category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	26/324	268/9376	2.80744426018058	MT-CO1/MT-CO3/MT-CYB/MT-ND4/MT-ND3/MT-ND2/MT-ATP6/MT-CO2/MT-ND1/MT-ND5/MAOA/UQCRH/TUBB4B/HSPA5/TUBA1B/LRRK2/MT-ND6/SLC18A2/GNAI1/NDUFA6/ATP5F1B/GNAS/ATF4/ATP5F1A/GNAI2/UBC	5.67945508904255
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	17/324	138/9376	3.56485954553587	MT-CO1/MT-CO3/MT-CYB/MT-ND4/MT-ND3/MT-ND2/MT-ATP6/MT-CO2/MT-ND1/MT-ND5/UQCRH/MT-ND6/NDUFA6/ATP5F1B/PPA1/ATP5F1A/ATP6V1A	5.74248702477125
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	19/324	170/9376	3.23427741466957	EZR/CLDN4/NEDD4L/OCLN/PARD6B/LLGL2/AFDN/MYL12B/TUBA1B/CCND1/CLDN1/CLDN3/ARHGAP17/MYL6/ITGB1/PRKAA2/MYH14/GATA4/MYL12A	5.56175612197278
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	21/324	227/9376	2.67710882688856	MT-CO1/MT-CO3/MT-CYB/MT-ND4/MT-ND3/MT-ND2/MT-ATP6/FOS/MT-CO2/MT-ND1/MT-ND5/MGST1/MET/UQCRH/HMOX1/MT-ND6/NDUFA6/ATP5F1B/ATP5F1A/MGST3/HGF	4.8391961966628
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	14/324	116/9376	3.49255002128565	EZR/CLDN4/OCLN/AFDN/MYL12B/RAPGEF3/CLDN1/CLDN3/VAV2/GNAI1/ITGB1/PECAM1/GNAI2/MYL12A	5.11038070319759
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	23/324	275/9376	2.42029180695847	MT-CO1/MT-CO3/MT-CYB/MT-ND4/MT-ND3/MT-ND2/MT-ATP6/MT-CO2/MT-ND1/MT-ND5/HSPA8/EGR1/UQCRH/TUBB4B/C7/HSPA5/TUBA1B/MT-ND6/LAMC1/NDUFA6/ATP5F1B/ATF4/ATP5F1A	4.52256942342013
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	19/324	205/9376	2.68208370972599	MT-CO1/MT-CO3/MT-CYB/MT-ND4/MT-ND3/MT-ND2/MT-ATP6/MT-CO2/MT-ND1/MT-ND5/CD36/PDK4/UQCRH/MPC1/MT-ND6/NDUFA6/SLC2A1/ATP5F1B/ATP5F1A	4.6068286529962
NA	NA	hsa03272	Virion - Hepatitis viruses	8/324	48/9376	4.82304526748971	CLDN4/OCLN/CD9/CLDN1/CLDN3/CD81/DPP4/SCARB1	5.02367645178129
NA	NA	hsa04517	IgSF CAM signaling	22/324	299/9376	2.12923737561419	GRIP1/CDH1/EZR/CADM1/PARD6B/CABLES1/AFDN/ANK3/TUBB4B/MYL12B/TUBA1B/SRGAP3/DYNLL1/CXADR/VAV2/LMO7/MYL6/ITGB1/MYH14/BAIAP2/MTSS1/MYL12A	3.75435677554117
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	9/324	75/9376	3.47259259259259	GPX3/CGA/PAX8/HSP90B1/HSPA5/FXYD2/GNAS/ATF4/ATP1A1	4.0672816187936
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	14/324	160/9376	2.5320987654321	CDH1/CLDN4/CADM1/OCLN/SDC1/HLA-C/ALCAM/CXADR/CLDN1/ITGB8/CLDN3/ITGB1/IGSF11/PECAM1	3.69795303814266
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	18/324	235/9376	2.21654846335697	MT-CO1/MT-CO3/MT-CYB/MT-ND4/MT-ND3/MT-ND2/MT-ATP6/MT-CO2/MT-ND1/MT-ND5/RPS6KA2/UQCRH/MT-ND6/NDUFA6/ATP5F1B/GNAS/ATP5F1A/PRKAA2	3.5731591626299
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	7/324	49/9376	4.13403880070547	FOSB/MAOA/SLC18A2/GNAI1/GNAS/ATF4/GNAI2	4.16118755737702
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	17/324	217/9376	2.26705353587074	UGT2B7/FOS/MGST1/HSP90AA1/RPS6KA2/HSP90AB1/HSP90B1/KLF5/CCND1/JAG1/GNAI1/GNAS/ATF4/GNAI2/KLF4/MGST3/PTGES3	3.57261875070739
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	16/324	200/9376	2.31506172839506	FOS/EZR/CLDN4/IL1R1/IL18/OCLN/TUBB4B/TNFSF10/TUBA1B/CLDN1/CLDN3/TMBIM6/ITGB1/BAIAP2L1/MYH14/BAIAP2	3.5564794608807
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	7/324	50/9376	4.05135802469136	CD36/MET/IL18/SDC1/CD81/PECAM1/HGF	4.09276053367453
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	24/324	362/9376	1.91855944342132	CSH1/CSH2/CSHL1/GNGT1/MET/FGFR2/LAMB3/HSP90AA1/GH2/HSP90AB1/HSP90B1/YWHAZ/AREG/GNG11/MCL1/SGK1/CCND1/ITGB8/NTRK2/LAMC1/ITGB1/ATF4/PRKAA2/HGF	3.3720083814486
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	6/324	38/9376	4.5692007797271	NEDD4L/SCNN1A/SGK1/FXYD2/ATP1A1/SFN	4.17082255410804
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	9/324	93/9376	2.80047789725209	CDH1/SMURF1/MET/AFDN/PTPRB/MYL12B/LMO7/BAIAP2/MYL12A	3.30119336860907
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	12/324	149/9376	2.33059905543127	MT-ND4/MT-ND3/MT-ND2/GABRP/MT-ND1/MT-ND5/GNGT1/GNG11/MT-ND6/GNAI1/NDUFA6/GNAI2	3.09739045279296
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	9/324	97/9376	2.68499427262314	FOS/GNGT1/RPS6KA5/RASD1/GNG11/PER2/GNAI1/GNAS/GNAI2	3.15587344785913
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	4/324	22/9376	5.26150392817059	ALDH3B1/MAOA/HAL/CNDP2	3.78583272855665
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	13/324	174/9376	2.1620547750816	UBE2D2/HSPA8/CALR/HSP90AA1/HSP90AB1/HSP90B1/SEC62/HSPA5/CAPN1/RPN1/ATF4/DNAJA1/TRAM1	2.9271567521356
NA	NA	hsa04382	Cornified envelope formation	15/324	217/9376	2.00034135518007	KRT19/CLDN4/KRT18/SPTLC3/LAMB3/OCLN/HAL/S100A10/CAPN1/CLDN1/S100A6/CLDN3/FURIN/ST14/JUP	2.82058980259926
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	22/324	368/9376	1.73000536768653	MT-CO1/MT-CO3/MT-CYB/GPX3/MT-ND4/MT-ND3/MT-ND2/MT-ATP6/MT-CO2/MT-ND1/MT-ND5/UQCRH/TUBB4B/HSPA5/NUP214/TUBA1B/HNRNPA2B1/MT-ND6/NDUFA6/ATP5F1B/ATF4/ATP5F1A	2.70284813531308
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	11/324	139/9376	2.29007904787281	FOS/KRT19/HSPA8/KRT18/HSP90AA1/HSP90AB1/HSP90B1/GNAI1/GNAS/ATF4/GNAI2	2.89897266889391
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	6/324	52/9376	3.33903133903134	HSD17B2/CGA/CYP19A1/HSD3B1/GNAS/SCARB1	3.19979717549214
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	11/324	140/9376	2.27372134038801	CDH1/GNGT1/EGR1/GNG11/CCND1/APLNR/JAG1/GNAI1/SLC8A1/GNAI2/PRKAA2	2.87264759393624
