category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
NA	NA	hsa04517	IgSF CAM signaling	24/300	299/9376	2.50862876254181	NRP1/KCNQ3/SRGAP3/TJP1/JAML/CASK/UNC5C/MTSS1/ANK2/CD28/EPB41L1/EPB41L3/CABLES1/CNTNAP2/EPB41L2/PLXNA4/NCK2/PRKCB/CD209/RASA1/PMP22/INPP5D/BAIAP2/NRP2	4.81998661073562
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	19/300	250/9376	2.37525333333333	WWP1/ASAP1/PLD1/EPS15/IL2RA/DNM1/RABEP1/CAPZB/SNX2/DAB2/PSD3/GRK3/IGF1R/FOLR2/RAB11A/CYTH4/WASHC3/ZFYVE16/ITCH	4.00692764586641
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	11/300	105/9376	3.27415873015873	EDA/BLNK/EDARADD/CXCL12/PRKCB/TRAF3/TAB2/SYK/TNFRSF1A/TNFSF13B/ATM	4.26040764128494
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	18/300	250/9376	2.25024	LGMN/OSBPL3/MCOLN1/GPR155/TPCN1/CTSC/OSBPL1A/OSBPL6/ATP6V1C1/NCOA7/AP3B1/FIG4/DMXL2/ASAH1/MITF/DMXL1/GNPTAB/DTNBP1	3.6426897492593
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	9/300	93/9376	3.02451612903226	RBPJ/IL2RA/IL12RB2/HLA-DMA/JAK2/HLA-DRB1/HLA-DMB/NOTCH2/NFATC2	3.56711870701653
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	8/300	78/9376	3.20547008547009	CR1/FCGR2A/HLA-DMA/PRKCB/JAK2/HLA-DRB1/TAB2/HLA-DMB	3.55592607590832
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	4/300	21/9376	5.95301587301587	BCAT1/VNN2/VNN1/PPCDC	4.1310123484826
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	14/300	200/9376	2.18773333333333	NAIP/TJP1/MYO1D/FCGR2A/MYO5A/NCK2/TAB2/RAB1A/CYTH4/MYO5B/TNFRSF1A/TNFSF10/BAIAP2/ARHGEF11	3.08678415524469
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	6/300	50/9376	3.7504	CD28/HLA-DMA/CXCL12/HLA-DRB1/HLA-DMB/TNFSF13B	3.5451301020788
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	11/300	142/9376	2.42103286384977	ITPR2/FCGR2A/FCGR2B/BLNK/TAB2/SYK/CALCR/LILRB4/MITF/TNFRSF1A/NFATC2	3.10207562280311
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	7/300	70/9376	3.12533333333333	DTNA/CD28/HLA-DMA/DMD/HLA-DRB1/HLA-DMB/SGCD	3.24484212577606
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	9/300	109/9376	2.5805504587156	IL2RA/HIF1A/HLA-DMA/IL21R/RORA/JAK2/HLA-DRB1/HLA-DMB/NFATC2	3.0175262345185
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	8/300	91/9376	2.74754578754579	FCGR2B/BLNK/PRKCB/SYK/LILRB4/INPP5D/SOS1/NFATC2	3.04549105048757
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	8/300	98/9376	2.5512925170068	ASAP1/PLD1/FCGR2A/FCGR2B/PRKCB/SYK/PLA2G4C/INPP5D	2.80658741390554
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	7/300	80/9376	2.73466666666667	IGF1/FOXO3/IGF1R/PRKCB/JAK2/GAB1/SOS1	2.83277441357256
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	5/300	45/9376	3.47259259259259	ABCA1/ABCA6/ABCA8/CFTR/ABCA9	3.02269096561236
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	10/300	142/9376	2.20093896713615	WWP1/BIRC7/PRKN/MGRN1/COP1/PIAS2/MAP3K1/HERC1/UBE2E1/ITCH	2.62161670514417
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	3/300	17/9376	5.51529411764706	PCDH7/CD209/NRP2	3.38762090076038
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	6/300	66/9376	2.84121212121212	IL12RB2/HLA-DMA/IL21R/RORA/HLA-DRB1/HLA-DMB	2.72897762286507
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	4/300	34/9376	3.67686274509804	PER3/CRY1/RORA/PER2	2.8427891715628
Human Diseases	Substance dependence	hsa05032	Morphine addiction	7/300	91/9376	2.40410256410256	PDE4D/GNG2/KCNJ5/GRK3/PRKCB/PDE8A/PDE1A	2.44696409296741
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	10/300	155/9376	2.01634408602151	STX7/COLEC12/FCGR2A/FCGR2B/HLA-DMA/CD209/ATP6V1C1/HLA-DRB1/SCARB1/HLA-DMB	2.31961882393864
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	3/300	21/9376	4.4647619047619	CSGALNACT1/CHSY1/CHST15	2.88974931235348
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	7/300	93/9376	2.35240143369176	PLD1/ITPR2/MMP2/PRKCB/PLA2G4C/MAP3K1/SOS1	2.38287874536413
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	4/300	37/9376	3.37873873873874	HBB/HBA2/HBA1/PRKCB	2.63570282207369
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	7/300	95/9376	2.30287719298246	CD28/HLA-DMA/CXCL12/ATP6V1C1/HLA-DRB1/HLA-DMB/TNFSF13B	2.32042170965588
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	8/300	116/9376	2.15540229885057	PLD1/GNG2/ITPR2/GRK3/PRKCB/GRIK1/PLA2G4C/GRIK2	2.27643760144091
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	5/300	56/9376	2.79047619047619	MAN1A1/MGAT1/ST6GAL1/MAN1C1/MGAT4A	2.44316967644923
Human Diseases	Immune disease	hsa05330	Allograft rejection	4/300	39/9376	3.20547008547009	CD28/HLA-DMA/HLA-DRB1/HLA-DMB	2.50916266901795
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	7/300	99/9376	2.20983164983165	IGF1/ITPR2/HRH1/HTR2B/TRPV4/PRKCB/PLA2G4C	2.20007650244103
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	7/300	99/9376	2.20983164983165	IGF1/TTN/DTNA/DMD/SGCD/CACNB2/CACNA2D3	2.20007650244103
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	3/300	24/9376	3.90666666666667	HS3ST2/HS6ST1/HS2ST1	2.59207536131387
