category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	11/92	70/9376	16.0149068322981	HLA-DQA1/HLA-DPB1/HLA-DQB1/HLA-DMB/HLA-DPA1/HLA-DRB1/CD55/HLA-DRA/HLA-DQA2/FYN/CD80	12.5516876609123
Human Diseases	Immune disease	hsa05330	Allograft rejection	9/92	39/9376	23.5183946488294	HLA-DQA1/HLA-DPB1/HLA-DQB1/HLA-DMB/HLA-DPA1/HLA-DRB1/HLA-DRA/HLA-DQA2/CD80	14.027427612411
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	9/92	44/9376	20.8458498023715	HLA-DQA1/HLA-DPB1/HLA-DQB1/HLA-DMB/HLA-DPA1/HLA-DRB1/HLA-DRA/HLA-DQA2/CD80	13.1347151680496
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	9/92	45/9376	20.3826086956522	HLA-DQA1/HLA-DPB1/HLA-DQB1/HLA-DMB/HLA-DPA1/HLA-DRB1/HLA-DRA/HLA-DQA2/CD80	12.9737754316895
Human Diseases	Immune disease	hsa05310	Asthma	8/92	32/9376	25.4782608695652	HLA-DQA1/HLA-DPB1/HLA-DQB1/HLA-DMB/HLA-DPA1/HLA-DRB1/HLA-DRA/HLA-DQA2	13.8070570422064
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	9/92	50/9376	18.344347826087	HLA-DQA1/HLA-DPB1/HLA-DQB1/HLA-DMB/HLA-DPA1/HLA-DRB1/HLA-DRA/HLA-DQA2/CD80	12.240728262459
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	9/92	54/9376	16.9855072463768	HLA-DQA1/HLA-DPB1/HLA-DQB1/HLA-DMB/HLA-DPA1/HLA-DRB1/HLA-DRA/HLA-DQA2/CD80	11.7268329411597
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	11/92	100/9376	11.2104347826087	HLA-DQA1/HLA-DPB1/HLA-DQB1/HLA-DMB/HLA-DPA1/HLA-DRB1/CD55/IL4R/CSF2RA/HLA-DRA/HLA-DQA2	10.2182341830094
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	13/92	160/9376	8.2804347826087	HLA-DQA1/HLA-DPB1/HLA-DQB1/HLA-DMB/NEGR1/HLA-DPA1/HLA-DRB1/CDH2/CD226/HLA-DRA/HLA-DQA2/CD58/CD80	9.24608880031198
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	10/92	82/9376	12.4284199363733	HLA-DQA1/HLA-DPB1/HLA-DQB1/CD74/HLA-DMB/HLA-DPA1/CIITA/HLA-DRB1/HLA-DRA/HLA-DQA2	10.3467455331177
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	9/92	66/9376	13.897233201581	HLA-DQA1/HLA-DPB1/HLA-DQB1/HLA-DMB/HLA-DPA1/HLA-DRB1/IL4R/HLA-DRA/HLA-DQA2	10.4666009335272
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	10/92	93/9376	10.958391771856	FOS/HLA-DQA1/HLA-DPB1/HLA-DQB1/HLA-DMB/HLA-DPA1/HLA-DRB1/IL4R/HLA-DRA/HLA-DQA2	9.60723674404471
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	10/92	95/9376	10.7276887871854	FOS/HLA-DQA1/HLA-DPB1/HLA-DQB1/HLA-DMB/HLA-DPA1/HLA-DRB1/HLA-DRA/HLA-DQA2/CD80	9.48606443441498
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	9/92	78/9376	11.7591973244147	FOS/HLA-DQA1/HLA-DPB1/HLA-DQB1/HLA-DMB/HLA-DPA1/HLA-DRB1/HLA-DRA/HLA-DQA2	9.49826733625208
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	10/92	109/9376	9.34982050259274	FOS/HLA-DQA1/HLA-DPB1/HLA-DQB1/HLA-DMB/HLA-DPA1/HLA-DRB1/IL4R/HLA-DRA/HLA-DQA2	8.72836286518218
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	12/92	173/9376	7.06911284242272	HLA-DQA1/HLA-DPB1/HLA-DQB1/HLA-DMB/CCND3/HLA-DPA1/CIITA/HLA-DRB1/HLA-DRA/PIK3CB/HLA-DQA2/MX2	8.02039096148491
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	10/92	112/9376	9.09937888198758	HLA-DQA1/HLA-DPB1/HLA-DQB1/HLA-DMB/HLA-DPA1/CIITA/GNAO1/HLA-DRB1/HLA-DRA/HLA-DQA2	8.5836784336021
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	11/92	181/9376	6.19361037713188	HLA-DQA1/HLA-DPB1/CAMK2D/HLA-DQB1/CD74/HLA-DMB/HLA-DPA1/CIITA/HLA-DRB1/HLA-DRA/HLA-DQA2	7.02335745578532
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	12/92	224/9376	5.45962732919255	FOS/HLA-DQA1/HLA-DPB1/HLA-DQB1/HLA-DMB/CCND3/HLA-DPA1/HLA-DRB1/HLA-DRA/VAC14/PIK3CB/HLA-DQA2	6.72475641105986
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	12/92	227/9376	5.38747366404903	FOS/MT-CO1/MT-ND3/PTK2/MT-CO3/MT-CYB/MT-CO2/MT-ATP6/MGST1/PIK3CB/MT-ND2/PTPRJ	6.66120230093634
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	11/92	205/9376	5.46850477200424	HLA-DQA1/HLA-DPB1/HLA-DQB1/HLA-DMB/CCND3/HLA-DPA1/HLA-DRB1/HLA-DRA/PIK3CB/HLA-DQA2/CD58	6.43936133938766
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	8/92	99/9376	8.23539745278876	HLA-DQA1/HLA-DPB1/HLA-DQB1/HLA-DMB/HLA-DPA1/HLA-DRB1/HLA-DRA/HLA-DQA2	7.20424041936177
