ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0005520 insulin-like growth factor binding 6/125 19/18639 0.315789473684211 47.088 2.03648221279724e-09 6.63893201371901e-07 GO:0031994 insulin-like growth factor I binding 5/125 13/18639 0.384615384615385 57.3507692307692 1.54309336364531e-08 2.51524218274185e-06 GO:0005201 extracellular matrix structural constituent 9/125 168/18639 0.0535714285714286 7.98814285714286 1.98088124361562e-06 0.00021525576180623 GO:0042605 peptide antigen binding 5/125 45/18639 0.111111111111111 16.568 1.23370880854841e-05 0.00100547267896695 GO:0003823 antigen binding 8/125 174/18639 0.0459770114942529 6.85572413793103 2.28321010300849e-05 0.00148865298716154 GO:0019838 growth factor binding 7/125 136/18639 0.0514705882352941 7.67488235294118 3.67630029148067e-05 0.0019974564917045 GO:0042608 T cell receptor binding 3/125 11/18639 0.272727272727273 40.6669090909091 4.67131830075073e-05 0.0021754996657782 GO:0030021 extracellular matrix structural constituent conferring compression resistance 3/125 22/18639 0.136363636363636 20.3334545454545 0.000413096415474247 0.0168336789305756 GO:0043548 phosphatidylinositol 3-kinase binding 3/125 26/18639 0.115384615384615 17.2052307692308 0.000683919145946377 0.0247730712865021 GO:0003785 actin monomer binding 3/125 29/18639 0.103448275862069 15.4253793103448 0.000947179158047129 0.0308780405523364 GO:0001968 fibronectin binding 3/125 30/18639 0.1 14.9112 0.00104729320684448 0.0310379623119364 GO:0005539 glycosaminoglycan binding 7/125 242/18639 0.0289256198347107 4.31315702479339 0.00124175558496599 0.0337343600582427 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 4/125 89/18639 0.0449438202247191 6.70166292134831 0.00303343728106355 0.0650171028985771 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 4/125 89/18639 0.0449438202247191 6.70166292134831 0.00303343728106355 0.0650171028985771 GO:0140793 histone H2AXY142 phosphatase activity 4/125 90/18639 0.0444444444444444 6.6272 0.00315829702341856 0.0650171028985771 GO:0030547 signaling receptor inhibitor activity 3/125 44/18639 0.0681818181818182 10.1667272727273 0.00319102345514489 0.0650171028985771 GO:0008191 metalloendopeptidase inhibitor activity 2/125 14/18639 0.142857142857143 21.3017142857143 0.00385155188297608 0.069755884102789 GO:0032036 myosin heavy chain binding 2/125 14/18639 0.142857142857143 21.3017142857143 0.00385155188297608 0.069755884102789 GO:0004725 protein tyrosine phosphatase activity 4/125 98/18639 0.0408163265306122 6.08620408163265 0.00428566851733872 0.0735330492974959 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 2/125 17/18639 0.117647058823529 17.5425882352941 0.0056810254664244 0.0881911572406835 GO:0019198 transmembrane receptor protein phosphatase activity 2/125 17/18639 0.117647058823529 17.5425882352941 0.0056810254664244 0.0881911572406835 GO:0008201 heparin binding 5/125 172/18639 0.0290697674418605 4.3346511627907 0.00608288163170725 0.0901372459971165 GO:0004721 phosphoprotein phosphatase activity 5/125 175/18639 0.0285714285714286 4.26034285714286 0.00653485162577908 0.0910364097031388 GO:0042277 peptide binding 6/125 249/18639 0.0240963855421687 3.59306024096386 0.00670206697201022 0.0910364097031388 GO:0016004 phospholipase activator activity 2/125 20/18639 0.1 14.9112 0.00783328424008024 0.102146026490646 GO:0003779 actin binding 8/125 443/18639 0.018058690744921 2.69276749435666 0.0100418166619586 0.124664551162583 GO:0050840 extracellular matrix binding 3/125 67/18639 0.0447761194029851 6.67665671641791 0.0103249781637722 0.124664551162583 GO:0060229 lipase activator activity 2/125 24/18639 0.0833333333333333 12.426 0.0111819276556149 0.130189586276088 GO:0005518 collagen binding 3/125 72/18639 0.0416666666666667 6.213 0.0125478764362373 0.140152376373532 GO:0050750 low-density lipoprotein particle receptor binding 2/125 26/18639 0.0769230769230769 11.4701538461538 0.0130528590297496 0.140152376373532 GO:0140789 histone phosphatase activity 4/125 136/18639 0.0294117647058824 4.38564705882353 0.013327373213434 0.140152376373532 GO:0023026 MHC class II protein complex binding 2/125 27/18639 0.0740740740740741 11.0453333333333 0.0140358352225247 0.14299007132947 GO:0019903 protein phosphatase binding 4/125 144/18639 0.0277777777777778 4.142 0.0161250646863944 0.159296093568624 GO:0048019 receptor antagonist activity 2/125 30/18639 0.0666666666666667 9.9408 0.0171693177723204 0.164623458640484 GO:0070325 lipoprotein particle receptor binding 2/125 31/18639 0.0645161290322581 9.62012903225807 0.0182738324440028 0.170207696478426 GO:0004857 enzyme inhibitor activity 7/125 416/18639 0.0168269230769231 2.50909615384615 0.0221410296943025 0.200499324453961 GO:0005178 integrin binding 4/125 161/18639 0.0248447204968944 3.70464596273292 0.0232250907758337 0.204631880889778 GO:0023023 MHC protein complex binding 2/125 37/18639 0.0540540540540541 8.06010810810811 0.0255005574484922 0.213158505851499 GO:0043394 proteoglycan binding 2/125 37/18639 0.0540540540540541 8.06010810810811 0.0255005574484922 0.213158505851499 GO:0000146 microfilament motor activity 2/125 