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	11/324	142/9376	2.24169709615719	FOS/IL1R1/MGST1/SDC1/HSP90AA1/HSP90AB1/HSP90B1/HMOX1/PECAM1/PRKAA2/MGST3	2.8206602169701
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	8/324	87/9376	2.66099049240812	MT-CO1/MT-CO3/MT-CYB/MT-CO2/UQCRH/FXYD2/SLC8A1/ATP1A1	2.94461257264761
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	19/324	308/9376	1.78515311848645	MT-CO1/MT-CO3/MT-CYB/GPX3/MT-ND4/MT-ND3/MT-ND2/MT-ATP6/MT-CO2/MT-ND1/MT-ND5/UQCRH/TUBB4B/TUBA1B/MT-ND6/NDUFA6/ATP5F1B/ATP5F1A/POLR2L	2.65069545333299
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	8/324	89/9376	2.60119295325288	GABRP/GNGT1/GABARAPL1/GNG11/GNAI1/GNAI2/GLUL/SLC6A12	2.87135454729139
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	16/324	248/9376	1.86698526483473	FOS/DYNC2LI1/IL18/HSP90AA1/HSP90AB1/HSP90B1/TUBB4B/ANXA2/MYL12B/TNFSF10/S100A10/TUBA1B/AHNAK/DYNLL1/DYNLRB1/MYL12A	2.61779486637298
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	9/324	110/9376	2.36767676767677	SMURF1/ID3/ID1/SMAD6/SMAD9/BMP5/ID2/EMP3/IGSF1	2.72972900906266
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	4/324	28/9376	4.13403880070547	ST3GAL6/B3GNT3/FUT9/GCNT2	3.14202693268104
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	14/324	212/9376	1.91101793617517	CDH1/MET/FGFR2/ID1/PARD6B/AFDN/RAPGEF3/VAV2/GNAI1/ITGB1/GNAS/SKAP1/GNAI2/HGF	2.53827217125326
Cellular Processes	Cell motility	hsa04814	Motor proteins	13/324	194/9376	1.93916253022782	KIF12/DYNC2LI1/KIF13B/TUBB4B/MYL12B/TUBA1B/DYNLL1/MYO9A/BICDL1/MYL6/MYH14/DYNLRB1/MYL12A	2.50068419129203
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	9/324	115/9376	2.26473429951691	FOS/EGR1/SLC34A2/PDE4D/SGK1/GNAI1/GNAS/ATF4/GNAI2	2.5816962593065
Organismal Systems	Digestive system	hsa04978	Mineral absorption	6/324	61/9376	2.84638737097753	SLC34A2/HMOX1/MT2A/FXYD2/SLC8A1/ATP1A1	2.73704652378113
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	9/324	116/9376	2.24521072796935	DLGAP1/SLC1A1/GNGT1/SHANK2/GNG11/GNAI1/GNAS/GNAI2/GLUL	2.55300829322851
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	11/324	157/9376	2.02752221435873	CDH1/WWC1/ID1/PARD6B/LLGL2/YWHAZ/AREG/BMP5/MOB1B/CCND1/ID2	2.45632036654419
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	7/324	82/9376	2.47034025895815	HSPA8/CALR/HLA-C/HSP90AA1/HSP90AB1/HSPA5/NFYC	2.52993469823835
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	9/324	122/9376	2.13479052823315	CSH1/CSH2/FOS/CSHL1/GH2/GNAI1/GNAS/ATF4/GNAI2	2.38680391002088
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	10/324	144/9376	2.00960219478738	POU5F1/ID3/FGFR2/ID1/IL6ST/DLX5/LIFR/SMAD9/KLF4/ID2	2.30977408736344
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	21/324	388/9376	1.56624665903016	MT-CO1/MT-CO3/MT-CYB/MT-ND4/MT-ND3/MT-ND2/MT-ATP6/MT-CO2/MT-ND1/MT-ND5/UQCRH/TUBB4B/EIF2AK2/APOE/TUBA1B/CAPN1/MT-ND6/NDUFA6/ATP5F1B/ATF4/ATP5F1A	2.1551418191226
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	14/324	232/9376	1.74627501064283	SCIN/EZR/FGFR2/SSH2/C7/MYL12B/ITGB8/DIAPH1/VAV2/ABI2/ITGB1/MYH14/BAIAP2/MYL12A	2.17751248484612
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	6/324	69/9376	2.51637144390768	FOS/FOSB/MAOA/SLC18A2/GNAS/ATF4	2.39172452213206
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	7/324	89/9376	2.27604383409627	FREM2/CD36/LAMB3/SDC1/ITGB8/LAMC1/ITGB1	2.28827778571719
Organismal Systems	Digestive system	hsa04976	Bile secretion	7/324	90/9376	2.25075445816187	UGT2B7/ABCC3/FXYD2/SLC2A1/GNAS/ATP1A1/SCARB1	2.25561433130181
Human Diseases	Substance dependence	hsa05032	Morphine addiction	7/324	91/9376	2.22602089268756	GABRP/GNGT1/PDE4D/GNG11/GNAI1/GNAS/GNAI2	2.22337892048713
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	6/324	73/9376	2.37848807711821	UGT2B7/MGST1/ALDH3B1/MAOA/MGST3/CYP3A5	2.23686000485481
NA	NA	hsa04081	Hormone signaling	13/324	219/9376	1.71779694458538	CSH1/CSH2/CGA/CSHL1/GNGT1/GH2/SMAD9/RAPGEF3/GNG11/CRH/GNAI1/GNAS/GNAI2	2.03344732289021
NA	NA	hsa04518	Integrin signaling	10/324	154/9376	1.87910854577521	FREM2/CDH1/MET/LAMB3/FLNB/CCND1/ITGB8/LAMC1/ITGB1/HGF	2.08101961607432
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	9/324	133/9376	1.95822890559733	FOS/GNGT1/MAOA/GNG11/SLC18A2/GNAI1/GNAS/ATF4/GNAI2	2.10559326175342
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	10/324	155/9376	1.86698526483473	CD36/FCGR2B/CALR/HLA-C/TUBB4B/TUBA1B/ITGB1/SCARB1/ATP6V1A/STX18	2.05908571210665
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	7/324	94/9376	2.15497767270817	FOS/FOSB/LCN2/HSP90AA1/HSP90AB1/HSP90B1/IL17RB	2.12913208312715
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	10/324	156/9376	1.85501741057297	CLDN4/OCLN/YWHAZ/EIF2AK2/MX1/CCND1/CLDN1/CLDN3/CD81/SCARB1	2.03731258336734
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	8/324	115/9376	2.01309715512614	GNGT1/MAOA/RAPGEF3/GNG11/SLC18A2/GNAI1/GNAS/GNAI2	2.06803052364616
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	10/324	157/9376	1.84320201305339	ATP11A/CD36/CALR/NR1H2/CD24/BSG/GULP1/SGK1/SLC2A1/PECAM1	2.01569781054973
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	13/324	224/9376	1.6794532627866	FOS/ELK4/FDPS/IL1R1/CALR/HLA-C/EGR1/MSX1/ZFP36/CCND1/ANAPC4/SLC2A1/ATF4	1.9472040429324
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	6/324	76/9376	2.28460038986355	EZR/KCNJ16/GNAI1/GNAS/GNAI2/ATP1A1	2.1272534761324
