category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	58/489	268/9376	4.14955895369777	MT-ND3/MT-ND4/MT-CYB/TUBA1B/MT-CO2/MT-ATP6/MT-CO3/MT-ND5/MT-ND2/TUBB/TUBB4B/UBB/MT-CO1/SOD1/HSPA5/GNAS/MT-ND1/TUBA1A/PSMB6/MT-ND6/ATP5F1E/ATP5F1B/CALM1/GNAI2/MT-ND4L/NDUFA6/COX4I1/PSMB3/PARK7/NDUFA12/PSMC2/ATP5MC2/PSMC3/SEM1/TUBB6/COX7C/NDUFA1/UBC/NDUFA4/SDHA/PSMB2/COX7A2L/ATP5F1A/TXN/COX5B/COX7A2/UQCR10/NDUFB5/PSMA4/UBA52/PSMD2/VDAC1/UBE2L6/NDUFB1/PSMB1/PSMD14/PSMB7/RPS27A	12.2706651693763
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	54/489	238/9376	4.35036345826674	ISG15/FOS/VWF/RPL15/RPL19/RPS25/RPS3/RPL14/IL6ST/RPS18/RPL3/RPS9/RPL28/RPS6/OAS1/MX1/RPS7/RPL41/RPS8/RPS13/RPS15/RPL18/RPL36AL/RPL29/RPL8/RPL10A/RPS24/RPL13A/OAS2/RPL36/RPS27L/FAU/RPS4X/RPL4/RPL24/RPL21/RPL11/RPS15A/STAT1/RPL7A/RPS14/RPL23/CCL2/RPS19/RPL23A/EIF2AK2/RPL27/RPS23/UBA52/RPSA/RPL5/RPL7/RPL6/RPS27A	12.28053543563
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	53/489	275/9376	3.69531883249675	MT-ND3/MT-ND4/MT-CYB/TUBA1B/MT-CO2/MT-ATP6/MT-CO3/MT-ND5/CAV1/MT-ND2/TUBB/TUBB4B/HSPA8/MT-CO1/SOD1/HSPA5/MT-ND1/TUBA1A/PSMB6/MT-ND6/ATP5F1E/ATP5F1B/MT-ND4L/NDUFA6/COX4I1/PSMB3/NDUFA12/PSMC2/ATP5MC2/PSMC3/SEM1/TUBB6/COX7C/NDUFA1/CAV2/NDUFA4/SDHA/PSMB2/COX7A2L/NCAM1/ATP5F1A/COX5B/COX7A2/CREB3L2/UQCR10/NDUFB5/PSMA4/PSMD2/VDAC1/NDUFB1/PSMB1/PSMD14/PSMB7	10.6412932905343
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	56/489	308/9376	3.48614984197806	MT-ND3/MT-ND4/MT-CYB/TUBA1B/MT-CO2/MT-ATP6/MT-CO3/MT-ND5/MT-ND2/TUBB/TUBB4B/MT-CO1/SOD1/MT-ND1/TUBA1A/PSMB6/MT-ND6/ATP5F1E/ATP5F1B/RB1CC1/MT-ND4L/NDUFA6/COX4I1/PSMB3/POLR2L/NDUFA12/PSMC2/ATP5MC2/PSMC3/SEM1/TUBB6/COX7C/NDUFA1/NDUFA4/SDHA/PSMB2/COX7A2L/ATP5F1A/AP2M1/COX5B/COX7A2/CREB3L2/TGM2/AP2S1/UQCR10/NDUFB5/PPARG/HDAC2/PSMA4/PSMD2/VDAC1/NDUFB1/PSMB1/PSMD14/PSMB7/ACTR10	10.4066124287283
Genetic Information Processing	Translation	hsa03010	Ribosome	46/489	222/9376	3.97295454964167	RPL15/RPL19/RPS25/RPS3/RPL14/RPS18/RPL3/RPS9/RPL28/RPS6/RACK1/RPS7/RPL41/RPS8/RPS13/RPS15/RPL18/RPL36AL/RPL29/MRPL16/RPL8/RPL10A/RPS24/RPL13A/RPL36/RPS27L/FAU/RPS4X/RPL4/RPL24/RPL21/RPL11/RPS15A/RPL7A/RPS14/RPL23/RPS19/RPL23A/RPL27/RPS23/UBA52/RPSA/RPL5/RPL7/RPL6/RPS27A	10.5153027380687
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	55/489	368/9376	2.86565306303903	MT-ND3/ACTB/MT-ND4/MT-CYB/TUBA1B/MT-CO2/ACTG1/MT-ATP6/MT-CO3/MT-ND5/MT-ND2/TUBB/TUBB4B/MT-CO1/SOD1/HSPA5/MT-ND1/SRSF3/TUBA1A/PSMB6/MT-ND6/ATP5F1E/ATP5F1B/RB1CC1/MT-ND4L/NDUFA6/COX4I1/PSMB3/NDUFA12/PSMC2/ATP5MC2/PSMC3/SEM1/TUBB6/COX7C/NDUFA1/TPR/SRSF7/NDUFA4/SDHA/PSMB2/COX7A2L/ATP5F1A/COX5B/COX7A2/UQCR10/NDUFB5/PSMA4/PSMD2/VDAC1/NDUFB1/PSMB1/PSMD14/PSMB7/ACTR10	8.5645211019006
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	31/489	138/9376	4.30716339171927	MT-ND3/MT-ND4/MT-CYB/MT-CO2/MT-ATP6/MT-CO3/MT-ND5/MT-ND2/MT-CO1/MT-ND1/MT-ND6/ATP5F1E/ATP5F1B/MT-ND4L/NDUFA6/COX4I1/NDUFA12/ATP5MC2/ATP6V1F/COX7C/NDUFA1/NDUFA4/SDHA/COX7A2L/ATP5F1A/COX5B/COX7A2/ATP5MG/UQCR10/NDUFB5/NDUFB1	9.18054986500858
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	55/489	388/9376	2.71793898762465	MT-ND3/GAPDH/MT-ND4/MT-CYB/TUBA1B/MT-CO2/MT-ATP6/MT-CO3/MT-ND5/MT-ND2/TUBB/TUBB4B/MT-CO1/MT-ND1/TUBA1A/PSMB6/MT-ND6/ATP5F1E/ATP5F1B/RB1CC1/CALM1/MT-ND4L/NDUFA6/COX4I1/PSMB3/NDUFA12/PSMC2/ATP5MC2/PSMC3/SEM1/TUBB6/COX7C/ADAM10/NDUFA1/NDUFA4/SDHA/NCSTN/PSMB2/COX7A2L/ATP5F1A/CAPN2/COX5B/COX7A2/EIF2AK2/UQCR10/NDUFB5/PSMA4/PSMD2/VDAC1/NDUFB1/PSMB1/PSMD14/PSMB7/APP/CTNNB1	8.10689493206593
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	38/489	227/9376	3.20971505274632	MT-ND3/MT-ND4/MT-CYB/MT-CO2/MT-ATP6/MT-CO3/MT-ND5/MT-ND2/FOS/MT-CO1/SOD1/MT-ND1/MT-ND6/ATP5F1E/ATP5F1B/PLD1/MT-ND4L/NDUFA6/COX4I1/HMOX1/NDUFA12/ATP5MC2/PRKD3/MGST3/COX7C/NDUFA1/NDUFA4/SDHA/COX7A2L/ATP5F1A/PRKD1/COX5B/COX7A2/UQCR10/NDUFB5/GSTO1/VDAC1/NDUFB1	7.9054185162831
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	60/489	480/9376	2.39672801635992	MT-ND3/MT-ND4/MT-CYB/TUBA1B/MT-CO2/MT-ATP6/MT-CO3/MT-ND5/MT-ND2/TUBB/TUBB4B/UBB/MT-CO1/SOD1/HSPA5/MT-ND1/TUBA1A/PSMB6/MT-ND6/ATP5F1E/ATP5F1B/RB1CC1/CALM1/MT-ND4L/NDUFA6/COX4I1/PSMB3/PARK7/NDUFA12/PSMC2/ATP5MC2/PSMC3/SEM1/TUBB6/COX7C/NDUFA1/UBC/NDUFA4/SDHA/PSMB2/COX7A2L/ATP5F1A/CAPN2/COX5B/COX7A2/UQCR10/NDUFB5/PSMA4/UBA52/PSMD2/VDAC1/UBE2L6/NDUFB1/PSMB1/PSMD14/PSMB7/ACTR10/RPS27A/APP/CTNNB1	7.36881331099259
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	38/489	235/9376	3.10044815733368	MT-ND3/ACTB/MT-ND4/MT-CYB/MT-CO2/ACTG1/MT-ATP6/MT-CO3/MT-ND5/MT-ND2/MT-CO1/GNAS/MT-ND1/MT-ND6/ATP5F1E/ATP5F1B/MT-ND4L/NDUFA6/COX4I1/RPS6/NDUFA12/ATP5MC2/COX7C/NDUFA1/NDUFA4/SDHA/COX7A2L/COA1/ATP5F1A/COX5B/COX7A2/CREB3L2/PRKG1/ATP5MG/UQCR10/NDUFB5/PPARG/NDUFB1	7.64912082768029
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	34/489	205/9376	3.1800488802434	MT-ND3/GAPDH/MT-ND4/MT-CYB/MT-CO2/MT-ATP6/MT-CO3/MT-ND5/MT-ND2/MT-CO1/MT-ND1/MT-ND6/ATP5F1E/ATP5F1B/MT-ND4L/NDUFA6/COX4I1/TGFBR2/NDUFA12/ATP5MC2/COX7C/NDUFA1/NDUFA4/SDHA/COX7A2L/ATP5F1A/TBC1D4/COX5B/COX7A2/PPP1CA/UQCR10/NDUFB5/VDAC1/NDUFB1	7.40282175860385
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	14/489	46/9376	5.83551169200676	PSMB6/PSME1/PSMB3/PSMC2/PSMC3/POMP/SEM1/PSMB2/PSMA4/PSMD2/PSME4/PSMB1/PSMD14/PSMB7	7.71157362631225
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	24/489	142/9376	3.24064633197961	ACTB/ACTG1/CAV1/HSP90AB1/HSP90B1/FOS/CTSL/SDC4/CALM1/EDN1/KDR/MAPK7/PECAM1/HMOX1/MGST3/GSTP1/CAV2/ITGAV/TXN/CCL2/CDH5/GSTO1/SUMO2/CTNNB1	6.31080886329014
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	29/489	203/9376	2.73911773298276	ACTB/ACTG1/FN1/THBS1/CAV1/ITGB1/EMP1/MYL12A/VWF/LAMB2/ITGB4/FLNB/COL6A2/MYL12B/CCND1/KDR/CDC42/COL4A1/COL6A1/ACTN4/DIAPH1/CAV2/ILK/LAMC2/ITGAV/RAP1A/CAPN2/PPP1CA/CTNNB1	5.87602700830366
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	26/489	174/9376	2.86505418047622	HSP90AB1/HSP90B1/HSPA8/HSPA5/HERPUD1/RBX1/CALR/SKP1/OS9/BCAP31/SEC61A1/RPN1/TUSC3/SEC61B/CANX/UBXN4/LMAN2/DNAJC3/DNAJA1/SEC62/OSTC/RRBP1/CAPN2/TRAM1/DDOST/PDIA4	5.8248861337379
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	31/489	233/9376	2.55102381140455	ACTB/ACTG1/MYH9/FN1/VIM/THBS1/ITGB1/TPM4/TPM3/SDC4/ITGB4/SPTAN1/AGRN/COL6A2/SUN2/ENO1/PDLIM1/ATP1B3/COL4A1/SDC3/AMPD1/COL6A1/HSPG2/DIAPH1/FLNC/ITGAV/DAG1/MYH10/LMNA/SYNE3/CAPZA1	5.62360156973178
