category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
NA	NA	hsa04517	IgSF CAM signaling	26/304	299/9376	2.68192219679634	NRP1/KCNQ3/SRGAP3/TJP1/JAML/MTSS1/CASK/UNC5C/ANK2/EPB41L1/CD28/CABLES1/EPB41L3/CNTNAP2/EPB41L2/CD209/PLXNA4/PRKCB/PMP22/NCK2/RASA1/INPP5D/BAIAP2/NRP2/CADM2/ROBO2	5.41054779471966
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	19/304	250/9376	2.344	WWP1/ASAP1/PLD1/EPS15/IL2RA/DNM1/RABEP1/CAPZB/SNX2/DAB2/PSD3/GRK3/FOLR2/IGF1R/CYTH4/RAB11A/WASHC3/ZFYVE16/ITCH	3.94275644262249
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	11/304	105/9376	3.23107769423559	EDA/BLNK/EDARADD/CXCL12/PRKCB/TAB2/SYK/TRAF3/ATM/TNFRSF1A/TNFSF13B	4.20839952088974
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	6/304	45/9376	4.11228070175439	ABCA1/ABCA6/ABCA8/ABCA9/CFTR/ABCD4	3.83082075066622
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	9/304	93/9376	2.98471986417657	RBPJ/IL2RA/IL12RB2/HLA-DMA/JAK2/HLA-DRB1/HLA-DMB/NOTCH2/NFATC2	3.52101134701428
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	17/304	250/9376	2.09726315789474	LGMN/OSBPL3/MCOLN1/GPR155/TPCN1/CTSC/OSBPL1A/ATP6V1C1/OSBPL6/AP3B1/NCOA7/DMXL1/DMXL2/MITF/ASAH1/FIG4/DTNBP1	3.21892960196561
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	8/304	78/9376	3.16329284750337	CR1/FCGR2A/HLA-DMA/JAK2/PRKCB/TAB2/HLA-DRB1/HLA-DMB	3.51187261117891
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	4/304	21/9376	5.87468671679198	BCAT1/VNN1/VNN2/PPCDC	4.09359968602173
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	6/304	50/9376	3.70105263157895	HLA-DMA/CD28/CXCL12/HLA-DRB1/HLA-DMB/TNFSF13B	3.50542962458534
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	14/304	200/9376	2.15894736842105	NAIP/TJP1/MYO1D/FCGR2A/MYO5A/NCK2/TAB2/RAB1A/CYTH4/MYO5B/BAIAP2/ARHGEF11/TNFRSF1A/TNFSF10	3.03265438031703
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	11/304	142/9376	2.38917716827279	ITPR2/FCGR2A/FCGR2B/BLNK/TAB2/SYK/LILRB4/CALCR/NFATC2/MITF/TNFRSF1A	3.05335839207717
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	7/304	70/9376	3.08421052631579	DTNA/HLA-DMA/CD28/DMD/SGCD/HLA-DRB1/HLA-DMB	3.20390765515872
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	9/304	109/9376	2.54659584741671	IL2RA/HIF1A/HLA-DMA/IL21R/JAK2/RORA/HLA-DRB1/HLA-DMB/NFATC2	2.97297609021186
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	8/304	91/9376	2.71139386928861	FCGR2B/BLNK/PRKCB/SYK/LILRB4/NFATC2/INPP5D/SOS1	3.00296743930638
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	11/304	155/9376	2.18879456706282	COLEC12/STX7/FCGR2A/FCGR2B/HLA-DMA/CD209/ATP6V1C1/HLA-DRB1/HLA-DMB/SCARB1/MRC1	2.73183559179146
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	8/304	98/9376	2.51772287862513	ASAP1/PLD1/FCGR2A/FCGR2B/PRKCB/PLA2G4C/SYK/INPP5D	2.7647078385813
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	7/304	80/9376	2.69868421052632	IGF1/FOXO3/JAK2/PRKCB/IGF1R/GAB1/SOS1	2.79306147888821
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	3/304	17/9376	5.44272445820434	PCDH7/CD209/NRP2	3.35606238343222
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	10/304	142/9376	2.17197924388436	WWP1/BIRC7/PRKN/MGRN1/COP1/PIAS2/MAP3K1/UBE2E1/ITCH/HERC1	2.57596564454322
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	6/304	66/9376	2.80382775119617	IL12RB2/HLA-DMA/IL21R/RORA/HLA-DRB1/HLA-DMB	2.69192589757415
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	4/304	34/9376	3.62848297213622	PER3/CRY1/RORA/PER2	2.81057775227753
Human Diseases	Substance dependence	hsa05032	Morphine addiction	7/304	91/9376	2.37246963562753	PDE4D/GNG2/KCNJ5/GRK3/PRKCB/PDE8A/PDE1A	2.40826013297534
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	3/304	21/9376	4.40601503759398	CSGALNACT1/CHSY1/CHST15	2.86025808396068
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	4/304	37/9376	3.33428165007112	HBB/HBA2/HBA1/PRKCB	2.60420302835521
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	7/304	93/9376	2.32144878324844	PLD1/ITPR2/MMP2/PRKCB/PLA2G4C/MAP3K1/SOS1	2.34432891225502
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	11/304	181/9376	1.87438208781623	CR1/FCGR2A/FCGR2B/HLA-DMA/CD209/JAK2/SYK/HLA-DRB1/HLA-DMB/MRC1/TNFRSF1A	2.1743806879214
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	7/304	95/9376	2.27257617728532	HLA-DMA/CD28/CXCL12/ATP6V1C1/HLA-DRB1/HLA-DMB/TNFSF13B	2.28201825635476