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	10/92	180/9376	5.66183574879227	HLA-DQA1/HLA-DPB1/HLA-DQB1/CD74/HLA-DMB/HLA-DPA1/HLA-DRB1/HLA-DRA/PIK3CB/HLA-DQA2	6.28645375524748
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	9/92	143/9376	6.41410763149894	HLA-DQA1/HLA-DPB1/HLA-DQB1/HLA-DMB/HLA-DPA1/HLA-DRB1/HLA-DRA/HLA-DQA2/CD80	6.49434673704667
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	9/92	155/9376	5.91753155680224	HLA-DQA1/HLA-DPB1/HLA-DQB1/HLA-DMB/HLA-DPA1/HLA-DRB1/HLA-DRA/HLA-DQA2/RAB7B	6.14519940187435
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	10/92	205/9376	4.97136797454931	CAMK2D/MT-CO1/MT-ND3/MT-CO3/MT-CYB/PLCB2/MT-CO2/MT-ATP6/PIK3CB/MT-ND2	5.72295985001823
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	7/92	115/9376	6.20340264650284	FOS/CAMK2D/GNAO1/PLCB2/GNAQ/PIK3CB/FYN	5.58881067159943
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	6/92	91/9376	6.71954132823698	FOS/CARD11/VAV3/INPP5D/BANK1/PIK3CB	5.45761543812493
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	10/92	268/9376	3.80272550292018	CAMK2D/MT-CO1/MT-ND3/MT-CO3/LRRK2/MT-CYB/MT-CO2/DUSP1/MT-ATP6/MT-ND2	4.63391899162557
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	7/92	138/9376	5.16950220541903	MT-CO1/MT-ND3/MT-CO3/MT-CYB/MT-CO2/MT-ATP6/MT-ND2	4.91186880208872
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	5/92	65/9376	7.83946488294314	PLCB2/GNAQ/PIK3CB/KISS1/ARRB1	5.50798342904181
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	6/92	103/9376	5.93668214436471	PTK2/SERPINB6/PLCB2/GNAQ/PIK3CB/RAB7B	5.01482328658441
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	8/92	193/9376	4.22437485920252	PTK2/VAV3/HCK/PLCB2/GNAQ/XCR1/PIK3CB/ARRB1	4.50550913513385
NA	NA	hsa04517	IgSF CAM signaling	10/92	299/9376	3.40846299258398	PTK2/VAV3/INPP5D/MBP/CDH2/CD226/PAK3/PIK3CB/FYN/CD80	4.21324185553026
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	7/92	157/9376	4.54389365826641	CAMK2D/PTK2/AXL/NR1H2/ABCA1/HAVCR2/RAB7B	4.45759478050252
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	8/92	214/9376	3.80983340105648	FOS/PTK2/GNAO1/GNAQ/PAK3/PIK3CB/TRIM5/SAMHD1	4.1390845667408
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	6/92	122/9376	5.01211689237349	FOS/CARD11/VAV3/PAK3/PIK3CB/FYN	4.4401815854929
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	6/92	122/9376	5.01211689237349	FOS/CSH1/PTK2/PLCB2/GNAQ/PIK3CB	4.4401815854929
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	11/92	388/9376	2.88928731510533	MT-CO1/MT-ND3/MT-CO3/APOE/MT-CYB/PLCB2/MT-CO2/MT-ATP6/GNAQ/PIK3CB/MT-ND2	3.78350511626658
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	9/92	275/9376	3.33533596837945	MT-CO1/MT-ND3/MT-CO3/MT-CYB/MT-CO2/MT-ATP6/PIK3CB/MT-ND2/FYN	3.91275940488374
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	5/92	87/9376	5.85707146426787	MT-CO1/MT-CO3/SLC8A1/MT-CYB/MT-CO2	4.53066158823804
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	6/92	133/9376	4.59758090879372	FOS/CAMK2D/GNAO1/PLCB2/GNAQ/ARRB1	4.15950738641756
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	8/92	235/9376	3.46938020351526	MT-CO1/MT-ND3/MT-CO3/MT-CYB/ZNF516/MT-CO2/MT-ATP6/MT-ND2	3.81625182350286
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	6/92	139/9376	4.39912417891774	FOS/GNAO1/PLCB2/GNAQ/FKBP5/PIK3CB	4.0190271968726
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	5/92	97/9376	5.25324966382788	FOS/CAMK2D/GNAO1/PLCB2/GNAQ	4.19148717934114
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	5/92	98/9376	5.19964507542147	VAV3/INPP5D/HCK/PIK3CB/PRKCE	4.16016377626451
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	5/92	99/9376	5.14712340799297	CAMK2D/PLCB2/GNAQ/PIK3CB/PRKCE	4.12926508528274
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	9/92	308/9376	2.97797854319593	MT-CO1/MT-ND3/MT-CO3/MT-CYB/PLCB2/MT-CO2/MT-ATP6/GNAQ/MT-ND2	3.51360684605028
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	5/92	103/9376	4.94723512030393	FOS/GNAO1/PLCB2/GNAQ/PIK3CB	4.00971462615227
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	6/92	157/9376	3.89476599279978	FOS/MT-CO1/MT-CO3/MT-CYB/MT-CO2/PIK3CB	3.64110637185222
