismal Systems	Immune system	hsa04611	Platelet activation	11/502	126/9376	1.63055713653323	ACTB/ACTG1/ITGB1/MYL12A/VWF/GNAS/MYL12B/GNAI2/PRKG1/RAP1A/PPP1CA	1.69479290058827
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	7/502	69/9376	1.89479762110976	FOS/GNAS/CALM1/FOSB/PPP1CA/CREB3L2/HDAC2	1.77428055841372
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	7/502	70/9376	1.86772908366534	HLA-C/ACTB/ACTG1/CAV1/CCND1/HLA-A/DAG1	1.73312319425332
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	5/502	44/9376	2.12241941325607	RPN1/MAN2A1/TUSC3/OSTC/DDOST	1.77489198142751
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	11/502	130/9376	1.58038614771683	FOS/GNAS/EDN1/ARRB1/COL4A1/GNG11/GNAI2/TGFBR2/EDNRB/CREB3L2/GNG5	1.58485507403004
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	17/502	224/9376	1.41747296528173	HLA-C/FOS/ZFP36/CCND1/FDPS/CALR/TSPO/RAN/HLA-A/TGFBR2/CANX/NFATC1/B2M/BUB3/CREB3L2/RB1/CRTC3	1.50408418466776
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	6/502	59/9376	1.89938550881221	GGT5/MGST3/GSTP1/LAP3/GSTO1/PRDX6	1.64820652250032
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	7/502	73/9376	1.79097309392567	PPIA/MAP1B/RAN/BST2/MX1/PDCD6IP/NELFE	1.61357595958858
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	4/502	33/9376	2.26391404080647	BET1/VAMP5/STX17/STX7	1.72985267920298
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	17/502	227/9376	1.39873984239254	HLA-C/GNAS/CCND1/CALM1/CALR/GNG11/GNAI2/HLA-A/MDM2/NFATC1/B2M/ITGAV/CCL2/CREB3L2/GNG5/RB1/CTNNB1	1.44641704912051
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	7/502	75/9376	1.74321381142098	THBS1/SESN3/SERPINE1/CCND1/MDM2/GADD45B/TNFRSF10B	1.5369416004143
Organismal Systems	Digestive system	hsa04978	Mineral absorption	6/502	61/9376	1.83711057409705	MT2A/ATP1B3/HMOX1/TRPM7/FTL/ATP2B4	1.56003413165681
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	7/502	77/9376	1.69793553060485	CCND1/PLD1/CDC42/TGFBR2/GADD45B/RB1/STAT1	1.46258236058432
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	7/502	77/9376	1.69793553060485	CCND1/BCR/TGFBR2/MDM2/GADD45B/RB1/HDAC2	1.46258236058432
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	11/502	138/9376	1.48876955944339	RBX1/CALM1/YWHAZ/SKP1/YWHAB/PPP1CA/YWHAG/PPP2R1A/YWHAQ/CPEB4/PPP2R5A	1.3757277546594
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	3/502	23/9376	2.43616836999827	FDPS/PCYOX1/ACAT1	1.6401047751768
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	5/502	50/9376	1.86772908366534	THBS1/CD81/PECAM1/GYPC/CCL2	1.46318498266761
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	9/502	110/9376	1.52814197754437	GAPDH/SERPINE1/ENO1/RBX1/EDN1/HMOX1/RPS6/ANGPT2/PGK1	1.32519157599836
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	11/502	142/9376	1.44683238875484	UBB/RBX1/SKP1/MDM2/UBC/UBE2I/MID1/RPS27A/UBA52/WWP1/UBE2L6	1.27606168042739
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	11/502	144/9376	1.42673749446658	PSMB6/RB1CC1/PSMB3/PSMC3/PSMC2/SEM1/PSMB2/PSMB7/PSMA4/PSMB1/PSMD2	1.22735991607742
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	8/502	98/9376	1.52467680299211	GNAS/CALM1/ATP1B3/PRKCE/PRKD3/PRKD1/CREB3L2/ATP2B4	1.24181099832355
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	5/502	56/9376	1.66761525327262	RPN1/MAN2A1/TUSC3/OSTC/DDOST	1.1917635338128
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	8/502	103/9376	1.45066336595366	PRCP/COL18A1/COL8A1/COL6A2/ATP1B3/COL4A1/COL6A1/SLC38A2	1.09380152140952
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	8/502	103/9376	1.45066336595366	FOS/SERPINE1/GNAS/CALR/GNAI2/TGFBR2/CCL2/PPP2R1A	1.09380152140952
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	8/502	103/9376	1.45066336595366	FN1/PRDX1/LAMB2/GNAS/COL4A1/ACTN4/LAMC2/LAMC1	1.09380152140952
NA	NA	hsa04382	Cornified envelope formation	15/502	217/9376	1.29105697027558	S100A10/S100A6/ITGB4/KRT18/S100A4/S100A11/COL4A1/LAMC2/ELOVL1/S100A13/SPTLC2/PPP2R1A/PLEC/PPP2R3A/PPP2R5A	1.03171946981872
