category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	15/110	227/9376	5.63235883059672	MT-ND2/MT-ND3/FOS/MT-CYB/MT-ND1/AKT3/MT-CO3/MT-CO2/MT-CO1/PRKD3/MT-ND4/MAPK1/MT-ATP6/HMOX1/MT-ND5	7.69775599945444
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	14/110	235/9376	5.07791102514507	RPS6KA2/MT-ND2/MT-ND3/MT-CYB/MT-ND1/MT-CO3/MT-CO2/ADCY3/MT-CO1/MT-ND4/MT-ATP6/MT-ND5/ADCY9/ARID1B	6.89780091082615
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	14/110	268/9376	4.45264586160109	MT-ND2/MT-ND3/MT-CYB/MT-ND1/MT-CO3/MT-CO2/MT-CO1/MT-ND4/SLC39A10/HSPA5/MT-ATP6/SNCA/MT-ND5/PRKN	6.2480393186172
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	10/110	138/9376	6.17654808959157	MT-ND2/MT-ND3/MT-CYB/MT-ND1/MT-CO3/MT-CO2/MT-CO1/MT-ND4/MT-ATP6/MT-ND5	6.67462160689173
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	12/110	205/9376	4.98944567627495	MT-ND2/MT-ND3/MT-CYB/PLCB1/MT-ND1/AKT3/MT-CO3/MT-CO2/MT-CO1/MT-ND4/MT-ATP6/MT-ND5	6.29240941752242
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	16/110	388/9376	3.51490159325211	MT-ND2/MT-ND3/MT-CYB/PLCB1/MT-ND1/AKT3/MT-CO3/MT-CO2/MT-CO1/MT-ND4/EIF2AK2/MAPK1/SLC39A10/MT-ATP6/SNCA/MT-ND5	5.51240553071502
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	15/110	362/9376	3.5318935208438	CCND3/CSH1/DDIT4/AREG/ITGA1/AKT3/PDGFD/LPAR3/CSH2/MAPK1/ITGB1/IL2RA/HSP90AB1/COL9A2/COL4A4	5.35274776306532
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	11/110	212/9376	4.42264150943396	PLCB1/AKT3/ADCY3/PRKD3/PDGFD/LPAR3/MAPK1/EVL/ITGB1/ADCY9/RAPGEF5	5.49190019533853
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	9/110	149/9376	5.14850518608908	MT-ND2/MT-ND3/PLCB1/MT-ND1/ADCY3/MT-ND4/MAPK1/MT-ND5/ADCY9	5.56147954313886
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	12/110	275/9376	3.71940495867769	MT-ND2/MT-ND3/MT-CYB/MT-ND1/MT-CO3/MT-CO2/MT-CO1/MT-ND4/MAPK1/HSPA5/MT-ATP6/MT-ND5	4.98690973856608
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	8/110	122/9376	5.5892697466468	CSH1/FOS/PLCB1/AKT3/ADCY3/CSH2/MAPK1/ADCY9	5.55897327135371
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	16/110	480/9376	2.84121212121212	MT-ND2/MT-ND3/MT-CYB/PLCB1/MT-ND1/MT-CO3/MT-CO2/MT-CO1/MT-ND4/HIP1/MAPK1/HSPA5/MT-ATP6/SNCA/MT-ND5/PRKN	4.51193557405567
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	8/110	139/9376	4.90568999345978	FKBP5/FOS/PLCB1/AKT3/ADCY3/MAPK1/HSP90AB1/ADCY9	5.05446891762621
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	6/110	75/9376	6.81890909090909	PLCB1/ADCY3/CGA/TG/HSPA5/ADCY9	5.51243161207704
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	12/110	308/9376	3.32089728453365	MT-ND2/MT-ND3/MT-CYB/PLCB1/MT-ND1/MT-CO3/MT-CO2/MT-CO1/MT-ND4/HIP1/MT-ATP6/MT-ND5	4.5124391214689
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	5/110	52/9376	8.1958041958042	ADCY3/CGA/FSHR/ADCY9/CYP19A1	5.6691207780395
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	13/110	368/9376	3.01106719367589	MT-ND2/MT-ND3/MT-CYB/MT-ND1/MT-CO3/MT-CO2/MT-CO1/MT-ND4/SRSF7/HSPA5/MT-ATP6/MT-ND5/PRKN	4.28817138943297
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	9/110	193/9376	3.97475270843147	PREX1/PLCB1/AKT3/CCL4/ADCY3/MAPK1/XCL2/ADCY9/CXCR4	4.5495984135038
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	5/110	59/9376	7.22342064714946	AKT3/ADCY3/CGA/PTGER3/ADCY9	5.22459881149622
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	7/110	130/9376	4.58965034965035	FOS/PLCB1/AKT3/ADCY3/MAPK1/ADCY9/COL4A4	4.49037604715408
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	5/110	65/9376	6.55664335664336	PLCB1/AKT3/CGA/MAPK1/KISS1	4.89786568360264
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	9/110	217/9376	3.5351487222455	CCND3/RPS6KA2/FOS/AKT3/ADCY3/MAPK1/NOTCH2/HSP90AB1/ADCY9	4.11666106744729
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	6/110	99/9376	5.16584022038568	FOS/AKT3/ADCY3/MAPK1/NOTCH2/ADCY9	4.53996244697299