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	4/92	69/9376	5.90800252047889	VAV3/INPP5D/PIK3CB/FYN	4.07320671887359
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	7/92	216/9376	3.30273752012882	FOS/CAMK2D/PTK2/VAV3/PLCB2/ABCA1/PIK3CB	3.40828232226156
NA	NA	hsa04081	Hormone signaling	7/92	219/9376	3.25749454040103	CSH1/GNAO1/PLCB2/FSHR/GNAQ/THRB/PIK3CB	3.36499284394284
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	11/92	480/9376	2.33550724637681	CAMK2D/MT-CO1/MT-ND3/MT-CO3/LRRK2/MT-CYB/PLCB2/MT-CO2/MT-ATP6/GNAQ/MT-ND2	2.99007076238193
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	5/92	125/9376	4.07652173913043	PLCB2/GNAQ/PIK3CB/FYN/PRKCE	3.44693139966013
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	5/92	130/9376	3.91973244147157	FOS/GNAO1/PLCB2/PIK3CB/ARRB1	3.33695056564788
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	4/92	86/9376	4.74014155712841	CAMK2D/PTK2/PAK3/PIK3CB	3.46849756801351
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	5/92	138/9376	3.69250157529931	FOS/PTK2/VAV3/GNAQ/PIK3CB	3.17189291088486
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	5/92	142/9376	3.58848744641764	FOS/PTK2/DUSP1/MGST1/PIK3CB	3.09390722148708
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	6/92	203/9376	3.01220818162347	PTK2/CCND3/VAV3/PAK3/PIK3CB/FYN	2.88520860437738
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	3/92	53/9376	5.76866283839212	SLC8A1/PLCB2/GNAQ	3.4655222857268
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	5/92	149/9376	3.4199007878611	MT-ND3/GNAO1/PLCB2/GNAQ/MT-ND2	2.96396056297635
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	4/92	98/9376	4.15971606033718	CAMK2D/PLCB2/GNAQ/PRKCE	3.13001124176588
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	4/92	101/9376	4.03616013775291	CAMK2D/GNAO1/PLCB2/GNAQ	3.05379857265412
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	5/92	154/9376	3.30886504799548	FOS/CAMK2D/GNAO1/PLCB2/GNAQ	2.8757977316862
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	6/92	212/9376	2.88433141919606	VAV3/GNAO1/PLCB2/GNAQ/EVL/PIK3CB	2.76245152451713
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	6/92	217/9376	2.81787216990583	FOS/CCND3/BCL6/MGST1/PIK3CB/ARRB1	2.69700135351089
Organismal Systems	Nervous system	hsa04730	Long-term depression	3/92	60/9376	5.09565217391304	GNAO1/PLCB2/GNAQ	3.16807852795251
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	5/92	168/9376	3.03312629399586	CSH1/CCND3/IL4R/CSF2RA/PIK3CB	2.646965790934
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	4/92	115/9376	3.54480151228733	GNAO1/PLCB2/DUSP1/GNAQ	2.7332910434161
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	4/92	115/9376	3.54480151228733	FOS/PLCB2/GNAQ/ARRB1	2.7332910434161
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	3/92	67/9376	4.56327060350422	CAMK2D/PLCB2/GNAQ	2.91371236617469
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	3/92	69/9376	4.43100189035917	FOS/CAMK2D/FOSB	2.84742721585142
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	5/92	184/9376	2.76937618147448	CAMK2D/PTK2/PAK3/PIK3CB/FYN	2.41288190406623
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	3/92	73/9376	4.1882072662299	TRIM5/MX2/SAMHD1	2.722127436198
Organismal Systems	Immune system	hsa04611	Platelet activation	4/92	126/9376	3.23533471359558	PLCB2/GNAQ/PIK3CB/FYN	2.51460025181927
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	3/92	76/9376	4.02288329519451	CAMK2D/PLCB2/GNAQ	2.63389639871741
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	3/92	78/9376	3.91973244147157	INPP5D/PLCB2/PIK3CB	2.57755280837677
Human Diseases	Infectious disease: viral	hsa05162	Measles	4/92	136/9376	2.99744245524297	FOS/CCND3/PIK3CB/MX2	2.33571436130546
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	4/92	140/9376	2.91180124223603	SLC8A1/PLCB2/GNAQ/PRKCE	2.26869848567447
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	4/92	142/9376	2.87078995713411	FOS/FOSB/PIK3CB/FYN	2.2360744172328