Human Diseases	Infectious disease: viral	hsa05162	Measles	10/502	136/9376	1.37333020857745	HSPA8/FOS/CCND1/OAS1/RACK1/MSN/MX1/OAS2/STAT1/EIF2AK2	1.04304821957754
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	7/502	89/9376	1.46900040288285	GLUL/GNG11/GNAI2/GLS/GNG5/SLC38A2/GABARAPL1	1.0573244640973
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	8/502	105/9376	1.42303168279264	UBB/UBC/TAX1BP1/USP15/RPS27A/UBA52/GABARAPL1/TOMM20	1.03676908457108
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	8/502	106/9376	1.40960685559648	HSP90B1/HSP90AB1/CCND1/MDM2/GSTP1/CREB3L2/RB1/CTNNB1	1.00869081672843
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	5/502	59/9376	1.58282125734351	CCND1/ILK/GADD45B/CTNNA1/CTNNB1	1.06807346615363
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	4/502	44/9376	1.69793553060485	GNAS/DYNLL1/ARHGDIA/CREB3L2	1.10365177418871
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	10/502	139/9376	1.34368998824844	HSP90B1/HSP90AB1/HSPA8/FOS/KRT18/GNAS/CALM1/GNAI2/CREB3L2/FKBP5	0.970927035366307
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	6/502	75/9376	1.49418326693227	GAPDH/GLUL/ENO1/PKM/PGAM1/PGK1	1.02195466433094
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	4/502	45/9376	1.66020362992475	HLA-C/HLA-A/KLRD1/KLRC1	1.05583937658221
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	11/502	157/9376	1.30859999492476	THBS1/S1PR1/BSG/CALR/PECAM1/ADAM10/NFATC1/ITGAV/PPARG/ADAM9/ANO6	0.927431020283276
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	6/502	76/9376	1.47452296078843	ACTB/ACTG1/GNAS/CALM1/ATP1B3/GNAI2	0.987871230928727
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	9/502	125/9376	1.34476494023904	S1PR1/PLD1/GNAI2/PRKCE/ORMDL1/SPTLC2/PPP2R1A/PPP2R3A/PPP2R5A	0.922914662660734
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	15/502	226/9376	1.23964319712301	FOS/GNAS/CGA/CALM1/PLD1/EDN1/ATP1B3/GNAI2/NFATC1/RAP1A/PPP1CA/CREB3L2/ATP2B4/RAPGEF4/PDE4B	0.867334380966308
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/502	17/9376	2.19732833372393	TXNRD2/TXNRD1	1.17517023081058
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	8/502	110/9376	1.35834842448388	THBS1/RBX1/LTBP1/SKP1/TGFBR2/THSD4/PPP2R1A/HDAC2	0.899152753595379
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	7/502	94/9376	1.39086208358057	HSP90B1/HSP90AB1/FOS/MAPK7/FOSB/CCL2/USP25	0.905825353474961
NA	NA	hsa04519	Cadherin signaling	25/502	404/9376	1.15577294781271	ACTB/CDH13/ACTG1/VIM/KRT18/KDR/YWHAZ/CDC42/ARPC3/ACTN4/ADAM10/ARPC2/NCSTN/YWHAB/ARPC1B/CTNND1/PPP1CA/PCDH12/YWHAG/ABI2/CTNNA1/YWHAQ/MYO1C/CDH5/CTNNB1	0.761229960911626
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	14/502	214/9376	1.22187883978106	HLA-C/FOS/CFL1/RBX1/CALM1/CALR/SKP1/GNG11/GNAI2/HLA-A/BST2/NFATC1/B2M/GNG5	0.78091796485028
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	7/502	97/9376	1.34784573048014	FOS/GNAS/CALM1/GNG11/GNAI2/PRKG1/GNG5	0.819029871347251
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	4/502	49/9376	1.52467680299211	GALNT18/GALNT1/COLGALT1/FUT11	0.87578338123602
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	4/502	49/9376	1.52467680299211	GNAS/GNAI2/FOSB/CREB3L2	0.87578338123602
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/502	19/9376	1.96603061438457	HYAL2/GNS	1.00248333125039
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	14/502	217/9376	1.20498650559054	HSP90B1/HSP90AB1/FOS/GNAS/CCND1/ARRB1/GNAI2/KPNB1/MGST3/JAG1/CREB3L2/RB1/KPNA4/GSTO1	0.726622587556045
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	3/502	34/9376	1.64799625029295	RBX1/SKP1/NR1D1	0.900263835413333
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	8/502	116/9376	1.28808902321748	GAPDH/ENO1/PKM/SDHA/PGAM1/PGK1/ESD/ACAT1	0.74255392313789
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	8/502	116/9376	1.28808902321748	GLUL/GNAS/PLD1/GNG11/GNAI2/GLS/GNG5/SLC38A2	0.74255392313789
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	5/502	67/9376	1.39382767437712	GAPDH/ENO1/PKM/PGAM1/PGK1	0.769431392975341