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	8/300	122/9376	2.04939890710383	TBC1D4/HIF1A/THRB/NCOA1/MED13L/PRKCB/SLC16A10/NOTCH2	2.12106900291436
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	13/300	238/9376	1.70711484593838	PLD1/IGF1/GNG2/RGL1/IGF1R/PRKCB/RASA1/PLA2G4C/GAB1/RALGAPA1/RASAL2/RALGAPA2/SOS1	2.00887021209516
Organismal Systems	Nervous system	hsa04730	Long-term depression	5/300	60/9376	2.60444444444444	IGF1/ITPR2/IGF1R/PRKCB/PLA2G4C	2.26665065957075
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	7/300	105/9376	2.08355555555556	IGF1/TTN/DTNA/DMD/SGCD/CACNB2/CACNA2D3	2.02993234703693
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	4/300	44/9376	2.84121212121212	MAN1A1/MGAT1/MAN1C1/MGAT4A	2.22557287958243
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	4/300	44/9376	2.84121212121212	CD28/HLA-DMA/HLA-DRB1/HLA-DMB	2.22557287958243
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/300	12/9376	5.20888888888889	FCGR2B/CD209	2.6523229511675
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	4/300	45/9376	2.77807407407407	CD28/HLA-DMA/HLA-DRB1/HLA-DMB	2.17365709821927
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	6/300	86/9376	2.18046511627907	DTNA/DMD/TCF7L2/SGCD/CACNB2/CACNA2D3	1.99937173592567
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	15/300	300/9376	1.56266666666667	IGF1/MEF2C/MKNK1/RPS6KA3/IGF1R/PRKCB/TAB2/RASA1/MAP2K5/PLA2G4C/MAP3K1/CACNB2/CACNA2D3/TNFRSF1A/SOS1	1.80079216846577
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	9/300	154/9376	1.82649350649351	MEF2C/ITPR2/KCNJ5/PRKCB/MAP2K5/PLA2G4C/CACNB2/CACNA2D3/NFATC2	1.8801230300882
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	10/300	181/9376	1.72670349907919	CR1/FCGR2A/FCGR2B/HLA-DMA/CD209/JAK2/HLA-DRB1/SYK/HLA-DMB/TNFRSF1A	1.79481501436552
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	6/300	89/9376	2.10696629213483	TJP1/ITPR2/HTR2B/PRKCB/MAP2K5/SOS1	1.9076148695212
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	7/300	112/9376	1.95333333333333	BIRC7/HLA-DMA/JAK2/HLA-DRB1/TAB2/HLA-DMB/TNFRSF1A	1.84524288110257
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	4/300	50/9376	2.50026666666667	HBB/HBA2/CR1/HBA1	1.93376982298772
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	7/300	115/9376	1.9023768115942	PDE4D/PLD1/MEF2C/ITPR2/AKAP13/PRKCB/ARHGEF11	1.77013719070305
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	10/300	187/9376	1.67130124777184	NAIP/PKN2/IFI16/ANTXR1/ITPR2/ERBIN/TRAF3/TAB2/TANK/P2RX7	1.6857887601236
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	4/300	51/9376	2.45124183006536	PLD1/ENPP2/CEPT1/PLA2G4C	1.88929370530892
Human Diseases	Immune disease	hsa05310	Asthma	3/300	32/9376	2.93	HLA-DMA/HLA-DRB1/HLA-DMB	1.98822213830137
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	4/300	52/9376	2.40410256410256	IGF1/IGF1R/SCARB1/PLA2G4C	1.84585844901614
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	11/300	216/9376	1.5916049382716	ABCA1/POU2F2/TRAF3/JAK2/TAB2/TANK/ATF6/TNFRSF1A/TNFSF10/NFE2L2/NFATC2	1.59922640258814
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4/300	53/9376	2.35874213836478	DNM1/PRKCB/RAB11A/ATP2B1	1.80341699865087
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	9/300	168/9376	1.67428571428571	IL2RA/IL12RB2/IL7/IL21R/JAK2/PTPN2/PRLR/PIAS2/SOS1	1.60330064072339
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	9/300	169/9376	1.66437869822485	ATG7/STX7/HIF1A/WDFY3/IGF1R/DAPK1/UVRAG/RAB1A/TANK	1.58452465823937
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	4/300	54/9376	2.31506172839506	CD28/HLA-DMA/HLA-DRB1/HLA-DMB	1.76192529872614
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	10/300	196/9376	1.59455782312925	HIF1A/GNG2/ITPR2/CD200R1/TRAF3/JAK2/SYK/TCF7L2/TNFRSF1A/NFATC2	1.52932509466751
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	4/300	55/9376	2.2729696969697	ACER3/UGCG/SGMS1/ASAH1	1.72134205007722
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	6/300	100/9376	1.8752	CR1/IL2RA/HLA-DMA/IL7/HLA-DRB1/HLA-DMB	1.5996536487626
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	9/300	173/9376	1.62589595375723	HLA-DMA/PRKCB/TRAF3/JAK2/HLA-DRB1/RAB11A/HLA-DMB/TNFRSF1A/TNFSF10	1.51063487408109
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	8/300	149/9376	1.67803131991051	LPAR6/PLD1/DNM1/SYK/PLA2G4C/GAB1/CYTH4/SOS1	1.51674178468288
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/300	36/9376	2.60444444444444	AKR1A1/CRYL1/UGP2	1.75348283146826
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	10/300	201/9376	1.55489220563847	IGF1/MEF2C/PAX8/FLI1/NUPR1/MLLT3/IGF1R/PER2/MITF/ATM	1.44578141812986
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	6/300	105/9376	1.78590476190476	HIF1A/PRKN/FOXO3/BNIP3L/TBC1D17/MITF	1.47231352347493
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	3/300	38/9376	2.46736842105263	IGF1/PRKCB/NR3C2	1.64779451896793
