category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	9/117	122/9376	5.91172761664565	CSH1/CSHL1/CSH2/FOS/STAT5B/CREB3L2/GH2/PLCB1/SOS2	6.13826974463222
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	9/117	139/9376	5.18871057000553	EGFR/FOS/CREB3L2/BCL2/KRT10/KRT23/PLCB1/NCOA3/SOS2	5.59266502703209
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	9/117	168/9376	4.29304029304029	CSH1/EGFR/CSHL1/CSF3R/CSH2/STAT5B/GH2/BCL2/SOS2	4.8413397069413
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	5/117	52/9376	7.70545693622617	CYP19A1/CGA/HSD3B1/CYP11A1/HSD17B1	5.45036320622312
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	5/117	66/9376	6.07096607096607	CYP19A1/HSD3B1/CYP11A1/HSD17B1/STS	4.64712504948776
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	4/117	44/9376	7.28515928515929	MAN1C1/MAN1A2/TUSC3/STT3B	4.6973377563143
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	6/117	115/9376	4.18104793756968	EGFR/PDE4D/FOS/CREB3L2/BCL2/PLCB1	3.85821761018031
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	5/117	87/9376	4.60556046762943	EGFR/GADD45G/FOS/BCL2/SOS2	3.79790813133888
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	6/117	125/9376	3.8465641025641	SPTLC3/PRKCZ/BCL2/PLCB1/GAB2/PRKCE	3.60145639852927
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	4/117	56/9376	5.72405372405372	MAN1C1/MAN1A2/TUSC3/STT3B	3.98563397516715
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	3/117	29/9376	8.29000884173298	STK3/TEAD3/WWC1	4.41964574140312
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	6/117	130/9376	3.69861932938856	EGFR/FOS/CREB3L2/PRKCZ/PLCB1/SOS2	3.48283488150072
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	5/117	98/9376	4.08860980289552	HSD3B1/CYP11A1/CREB3L2/PLCB1/PRKCE	3.45497911373061
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	5/117	99/9376	4.04731071397738	EGFR/FOS/BCL2/NCOA3/SOS2	3.42631339903193
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	5/117	101/9376	3.96716594736397	STAT5B/PRKCZ/BCL2/PLCB1/PRKCE	3.37009459280144
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	6/117	142/9376	3.38605994944023	FOS/PRKCZ/BCL2/SDC1/DUSP1/SQSTM1	3.22052826553611
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	4/117	65/9376	4.93149243918475	HSD3B1/CYP11A1/CREB3L2/PLCB1	3.57529998283364
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	6/117	149/9376	3.22698330752022	EGFR/CYTH3/PLCB1/GAB2/SOS2/PIP5K1B	3.08018188718957
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	4/117	71/9376	4.51474659925364	CGA/FOS/STAT5B/SOS2	3.34165439764409
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	8/117	250/9376	2.56437606837607	EGFR/AGAP1/PRKCZ/CYTH3/SH3GLB2/RNF103-CHMP3/PIP5K1B/GRK5	2.8181717861478
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	4/117	73/9376	4.39105491160286	EGFR/GADD45G/STAT5B/SOS2	3.26949945272961
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	3/117	41/9376	5.86366479049406	EGFR/DAPK1/RPS6KA5	3.50828550777534
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	4/117	77/9376	4.16294816294816	GADD45G/STAT5B/GAB2/SOS2	3.13267859866289
NA	NA	hsa04081	Hormone signaling	7/117	219/9376	2.561448698435	CSH1/CGA/CSHL1/CSH2/STAT5B/GH2/PLCB1	2.6282683022712
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/117	21/9376	7.63207163207163	CSGALNACT1/CHSY1	3.42005812263378
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	4/117	93/9376	3.44674202738719	EGFR/CGA/PLCB1/SOS2	2.66552038331241
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	8/117	300/9376	2.13698005698006	RASA1/EGFR/GADD45G/FOS/STK3/RPS6KA5/DUSP1/SOS2	2.24989762808385
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	4/117	99/9376	3.2378485711819	EGFR/FOS/SOS2/PIP5K1B	2.51617615140966
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	9/117	362/9376	1.99235019124522	CSH1/EGFR/CSHL1/CSF3R/CSH2/CREB3L2/GH2/BCL2/SOS2	2.16449702458832
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	3/117	59/9376	4.07475010864841	EGFR/GADD45G/SOS2	2.66314191895569
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	5/117	148/9376	2.70732270732271	EGFR/GADD45G/FOS/NCOA3/SOS2	2.35336455600277
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	7/117	253/9376	2.21722239113543	EGFR/CYTH3/BCL2/RPS6KA5/PLCB1/PRKCE/SQSTM1	2.20626605398287
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	6/117	204/9376	2.35696329813977	EGFR/GPC3/EZR/ANK3/SDC1/SOS2	2.20266113608783
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	4/117	106/9376	3.02402838251895	EGFR/CREB3L2/BCL2/SOS2	2.3557336784219
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	5/117	155/9376	2.58505652054039	EGFR/HSD3B1/CYP11A1/CREB3L2/PLCB1	2.23675346177376