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	5/304	56/9376	2.75375939849624	MAN1A1/MGAT1/ST6GAL1/MAN1C1/MGAT4A	2.40950026281347
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	16/304	300/9376	1.64491228070175	IGF1/MEF2C/MKNK1/RPS6KA3/PRKCB/IGF1R/PLA2G4C/TAB2/RASA1/MAP2K5/MAP3K1/CACNA2D3/CACNB2/SOS1/TNFRSF1A/STK3	2.07818851326632
Human Diseases	Immune disease	hsa05330	Allograft rejection	4/304	39/9376	3.16329284750337	HLA-DMA/CD28/HLA-DRB1/HLA-DMB	2.4780772901939
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	3/304	24/9376	3.85526315789474	HS3ST2/HS6ST1/HS2ST1	2.56371900338937
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	7/304	99/9376	2.18075491759702	IGF1/HRH1/ITPR2/HTR2B/TRPV4/PRKCB/PLA2G4C	2.16194425302053
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	7/304	99/9376	2.18075491759702	IGF1/TTN/DTNA/DMD/SGCD/CACNA2D3/CACNB2	2.16194425302053
Organismal Systems	Nervous system	hsa04730	Long-term depression	5/304	60/9376	2.57017543859649	IGF1/ITPR2/PRKCB/IGF1R/PLA2G4C	2.23346923237316
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	8/304	122/9376	2.02243313201035	TBC1D4/HIF1A/THRB/NCOA1/MED13L/SLC16A10/PRKCB/NOTCH2	2.08075521302856
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	13/304	238/9376	1.68465280849182	PLD1/IGF1/GNG2/RGL1/PRKCB/IGF1R/PLA2G4C/RASA1/GAB1/RASAL2/RALGAPA2/RALGAPA1/SOS1	1.95841264630819
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	10/304	169/9376	1.82497664279041	ATG7/STX7/HIF1A/WDFY3/DAPK1/UVRAG/IGF1R/RAB1A/TANK/RB1CC1	1.981056412596
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	4/304	44/9376	2.80382775119617	MAN1A1/MGAT1/MAN1C1/MGAT4A	2.19535595355919
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	4/304	44/9376	2.80382775119617	HLA-DMA/CD28/HLA-DRB1/HLA-DMB	2.19535595355919
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	7/304	105/9376	2.05614035087719	IGF1/TTN/DTNA/DMD/SGCD/CACNA2D3/CACNB2	1.99215856897656
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/304	12/9376	5.14035087719298	FCGR2B/CD209	2.62704781239966
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	4/304	45/9376	2.74152046783626	HLA-DMA/CD28/HLA-DRB1/HLA-DMB	2.14358966469072
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	6/304	86/9376	2.15177478580171	DTNA/DMD/SGCD/TCF7L2/CACNA2D3/CACNB2	1.96417348808557
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	9/304	154/9376	1.80246069719754	MEF2C/ITPR2/KCNJ5/PRKCB/PLA2G4C/MAP2K5/NFATC2/CACNA2D3/CACNB2	1.83798719542748
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	6/304	89/9376	2.07924305144885	TJP1/ITPR2/HTR2B/PRKCB/MAP2K5/SOS1	1.87261048605019
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	4/304	48/9376	2.57017543859649	IL4I1/BCAT1/HADHB/ABAT	1.99639024387737
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	7/304	112/9376	1.92763157894737	BIRC7/HLA-DMA/JAK2/TAB2/HLA-DRB1/HLA-DMB/TNFRSF1A	1.80782410180364
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	4/304	50/9376	2.46736842105263	HBB/HBA2/CR1/HBA1	1.904352648742
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	7/304	115/9376	1.87734553775744	PDE4D/PLD1/MEF2C/ITPR2/AKAP13/PRKCB/ARHGEF11	1.73285234692249
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	4/304	51/9376	2.41898864809082	PLD1/ENPP2/CEPT1/PLA2G4C	1.85998952400656
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	7/304	116/9376	1.86116152450091	PLD1/GNG2/ITPR2/GRK3/GRIK1/PRKCB/PLA2G4C	1.7083585611825
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	10/304	187/9376	1.6493104418801	NAIP/PKN2/IFI16/ANTXR1/ITPR2/ERBIN/TAB2/TRAF3/TANK/P2RX7	1.64176114732216
Human Diseases	Immune disease	hsa05310	Asthma	3/304	32/9376	2.89144736842105	HLA-DMA/HLA-DRB1/HLA-DMB	1.96188589389356
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	4/304	52/9376	2.37246963562753	IGF1/IGF1R/PLA2G4C/SCARB1	1.81666225779818
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4/304	53/9376	2.32770605759682	DNM1/PRKCB/RAB11A/ATP2B1	1.77432404760989
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	11/304	216/9376	1.57066276803119	ABCA1/POU2F2/JAK2/TAB2/TRAF3/TANK/NFATC2/NFE2L2/TNFRSF1A/ATF6/TNFSF10	1.55320788496147
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	9/304	168/9376	1.65225563909774	IL2RA/IL12RB2/IL7/IL21R/JAK2/PTPN2/PIAS2/PRLR/SOS1	1.56156741219653