38/18639 0.0526315789473684 7.848 0.0268009875062932 0.21842804817629 GO:0042169 SH2 domain binding 2/125 41/18639 0.0487804878048781 7.27375609756098 0.0308585515442015 0.244589663938675 GO:0008307 structural constituent of muscle 2/125 42/18639 0.0476190476190476 7.10057142857143 0.0322618268385369 0.244589663938675 GO:0042056 chemoattractant activity 2/125 42/18639 0.0476190476190476 7.10057142857143 0.0322618268385369 0.244589663938675 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 5/125 268/18639 0.0186567164179104 2.78194029850746 0.0345400464363968 0.250887891297117 GO:0042578 phosphoric ester hydrolase activity 6/125 363/18639 0.0165289256198347 2.46466115702479 0.0356862450500576 0.250887891297117 GO:0004715 non-membrane spanning protein tyrosine kinase activity 2/125 45/18639 0.0444444444444444 6.6272 0.0366184130310139 0.250887891297117 GO:0008009 chemokine activity 2/125 45/18639 0.0444444444444444 6.6272 0.0366184130310139 0.250887891297117 GO:0016791 phosphatase activity 5/125 273/18639 0.0183150183150183 2.73098901098901 0.0369405484118454 0.250887891297117 GO:1901681 sulfur compound binding 5/125 275/18639 0.0181818181818182 2.71112727272727 0.0379288552435108 0.252116765186779 GO:0019902 phosphatase binding 4/125 190/18639 0.0210526315789474 3.1392 0.0391574088216556 0.252116765186779 GO:0001217 DNA-binding transcription repressor activity 5/125 278/18639 0.0179856115107914 2.68187050359712 0.0394415798298336 0.252116765186779 GO:0017124 SH3 domain binding 3/125 115/18639 0.0260869565217391 3.88987826086957 0.0422844848492803 0.26509119347818 GO:0048020 CCR chemokine receptor binding 2/125 50/18639 0.04 5.96448 0.0443457372367879 0.272768119607413 GO:0140313 molecular sequestering activity 2/125 55/18639 0.0363636363636364 5.42225454545455 0.0526162115500621 0.317646017876301 GO:0015026 coreceptor activity 2/125 61/18639 0.0327868852459016 4.88891803278689 0.0631962536734814 0.342127511164381 GO:0002020 protease binding 3/125 136/18639 0.0220588235294118 3.28923529411765 0.0635773472145601 0.342127511164381 GO:0005031 tumor necrosis factor receptor activity 1/125 10/18639 0.1 14.9112 0.0650908096761579 0.342127511164381 GO:0005522 profilin binding 1/125 10/18639 0.1 14.9112 0.0650908096761579 0.342127511164381 GO:0005528 FK506 binding 1/125 10/18639 0.1 14.9112 0.0650908096761579 0.342127511164381 GO:0030957 Tat protein binding 1/125 10/18639 0.1 14.9112 0.0650908096761579 0.342127511164381 GO:0070097 delta-catenin binding 1/125 10/18639 0.1 14.9112 0.0650908096761579 0.342127511164381 GO:0061134 peptidase regulator activity 4/125 226/18639 0.0176991150442478 2.63915044247788 0.0658271060784702 0.342127511164381 GO:0008199 ferric iron binding 1/125 11/18639 0.0909090909090909 13.5556363636364 0.0713640207336745 0.342127511164381 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 1/125 11/18639 0.0909090909090909 13.5556363636364 0.0713640207336745 0.342127511164381 GO:0045294 alpha-catenin binding 1/125 11/18639 0.0909090909090909 13.5556363636364 0.0713640207336745 0.342127511164381 GO:0050786 RAGE receptor binding 1/125 11/18639 0.0909090909090909 13.5556363636364 0.0713640207336745 0.342127511164381 GO:0050998 nitric-oxide synthase binding 1/125 11/18639 0.0909090909090909 13.5556363636364 0.0713640207336745 0.342127511164381 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 1/125 11/18639 0.0909090909090909 13.5556363636364 0.0713640207336745 0.342127511164381 GO:1990841 promoter-specific chromatin binding 2/125 68/18639 0.0294117647058824 4.38564705882353 0.0763536644611754 0.346522250388332 GO:0005095 GTPase inhibitor activity 1/125 12/18639 0.0833333333333333 12.426 0.077595473246467 0.346522250388332 GO:0005527 macrolide binding 1/125 12/18639 0.0833333333333333 12.426 0.077595473246467 0.346522250388332 GO:0045295 gamma-catenin binding 1/125 12/18639 0.0833333333333333 12.426 0.077595473246467 0.346522250388332 GO:0097677 STAT family protein binding 1/125 12/18639 0.0833333333333333 12.426 0.077595473246467 0.346522250388332 GO:0005035 death receptor activity 1/125 13/18639 0.0769230769230769 11.4701538461538 0.0837854429594738 0.352026304469707 GO:0039706 co-receptor binding 1/125 13/18639 0.0769230769230769 11.4701538461538 0.0837854429594738 0.352026304469707 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 1/125 13/18639 0.0769230769230769 11.4701538461538 0.0837854429594738 0.352026304469707 GO:0071837 HMG box domain binding 1/125 13/18639 0.0769230769230769 11.4701538461538 0.0837854429594738 0.352026304469707 GO:0042379 chemokine receptor binding 2/125 72/18639 0.0277777777777778 4.142 0.0842271526031814 0.352026304469707 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 5/125 349/18639 0.0143266475644699 2.13627507163324 0.0859893842733207 0.354842269279779 GO:0004065 arylsulfatase activity 1/125 14/18639 0.0714285714285714 10.6508571428571 0.0899342038115121 0.355792058076408 GO:0044548 S100 protein binding 1/125 14/18639 0.0714285714285714 10.6508571428571 0.0899342038115121 0.355792058076408 GO:0017022 myosin binding 2/125 76/18639 0.0263157894736842 3.924 0.0923353821777342 0.355792058076408 