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	12/324	203/9376	1.7106367451195	MET/LAMB3/FLNB/MYL12B/CCND1/ITGB8/DIAPH1/VAV2/LAMC1/ITGB1/HGF/MYL12A	1.9365372392354
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	4/324	41/9376	2.82324601023788	CDH1/DAPK1/RPS6KA5/CCND1	2.21343060061017
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	5/324	59/9376	2.45239589872358	CGA/FABP4/GNAI1/GNAS/GNAI2	2.11718516679237
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	11/324	184/9376	1.73000536768653	MET/PARD6B/SEMA3B/SSH2/MYL12B/SRGAP3/GNAI1/ITGB1/GNAI2/RGS3/MYL12A	1.89197689215707
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	13/324	233/9376	1.61458167752874	FBLN1/SDC1/ANK3/BGN/ITGB8/DIAPH1/SYNE2/NEBL/LBR/ITGB1/ATP1A1/MYH14/JUP	1.79721104862516
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	10/324	168/9376	1.72251616696061	CSH1/CSH2/CSHL1/IL20RA/CSF2RA/GH2/IL6ST/LIFR/MCL1/CCND1	1.7877443965984
Human Diseases	Substance dependence	hsa05034	Alcoholism	11/324	191/9376	1.66660202960377	FOSB/GNGT1/MAOA/GNG11/CRH/NTRK2/SLC18A2/GNAI1/GNAS/ATF4/GNAI2	1.76087937073687
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	23/324	480/9376	1.38662551440329	MT-CO1/MT-CO3/MT-CYB/GPX3/MT-ND4/MT-ND3/MT-ND2/MT-ATP6/MT-CO2/MT-ND1/MT-ND5/UQCRH/TUBB4B/HSPA5/TUBA1B/CAPN1/LRRK2/MT-ND6/NDUFA6/ATP5F1B/ATF4/ATP5F1A/UBC	1.64512769305722
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	5/324	65/9376	2.22602089268756	LPIN3/AGPAT5/DGKH/DGKI/LIPG	1.87647272726361
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	7/324	106/9376	1.91101793617517	FGFR2/HSP90AA1/HSP90AB1/HSP90B1/CCND1/SPINT1/ATF4	1.78453826062143
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	6/324	86/9376	2.01894918173988	RIMS2/FXYD2/SLC2A1/GNAS/ATF4/ATP1A1	1.79589013227409
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	5/324	66/9376	2.19229330340441	HSD17B2/UGT2B7/CYP19A1/HSD3B1/CYP3A5	1.83893383116163
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	8/324	130/9376	1.78081671415005	FOS/GNGT1/RXFP1/GNG11/GNAI1/GNAS/ATF4/GNAI2	1.69601505690477
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	9/324	154/9376	1.69119769119769	RPS6KA5/RAPGEF3/FXYD2/GNAI1/SLC8A1/GNAS/ATF4/GNAI2/ATP1A1	1.63619835216057
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	9/324	155/9376	1.68028673835125	RASD1/HSD3B1/CCND1/CRH/GNAI1/GNAS/ATF4/GNAI2/SCARB1	1.61567763593044
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	3/324	31/9376	2.80047789725209	GLDC/PCCA/GLUL	1.8996118016449
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	12/324	226/9376	1.53654539495247	FOS/CGA/AFDN/PDE4D/RAPGEF3/CRH/VAV2/FXYD2/GNAI1/GNAS/GNAI2/ATP1A1	1.54467107785867
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	15/324	298/9376	1.45662440964454	CSH1/CSH2/CSHL1/IL1R1/IL20RA/IL18/CSF2RA/GH2/IL6ST/GDF15/LIFR/TNFSF10/IL17RB/BMP5/CXCL14	1.51550731599217
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	9/324	157/9376	1.65888181174805	MT-CO1/MT-CO3/MT-CYB/FOS/MT-CO2/UQCRH/NDUFA6/ATF4/PRKAA2	1.57507525455528
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/324	16/9376	3.61728395061728	ALDH3B1/MAOA	1.98225161187127
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	4/324	52/9376	2.22602089268756	CD36/APOE/SCARB1/LIPG	1.67719778869685
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	5/324	73/9376	1.98207339759851	BICD1/MX1/SERINC5/BST2/FURIN	1.59360152719812
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4/324	53/9376	2.18402049848591	FXYD2/SLC8A1/GNAS/ATP1A1	1.63532917406555
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	12/324	238/9376	1.45907251789605	FOS/ISG15/IL6ST/C7/EIF2AK2/MX1/RPLP2/RPL35/RPL36/RPS4X/RPL11/RPS26	1.35715692511402
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	11/324	216/9376	1.47370827617741	FOS/CD36/HSPA8/IL18/HSP90AA1/HSP90AB1/HSP90B1/HSPA5/TNFSF10/VAV2/ATF4	1.33252689016336
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	3/324	37/9376	2.34634634634635	RIMKLB/ASRGL1/GLUL	1.5523632079052
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	3/324	37/9376	2.34634634634635	ALDH3B1/MAOA/HGD	1.5523632079052
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/324	37/9376	2.34634634634635	IDO2/IL18/F2RL1	1.5523632079052
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	3/324	37/9376	2.34634634634635	PAX8/CDH1/CCND1	1.5523632079052
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5/324	79/9376	1.83153617752774	UGT2B7/MGST1/ALDH3B1/MGST3/CYP3A5	1.40413592051464
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	2/324	19/9376	3.0461338531514	GLDC/BCKDHB	1.68899512947235
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	3/324	38/9376	2.28460038986355	NT5E/NT5C2/NNMT	1.50113165655773
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	6/324	103/9376	1.68572455951097	SLC15A1/SLC1A1/DPP4/FXYD2/SLC8A1/ATP1A1	1.32386608748932
Organismal Systems	Nervous system	hsa04730	Long-term depression	4/324	60/9376	1.92921810699588	CRH/GNAI1/GNAS/GNAI2	1.36604315641114
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	14/324	300/9376	1.35045267489712	FOS/ELK4/PTPRR/IL1R1/MET/HSPA8/FGFR2/RPS6KA5/RPS6KA2/MECOM/AREG/NTRK2/ATF4/HGF	1.16715526532059
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	6/324	107/9376	1.6227068189685	SIK2/PKM/SLC2A1/GNAS/ATF4/PRKAA2	1.22558924137733
