category subcategory ID Description GeneRatio BgRatio FoldEnrichment geneName zScore Organismal Systems Immune system hsa04672 Intestinal immune network for IgA production 3/31 50/9376 18.1470967741935 CCR10/CCR9/TNFRSF13B 7.00171981492306 Organismal Systems Digestive system hsa04979 Cholesterol metabolism 2/31 52/9376 11.6327543424318 ABCB11/APOE 4.4281584418498 Human Diseases Substance dependence hsa05031 Amphetamine addiction 2/31 69/9376 8.76671341748481 FOS/FOSB 3.72935564434294 Organismal Systems Development and regeneration hsa04360 Axon guidance 3/31 184/9376 4.9312762973352 SEMA5B/TRPC1/SEMA6B 3.10180365815503 Human Diseases Infectious disease: bacterial hsa05133 Pertussis 2/31 78/9376 7.75516956162117 FOS/C4BPA 3.45036958944209 Organismal Systems Immune system hsa04657 IL-17 signaling pathway 2/31 94/9376 6.43514070006863 FOS/FOSB 3.05021721759413 Human Diseases Immune disease hsa05323 Rheumatoid arthritis 2/31 95/9376 6.36740237691002 FOS/ATP6V1G2 3.02834536744305 Organismal Systems Environmental adaptation hsa04714 Thermogenesis 3/31 235/9376 3.86108442004118 NDUFA8/ZNF516/CPT1B 2.55825941639798 Human Diseases Drug resistance: antineoplastic hsa01522 Endocrine resistance 2/31 99/9376 6.11013359400456 FOS/ABCB11 2.94389899487609 Environmental Information Processing Signaling molecules and interaction hsa04061 Viral protein interaction with cytokine and cytokine receptor 2/31 100/9376 6.04903225806452 CCR10/CCR9 2.9235101613636 Metabolism Glycan biosynthesis and metabolism hsa00533 Glycosaminoglycan biosynthesis - keratan sulfate 1/31 14/9376 21.6036866359447 B3GNT2 4.44325734749857 Organismal Systems Nervous system hsa04726 Serotonergic synapse 2/31 115/9376 5.26002805049088 TRPC1/DUSP1 2.64733724120913 Organismal Systems Endocrine system hsa04928 Parathyroid hormone synthesis, secretion and action 2/31 115/9376 5.26002805049088 FOS/NR4A2 2.64733724120913 Environmental Information Processing Signaling molecules and interaction hsa04060 Cytokine-cytokine receptor interaction 3/31 298/9376 3.04481489499892 CCR10/CCR9/TNFRSF13B 2.06606449795072 Metabolism Energy metabolism hsa00190 Oxidative phosphorylation 2/31 138/9376 4.3833567087424 ATP6V1G2/NDUFA8 2.30608432904994 Organismal Systems Development and regeneration hsa04380 Osteoclast differentiation 2/31 142/9376 4.25988187187642 FOS/FOSB 2.25438420104723 Human Diseases Cardiovascular disease hsa05418 Fluid shear stress and atherosclerosis 2/31 142/9376 4.25988187187642 FOS/DUSP1 2.25438420104723 Metabolism Glycan biosynthesis and metabolism hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series 1/31 28/9376 10.8018433179723 B3GNT2 2.99160501183071 Organismal Systems Excretory system hsa04966 Collecting duct acid secretion 1/31 28/9376 10.8018433179723 ATP6V1G2 2.99160501183071 Cellular Processes Transport and catabolism hsa04148 Efferocytosis 2/31 157/9376 3.85288678857613 STAB1/CPT1B 2.07620048816106 Human Diseases Endocrine and metabolic disease hsa04932 Non-alcoholic fatty liver disease 2/31 157/9376 3.85288678857613 FOS/NDUFA8 2.07620048816106 Metabolism Carbohydrate metabolism hsa00051 Fructose and mannose metabolism 1/31 35/9376 8.64147465437788 TKFC 2.60850302895721 Metabolism Glycan biosynthesis and metabolism hsa00512 Mucin type O-glycan biosynthesis 1/31 36/9376 8.40143369175627 GALNT18 2.56253907955792 Human Diseases Immune disease hsa05340 Primary immunodeficiency 1/31 38/9376 7.95925297113752 TNFRSF13B 2.47573592849166 Metabolism Lipid metabolism hsa00071 Fatty acid degradation 1/31 