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	9/300	180/9376	1.56266666666667	HLA-DMA/POU2F2/TRAF3/JAK2/HLA-DRB1/TAB2/SYK/HLA-DMB/TNFRSF1A	1.38575668000872
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	8/300	157/9376	1.59252653927813	ABCA1/HIF1A/P2RY6/VPS8/ATP8A1/JAK2/NFATC2/PPARD	1.36117745664892
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/300	20/9376	3.12533333333333	NPL/UGP2	1.72980029519391
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	6/300	110/9376	1.70472727272727	IGF1/HIF1A/MKNK1/IGF1R/PRKCB/PDK1	1.35166881932769
Human Diseases	Infectious disease: viral	hsa05162	Measles	7/300	136/9376	1.60862745098039	IL2RA/FCGR2B/CD28/RAB9A/CD209/TRAF3/TAB2	1.29982243014061
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	4/300	65/9376	1.92328205128205	SPP1/ITPR2/KCNJ5/PRKCB	1.35797548496101
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/300	22/9376	2.84121212121212	HNMT/AOC1	1.57186594490833
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	5/300	89/9376	1.75580524344569	GNG2/PRKCB/NSF/PLCL1/ABAT	1.30246542383739
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	13/300	298/9376	1.36340044742729	TNFRSF25/IL2RA/EDA/IL12RB2/CXCL12/IL7/IL21R/BMPR1A/PRLR/TNFRSF4/TNFRSF1A/TNFSF10/TNFSF13B	1.15903759322547
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	6/300	115/9376	1.63060869565217	GNG2/ITPR2/KCNJ5/HTR2B/PRKCB/PLA2G4C	1.23702636261517
NA	NA	hsa04081	Hormone signaling	10/300	219/9376	1.42709284627093	IGF1/THRB/GNG2/IGF1R/SLC16A10/JAK2/BMPR1A/CALCR/PRLR/APPL1	1.16269758233442
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	7/300	142/9376	1.54065727699531	MEF2C/MMP2/TRPV4/BMPR1A/MAP2K5/TNFRSF1A/NFE2L2	1.18023995216733
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	4/300	68/9376	1.83843137254902	TCF7L2/PER2/SOS1/PPARD	1.26151614037515
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	5/300	93/9376	1.68028673835125	TJP1/IGF1R/FER/TCF7L2/BAIAP2	1.19863878371174
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	8/300	170/9376	1.47074509803922	ARID1B/IGF1R/PRKCB/TCF7L2/GAB1/SMARCA2/SOS1/NFE2L2	1.12609181984447
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	4/300	69/9376	1.81178743961353	SYK/PLA2G4C/INPP5D/SOS1	1.23044169068157
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	4/300	70/9376	1.78590476190476	JAK2/TNFRSF1A/APPL1/PPARA	1.19987619743252
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	6/300	120/9376	1.56266666666667	FOXO3/RPS6KA3/MAP2K5/GAB1/MAP3K1/SOS1	1.12779238948074
NA	NA	hsa04082	Neuroactive ligand signaling	9/300	199/9376	1.41346733668342	P2RY14/GNG2/HRH1/P2RY6/HTR2B/PRKCB/GRIK1/TAC3/GRIK2	1.07180653556901
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	3/300	47/9376	1.99489361702128	AKR1A1/ME1/ACSS1	1.24310281220661
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	4/300	71/9376	1.76075117370892	FOXO3/JAK2/PRLR/SOS1	1.16980275181537
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	6/300	122/9376	1.53704918032787	IGF1/ITPR2/PRKCB/JAK2/MAP3K1/SOS1	1.08549605085619
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	3/300	48/9376	1.95333333333333	IL4I1/BCAT1/ABAT	1.20384382753053
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	5/300	97/9376	1.61099656357388	PER3/GNG2/KCNJ5/PRKCB/PER2	1.09969707364303
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	5/300	98/9376	1.59455782312925	ITPR2/PRKCB/PIP4P2/INPP5D/IPMK	1.07566979466472
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	5/300	98/9376	1.59455782312925	ITPR2/KCNJ5/PRKCB/SCARB1/ATP2B1	1.07566979466472
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	4/300	73/9376	1.71251141552511	FHIT/FOXO3/PRKCB/SOS1	1.11106832932541
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	3/300	49/9376	1.9134693877551	ST6GAL1/COLGALT2/GALNT17	1.16552091546844
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	9/300	204/9376	1.37882352941176	IGF1/HIF1A/ITPR2/ANK2/MMP2/IGF1R/PRKCB/GAB1/SOS1	0.994532611660462
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	5/300	99/9376	1.57845117845118	IGF1/MMP2/IGF1R/NOTCH2/SOS1	1.05191234309075
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	5/300	99/9376	1.57845117845118	FCGR2A/FCGR2B/HLA-DMA/HLA-DRB1/HLA-DMB	1.05191234309075
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	5/300	99/9376	1.57845117845118	PLD1/HIF1A/PRKCB/PLA2G4C/SOS1	1.05191234309075
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	3/300	51/9376	1.83843137254902	TJP1/ATP6V1C1/CFTR	1.09150872147824
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	4/300	76/9376	1.64491228070175	ME1/GK/PPARA/PPARD	1.02627793309737
Human Diseases	Cancer: specific types	hsa05214	Glioma	4/300	76/9376	1.64491228070175	IGF1/IGF1R/PRKCB/SOS1	1.02627793309737
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	5/300	102/9376	1.53202614379085	ITPR2/PRKCB/CFTR/RAB11A/ATP2B1	0.982196848083047
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	8/300	184/9376	1.35884057971014	NRP1/SRGAP3/UNC5C/CXCL12/PLXNA4/NCK2/RASA1/NFATC2	0.893726170288958