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	9/110	227/9376	3.37941529835803	HLA-C/PLCB1/AKT3/CCL4/ADCY3/PTGER3/MAPK1/ADCY9/CXCR4	3.95395932352024
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	8/110	184/9376	3.70592885375494	SRGAP3/MAPK1/EPHA4/ROBO1/ITGB1/EPHA1/RASA1/CXCR4	4.03883499065058
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	11/110	333/9376	2.81561561561562	CCND3/HLA-C/ITGA1/AKT3/MAML2/EIF2AK2/MAPK1/NOTCH2/ITGB1/COL9A2/COL4A4	3.67557757768633
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	7/110	149/9376	4.00439292251373	PLCB1/AKT3/ADCY3/PDGFD/LPAR3/MAPK1/ADCY9	4.02768443779221
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	6/110	110/9376	4.64925619834711	RPS6KA2/AKT3/ADCY3/MAPK1/HSP90AB1/ADCY9	4.19459835162605
NA	NA	hsa04518	Integrin signaling	7/110	154/9376	3.87438016528926	CCND3/ITGA1/AKT3/PDGFD/ITGB1/COL9A2/COL4A4	3.9185720970012
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	6/110	115/9376	4.44711462450593	FOS/PLCB1/AKT3/ADCY3/MAPK1/ADCY9	4.0523928074772
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	6/110	115/9376	4.44711462450593	FOS/PLCB1/ADCY3/MAPK1/RUNX2/ADCY9	4.0523928074772
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	8/110	203/9376	3.35906851768921	CCND3/ITGA1/AKT3/PDGFD/MAPK1/ITGB1/COL9A2/COL4A4	3.70227530269942
NA	NA	hsa04517	IgSF CAM signaling	10/110	299/9376	2.85071450288842	AKT3/CASK/SRGAP3/MAPK1/ROBO1/ITGB1/CD96/TRIO/RASA1/SPTBN1	3.54355915850323
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	5/110	82/9376	5.19733924611973	HLA-C/KLRD1/HSPA5/KLRC1/HSP90AB1	4.15925451813671
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	5/110	87/9376	4.89864158829676	AREG/FOS/LEF1/AKT3/MAPK1	3.98037774154635
Organismal Systems	Immune system	hsa04611	Platelet activation	6/110	126/9376	4.05887445887446	PLCB1/AKT3/ADCY3/MAPK1/ITGB1/ADCY9	3.76627382722059
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	5/110	89/9376	4.78855975485189	ITGA1/CD44/ITGB1/COL9A2/COL4A4	3.9126162553972
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	5/110	89/9376	4.78855975485189	PLCB1/ADCY3/PDGFD/MAPK1/ADCY9	3.9126162553972
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	5/110	93/9376	4.58260019550342	FOS/MAML2/MAPK1/NOTCH2/IL2RA	3.78295763034262
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	5/110	93/9376	4.58260019550342	PLCB1/ADCY3/CGA/MAPK1/ADCY9	3.78295763034262
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	8/110	224/9376	3.04415584415584	CCND3/HLA-C/FOS/AKT3/ADCY3/MAPK1/IL2RA/ADCY9	3.37377285124351
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	8/110	226/9376	3.01721641190668	FOS/AKT3/ADCY3/CGA/PTGER3/FSHR/MAPK1/ADCY9	3.34450614526842
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	5/110	97/9376	4.39362699156514	FOS/PLCB1/ADCY3/MAPK1/ADCY9	3.66045622896046
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	6/110	138/9376	3.70592885375494	RPS6KA2/FOS/WIPF3/AKT3/MAPK1/ITGB1	3.48901447091734
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	5/110	100/9376	4.26181818181818	CCL4/IL2RA/XCL2/TNFRSF10A/CXCR4	3.57285352602554
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	5/110	101/9376	4.21962196219622	LEF1/PLCB1/ADCY3/MAPK1/ADCY9	3.54441398778389
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	5/110	106/9376	4.02058319039451	LEF1/AKT3/PDGFD/MAPK1/HSP90AB1	3.40753009060839
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	7/110	196/9376	3.04415584415584	HLA-C/FOS/LEF1/PREX1/AKT3/EIF2AK2/MAPK1	3.1510589699088
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	7/110	200/9376	2.98327272727273	FOS/WIPF3/MAPK1/ITGB1/MYO1F/TNFRSF10A/OCLN	3.08891934110085
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	5/110	110/9376	3.87438016528926	SMURF2/ACVR1B/ID2/MAPK1/DCN	3.3039254160149