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	2/92	37/9376	5.50881316098707	PLCB2/GNAQ	2.73542555209849
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	3/92	86/9376	3.55510616784631	CAMK2D/PLCB2/GNAQ	2.36953050942691
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	3/92	93/9376	3.2875175315568	CAMK2D/PLCB2/GNAQ	2.20685457906252
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	4/92	154/9376	2.64709203839639	CAMK2D/SLC8A1/PLCB2/GNAQ	2.05152897611363
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	7/92	368/9376	1.93856332703214	MT-CO1/MT-ND3/MT-CO3/MT-CYB/MT-CO2/MT-ATP6/MT-ND2	1.82845925628287
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	5/92	226/9376	2.25471335128896	FOS/CAMK2D/VAV3/FSHR/PIK3CB	1.90064136910135
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	3/92	98/9376	3.11978704525288	INPP5D/PLCB2/PIK3CB	2.09985870726725
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	5/92	227/9376	2.24478069335376	PTK2/GNAO1/PLCB2/GNAQ/PIK3CB	1.88986570715438
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	3/92	99/9376	3.08827404479578	FOS/PTK2/PIK3CB	2.07928152923006
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	3/92	101/9376	3.02712010331468	PLCB2/PIK3CB/PRKCE	2.03889656580579
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	2/92	47/9376	4.33672525439408	PIK3CB/PRKCE	2.28277872715418
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	4/92	166/9376	2.45573598742797	SLC8A1/PLCB2/GNAQ/PRKCE	1.88373077616269
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/92	48/9376	4.2463768115942	PLCB2/PIK3CB	2.24459123948523
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	3/92	107/9376	2.85737505079236	CAMK2D/PLCB2/GNAQ	1.92347719371538
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	3/92	109/9376	2.80494615077782	FOS/PIK3CB/CD80	1.88677408708495
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	3/92	109/9376	2.80494615077782	NR1H2/PIK3CB/PRKCE	1.88677408708495
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	2/92	52/9376	3.91973244147157	APOE/ABCA1	2.10162671680033
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	5/92	248/9376	2.054698457223	FOS/PAK3/PIK3CB/SNX9/RAB7B	1.67563074922276
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	3/92	116/9376	2.63568215892054	PTK2/VAV3/PIK3CB	1.76455176724393
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	3/92	116/9376	2.63568215892054	GNAO1/PLCB2/GNAQ	1.76455176724393
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	2/92	60/9376	3.39710144927536	PTK2/PIK3CB	1.85421156590002
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	3/92	122/9376	2.50605844618674	PLCB2/THRB/PIK3CB	1.66674430452061
NA	NA	hsa04082	Neuroactive ligand signaling	4/92	199/9376	2.04850338649771	GNAO1/PLCB2/P2RY14/GNAQ	1.48818867695876
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	4/92	200/9376	2.03826086956522	FOS/MYO1F/PAK3/FYN	1.47742950485732
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	2/92	65/9376	3.13578595317726	PLCB2/GNAQ	1.71999912850176
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	4/92	201/9376	2.0281202682241	PTK2/BCL6/ID2/REL	1.46673244547894
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	4/92	204/9376	1.99829497016198	CAMK2D/PTK2/VAV3/PIK3CB	1.43500670277513
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	4/92	205/9376	1.98854718981972	CCND3/REL/VAC14/PIK3CB	1.4245509138016
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	3/92	133/9376	2.29879045439686	VAV3/PIK3CB/FYN	1.50165586971712
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	3/92	134/9376	2.28163530175211	PLCB2/GNAQ/PRKCE	1.48746194738738
Organismal Systems	Endocrine system	hsa04924	Renin secretion	2/92	69/9376	2.95400126023945	PLCB2/GNAQ	1.62164771282925
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	2/92	70/9376	2.91180124223603	PAK3/PIK3CB	1.59816723009383
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	2/92	71/9376	2.87078995713411	FOS/PIK3CB	1.57509952831877
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	6/92	370/9376	1.65264394829612	CSH1/CNR2/FSHR/P2RY14/THRB/KISS1	1.27503818723492