GO:0004866 endopeptidase inhibitor activity 3/125 161/18639 0.0186335403726708 2.77848447204969 0.0941223142064426 0.355792058076408 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 1/125 15/18639 0.0666666666666667 9.9408 0.0960420279470059 0.355792058076408 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 1/125 15/18639 0.0666666666666667 9.9408 0.0960420279470059 0.355792058076408 GO:0005523 tropomyosin binding 1/125 15/18639 0.0666666666666667 9.9408 0.0960420279470059 0.355792058076408 GO:0031386 protein tag activity 1/125 15/18639 0.0666666666666667 9.9408 0.0960420279470059 0.355792058076408 GO:0141047 molecular tag activity 1/125 15/18639 0.0666666666666667 9.9408 0.0960420279470059 0.355792058076408 GO:0048306 calcium-dependent protein binding 2/125 80/18639 0.025 3.7278 0.100660568032772 0.361821679861003 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 1/125 16/18639 0.0625 9.3195 0.102109185727645 0.361821679861003 GO:0005521 lamin binding 1/125 16/18639 0.0625 9.3195 0.102109185727645 0.361821679861003 GO:0019841 retinol binding 1/125 16/18639 0.0625 9.3195 0.102109185727645 0.361821679861003 GO:0030414 peptidase inhibitor activity 3/125 169/18639 0.0177514792899408 2.64695857988166 0.10496617624151 0.367211649088902 GO:0008484 sulfuric ester hydrolase activity 1/125 17/18639 0.0588235294117647 8.77129411764706 0.108135945743971 0.367211649088902 GO:0045125 bioactive lipid receptor activity 1/125 17/18639 0.0588235294117647 8.77129411764706 0.108135945743971 0.367211649088902 GO:0070492 oligosaccharide binding 1/125 17/18639 0.0588235294117647 8.77129411764706 0.108135945743971 0.367211649088902 GO:0030695 GTPase regulator activity 6/125 489/18639 0.0122699386503067 1.82959509202454 0.111226814520277 0.368995127716473 GO:0060589 nucleoside-triphosphatase regulator activity 6/125 490/18639 0.0122448979591837 1.8258612244898 0.112021634378448 0.368995127716473 GO:0070064 proline-rich region binding 1/125 18/18639 0.0555555555555556 8.284 0.114122574826884 0.368995127716473 GO:0004252 serine-type endopeptidase activity 3/125 176/18639 0.0170454545454545 2.54168181818182 0.114839410630064 0.368995127716473 GO:0016918 retinal binding 1/125 19/18639 0.0526315789473684 7.848 0.120069338059076 0.368995127716473 GO:0030506 ankyrin binding 1/125 19/18639 0.0526315789473684 7.848 0.120069338059076 0.368995127716473 GO:0034987 immunoglobulin receptor binding 1/125 19/18639 0.0526315789473684 7.848 0.120069338059076 0.368995127716473 GO:0043395 heparan sulfate proteoglycan binding 1/125 19/18639 0.0526315789473684 7.848 0.120069338059076 0.368995127716473 GO:0070003 threonine-type peptidase activity 1/125 19/18639 0.0526315789473684 7.848 0.120069338059076 0.368995127716473 GO:0019210 kinase inhibitor activity 2/125 90/18639 0.0222222222222222 3.3136 0.122312835858092 0.368995127716473 GO:0001614 purinergic nucleotide receptor activity 1/125 20/18639 0.05 7.4556 0.125976498786391 0.368995127716473 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 1/125 20/18639 0.05 7.4556 0.125976498786391 0.368995127716473 GO:0016502 nucleotide receptor activity 1/125 20/18639 0.05 7.4556 0.125976498786391 0.368995127716473 GO:0042288 MHC class I protein binding 1/125 20/18639 0.05 7.4556 0.125976498786391 0.368995127716473 GO:0061135 endopeptidase regulator activity 3/125 184/18639 0.016304347826087 2.43117391304348 0.126535053372938 0.368995127716473 GO:0043178 alcohol binding 2/125 92/18639 0.0217391304347826 3.2415652173913 0.12677133222161 0.368995127716473 GO:0008373 sialyltransferase activity 1/125 21/18639 0.0476190476190476 7.10057142857143 0.131844318629116 0.373749981505148 GO:0009931 calcium-dependent protein serine/threonine kinase activity 1/125 21/18639 0.0476190476190476 7.10057142857143 0.131844318629116 0.373749981505148 GO:0072542 protein phosphatase activator activity 1/125 21/18639 0.0476190476190476 7.10057142857143 0.131844318629116 0.373749981505148 GO:0004175 endopeptidase activity 5/125 405/18639 0.0123456790123457 1.84088888888889 0.136704697954716 0.383351880225591 GO:0015377 chloride:monoatomic cation symporter activity 1/125 22/18639 0.0454545454545455 6.77781818181818 0.137673057493192 0.383351880225591 GO:0001664 G protein-coupled receptor binding 4/125 297/18639 0.0134680134680135 2.00824242424242 0.139312912749131 0.383351880225591 GO:0008236 serine-type peptidase activity 3/125 194/18639 0.0154639175257732 2.30585567010309 0.141726303290299 0.383351880225591 GO:0004022 alcohol dehydrogenase (NAD+) activity 1/125 23/18639 0.0434782608695652 6.48313043478261 0.143462973581356 0.383351880225591 GO:0043274 phospholipase binding 1/125 23/18639 0.0434782608695652 6.48313043478261 0.143462973581356 0.383351880225591 GO:0099186 structural constituent of postsynapse 1/125 23/18639 0.0434782608695652 6.48313043478261 0.143462973581356 0.383351880225591 GO:0031625 ubiquitin protein ligase binding 4/125 302/18639 0.0132450331125828 1.97499337748344 0.145399205423627 0.385366999740669 GO:0017171 serine hydrolase activity 3/125 198/18639 0.0151515151515152 2.25927272727273 0.147967916033153 0.389012424409741 