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/502	20/9376	1.86772908366534	UGP2/CYB5R3	0.923914599484493
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	7/502	101/9376	1.29446570155023	GNAS/CALM1/EDN1/GNAI2/EDNRB/CREB3L2/CTNNB1	0.707646281861757
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	4/502	52/9376	1.43671467974257	GNAS/CGA/HSD17B2/HSD17B7	0.751062562284625
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	3/502	36/9376	1.55644090305445	GALNT18/GALNT1/ST3GAL2	0.795563122437271
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/502	21/9376	1.7787896034908	CHSY3/CSGALNACT1	0.849739254333887
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4/502	53/9376	1.40960685559648	GNAS/ATP1B3/AP2M1/ATP2B4	0.711221855942163
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	3/502	37/9376	1.51437493270163	GLUL/GLS/RIMKLB	0.745604043614278
Genetic Information Processing	Transcription	hsa03040	Spliceosome	15/502	243/9376	1.15291918744774	DDX5/HSPA8/SRSF3/MAGOH/SNRPA/SRSF5/SRSF7/PCBP1/TRA2B/SNRPF/SRSF6/SNRPG/SNRPB/TRA2A/HNRNPK	0.574428758126438
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	11/502	173/9376	1.18757340579877	ACTB/ACTG1/FDPS/DNAJC3/OAS1/MX1/OAS2/CCL2/STAT1/EIF2AK2/TNFRSF10B	0.592253163497034
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	8/502	122/9376	1.22474038273137	FOS/CDC42/BCL10/NFATC1/CARD11/PPP2R1A/PPP2R3A/PPP2R5A	0.594256674750419
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	8/502	122/9376	1.22474038273137	CSH1/FOS/GNAS/CSH2/GNAI2/CREB3L2/SOCS2/STAT1	0.594256674750419
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	5/502	71/9376	1.31530217159531	FOS/CGA/CCND1/SOCS2/STAT1	0.63427228078205
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	9/502	140/9376	1.20068298235629	SERPINE1/CCND1/CALM1/GNG11/GNAI2/RPS6/PRKCE/JAG1/GNG5	0.568997537370872
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/502	23/9376	1.62411224666551	GLUL/GLS	0.712736401515138
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/502	23/9376	1.62411224666551	ATP1B3/GLS	0.712736401515138
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	6/502	91/9376	1.23146972549363	FOS/RASGRP3/CD81/BCL10/NFATC1/CARD11	0.527717775777894
Human Diseases	Substance dependence	hsa05032	Morphine addiction	6/502	91/9376	1.23146972549363	GNAS/ARRB1/GNG11/GNAI2/GNG5/PDE4B	0.527717775777894
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	4/502	57/9376	1.31068707625638	HSD17B12/ELOVL1/ACAT1/CBR4	0.559569126316596
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	10/502	163/9376	1.14584606359837	FOS/YWHAZ/TGFBR2/HSPG2/NFATC1/YWHAB/CREB3L2/RB1/STAT1/YWHAQ	0.446751236458638
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	6/502	93/9376	1.20498650559054	GNAS/CGA/CALM1/PLD1/CDC42/MAPK7	0.472498414681413
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	5/502	76/9376	1.22876913399035	FABP5/UBC/ILK/PPARG/DBI	0.476256081724808
Human Diseases	Cancer: specific types	hsa05214	Glioma	5/502	76/9376	1.22876913399035	CCND1/CALM1/MDM2/GADD45B/RB1	0.476256081724808
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	4/502	59/9376	1.26625700587481	GNAS/CGA/GNAI2/PRKG1	0.487940409806949
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	3/502	42/9376	1.3340922026181	HMOX1/PCBP1/FTL	0.516101202850384
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	7/502	112/9376	1.16733067729084	ITGB1/HSPA8/LAMB2/GNAI2/LAMC2/LAMC1/STAT1	0.423704514775551
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	10/502	166/9376	1.12513800220804	CALM1/ATP1B3/GNAI2/EDNRB/PRKCE/NFATC1/PRKG1/PPP1CA/CREB3L2/ATP2B4	0.386893319505722
Organismal Systems	Nervous system	hsa04730	Long-term depression	4/502	60/9376	1.24515272244356	GNAS/GNAI2/PRKG1/PPP2R1A	0.453080520056016
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	5/502	78/9376	1.19726223311881	ITGB1/FOS/CFL1/CALM1/GNAI2	0.416077527743067
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	10/502	168/9376	1.11174350218175	HSP90AB1/GLUL/PPIA/TRPM7/FTL/CAPN2/STAT1/EIF2AK2/TNFRSF10B/CHMP5	0.347593821876391