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	5/117	157/9376	2.55212586422778	STK3/PRKCZ/DLG5/TEAD3/WWC1	2.20460801347013
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	4/117	109/9376	2.94079824355054	CREB3L2/PRKCZ/SLC2A1/PRKCE	2.29097623933321
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	3/117	65/9376	3.69861932938856	CGA/KISS1/PLCB1	2.45412493888407
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	4/117	110/9376	2.91406371406371	EGFR/EPAS1/BCL2/SLC2A1	2.26988111622162
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	5/117	163/9376	2.45818258088197	FOS/STAT5B/CREB3L2/BCL2/SOS2	2.11106545735226
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	6/117	217/9376	2.21576273189176	EGFR/FOS/STAT5B/CREB3L2/BCL2/SOS2	2.03681315277541
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	4/117	115/9376	2.78736529171312	FOS/CREB3L2/BCL2/PLCB1	2.167852977903
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	3/117	70/9376	3.43443223443223	EPAS1/SLC2A1/SOS2	2.29806184857351
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	4/117	119/9376	2.69367234073116	FOS/CREB3L2/CEBPB/RPS6KA5	2.09008655233601
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	4/117	122/9376	2.62743449628696	MED12L/SLC2A1/PLCB1/NCOA3	2.03383263682508
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	5/117	174/9376	2.30278023381472	MAN1C1/MAN1A2/TUSC3/BCL2/STT3B	1.94984997568337
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	3/117	75/9376	3.20547008547009	GADD45G/BCL2/SIAH1	2.15557683611188
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	3/117	75/9376	3.20547008547009	CGA/CREB3L2/PLCB1	2.15557683611188
Human Diseases	Cancer: specific types	hsa05214	Glioma	3/117	76/9376	3.16329284750337	EGFR/GADD45G/SOS2	2.128517196634
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	6/117	232/9376	2.07250221043324	EGFR/EZR/DIAPH2/IQGAP2/SOS2/PIP5K1B	1.85939049566084
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	6/117	233/9376	2.063607351161	ANK3/FBN2/DIAPH2/NEBL/SDC1/SYNE2	1.84804038667468
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	3/117	78/9376	3.08218277449047	MTMR4/PLCB1/PIP5K1B	2.07571587481151
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	3/117	80/9376	3.0051282051282	EGFR/BCL2/SOS2	2.02458310807215
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	7/117	298/9376	1.8824069293868	CSH1/CSHL1/CSF3R/GDF15/CSH2/INHBA/GH2	1.74011711973057
NA	NA	hsa04517	IgSF CAM signaling	7/117	299/9376	1.87611125403768	GRIP1/RASA1/EZR/ANK3/NECTIN3/GLDN/NECTIN4	1.73069369904095
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	3/117	85/9376	2.82835595776772	UCK2/ADK/ENTPD1	1.90342386915469
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	3/117	86/9376	2.79546809779368	EGFR/STAT5B/SOS2	1.88024996192705
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	3/117	86/9376	2.79546809779368	CREB3L2/SLC2A1/PLCB1	1.88024996192705
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	5/117	193/9376	2.07608166157389	STAT5B/PRKCZ/PLCB1/SOS2/GRK5	1.6979625983393
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/117	42/9376	3.81603581603582	KYNU/KMO	2.05601106720162
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	3/117	89/9376	2.7012388360703	EGFR/PLCB1/SOS2	1.81267145537531
Human Diseases	Substance dependence	hsa05032	Morphine addiction	3/117	91/9376	2.64187094956326	PDE4D/GABRE/GRK5	1.76915257093799
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	3/117	93/9376	2.58505652054039	EGFR/NECTIN3/NECTIN4	1.72678623937907
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	3/117	93/9376	2.58505652054039	FOS/STAT5B/MAML2	1.72678623937907
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	2/117	47/9376	3.41007455901073	PRKCZ/PRKCE	1.86190872790331
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	4/117	150/9376	2.13698005698006	EGFR/GADD45G/BCL2/SOS2	1.57793198136439
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	3/117	97/9376	2.47845625165213	FOS/RPS6KA5/PLCB1	1.64528176679981
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	3/117	98/9376	2.45316588173731	MTMR4/PLCB1/PIP5K1B	1.62553967337718
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	3/117	98/9376	2.45316588173731	GAB2/PRKCE/PIP5K1B	1.62553967337718
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	4/117	154/9376	2.08147408147408	RDH13/KYNU/KMO/ALPP	1.52110937891246
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	4/117	154/9376	2.08147408147408	CREB3L2/BCL2/RPS6KA5/PLCB1	1.52110937891246
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/117	12/9376	6.67806267806268	NECTIN4	2.21236423859371
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	3/117	105/9376	2.28962148962149	GADD45G/TRIM25/BCL2	1.49379206248828