GO:0015296 monoatomic anion:monoatomic cation symporter activity 1/125 25/18639 0.04 5.96448 0.15492736179124 0.397888231287762 GO:0019211 phosphatase activator activity 1/125 25/18639 0.04 5.96448 0.15492736179124 0.397888231287762 GO:0008013 beta-catenin binding 2/125 106/18639 0.0188679245283019 2.81343396226415 0.158955029477342 0.397888231287762 GO:0004435 phosphatidylinositol phospholipase C activity 1/125 26/18639 0.0384615384615385 5.73507692307692 0.160602341901699 0.397888231287762 GO:0008198 ferrous iron binding 1/125 26/18639 0.0384615384615385 5.73507692307692 0.160602341901699 0.397888231287762 GO:0030507 spectrin binding 1/125 26/18639 0.0384615384615385 5.73507692307692 0.160602341901699 0.397888231287762 GO:0050681 nuclear androgen receptor binding 1/125 26/18639 0.0384615384615385 5.73507692307692 0.160602341901699 0.397888231287762 GO:0019888 protein phosphatase regulator activity 2/125 107/18639 0.0186915887850467 2.78714018691589 0.161310153936815 0.397888231287762 GO:0005516 calmodulin binding 3/125 207/18639 0.0144927536231884 2.16104347826087 0.162328634237032 0.397888231287762 GO:0005496 steroid binding 2/125 108/18639 0.0185185185185185 2.76133333333333 0.163671717728901 0.398186417758371 GO:0051015 actin filament binding 3/125 209/18639 0.0143540669856459 2.14036363636364 0.165576120934347 0.398485896814539 GO:0008395 steroid hydroxylase activity 1/125 27/18639 0.037037037037037 5.52266666666667 0.166239515235513 0.398485896814539 GO:0044389 ubiquitin-like protein ligase binding 4/125 322/18639 0.0124223602484472 1.85232298136646 0.170741739996769 0.405938818231581 GO:0051393 alpha-actinin binding 1/125 28/18639 0.0357142857142857 5.32542857142857 0.171839131644044 0.405938818231581 GO:0005200 structural constituent of cytoskeleton 2/125 112/18639 0.0178571428571429 2.66271428571429 0.173178597830529 0.406159876926276 GO:0004629 phospholipase C activity 1/125 29/18639 0.0344827586206897 5.14179310344828 0.177401439340809 0.408452734803811 GO:0043236 laminin binding 1/125 29/18639 0.0344827586206897 5.14179310344828 0.177401439340809 0.408452734803811 GO:0035401 histone H3Y41 kinase activity 2/125 115/18639 0.0173913043478261 2.59325217391304 0.180367276206298 0.408452734803811 GO:0140801 histone H2AXY142 kinase activity 2/125 115/18639 0.0173913043478261 2.59325217391304 0.180367276206298 0.408452734803811 GO:0008106 alcohol dehydrogenase (NADP+) activity 1/125 30/18639 0.0333333333333333 4.9704 0.182926684912136 0.408452734803811 GO:0051721 protein phosphatase 2A binding 1/125 30/18639 0.0333333333333333 4.9704 0.182926684912136 0.408452734803811 GO:0098918 structural constituent of synapse 1/125 30/18639 0.0333333333333333 4.9704 0.182926684912136 0.408452734803811 GO:0019208 phosphatase regulator activity 2/125 117/18639 0.0170940170940171 2.54892307692308 0.185184922257164 0.410682208543098 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1/125 32/18639 0.03125 4.65975 0.193866967951237 0.424165312430224 GO:0051059 NF-kappaB binding 1/125 32/18639 0.03125 4.65975 0.193866967951237 0.424165312430224 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 2/125 122/18639 0.0163934426229508 2.44445901639344 0.197307249738744 0.427408499470337 GO:0030296 protein tyrosine kinase activator activity 1/125 33/18639 0.0303030303030303 4.51854545454546 0.199282490550587 0.427408499470337 GO:0140311 protein sequestering activity 1/125 33/18639 0.0303030303030303 4.51854545454546 0.199282490550587 0.427408499470337 GO:0019825 oxygen binding 1/125 34/18639 0.0294117647058824 4.38564705882353 0.20466192130847 0.435976323068973 GO:0005125 cytokine activity 3/125 234/18639 0.0128205128205128 1.91169230769231 0.207647042120635 0.435976323068973 GO:0016229 steroid dehydrogenase activity 1/125 35/18639 0.0285714285714286 4.26034285714286 0.2100054988326 0.435976323068973 GO:0031490 chromatin DNA binding 2/125 128/18639 0.015625 2.329875 0.211978245462376 0.435976323068973 GO:0004033 aldo-keto reductase (NADPH) activity 1/125 36/18639 0.0277777777777778 4.142 0.215313460165965 0.435976323068973 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 1/125 36/18639 0.0277777777777778 4.142 0.215313460165965 0.435976323068973 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 1/125 36/18639 0.0277777777777778 4.142 0.215313460165965 0.435976323068973 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 1/125 36/18639 0.0277777777777778 4.142 0.215313460165965 0.435976323068973 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 1/125 36/18639 0.0277777777777778 4.142 0.215313460165965 0.435976323068973 GO:0140996 histone H3 kinase activity 4/125 357/18639 0.0112044817927171 1.67072268907563 0.21838086431843 0.437206901181143 GO:0022829 wide pore channel activity 1/125 37/18639 0.027027027027027 4.03005405405405 0.220586040797006 0.437206901181143 GO:0042805 actinin binding 1/125 37/18639 0.027027027027027 4.03005405405405 0.220586040797006 0.437206901181143 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 2/125 132/18639 0.0151515151515152 2.25927272727273 0.221818722226362 0.437206901181143 GO:0035173 histone kinase