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	12/324	253/9376	1.37256624213146	IL1R1/UBE2D2/IL18/RPS6KA5/FNBP1/MYL12B/CAPN1/DIAPH1/ITGB1/UBC/CAPNS1/MYL12A	1.1365297153994
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	10/324	205/9376	1.41162300511894	SCIN/HLA-C/IL6ST/YWHAZ/EIF2AK2/PKM/CCND1/ATF4/GTF2H2/HNRNPK	1.12733786270556
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	6/324	109/9376	1.59293238192321	CD36/NR1H2/RPS6KA2/OGT/SLC2A1/PRKAA2	1.17797129417859
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	3/324	42/9376	2.06701940035273	IDO2/ACMSD/MAOA	1.3111395966117
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	15/324	333/9376	1.30352574797019	ISG15/LAMB3/PARD6B/LLGL2/HLA-C/EIF2AK2/PKM/MX1/CCND1/ITGB8/LAMC1/JAG1/ITGB1/GNAS/ATP6V1A	1.06695784255604
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	6/324	110/9376	1.57845117845118	HSP90AA1/RPS6KA2/HSP90AB1/GNAI1/ANAPC4/GNAI2	1.15452349521656
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	3/324	43/9376	2.01894918173988	CD36/PLA2G5/SCARB1	1.26695733568959
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	4/324	65/9376	1.78081671415005	HSD3B1/GNAS/ATF4/SCARB1	1.19507039222009
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/324	23/9376	2.51637144390768	FXYD2/ATP1A1	1.37746292594057
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	6/324	112/9376	1.55026455026455	HSPA8/LAMB3/LAMC1/GNAI1/ITGB1/GNAI2	1.10832503673787
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	3/324	44/9376	1.97306397306397	DYNC2LI1/DYNLL1/GNAS	1.22395721649705
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	5/324	89/9376	1.62574559578305	TUBB4B/TUBA1B/GNAI1/GNAS/GNAI2	1.12212426256878
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	7/324	137/9376	1.47859781923042	FOS/PARP4/TNFSF10/TUBA1B/CAPN1/MCL1/ATF4	1.06758972695211
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	7/324	138/9376	1.46788334227948	FOS/IL18/ARHGEF28/RPS6KA2/VAV2/ITGB1/BAIAP2	1.04754820856483
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	6/324	115/9376	1.50982286634461	FOS/GNGT1/GNG11/GNAI1/ATF4/GNAI2	1.04069905232549
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/324	46/9376	1.88727858293076	UGT2B7/CP/HMOX1	1.1412583374951
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	8/324	166/9376	1.39461549903317	FXYD2/GNAI1/SLC8A1/ATF4/GNAI2/ATP1A1/GTF2I/GATA4	0.970474745525464
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	4/324	70/9376	1.65361552028219	UGT2B7/MGST1/MGST3/CYP3A5	1.03842640468468
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	4/324	70/9376	1.65361552028219	EPAS1/MET/SLC2A1/HGF	1.03842640468468
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	2/324	26/9376	2.22602089268756	HNF1B/HNF4G	1.18430785640637
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	4/324	71/9376	1.63032516084159	MET/FGFR2/PKM/SLC2A1	1.00860588906695
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	9/324	196/9376	1.32879818594104	FOS/GNGT1/HLA-C/IL6ST/EIF2AK2/ZFP36/GNG11/CCND1/UBC	0.880079649087032
Human Diseases	Cancer: specific types	hsa05218	Melanoma	4/324	73/9376	1.58565871807881	CDH1/MET/CCND1/HGF	0.950343049541433
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	3/324	50/9376	1.7362962962963	MAOA/CNDP2/AMD1	0.987587952048668
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	5/324	98/9376	1.47644242882338	HSD3B1/GNAS/ATF4/ATP1A1/SCARB1	0.896978749798703
NA	NA	hsa04082	Neuroactive ligand signaling	9/324	199/9376	1.30876605248465	GABRP/SLC1A1/GNGT1/GNG11/SLC18A2/GNAI1/GNAS/GNAI2/SLC6A12	0.832897557436012
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/324	28/9376	2.06701940035273	DHFR/ALPP	1.06973905136299
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	5/324	99/9376	1.46152886893628	FOS/SLC44A3/SLC44A1/DGKH/DGKI	0.873370585858676
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	10/324	227/9376	1.27481372708979	IL1R1/GNGT1/CALR/HLA-C/GNG11/CCND1/GNAI1/GNAS/ATF4/GNAI2	0.792958406516106
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	5/324	100/9376	1.44691358024691	IL20RA/IL18/IL6ST/TNFSF10/CXCL14	0.850019820022904
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	5/324	100/9376	1.44691358024691	IL1R1/CD36/CD9/CSF2RA/CD24	0.850019820022904
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/324	29/9376	1.99574286930609	WWC1/MOB1B	1.01600525284501
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	4/324	76/9376	1.5230669265757	CD36/FABP4/UBC/FABP5	0.866180601055428
Organismal Systems	Immune system	hsa04611	Platelet activation	6/324	126/9376	1.37801293356849	MYL12B/GNAI1/ITGB1/GNAS/GNAI2/MYL12A	0.808177836502523
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	9/324	204/9376	1.27668845315904	EZR/MET/SDC1/ANK3/GPC3/CCND1/VAV2/ITGB1/HGF	0.755892379019861
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/324	30/9376	1.92921810699588	ABCC3/DHFR	0.964386836212868
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	4/324	78/9376	1.48401392845837	FOS/GNAI1/ITGB1/GNAI2	0.812075224002023
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	7/324	154/9376	1.31537598204265	FOS/CCND1/GNAI1/MYL6/GNAS/GNAI2/PRKAA2	0.746555824333065
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	5/324	103/9376	1.40477046625914	FOS/CALR/GNAI1/GNAS/GNAI2	0.781453553129076
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	5/324	104/9376	1.39126305792972	LPIN3/AGPAT5/DGKH/DGKI/PLA2G5	0.75907497453627