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	7/502	115/9376	1.13687857266586	FOS/GNAS/PLD1/ARRB1/GNAI2/CREB3L2/PDE4B	0.351263666751021
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	3/502	44/9376	1.27345164795364	HLA-C/HLA-A/ICA1	0.432411566949909
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/502	10/9376	1.86772908366534	SQOR	0.65295742056023
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	2/502	27/9376	1.38350302493729	HSD17B12/ELOVL1	0.47461983130864
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	7/502	117/9376	1.11744475091089	ACTB/ACTG1/MORF4L2/MORF4L1/YY1/HDAC2/PBRM1	0.304034091879822
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	6/502	99/9376	1.13195702040324	FOS/GNAS/CCND1/MDM2/JAG1/RB1	0.313923699794967
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	6/502	99/9376	1.13195702040324	FOS/PLD1/DGKH/PLPP1/WASF2/SLC44A2	0.313923699794967
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	2/502	28/9376	1.3340922026181	HSD17B12/ELOVL1	0.421079199019852
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	5/502	83/9376	1.12513800220804	AUTS2/SKP1/YY1/HDAC2/JARID2	0.272350438912246
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	3/502	47/9376	1.19216750021192	PKM/PRKCE/SOCS2	0.314115312362987
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	4/502	66/9376	1.13195702040324	HSD17B2/HSD17B7/HSD17B11/HSD17B12	0.255862955672114
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	7/502	122/9376	1.07164783488995	CCND1/EEF2/PPARG/CREB3L2/PPP2R1A/PPP2R3A/PPP2R5A	0.189450616739671
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/502	12/9376	1.55644090305445	NCAM1	0.458729586822329
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	12/502	216/9376	1.03762726870297	HSP90B1/HSP90AB1/HSPA8/FOS/HSPA5/CALM1/CDC42/NFATC1/CCL2/RAP1A/PPARG/TNFRSF10B	0.133063706969437
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	5/502	86/9376	1.08588900213101	GNAS/ATP1B3/PCLO/CREB3L2/RAPGEF4	0.190307853260549
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	2/502	31/9376	1.20498650559054	GLUL/ACAT1	0.271890636071857
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	5/502	87/9376	1.0734075193479	FOS/CCND1/TGFBR2/GADD45B/CTNNB1	0.16360383426712
Organismal Systems	Endocrine system	hsa04924	Renin secretion	4/502	69/9376	1.08274149777701	GNAS/CALM1/EDN1/GNAI2	0.164066854243199
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/502	13/9376	1.43671467974257	XRCC5	0.37474835884815
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/502	51/9376	1.09866416686196	PLD1/PLPP1/PAFAH1B2	0.168034286161984
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	4/502	71/9376	1.05224173727625	CDC42/ADAM10/F11R/ATP6V1F	0.105091207226924
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	6/502	109/9376	1.02810775247633	HSP90AB1/FOS/IL6ST/TGFBR2/NFATC1/STAT1	0.0702016908373487
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/502	14/9376	1.3340922026181	ST3GAL2	0.2975252465674
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	10/502	187/9376	0.998785606238149	TXNIP/HSP90AB1/OAS1/TRPM7/TXN/OAS2/CCL2/STAT1/GABARAPL1/TP53BP1	-0.00398955071100354
Human Diseases	Cancer: specific types	hsa05218	Melanoma	4/502	73/9376	1.02341319652895	CCND1/MDM2/GADD45B/RB1	0.0477626500147313
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	3/502	54/9376	1.03762726870297	HLA-C/CGA/HLA-A	0.0659512163898957
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	5/502	93/9376	1.00415542132545	FOS/NFATC1/JAG1/MAF/STAT1	0.0095783377688812
Organismal Systems	Digestive system	hsa04970	Salivary secretion	5/502	93/9376	1.00415542132545	GNAS/CALM1/ATP1B3/PRKG1/ATP2B4	0.0095783377688812
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/502	15/9376	1.24515272244356	ST3GAL2	0.225995094302813
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	3/502	55/9376	1.01876131836291	PSAP/PLPP1/SPTLC2	0.0331887754266591
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	4/502	75/9376	0.996122177954847	MDM2/MGST3/GSTP1/GSTO1	-0.00801920783576909