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	7/300	158/9376	1.38464135021097	IGF1/RPS6KA3/IGF1R/PRKCB/ATP6V1C1/TNFRSF1A/SOS1	0.886472329558627
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	4/300	79/9376	1.58244725738397	DNM1/SYT1/ATP6V1C1/NSF	0.945143510455802
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	5/300	106/9376	1.47421383647799	IGF1/IGF1R/FOLR2/TCF7L2/SOS1	0.892660482084925
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	6/300	133/9376	1.40992481203008	IGF1/FOXO3/IGF1R/TNFSF10/SOS1/ATM	0.865610612124149
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	3/300	56/9376	1.67428571428571	CR1/NAIP/RAB1A	0.920087303684071
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	7/300	163/9376	1.34216768916155	PRKCB/TRAF3/JAK2/TAB2/MAP3K1/SOS1/NFATC2	0.801182187868368
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	4/300	82/9376	1.52455284552846	LGMN/HLA-DMA/HLA-DRB1/HLA-DMB	0.867348958544437
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	5/300	109/9376	1.43363914373089	TBC1D4/RPS6KA3/PRKCB/TNFRSF1A/PPARA	0.827887199239073
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	2/300	32/9376	1.95333333333333	ACSS1/ABAT	0.982092455188587
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/300	32/9376	1.95333333333333	BIRC7/TNFRSF1A	0.982092455188587
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	6/300	137/9376	1.36875912408759	ITPR2/CTSC/NOL3/TNFRSF1A/TNFSF10/ATM	0.790477652772587
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	5/300	110/9376	1.42060606060606	IGF1/SPDYE16/SPDYE1/RPS6KA3/IGF1R	0.806723564339021
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/300	10/9376	3.12533333333333	SELENBP1	1.22250036904314
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	6/300	138/9376	1.35884057971014	IGF1/ITPR2/SPDYE16/SPDYE1/RPS6KA3/IGF1R	0.772060148135297
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	6/300	138/9376	1.35884057971014	PKN2/FCGR2A/RPS6KA3/TAB2/BAIAP2/NFATC2	0.772060148135297
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	6/300	139/9376	1.34906474820144	ITPR2/KCNJ5/NCOA1/GREB1/MMP2/SOS1	0.753784047620641
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	9/300	224/9376	1.25571428571429	NRP1/IL2RA/HLA-DMA/HLA-DRB1/HLA-DMB/MAP3K1/TNFRSF1A/NFATC2/ATM	0.704238909514858
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	3/300	59/9376	1.58915254237288	FOXO3/TCF7L2/SOS1	0.825305493957987
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	10/300	254/9376	1.23044619422572	MCOLN1/ITPR2/HRH1/TPCN1/HTR2B/PRKCB/P2RX7/ATP2B1/PDE1A/NFATC2	0.676924739558352
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	4/300	86/9376	1.45364341085271	NCK2/PRKCB/GAB1/SOS1	0.7683427501075
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	3/300	60/9376	1.56266666666667	PRKCB/PLA2G4C/NFATC2	0.794897433522596
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	9/300	227/9376	1.23911894273128	GNG2/ITPR2/CXCL12/AKAP13/PRKCB/TNFRSF1A/SOS1/NFATC2/ARHGEF11	0.663039067418232
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	5/300	115/9376	1.35884057971014	KCNQ3/GNG2/ITPR2/PRKCB/JAK2	0.703915534527294
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	6/300	144/9376	1.30222222222222	FOXO3/TRAF3/TAB2/TCF7L2/TNFRSF1A/PPARA	0.664444582354532
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	3/300	62/9376	1.51225806451613	IGF1/FOXO3/IGF1R	0.735725068614954
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	3/300	62/9376	1.51225806451613	RBPJ/NOTCH2/ITCH	0.735725068614954
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/300	36/9376	1.7362962962963	GBE1/UGP2	0.804691567165027
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	4/300	90/9376	1.38903703703704	IGF1/FOXO3/IGF1R/APPL1	0.674212633177558
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	4/300	90/9376	1.38903703703704	HIF1A/CD28/JAK2/NFATC2	0.674212633177558
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	9/300	233/9376	1.20721030042918	TTN/DAAM2/DTNA/CAPZB/ANK2/DMD/ACTG2/SGCD/DIAPH2	0.582296209414534
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/300	37/9376	1.68936936936937	IL4I1/ABAT	0.763838736347064
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	2/300	37/9376	1.68936936936937	PAX8/TCF7L2	0.763838736347064
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	5/300	119/9376	1.31316526610644	TRAF3/RHBDF2/TAB2/TNFRSF1A/ITCH	0.625044529090443
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	8/300	205/9376	1.21964227642276	RBPJ/BLNK/HLA-DMA/TRAF3/HLA-DRB1/TAB2/SYK/HLA-DMB	0.578074140252946
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	6/300	148/9376	1.26702702702703	IGF1/NCOA1/IGF1R/TCF7L2/NOTCH2/SOS1	0.595293728530343
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	7/300	178/9376	1.22906367041199	DAAM2/ROR1/PRKCB/TCF7L2/NFATC2/PPARD/MCC	0.560942745586514
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	2/300	38/9376	1.64491228070175	RENBP/UGP2	0.724210025313979
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	3/300	65/9376	1.44246153846154	ITPR2/SCARB1/PDE8A	0.650778298391668