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	3/117	107/9376	2.24682482626408	CREB3L2/SLC2A1/PLCB1	1.45806678230265
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	2/117	55/9376	2.91406371406371	SPTLC3/ACER3	1.60030590579205
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	4/117	168/9376	1.90801790801791	STAT5B/BCL2/RNF103-CHMP3/SQSTM1	1.33494362701595
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	4/117	169/9376	1.8967278612249	BCL2/DAPK1/MTMR4/SQSTM1	1.32233493320404
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/117	14/9376	5.72405372405372	ST3GAL1	1.98834185422973
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	4/117	170/9376	1.88557063851181	EZR/PRKCZ/PRKCE/ARHGAP17	1.30981123504927
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	2/117	59/9376	2.71650007243228	UCK2/ENTPD1	1.48671701284834
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/117	15/9376	5.34245014245014	ST3GAL1	1.89197709671399
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/117	15/9376	5.34245014245014	ALPP	1.89197709671399
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	3/117	116/9376	2.07250221043324	SHANK2/PLCB1/SLC38A1	1.3065265041586
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	5/117	238/9376	1.68354521295698	RASA1/EGFR/RASAL2/GAB2/SOS2	1.20067833653784
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	7/117	370/9376	1.51610071610072	CSH1/CGA/CSHL1/KISS1/CSH2/GH2/GABRE	1.13858610477259
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/117	16/9376	5.00854700854701	ST3GAL1	1.80387140822265
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	3/117	120/9376	2.0034188034188	BCL2/RPS6KA5/SOS2	1.24353413812903
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	4/117	184/9376	1.7421033073207	RASA1/SEMA3B/PRKCZ/SEMA6A	1.14278570131733
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	2/117	68/9376	2.35696329813977	STAT5B/SOS2	1.26238230257087
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	2/117	69/9376	2.32280440976093	GAB2/SOS2	1.23968643616257
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	2/117	69/9376	2.32280440976093	FOS/CREB3L2	1.23968643616257
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	3/117	128/9376	1.87820512820513	PDE4D/ADK/ENTPD1	1.12453653589005
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	6/117	323/9376	1.48860839882512	EGFR/EZR/BCL2/RPS6KA5/PRKCE/SOS2	1.00452894655231
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	2/117	71/9376	2.25737329962682	EGFR/SLC2A1	1.19545090877119
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	3/117	133/9376	1.80759591285907	EGFR/GADD45G/SOS2	1.05441113441964
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	3/117	133/9376	1.80759591285907	FOS/CREB3L2/PLCB1	1.05441113441964
Human Diseases	Cancer: specific types	hsa05218	Melanoma	2/117	73/9376	2.19552745580143	EGFR/GADD45G	1.15267268279605
NA	NA	hsa04519	Cadherin signaling	7/117	404/9376	1.38850808157739	EGFR/STK3/GABRE/KRT10/KRT23/TEAD3/WWC1	0.897310261620075
Human Diseases	Infectious disease: viral	hsa05162	Measles	3/117	136/9376	1.76772247360483	FOS/STAT5B/BCL2	1.01375789517809
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	3/117	137/9376	1.75481938985589	GADD45G/FOS/BCL2	1.00043153967491
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	2/117	76/9376	2.10886189833558	EZR/PLCB1	1.09103657510975
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	4/117	203/9376	1.57904930318723	EGFR/BCL2/SOS2/PIP5K1B	0.937571489700261
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	2/117	77/9376	2.08147408147408	EGFR/GADD45G	1.07112432310133
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/117	23/9376	3.4842066146414	LNPEP	1.34082683021935
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	3/117	142/9376	1.69302997472012	FOS/GAB2/SQSTM1	0.935400899283154
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	2/117	83/9376	1.93100607558439	RYBP/AUTS2	0.957657291661306
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/117	26/9376	3.08218277449047	SLC5A6	1.19507798150378
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/117	28/9376	2.86202686202686	ST3GAL4	1.10918026227368
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/117	28/9376	2.86202686202686	ALPP	1.10918026227368
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	3/117	154/9376	1.56110556110556	EGFR/FOS/PLCB1	0.789203316268346
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	2/117	89/9376	1.80082589071353	GABRE/SLC38A1	0.853280681138848
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	4/117	224/9376	1.43101343101343	FOS/STAT5B/CREB3L2/SLC2A1	0.733927792749176
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	2/117	90/9376	1.78081671415005	EGFR/FOS	0.836666814190741