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	3/502	56/9376	1.00056915196357	EEF1A1/HSPA8/ARF1	0.00101599619250886
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/502	16/9376	1.16733067729084	ST3GAL2	0.159321879270158
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	4/502	78/9376	0.957809786495045	ENO1/BTG2/NUDT16/DCP1A	-0.0889901703562332
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	4/502	78/9376	0.957809786495045	ITGB1/EEF1A1/FOS/STAT1	-0.0889901703562332
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/502	17/9376	1.09866416686196	GGT5	0.0968382593797717
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/502	17/9376	1.09866416686196	GLUL	0.0968382593797717
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/502	38/9376	0.983015307192283	NNMT/NT5E	-0.0249517117422962
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/502	39/9376	0.957809786495045	HLA-C/HLA-A	-0.0627939975693594
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	6/502	120/9376	0.933864541832669	CALM1/CDC42/MAPK7/ARHGDIA/RAP1A/SH2B3	-0.17341677329319
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/502	18/9376	1.03762726870297	CBR4	0.0380036414031949
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/502	18/9376	1.03762726870297	PRDX1	0.0380036414031949
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	10/502	201/9376	0.929218449584746	DDX5/DUSP6/TGFBR2/TSPAN7/MDM2/MAF/GADD45B/PPARG/ZBTB16/HDAC2	-0.241264180134086
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	7/502	142/9376	0.920711520116716	FOS/TGFBR2/FOSB/NFATC1/PPARG/FOSL2/STAT1	-0.226431640643464
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	15/502	300/9376	0.933864541832669	HSPA8/FOS/DUSP6/RASGRP3/KDR/ARRB1/CDC42/MAPK7/TGFBR2/EFNA5/NFATC1/ANGPT2/RAP1A/GADD45B/CDC25B	-0.276901644433658
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	3/502	62/9376	0.903739879192906	HSPA8/SOD1/HDAC2	-0.180863909804511
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	3/502	62/9376	0.903739879192906	JAG1/NCSTN/HDAC2	-0.180863909804511
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	2/502	41/9376	0.911087357885531	SEM1/SSBP1	-0.135698818905007
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	9/502	184/9376	0.91356313874935	ITGB1/MYL12A/CFL1/MYL12B/CDC42/GNAI2/EFNA5/SSH1/ILK	-0.281631142098769
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	5/502	104/9376	0.897946674839105	PLD1/DGKH/PLPP1/PNPLA6/GPAT3	-0.24890573456086
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	16/502	323/9376	0.925190877357443	VIM/THBS1/CCND1/MARCKS/TIMP3/MAPK7/HMOX1/MDM2/PRKCE/EFNA5/GLS/UBE2I/DDIT4/HDAC2/HNRNPK/CDC25B	-0.325414834474921
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/502	20/9376	0.933864541832669	HSD17B7	-0.0704177334776979
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	5/502	105/9376	0.889394801745399	CALM1/MDM2/BCL10/NFATC1/STAT1	-0.271072013770267
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	4/502	85/9376	0.878931333489571	AMPD1/NT5E/GUK1/NUDT16	-0.266678360436736
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/502	43/9376	0.868711201704809	PLPP1/ACAT1	-0.205224427417465
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	3/502	65/9376	0.862028807845541	DGKH/PLPP1/GPAT3	-0.265475664450467
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	5/502	107/9376	0.872770599843616	GNAS/PKM/CALM1/CREB3L2/PGAM1	-0.314804340665236
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	2/502	44/9376	0.848967765302427	MPG/PARP4	-0.23882864028889
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	3/502	66/9376	0.848967765302427	NFATC1/MAF/STAT1	-0.292849549447222
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	4/502	88/9376	0.848967765302427	TFPI/CLU/VWF/SERPINE1	-0.338553778836668
Human Diseases	Substance dependence	hsa05034	Alcoholism	9/502	191/9376	0.880081767172149	GNAS/CALM1/GNG11/GNAI2/FOSB/PPP1CA/CREB3L2/GNG5/HDAC2	-0.398235624681494