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	9/300	238/9376	1.1818487394958	F13A1/NRP1/RPL10/FCGR2A/PRKCB/TRAF3/TAB2/SYK/TNFRSF1A	0.516621193825138
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	3/300	67/9376	1.39940298507463	AKR1A1/ACSS1/BPGM	0.596480450777288
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	3/300	67/9376	1.39940298507463	ITPR2/RPS6KA3/PRKCB	0.596480450777288
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	5/300	125/9376	1.25013333333333	PLD1/SGMS1/PRKCB/ASAH1/TNFRSF1A	0.511836506645433
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	13/300	362/9376	1.12235727440147	SPP1/LPAR6/IGF1/IL2RA/PKN2/GNG2/FOXO3/IL7/IGF1R/JAK2/SYK/PRLR/SOS1	0.43164262454445
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	2/300	41/9376	1.52455284552846	MMP2/DAPK1	0.611960000691106
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	3/300	70/9376	1.33942857142857	HIF1A/GAB1/SOS1	0.518220887984669
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/300	42/9376	1.48825396825397	IL4I1/AOC1	0.576548107013763
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	4/300	100/9376	1.25013333333333	IL2RA/CXCL12/TNFRSF1A/TNFSF10	0.457183157385534
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/300	43/9376	1.45364341085271	ABCA1/SCARB1	0.542047348041246
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	13/300	370/9376	1.09809009009009	LPAR6/P2RY14/THRB/HRH1/P2RY6/HTR2B/GRIK1/CALCR/P2RX7/PRLR/NR3C1/TAC3/GRIK2	0.349992748327624
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	6/300	160/9376	1.172	JAML/CD28/HLA-DMA/CNTNAP2/HLA-DRB1/HLA-DMB	0.398947940228774
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/300	16/9376	1.95333333333333	IL4I1	0.693850438867467
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	3/300	72/9376	1.30222222222222	TRAF3/TANK/MAP3K1	0.468011811646539
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	2/300	44/9376	1.42060606060606	MNAT1/GTF2F2	0.508409341155434
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	2/300	44/9376	1.42060606060606	NSF/RAB11A	0.508409341155434
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	3/300	73/9376	1.28438356164384	SERINC5/MLLT3/RANBP2	0.443458956359821
Human Diseases	Cancer: specific types	hsa05218	Melanoma	3/300	73/9376	1.28438356164384	IGF1/IGF1R/MITF	0.443458956359821
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	5/300	133/9376	1.1749373433584	PRKCB/SYK/TNFSF10/SOS1/NFATC2	0.36940340380451
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	7/300	193/9376	1.13354058721934	GNG2/FOXO3/CXCL12/GRK3/PRKCB/JAK2/SOS1	0.340799277926448
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/300	17/9376	1.83843137254902	HSD17B4	0.629037127481821
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	4/300	104/9376	1.20205128205128	PLD1/SGMS1/CEPT1/PLA2G4C	0.376695637418381
Cellular Processes	Cell motility	hsa04814	Motor proteins	7/300	194/9376	1.12769759450172	MYO1D/CAPZB/DNAH11/MYO5A/ACTG2/MYO5B/MYO9B	0.326748768212517
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	5/300	134/9376	1.16616915422886	ITPR2/PRKCB/ACTG2/PLA2G4C/ARHGEF11	0.352223921849472
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	3/300	75/9376	1.25013333333333	IGF1/COP1/ATM	0.395399760677046
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	3/300	75/9376	1.25013333333333	PAX8/ITPR2/PRKCB	0.395399760677046
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	4/300	105/9376	1.19060317460317	ITPR2/CD209/SYK/NFATC2	0.357075876350924
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	3/300	76/9376	1.23368421052632	ITPR2/PRKCB/CFTR	0.371872199914499
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	3/300	78/9376	1.20205128205128	FIG4/INPP5D/IPMK	0.325771556481447
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	2/300	50/9376	1.25013333333333	P4HA1/AOC1	0.322409543896637
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	5/300	143/9376	1.09277389277389	FCGR2A/CD28/HLA-DMA/HLA-DRB1/HLA-DMB	0.203245717152542
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	6/300	174/9376	1.07770114942529	MAN1A1/PRKN/MAN1C1/ERO1B/ATF6/NFE2L2	0.188087517745027
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	5/300	144/9376	1.08518518518519	IGF1/IGF1R/JAK2/BMPR1A/ZFHX3	0.187282173947969
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	5/300	144/9376	1.08518518518519	RBPJ/ITPR2/PRKCB/RORA/PUM2	0.187282173947969
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	3/300	83/9376	1.12963855421687	AUTS2/SCML1/PHC3	0.215672254663159
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	2/300	52/9376	1.20205128205128	ABCA1/SCARB1	0.265620244306924
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	4/300	116/9376	1.07770114942529	CXCL12/MMP2/PRKCB/TXK	0.15309110809531
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	2/300	54/9376	1.15753086419753	IL4I1/BCAT1	0.211060522077972
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	5/300	149/9376	1.04876957494407	GNG2/ITPR2/KCNJ5/PRKCB/NDUFB9	0.109096512162091
