category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	6/56	168/9376	5.97959183673469	CSH1/EGFR/CSH2/CSF3R/CSHL1/GH2	5.04821016973528
NA	NA	hsa04081	Hormone signaling	6/56	219/9376	4.58708414872798	CSH1/CGA/CSH2/CSHL1/GH2/GNA12	4.16350135831591
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	6/56	233/9376	4.31146535867566	FBN2/ANK3/SDC1/ITGB4/DIAPH2/FBLN1	3.96757835572929
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	3/56	52/9376	9.65934065934066	CYP19A1/CGA/HSD17B1	4.85352264323604
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	5/56	184/9376	4.54968944099379	RASA1/SEMA6A/SEMA3B/SEMA6D/PARD3	3.76934559527515
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	7/56	362/9376	3.23756906077348	CSH1/EGFR/CSH2/CSF3R/CSHL1/GH2/ITGB4	3.36545394885503
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	4/56	122/9376	5.48946135831382	CSH1/CSH2/CSHL1/GH2	3.86884295536586
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	7/56	370/9376	3.16756756756757	CSH1/CGA/KISS1/CSH2/CSHL1/GH2/GABRE	3.29745768000604
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	5/56	204/9376	4.10364145658263	EGFR/EZR/GPC3/ANK3/SDC1	3.47397189402571
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	6/56	298/9376	3.37104506232023	CSH1/CSH2/CSF3R/CSHL1/GDF15/GH2	3.22421909941919
NA	NA	hsa04517	IgSF CAM signaling	6/56	299/9376	3.35977066411849	GRIP1/RASA1/EZR/ANK3/APP/PARD3	3.21444441172748
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	5/56	232/9376	3.60837438423645	EGFR/EZR/GNA12/ITGB4/DIAPH2	3.11829720760298
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	4/56	178/9376	3.76243980738363	ZNRF3/TBL1X/LGR5/SIAH1	2.88421623901876
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	3/56	110/9376	4.56623376623377	EGFR/SLC2A1/EPAS1	2.91629664282201
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	4/56	201/9376	3.3319118692253	SPINT1/GADD45G/PBX1/MLLT1	2.59047151265926
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	5/56	300/9376	2.79047619047619	EGFR/RASA1/GNA12/DUSP9/GADD45G	2.44316967644923
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	2/56	59/9376	5.67554479418886	EGFR/GADD45G	2.79249160207424
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	2/56	65/9376	5.15164835164835	CGA/KISS1	2.60345917452511
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	3/56	148/9376	3.39382239382239	EGFR/GADD45G/NCOA3	2.27531057716836
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2/56	66/9376	5.07359307359307	CYP19A1/HSD17B1	2.57422477848078
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	2/56	70/9376	4.78367346938776	SLC2A1/EPAS1	2.46293438077143
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	2/56	71/9376	4.71629778672032	EGFR/SLC2A1	2.43642578955709
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	3/56	157/9376	3.1992720655141	SLC2A1/GULP1/PBX1	2.15406384935675
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	3/56	157/9376	3.1992720655141	DLG5/PARD3/YAP1	2.15406384935675
Human Diseases	Cancer: specific types	hsa05218	Melanoma	2/56	73/9376	4.58708414872798	EGFR/GADD45G	2.3848615951505
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	2/56	73/9376	4.58708414872798	EGFR/GADD45G	2.3848615951505
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	2/56	75/9376	4.4647619047619	GADD45G/SIAH1	2.3351291253333
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	2/56	75/9376	4.4647619047619	CGA/LRP2	2.3351291253333
Human Diseases	Cancer: specific types	hsa05214	Glioma	2/56	76/9376	4.40601503759398	EGFR/GADD45G	2.31091290811324
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	2/56	77/9376	4.34879406307978	EGFR/GADD45G	2.28711169855468
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/56	15/9376	11.1619047619048	ALPP	3.05303176419939
NA	NA	hsa04519	Cadherin signaling	5/56	404/9376	2.07213578500707	EGFR/GABRE/PCDH11X/RERE/YAP1	1.70752683424027
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	2/56	87/9376	3.84893267651888	EGFR/GADD45G	2.06932653566489
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/56	17/9376	9.84873949579832	PCDH11X	2.83049793493705
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	2/56	89/9376	3.76243980738363	SDC1/ITGB4	2.0296530220569
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	2/56	93/9376	3.60061443932412	EGFR/PARD3	1.95364191371463
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	2/56	93/9376	3.60061443932412	CGA/EGFR	1.95364191371463
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	2/56	99/9376	3.38239538239538	EGFR/NCOA3	1.84713804384486
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	2/56	106/9376	3.15902964959569	EGFR/SPINT1	1.73277976434023
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	2/56	115/9376	2.91180124223602	EGFR/GNA12	1.59894826856901
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/56	28/9376	5.97959183673469	ALPP	2.04543228075362
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/56	29/9376	5.77339901477833	YAP1	1.99554861434722
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	2/56	122/9376	2.74473067915691	SLC2A1/NCOA3	1.50354095031172
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/56	31/9376	5.40092165898618	ACSS1	1.9024205445674