43/9376 7.0337584396099 CPT1B 2.28395922573943 Organismal Systems Immune system hsa04062 Chemokine signaling pathway 2/31 193/9376 3.13421360521478 CCR10/CCR9 1.72544483464779 Environmental Information Processing Membrane transport hsa02010 ABC transporters 1/31 45/9376 6.72114695340502 ABCB11 2.21565479784717 Human Diseases Cardiovascular disease hsa05415 Diabetic cardiomyopathy 2/31 205/9376 2.9507474429583 NDUFA8/CPT1B 1.62647151745324 Metabolism Glycan biosynthesis and metabolism hsa00514 Other types of O-glycan biosynthesis 1/31 49/9376 6.1724818959842 GALNT18 2.09075364775453 Human Diseases Substance dependence hsa05030 Cocaine addiction 1/31 49/9376 6.1724818959842 FOSB 2.09075364775453 Metabolism Lipid metabolism hsa00565 Ether lipid metabolism 1/31 51/9376 5.93042378241619 PAFAH2 2.03339499224357 Human Diseases Infectious disease: bacterial hsa05110 Vibrio cholerae infection 1/31 51/9376 5.93042378241619 ATP6V1G2 2.03339499224357 Environmental Information Processing Signal transduction hsa04340 Hedgehog signaling pathway 1/31 56/9376 5.40092165898617 SCUBE2 1.9024205445674 Human Diseases Cancer: overview hsa05208 Chemical carcinogenesis - reactive oxygen species 2/31 227/9376 2.66477191985221 FOS/NDUFA8 1.46237141383344 Metabolism Global and overview maps hsa01212 Fatty acid metabolism 1/31 57/9376 5.30616864742501 CPT1B 1.8781083295677 Metabolism Lipid metabolism hsa00561 Glycerolipid metabolism 1/31 65/9376 4.6531017369727 TKFC 1.70214719914994 Organismal Systems Endocrine system hsa04929 GnRH secretion 1/31 65/9376 4.6531017369727 TRPC1 1.70214719914994 Organismal Systems Endocrine system hsa04920 Adipocytokine signaling pathway 1/31 70/9376 4.32073732718894 CPT1B 1.60612318779646 Organismal Systems Endocrine system hsa04917 Prolactin signaling pathway 1/31 71/9376 4.25988187187642 FOS 1.58799701134861 Human Diseases Infectious disease: bacterial hsa05120 Epithelial cell signaling in Helicobacter pylori infection 1/31 71/9376 4.25988187187642 ATP6V1G2 1.58799701134861 Organismal Systems Immune system hsa04622 RIG-I-like receptor signaling pathway 1/31 72/9376 4.20071684587814 TKFC 1.57020185189331 Human Diseases Neurodegenerative disease hsa05012 Parkinson disease 2/31 268/9376 2.25710158883004 NDUFA8/DUSP1 1.20254986414642 Organismal Systems Endocrine system hsa03320 PPAR signaling pathway 1/31 76/9376 3.97962648556876 CPT1B 1.50211775720421 Human Diseases Infectious disease: parasitic hsa05140 Leishmaniasis 1/31 78/9376 3.87758478081059 FOS 1.46979745336954 Organismal Systems Nervous system hsa04721 Synaptic vesicle cycle 1/31 79/9376 3.82850142915476 ATP6V1G2 1.45403668878212 Human Diseases Cancer: specific types hsa05210 Colorectal cancer 1/31 87/9376 3.47645532072673 FOS 1.33654157961571 Organismal Systems Immune system hsa04610 Complement and coagulation cascades 1/31 88/9376 3.43695014662757 C4BPA 1.32282900762055 Organismal Systems Digestive system hsa04976 Bile secretion 1/31 90/9376 3.36057347670251 ABCB11 1.29598886583068 Human Diseases Cancer: overview hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer 1/31 90/9376 3.36057347670251 FOS 1.29598886583068 Environmental Information Processing Signal transduction hsa04010 MAPK signaling pathway 2/31 300/9376 2.01634408602151 FOS/DUSP1 1.03045962571062 Organismal Systems Immune system hsa04662 B cell receptor signaling pathway 1/31 91/9376 3.32364409783765 FOS 1.28285090307965 Organismal Systems Immune system hsa04658 Th1 and Th2 cell differentiation 1/31 93/9376 3.25216788067985 FOS 