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	24/489	155/9376	2.96885018800712	HLA-C/ACTB/TUBA1B/ACTG1/THBS1/ITGB1/TUBB/TUBB4B/CTSL/TUBA1A/CALR/MRC1/SEC61A1/SEC61B/HLA-A/CANX/CTSS/LAMP1/ATP6V1F/TUBB6/MSR1/ITGAV/LAMP2/STX7	5.79764991237994
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	32/489	248/9376	2.47404182333927	ACTB/S100A10/GAPDH/TUBA1B/ANXA2/ACTG1/HSP90AB1/HSP90B1/TUBB/FOS/TUBB4B/MYL12A/TUBA1A/MYL12B/AHNAK/RPS3/ARF1/CDC42/SKP1/DYNLL1/ARPC3/TUBB6/ARPC2/ABI1/PODXL/GCC2/ARPC1B/TXN/TNFRSF10B/KPNA4/ACTR10/CTNNB1	5.51836355001855
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	16/489	78/9376	3.93309212941115	ACTB/ACTG1/FN1/CAV1/ITGB1/ARHGAP10/CDC42/ARPC3/CTTN/WASF2/ARPC2/CAV2/ILK/ARPC1B/CTNNA1/CTNNB1	6.10155756025158
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	27/489	200/9376	2.58846625766871	ACTB/GAPDH/TUBA1B/ACTG1/MYH9/ITGB1/TUBB/FOS/TUBB4B/TUBA1A/RPS3/ARF1/CDC42/TMBIM6/ARPC3/CTTN/TUBB6/WASF2/ARPC2/BAIAP2L1/ABI1/ARPC1B/MYH10/TNFRSF10B/MYO1C/NCL/OCLN	5.32633854535718
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	24/489	170/9376	2.70689281847708	ACTB/TUBA1B/ACTG1/MYH9/ITGB1/MYL12A/TUBA1A/DLG2/MYL6/MYL12B/CCND1/CDC42/MSN/PRKCE/ARPC3/CTTN/F11R/ACTN4/ARPC2/PPP2R1A/ARPC1B/RAP1A/MYH10/OCLN	5.26814480969062
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	19/489	116/9376	3.14054015936817	ACTB/ACTG1/ITGB1/CD99/MYL12A/MYL12B/GNAI2/CDC42/PECAM1/MSN/F11R/ACTN4/RAP1A/CTNND1/CD99L2/CDH5/CTNNA1/CTNNB1/OCLN	5.44138379784383
NA	NA	hsa04518	Integrin signaling	21/489	154/9376	2.61461238148355	ACTB/ACTG1/FN1/THBS1/ITGB1/VWF/LAMB2/ITGB4/FLNB/LIMS1/COL6A2/CCND1/KDR/CDC42/COL4A1/COL6A1/ACTN4/ILK/LAMC2/ITGAV/CTNNB1	4.73891105704351
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	15/489	89/9376	3.23154339284483	FN1/THBS1/ITGB1/VWF/LAMB2/SDC4/ITGB4/AGRN/COL6A2/COL4A1/COL6A1/HSPG2/LAMC2/ITGAV/DAG1	4.96163822130919
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	24/489	204/9376	2.25574401539757	ACTB/DDX5/ACTG1/FN1/THBS1/CAV1/ITGB1/CTSL/SDC4/CD63/CCND1/KDR/CDC42/TIMP3/RPS6/HSPG2/MSN/MDM2/CTTN/CAV2/LUM/ITGAV/PPP1CA/CTNNB1	4.25350213808238
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	20/489	157/9376	2.442525366991	MT-CYB/MT-CO2/MT-CO3/FOS/MT-CO1/CDC42/NDUFA6/COX4I1/NDUFA12/COX7C/NDUFA1/NDUFA4/SDHA/COX7A2L/COX5B/COX7A2/UQCR10/NDUFB5/PPARG/NDUFB1	4.27556836848385
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	14/489	93/9376	2.88638212722915	ACTB/ACTG1/MYL12A/MYL12B/CDC42/TGFBR2/ACTN4/WASF2/RAP1A/CTNND1/PDCD10/CDH5/CTNNA1/CTNNB1	4.2883423573487
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	27/489	253/9376	2.04621838550886	ACTB/ACTG1/ITGB1/UBB/MYL12A/MYL12B/RBX1/ARF1/CDC42/SKP1/CAPNS1/MDM2/PRKCE/ARPC3/CTTN/ACTN4/BCL10/DIAPH1/WASF2/ARPC2/UBC/ILK/ARPC1B/CAPN2/UBA52/VDAC1/RPS27A	3.95709292127768
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	13/489	87/9376	2.86505418047622	MT-CYB/MT-CO2/MT-CO3/MT-CO1/TPM4/TPM3/ATP1B3/COX4I1/COX7C/COX7A2L/COX5B/COX7A2/UQCR10	4.0994828630371
NA	NA	hsa03272	Virion - Hepatitis viruses	9/489	48/9376	3.59509202453988	CD9/CD63/CD81/HSPG2/LAMP1/TGOLN2/PDCD6IP/LAMP2/OCLN	4.2280643704279
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	7/489	31/9376	4.32957319084372	SRP14/HSPA5/SEC61A1/SEC61B/SEC62/SPCS2/SPCS1	4.35554231897703
NA	NA	hsa04517	IgSF CAM signaling	29/489	299/9376	1.85966856118897	ACTB/TUBA1B/ACTG1/MYH9/ITGB1/TUBB/TUBB4B/MYL12A/SPTAN1/PMP22/ROBO4/TUBA1A/MYL6/MYL12B/KDR/CDC42/MSN/DYNLL1/ARPC3/TUBB6/F11R/ACTN4/ARPC2/NCAM1/ARPC1B/RAP1A/MYH10/APP/CTNNB1	3.54370816004609
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	12/489	82/9376	2.80592548256771	HLA-C/HSP90AB1/HSPA8/HSPA5/CTSL/PSME1/CALR/HLA-A/CANX/CTSS/B2M/KLRD1	3.85272397927183
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	31/489	333/9376	1.78495059476655	HLA-C/FN1/THBS1/ITGB1/ISG15/VWF/LAMB2/ITGB4/GNAS/COL6A2/DLG2/PKM/CCND1/CDC42/BCAP31/COL4A1/HLA-A/COL6A1/MX1/MDM2/ATP6V1F/JAG1/LAMC2/ITGAV/PPP2R1A/STAT1/RB1/CREB3L2/EIF2AK2/HDAC2/CTNNB1	3.42113846479595
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	25/489	250/9376	1.91738241308793	HLA-C/CAV1/HSPA8/EHD2/SH3GL2/PLD1/ARF1/ARRB1/CDC42/TGFBR2/HLA-A/MDM2/ARPC3/ARPC2/VPS29/CAV2/ARFGEF1/ARPC1B/ARF4/AP2M1/WWP1/PDCD6IP/EHD1/AP2S1/CAPZA1	3.44859869816166
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	5/489	17/9376	5.63936003849393	MYH9/LAMP1/DAG1/MYH10/LAMP2	4.49086802096552
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	23/489	232/9376	1.90085325435442	ACTB/ACTG1/MYH9/FN1/ITGB1/MYL12A/GSN/ITGB4/CFL1/MYL12B/CDC42/MSN/ARPC3/SSH1/ACTN4/DIAPH1/WASF2/ARPC2/ITGAV/ARPC1B/PPP1CA/MYH10/ABI2	3.25906042938952
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	20/489	196/9376	1.95651266641626	HLA-C/FOS/UBB/ZFP36/RCAN1/CCND1/CALM1/GNG11/IL6ST/HLA-A/NFATC1/ANGPT2/UBC/STAT1/RB1/EIF2AK2/GNG5/UBA52/RPS27A/CTNNB1	3.17438719215031
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	8/489	51/9376	3.00765868719676	ACTB/ACTG1/GNAS/ARF1/SEC61A1/SEC61B/ATP6V1F/PDIA4	3.37219769988427
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	16/489	149/9376	2.05893413485953	MT-ND3/MT-ND4/MT-ND5/MT-ND2/MT-ND1/MT-ND6/GNAI2/MT-ND4L/NDUFA6/GNG11/NDUFA12/NDUFA1/NDUFA4/GNG5/NDUFB5/NDUFB1	3.0562881645944
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	20/489	205/9376	1.87061698837847	HLA-C/VIM/ISG15/CCND1/CALR/HLA-A/OAS1/PSMC2/PSMC3/MDM2/SEM1/B2M/OAS2/GADD45B/STAT1/RB1/EIF2AK2/HDAC2/PSMD2/PSMD14	2.95636599866454
Cellular Processes	Cell motility	hsa04814	Motor proteins	19/489	194/9376	1.87784875508612	ACTB/TUBA1B/ACTG1/MYH9/TUBB/TUBB4B/TPM4/MYL12A/TPM3/TUBA1A/MYL6/MYL12B/DYNLL1/TUBB6/KIF13B/MYH10/MYO1C/ACTR10/CAPZA1	2.89810686748392
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	12/489	101/9376	2.27807811455992	FN1/SERPINE1/CCND1/EDN1/CDC42/COL4A1/TGFBR2/PRKCE/NFATC1/DIAPH1/STAT1/CCL2	3.02916969695588
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	30/489	362/9376	1.58899095007287	CSH1/FN1/THBS1/ITGB1/HSP90AB1/HSP90B1/VWF/LAMB2/ITGB4/COL6A2/CSH2/CCND1/KDR/COL4A1/GNG11/YWHAZ/COL6A1/RPS6/MDM2/EFNA5/ANGPT2/LAMC2/ITGAV/PPP2R1A/YWHAB/CREB3L2/DDIT4/GNG5/YWHAG/CDC37	2.68081353749458