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	2/56	125/9376	2.67885714285714	SPTLC3/GNA12	1.46469130803709
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/56	32/9376	5.23214285714286	ACSS1	1.85883391966254
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	2/56	133/9376	2.51772287862513	EGFR/GADD45G	1.36641782997047
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	1/56	37/9376	4.52509652509652	GADD45G	1.6653034558802
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	2/56	139/9376	2.40904419321686	EGFR/NCOA3	1.2972934888645
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	2/56	142/9376	2.35814889336016	RHOBTB1/SIAH1	1.26406182787963
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/56	41/9376	4.08362369337979	GABRE	1.53379683302989
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	1/56	41/9376	4.08362369337979	EGFR	1.53379683302989
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	2/56	149/9376	2.24736337488015	EGFR/GNA12	1.18967286936968
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	2/56	150/9376	2.23238095238095	EGFR/GADD45G	1.17938493828697
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	1/56	44/9376	3.80519480519481	TUSC3	1.44568506575579
NA	NA	hsa04518	Integrin signaling	2/56	154/9376	2.17439703153989	EGFR/ITGB4	1.13902810920469
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	2/56	155/9376	2.16036866359447	EGFR/PBX1	1.12913150571974
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	1/56	47/9376	3.56231003039514	ACSS1	1.36500661060341
NA	NA	hsa03272	Virion - Hepatitis viruses	1/56	48/9376	3.48809523809524	EGFR	1.33956886710593
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	1/56	50/9376	3.34857142857143	SDC1	1.29066271826976
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	1/56	52/9376	3.21978021978022	LRP2	1.24417712428132
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	2/56	170/9376	1.96974789915966	EZR/PARD3	0.989052894722269
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	2/56	170/9376	1.96974789915966	EGFR/GADD45G	0.989052894722269
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	1/56	54/9376	3.1005291005291	CGA	1.19989357743509
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	1/56	55/9376	3.04415584415584	SPTLC3	1.17851683059486
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	1/56	56/9376	2.98979591836735	TUSC3	1.15762071200252
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	1/56	56/9376	2.98979591836735	LRP2	1.15762071200252
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1/56	59/9376	2.83777239709443	CGA	1.0976183977081
Organismal Systems	Nervous system	hsa04730	Long-term depression	1/56	60/9376	2.79047619047619	GNA12	1.07845277177339
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	3/56	323/9376	1.55506413091552	EGFR/EZR/TP63	0.786900570148432
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	1/56	63/9376	2.65759637188209	GADD45G	1.02323634153994
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	3/56	333/9376	1.50836550836551	EGFR/ITGB4/PARD3	0.732172855210712
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	1/56	65/9376	2.57582417582418	PBX1	0.98818434522737
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	1/56	67/9376	2.49893390191898	ACSS1	0.954421170398804
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	2/56	200/9376	1.67428571428571	EZR/GNA12	0.747143374417762
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	2/56	203/9376	1.64954257565095	EGFR/ITGB4	0.725223119904308
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	1/56	70/9376	2.39183673469388	SLC2A1	0.905998515472553
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	1/56	71/9376	2.35814889336016	CGA	0.890410074689247
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	1/56	71/9376	2.35814889336016	EGFR	0.890410074689247
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	1/56	73/9376	2.29354207436399	MLLT1	0.860007372828411
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	2/56	212/9376	1.57951482479784	EGFR/PARD3	0.661548419234991
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	1/56	76/9376	2.20300751879699	EZR	0.816216479686795
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	1/56	77/9376	2.17439703153989	GADD45G	0.802072966861559
NA	NA	hsa04382	Cornified envelope formation	2/56	217/9376	1.54312047399605	SPTLC3/ITGB4	0.627442175233112
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	1/56	78/9376	2.14652014652015	ISYNA1	0.788144622022734
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	1/56	80/9376	2.09285714285714	EGFR	0.760907783530119
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	2/56	227/9376	1.47514159848962	EGFR/GNA12	0.561721264400823
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	1/56	86/9376	1.9468438538206	EGFR	0.683740694181789
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	1/56	86/9376	1.9468438538206	SLC2A1	0.683740694181789
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	1/56	86/9376	1.9468438538206	ITGB4	0.683740694181789
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	1/56	89/9376	1.88121990369181	EGFR	0.647460493381312
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	1/56	89/9376	1.88121990369181	GABRE	0.647460493381312