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	4/304	54/9376	2.28460038986355	HLA-DMA/CD28/HLA-DRB1/HLA-DMB	1.73293107398657
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	4/304	55/9376	2.24306220095694	ACER3/UGCG/SGMS1/ASAH1	1.69244225828694
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	10/304	196/9376	1.57357679914071	HIF1A/GNG2/ITPR2/CD200R1/JAK2/SYK/TCF7L2/TRAF3/NFATC2/TNFRSF1A	1.48548811115916
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	6/304	100/9376	1.85052631578947	CR1/IL2RA/HLA-DMA/IL7/HLA-DRB1/HLA-DMB	1.56523047398525
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	9/304	173/9376	1.60450258594463	HLA-DMA/JAK2/PRKCB/HLA-DRB1/HLA-DMB/TRAF3/RAB11A/TNFRSF1A/TNFSF10	1.46901899967524
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/304	36/9376	2.57017543859649	AKR1A1/CRYL1/UGP2	1.72781365184902
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	8/304	149/9376	1.65595196043801	LPAR6/PLD1/DNM1/PLA2G4C/SYK/CYTH4/GAB1/SOS1	1.47742627202582
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	10/304	201/9376	1.53443309766955	IGF1/MEF2C/PAX8/FLI1/NUPR1/MLLT3/IGF1R/PER2/MITF/ATM	1.40203626695465
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	3/304	38/9376	2.43490304709141	IGF1/PRKCB/NR3C2	1.62240146786427
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	6/304	105/9376	1.76240601503759	HIF1A/PRKN/FOXO3/BNIP3L/TBC1D17/MITF	1.43809833099827
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	9/304	180/9376	1.54210526315789	HLA-DMA/POU2F2/JAK2/TAB2/SYK/HLA-DRB1/HLA-DMB/TRAF3/TNFRSF1A	1.34428485013799
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/304	20/9376	3.08421052631579	NPL/UGP2	1.70797844481943
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	8/304	157/9376	1.57157224270868	ABCA1/HIF1A/P2RY6/VPS8/ATP8A1/JAK2/NFATC2/PPARD	1.32205632393487
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	9/304	184/9376	1.50858123569794	NRP1/SRGAP3/UNC5C/CXCL12/PLXNA4/NCK2/RASA1/NFATC2/ROBO2	1.27536691218909
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	6/304	110/9376	1.6822966507177	IGF1/HIF1A/MKNK1/PRKCB/IGF1R/PDK1	1.31763263627661
Human Diseases	Infectious disease: viral	hsa05162	Measles	7/304	136/9376	1.5874613003096	IL2RA/FCGR2B/CD28/RAB9A/CD209/TAB2/TRAF3	1.26323351665562
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/304	22/9376	2.80382775119617	HNMT/AOC1	1.55052449282133
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	4/304	65/9376	1.89797570850202	SPP1/ITPR2/KCNJ5/PRKCB	1.32982352895035
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	5/304	89/9376	1.73270254287404	GNG2/PRKCB/PLCL1/NSF/ABAT	1.27132295463901
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	5/304	90/9376	1.71345029239766	IGF1/FOXO3/IGF1R/APPL1/RB1CC1	1.24492028809999
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	6/304	115/9376	1.6091533180778	GNG2/ITPR2/KCNJ5/HTR2B/PRKCB/PLA2G4C	1.2031437004454
NA	NA	hsa04081	Hormone signaling	10/304	219/9376	1.40831530882	IGF1/GNG2/THRB/SLC16A10/JAK2/IGF1R/BMPR1A/CALCR/PRLR/APPL1	1.11921113588599
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	7/304	142/9376	1.52038547071905	MEF2C/MMP2/TRPV4/MAP2K5/BMPR1A/NFE2L2/TNFRSF1A	1.14378740194139
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	4/304	68/9376	1.81424148606811	PER2/TCF7L2/SOS1/PPARD	1.23353195482773
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	5/304	93/9376	1.65817770232032	TJP1/FER/IGF1R/TCF7L2/BAIAP2	1.16764647749575
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	4/304	69/9376	1.78794813119756	PLA2G4C/SYK/INPP5D/SOS1	1.20250870096384
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	8/304	170/9376	1.45139318885449	ARID1B/PRKCB/IGF1R/TCF7L2/GAB1/SMARCA2/NFE2L2/SOS1	1.08721362484565
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	4/304	70/9376	1.76240601503759	JAK2/APPL1/PPARA/TNFRSF1A	1.17199219420308
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	6/304	120/9376	1.54210526315789	FOXO3/RPS6KA3/MAP2K5/GAB1/MAP3K1/SOS1	1.094040710863
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	3/304	47/9376	1.96864501679731	AKR1A1/ME1/ACSS1	1.2186161803569
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	4/304	71/9376	1.73758339510749	FOXO3/JAK2/PRLR/SOS1	1.14196561128695
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	11/304	254/9376	1.33568172399503	MCOLN1/HRH1/ITPR2/TPCN1/HTR2B/PRKCB/P2RX7/ATP2B1/NFATC2/PHKB/PDE1A	0.992819801737716