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	4/110	71/9376	4.80204865556978	FOS/AKT3/CGA/MAPK1	3.50368044129898
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	6/110	157/9376	3.25744064852345	FOS/MT-CYB/AKT3/MT-CO3/MT-CO2/MT-CO1	3.10785030759939
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	7/110	205/9376	2.91050997782705	CCND3/HLA-C/RASA2/SP100/EIF2AK2/MAPK1/GTF2H2	3.01337878799605
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	7/110	216/9376	2.76228956228956	FOS/PLCB1/AKT3/MAPK1/HSPA5/HSP90AB1/TNFRSF10A	2.85490880853267
NA	NA	hsa04081	Hormone signaling	7/110	219/9376	2.7244499792445	CSH1/PLCB1/ADCY3/CGA/CSH2/FSHR/ADCY9	2.81340260061611
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	3/110	45/9376	5.68242424242424	HLA-C/KLRD1/KLRC1	3.43043152371191
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	4/110	87/9376	3.91891327063741	MT-CYB/MT-CO3/MT-CO2/MT-CO1	2.98010913514757
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	6/110	180/9376	2.84121212121212	HLA-C/AKT3/SRSF5/SP100/EIF2AK2/SRSF7	2.7175430294494
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	7/110	232/9376	2.5717868338558	ITGA1/AKT3/PDGFD/MAPK1/PIP4K2A/ITGB1/CXCR4	2.64122477991834
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	5/110	133/9376	3.20437457279563	HLA-C/KLRD1/MAPK1/KLRC1/TNFRSF10A	2.78959123407557
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	5/110	134/9376	3.18046132971506	PLCB1/ADCY3/MAPK1/PLA2G6/ADCY9	2.7698333422478
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	7/110	238/9376	2.50695187165775	AKT3/RASA2/PDGFD/MAPK1/PLA2G6/RASA1/RAPGEF5	2.56565417145726
Human Diseases	Infectious disease: viral	hsa05162	Measles	5/110	136/9376	3.13368983957219	CCND3/FOS/AKT3/EIF2AK2/IL2RA	2.73086725865907
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	4/110	93/9376	3.66608015640274	AKT3/ITGB1/FHIT/COL4A4	2.81518107530599
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	8/110	298/9376	2.2882245271507	CSH1/CCL4/CSH2/ACVR1B/IL2RA/XCL2/TNFRSF10A/CXCR4	2.4622970191214
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	5/110	140/9376	3.04415584415584	PLCB1/AKT3/ADCY3/MAPK1/ADCY9	2.65504503138658
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	8/110	300/9376	2.2729696969697	RPS6KA2/AREG/FOS/AKT3/RASA2/PDGFD/MAPK1/RASA1	2.44155932930501
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	3/110	54/9376	4.73535353535354	HLA-C/CGA/TG	2.99923071952895
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	4/110	98/9376	3.47903525046382	PLCB1/ADCY3/PRKD3/ADCY9	2.68784604095211
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	4/110	99/9376	3.44389348025712	PLCB1/ADCY3/PLA2G6/ADCY9	2.66337258219237
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	4/110	99/9376	3.44389348025712	FOS/AKT3/PDGFD/MAPK1	2.66337258219237
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	4/110	100/9376	3.40945454545455	ITGA1/CD9/CD44/IL2RA	2.63921153438631
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	5/110	148/9376	2.87960687960688	FOS/LEF1/AKT3/MAPK1/NOTCH2	2.51119202544792
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	4/110	101/9376	3.37569756975698	PLCB1/AKT3/MAPK1/COL4A4	2.61535540378999
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	3/110	59/9376	4.33405238828968	LEF1/AKT3/MAPK1	2.79895689732991
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/110	24/9376	7.1030303030303	HS6ST2/XYLT1	3.26163028481517
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	6/110	204/9376	2.50695187165775	CD44/AKT3/MAPK1/DCN/DDX5/ITGB1	2.37092750964951
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	4/110	103/9376	3.31015004413063	FOS/PLCB1/AKT3/MAPK1	2.56852917758114
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	5/110	154/9376	2.76741440377804	PLCB1/AKT3/ADCY3/MAPK1/ADCY9	2.40947277959862
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	5/110	154/9376	2.76741440377804	FOS/PLCB1/ADCY3/MAPK1/ADCY9	2.40947277959862