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	12/489	108/9376	2.13042490343104	EEF1A1/RAN/MAGOH/KPNB1/SRRM1/UPF3A/SAP18/PNN/TPR/UBE2I/SUMO2/KPNA4	2.77155217945894
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	6/489	37/9376	3.10926877798043	TPM3/CCND1/TPR/GADD45B/PPARG/CTNNB1	3.01540101135719
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	11/489	98/9376	2.15216393305789	GSN/CFL1/PLD1/MARCKS/CDC42/PRKCE/PLPP1/ARPC3/WASF2/ARPC2/ARPC1B	2.68944463018483
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	15/489	156/9376	1.84363693566148	CCND1/CD81/YWHAZ/OAS1/MX1/OAS2/PPP2R1A/YWHAB/STAT1/RB1/EIF2AK2/IFIT1/YWHAG/CTNNB1/OCLN	2.4923836972538
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	15/489	157/9376	1.83189402524325	HLA-C/SERPINE1/CCND1/CALM1/TGFBR2/HLA-A/ZFP36L1/TRPM7/MDM2/NFATC1/GADD45B/RB1/CAPN2/PPP1CA/VDAC1	2.46568958969505
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	15/489	160/9376	1.79754601226994	HLA-C/ITGB1/CD34/CD99/SDC4/PECAM1/HLA-A/SDC3/NRXN3/F11R/ITGAV/NCAM1/CD99L2/CDH5/OCLN	2.38675028924881
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	12/489	122/9376	1.88594991451272	ACTB/ACTG1/RCAN1/CCND1/ATP1B3/MDM2/ITGAV/STAT1/TBC1D4/PFKL/HDAC2/CTNNB1	2.31039808545089
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	13/489	137/9376	1.81941396862359	ACTB/TUBA1B/ACTG1/FOS/CTSL/SPTAN1/TUBA1A/CTSS/GADD45B/CAPN2/LMNA/CTSW/TNFRSF10B	2.26628038981198
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	4/489	23/9376	3.33457810971815	PRCP/LNPEP/CTSA/ATP6AP2	2.62941621947136
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	10/489	99/9376	1.93674991221003	ACTB/ACTG1/ITGB1/TPM4/TPM3/ITGB4/EDN1/ITGAV/DAG1/LMNA	2.19785965892923
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	9/489	86/9376	2.00656299044086	ACTB/ACTG1/ITGB1/ITGB4/ITGAV/DAG1/CTNNA1/LMNA/CTNNB1	2.19960553781976
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	14/489	158/9376	1.69894644197665	CCND1/RBX1/SKP1/YWHAZ/MDM2/BUB3/GADD45B/PPP2R1A/YWHAB/RB1/RAD21/HDAC2/CDC25B/YWHAG	2.07833986365943
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	20/489	250/9376	1.53390593047035	PSAP/HYAL2/CTSL/CD63/OSBPL3/LAMTOR5/CTSS/LAMP1/OSBPL5/ATP6V1F/VPS29/LAPTM5/CTSA/AP2M1/CD164/AP2S1/LAMP2/CTSW/STX17/LAMTOR2	2.00704446749007
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	13/489	144/9376	1.73097023403772	PSMB6/RB1CC1/PSMB3/PSMC2/PSMC3/SEM1/PSMB2/PSMA4/PSMD2/VDAC1/PSMB1/PSMD14/PSMB7	2.0734593150638
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	17/489	205/9376	1.5900244401217	HLA-C/GSN/PKM/CCND1/CDC42/IL6ST/YWHAZ/HLA-A/MDM2/ACTN4/YWHAB/RB1/CREB3L2/EIF2AK2/HNRNPK/HDAC2/YWHAG	2.00355405010612
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	8/489	75/9376	2.0452079072938	HSP90B1/HSPA5/GNAS/CGA/ATP1B3/CANX/CREB3L2/PDIA4	2.13172399551704
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	9/489	89/9376	1.9389260357069	TUBA1B/TUBB/TUBB4B/GNAS/TUBA1A/GNAI2/MAPK7/TUBB6/PRKG1	2.08761851581418
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	18/489	224/9376	1.5407537248028	HLA-C/FOS/ZFP36/CCND1/RAN/CALR/FDPS/TGFBR2/HLA-A/CANX/TSPO/B2M/NFATC1/BUB3/CRTC3/RB1/CREB3L2/VDAC1	1.92144519081235
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	10/489	105/9376	1.82607848865518	ACTB/ACTG1/ITGB1/TPM4/TPM3/ITGB4/GNAS/ITGAV/DAG1/LMNA	1.99671072103289
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	12/489	134/9376	1.71705887739218	MYH9/CALCRL/GNAS/MYL6/CALM1/EDN1/CALD1/PRKCE/ADM/PPP1CA/PRKG1/MYH10	1.96104117140531
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	15/489	180/9376	1.59781867757328	HLA-C/SRSF3/CALR/HLA-A/OAS1/BST2/SRSF5/B2M/OAS2/SRSF7/SRSF6/STAT1/PPP1CA/CCL2/EIF2AK2	1.89962872659042
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	17/489	212/9376	1.53752363313655	ACTB/ACTG1/THBS1/ITGB1/GNAS/RASGRP3/CALM1/GNAI2/KDR/CDC42/PRKD3/EFNA5/ANGPT2/PRKD1/RAP1A/CTNND1/CTNNB1	1.85688681028492
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	9/489	93/9376	1.85553136750445	FN1/ITGB1/LAMB2/CCND1/COL4A1/LAMC2/ITGAV/GADD45B/RB1	1.94489300357124
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	12/489	138/9376	1.66728905485907	ACTB/ACTG1/FN1/ITGB1/FOS/CDC42/ARPC3/NFATC1/WASF2/ARPC2/ARPC1B/CCL2	1.85236703388986
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	13/489	154/9376	1.61856956948981	ACTB/ACTG1/FOS/GNAS/MYL6/RCAN1/CCND1/CALM1/GNAI2/MAPK7/EEF2/NFATC1/PPP1CA	1.81551077275434
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	14/489	170/9376	1.5790208107783	ACTB/ACTG1/CCND1/TGFBR2/TXNRD2/HMOX1/MGST3/GSTP1/GADD45B/TXNRD1/RB1/PBRM1/GSTO1/CTNNB1	1.78708671451681
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	5/489	41/9376	2.33827123547309	THBS1/DAPK1/CCND1/MDM2/RB1	2.01437994191429
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	10/489	110/9376	1.74307492098903	GAPDH/SERPINE1/ENO1/RBX1/EDN1/RPS6/HMOX1/ANGPT2/PGK1/PFKL	1.83884564819473
Organismal Systems	Immune system	hsa04611	Platelet activation	11/489	126/9376	1.67390528126724	ACTB/ACTG1/ITGB1/MYL12A/VWF/GNAS/MYL12B/GNAI2/RAP1A/PPP1CA/PRKG1	1.78638779853013
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	13/489	157/9376	1.58764148854415	ACTB/ACTG1/SERPINE1/DLG2/CCND1/YWHAZ/TGFBR2/PPP2R1A/YWHAB/PPP1CA/CTNNA1/YWHAG/CTNNB1	1.74173807817953
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	7/489	69/9376	1.94517056400225	FOS/GNAS/CALM1/FOSB/CREB3L2/PPP1CA/HDAC2	1.84838465226626
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	7/489	70/9376	1.91738241308793	HLA-C/ACTB/ACTG1/CAV1/CCND1/HLA-A/DAG1	1.80709250109114
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	11/489	130/9376	1.6224005033821	FOS/GNAS/EDN1/GNAI2/ARRB1/COL4A1/GNG11/TGFBR2/EDNRB/CREB3L2/GNG5	1.67620504908427
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	5/489	44/9376	2.17884365123629	MAN2A1/RPN1/TUSC3/OSTC/DDOST	1.83847470856112
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	17/489	227/9376	1.43592515517599	HLA-C/GNAS/CCND1/CALM1/GNAI2/CALR/GNG11/HLA-A/MDM2/B2M/NFATC1/ITGAV/RB1/CREB3L2/CCL2/GNG5/CTNNB1	1.55955438198187
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	7/489	73/9376	1.83858587556377	PPIA/RAN/MAP1B/MX1/BST2/PDCD6IP/NELFE	1.68717425779499