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	6/304	122/9376	1.51682484900777	IGF1/ITPR2/JAK2/PRKCB/MAP3K1/SOS1	1.05179103173342
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/304	26/9376	2.37246963562753	SCARB1/ABCD4	1.28278691925713
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	5/304	97/9376	1.58979924036896	PER3/GNG2/KCNJ5/PRKCB/PER2	1.06883433827919
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	4/304	73/9376	1.68997837058399	FHIT/FOXO3/PRKCB/SOS1	1.08331886366422
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	3/304	49/9376	1.88829215896885	ST6GAL1/COLGALT2/GALNT17	1.14117904801134
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	5/304	98/9376	1.57357679914071	ITPR2/PRKCB/PIP4P2/INPP5D/IPMK	1.04483650799888
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	5/304	98/9376	1.57357679914071	ITPR2/KCNJ5/PRKCB/SCARB1/ATP2B1	1.04483650799888
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	9/304	204/9376	1.36068111455108	IGF1/HIF1A/ITPR2/ANK2/MMP2/PRKCB/IGF1R/GAB1/SOS1	0.953404885297394
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	5/304	99/9376	1.55768208399787	IGF1/MMP2/IGF1R/NOTCH2/SOS1	1.02110739370488
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	5/304	99/9376	1.55768208399787	FCGR2A/FCGR2B/HLA-DMA/HLA-DRB1/HLA-DMB	1.02110739370488
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	5/304	99/9376	1.55768208399787	PLD1/HIF1A/PRKCB/PLA2G4C/SOS1	1.02110739370488
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	3/304	51/9376	1.81424148606811	TJP1/ATP6V1C1/CFTR	1.06729580686631
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	4/304	76/9376	1.62326869806094	ME1/GK/PPARA/PPARD	0.998645955129797
Human Diseases	Cancer: specific types	hsa05214	Glioma	4/304	76/9376	1.62326869806094	IGF1/PRKCB/IGF1R/SOS1	0.998645955129797
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	5/304	102/9376	1.51186790505676	ITPR2/PRKCB/CFTR/RAB11A/ATP2B1	0.951470546188378
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/304	29/9376	2.12704174228675	LIMD1/STK3	1.11268898336722
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	7/304	158/9376	1.36642238507662	IGF1/ATP6V1C1/RPS6KA3/PRKCB/IGF1R/SOS1/TNFRSF1A	0.85028222057899
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	4/304	79/9376	1.5616255829447	DNM1/SYT1/ATP6V1C1/NSF	0.917613769314911
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	5/304	106/9376	1.45481628599801	IGF1/FOLR2/IGF1R/TCF7L2/SOS1	0.862025240271549
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	12/304	298/9376	1.24196397032851	TNFRSF25/IL2RA/EDA/IL12RB2/CXCL12/IL7/IL21R/BMPR1A/PRLR/TNFRSF1A/TNFSF13B/TNFSF10	0.777024395578434
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	6/304	133/9376	1.39137316976652	IGF1/FOXO3/IGF1R/ATM/SOS1/TNFSF10	0.832111076096413
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	3/304	56/9376	1.65225563909774	CR1/NAIP/RAB1A	0.896137825505116
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	4/304	82/9376	1.50449293966624	LGMN/HLA-DMA/HLA-DRB1/HLA-DMB	0.839907760541675
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	7/304	163/9376	1.32450758798838	JAK2/PRKCB/TAB2/TRAF3/MAP3K1/NFATC2/SOS1	0.765048613211841
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	2/304	32/9376	1.92763157894737	ACSS1/ABAT	0.962177081874756
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/304	32/9376	1.92763157894737	BIRC7/TNFRSF1A	0.962177081874756
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	5/304	109/9376	1.41477547078706	TBC1D4/RPS6KA3/PRKCB/PPARA/TNFRSF1A	0.797310790350293
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/304	10/9376	3.08421052631579	SELENBP1	1.20707823030833
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	6/304	137/9376	1.35074913561275	ITPR2/CTSC/NOL3/ATM/TNFRSF1A/TNFSF10	0.757033884352693
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	5/304	110/9376	1.40191387559809	IGF1/SPDYE16/SPDYE1/RPS6KA3/IGF1R	0.776165087287766
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	14/304	362/9376	1.1927886013376	SPP1/LPAR6/IGF1/IL2RA/PKN2/GNG2/FOXO3/IL7/JAK2/IGF1R/SYK/PRLR/SOS1/PHLPP2	0.684774800737477
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	6/304	138/9376	1.34096109839817	IGF1/ITPR2/SPDYE16/SPDYE1/RPS6KA3/IGF1R	0.738628915009569