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	4/110	105/9376	3.24709956709957	ITGA1/ADCY3/ITGB1/ADCY9	2.52283883664129
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	5/110	155/9376	2.74956011730205	LEF1/PLCB1/ADCY3/MAPK1/ADCY9	2.39299362119938
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	3/110	62/9376	4.12434017595308	AKT3/ADCY3/ADCY9	2.68919239405292
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	5/110	157/9376	2.71453387376954	CCND3/HLA-C/AKT3/MAPK1/ZFP36L2	2.36042291099415
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	4/110	109/9376	3.1279399499583	FOS/AKT3/CCL4/MAPK1	2.43466307091149
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	4/110	109/9376	3.1279399499583	FOS/MAPK1/IL2RA/HSP90AB1	2.43466307091149
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	3/110	65/9376	3.93398601398601	PLCB1/ADCY3/ADCY9	2.58614211705553
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	3/110	67/9376	3.81655359565807	RPS6KA2/PLCB1/MAPK1	2.52080782796679
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	5/110	166/9376	2.56736035049288	PLCB1/AKT3/ADCY3/MAPK1/ADCY9	2.21987703307272
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	3/110	68/9376	3.76042780748663	LEF1/AKT3/MAPK1	2.48907793865162
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	4/110	116/9376	2.93918495297806	TXK/ITGB1/OCLN/CXCR4	2.2896999082034
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	4/110	116/9376	2.93918495297806	PLCB1/ADCY3/MAPK1/ADCY9	2.2896999082034
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	5/110	168/9376	2.53679653679654	CCND3/CSH1/AKT3/CSH2/IL2RA	2.18989953595192
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	5/110	170/9376	2.50695187165775	LEF1/AKT3/MAPK1/HMOX1/ARID1B	2.16035036438026
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	5/110	173/9376	2.46347871781398	CCND3/AKT3/EIF2AK2/MAPK1/TNFRSF10A	2.11680369348764
Human Diseases	Cancer: specific types	hsa05218	Melanoma	3/110	73/9376	3.50286425902864	AKT3/PDGFD/MAPK1	2.33896136958959
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	3/110	73/9376	3.50286425902864	AKT3/MAPK1/FHIT	2.33896136958959
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	4/110	122/9376	2.7946348733234	PLCB1/AKT3/MAPK1/NOTCH2	2.17383763504713
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	6/110	233/9376	2.19492781896215	ITGA1/DCN/ITGB1/COL9A2/COL4A4/SPTBN1	2.01238515741715
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	4/110	125/9376	2.72756363636364	PLCB1/AKT3/MAPK1/ABCC1	2.1185101682899
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	3/110	76/9376	3.36459330143541	PLCB1/ADCY3/ADCY9	2.2550574458076
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	3/110	78/9376	3.27832167832168	FOS/MAPK1/ITGB1	2.20142252450461
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	3/110	78/9376	3.27832167832168	FOS/MAPK1/ITGB1	2.20142252450461
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	3/110	80/9376	3.19636363636364	AKT3/PDGFD/MAPK1	2.14949784283243
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	2/110	37/9376	4.60737100737101	LEF1/MAPK1	2.39539598722278
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	6/110	248/9376	2.06217008797654	FOS/LEF1/AKT3/MAPK1/HSP90AB1/TNFRSF10A	1.8470043766332
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	4/110	137/9376	2.48865295288653	FOS/AKT3/MAPK1/TNFRSF10A	1.91239278303813
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	6/110	254/9376	2.013457408733	PLCB1/ADCY3/PTGER3/PDGFD/ADCY9/CXCR4	1.78407521168211
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	4/110	138/9376	2.47061923583663	RPS6KA2/ADCY3/MAPK1/ADCY9	1.89621090293015
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	3/110	86/9376	2.97336152219873	AREG/AKT3/MAPK1	2.00301341191283