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	6/489	59/9376	1.94988042008943	GGT5/MGST3/GSTP1/LAP3/GSTO1/PRDX6	1.71679868273503
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	4/489	33/9376	2.32409989465204	BET1/VAMP5/STX7/STX17	1.78729822559036
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	7/489	75/9376	1.78955691888207	GAPDH/GLUL/PKM/ENO1/PGAM1/PGK1/PFKL	1.61031830898147
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	7/489	75/9376	1.78955691888207	THBS1/SESN3/SERPINE1/CCND1/MDM2/GADD45B/TNFRSF10B	1.61031830898147
Organismal Systems	Digestive system	hsa04978	Mineral absorption	6/489	61/9376	1.88594991451272	MT2A/ATP1B3/HMOX1/TRPM7/FTL/ATP2B4	1.62834016772223
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	13/489	169/9376	1.47490954852918	UBB/DAPK1/CTSL/RB1CC1/LAMP1/UBC/TAX1BP1/DDIT4/LAMP2/STX7/UBA52/STX17/RPS27A	1.46136149481021
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	7/489	77/9376	1.74307492098903	CCND1/PLD1/CDC42/TGFBR2/GADD45B/STAT1/RB1	1.53575635241484
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	7/489	77/9376	1.74307492098903	CCND1/TGFBR2/BCR/MDM2/GADD45B/RB1/HDAC2	1.53575635241484
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	3/489	23/9376	2.50093358228861	FDPS/PCYOX1/ACAT1	1.69048921053037
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	5/489	50/9376	1.91738241308793	THBS1/CD81/GYPC/PECAM1/CCL2	1.52563338754864
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	11/489	142/9376	1.48529623549065	UBB/RBX1/SKP1/MDM2/UBC/UBE2I/MID1/WWP1/UBA52/UBE2L6/RPS27A	1.3668430133505
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	6/489	67/9376	1.71705887739218	GAPDH/PKM/ENO1/PGAM1/PGK1/PFKL	1.38166635034628
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	8/489	98/9376	1.56521013313301	GNAS/CALM1/ATP1B3/PRKD3/PRKCE/PRKD1/CREB3L2/ATP2B4	1.3193446816602
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	5/489	53/9376	1.80885133310183	GNAS/ATP1B3/AP2M1/ATP2B4/AP2S1	1.38513236137407
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	9/489	116/9376	1.4876242860165	GAPDH/PKM/ENO1/SDHA/PGAM1/PGK1/ESD/PFKL/ACAT1	1.23957071197793
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	10/489	133/9376	1.44164091209619	FOS/GNAS/CALM1/GNAI2/ARRB1/GNG11/PPP2R1A/CREB3L2/PPP1CA/GNG5	1.2032368382012
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	5/489	56/9376	1.71194858311423	MAN2A1/RPN1/TUSC3/OSTC/DDOST	1.25342157258069
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	8/489	103/9376	1.48922905870908	MAGOH/SRRM1/UPF3A/SAP18/PNN/PPP2R1A/PPP1CA/CSTF3	1.17107094240809
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	8/489	103/9376	1.48922905870908	FOS/SERPINE1/GNAS/GNAI2/CALR/TGFBR2/PPP2R1A/CCL2	1.17107094240809
Human Diseases	Infectious disease: viral	hsa05162	Measles	10/489	136/9376	1.40984000962348	FOS/HSPA8/CCND1/OAS1/MX1/RACK1/MSN/OAS2/STAT1/EIF2AK2	1.12930252536613
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	8/489	106/9376	1.44708106648146	HSP90AB1/HSP90B1/CCND1/MDM2/GSTP1/RB1/CREB3L2/CTNNB1	1.08582996256976
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	10/489	139/9376	1.37941180797693	HSP90AB1/HSP90B1/FOS/HSPA8/KRT18/GNAS/CALM1/GNAI2/FKBP5/CREB3L2	1.05709799422151
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	12/489	173/9376	1.32997624029221	ACTB/ACTG1/FDPS/DNAJC3/OAS1/MX1/OAS2/STAT1/CCL2/EIF2AK2/TNFRSF10B/VDAC1	1.02755124116194
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	5/489	59/9376	1.62490035007452	CCND1/ILK/GADD45B/CTNNA1/CTNNB1	1.12943490060317
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	4/489	44/9376	1.74307492098903	GNAS/DYNLL1/ARHGDIA/CREB3L2	1.15886822427359
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	11/489	157/9376	1.34338895184505	THBS1/S1PR1/CALR/BSG/PECAM1/NFATC1/ADAM10/ITGAV/ANO6/ADAM9/PPARG	1.01778656666401
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	6/489	76/9376	1.513722957701	ACTB/ACTG1/GNAS/CALM1/ATP1B3/GNAI2	1.0547675830424
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	8/489	110/9376	1.39445993679123	THBS1/RBX1/LTBP1/SKP1/TGFBR2/THSD4/PPP2R1A/HDAC2	0.976147784923587
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	7/489	94/9376	1.42783796719314	HSP90AB1/HSP90B1/FOS/MAPK7/FOSB/USP25/CCL2	0.977878605523754
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/489	17/9376	2.25574401539757	TXNRD2/TXNRD1	1.21555141107317
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	14/489	214/9376	1.25436232631921	HLA-C/FOS/CFL1/RBX1/CALM1/GNAI2/CALR/SKP1/GNG11/HLA-A/BST2/B2M/NFATC1/GNG5	0.882931495193489
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	7/489	97/9376	1.38367803006346	FOS/GNAS/CALM1/GNAI2/GNG11/PRKG1/GNG5	0.890973298819506
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	14/489	217/9376	1.23702091166964	HSP90AB1/HSP90B1/FOS/GNAS/CCND1/GNAI2/ARRB1/KPNB1/MGST3/JAG1/RB1/CREB3L2/GSTO1/KPNA4	0.828619175557608
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	11/489	166/9376	1.27055461108237	CALM1/ATP1B3/GNAI2/EDNRB/PRKCE/NFATC1/CREB3L2/ATP2B4/PPP1CA/PRKG1/VDAC1	0.824976631228184
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	4/489	49/9376	1.56521013313301	GALNT18/GALNT1/COLGALT1/FUT11	0.930463772570873
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	4/489	49/9376	1.56521013313301	GNAS/GNAI2/FOSB/CREB3L2	0.930463772570873
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	3/489	34/9376	1.69180801154818	RBX1/SKP1/NR1D1	0.947911062787785
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	7/489	101/9376	1.32887890015995	GNAS/CALM1/EDN1/GNAI2/EDNRB/CREB3L2/CTNNB1	0.779475046934625
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/489	20/9376	1.91738241308793	UGP2/CYB5R3	0.963347066101879
NA	NA	hsa04519	Cadherin signaling	24/489	404/9376	1.13903905727996	CDH13/ACTB/ACTG1/VIM/KRT18/KDR/CDC42/YWHAZ/ARPC3/ACTN4/ADAM10/ARPC2/NCSTN/ARPC1B/YWHAB/PPP1CA/CTNND1/CDH5/CTNNA1/PCDH12/ABI2/MYO1C/YWHAG/CTNNB1	0.670108832482528
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	10/489	154/9376	1.24505351499217	TPM4/TPM3/GNAS/CALM1/ATP1B3/GNAI2/PPP2R1A/CREB3L2/ATP2B4/PPP1CA	0.719235666145908
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	4/489	52/9376	1.47490954852918	GNAS/CGA/HSD17B2/HSD17B7	0.805515531507479