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/502	45/9376	0.830101814962373	ABCA4/ABCA6	-0.271711916811219
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	3/502	67/9376	0.836296604626271	CALM1/RAP1A/PPP1CA	-0.319831590647911
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	3/502	68/9376	0.823998125146473	DUSP6/CCND1/ZBTB16	-0.346434669634839
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/502	46/9376	0.812056123332756	HMOX1/FTL	-0.303909348287873
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	4/502	90/9376	0.830101814962373	SESN3/RB1CC1/PPARG/CREB3L2	-0.385188612244461
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/502	23/9376	0.812056123332756	SSBP1	-0.214631972146524
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	6/502	133/9376	0.842584549021957	S1PR1/CCND1/TGFBR2/MDM2/GADD45B/GABARAPL1	-0.434855018492834
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	6/502	133/9376	0.842584549021957	HLA-C/HLA-A/NFATC1/KLRD1/KLRC1/TNFRSF10B	-0.434855018492834
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	2/502	47/9376	0.794778333474612	PKM/ACAT1	-0.335453538257959
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	7/502	155/9376	0.843490553913379	GNAS/CCND1/GNAI2/RAP1A/CREB3L2/RB1/CTNNB1	-0.467299350135266
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	3/502	70/9376	0.800455321570859	MGST3/GSTP1/GSTO1	-0.398552401879321
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	3/502	70/9376	0.800455321570859	RBX1/CDC42/RAP1A	-0.398552401879321
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	3/502	71/9376	0.789181302957185	PKM/GLS/PGAM1	-0.424089866328201
NA	NA	hsa04081	Hormone signaling	10/502	219/9376	0.852844330440794	CSH1/GNAS/CSH2/CGA/GNG11/GNAI2/ITGAV/PRKG1/GNG5/RAPGEF4	-0.524083194947276
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	5/502	115/9376	0.812056123332756	FOS/GNG11/GNAI2/CREB3L2/GNG5	-0.482309641134975
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	5/502	115/9376	0.812056123332756	GNAS/GNG11/GNAI2/GNG5/APP	-0.482309641134975
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	4/502	95/9376	0.786412245753827	FOS/CTSL/ATP6V1F/CCL2	-0.497643745693867
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3/502	73/9376	0.767559897396714	MGST3/GSTP1/GSTO1	-0.474175119843217
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	3/502	73/9376	0.767559897396714	CCND1/GADD45B/RB1	-0.474175119843217
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	5/502	119/9376	0.784760119187117	FOS/EDN1/JAG1/CCL2/CREB3L2	-0.562003313733023
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/502	27/9376	0.691751512468644	ACAT1	-0.381485505041842
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	2/502	52/9376	0.718357339871284	TSPO/OSBPL5	-0.484369469992681
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	4/502	98/9376	0.762338401496056	CALM1/DGKH/ITPKB/INPP4B	-0.562500162420538
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	4/502	99/9376	0.754638013602157	GNAS/CALM1/PRKCE/PPP1CA	-0.583712350609915
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/502	28/9376	0.66704610130905	DHFR	-0.419644516910755
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/502	28/9376	0.66704610130905	ATP6V1F	-0.419644516910755
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/502	29/9376	0.644044511608738	CALM1	-0.45660047168082
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3/502	79/9376	0.709264208986838	MGST3/GSTP1/GSTO1	-0.617189336048072
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	4/502	102/9376	0.732442777907976	GNAS/ATP1B3/RAP1A/ATP2B4	-0.646191145759848
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/502	30/9376	0.62257636122178	SDHA	-0.492441472182341
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/502	30/9376	0.62257636122178	PIGT	-0.492441472182341
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/502	30/9376	0.62257636122178	DHFR	-0.492441472182341
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	2/502	56/9376	0.66704610130905	CCND1/ARRB1	-0.594357772617636