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/300	23/9376	1.35884057971014	LARGE1	0.313248516128847
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/300	23/9376	1.35884057971014	NLN	0.313248516128847
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	3/300	87/9376	1.07770114942529	TCF7L2/SOS1/APPL1	0.132373670153124
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	7/300	214/9376	1.02230529595016	GNG2/ITPR2/PRKCB/TAB2/TNFRSF1A/NFATC2/ATM	0.0600093268060977
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	3/300	88/9376	1.06545454545455	F13A1/CR1/A2M	0.112155110073404
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	2/300	56/9376	1.11619047619048	GRK3/MGRN1	0.158546117301492
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	5/300	154/9376	1.01471861471861	AKR1A1/DHRS3/BCAT1/UGP2/PPCDC	0.0334821826016127
NA	NA	hsa04518	Integrin signaling	5/300	154/9376	1.01471861471861	SPP1/IGF1/ITGAD/IGF1R/NCK2	0.0334821826016127
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	4/300	122/9376	1.02469945355191	IGF1/FOXO3/IGF1R/CFTR	0.0499230987980261
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	4/300	122/9376	1.02469945355191	CD28/NCK2/SOS1/NFATC2	0.0499230987980261
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	5/300	156/9376	1.0017094017094	TRAF3/SCARB1/TNFRSF1A/SOS1/PPARA	0.00391417279878636
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	8/300	253/9376	0.988247694334651	NAIP/ITPR2/FOXO3/TAB2/CYTH4/TNFRSF1A/U2AF1/ATM	-0.0344519274179833
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	5/300	157/9376	0.995329087048832	ITPR2/FOXO3/TRPV4/NFATC2/ATM	-0.0107302221751027
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/300	26/9376	1.20205128205128	PLA2G4C	0.187560551458685
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/300	26/9376	1.20205128205128	SCARB1	0.187560551458685
Organismal Systems	Digestive system	hsa04970	Salivary secretion	3/300	93/9376	1.00817204301075	ITPR2/PRKCB/ATP2B1	0.0143988220593401
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	3/300	93/9376	1.00817204301075	FHIT/BIRC7/TRAF3	0.0143988220593401
Organismal Systems	Immune system	hsa04611	Platelet activation	4/300	126/9376	0.992169312169312	ITPR2/FCGR2A/SYK/PLA2G4C	-0.0160884179273977
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/300	27/9376	1.15753086419753	ABAT	0.149026663959014
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/300	27/9376	1.15753086419753	HSD17B4	0.149026663959014
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	4/300	128/9376	0.976666666666667	PDE4D/FHIT/PDE8A/PDE1A	-0.0483233330379724
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	7/300	227/9376	0.963759177679883	PLD1/HIF1A/FOXO3/AKR1A1/NDUFB9/SOS1/NFE2L2	-0.100490077277585
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	6/300	195/9376	0.961641025641026	CR1/ATG7/HDAC9/FCGR2A/PRKCB/SYK	-0.098409793486974
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/300	28/9376	1.11619047619048	ATP6V1C1	0.111941009049213
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	2/300	63/9376	0.992169312169312	COLGALT2/KMT2C	-0.0113376855169141
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/300	29/9376	1.07770114942529	LIMD1	0.0761884858985648
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/300	29/9376	1.07770114942529	CNGA1	0.0761884858985648
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	5/300	166/9376	0.94136546184739	MEF2C/ITPR2/CNGA1/ATP2B1/NFATC2	-0.138572406631526
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	4/300	133/9376	0.939949874686717	GNG2/ITPR2/KCNJ5/PRKCB	-0.12680380451513
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	2/300	65/9376	0.961641025641026	AKR1A1/GK	-0.0564188881776735
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/300	30/9376	1.04177777777778	PIGX	0.0416669869353107
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/300	30/9376	1.04177777777778	PLA2G4C	0.0416669869353107
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/300	30/9376	1.04177777777778	FOLR2	0.0416669869353107
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	10/300	333/9376	0.938538538538539	RBPJ/SPP1/ATP6V1C1/TRAF3/TCF7L2/NOTCH2/TNFRSF1A/SOS1/ATM/DLG2	-0.207619316129727
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	3/300	101/9376	0.928316831683168	PRKCB/TCF7L2/MITF	-0.131680037672349
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	3/300	101/9376	0.928316831683168	MMP2/PRKCB/JAK2	-0.131680037672349
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/300	31/9376	1.00817204301075	AKR1A1	0.00828554079073287
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/300	31/9376	1.00817204301075	ABAT	0.00828554079073287
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/300	31/9376	1.00817204301075	ACSS1	0.00828554079073287
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/300	31/9376	1.00817204301075	IMMP2L	0.00828554079073287