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	2/92	75/9376	2.71768115942029	MGST1/PIK3CB	1.48668975126746
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	2/92	75/9376	2.71768115942029	PLCB2/GNAQ	1.48668975126746
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	3/92	144/9376	2.1231884057971	PLCB2/GNAQ/PIK3CB	1.35206616823141
Human Diseases	Cancer: specific types	hsa05214	Glioma	2/92	76/9376	2.68192219679634	CAMK2D/PIK3CB	1.46549118323793
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	2/92	78/9376	2.61315496098105	PTK2/PIK3CB	1.42410038706422
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	2/92	78/9376	2.61315496098105	FOS/IRF8	1.42410038706422
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	3/92	149/9376	2.05194047271666	PLCB2/PIK3CB/FYN	1.28844541535388
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	2/92	80/9376	2.54782608695652	AXL/PIK3CB	1.38398404640717
NA	NA	hsa04518	Integrin signaling	3/92	154/9376	1.98531902879729	PTK2/CCND3/PIK3CB	1.22726022054107
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	4/92	232/9376	1.75712143928036	PTK2/VAV3/PAK3/PIK3CB	1.16239414550379
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	3/92	155/9376	1.97251051893408	CAMK2D/PLCB2/GNAQ	1.2152989747475
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	2/92	86/9376	2.37007077856421	SLC8A1/CDH2	1.27056345084031
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	2/92	87/9376	2.34282858570715	FOS/PIK3CB	1.25258644794687
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	2/92	88/9376	2.31620553359684	CLU/CD55	1.23485490463182
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	2/92	89/9376	2.29018075232047	PLCB2/GNAQ	1.21736223535604
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	2/92	90/9376	2.26473429951691	FOS/PIK3CB	1.20010210578975
Human Diseases	Substance dependence	hsa05032	Morphine addiction	2/92	91/9376	2.23984710941233	GNAO1/ARRB1	1.18306842051075
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	3/92	169/9376	1.80910728067919	PIK3CB/UVRAG/RAB7B	1.05657997613893
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	2/92	93/9376	2.1916783543712	PTPRJ/FYN	1.14965712692221
Organismal Systems	Digestive system	hsa04970	Salivary secretion	2/92	93/9376	2.1916783543712	PLCB2/GNAQ	1.14965712692221
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	2/92	93/9376	2.1916783543712	PTK2/PIK3CB	1.14965712692221
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	2/92	94/9376	2.16836262719704	FOS/FOSB	1.13326842152915
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	4/92	253/9376	1.61127341467606	PTK2/PLCB2/PIK3CB/PRKCE	0.981157927367157
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	4/92	254/9376	1.60492981855529	CAMK2D/SLC8A1/PLCB2/GNAQ	0.972946147738619
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/92	28/9376	3.63975155279503	PPT1	1.39249839671199
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	2/92	99/9376	2.05884936319719	FOS/PIK3CB	1.05428975120372
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	3/92	178/9376	1.71763556424035	CAMK2D/CCND3/PLCB2	0.962230763538491
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	2/92	102/9376	1.99829497016198	PLCB2/GNAQ	1.00910744200774
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	5/92	362/9376	1.40763872207543	CSH1/PTK2/CCND3/IL4R/PIK3CB	0.787377364973767
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	2/92	110/9376	1.85296442687747	CAMK2D/PIK3CB	0.895762958952129
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	2/92	110/9376	1.85296442687747	SPDYE2/PIK3CB	0.895762958952129
Cellular Processes	Cell motility	hsa04814	Motor proteins	3/92	194/9376	1.57597489914836	MYO7B/KIF16B/MYO1F	0.806952114833797
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	3/92	196/9376	1.55989352262644	FOS/HCK/PIK3CB	0.788540718509378
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/92	38/9376	2.68192219679634	PIK3CB	1.03414813149788
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/92	38/9376	2.68192219679634	CIITA	1.03414813149788