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	6/502	148/9376	0.757187466350813	FOS/CCND1/JAG1/GADD45B/RB1/CTNNB1	-0.708151125968941
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	6/502	149/9376	0.752105671274633	GNAS/PLD1/ARF1/DGKH/PLPP1/RAPGEF4	-0.725449606827518
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	8/502	193/9376	0.774188221208431	ARRB1/CDC42/GNG11/GNAI2/CCL2/RAP1A/GNG5/STAT1	-0.753894784378789
NA	NA	hsa04981	Folate transport and metabolism	1/502	31/9376	0.602493252795271	DHFR	-0.527246230326177
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	4/502	105/9376	0.71151584139632	BCL10/UBE2I/CARD11/GADD45B	-0.707019046550717
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	6/502	150/9376	0.747091633466135	CCND1/TGFBR2/GADD45B/RB1/CTNNA1/CTNNB1	-0.742642647294917
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	5/502	128/9376	0.729581673306773	AMPD1/NT5E/GUK1/NUDT16/PDE4B	-0.732647344749255
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	3/502	82/9376	0.683315518414148	MGST3/GSTP1/GSTO1	-0.685030895448066
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	10/502	238/9376	0.784760119187117	RASGRP3/CALM1/PLD1/KDR/CDC42/GNG11/EFNA5/ANGPT2/RAP1A/GNG5	-0.799951080121747
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/502	32/9376	0.583665338645418	UGP2	-0.561085347996174
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/502	32/9376	0.583665338645418	GABARAPL1	-0.561085347996174
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	3/502	83/9376	0.675082801324821	PRDX1/SOD1/FAR1	-0.707150027233214
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	3/502	83/9376	0.675082801324821	POLR2L/PCBP1/G3BP1	-0.707150027233214
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	2/502	60/9376	0.62257636122178	KDR/CDC42	-0.697537832068904
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	4/502	109/9376	0.685405168317555	PRKCE/PPP1CA/TBC1D4/CREB3L2	-0.785729457785516
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/502	34/9376	0.549332083430982	POLR2L	-0.626114775949309
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	4/502	110/9376	0.679174212241941	HSP90AB1/GNAI2/CDC25B/CPEB4	-0.805002536016562
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	2/502	63/9376	0.592929867830266	COLGALT1/ACAT1	-0.771032165386781
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	2/502	63/9376	0.592929867830266	RBX1/POLR2L	-0.771032165386781
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/502	63/9376	0.592929867830266	GADD45B/CTNNB1	-0.771032165386781
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	7/502	181/9376	0.722326164953446	CALM1/CTSS/LAMP1/MRC1/BCL10/STAT1/LAMP2	-0.897172934955417
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/502	36/9376	0.518813634351483	UGP2	-0.687969064510193
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/502	36/9376	0.518813634351483	UGP2	-0.687969064510193
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/502	36/9376	0.518813634351483	SSBP1	-0.687969064510193
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	3/502	90/9376	0.62257636122178	FOS/NFATC1/STAT1	-0.855684759769743
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	5/502	138/9376	0.67671343611063	CALM1/RPS6/PRKAR1A/PPP1CA/SOCS2	-0.909946804292734
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/502	37/9376	0.504791644233875	UGP2	-0.71782143533223
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	2/502	65/9376	0.574685871897027	GNAS/CREB3L2	-0.818363232173162
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	2/502	65/9376	0.574685871897027	CGA/ARRB1	-0.818363232173162
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1/502	38/9376	0.491507653596142	UGP2	-0.747011123148995
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/502	38/9376	0.491507653596142	ATP1B3	-0.747011123148995
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/502	39/9376	0.478904893247523	DHFR	-0.775574289591532
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	6/502	168/9376	0.66704610130905	CSH1/CSH2/CCND1/IL6ST/SOCS2/STAT1	-1.03569975788296