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	3/110	86/9376	2.97336152219873	PLCB1/ADCY3/ADCY9	2.00301341191283
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	3/110	86/9376	2.97336152219873	ITGA1/LEF1/ITGB1	2.00301341191283
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	7/110	323/9376	1.84722769490571	DDIT4/CD44/ABCB1/MAPK1/NOTCH2/HMOX1/ABCC1	1.68826640214635
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	4/110	142/9376	2.40102432778489	FOS/AKT3/HSP90AB1/HMOX1	1.83286613269924
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	3/110	89/9376	2.87313585291113	ADCY3/GPHN/ADCY9	1.93447174147948
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	3/110	90/9376	2.84121212121212	AKT3/ADCY3/ADCY9	1.91225838187608
Organismal Systems	Digestive system	hsa04976	Bile secretion	3/110	90/9376	2.84121212121212	ADCY3/ABCB1/ADCY9	1.91225838187608
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	3/110	90/9376	2.84121212121212	FOS/AKT3/MAPK1	1.91225838187608
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	4/110	144/9376	2.36767676767677	AKT3/ACVR1B/ID2/MAPK1	1.80199113760328
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	3/110	91/9376	2.80999000999001	FOS/AKT3/MAPK1	1.89034795936852
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	5/110	205/9376	2.07893569844789	CCND3/HLA-C/CD44/AKT3/EIF2AK2	1.70176653618551
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	2/110	44/9376	3.87438016528926	ADCY3/ADCY9	2.08218356105553
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	3/110	93/9376	2.74956011730205	SMURF2/LEF1/MAPK1	1.84740452026936
Organismal Systems	Digestive system	hsa04970	Salivary secretion	3/110	93/9376	2.74956011730205	PLCB1/ADCY3/ADCY9	1.84740452026936
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/110	45/9376	3.78828282828283	ABCB1/ABCC1	2.04274811848614
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	3/110	94/9376	2.72030947775629	FOS/MAPK1/HSP90AB1	1.82635652104988
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	4/110	150/9376	2.2729696969697	LEF1/AKT3/ABCB1/MAPK1	1.71235104300727
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	5/110	214/9376	1.99150382327952	HLA-C/FOS/AKT3/MAPK1/CXCR4	1.59860795214565
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	3/110	98/9376	2.60927643784787	AKT3/MAPK1/PLA2G6	1.7448268641834
NA	NA	hsa03272	Virion - Hepatitis viruses	2/110	48/9376	3.55151515151515	CD9/OCLN	1.93090245379212
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/110	48/9376	3.55151515151515	PLCB1/AKT3	1.93090245379212
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	4/110	156/9376	2.18554778554779	AKT3/EIF2AK2/MAPK1/OCLN	1.6268658211483
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	4/110	157/9376	2.17162709901563	CCND3/AREG/LEF1/ID2	1.61299551438891
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	4/110	158/9376	2.15788262370541	RPS6KA2/DDIT4/AKT3/MAPK1	1.59922864798676
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	3/110	102/9376	2.50695187165775	PLCB1/ADCY3/ADCY9	1.66725395067587
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	2/110	51/9376	3.34260249554367	ADCY3/ADCY9	1.82765871746828
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	2/110	53/9376	3.21646655231561	PLCB1/ADCY9	1.76301946594188
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	3/110	110/9376	2.32462809917355	AKT3/MAPK1/HMOX1	1.52257954479261
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	7/110	370/9376	1.61257985257985	CSH1/CGA/PTGER3/LPAR3/CSH2/FSHR/KISS1	1.3098857952492
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	3/110	112/9376	2.28311688311688	AKT3/MAPK1/ITGB1	1.48837302519457
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	2/110	60/9376	2.84121212121212	AKT3/MAPK1	1.55883641822528
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/110	60/9376	2.84121212121212	PLCB1/MAPK1	1.55883641822528