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	3/489	36/9376	1.59781867757328	GALNT18/GALNT1/ST3GAL2	0.842965439490222
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	7/489	103/9376	1.30307542637044	PRCP/COL18A1/COL8A1/COL6A2/ATP1B3/COL4A1/COL6A1	0.725473720054362
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	7/489	103/9376	1.30307542637044	FN1/PRDX1/LAMB2/GNAS/COL4A1/ACTN4/LAMC2	0.725473720054362
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	14/489	226/9376	1.18775901695713	FOS/GNAS/CGA/PLD1/CALM1/EDN1/ATP1B3/GNAI2/NFATC1/RAP1A/CREB3L2/ATP2B4/PPP1CA/PDE4B	0.670203903510493
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	9/489	138/9376	1.25046679114431	RBX1/CALM1/SKP1/YWHAZ/PPP2R1A/YWHAB/PPP1CA/CPEB4/YWHAG	0.69528553423954
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/489	21/9376	1.82607848865518	CSGALNACT1/CHSY3	0.888938144529925
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	3/489	37/9376	1.55463438899022	GLUL/GLS/RIMKLB	0.792902789323937
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	8/489	122/9376	1.25729994300848	CSH1/FOS/GNAS/CSH2/GNAI2/STAT1/SOCS2/CREB3L2	0.670991989474235
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	9/489	140/9376	1.23260297984224	SERPINE1/CCND1/CALM1/GNAI2/GNG11/RPS6/PRKCE/JAG1/GNG5	0.650428866784131
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	5/489	71/9376	1.3502693049915	FOS/CGA/CCND1/STAT1/SOCS2	0.694921172811384
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	6/489	91/9376	1.26420818445358	FOS/RASGRP3/CD81/BCL10/NFATC1/CARD11	0.594071183372806
Human Diseases	Substance dependence	hsa05032	Morphine addiction	6/489	91/9376	1.26420818445358	GNAS/GNAI2/ARRB1/GNG11/GNG5/PDE4B	0.594071183372806
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/489	23/9376	1.66728905485907	GLUL/GLS	0.751562201589388
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/489	23/9376	1.66728905485907	ATP1B3/GLS	0.751562201589388
NA	NA	hsa04382	Cornified envelope formation	13/489	217/9376	1.1486622751218	S100A10/S100A6/KRT18/ITGB4/S100A4/COL4A1/S100A11/ELOVL1/LAMC2/PPP2R1A/SPTLC2/S100A13/OCLN	0.519719593432519
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	4/489	57/9376	1.34553151795645	HSD17B12/ELOVL1/CBR4/ACAT1	0.613766128602503
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	6/489	93/9376	1.23702091166964	GNAS/CGA/PLD1/CALM1/MAPK7/CDC42	0.538823391304762
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	5/489	76/9376	1.26143579808417	FABP5/UBC/ILK/DBI/PPARG	0.536775709032053
Human Diseases	Cancer: specific types	hsa05214	Glioma	5/489	76/9376	1.26143579808417	CCND1/CALM1/MDM2/GADD45B/RB1	0.536775709032053
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	4/489	59/9376	1.29992028005962	GNAS/CGA/GNAI2/PRKG1	0.542071118471307
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	3/489	42/9376	1.36955886649138	HMOX1/PCBP1/FTL	0.563036890459498
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	10/489	168/9376	1.14129905540948	HSP90AB1/PPIA/GLUL/TRPM7/FTL/STAT1/CAPN2/EIF2AK2/TNFRSF10B/VDAC1	0.43348464840501
Organismal Systems	Nervous system	hsa04730	Long-term depression	4/489	60/9376	1.27825494205862	GNAS/GNAI2/PPP2R1A/PRKG1	0.507184823275545
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	5/489	78/9376	1.22909129044098	ITGB1/FOS/CFL1/CALM1/GNAI2	0.476566583491055
Genetic Information Processing	Transcription	hsa03040	Spliceosome	14/489	243/9376	1.10466476474202	DDX5/HSPA8/SRSF3/SNRPA/MAGOH/SRSF5/TRA2B/PCBP1/SRSF7/SRSF6/SNRPF/SNRPB/SNRPG/HNRNPK	0.387756768381018
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	7/489	115/9376	1.16710233840135	FOS/GNAS/PLD1/GNAI2/ARRB1/CREB3L2/PDE4B	0.422926582609339
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	7/489	116/9376	1.15704111134617	GNAS/GLUL/PLD1/GNAI2/GNG11/GLS/GNG5	0.399208094804751
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	3/489	44/9376	1.30730619074177	HLA-C/HLA-A/ICA1	0.479261739986049
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	7/489	117/9376	1.14715187107825	ACTB/ACTG1/MORF4L2/MORF4L1/PBRM1/HDAC2/YY1	0.375698235314798
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	6/489	99/9376	1.16204994732602	FOS/GNAS/CCND1/MDM2/JAG1/RB1	0.380211449520382
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	6/489	99/9376	1.16204994732602	FOS/PLD1/DGKH/PLPP1/WASF2/SLC44A2	0.380211449520382
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/489	10/9376	1.91738241308793	SQOR	0.680825495924751
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	2/489	27/9376	1.42028326895403	HSD17B12/ELOVL1	0.512984072932115
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	3/489	45/9376	1.27825494205862	HLA-C/HLA-A/KLRD1	0.43888175446197
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	2/489	28/9376	1.36955886649138	HSD17B12/ELOVL1	0.459373319697617
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	5/489	83/9376	1.15504964643851	AUTS2/SKP1/HDAC2/YY1/JARID2	0.332808443142487
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	3/489	47/9376	1.22386111473698	PKM/PRKCE/SOCS2	0.360888067067172
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	12/489	216/9376	1.06521245171552	HSP90AB1/HSP90B1/FOS/HSPA8/HSPA5/CALM1/CDC42/NFATC1/RAP1A/CCL2/PPARG/TNFRSF10B	0.227442774530968
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	4/489	66/9376	1.16204994732602	HSD17B2/HSD17B7/HSD17B11/HSD17B12	0.30989066871409
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	6/489	105/9376	1.09564709319311	UBB/UBC/TAX1BP1/USP15/UBA52/RPS27A	0.231188172839621
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/489	12/9376	1.59781867757328	NCAM1	0.486062232973026
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	5/489	87/9376	1.10194391556778	FOS/CCND1/TGFBR2/GADD45B/CTNNB1	0.224077852126686
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	7/489	125/9376	1.07373415132924	S1PR1/PLD1/GNAI2/PRKCE/ORMDL1/PPP2R1A/SPTLC2	0.194666773010855
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	9/489	163/9376	1.05867740599947	FOS/YWHAZ/TGFBR2/HSPG2/NFATC1/YWHAB/STAT1/RB1/CREB3L2	0.177266492133892
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	2/489	31/9376	1.23702091166964	GLUL/ACAT1	0.310056139957689