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	6/304	138/9376	1.34096109839817	PKN2/FCGR2A/RPS6KA3/TAB2/NFATC2/BAIAP2	0.738628915009569
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	6/304	139/9376	1.33131389625142	ITPR2/KCNJ5/NCOA1/GREB1/MMP2/SOS1	0.720364810146885
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	3/304	59/9376	1.56824264049955	FOXO3/TCF7L2/SOS1	0.801479995449912
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	9/304	224/9376	1.23919172932331	NRP1/IL2RA/HLA-DMA/HLA-DRB1/HLA-DMB/MAP3K1/NFATC2/ATM/TNFRSF1A	0.663258877202787
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	4/304	86/9376	1.43451652386781	PRKCB/NCK2/GAB1/SOS1	0.741000625154491
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	3/304	60/9376	1.54210526315789	PRKCB/PLA2G4C/NFATC2	0.771108371847269
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	9/304	227/9376	1.22281474611639	GNG2/ITPR2/CXCL12/AKAP13/PRKCB/NFATC2/ARHGEF11/SOS1/TNFRSF1A	0.622072429340026
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	5/304	115/9376	1.34096109839817	KCNQ3/GNG2/ITPR2/JAK2/PRKCB	0.673435053968311
NA	NA	hsa04082	Neuroactive ligand signaling	8/304	199/9376	1.23988362866966	P2RY14/GNG2/HRH1/P2RY6/HTR2B/GRIK1/PRKCB/TAC3	0.626105748592633
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	6/304	144/9376	1.28508771929825	FOXO3/TAB2/TCF7L2/TRAF3/PPARA/TNFRSF1A	0.631077602586405
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	6/304	144/9376	1.28508771929825	RBPJ/ITPR2/PRKCB/RORA/PUM2/RB1CC1	0.631077602586405
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	3/304	62/9376	1.49235993208829	IGF1/FOXO3/IGF1R	0.712002207765283
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	3/304	62/9376	1.49235993208829	RBPJ/NOTCH2/ITCH	0.712002207765283
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/304	36/9376	1.71345029239766	GBE1/UGP2	0.785077339015195
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	4/304	90/9376	1.37076023391813	HIF1A/CD28/JAK2/NFATC2	0.646950379225733
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/304	37/9376	1.66714082503556	IL4I1/ABAT	0.744284716818155
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	2/304	37/9376	1.66714082503556	PAX8/TCF7L2	0.744284716818155
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	5/304	119/9376	1.29588677576294	RHBDF2/TAB2/TRAF3/TNFRSF1A/ITCH	0.594613566208966
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	9/304	233/9376	1.19132595437091	DAAM2/TTN/DTNA/CAPZB/ANK2/ACTG2/DMD/SGCD/DIAPH2	0.541350320470866
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	8/304	205/9376	1.20359435173299	RBPJ/HLA-DMA/BLNK/TAB2/SYK/HLA-DRB1/HLA-DMB/TRAF3	0.539517105141495
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	6/304	148/9376	1.25035561877667	IGF1/NCOA1/IGF1R/TCF7L2/NOTCH2/SOS1	0.56195988738326
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	2/304	38/9376	1.62326869806094	RENBP/UGP2	0.704711062296256
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	3/304	65/9376	1.42348178137652	ITPR2/SCARB1/PDE8A	0.627139500127172
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	9/304	238/9376	1.16629809818664	F13A1/NRP1/RPL10/FCGR2A/PRKCB/TAB2/SYK/TRAF3/TNFRSF1A	0.475686792643334
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	3/304	67/9376	1.38098978790259	AKR1A1/ACSS1/BPGM	0.57288853422222
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	3/304	67/9376	1.38098978790259	ITPR2/RPS6KA3/PRKCB	0.57288853422222
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	5/304	125/9376	1.23368421052632	PLD1/SGMS1/PRKCB/ASAH1/TNFRSF1A	0.481460812514767
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	2/304	41/9376	1.50449293966624	MMP2/DAPK1	0.592598801967911
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/304	42/9376	1.46867167919799	IL4I1/AOC1	0.55722471017624
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	3/304	70/9376	1.3218045112782	HIF1A/GAB1/SOS1	0.494687040551202
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	4/304	100/9376	1.23368421052632	IL2RA/CXCL12/TNFRSF1A/TNFSF10	0.430050947060303
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/304	43/9376	1.43451652386781	ABCA1/SCARB1	0.522758135878422
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/304	16/9376	1.92763157894737	IL4I1	0.679780184645468