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/324	31/9376	1.86698526483473	ALDH3B1/CNDP2	0.914721276748714
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/324	31/9376	1.86698526483473	SEC62/HSPA5	0.914721276748714
NA	NA	hsa04981	Folate transport and metabolism	2/324	31/9376	1.86698526483473	ABCC3/DHFR	0.914721276748714
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	4/324	79/9376	1.46522894202219	SLC1A1/SLC18A2/SLC6A12/ATP6V1A	0.78558779089872
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	2/324	32/9376	1.80864197530864	PCCA/BCKDHB	0.866863518044835
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	3/324	56/9376	1.55026455026455	SMURF1/EVC/CCND1	0.781346125819295
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	3/324	56/9376	1.55026455026455	HSPA8/IL18/EEF1A1	0.781346125819295
NA	NA	hsa04519	Cadherin signaling	16/324	404/9376	1.14607016257181	GABRP/KRT19/CDH1/TMC5/MET/KRT18/WWC1/AFDN/TMC4/YWHAZ/MOB1B/PRICKLE2/VAV2/ABI2/FAT1/JUP	0.567797444278027
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	5/324	109/9376	1.32744365160267	FOS/IL1R1/HSP90AA1/HSP90AB1/IL6ST	0.650528177931291
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/324	34/9376	1.70225127087872	PER2/PRKAA2	0.776064703435109
Human Diseases	Infectious disease: viral	hsa05162	Measles	6/324	136/9376	1.27668845315904	FOS/HSPA8/FCGR2B/EIF2AK2/MX1/CCND1	0.61490832759155
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	3/324	59/9376	1.47143753923415	GPX3/MGST1/MGST3	0.687223480879299
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	4/324	85/9376	1.36180101670298	ADK/NT5E/NT5C2/GDA	0.633919171742625
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/324	12/9376	2.41152263374486	FCGR2B	0.925621934624631
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	4/324	86/9376	1.34596612115992	ITGB8/SLC8A1/ITGB1/JUP	0.609762640008531
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	7/324	168/9376	1.20576131687243	HSP90AA1/HSP90AB1/EIF2AK2/TNFSF10/CAPN1/RNF103-CHMP3/GLUL	0.509121675190757
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	4/324	91/9376	1.27201193867861	FOS/FCGR2B/CD81/VAV2	0.493291439147583
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	2/324	39/9376	1.48401392845837	GLDC/DHFR	0.573023396157014
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	8/324	201/9376	1.15177200417665	ELK4/PAX8/MET/PROM1/SPINT1/PER2/ID2/JUP	0.411502551155249
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	4/324	93/9376	1.24465684322315	CGA/EGR1/GNAS/ATF4	0.448580651651295
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	4/324	93/9376	1.24465684322315	LAMB3/CCND1/LAMC1/ITGB1	0.448580651651295
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	3/324	67/9376	1.29574350469873	RPS6KA2/RAPGEF3/ATF4	0.459607357144603
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/324	15/9376	1.92921810699588	ALPP	0.681377897060504
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	5/324	122/9376	1.18599473790731	CCND1/FXYD2/SLC2A1/ATP1A1/GATA4	0.391202567025003
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	2/324	41/9376	1.41162300511894	GLDC/MAOA	0.499712573250884
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	6/324	150/9376	1.15753086419753	CDH1/MET/FGFR2/CCND1/HGF/JUP	0.36795137531936
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	3/324	68/9376	1.27668845315904	CCND1/PER2/JUP	0.433214690307596
Organismal Systems	Endocrine system	hsa04924	Renin secretion	3/324	69/9376	1.25818572195384	GNAI1/GNAS/GNAI2	0.407228139874521
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	2/324	42/9376	1.37801293356849	CP/HMOX1	0.464497388772078
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/324	16/9376	1.80864197530864	FUT9	0.612440946120604
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	3/324	70/9376	1.24021164021164	CD36/SLC2A1/PRKAA2	0.381634312784816
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	3/324	70/9376	1.24021164021164	HLA-C/CXADR/CCND1	0.381634312784816
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	9/324	238/9376	1.09430438842204	GNGT1/MET/FGFR2/AFDN/GNG11/NTRK2/PLA2G5/HGF/RALGAPA2	0.278792236142067
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	3/324	71/9376	1.22274387063119	FOS/CGA/CCND1	0.356420453488211
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	4/324	99/9376	1.16922309514902	FOS/CCND1/JAG1/GNAS	0.320228015404005
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	4/324	99/9376	1.16922309514902	ITGB8/SLC8A1/ITGB1/PRKAA2	0.320228015404005
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/324	17/9376	1.70225127087872	GLUL	0.54826199435929
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/324	17/9376	1.70225127087872	MYH14	0.54826199435929
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	2/324	44/9376	1.31537598204265	B4GALNT3/RPN1	0.3966920159581
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	2/324	44/9376	1.31537598204265	GTF2I/GTF2H2	0.3966920159581
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	2/324	44/9376	1.31537598204265	HLA-C/ICA1	0.3966920159581
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	5/324	128/9376	1.1304012345679	PDE4D/ADK/NT5E/NT5C2/GDA	0.281027388747274
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	8/324	214/9376	1.081804545979	FOS/GNGT1/CALR/HLA-C/GNG11/GNAI1/BST2/GNAI2	0.229020865839473