activity 4/125 360/18639 0.0111111111111111 1.6568 0.222626826981809 0.437206901181143 GO:0005501 retinoid binding 1/125 38/18639 0.0263157894736842 3.924 0.225823474669728 0.438205075847211 GO:0019840 isoprenoid binding 1/125 38/18639 0.0263157894736842 3.924 0.225823474669728 0.438205075847211 GO:0140297 DNA-binding transcription factor binding 5/125 488/18639 0.0102459016393443 1.5277868852459 0.230214110465835 0.440435521094513 GO:0033218 amide binding 3/125 247/18639 0.0121457489878543 1.81107692307692 0.230409203562899 0.440435521094513 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 1/125 39/18639 0.0256410256410256 3.82338461538462 0.231025994193748 0.440435521094513 GO:0071855 neuropeptide receptor binding 1/125 40/18639 0.025 3.7278 0.236193830254274 0.447669701528449 GO:0001530 lipopolysaccharide binding 1/125 41/18639 0.024390243902439 3.63687804878049 0.241327212222025 0.448798860089196 GO:0042287 MHC protein binding 1/125 41/18639 0.024390243902439 3.63687804878049 0.241327212222025 0.448798860089196 GO:0004713 protein tyrosine kinase activity 2/125 140/18639 0.0142857142857143 2.13017142857143 0.241601746405373 0.448798860089196 GO:0016859 cis-trans isomerase activity 1/125 42/18639 0.0238095238095238 3.55028571428571 0.246426367963086 0.448798860089196 GO:0019894 kinesin binding 1/125 42/18639 0.0238095238095238 3.55028571428571 0.246426367963086 0.448798860089196 GO:0031492 nucleosomal DNA binding 1/125 42/18639 0.0238095238095238 3.55028571428571 0.246426367963086 0.448798860089196 GO:0035198 miRNA binding 1/125 42/18639 0.0238095238095238 3.55028571428571 0.246426367963086 0.448798860089196 GO:0048156 tau protein binding 1/125 43/18639 0.0232558139534884 3.46772093023256 0.251491523848692 0.455479093192631 GO:0016790 thiolester hydrolase activity 1/125 44/18639 0.0227272727272727 3.38890909090909 0.25652290476496 0.462024679300425 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 1/125 46/18639 0.0217391304347826 3.2415652173913 0.266485233866267 0.477330693628587 GO:0001784 phosphotyrosine residue binding 1/125 47/18639 0.0212765957446809 3.17259574468085 0.271416624484602 0.47747796804254 GO:0005504 fatty acid binding 1/125 47/18639 0.0212765957446809 3.17259574468085 0.271416624484602 0.47747796804254 GO:0043495 protein-membrane adaptor activity 1/125 47/18639 0.0212765957446809 3.17259574468085 0.271416624484602 0.47747796804254 GO:0005096 GTPase activator activity 3/125 271/18639 0.011070110701107 1.65068634686347 0.273503886898619 0.47747796804254 GO:0003774 cytoskeletal motor activity 2/125 153/18639 0.0130718954248366 1.94917647058824 0.273890736269801 0.47747796804254 GO:0005506 iron ion binding 2/125 154/18639 0.012987012987013 1.93651948051948 0.276375593675258 0.479247040096458 GO:0005126 cytokine receptor binding 3/125 275/18639 0.0109090909090909 1.62667636363636 0.28078101467471 0.482447319485417 GO:0001222 transcription corepressor binding 1/125 49/18639 0.0204081632653061 3.04310204081633 0.281180953074323 0.482447319485417 GO:0030246 carbohydrate binding 3/125 280/18639 0.0107142857142857 1.59762857142857 0.289903045321821 0.489847154937722 GO:0005080 protein kinase C binding 1/125 52/18639 0.0192307692307692 2.86753846153846 0.29558455703977 0.489847154937722 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 1/125 52/18639 0.0192307692307692 2.86753846153846 0.29558455703977 0.489847154937722 GO:0030159 signaling receptor complex adaptor activity 1/125 52/18639 0.0192307692307692 2.86753846153846 0.29558455703977 0.489847154937722 GO:0008083 growth factor activity 2/125 162/18639 0.0123456790123457 1.84088888888889 0.296231305834545 0.489847154937722 GO:0004864 protein phosphatase inhibitor activity 1/125 53/18639 0.0188679245283019 2.81343396226415 0.300321842797022 0.489847154937722 GO:0005246 calcium channel regulator activity 1/125 53/18639 0.0188679245283019 2.81343396226415 0.300321842797022 0.489847154937722 GO:0016251 RNA polymerase II general transcription initiation factor activity 1/125 53/18639 0.0188679245283019 2.81343396226415 0.300321842797022 0.489847154937722 GO:0017046 peptide hormone binding 1/125 53/18639 0.0188679245283019 2.81343396226415 0.300321842797022 0.489847154937722 GO:0019207 kinase regulator activity 3/125 287/18639 0.0104529616724739 1.55866202090592 0.302711050078941 0.489847154937722 GO:0015485 cholesterol binding 1/125 54/18639 0.0185185185185185 2.76133333333333 0.305027522859992 0.489847154937722 GO:0050661 NADP binding 1/125 54/18639 0.0185185185185185 2.76133333333333 0.305027522859992 0.489847154937722 GO:0140463 chromatin-protein adaptor activity 1/125 54/18639 0.0185185185185185 2.76133333333333 0.305027522859992 0.489847154937722 GO:0019212 phosphatase inhibitor activity 1/125 56/18639 0.0178571428571429 2.66271428571429 0.314344901226254 0.502335479410582 GO:0016504 peptidase activator activity 1/125 57/18639 0.0175438596491228 2.616 0.31895701376711 0.507219446283306 GO:0061980 regulatory RNA binding 1/125 58/18639 0.0172413793103448 2.57089655172414 0.323538349106638 0.512007290333806 GO:0001786 phosphatidylserine binding 1/125 59/18639 