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	3/304	72/9376	1.28508771929825	TRAF3/TANK/MAP3K1	0.444509263706248
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	6/304	160/9376	1.15657894736842	JAML/HLA-DMA/CD28/CNTNAP2/HLA-DRB1/HLA-DMB	0.365673119458203
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	2/304	44/9376	1.40191387559809	MNAT1/GTF2F2	0.489150928644488
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	2/304	44/9376	1.40191387559809	NSF/RAB11A	0.489150928644488
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	3/304	73/9376	1.267483777938	SERINC5/MLLT3/RANBP2	0.419970008797726
Human Diseases	Cancer: specific types	hsa05218	Melanoma	3/304	73/9376	1.267483777938	IGF1/IGF1R/MITF	0.419970008797726
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/304	17/9376	1.81424148606811	HSD17B4	0.615083210343326
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	5/304	133/9376	1.1594776414721	PRKCB/SYK/NFATC2/SOS1/TNFSF10	0.339070539602482
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	7/304	193/9376	1.11862557949277	GNG2/FOXO3/CXCL12/GRK3/JAK2/PRKCB/SOS1	0.304814497233619
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	4/304	104/9376	1.18623481781377	PLD1/SGMS1/CEPT1/PLA2G4C	0.349592209342198
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	5/304	134/9376	1.15082482325216	ITPR2/ACTG2/PRKCB/PLA2G4C/ARHGEF11	0.321894199912153
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	3/304	75/9376	1.23368421052632	IGF1/COP1/ATM	0.371934177363379
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	3/304	75/9376	1.23368421052632	PAX8/ITPR2/PRKCB	0.371934177363379
Cellular Processes	Cell motility	hsa04814	Motor proteins	7/304	194/9376	1.11285946825827	MYO1D/CAPZB/DNAH11/MYO5A/ACTG2/MYO5B/MYO9B	0.290764331385974
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	4/304	105/9376	1.1749373433584	ITPR2/CD209/SYK/NFATC2	0.329977855041681
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/304	18/9376	1.71345029239766	ABCD4	0.554599356888824
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	3/304	76/9376	1.21745152354571	ITPR2/PRKCB/CFTR	0.348416477678618
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	3/304	78/9376	1.18623481781377	INPP5D/IPMK/FIG4	0.302332139951771
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	2/304	50/9376	1.23368421052632	P4HA1/AOC1	0.303275672898654
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	5/304	143/9376	1.0783952889216	FCGR2A/HLA-DMA/CD28/HLA-DRB1/HLA-DMB	0.17292487690526
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	6/304	174/9376	1.06352087114338	MAN1A1/PRKN/MAN1C1/ERO1B/NFE2L2/ATF6	0.154817790259115
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	5/304	144/9376	1.07090643274854	IGF1/JAK2/IGF1R/BMPR1A/ZFHX3	0.156960326797132
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	2/304	52/9376	1.18623481781377	ABCA1/SCARB1	0.246508742946066
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	3/304	83/9376	1.1147748890298	AUTS2/SCML1/PHC3	0.192255542293156
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	6/304	178/9376	1.03962152572442	DAAM2/ROR1/PRKCB/TCF7L2/NFATC2/PPARD	0.0976934401205701
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	4/304	116/9376	1.06352087114338	CXCL12/MMP2/PRKCB/TXK	0.126011695766886
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	2/304	54/9376	1.14230019493177	IL4I1/BCAT1	0.191963533233717
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/304	23/9376	1.34096109839817	LARGE1	0.299684438000627
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/304	23/9376	1.34096109839817	NLN	0.299684438000627
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	5/304	149/9376	1.03496997527375	GNG2/ITPR2/KCNJ5/PRKCB/NDUFB9	0.0787642439044462
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	3/304	87/9376	1.06352087114338	TCF7L2/APPL1/SOS1	0.108958847175479
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	12/304	370/9376	1.00028449502134	LPAR6/P2RY14/THRB/HRH1/P2RY6/HTR2B/GRIK1/CALCR/P2RX7/PRLR/NR3C1/TAC3	0.00102206959901936
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	7/304	214/9376	1.00885391047713	GNG2/ITPR2/PRKCB/TAB2/NFATC2/ATM/TNFRSF1A	0.0239837881098735
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	2/304	56/9376	1.1015037593985	GRK3/MGRN1	0.13945660685094
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	3/304	88/9376	1.05143540669856	F13A1/CR1/A2M	0.0887387527085323