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	4/117	226/9376	1.41834959534075	CGA/PDE4D/FOS/CREB3L2	0.715615193728739
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	3/117	157/9376	1.53127551853666	GULP1/CEBPB/SLC2A1	0.754612942494301
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	2/117	91/9376	1.76124729970884	FOS/SOS2	0.820260945452345
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	4/117	227/9376	1.41210135923792	EGFR/CREB3L2/PLCB1/SOS2	0.706523625423275
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/117	31/9376	2.58505652054039	ACSS1	0.993647797319001
Organismal Systems	Digestive system	hsa04970	Salivary secretion	2/117	93/9376	1.72337101369359	TRPV6/PLCB1	0.788052095445741
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	2/117	93/9376	1.72337101369359	GADD45G/BCL2	0.788052095445741
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	2/117	94/9376	1.70503727950536	FOS/CEBPB	0.772239039668798
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/117	32/9376	2.5042735042735	ACSS1	0.95814647762483
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/117	32/9376	2.5042735042735	BCL2	0.95814647762483
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	3/117	166/9376	1.44825455668829	CREB3L2/PLCB1/PRKCE	0.655006287671622
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/117	34/9376	2.35696329813977	NPAS2	0.891013235944808
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	2/117	99/9376	1.61892428559095	PLCB1/PRKCE	0.69590165616511
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	2/117	99/9376	1.61892428559095	KRT10/KRT23	0.69590165616511
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	3/117	170/9376	1.41417797888386	EGFR/GADD45G/SOS2	0.612593672892919
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	2/117	101/9376	1.58686637894559	CREB3L2/PLCB1	0.666560362806319
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/117	36/9376	2.22602089268756	ST3GAL1	0.828461270219553
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	2/117	103/9376	1.55605343954858	FOS/PLCB1	0.637854378378473
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/117	37/9376	2.16585816585817	PLCB1	0.798716985589187
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	1/117	37/9376	2.16585816585817	GADD45G	0.798716985589187
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	4/117	248/9376	1.2925282602702	FOS/CYTH3/BCL2/SNX9	0.524810336346915
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	2/117	105/9376	1.52641432641433	SIAH1/SQSTM1	0.609755303169329
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	2/117	109/9376	1.47039912177527	FOS/STAT5B	0.555273179255785
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	5/117	333/9376	1.20325453658787	EGFR/CREB3L2/PRKCZ/MAML2/SOS2	0.424524369918818
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/117	41/9376	1.95455493016469	GABRE	0.688544826201332
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	1/117	42/9376	1.90801790801791	SAT1	0.662951393398874
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	3/117	187/9376	1.28561634443987	BCL2/NEK7/PLCB1	0.443472057621823
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/117	43/9376	1.86364539852912	ACADVL	0.638051281632156
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	2/117	115/9376	1.39368264585656	PLCB1/DUSP1	0.477488345625689
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	1/117	44/9376	1.82128982128982	CREB3L2	0.613807146547684
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	1/117	47/9376	1.70503727950536	ACSS1	0.544678196489936
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	2/117	122/9376	1.31371724814348	CREB3L2/TBC1D1	0.392057793702226
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	2/117	122/9376	1.31371724814348	FOS/SOS2	0.392057793702226
NA	NA	hsa03272	Virion - Hepatitis viruses	1/117	48/9376	1.66951566951567	EGFR	0.522737459432633
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/117	48/9376	1.66951566951567	PLCB1	0.522737459432633
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	3/117	200/9376	1.20205128205128	EZR/FOS/CYTH3	0.324673193574916
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/117	49/9376	1.63544392115821	CREB3L2	0.50130358235218
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	3/117	201/9376	1.19607092741421	AFF1/GADD45G/CEBPB	0.315867339424785
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/117	50/9376	1.60273504273504	SAT1	0.480352732470294
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	1/117	50/9376	1.60273504273504	SDC1	0.480352732470294
Organismal Systems	Immune system	hsa04611	Platelet activation	2/117	126/9376	1.27201193867861	PRKCZ/PLCB1	0.345540453557327
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	3/117	205/9376	1.17273295809881	GADD45G/BCL2/ENTPD1	0.281086715835643