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/502	41/9376	0.455543678942766	PGAM1	-0.830951346803009
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/502	42/9376	0.4446974008727	ACAT1	-0.857824089007991
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/502	43/9376	0.434355600852404	ACAT1	-0.884188517560779
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	3/502	100/9376	0.560318725099602	IL6ST/CCL2/TNFRSF10B	-1.05132111002129
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	6/502	178/9376	0.629571601235507	CCND1/RBX1/SKP1/NFATC1/MCC/CTNNB1	-1.18671206415348
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	2/502	78/9376	0.478904893247523	ITPKB/INPP4B	-1.09912556655483
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/502	48/9376	0.389110225763612	ACAT1	-1.00917617746226
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/502	48/9376	0.389110225763612	ATP1B3	-1.00917617746226
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	2/502	79/9376	0.472842805991225	ATP6V1F/AP2M1	-1.11907721243894
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	5/502	158/9376	0.591053507489031	LAMTOR5/RPS6/ATP6V1F/DDIT4/LAMTOR2	-1.23297554779649
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	2/502	80/9376	0.466932270916335	KDR/RPS6	-1.13882531492557
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/502	50/9376	0.373545816733068	LAP3	-1.05634162844194
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/502	54/9376	0.345875756234322	FANCC	-1.14651663629964
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	4/502	144/9376	0.518813634351483	IL6ST/SMARCAD1/JARID2/CTNNB1	-1.38396289292132
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	4/502	144/9376	0.518813634351483	CCND1/TRA2B/TRA2A/CTNNB1	-1.38396289292132
Organismal Systems	Digestive system	hsa04976	Bile secretion	2/502	90/9376	0.415050907481186	GNAS/ATP1B3	-1.32618090729503
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/502	59/9376	0.316564251468701	NT5E	-1.2524587592331
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	1/502	63/9376	0.296464933915133	GGT5	-1.3325668541134
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	2/502	100/9376	0.373545816733068	CD9/CD34	-1.49791347716336
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	1/502	72/9376	0.259406817175741	ISG15	-1.50033725007962
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	2/502	109/9376	0.342702584158778	FOS/STAT1	-1.64166060640838
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	3/502	143/9376	0.391831276293428	SSB/ACTN4/SNRPB	-1.7430043358646
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	7/502	254/9376	0.514728487624306	GNAS/CALM1/KDR/ITPKB/EDNRB/NFATC1/ATP2B4	-1.86480921227661
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	4/502	183/9376	0.40824679424379	RAN/REXO2/RRP7A/NOP10	-1.92271678986301
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	1/502	86/9376	0.217177800426202	NRG3	-1.73453187939415
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/502	86/9376	0.217177800426202	SCN3A	-1.73453187939415
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	4/502	195/9376	0.383123914598018	ACTB/ACTG1/VWF/HDAC2	-2.07037030840417
NA	NA	hsa04082	Neuroactive ligand signaling	4/502	199/9376	0.375422931390018	GNAS/GNG11/GNAI2/GNG5	-2.11806845389474
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	1/502	99/9376	0.188659503400539	KRT18	-1.93016642621724
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	2/502	154/9376	0.242562218657836	UGP2/DHFR	-2.25409673628962
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	9/502	370/9376	0.454312479810488	CSH1/CALCRL/S1PR1/CSH2/CGA/EDN1/TSPO/EDNRB/ADM	-2.54716276174514
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	6/502	298/9376	0.376052835637316	CSH1/CSH2/IL6ST/TGFBR2/CCL2/TNFRSF10B	-2.60338646573098
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	4/502	449/9376	0.166390118812057	CALM1/ARRB1/PRKG1/ANO2	-4.30537556424665