1.25711466230297 Organismal Systems Environmental adaptation hsa04713 Circadian entrainment 1/31 97/9376 3.11805786498171 FOS 1.20767460158222 Organismal Systems Endocrine system hsa04925 Aldosterone synthesis and secretion 1/31 98/9376 3.0862409479921 NR4A2 1.19571355160042 Human Diseases Cancer: overview hsa05231 Choline metabolism in cancer 1/31 99/9376 3.05506679700228 FOS 1.18390428876385 Organismal Systems Immune system hsa04640 Hematopoietic cell lineage 1/31 100/9376 3.02451612903226 MS4A1 1.17224314929197 Organismal Systems Digestive system hsa04972 Pancreatic secretion 1/31 102/9376 2.9652118912081 TRPC1 1.14935120552944 Human Diseases Infectious disease: parasitic hsa05142 Chagas disease 1/31 103/9376 2.93642342624491 FOS 1.13811367773365 Organismal Systems Endocrine system hsa04922 Glucagon signaling pathway 1/31 107/9376 2.82665058788062 CPT1B 1.09447982639173 Organismal Systems Immune system hsa04620 Toll-like receptor signaling pathway 1/31 109/9376 2.77478543947914 FOS 1.07341177926845 Organismal Systems Immune system hsa04659 Th17 cell differentiation 1/31 109/9376 2.77478543947914 FOS 1.07341177926845 Human Diseases Endocrine and metabolic disease hsa04931 Insulin resistance 1/31 109/9376 2.77478543947914 CPT1B 1.07341177926845 Environmental Information Processing Signal transduction hsa04350 TGF-beta signaling pathway 1/31 110/9376 2.74956011730205 TFR2 1.06305539762866 Organismal Systems Nervous system hsa04725 Cholinergic synapse 1/31 115/9376 2.63001402524544 FOS 1.01295033309187 Metabolism Global and overview maps hsa01200 Carbon metabolism 1/31 116/9376 2.60734149054505 TKFC 1.00324843027629 Organismal Systems Nervous system hsa04724 Glutamatergic synapse 1/31 116/9376 2.60734149054505 TRPC1 1.00324843027629 Genetic Information Processing Chromosome hsa03082 ATP-dependent chromatin remodeling 1/31 117/9376 2.58505652054039 MTA2 0.993647797319001 Environmental Information Processing Signal transduction hsa04668 TNF signaling pathway 1/31 119/9376 2.54161019246408 FOS 0.974742167494868 Environmental Information Processing Signal transduction hsa04152 AMPK signaling pathway 1/31 122/9376 2.47911158117398 CPT1B 0.947093677791232 Organismal Systems Immune system hsa04660 T cell receptor signaling pathway 1/31 122/9376 2.47911158117398 FOS 0.947093677791232 Organismal Systems Endocrine system hsa04935 Growth hormone synthesis, secretion and action 1/31 122/9376 2.47911158117398 FOS 0.947093677791232 Organismal Systems Endocrine system hsa04926 Relaxin signaling pathway 1/31 130/9376 2.32655086848635 FOS 0.877193635820676 Organismal Systems Nervous system hsa04728 Dopaminergic synapse 1/31 133/9376 2.27407227746786 FOS 0.852295591827571 Human Diseases Infectious disease: viral hsa05162 Measles 1/31 136/9376 2.22390891840607 FOS 0.828055412540229 Cellular Processes Cell growth and death hsa04210 Apoptosis 1/31 137/9376 2.20767600659289 FOS 0.820115595015291 Human Diseases Infectious disease: bacterial hsa05135 Yersinia infection 1/31 138/9376 2.1916783543712 FOS 0.812243879335126 Human Diseases Neurodegenerative disease hsa05010 Alzheimer disease 2/31 388/9376 1.55902893249085 NDUFA8/APOE 0.647732142320232 Organismal Systems Endocrine system hsa04915 Estrogen signaling pathway 1/31 139/9376 2.17591088419587 FOS 0.80443909875572 Human Diseases Endocrine and metabolic disease hsa04936 Alcoholic liver disease 1/31 144/9376 2.10035842293907 CPT1B 0.766380335365153 Human Diseases Cancer: specific types hsa05224 Breast cancer 1/31 148/9376 2.04359197907585 FOS 