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	6/489	107/9376	1.07516770827361	GNAS/PKM/CALM1/PGAM1/CREB3L2/PFKL	0.183429522299642
Organismal Systems	Endocrine system	hsa04924	Renin secretion	4/489	69/9376	1.11152603657272	GNAS/CALM1/EDN1/GNAI2	0.218101390564044
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	5/489	89/9376	1.07718113094828	GLUL/GNAI2/GNG11/GLS/GNG5	0.171605378817508
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/489	13/9376	1.47490954852918	XRCC5	0.401918080620196
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	2/489	32/9376	1.19836400817996	UGP2/PFKL	0.26365373441449
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	6/489	109/9376	1.05543986041538	HSP90AB1/FOS/IL6ST/TGFBR2/NFATC1/STAT1	0.136561498377433
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	4/489	71/9376	1.0802154439932	CDC42/ATP6V1F/F11R/ADAM10	0.159144434362281
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	4/489	71/9376	1.0802154439932	PKM/GLS/PGAM1/PFKL	0.159144434362281
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	3/489	52/9376	1.10618216139689	TSPO/OSBPL5/VDAC1	0.180100358982295
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/489	14/9376	1.36955886649138	ST3GAL2	0.324583025064305
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	6/489	112/9376	1.02716914986854	ITGB1/HSPA8/LAMB2/GNAI2/LAMC2/STAT1	0.0678497521005035
Human Diseases	Cancer: specific types	hsa05218	Melanoma	4/489	73/9376	1.05062050032216	CCND1/MDM2/GADD45B/RB1	0.101844793179741
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	5/489	93/9376	1.0308507597247	FOS/MAF/NFATC1/JAG1/STAT1	0.0701335205492701
Organismal Systems	Digestive system	hsa04970	Salivary secretion	5/489	93/9376	1.0308507597247	GNAS/CALM1/ATP1B3/ATP2B4/PRKG1	0.0701335205492701
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	3/489	54/9376	1.06521245171552	HLA-C/CGA/HLA-A	0.112728917456474
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/489	15/9376	1.27825494205862	ST3GAL2	0.252982145316998
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	3/489	55/9376	1.04584495259342	PSAP/PLPP1/SPTLC2	0.0799841799354948
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	4/489	75/9376	1.0226039536469	MDM2/MGST3/GSTP1/GSTO1	0.0461012493747848
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	3/489	56/9376	1.02716914986854	EEF1A1/HSPA8/ARF1	0.0478326656750122
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/489	16/9376	1.19836400817996	ST3GAL2	0.186271932307445
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	4/489	78/9376	0.983273032352787	ENO1/BTG2/PFKL/NUDT16	-0.0347962325780836
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	4/489	78/9376	0.983273032352787	ITGB1/EEF1A1/FOS/STAT1	-0.0347962325780836
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/489	38/9376	1.00914863846733	NNMT/NT5E	0.013255124365295
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/489	17/9376	1.12787200769878	GGT5	0.123779207775724
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/489	17/9376	1.12787200769878	GLUL	0.123779207775724
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	6/489	120/9376	0.958691206543967	CALM1/MAPK7/CDC42/ARHGDIA/RAP1A/SH2B3	-0.106827714738278
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	15/489	300/9376	0.958691206543967	FOS/HSPA8/DUSP6/RASGRP3/ARRB1/KDR/MAPK7/CDC42/TGFBR2/EFNA5/NFATC1/ANGPT2/GADD45B/RAP1A/CDC25B	-0.170576175074527
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	10/489	201/9376	0.953921598551211	DDX5/DUSP6/TGFBR2/TSPAN7/MDM2/MAF/GADD45B/ZBTB16/PPARG/HDAC2	-0.154901232766833
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/489	39/9376	0.983273032352787	HLA-C/HLA-A	-0.0245532122838329
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	7/489	142/9376	0.945188513494052	FOS/TGFBR2/FOSB/NFATC1/STAT1/PPARG/FOSL2	-0.154377248169387
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	6/489	122/9376	0.942974957256361	CCND1/EEF2/PPP2R1A/CREB3L2/PFKL/PPARG	-0.148711058514094
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	6/489	122/9376	0.942974957256361	FOS/CDC42/BCL10/NFATC1/PPP2R1A/CARD11	-0.148711058514094
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/489	18/9376	1.06521245171552	CBR4	0.0649587617832409
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/489	18/9376	1.06521245171552	PRDX1	0.0649587617832409
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	16/489	323/9376	0.949786953851608	VIM/THBS1/CCND1/MARCKS/MAPK7/TIMP3/HMOX1/MDM2/PRKCE/EFNA5/GLS/UBE2I/DDIT4/HNRNPK/HDAC2/CDC25B	-0.215419020618121
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	9/489	184/9376	0.937850093358229	ITGB1/MYL12A/CFL1/MYL12B/GNAI2/CDC42/SSH1/EFNA5/ILK	-0.199713242090278
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	3/489	62/9376	0.927765683752226	HSPA8/SOD1/HDAC2	-0.133854745246674
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	3/489	62/9376	0.927765683752226	JAG1/NCSTN/HDAC2	-0.133854745246674
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	5/489	104/9376	0.921818467830738	PLD1/DGKH/PLPP1/PNPLA6/GPAT3	-0.188060078541737
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	2/489	41/9376	0.935308494189236	SEM1/SSBP1	-0.0973743350848955
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/489	19/9376	1.00914863846733	HYAL2	0.00936326745891829
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	5/489	105/9376	0.913039244327588	CALM1/MDM2/BCL10/NFATC1/STAT1	-0.210192464208696
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	9/489	187/9376	0.92280436993537	TXNIP/HSP90AB1/OAS1/TRPM7/OAS2/TXN/STAT1/CCL2/VDAC1	-0.250116228547344
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	4/489	85/9376	0.902297606159028	AMPD1/NT5E/GUK1/NUDT16	-0.212249128232416
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/489	20/9376	0.958691206543967	HSD17B7	-0.0433785348534505
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	4/489	86/9376	0.891805773529272	GNAS/ATP1B3/PCLO/CREB3L2	-0.236432912758797
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/489	43/9376	0.891805773529272	PLPP1/ACAT1	-0.166797738812063
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	3/489	65/9376	0.884945729117508	DGKH/PLPP1/GPAT3	-0.218335189411431