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	2/304	57/9376	1.08217913204063	HSD17B4/HADHB	0.113916132278051
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	4/304	122/9376	1.01121656600518	IGF1/FOXO3/CFTR/IGF1R	0.022826850438288
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	4/304	122/9376	1.01121656600518	CD28/NCK2/NFATC2/SOS1	0.022826850438288
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	5/304	154/9376	1.00136705399863	AKR1A1/DHRS3/BCAT1/UGP2/PPCDC	0.00313115365490186
NA	NA	hsa04518	Integrin signaling	5/304	154/9376	1.00136705399863	SPP1/IGF1/ITGAD/NCK2/IGF1R	0.00313115365490186
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	5/304	156/9376	0.988529014844804	SCARB1/TRAF3/PPARA/SOS1/TNFRSF1A	-0.0264465159013235
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/304	26/9376	1.18623481781377	PLA2G4C	0.174065481669109
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	5/304	157/9376	0.982232651692927	ITPR2/FOXO3/TRPV4/NFATC2/ATM	-0.0410961789844856
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	5/304	157/9376	0.982232651692927	LIMD1/TCF7L2/BMPR1A/DLG2/STK3	-0.0410961789844856
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	8/304	253/9376	0.975244435198669	NAIP/ITPR2/FOXO3/TAB2/CYTH4/ATM/U2AF1/TNFRSF1A	-0.0730693378226574
Organismal Systems	Digestive system	hsa04970	Salivary secretion	3/304	93/9376	0.99490662139219	ITPR2/PRKCB/ATP2B1	-0.00903595726350963
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	3/304	93/9376	0.99490662139219	FHIT/BIRC7/TRAF3	-0.00903595726350963
Organismal Systems	Immune system	hsa04611	Platelet activation	4/304	126/9376	0.979114452798663	ITPR2/FCGR2A/PLA2G4C/SYK	-0.0432047178878314
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/304	27/9376	1.14230019493177	ABAT	0.135542567022732
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/304	27/9376	1.14230019493177	HSD17B4	0.135542567022732
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	4/304	128/9376	0.963815789473684	PDE4D/FHIT/PDE8A/PDE1A	-0.0754520571574155
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/304	28/9376	1.1015037593985	HADHB	0.0984629176366887
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/304	28/9376	1.1015037593985	ATP6V1C1	0.0984629176366887
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	7/304	227/9376	0.951078135868305	PLD1/HIF1A/FOXO3/AKR1A1/NDUFB9/NFE2L2/SOS1	-0.136584060968518
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	6/304	195/9376	0.948987854251012	CR1/ATG7/HDAC9/FCGR2A/PRKCB/SYK	-0.131770081052161
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	2/304	63/9376	0.979114452798663	COLGALT2/KMT2C	-0.0304468411045597
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/304	29/9376	1.06352087114338	CNGA1	0.0627119394812441
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	2/304	65/9376	0.948987854251012	AKR1A1/GK	-0.0755445286960074
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/304	30/9376	1.0280701754386	PIGX	0.0281879683524506
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/304	30/9376	1.0280701754386	PLA2G4C	0.0281879683524506
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/304	30/9376	1.0280701754386	FOLR2	0.0281879683524506
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	5/304	166/9376	0.928979074191503	MEF2C/ITPR2/CNGA1/ATP2B1/NFATC2	-0.168997962055377
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	4/304	133/9376	0.927582113177681	GNG2/ITPR2/KCNJ5/PRKCB	-0.15396999689145
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/304	31/9376	0.99490662139219	AKR1A1	-0.0051995775891656
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/304	31/9376	0.99490662139219	ABAT	-0.0051995775891656
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/304	31/9376	0.99490662139219	ACSS1	-0.0051995775891656
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/304	31/9376	0.99490662139219	IMMP2L	-0.0051995775891656
NA	NA	hsa04981	Folate transport and metabolism	1/304	31/9376	0.99490662139219	FOLR2	-0.0051995775891656
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	3/304	101/9376	0.916102136529442	PRKCB/TCF7L2/MITF	-0.15517635212025
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	3/304	101/9376	0.916102136529442	MMP2/JAK2/PRKCB	-0.15517635212025