0.0169491525423729 2.5273220338983 0.328089110979609 0.512104238008858 GO:0045309 protein phosphorylated amino acid binding 1/125 59/18639 0.0169491525423729 2.5273220338983 0.328089110979609 0.512104238008858 GO:0003735 structural constituent of ribosome 2/125 175/18639 0.0114285714285714 1.70413714285714 0.328312226208133 0.512104238008858 GO:0019843 rRNA binding 1/125 65/18639 0.0153846153846154 2.29403076923077 0.35476288110174 0.55072713923413 GO:0032934 sterol binding 1/125 68/18639 0.0147058823529412 2.19282352941176 0.367703122734082 0.565430273638257 GO:0140223 general transcription initiation factor activity 1/125 68/18639 0.0147058823529412 2.19282352941176 0.367703122734082 0.565430273638257 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 1/125 73/18639 0.0136986301369863 2.0426301369863 0.388700524030677 0.594912539126764 GO:0031491 nucleosome binding 1/125 74/18639 0.0135135135135135 2.01502702702703 0.39281624279057 0.598402313783765 GO:0003725 double-stranded RNA binding 1/125 75/18639 0.0133333333333333 1.98816 0.396904471697178 0.59903174895037 GO:0044183 protein folding chaperone 1/125 75/18639 0.0133333333333333 1.98816 0.396904471697178 0.59903174895037 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 4/125 484/18639 0.00826446280991736 1.2323305785124 0.408555253918087 0.613774252429938 GO:0033293 monocarboxylic acid binding 1/125 79/18639 0.0126582278481013 1.88749367088608 0.412986113686944 0.617584738816255 GO:0001216 DNA-binding transcription activator activity 4/125 491/18639 0.00814663951120163 1.2147617107943 0.419134811602587 0.623647890712504 GO:0030971 receptor tyrosine kinase binding 1/125 81/18639 0.0123456790123457 1.84088888888889 0.420866674713959 0.623647890712504 GO:0141003 histone H2AX kinase activity 3/125 354/18639 0.00847457627118644 1.26366101694915 0.424752681588228 0.626558254288518 GO:0001540 amyloid-beta binding 1/125 83/18639 0.0120481927710843 1.79653012048193 0.428642275636362 0.629429084598824 GO:0004860 protein kinase inhibitor activity 1/125 84/18639 0.0119047619047619 1.77514285714286 0.432491150153793 0.629429084598824 GO:0051117 ATPase binding 1/125 84/18639 0.0119047619047619 1.77514285714286 0.432491150153793 0.629429084598824 GO:0008081 phosphoric diester hydrolase activity 1/125 87/18639 0.0114942528735632 1.71393103448276 0.443884126288206 0.643138778533134 GO:0004197 cysteine-type endopeptidase activity 1/125 88/18639 0.0113636363636364 1.69445454545455 0.447631133846096 0.645698007229324 GO:0005085 guanyl-nucleotide exchange factor activity 2/125 230/18639 0.00869565217391304 1.29662608695652 0.457988397982784 0.6558927596086 GO:0072341 modified amino acid binding 1/125 91/18639 0.010989010989011 1.63859340659341 0.458722543529941 0.6558927596086 GO:0052689 carboxylic ester hydrolase activity 1/125 92/18639 0.0108695652173913 1.62078260869565 0.462370359038824 0.658221559155706 GO:0051219 phosphoprotein binding 1/125 93/18639 0.010752688172043 1.60335483870968 0.465993786284208 0.660495540559356 GO:0042562 hormone binding 1/125 94/18639 0.0106382978723404 1.58629787234043 0.469592987012909 0.662715644009559 GO:0004867 serine-type endopeptidase inhibitor activity 1/125 95/18639 0.0105263157894737 1.5696 0.473168121907672 0.664882791990953 GO:0004896 cytokine receptor activity 1/125 96/18639 0.0104166666666667 1.55325 0.476719350594123 0.666997889672463 GO:0008170 N-methyltransferase activity 1/125 98/18639 0.0102040816326531 1.52155102040816 0.48375072260031 0.673943314391885 GO:0035403 histone H3T6 kinase activity 2/125 247/18639 0.00809716599190283 1.20738461538462 0.495189515033399 0.684032974156305 GO:0042393 histone binding 2/125 247/18639 0.00809716599190283 1.20738461538462 0.495189515033399 0.684032974156305 GO:0004722 protein serine/threonine phosphatase activity 1/125 103/18639 0.00970873786407767 1.44768932038835 0.500921767289452 0.689031629267347 GO:0004497 monooxygenase activity 1/125 106/18639 0.00943396226415094 1.40671698113208 0.510951171472516 0.698491974975297 GO:0019887 protein kinase regulator activity 2/125 255/18639 0.00784313725490196 1.16950588235294 0.51213508231365 0.698491974975297 GO:0003713 transcription coactivator activity 2/125 256/18639 0.0078125 1.1649375 0.514227220840709 0.698491974975297 GO:0004620 phospholipase activity 1/125 109/18639 0.00917431192660551 1.368 0.520780606394656 0.704458413629286 GO:0004222 metalloendopeptidase activity 1/125 110/18639 0.00909090909090909 1.35556363636364 0.52401333301099 0.705902258518937 GO:0001221 transcription coregulator binding 1/125 115/18639 0.00869565217391304 1.29662608695652 0.539855312957922 0.722469717479535 GO:0009055 electron transfer activity 1/125 116/18639 0.00862068965517241 1.28544827586207 0.542960370498424 0.722469717479535 GO:0015294 solute:monoatomic cation symporter activity 1/125 116/18639 0.00862068965517241 1.28544827586207 0.542960370498424 0.722469717479535 GO:1990782 protein tyrosine kinase binding 1/125 117/18639 0.00854700854700855 1.27446153846154 0.546044641603951 0.723620134808489 GO:0015108 chloride transmembrane transporter activity 1/125 121/18639 0.00826446280991736 