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	3/110	119/9376	2.14881588999236	FOS/AKT3/MAPK1	1.37411985730079
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	2/110	62/9376	2.74956011730205	MAML2/NOTCH2	1.50588716190348
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	3/110	120/9376	2.13090909090909	RPS6KA2/AKT3/MAPK1	1.3584463089431
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	2/110	63/9376	2.70591630591631	PLA2G6/PTGIS	1.48019531914325
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	5/110	250/9376	1.70472727272727	SMURF2/HLA-C/WIPF3/IL2RA/CXCR4	1.23051435319656
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	3/110	122/9376	2.09597615499255	FOS/AKT3/MAPK1	1.32755372597049
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	5/110	253/9376	1.68451311534315	PLCB1/CD44/AKT3/MAPK1/ITGB1	1.20256630113056
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	4/110	187/9376	1.823237724842	PLCB1/TXNIP/MAPK1/HSP90AB1	1.23893286649515
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/110	17/9376	5.01390374331551	PCDH9	1.80473118753907
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	3/110	128/9376	1.99772727272727	ADCY3/FHIT/ADCY9	1.23830820593778
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	2/110	69/9376	2.47061923583663	AKT3/MAPK1	1.33584405966152
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	2/110	70/9376	2.43532467532468	AKT3/MAPK1	1.31326835607911
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	2/110	71/9376	2.40102432778489	AKT3/MAPK1	1.29107804232146
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	3/110	133/9376	1.92262474367738	FOS/PLCB1/AKT3	1.167562867521
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	4/110	201/9376	1.6962460425147	ID2/DDX5/RUNX2/JMJD1C	1.08716024974114
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	2/110	73/9376	2.33524283935243	ELL2/CXCR4	1.24780295575378
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	2/110	75/9376	2.2729696969697	AKT3/MAPK1	1.20592335937243
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	2/110	75/9376	2.2729696969697	CCND3/TNFRSF10A	1.20592335937243
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/110	21/9376	4.05887445887446	XYLT1	1.52892167483941
Human Diseases	Cancer: specific types	hsa05214	Glioma	2/110	76/9376	2.24306220095694	AKT3/MAPK1	1.1854794099976
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	2/110	77/9376	2.21393152302243	AKT3/MAPK1	1.16535236205253
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	2/110	77/9376	2.21393152302243	AKT3/MAPK1	1.16535236205253
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	3/110	142/9376	1.80076824583867	FOS/AKT3/MAPK1	1.04759137213499
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	2/110	78/9376	2.18554778554779	PLCB1/PIP4K2A	1.14553253116743
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/110	26/9376	3.27832167832168	PLA2G6	1.26745265040709
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/110	26/9376	3.27832167832168	ABCC1	1.26745265040709
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	2/110	88/9376	1.93719008264463	TFPI/CLU	0.962373708453477
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/110	28/9376	3.04415584415584	GPHN	1.18023774466725
Human Diseases	Substance dependence	hsa05032	Morphine addiction	2/110	91/9376	1.87332667332667	ADCY3/ADCY9	0.912099672193377
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	3/110	160/9376	1.59818181818182	HLA-C/ITGB1/OCLN	0.831491472482647
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/110	30/9376	2.84121212121212	PLA2G6	1.10049328565519
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/110	30/9376	2.84121212121212	ABCC1	1.10049328565519
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	3/110	163/9376	1.56876742889013	FOS/AKT3/MAPK1	0.798111957457002
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/110	31/9376	2.74956011730205	HSPA5	1.06305539762866