Human Diseases	Substance dependence	hsa05034	Alcoholism	9/489	191/9376	0.903478623968137	GNAS/CALM1/GNAI2/GNG11/FOSB/CREB3L2/PPP1CA/GNG5/HDAC2	-0.316128088744159
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	3/489	66/9376	0.871537460494516	MAF/NFATC1/STAT1	-0.245660939290366
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	4/489	88/9376	0.871537460494516	TFPI/CLU/VWF/SERPINE1	-0.284000571168055
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	3/489	67/9376	0.85852943869609	CALM1/RAP1A/PPP1CA	-0.272592837605032
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/489	45/9376	0.852169961372415	ABCA4/ABCA6	-0.233167131678064
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	3/489	68/9376	0.845904005774089	DUSP6/CCND1/ZBTB16	-0.299143861856837
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	4/489	90/9376	0.852169961372415	SESN3/RB1CC1/CREB3L2/PPARG	-0.330546134767051
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/489	46/9376	0.833644527429537	HMOX1/FTL	-0.265300252915882
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	7/489	155/9376	0.865914638168745	GNAS/CCND1/GNAI2/RAP1A/RB1/CREB3L2/CTNNB1	-0.39483958251759
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/489	23/9376	0.833644527429537	SSBP1	-0.187364807351598
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	2/489	47/9376	0.815907409824653	PKM/ACAT1	-0.296776950779632
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	3/489	70/9376	0.821735319894829	MGST3/GSTP1/GSTO1	-0.351152106288075
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	3/489	70/9376	0.821735319894829	RBX1/CDC42/RAP1A	-0.351152106288075
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	5/489	115/9376	0.833644527429537	FOS/GNAI2/GNG11/CREB3L2/GNG5	-0.421036307365155
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	5/489	115/9376	0.833644527429537	GNAS/GNAI2/GNG11/GNG5/APP	-0.421036307365155
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	4/489	95/9376	0.807318910773867	FOS/CTSL/ATP6V1F/CCL2	-0.442757561306915
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3/489	73/9376	0.787965375241617	MGST3/GSTP1/GSTO1	-0.426598361692009
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	3/489	73/9376	0.787965375241617	CCND1/GADD45B/RB1	-0.426598361692009
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	5/489	119/9376	0.805622862641989	FOS/EDN1/JAG1/CREB3L2/CCL2	-0.500548320342866
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	2/489	51/9376	0.75191467179919	PLD1/PLPP1	-0.416700696422616
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	4/489	98/9376	0.782605066566504	CALM1/DGKH/ITPKB/INPP4B	-0.507455249705973
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/489	27/9376	0.710141634477013	ACAT1	-0.353791682665562
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	4/489	99/9376	0.774699964884014	GNAS/CALM1/PRKCE/PPP1CA	-0.528612655184041
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/489	28/9376	0.684779433245691	DHFR	-0.391829100358678
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/489	28/9376	0.684779433245691	ATP6V1F	-0.391829100358678
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	4/489	102/9376	0.75191467179919	GNAS/ATP1B3/RAP1A/ATP2B4	-0.590921917724331
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3/489	79/9376	0.728119903704279	MGST3/GSTP1/GSTO1	-0.569222453527496
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	3/489	79/9376	0.728119903704279	ATP6V1F/AP2M1/AP2S1	-0.569222453527496
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/489	29/9376	0.661166349340667	CALM1	-0.428658944514202
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	6/489	148/9376	0.777317194495109	FOS/CCND1/JAG1/GADD45B/RB1/CTNNB1	-0.640510460244851
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	8/489	193/9376	0.794769912160802	GNAI2/ARRB1/CDC42/GNG11/STAT1/RAP1A/CCL2/GNG5	-0.675755938666603
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	2/489	56/9376	0.684779433245691	CCND1/ARRB1	-0.554961787777829
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/489	30/9376	0.639127471029311	SDHA	-0.464369876880046
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/489	30/9376	0.639127471029311	PIGT	-0.464369876880046
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/489	30/9376	0.639127471029311	DHFR	-0.464369876880046
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	6/489	150/9376	0.766952965235174	CCND1/TGFBR2/GADD45B/RB1/CTNNA1/CTNNB1	-0.674908602103697
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	10/489	238/9376	0.805622862641989	RASGRP3/PLD1/CALM1/KDR/CDC42/GNG11/EFNA5/ANGPT2/RAP1A/GNG5	-0.712476527676875
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	5/489	128/9376	0.748977505112474	AMPD1/NT5E/GUK1/NUDT16/PDE4B	-0.670743068952966
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	4/489	105/9376	0.73043139546207	BCL10/UBE2I/GADD45B/CARD11	-0.651573101257013
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	3/489	82/9376	0.701481370641927	MGST3/GSTP1/GSTO1	-0.636853454192336
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/489	31/9376	0.618510455834818	PFKL	-0.499041095846178
NA	NA	hsa04981	Folate transport and metabolism	1/489	31/9376	0.618510455834818	DHFR	-0.499041095846178
NA	NA	hsa04081	Hormone signaling	9/489	219/9376	0.787965375241617	CSH1/GNAS/CGA/CSH2/GNAI2/GNG11/ITGAV/PRKG1/GNG5	-0.744757206024753
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	3/489	83/9376	0.693029787863109	PRDX1/SOD1/FAR1	-0.65890042795364
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	3/489	83/9376	0.693029787863109	POLR2L/PCBP1/G3BP1	-0.65890042795364
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	4/489	109/9376	0.703626573610251	PRKCE/TBC1D4/CREB3L2/PPP1CA	-0.730037898432591
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	2/489	60/9376	0.639127471029311	KDR/CDC42	-0.657774731607235
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	5/489	133/9376	0.720820456048096	S1PR1/CCND1/TGFBR2/MDM2/GADD45B	-0.760615926999939
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	5/489	133/9376	0.720820456048096	HLA-C/HLA-A/NFATC1/KLRD1/TNFRSF10B	-0.760615926999939