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	2/56	238/9376	1.40696278511405	EGFR/RASA1	0.492934589586659
Organismal Systems	Digestive system	hsa04976	Bile secretion	1/56	90/9376	1.86031746031746	SLC2A1	0.635678243486478
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	1/56	90/9376	1.86031746031746	EGFR	0.635678243486478
Human Diseases	Substance dependence	hsa05032	Morphine addiction	1/56	91/9376	1.83987441130298	GABRE	0.624044826805202
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	1/56	93/9376	1.80030721966206	GADD45G	0.601209354427244
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	2/56	250/9376	1.33942857142857	EGFR/PARD3	0.42164782451976
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	1/56	99/9376	1.69119769119769	EGFR	0.535904980618831
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	1/56	99/9376	1.69119769119769	ITGB4	0.535904980618831
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	1/56	100/9376	1.67428571428571	CSF3R	0.52545470383163
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	1/56	105/9376	1.59455782312925	GADD45G	0.474894513764706
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	1/56	105/9376	1.59455782312925	SIAH1	0.474894513764706
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	1/56	105/9376	1.59455782312925	ITGB4	0.474894513764706
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	1/56	107/9376	1.56475300400534	SLC2A1	0.455413282445499
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	1/56	109/9376	1.53604193971166	SLC2A1	0.436329054567971
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	1/56	115/9376	1.45590062111801	APP	0.381295655987541
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	1/56	116/9376	1.44334975369458	ACSS1	0.372427437039893
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	1/56	116/9376	1.44334975369458	EZR	0.372427437039893
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	1/56	116/9376	1.44334975369458	SHANK2	0.372427437039893
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	1/56	130/9376	1.28791208791209	EGFR	0.256227846269565
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	1/56	134/9376	1.24946695095949	GNA12	0.225452020418441
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	1/56	137/9376	1.22210636079249	GADD45G	0.202992733499851
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	1/56	142/9376	1.17907444668008	SDC1	0.166668892861166
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	1/56	144/9376	1.16269841269841	DUSP9	0.152506501898125
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	1/56	149/9376	1.12368168744008	GABRE	0.117961414410983
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	1/56	154/9376	1.08719851576994	ALPP	0.0845723872553242
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	1/56	154/9376	1.08719851576994	EGFR	0.0845723872553242
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	1/56	155/9376	1.08018433179724	COLEC12	0.0780257672737234
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	1/56	156/9376	1.07326007326007	EGFR	0.0715213795470236
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	1/56	157/9376	1.06642402183803	GADD45G	0.0650586102619127
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	1/56	158/9376	1.05967450271248	GADD45G	0.0586368586319287
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	1/56	160/9376	1.04642857142857	SDC1	0.0459140681785382
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	1/56	166/9376	1.00860585197935	GNA12	0.00867141150654953
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	1/56	174/9376	0.962233169129721	TUSC3	-0.0389776587100551
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	1/56	180/9376	0.93015873015873	SRSF5	-0.0733365699920462
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	1/56	193/9376	0.867505551443375	PARD3	-0.144163640171792
NA	NA	hsa04082	Neuroactive ligand signaling	1/56	199/9376	0.841349605168701	GABRE	-0.175343239166298
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	1/56	205/9376	0.816724738675958	GADD45G	-0.205657298550643
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	1/56	205/9376	0.816724738675958	SLC2A1	-0.205657298550643
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	1/56	217/9376	0.771560236998025	EGFR	-0.263905981582897
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	1/56	224/9376	0.747448979591837	SLC2A1	-0.296542419420771
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	1/56	226/9376	0.740834386852086	CGA	-0.305698104330991
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	1/56	227/9376	0.737570799244808	EGFR	-0.310248698351183
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	1/56	238/9376	0.703481392557023	EGFR	-0.359158830760781
Genetic Information Processing	Transcription	hsa03040	Spliceosome	1/56	243/9376	0.689006466784245	SRSF5	-0.380732071643569
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	1/56	253/9376	0.661773009599097	EGFR	-0.422738089048794
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	1/56	254/9376	0.659167604049494	EGFR	-0.426858945735084
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	1/56	388/9376	0.431516936671576	APP	-0.88648942011124
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	1/56	480/9376	0.348809523809524	APP	-1.13527994856424