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	3/324	73/9376	1.18924403855911	MET/CCND1/HGF	0.307084571884743
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	6/324	158/9376	1.09892170651664	LPIN3/DEPTOR/RPS6KA2/SGK1/PRKAA2/ATP6V1A	0.237239861648396
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	4/324	102/9376	1.13483418058581	FXYD2/GNAS/ATP1A1/PLA2G5	0.259031398897952
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	4/324	103/9376	1.12381637300731	IL1R1/LAMB3/LAMC1/GNAS	0.239041018768829
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	5/324	133/9376	1.08790494755407	GABARAPL1/TNFSF10/SGK1/CCND1/PRKAA2	0.193160594679889
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	4/324	105/9376	1.10241034685479	SMURF1/GABARAPL1/ATF4/UBC	0.19964620842485
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	4/324	105/9376	1.10241034685479	ITGB8/SLC8A1/ITGB1/GNAS	0.19964620842485
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	2/324	48/9376	1.20576131687243	PCCA/BCKDHB	0.270380863927949
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/324	48/9376	1.20576131687243	FXYD2/ATP1A1	0.270380863927949
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/324	20/9376	1.44691358024691	LBR	0.378511704584781
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	3/324	78/9376	1.11301044634378	DCPS/BTG2/TOB1	0.189608145826502
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	3/324	78/9376	1.11301044634378	CDH1/MET/ITGB1	0.189608145826502
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	3/324	78/9376	1.11301044634378	FOS/EEF1A1/ITGB1	0.189608145826502
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/324	21/9376	1.37801293356849	CSGALNACT1	0.328080396710135
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	3/324	80/9376	1.08518518518519	MET/FGFR2/HGF	0.144759434705664
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	2/324	51/9376	1.13483418058581	GNAS/ATP6V1A	0.182661297674958
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	6/324	170/9376	1.02135076252723	MGST1/MET/HMOX1/CCND1/MGST3/HGF	0.0531481603022816
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	3/324	82/9376	1.0587172538392	UGT2B7/MGST1/MGST3	0.101031592495695
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	5/324	142/9376	1.018953225526	SMURF1/UBE2D2/NEDD4L/ANAPC4/UBC	0.0430544690729227
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	3/324	83/9376	1.04596162427488	UBE2D2/L3MBTL4/OGT	0.0795687098688279
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	6/324	173/9376	1.00363947762792	FDPS/IL18/TMPRSS4/EIF2AK2/TNFSF10/MX1	0.00914078018565932
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/324	23/9376	1.25818572195384	GLUL	0.234534395531828
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/324	23/9376	1.25818572195384	FUT9	0.234534395531828
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/324	23/9376	1.25818572195384	FDPS	0.234534395531828
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/324	23/9376	1.25818572195384	LNPEP	0.234534395531828
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	2/324	54/9376	1.07178783721994	CGA/HLA-C	0.100087322345794
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	2/324	55/9376	1.05230078563412	SPTLC3/PSAP	0.0735942991966265
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	3/324	87/9376	0.997871434653044	FOS/AREG/CCND1	-0.00377353170352098
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	5/324	149/9376	0.971082939763029	AGPAT5/DGKH/RAPGEF3/DGKI/GNAS	-0.0673136103135154
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	4/324	119/9376	0.972715011930698	FOS/RPS6KA5/JAG1/ATF4	-0.0566693182161334
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/324	26/9376	1.11301044634378	PLA2G5	0.109165480179983
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/324	26/9376	1.11301044634378	SCARB1	0.109165480179983
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	4/324	120/9376	0.964609053497942	RPS6KA5/RPS6KA2/NTRK2/ATF4	-0.0738171032265876
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	2/324	59/9376	0.980958359489433	NT5E/NT5C2	-0.0277573620772377
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	2/324	59/9376	0.980958359489433	CDH1/CCND1	-0.0277573620772377
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/324	27/9376	1.07178783721994	ELOVL7	0.0706701547353978
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/324	28/9376	1.03350970017637	ELOVL7	0.0335951107039616
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/324	28/9376	1.03350970017637	ATP6V1A	0.0335951107039616
Organismal Systems	Digestive system	hsa04970	Salivary secretion	3/324	93/9376	0.933492632417364	FXYD2/GNAS/ATP1A1	-0.12194189174026
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	12/324	370/9376	0.938538538538539	CSH1/CSH2/KISS1/GABRP/CGA/CSHL1/RXFP1/GH2/CRH/APLNR/NR3C1/F2RL1	-0.228204205852806
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	5/324	157/9376	0.921601006526697	HLA-C/CAPN1/CCND1/GATA4/ZFP36L1	-0.187414969422558
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	2/324	62/9376	0.933492632417364	HSPA8/PRKAA2	-0.0993993071117455
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	8/324	250/9376	0.926024691358025	SMURF1/HSPA8/FGFR2/NEDD4L/PARD6B/HLA-C/RAB11FIP3/RNF103-CHMP3	-0.224286135800558