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	2/92	119/9376	1.71282426013884	FOS/PIK3CB	0.778991657704567
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	2/92	120/9376	1.69855072463768	CAMK2D/PIK3CB	0.766635425171369
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	4/92	298/9376	1.36796031514444	CSH1/IL4R/CSF2RA/XCR1	0.642578234466795
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/92	43/9376	2.37007077856421	ABCA1	0.896351984774719
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/92	45/9376	2.26473429951691	ABCA1	0.846551619564407
NA	NA	hsa04519	Cadherin signaling	5/92	404/9376	1.26130004304778	PTK2/VAV3/CDH2/MYO1F/EVL	0.534438230449494
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	2/92	133/9376	1.53252696959791	BCL6/PIK3CB	0.615705364150313
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/92	49/9376	2.07985803016859	FOSB	0.754406983173024
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	2/92	137/9376	1.48778165661695	FOS/PIK3CB	0.572512865170138
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	2/92	138/9376	1.47700063011972	CAMK2D/SPDYE2	0.561929074079063
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	1/92	52/9376	1.95986622073579	FSHR	0.690912792350164
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	4/92	333/9376	1.22418070244157	PTK2/CCND3/PIK3CB/MX2	0.414644646877948
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	2/92	144/9376	1.41545893719807	ID2/PIK3CB	0.500119098786672
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	3/92	238/9376	1.28461819510413	REL/PAK3/PIK3CB	0.442728569280221
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	3/92	238/9376	1.28461819510413	FOS/PIK3CB/MX2	0.442728569280221
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	1/92	56/9376	1.81987577639752	MGAT5	0.612556423611711
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	1/92	56/9376	1.81987577639752	ARRB1	0.612556423611711
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	2/92	148/9376	1.37720329024677	FOS/PIK3CB	0.460430964862472
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/92	57/9376	1.78794813119756	PPT1	0.593967097021763
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	1/92	59/9376	1.72733971997052	MGST1	0.557875448590606
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1/92	59/9376	1.72733971997052	PIK3CB	0.557875448590606
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	1/92	59/9376	1.72733971997052	PIK3CB	0.557875448590606
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	5/92	449/9376	1.13488912559311	CAMK2D/SLC8A1/NCALD/SLC24A4/ARRB1	0.291581072124711
Organismal Systems	Digestive system	hsa04978	Mineral absorption	1/92	61/9376	1.67070563079116	SLC8A1	0.523139395571063
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	2/92	156/9376	1.30657748049052	PIK3CB/MX2	0.384369638630843
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	2/92	157/9376	1.29825533093326	CCND3/PIK3CB	0.375152737251013
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	2/92	157/9376	1.29825533093326	CCND3/ID2	0.375152737251013
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	1/92	62/9376	1.6437587657784	PIK3CB	0.506247474429177
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	2/92	158/9376	1.29003852504128	PIK3CB/FNIP2	0.365997286429652
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/92	65/9376	1.56789297658863	MBOAT2	0.457337694988411
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	2/92	163/9376	1.25046679114431	FOS/PIK3CB	0.321111163702631
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	1/92	68/9376	1.49872122762148	PIK3CB	0.410862125926524
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	2/92	170/9376	1.19897698209719	RAB8B/PRKCE	0.260617635939096
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	2/92	170/9376	1.19897698209719	MGST1/PIK3CB	0.260617635939096
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	1/92	70/9376	1.45590062111801	MGST1	0.381109404447326
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	1/92	71/9376	1.43539497856705	PIK3CB	0.366577991697102