NA	NA	hsa04981	Folate transport and metabolism	1/300	31/9376	1.00817204301075	FOLR2	0.00828554079073287
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	6/300	203/9376	0.923743842364532	SPP1/IGF1/IGF1R/PRKCB/EMP2/SOS1	-0.199694573075221
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/300	68/9376	0.91921568627451	DHRS3/ALDH1A1	-0.121549263291525
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	6/300	205/9376	0.914731707317073	TBC1D4/PDK3/MMP2/PRKCB/NDUFB9/PPARA	-0.224416700583835
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/300	32/9376	0.976666666666667	UGP2	-0.0240372279241961
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/300	32/9376	0.976666666666667	ATG7	-0.0240372279241961
Organismal Systems	Endocrine system	hsa04924	Renin secretion	2/300	69/9376	0.905893719806763	ITPR2/PDE1A	-0.142638682066633
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/300	33/9376	0.947070707070707	BCAT1	-0.0553743842306273
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/300	33/9376	0.947070707070707	STX7	-0.0553743842306273
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	4/300	140/9376	0.892952380952381	SPP1/MEF2C/GNG2/ITPR2	-0.232005398120213
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	2/300	71/9376	0.88037558685446	TJP1/ATP6V1C1	-0.183945779537495
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	2/300	71/9376	0.88037558685446	HIF1A/PDK1	-0.183945779537495
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	3/300	109/9376	0.860183486238532	SPP1/TRAF3/TAB2	-0.266932318400638
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	7/300	248/9376	0.882150537634409	NAIP/RAB9A/TAB2/TCF7L2/CYTH4/TNFRSF1A/TNFSF10	-0.341951609532935
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/300	36/9376	0.868148148148148	GALNT17	-0.144099697138204
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	6/300	217/9376	0.864147465437788	RPS6KA3/PRKCB/JAK2/NOTCH2/SOS1/PPARA	-0.368105752801611
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/300	37/9376	0.844684684684685	IL4I1	-0.172093306516249
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/300	37/9376	0.844684684684685	UGP2	-0.172093306516249
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/300	38/9376	0.822456140350877	BLNK	-0.199374468339975
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	2/300	78/9376	0.801367521367521	DNM1/GAB1	-0.320259347403927
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	6/300	226/9376	0.829734513274336	PDE4D/PLD1/CFTR/CNGA1/ATP2B1/PPARA	-0.471052506139436
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	4/300	155/9376	0.806537634408602	ITPR2/SCARB1/TCF7L2/PDE8A	-0.441542338979095
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/300	41/9376	0.762276422764228	BPGM	-0.277335871360941
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	1/300	41/9376	0.762276422764228	ATM	-0.277335871360941
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	4/300	157/9376	0.796263269639066	LIMD1/BMPR1A/TCF7L2/DLG2	-0.468032781783111
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	4/300	157/9376	0.796263269639066	NDUFB9/TNFRSF1A/PPARA/ITCH	-0.468032781783111
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	1/300	42/9376	0.744126984126984	ATG7	-0.302144196523468
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	4/300	158/9376	0.791223628691983	STAG1/NIPBL/ATM/TFDP2	-0.481161154745073
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	6/300	232/9376	0.808275862068966	IQGAP2/CXCL12/ITGAD/DIAPH2/BAIAP2/SOS1	-0.5375906409722
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/300	86/9376	0.726821705426357	SCN9A/PDE1A	-0.462686235710668
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	2/300	87/9376	0.718467432950192	CACNB2/CACNA2D3	-0.479626098759937
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/300	46/9376	0.679420289855072	BLVRB	-0.396253533364686
Organismal Systems	Digestive system	hsa04976	Bile secretion	2/300	90/9376	0.694518518518519	CFTR/SCARB1	-0.529408396653513
NA	NA	hsa03272	Virion - Hepatitis viruses	1/300	48/9376	0.651111111111111	SCARB1	-0.440567554597419
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/300	48/9376	0.651111111111111	PRKCB	-0.440567554597419
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	4/300	168/9376	0.744126984126984	JAK2/PLA2G4C/TNFRSF1A/TNFSF10	-0.60840881187526
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	3/300	130/9376	0.721230769230769	GNG2/MMP2/SOS1	-0.581886913675826
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	4/300	170/9376	0.735372549019608	TJP1/CFTR/MAP3K1/DLG2	-0.633027957373414
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	2/300	94/9376	0.664964539007092	TRAF3/TAB2	-0.593516699494218
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	3/300	138/9376	0.679420289855072	PRKAR1A/MKNK1/SOS1	-0.689740326201646
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	9/300	368/9376	0.764347826086957	PRKN/DNAH11/NDUFB9/RAB1A/TANK/FIG4/ATF6/RANBP2/TNFRSF1A	-0.838455838150772