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	3/117	205/9376	1.17273295809881	PRKCZ/SLC2A1/PLCB1	0.281086715835643
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	1/117	52/9376	1.54109138724523	MYLIP	0.439812620719838
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	1/117	53/9376	1.51201419125947	PLCB1	0.42018313593498
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	1/117	54/9376	1.48401392845837	CGA	0.400956000368313
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	3/117	212/9376	1.13401064344461	EGFR/PRKCZ/PLCB1	0.221850907547226
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	2/117	134/9376	1.19607092741421	PLCB1/PRKCE	0.256968060814682
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	1/117	56/9376	1.43101343101343	BCL2	0.363641455992247
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	3/117	216/9376	1.11301044634378	FOS/BCL2/PLCB1	0.188883601935257
NA	NA	hsa04382	Cornified envelope formation	3/117	217/9376	1.10788136594588	SPTLC3/KRT10/KRT23	0.180737720719599
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/117	57/9376	1.40590793222372	ACADVL	0.345522900974013
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	2/117	138/9376	1.16140220488047	PRKCZ/SOS2	0.214712117259488
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	2/117	138/9376	1.16140220488047	FOS/PIP5K1B	0.214712117259488
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	2/117	140/9376	1.14481074481074	PLCB1/PRKCE	0.194052557118368
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1/117	59/9376	1.35825003621614	CGA	0.310292106740985
Organismal Systems	Nervous system	hsa04730	Long-term depression	1/117	60/9376	1.33561253561254	PLCB1	0.293153839271922
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	2/117	142/9376	1.12868664981341	RHOBTB1/SIAH1	0.173691777198835
Organismal Systems	Digestive system	hsa04978	Mineral absorption	1/117	61/9376	1.31371724814348	TRPV6	0.276317513234652
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	2/117	144/9376	1.11301044634378	INHBA/TBX3	0.153620249232887
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	3/117	227/9376	1.05907601942844	EGFR/FOS/SOS2	0.101282372616639
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	1/117	62/9376	1.2925282602702	MAML2	0.259771847628734
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	1/117	63/9376	1.27201193867861	KMT2C	0.243506167821097
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	1/117	63/9376	1.27201193867861	GADD45G	0.243506167821097
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	2/117	149/9376	1.07566110250674	GABRE/PLCB1	0.104648273168046
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	1/117	67/9376	1.19607092741421	ACSS1	0.181048785674883
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	1/117	67/9376	1.19607092741421	PLCB1	0.181048785674883
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/117	68/9376	1.17848164906988	RDH13	0.166041392149929
Organismal Systems	Endocrine system	hsa04924	Renin secretion	1/117	69/9376	1.16140220488047	PLCB1	0.151260551205153
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	2/117	156/9376	1.02739425816349	EGFR/SOS2	0.0387840278412516
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	1/117	70/9376	1.14481074481074	SLC2A1	0.136698834005827
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	2/117	157/9376	1.02085034569111	GADD45G/SQSTM1	0.0296154070063856
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	2/117	158/9376	1.01438926755382	CLIP1/SOS2	0.0205043216763442
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	1/117	71/9376	1.12868664981341	EGFR	0.122349164334744
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	1/117	72/9376	1.11301044634378	TRIM25	0.10820479699647
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	2/117	160/9376	1.0017094017094	NECTIN3/SDC1	0.00245148601027173
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	1/117	73/9376	1.09776372790071	SERINC5	0.0942592978292726
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	1/117	75/9376	1.06849002849003	BCL2	0.066940612747545
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	1/117	76/9376	1.05443094916779	PLIN2	0.0535559535855093
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	1/117	78/9376	1.02739425816349	DCP2	0.0273091763342215
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	1/117	78/9376	1.02739425816349	FOS	0.0273091763342215
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	1/117	78/9376	1.02739425816349	FOS	0.0273091763342215
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1/117	82/9376	0.977277465082343	UCK2	-0.0232305182515336