1.2323305785124 0.558176608823888 0.736702730674443 GO:0008528 G protein-coupled peptide receptor activity 1/125 122/18639 0.00819672131147541 1.22222950819672 0.561159000221286 0.737652556742497 GO:0031267 small GTPase binding 2/125 283/18639 0.00706713780918728 1.05379505300353 0.568460350085829 0.744249293686668 GO:0042826 histone deacetylase binding 1/125 127/18639 0.0078740157480315 1.17411023622047 0.575774021577907 0.748556226233664 GO:0001653 peptide receptor activity 1/125 128/18639 0.0078125 1.1649375 0.578638555248108 0.748556226233664 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 1/125 128/18639 0.0078125 1.1649375 0.578638555248108 0.748556226233664 GO:0035591 signaling adaptor activity 1/125 129/18639 0.00775193798449612 1.15590697674419 0.581483900210238 0.749263839796592 GO:0016298 lipase activity 1/125 130/18639 0.00769230769230769 1.14701538461538 0.584310183974351 0.749941417226922 GO:0005179 hormone activity 1/125 132/18639 0.00757575757575758 1.12963636363636 0.589906073751891 0.754154431541633 GO:0051087 protein-folding chaperone binding 1/125 134/18639 0.00746268656716418 1.11277611940299 0.59542722795045 0.758239360593151 GO:0099094 ligand-gated monoatomic cation channel activity 1/125 136/18639 0.00735294117647059 1.09641176470588 0.600874636754016 0.762198955571242 GO:0016922 nuclear receptor binding 1/125 137/18639 0.0072992700729927 1.08840875912409 0.603570992502043 0.762651719208008 GO:0030295 protein kinase activator activity 1/125 139/18639 0.00719424460431655 1.07274820143885 0.608909611386743 0.766426769544703 GO:0020037 heme binding 1/125 142/18639 0.00704225352112676 1.05008450704225 0.616784098442569 0.773352369585682 GO:0019955 cytokine binding 1/125 144/18639 0.00694444444444444 1.0355 0.621946169760664 0.776836978321749 GO:0051020 GTPase binding 2/125 315/18639 0.00634920634920635 0.946742857142857 0.626961493469587 0.777242574336672 GO:0015293 symporter activity 1/125 146/18639 0.00684931506849315 1.02131506849315 0.627039254756272 0.777242574336672 GO:0019209 kinase activator activity 1/125 148/18639 0.00675675675675676 1.00751351351351 0.632064268031637 0.780503603705734 GO:0008509 monoatomic anion transmembrane transporter activity 1/125 149/18639 0.00671140939597315 1.00075167785235 0.634551530294146 0.780618108965629 GO:0019842 vitamin binding 1/125 150/18639 0.00666666666666667 0.99408 0.637022112160735 0.78071131039248 GO:0046906 tetrapyrrole binding 1/125 152/18639 0.00657894736842105 0.981 0.641913677846181 0.783759771452641 GO:0140375 immune receptor activity 1/125 156/18639 0.00641025641025641 0.955846153846154 0.651501478267053 0.792498066847236 GO:0015079 potassium ion transmembrane transporter activity 1/125 160/18639 0.00625 0.93195 0.660834563323463 0.797896546827589 GO:0099106 ion channel regulator activity 1/125 160/18639 0.00625 0.93195 0.660834563323463 0.797896546827589 GO:0015103 inorganic anion transmembrane transporter activity 1/125 165/18639 0.00606060606060606 0.903709090909091 0.67215293742589 0.808567740224502 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 1/125 167/18639 0.00598802395209581 0.89288622754491 0.676574648018903 0.81053782061358 GO:0016247 channel regulator activity 1/125 168/18639 0.00595238095238095 0.887571428571429 0.678763266955544 0.81053782061358 GO:0141108 transporter regulator activity 1/125 170/18639 0.00588235294117647 0.877129411764706 0.683096524592497 0.812735281084504 GO:0005319 lipid transporter activity 1/125 178/18639 0.00561797752808989 0.837707865168539 0.69985729127655 0.826940904667635 GO:0106310 protein serine kinase activity 2/125 361/18639 0.00554016620498615 0.826105263157895 0.700109477571372 0.826940904667635 GO:0016853 isomerase activity 1/125 180/18639 0.00555555555555556 0.8284 0.703908191084993 0.827797558104631 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 1/125 181/18639 0.00552486187845304 0.82382320441989 0.70591325507082 0.827797558104631 GO:0008237 metallopeptidase activity 1/125 184/18639 0.00543478260869565 0.810391304347826 0.711847985927731 0.828173517162129 GO:0015276 ligand-gated monoatomic ion channel activity 1/125 186/18639 0.00537634408602151 0.801677419354839 0.71573831250926 0.828173517162129 GO:0008234 cysteine-type peptidase activity 1/125 187/18639 0.0053475935828877 0.797390374331551 0.717663891598641 0.828173517162129 GO:0031406 carboxylic acid binding 1/125 187/18639 0.0053475935828877 0.797390374331551 0.717663891598641 0.828173517162129 GO:0022834 ligand-gated channel activity 1/125 188/18639 0.00531914893617021 0.793148936170213 0.719576530529389 0.828173517162129 GO:0043177 organic acid binding 1/125 189/18639 0.00529100529100529 0.788952380952381 0.721476315564554 0.828173517162129 GO:0008168 methyltransferase activity 1/125 204/18639 0.00490196078431373 0.730941176470588 0.748487568643018 0.856164727640786 GO:0016741 transferase activity, transferring one-carbon groups 1/125 215/18639 0.00465116279069767 0.693544186046512 0.766628491990311 0.858383774127472 GO:0004674 protein serine/threonine kinase activity 2/125 433/18639 0.0046189376443418 0.688739030023095 0.79058397829451 