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/324	29/9376	0.997871434653044	GNGT1	-0.00217187954862118
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	3/324	95/9376	0.913840155945419	FOS/IL18/ATP6V1A	-0.159681716053965
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	2/324	63/9376	0.918675289045659	PLA2G5/PTGES3	-0.122527584597417
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	2/324	63/9376	0.918675289045659	GTF2H2/POLR2L	-0.122527584597417
Genetic Information Processing	Translation	hsa03010	Ribosome	7/324	222/9376	0.912468023579135	RPLP2/RPL35/RPL36/MRPS2/RPS4X/RPL11/RPS26	-0.249702930096158
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/324	30/9376	0.964609053497942	PLA2G5	-0.03673041094522
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	6/324	193/9376	0.899635386682019	GNGT1/GNG11/VAV2/GNAI1/CXCL14/GNAI2	-0.266534142200365
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	2/324	65/9376	0.890408357075024	KISS1/CGA	-0.16773427786694
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	3/324	98/9376	0.885865457294029	SCIN/FCGR2B/VAV2	-0.214876453547759
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/324	31/9376	0.933492632417364	UGT2B7	-0.0701692481474668
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	3/324	99/9376	0.876917321361766	IL1R1/F2RL1/GNAS	-0.232914555050666
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	3/324	99/9376	0.876917321361766	KRT19/KRT18/FCGR2B	-0.232914555050666
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/324	32/9376	0.904320987654321	GALE	-0.102567820837366
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/324	32/9376	0.904320987654321	GABARAPL1	-0.102567820837366
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	2/324	67/9376	0.863829003132486	ALDH3B1/PKM	-0.211619836093372
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	3/324	101/9376	0.85955262192886	GNAI1/GNAS/GNAI2	-0.268474618817984
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	3/324	101/9376	0.85955262192886	EGR1/CCND1/DIAPH1	-0.268474618817984
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	4/324	134/9376	0.863829003132486	MYL6/GNAS/PLA2G5/MYH14	-0.30035848463787
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/324	68/9376	0.851125635439361	UGT2B7/CYP3A5	-0.233094518406974
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/324	33/9376	0.876917321361766	BCKDHB	-0.133997472104893
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/324	33/9376	0.876917321361766	STX18	-0.133997472104893
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/324	34/9376	0.851125635439361	POLR2L	-0.164522506932986
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	5/324	169/9376	0.856161881802907	DAPK1/GABARAPL1/DEPTOR/PRKAA2/UBC	-0.356980212753275
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	2/324	71/9376	0.815162580420796	MET/ATP6V1A	-0.29576498209053
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/324	36/9376	0.803840877914952	UGT2B7	-0.223085936074349
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/324	36/9376	0.803840877914952	B3GNT3	-0.223085936074349
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/324	37/9376	0.782115448782115	GALE	-0.251225074290482
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	4/324	142/9376	0.815162580420796	FOS/FOSB/IL1R1/FCGR2B	-0.419879822243274
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	2/324	75/9376	0.771687242798354	PKM/GLUL	-0.375562186623176
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	2/324	75/9376	0.771687242798354	MGST1/MGST3	-0.375562186623176
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	2/324	75/9376	0.771687242798354	CCND1/SFN	-0.375562186623176
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1/324	38/9376	0.761533463287849	GALE	-0.278662275142482
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	3/324	110/9376	0.789225589225589	EPAS1/HMOX1/SLC2A1	-0.420682018629549
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/324	39/9376	0.742006964229186	HLA-C	-0.305437585263549
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	2/324	77/9376	0.751643418310085	MECOM/CCND1	-0.413988982229675
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	5/324	180/9376	0.803840877914952	CALR/HLA-C/EIF2AK2/ZC3HAV1/BST2	-0.502725773575516
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/324	41/9376	0.70581150255947	GABRP	-0.357146440428759
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	3/324	116/9376	0.748403575989783	GLDC/PCCA/PKM	-0.515838598734377
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	5/324	187/9376	0.773750577672146	TXNIP/GABARAPL1/IL18/HSP90AA1/HSP90AB1	-0.591234852451333
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	4/324	154/9376	0.751643418310085	UGT2B7/IDO2/DHFR/ALPP	-0.587907967408194
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	2/324	83/9376	0.697307749516585	IL18/POLR2L	-0.524020467906358
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/324	44/9376	0.657687991021324	PARP4	-0.430573184580856
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	9/324	323/9376	0.806329549363605	EZR/MET/RPS6KA5/HMOX1/MCL1/CCND1/ZFPM2/ST14/HNRNPK	-0.670122553530621
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/324	45/9376	0.643072702331962	ABCC3	-0.454054304016175
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/324	45/9376	0.643072702331962	HLA-C	-0.454054304016175