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	2/117	178/9376	0.900412945356766	SIAH1/PLCB1	-0.150786587810843
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	2/117	180/9376	0.890408357075024	SRSF5/BCL2	-0.166882476478763
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/117	86/9376	0.93182269926456	PLCB1	-0.0713966275811997
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	2/117	181/9376	0.885488973886764	CEBPB/BCL2	-0.174866756239226
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	1/117	89/9376	0.900412945356766	SDC1	-0.106110093097612
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	1/117	90/9376	0.890408357075024	CREB3L2	-0.117430491799576
Organismal Systems	Digestive system	hsa04976	Bile secretion	1/117	90/9376	0.890408357075024	SLC2A1	-0.117430491799576
Human Diseases	Substance dependence	hsa05034	Alcoholism	2/117	191/9376	0.839128294625677	CREB3L2/SOS2	-0.252495298587282
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	1/117	95/9376	0.843544759334233	FOS	-0.172286424587245
Cellular Processes	Cell motility	hsa04814	Motor proteins	2/117	194/9376	0.826152083884043	MYO9A/KIF2A	-0.27504150579045
NA	NA	hsa04082	Neuroactive ligand signaling	2/117	199/9376	0.805394493836705	GABRE/PLCB1	-0.311908940448501
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	1/117	100/9376	0.801367521367521	CSF3R	-0.224474193050126
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	1/117	102/9376	0.785654432713256	PLCB1	-0.244668226385693
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	1/117	103/9376	0.778026719774292	PLCB1	-0.254627736481483
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	2/117	205/9376	0.781821972065874	STAT5B/CREB3L2	-0.355039049956051
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	1/117	104/9376	0.770545693622617	GDPD5	-0.264498186139801
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	1/117	109/9376	0.735199560887634	FOS	-0.312578350782928
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	1/117	110/9376	0.728515928515929	INHBA	-0.321951961519783
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	2/117	214/9376	0.748941608754693	FOS/BCL2	-0.417621656392731
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	1/117	112/9376	0.715506715506715	BCL2	-0.340469556044069
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	1/117	116/9376	0.690834070144415	ACSS1	-0.37662717858268
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	1/117	116/9376	0.690834070144415	EZR	-0.37662717858268
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	2/117	235/9376	0.682014911802146	CREB3L2/SOS2	-0.55493275267866
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	2/117	238/9376	0.673418085182791	EGFR/FOS	-0.573656025663293
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	1/117	133/9376	0.602531970953024	SOS2	-0.518941104988104
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	2/117	254/9376	0.630998048320883	EGFR/PLCB1	-0.67018856668272
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	1/117	144/9376	0.55650522317189	ACADVL	-0.602862658754271
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	1/117	144/9376	0.55650522317189	PLCB1	-0.602862658754271
NA	NA	hsa04518	Integrin signaling	1/117	154/9376	0.52036852036852	EGFR	-0.674608809019886
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	1/117	155/9376	0.517011304108078	COLEC12	-0.681569788543271
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	1/117	157/9376	0.510425172845555	FOS	-0.69538212848153
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	1/117	158/9376	0.507194633776912	GADD45G	-0.702234475456752
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	1/117	173/9376	0.463218220443654	TRIM25	-0.801037104567015
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	2/117	308/9376	0.52036852036852	CREB3L2/PLCB1	-0.962107962529034
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	1/117	195/9376	0.410957703265396	PLCB1	-0.934362327524862
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	1/117	196/9376	0.408860980289552	FOS	-0.940140688877105
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	3/117	480/9376	0.500854700854701	BCL2/PLCB1/SQSTM1	-1.26196335485035
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	2/117	368/9376	0.435525826830175	BCL2/SQSTM1	-1.24179619191326
Genetic Information Processing	Transcription	hsa03040	Spliceosome	1/117	243/9376	0.32978087299075	SRSF5	-1.18989804988553
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	2/117	388/9376	0.413076041942021	PLCB1/BACE2	-1.32728044399151
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	1/117	268/9376	0.299017731853553	DUSP1	-1.30875828926157
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	1/117	275/9376	0.291406371406371	CREB3L2	-1.34065045451658