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	4/489	110/9376	0.697229968395613	HSP90AB1/GNAI2/CPEB4/CDC25B	-0.749247941618698
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/489	34/9376	0.563936003849392	POLR2L	-0.597492193115236
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	7/489	181/9376	0.741529110034008	CALM1/MRC1/CTSS/LAMP1/BCL10/STAT1/LAMP2	-0.823640202136504
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/489	35/9376	0.547823546596553	PFKL	-0.628648316694379
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	2/489	63/9376	0.608692829551725	COLGALT1/ACAT1	-0.73098044177453
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	2/489	63/9376	0.608692829551725	RBX1/POLR2L	-0.73098044177453
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/489	63/9376	0.608692829551725	GADD45B/CTNNB1	-0.73098044177453
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	5/489	138/9376	0.694703772857947	CALM1/RPS6/PRKAR1A/SOCS2/PPP1CA	-0.847489798627559
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/489	36/9376	0.53260622585776	UGP2	-0.659057358050698
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/489	36/9376	0.53260622585776	UGP2	-0.659057358050698
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/489	36/9376	0.53260622585776	SSBP1	-0.659057358050698
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	3/489	90/9376	0.639127471029311	FOS/NFATC1/STAT1	-0.806906503592117
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	2/489	65/9376	0.589963819411672	GNAS/CREB3L2	-0.778113897620778
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	2/489	65/9376	0.589963819411672	CGA/ARRB1	-0.778113897620778
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/489	37/9376	0.518211462996739	UGP2	-0.688762692031565
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1/489	38/9376	0.504574319233667	UGP2	-0.71780397004062
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/489	38/9376	0.504574319233667	ATP1B3	-0.71780397004062
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/489	39/9376	0.491636516176393	DHFR	-0.746217533203006
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	6/489	168/9376	0.684779433245691	CSH1/CSH2/CCND1/IL6ST/STAT1/SOCS2	-0.967050177041362
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/489	41/9376	0.467654247094618	PGAM1	-0.801292427417957
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	5/489	149/9376	0.643416917143602	GNAS/PLD1/ARF1/DGKH/PLPP1	-1.02916755627409
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/489	42/9376	0.456519622163794	ACAT1	-0.828012881595378
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	3/489	100/9376	0.57521472392638	IL6ST/CCL2/TNFRSF10B	-1.00173203483767
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/489	43/9376	0.445902886764636	ACAT1	-0.854224375779934
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/489	44/9376	0.435768730247258	MPG	-0.879951228589025
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	2/489	78/9376	0.491636516176393	ITPKB/INPP4B	-1.05752186471636
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	5/489	158/9376	0.606766586420233	RPS6/LAMTOR5/ATP6V1F/DDIT4/LAMTOR2	-1.1692922806137
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/489	48/9376	0.39945466939332	ACAT1	-0.978440953597842
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/489	48/9376	0.39945466939332	ATP1B3	-0.978440953597842
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	2/489	80/9376	0.479345603271984	KDR/RPS6	-1.09700587602377
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/489	50/9376	0.383476482617587	LAP3	-1.02529637467268
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/489	54/9376	0.355070817238506	FANCC	-1.11485102455503
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	4/489	144/9376	0.53260622585776	IL6ST/SMARCAD1/JARID2/CTNNB1	-1.32580224155618
Organismal Systems	Digestive system	hsa04976	Bile secretion	2/489	90/9376	0.426084980686208	GNAS/ATP1B3	-1.28326687241718
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/489	59/9376	0.324980070014904	NT5E	-1.22002022792427
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	8/489	254/9376	0.603899972626121	GNAS/CALM1/KDR/ITPKB/EDNRB/NFATC1/ATP2B4/VDAC1	-1.50120213866577
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	5/489	178/9376	0.538590565474139	CCND1/RBX1/SKP1/NFATC1/CTNNB1	-1.45784800406419
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	1/489	63/9376	0.304346414775863	GGT5	-1.29951404791953
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	2/489	100/9376	0.383476482617587	CD9/CD34	-1.45389068872935
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	5/489	195/9376	0.491636516176393	ACTB/ACTG1/VWF/HDAC2/VDAC1	-1.68270946247046
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	1/489	72/9376	0.26630311292888	ISG15	-1.46592094980979
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	2/489	109/9376	0.351813286805126	FOS/STAT1	-1.59663729524261
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	3/489	143/9376	0.402248058689777	SSB/ACTN4/SNRPB	-1.68958511139194
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	3/489	144/9376	0.39945466939332	CCND1/TRA2B/CTNNB1	-1.70349797006952
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	4/489	183/9376	0.419099981002827	RAN/REXO2/RRP7A/NOP10	-1.86149032425539
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/489	86/9376	0.222951443382318	SCN3A	-1.69805598310593
NA	NA	hsa04082	Neuroactive ligand signaling	4/489	199/9376	0.385403500118178	GNAS/GNAI2/GNG11/GNG5	-2.05555325382202
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	1/489	99/9376	0.193674991221004	KRT18	-1.89184881224067
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	2/489	154/9376	0.249010702998433	UGP2/DHFR	-2.20416461814326
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	9/489	370/9376	0.466390316697065	CSH1/CALCRL/CGA/S1PR1/CSH2/EDN1/TSPO/EDNRB/ADM	-2.45652433328435
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	6/489	298/9376	0.386050150286161	CSH1/CSH2/IL6ST/TGFBR2/CCL2/TNFRSF10B	-2.52643667942936
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	4/489	449/9376	0.170813578003379	CALM1/ARRB1/ANO2/PRKG1	-4.22362218764683