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	3/324	122/9376	0.711596842744384	CD36/CCND1/PRKAA2	-0.606598104472937
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	4/324	158/9376	0.732614471011095	YWHAZ/CCND1/ANAPC4/SFN	-0.641259720822125
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	1/324	47/9376	0.615707906488048	PKM	-0.499664738705844
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/324	47/9376	0.615707906488048	PKM	-0.499664738705844
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	3/324	125/9376	0.694518518518519	SPTLC3/GNAI1/GNAI2	-0.650476220720313
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	2/324	88/9376	0.657687991021324	C7/CLU	-0.610363055826382
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	1/324	49/9376	0.590576971529352	OGT	-0.543607185524372
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	2/324	90/9376	0.643072702331962	ATF4/PRKAA2	-0.643683756311396
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	1/324	51/9376	0.567417090292907	PLA2G5	-0.586024665969748
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	2/324	93/9376	0.622328421611576	FOS/JAG1	-0.692464435131815
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	5/324	205/9376	0.70581150255947	CALR/ISG15/HLA-C/EIF2AK2/CCND1	-0.805712576344795
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	3/324	133/9376	0.652742968532442	HLA-C/TNFSF10/VAV2	-0.763055738856879
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	1/324	54/9376	0.535893918609968	AMD1	-0.647061351471213
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	2/324	98/9376	0.590576971529352	DGKH/DGKI	-0.77080405522099
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	3/324	138/9376	0.629092860976919	RPS6KA2/YWHAZ/ANAPC4	-0.830427317917739
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	1/324	56/9376	0.516754850088183	RPN1	-0.686182174597714
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/324	57/9376	0.507688975525233	ELOVL7	-0.705307015708133
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	6/324	254/9376	0.68358121901429	MET/FGFR2/NTRK2/SLC8A1/GNAS/HGF	-0.967208151601169
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	3/324	144/9376	0.602880658436214	LPIN3/CCND1/PRKAA2	-0.908532062896354
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	1/324	62/9376	0.466746316208682	JAG1	-0.796980073189385
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	3/324	148/9376	0.586586586586587	FOS/CCND1/JAG1	-0.959063800158326
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	1/324	63/9376	0.45933764452283	MECOM	-0.81458700217897
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	2/324	108/9376	0.535893918609968	NUP214/EEF1A1	-0.917744932316924
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	1/324	66/9376	0.438458660680883	IL18	-0.866093404635585
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	1/324	69/9376	0.419395240651279	VAV2	-0.915769448297173
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	1/324	72/9376	0.401920438957476	ISG15	-0.96377627005556
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	3/324	163/9376	0.53260622585776	FOS/YWHAZ/ATF4	-1.13883828961392
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	2/324	122/9376	0.474397895162923	FOS/VAV2	-1.10549844022191
Human Diseases	Cancer: specific types	hsa05214	Glioma	1/324	76/9376	0.380766731643925	CCND1	-1.02542871156003
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	1/324	77/9376	0.375821709155042	CCND1	-1.04045132848297
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	5/324	250/9376	0.578765432098765	DEPTOR/PSAP/NAPSA/ATP6V1A/LAPTM5	-1.27714335005258
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	3/324	178/9376	0.487723678734915	GPC4/CCND1/PRICKLE2	-1.30542958626533
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	1/324	86/9376	0.33649153028998	AREG	-1.16942859838981
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/324	86/9376	0.33649153028998	SCNN1A	-1.16942859838981
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	3/324	181/9376	0.47963986085533	FCGR2B/IL18/NFYC	-1.33737534467875
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	1/324	90/9376	0.321536351165981	FOS	-1.22354337383404
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	2/324	144/9376	0.401920438957476	KCNC3/ATXN10	-1.36829008436204
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	1/324	103/9376	0.280954093251828	MSI2	-1.38819658431191
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	1/324	105/9376	0.275602586713698	IL1R1	-1.41219321481688
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	1/324	109/9376	0.265488730320535	FOS	-1.45924428705791
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	1/324	117/9376	0.247335654743062	CECR2	-1.54988010282241
Genetic Information Processing	Transcription	hsa03040	Spliceosome	3/324	243/9376	0.357262612406645	HSPA8/PRPF38B/HNRNPK	-1.92050676758707
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	1/324	138/9376	0.20969762032564	PRKAA2	-1.76941508115902
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	1/324	143/9376	0.202365535698869	C7	-1.81838727008915
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	1/324	183/9376	0.158132631720974	POP7	-2.17583752072545
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/324	449/9376	0.064450493552201	SLC8A1	-3.84346603713198