NA	NA	hsa04981	Folate transport and metabolism	1/110	31/9376	2.74956011730205	ABCC1	1.06305539762866
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	3/110	168/9376	1.52207792207792	EIF2AK2/HSP90AB1/TNFRSF10A	0.743948969114935
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	3/110	169/9376	1.51307154384077	DDIT4/AKT3/MAPK1	0.733327618922588
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	2/110	98/9376	1.73951762523191	PLCB1/PIP4K2A	0.801807687414691
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	2/110	99/9376	1.72194674012856	ITGA1/ITGB1	0.786782717411755
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	3/110	174/9376	1.46959247648903	HSPA5/HSP90AB1/PRKN	0.681224835689094
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	2/110	103/9376	1.65507502206531	COL9A2/COL4A4	0.728342001834158
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	2/110	103/9376	1.65507502206531	PLCB1/COL4A4	0.728342001834158
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	3/110	178/9376	1.43656792645557	CCND3/LEF1/PLCB1	0.640694443306691
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	2/110	105/9376	1.62354978354978	SMURF2/PRKN	0.700064934171632
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	2/110	105/9376	1.62354978354978	AKT3/MAPK1	0.700064934171632
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/110	37/9376	2.3036855036855	PLCB1	0.865683906021256
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	2/110	107/9376	1.59320305862362	PLCB1/AKT3	0.672379807108216
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/110	38/9376	2.24306220095694	MAPK1	0.836553184898411
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	2/110	109/9376	1.56396997497915	RPS6KA2/AKT3	0.645261099220172
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/110	39/9376	2.18554778554779	HLA-C	0.80832036493243
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	1/110	41/9376	2.07893569844789	MAPK1	0.754338307087987
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	1/110	42/9376	2.02943722943723	HMOX1	0.72849479000211
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	2/110	115/9376	1.48237154150198	PLCB1/MAPK1	0.5670710661658
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	3/110	195/9376	1.31132867132867	PLCB1/AKT3/MAPK1	0.47866013948171
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	1/110	44/9376	1.93719008264463	B4GALNT3	0.678894812604073
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/110	44/9376	1.93719008264463	GTF2H2	0.678894812604073
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	1/110	44/9376	1.93719008264463	HLA-C	0.678894812604073
NA	NA	hsa04082	Neuroactive ligand signaling	3/110	199/9376	1.28497030607583	PLCB1/ADCY3/ADCY9	0.442702132568437
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/110	46/9376	1.85296442687747	HMOX1	0.631836696870037
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	2/110	122/9376	1.3973174366617	AKT3/TBC1D1	0.481269816893843
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/110	47/9376	1.81353965183752	MAPK1	0.60918042636699
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	1/110	50/9376	1.70472727272727	CXCR4	0.544370031252178
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	1/110	51/9376	1.67130124777184	PLA2G6	0.523737842792995
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	1/110	52/9376	1.63916083916084	OSBPL5	0.503554556960943
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	2/110	133/9376	1.28174982911825	AKT3/MAPK1	0.356548684243706
NA	NA	hsa04382	Cornified envelope formation	3/110	217/9376	1.17838290741517	S100A6/OCLN/COL4A4	0.289664256621452
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	2/110	138/9376	1.23530961791831	AKT3/MAPK1	0.303407334942953
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	1/110	56/9376	1.52207792207792	MGAT5	0.426930535475036