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/300	57/9376	0.548304093567251	HSD17B4	-0.621867626440075
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	2/300	107/9376	0.58417445482866	ITPR2/PPARA	-0.786476291572452
Organismal Systems	Digestive system	hsa04978	Mineral absorption	1/300	61/9376	0.512349726775956	ATP2B1	-0.694673899480743
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	3/300	150/9376	0.625066666666667	TCF7L2/GAB1/SOS1	-0.841573359734925
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	2/300	108/9376	0.578765432098765	RANBP17/RANBP2	-0.800464158478886
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	2/300	110/9376	0.568242424242424	BMPR1A/ZFYVE16	-0.828112200626972
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	1/300	63/9376	0.496084656084656	PLA2G4C	-0.72959538421006
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/300	63/9376	0.496084656084656	MNAT1	-0.72959538421006
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	1/300	63/9376	0.496084656084656	TCF7L2	-0.72959538421006
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	3/300	154/9376	0.608831168831169	ATP2B1/CACNB2/CACNA2D3	-0.889838241141682
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	5/300	235/9376	0.664964539007092	ARID1B/RPS6KA3/NDUFB9/SMARCA2/SOS1	-0.945642265788536
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	2/300	116/9376	0.538850574712644	ME1/ACSS1	-0.908582138577488
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	2/300	117/9376	0.534245014245014	ARID1B/SMARCA2	-0.921652962411416
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	1/300	69/9376	0.452946859903382	PRKCB	-0.829178868440734
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	4/300	205/9376	0.609821138211382	RBPJ/HDAC9/TRAF3/SYK	-1.02690754142062
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	1/300	75/9376	0.416711111111111	BCAT1	-0.922037395011648
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	1/300	75/9376	0.416711111111111	ATM	-0.922037395011648
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	1/300	77/9376	0.405887445887446	PLD1	-0.951688869798042
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	1/300	77/9376	0.405887445887446	SOS1	-0.951688869798042
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	1/300	83/9376	0.376546184738956	HSD17B4	-1.03720448618057
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	1/300	83/9376	0.376546184738956	IFI16	-1.03720448618057
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	5/300	268/9376	0.583084577114428	ITPR2/PRKN/NDUFB9/ATF6/NFE2L2	-1.25893372902657
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	2/300	138/9376	0.452946859903382	ATP6V1C1/NDUFB9	-1.17700715098063
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	1/300	86/9376	0.363410852713178	PRKCB	-1.07820072861975
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	1/300	89/9376	0.351161048689139	SPP1	-1.11813235889786
Human Diseases	Substance dependence	hsa05034	Alcoholism	3/300	191/9376	0.490890052356021	HDAC9/GNG2/SOS1	-1.29237249986785
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	10/300	480/9376	0.651111111111111	ITPR2/PRKN/DNAH11/PRKCB/NDUFB9/RAB1A/TANK/FIG4/ATF6/TNFRSF1A	-1.42662356081521
NA	NA	hsa04519	Cadherin signaling	8/300	404/9376	0.618877887788779	LIMD1/DAAM2/TJP1/MYO1D/PCDH7/ERBIN/IGF1R/TCF7L2	-1.42366962369974
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	1/300	103/9376	0.303430420711974	RNMT	-1.2923257812373
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	1/300	103/9376	0.303430420711974	SLC16A10	-1.2923257812373
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	1/300	103/9376	0.303430420711974	TNFRSF1A	-1.2923257812373
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	1/300	103/9376	0.303430420711974	PRKCB	-1.2923257812373
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	3/300	212/9376	0.442264150943396	IGF1/IGF1R/PRKCB	-1.49332031169659
NA	NA	hsa04382	Cornified envelope formation	3/300	217/9376	0.432073732718894	TJP1/UGCG/KAZN	-1.53885186483279
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	2/300	183/9376	0.341566484517304	PWP2/WDR36	-1.63533927065467
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	4/300	323/9376	0.38703818369453	PRKCB/NOTCH2/SOS1/ATM	-2.03815610660413
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	5/300	388/9376	0.402749140893471	ITPR2/APBB1/NDUFB9/ATF6/TNFRSF1A	-2.18444007825457
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	2/300	275/9376	0.22729696969697	ITPR2/NDUFB9	-2.36446792553176
Genetic Information Processing	Translation	hsa03010	Ribosome	1/300	222/9376	0.140780780780781	RPL10	-2.35545080407937
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	2/300	308/9376	0.202943722943723	DNAH11/NDUFB9	-2.58587549627287
Genetic Information Processing	Transcription	hsa03040	Spliceosome	1/300	243/9376	0.128614540466392	U2AF1	-2.50210619791996
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/300	449/9376	0.139213066072754	GRK3/PDE1A	-3.39832641447982