0.858383774127472 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 1/125 243/18639 0.00411522633744856 0.61362962962963 0.80715738724925 0.858383774127472 GO:0004676 3-phosphoinositide-dependent protein kinase activity 1/125 245/18639 0.00408163265306122 0.608620408163265 0.809769268097906 0.858383774127472 GO:0004711 ribosomal protein S6 kinase activity 1/125 245/18639 0.00408163265306122 0.608620408163265 0.809769268097906 0.858383774127472 GO:0035175 histone H3S10 kinase activity 1/125 245/18639 0.00408163265306122 0.608620408163265 0.809769268097906 0.858383774127472 GO:0035979 histone H2AXS139 kinase activity 1/125 245/18639 0.00408163265306122 0.608620408163265 0.809769268097906 0.858383774127472 GO:0044022 histone H3S28 kinase activity 1/125 245/18639 0.00408163265306122 0.608620408163265 0.809769268097906 0.858383774127472 GO:0044023 histone H4S1 kinase activity 1/125 245/18639 0.00408163265306122 0.608620408163265 0.809769268097906 0.858383774127472 GO:0044024 histone H2AS1 kinase activity 1/125 245/18639 0.00408163265306122 0.608620408163265 0.809769268097906 0.858383774127472 GO:0044025 histone H2BS14 kinase activity 1/125 245/18639 0.00408163265306122 0.608620408163265 0.809769268097906 0.858383774127472 GO:0072354 histone H3T3 kinase activity 1/125 245/18639 0.00408163265306122 0.608620408163265 0.809769268097906 0.858383774127472 GO:0072371 histone H2AS121 kinase activity 1/125 245/18639 0.00408163265306122 0.608620408163265 0.809769268097906 0.858383774127472 GO:0072518 Rho-dependent protein serine/threonine kinase activity 1/125 245/18639 0.00408163265306122 0.608620408163265 0.809769268097906 0.858383774127472 GO:0140823 histone H2BS36 kinase activity 1/125 245/18639 0.00408163265306122 0.608620408163265 0.809769268097906 0.858383774127472 GO:0140855 histone H3S57 kinase activity 1/125 245/18639 0.00408163265306122 0.608620408163265 0.809769268097906 0.858383774127472 GO:0140995 histone H2A kinase activity 1/125 245/18639 0.00408163265306122 0.608620408163265 0.809769268097906 0.858383774127472 GO:0140997 histone H4 kinase activity 1/125 245/18639 0.00408163265306122 0.608620408163265 0.809769268097906 0.858383774127472 GO:0140998 histone H2B kinase activity 1/125 245/18639 0.00408163265306122 0.608620408163265 0.809769268097906 0.858383774127472 GO:1990244 histone H2AT120 kinase activity 1/125 245/18639 0.00408163265306122 0.608620408163265 0.809769268097906 0.858383774127472 GO:0004677 DNA-dependent protein kinase activity 1/125 246/18639 0.0040650406504065 0.606146341463415 0.811062017988509 0.858383774127472 GO:0140857 histone H3T45 kinase activity 1/125 246/18639 0.0040650406504065 0.606146341463415 0.811062017988509 0.858383774127472 GO:0035402 histone H3T11 kinase activity 1/125 247/18639 0.00404858299595142 0.603692307692308 0.812346052553367 0.858383774127472 GO:0004679 AMP-activated protein kinase activity 1/125 248/18639 0.00403225806451613 0.601258064516129 0.81362143007788 0.858383774127472 GO:0016757 glycosyltransferase activity 1/125 267/18639 0.00374531835205993 0.55847191011236 0.836283522412085 0.879446542923677 GO:0003712 transcription coregulator activity 2/125 495/18639 0.00404040404040404 0.602472727272727 0.848427781556858 0.889348735651241 GO:0015291 secondary active transmembrane transporter activity 1/125 287/18639 0.00348432055749129 0.519554006968641 0.857188786897173 0.895652386309226 GO:0022836 gated channel activity 1/125 318/18639 0.00314465408805031 0.468905660377359 0.884475966885969 0.921211390430754 GO:0003924 GTPase activity 1/125 331/18639 0.00302114803625378 0.450489425981873 0.894316441149095 0.927771691848652 GO:0045296 cadherin binding 1/125 334/18639 0.0029940119760479 0.446443113772455 0.896466512062348 0.927771691848652 GO:0005261 monoatomic cation channel activity 1/125 341/18639 0.00293255131964809 0.437278592375367 0.901316069590836 0.929838730020925 GO:0045182 translation regulator activity 1/125 356/18639 0.00280898876404494 0.41885393258427 0.910962217045146 0.93682549765526 GO:0046982 protein heterodimerization activity 1/125 369/18639 0.002710027100271 0.40409756097561 0.918561688736216 0.941670158893102 GO:0005525 GTP binding 1/125 378/18639 0.00264550264550265 0.39447619047619 0.923442333249043 0.943705958116577 GO:0019001 guanyl nucleotide binding 1/125 400/18639 0.0025 0.37278 0.934185178443863 0.948736349447661 GO:0032561 guanyl ribonucleotide binding 1/125 400/18639 0.0025 0.37278 0.934185178443863 0.948736349447661 GO:0016887 ATP hydrolysis activity 1/125 417/18639 0.00239808153477218 0.35758273381295 0.941449834246244 0.953144863243092 GO:0005216 monoatomic ion channel activity 1/125 448/18639 0.00223214285714286 0.332839285714286 0.952709014983532 0.95849533458797 GO:0046873 metal ion transmembrane transporter activity 1/125 450/18639 0.00222222222222222 0.33136 0.953356722576476 0.95849533458797 GO:0022804 active transmembrane transporter activity 1/125 457/18639 0.00218818380743982 0.326284463894967 0.95555516484997 0.95849533458797 GO:0005543 phospholipid binding 1/125 497/18639 0.00201207243460765 0.300024144869215 0.966282922613059 0.966282922613059