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/92	73/9376	1.3960690887433	MGST1	0.338168269208233
Human Diseases	Cancer: specific types	hsa05218	Melanoma	1/92	73/9376	1.3960690887433	PIK3CB	0.338168269208233
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	1/92	73/9376	1.3960690887433	PIK3CB	0.338168269208233
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	1/92	75/9376	1.35884057971015	CCND3	0.310584190359283
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	1/92	77/9376	1.32354601919819	PIK3CB	0.28377575348238
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	1/92	77/9376	1.32354601919819	PIK3CB	0.28377575348238
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/92	79/9376	1.29003852504128	MGST1	0.257697261880213
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1/92	82/9376	1.24284199363733	MGST1	0.219857541716986
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	1/92	83/9376	1.22786799371399	AUTS2	0.207566084131856
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	1/92	83/9376	1.22786799371399	SAMHD1	0.207566084131856
Human Diseases	Substance dependence	hsa05034	Alcoholism	2/92	191/9376	1.06715228773048	FOSB/GNAO1	0.0933361541230627
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	3/92	300/9376	1.01913043478261	FOS/DUSP1/ARRB1	0.0335235660470793
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/92	86/9376	1.1850353892821	PLCB2	0.17159639225371
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	2/92	195/9376	1.04526198439242	PLCB2/PIK3CB	0.0635796142298419
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	1/92	89/9376	1.14509037616023	GNAO1	0.136901394888581
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	1/92	90/9376	1.13236714975845	PIK3CB	0.125602741400456
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	3/92	323/9376	0.946560775339884	PIK3CB/FOXP1/PRKCE	-0.0972920009499991
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	1/92	99/9376	1.02942468159859	SLC8A1	0.0292979731773741
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	1/92	100/9376	1.01913043478261	XCR1	0.0191450478646063
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	1/92	103/9376	0.989447024060785	SLC8A1	-0.0107200155762813
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	1/92	104/9376	0.979933110367893	MBOAT2	-0.0204843414409478
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	1/92	105/9376	0.970600414078675	CARD11	-0.0301567515906487
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	1/92	105/9376	0.970600414078675	RAB7B	-0.0301567515906487
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	1/92	105/9376	0.970600414078675	PIK3CB	-0.0301567515906487
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	1/92	105/9376	0.970600414078675	SLC8A1	-0.0301567515906487
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	1/92	106/9376	0.961443806398687	PIK3CB	-0.0397392076761501
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	1/92	110/9376	0.926482213438735	ID2	-0.0772066313091269
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	1/92	122/9376	0.835352815395581	PIK3CB	-0.182213882794255
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	2/92	250/9376	0.815304347826087	RAB31/ARRB1	-0.294644562031861
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	1/92	138/9376	0.738500315059861	PIK3CB	-0.308058871522868
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	1/92	142/9376	0.717697489283527	WWP2	-0.337423995530056
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	1/92	150/9376	0.679420289855073	PIK3CB	-0.393991563359259
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	1/92	158/9376	0.645019262520638	CCND3	-0.447947342973673
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	1/92	168/9376	0.606625258799172	CAMK2D	-0.512142057309023
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	1/92	187/9376	0.544989537316903	PLCB2	-0.625633573904346
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	1/92	250/9376	0.407652173913043	PPT1	-0.94497116598919