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	1/110	56/9376	1.52207792207792	SMURF2	0.426930535475036
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	2/110	142/9376	1.20051216389245	SMURF2/PRKN	0.262316611570738
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	2/110	144/9376	1.18383838383838	LEF1/AKT3	0.242217420268683
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	2/110	144/9376	1.18383838383838	PLCB1/AKT3	0.242217420268683
Organismal Systems	Digestive system	hsa04978	Mineral absorption	1/110	61/9376	1.3973174366617	HMOX1	0.339193050451143
NA	NA	hsa04519	Cadherin signaling	5/110	404/9376	1.05490549054905	LEF1/PCDH9/MAPK1/EVL/MYO1F	0.122912954764466
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	1/110	63/9376	1.35295815295815	PHYKPL	0.306255942363761
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/110	63/9376	1.35295815295815	GTF2H2	0.306255942363761
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	1/110	63/9376	1.35295815295815	LEF1	0.306255942363761
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	3/110	238/9376	1.07440794499618	FOS/EIF2AK2/MAPK1	0.126682914072765
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/110	66/9376	1.29146005509642	CYP19A1	0.258888049086495
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	2/110	155/9376	1.09982404692082	HLA-C/ITGB1	0.136536209965851
Genetic Information Processing	Transcription	hsa03040	Spliceosome	3/110	243/9376	1.05230078563412	SRSF5/SRSF7/DDX5	0.0899995739377968
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	2/110	157/9376	1.08581354950782	MAPK1/PLA2G6	0.118140721178431
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	2/110	158/9376	1.0789413118527	CCND3/DBF4	0.109031092478525
Organismal Systems	Endocrine system	hsa04924	Renin secretion	1/110	69/9376	1.23530961791831	PLCB1	0.213744623773112
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	1/110	69/9376	1.23530961791831	FOS	0.213744623773112
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	1/110	70/9376	1.21766233766234	AKT3	0.19915289221757
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	1/110	70/9376	1.21766233766234	HLA-C	0.19915289221757
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	2/110	170/9376	1.0027807486631	ITGB1/OCLN	0.00398645205634398
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	1/110	78/9376	1.09277389277389	CNOT7	0.089642537830247
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	1/110	78/9376	1.09277389277389	ITGB1	0.089642537830247
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	1/110	83/9376	1.02694414019715	CCL4	0.026863416155912
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	2/110	181/9376	0.941838272225013	AKT3/MAPK1	-0.0860867976689241
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/110	86/9376	0.991120507399577	PLCB1	-0.00901291657385252
Cellular Processes	Cell motility	hsa04814	Motor proteins	2/110	194/9376	0.878725398313027	KIF26B/MYO1F	-0.18596786727471
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	1/110	95/9376	0.897224880382775	FOS	-0.109695355532685
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	1/110	104/9376	0.81958041958042	PLA2G6	-0.201580936968429
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	1/110	105/9376	0.811774891774892	CCL4	-0.211322017063195
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	1/110	117/9376	0.728515928515929	ARID1B	-0.321951961519783
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	1/110	154/9376	0.553482880755608	GPHN	-0.608725855206545
Human Diseases	Substance dependence	hsa05034	Alcoholism	1/110	191/9376	0.446263683960019	MAPK1	-0.842395315696151
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	1/110	250/9376	0.340945454545455	OSBPL5	-1.15076584815967
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/110	449/9376	0.189835999190119	ADCY3	-1.91681049066622