0.737029090092098 Organismal Systems Nervous system hsa04723 Retrograde endocannabinoid signaling 1/31 149/9376 2.02987659666594 NDUFA8 0.72983535082241 Organismal Systems Endocrine system hsa04921 Oxytocin signaling pathway 1/31 154/9376 1.96397151235861 FOS 0.694686458706381 Cellular Processes Transport and catabolism hsa04145 Phagosome 1/31 155/9376 1.95130072840791 ATP6V1G2 0.687814773289967 Cellular Processes Cell growth and death hsa04218 Cellular senescence 1/31 157/9376 1.92644339428806 HIPK4 0.674223118553708 Environmental Information Processing Signal transduction hsa04150 mTOR signaling pathway 1/31 158/9376 1.91425071457738 ATP6V1G2 0.667501632670033 Human Diseases Infectious disease: viral hsa05161 Hepatitis B 1/31 163/9376 1.85553136750445 FOS 0.634608721224769 Environmental Information Processing Signal transduction hsa04310 Wnt signaling pathway 1/31 178/9376 1.69916636462486 GPC4 0.542401220324108 Human Diseases Substance dependence hsa05034 Alcoholism 1/31 191/9376 1.58351629792265 FOSB 0.469252857788719 Human Diseases Infectious disease: viral hsa05167 Kaposi sarcoma-associated herpesvirus infection 1/31 196/9376 1.54312047399605 FOS 0.442567687232036 Human Diseases Infectious disease: bacterial hsa05130 Pathogenic Escherichia coli infection 1/31 200/9376 1.51225806451613 FOS 0.42174887412991 Human Diseases Cancer: overview hsa05202 Transcriptional misregulation in cancer 1/31 201/9376 1.50473439255336 LYL1 0.416614827903901 Human Diseases Infectious disease: viral hsa05170 Human immunodeficiency virus 1 infection 1/31 214/9376 1.41332529394031 FOS 0.352273973831768 Human Diseases Cardiovascular disease hsa05417 Lipid and atherosclerosis 1/31 216/9376 1.40023894862605 FOS 0.342748308395943 Human Diseases Cancer: overview hsa05207 Chemical carcinogenesis - receptor activation 1/31 217/9376 1.39378623457708 FOS 0.338020624892845 Human Diseases Infectious disease: viral hsa05166 Human T-cell leukemia virus 1 infection 1/31 224/9376 1.35023041474654 FOS 0.305560135634945 Environmental Information Processing Signal transduction hsa04024 cAMP signaling pathway 1/31 226/9376 1.33828147302312 FOS 0.296482263643889 Environmental Information Processing Signal transduction hsa04014 Ras signaling pathway 1/31 238/9376 1.27080509623204 RASAL1 0.243723029006297 Human Diseases Infectious disease: viral hsa05171 Coronavirus disease - COVID-19 1/31 238/9376 1.27080509623204 FOS 0.243723029006297 Human Diseases Infectious disease: bacterial hsa05132 Salmonella infection 1/31 248/9376 1.21956295525494 FOS 0.201824518291812 Cellular Processes Transport and catabolism hsa04142 Lysosome biogenesis 1/31 250/9376 1.2098064516129 ATP6V1G2 0.193653541249168 Human Diseases Neurodegenerative disease hsa05020 Prion disease 1/31 275/9376 1.09982404692082 NDUFA8 0.0967684521542234 Human Diseases Neurodegenerative disease hsa05016 Huntington disease 1/31 308/9376 0.981985756179305 NDUFA8 -0.018514520604003 Human Diseases Infectious disease: viral hsa05165 Human papillomavirus infection 1/31 333/9376 0.908263101811489 ATP6V1G2 -0.0981717957749733 Human Diseases Neurodegenerative disease hsa05014 Amyotrophic lateral sclerosis 1/31 368/9376 0.8218793828892 NDUFA8 -0.200770889889444 Environmental Information Processing Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction 1/31 370/9376 0.81743679163034 CNR2 -0.206359744942949 Human Diseases Neurodegenerative disease hsa05022 Pathways of neurodegeneration - multiple diseases 1/31 480/9376 0.63010752688172 NDUFA8 -0.4791544852681