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	10/304	333/9376	0.926189347241979	RBPJ/SPP1/ATP6V1C1/TCF7L2/TRAF3/NOTCH2/DLG2/ATM/SOS1/TNFRSF1A	-0.251047445524534
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	6/304	203/9376	0.911589318122893	SPP1/IGF1/EMP2/PRKCB/IGF1R/SOS1	-0.233113793382739
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/304	32/9376	0.963815789473684	UGP2	-0.0375317301440507
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/304	32/9376	0.963815789473684	ATG7	-0.0375317301440507
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	6/304	205/9376	0.902695763799743	TBC1D4/PDK3/MMP2/PRKCB/NDUFB9/PPARA	-0.257852437387928
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	4/304	138/9376	0.89397406559878	MKNK1/PRKAR1A/SOS1/PHKB	-0.229685501535414
Organismal Systems	Endocrine system	hsa04924	Renin secretion	2/304	69/9376	0.89397406559878	ITPR2/PDE1A	-0.16180901203676
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/304	33/9376	0.934609250398724	BCAT1	-0.0688812501426684
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/304	33/9376	0.934609250398724	STX7	-0.0688812501426684
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	4/304	140/9376	0.881203007518797	SPP1/MEF2C/GNG2/ITPR2	-0.259237849986395
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	2/304	71/9376	0.868791697553744	TJP1/ATP6V1C1	-0.203143631354563
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	2/304	71/9376	0.868791697553744	HIF1A/PDK1	-0.203143631354563
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	3/304	107/9376	0.864731923266109	ITPR2/PPARA/PHKB	-0.257597516805117
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	3/304	109/9376	0.848865282472236	SPP1/TAB2/TRAF3	-0.290521859580491
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/304	36/9376	0.85672514619883	GALNT17	-0.157658973818625
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	7/304	248/9376	0.870543293718166	NAIP/RAB9A/TAB2/TCF7L2/CYTH4/TNFRSF1A/TNFSF10	-0.37821041767908
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/304	37/9376	0.833570412517781	IL4I1	-0.185674438950371
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/304	37/9376	0.833570412517781	UGP2	-0.185674438950371
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	6/304	217/9376	0.852777104050449	RPS6KA3/JAK2/PRKCB/NOTCH2/PPARA/SOS1	-0.40165400604587
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/304	38/9376	0.811634349030471	BLNK	-0.212979343271757
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	2/304	78/9376	0.790823211875843	DNM1/GAB1	-0.339575954293657
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/304	41/9376	0.752246469833119	BPGM	-0.291021803510959
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	1/304	41/9376	0.752246469833119	ATM	-0.291021803510959
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	4/304	155/9376	0.795925297113752	ITPR2/TCF7L2/SCARB1/PDE8A	-0.468961208416643
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	6/304	226/9376	0.818816953889148	PDE4D/PLD1/CFTR/CNGA1/ATP2B1/PPARA	-0.50469864489019
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	1/304	42/9376	0.734335839598997	ATG7	-0.315859996142682
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	4/304	157/9376	0.785786121354341	NDUFB9/PPARA/TNFRSF1A/ITCH	-0.495480346624269
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	2/304	83/9376	0.743183259353202	HSD17B4/ABCD4	-0.430185053197394
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/304	43/9376	0.717258261933905	HADHB	-0.340160927853283
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	4/304	158/9376	0.780812791472352	STAG1/NIPBL/ATM/TFDP2	-0.508623364673614
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	10/304	368/9376	0.838100686498856	PRKN/DNAH11/NDUFB9/RAB1A/TANK/RANBP2/FIG4/TNFRSF1A/ATF6/RB1CC1	-0.579996852872167
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	6/304	232/9376	0.797640653357532	IQGAP2/CXCL12/ITGAD/DIAPH2/BAIAP2/SOS1	-0.571307679028284
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/304	86/9376	0.717258261933905	SCN9A/PDE1A	-0.482172237776584
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	2/304	87/9376	0.709013914095584	CACNA2D3/CACNB2	-0.499135290394338
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/304	46/9376	0.670480549199085	BLVRB	-0.410100272932729
Organismal Systems	Digestive system	hsa04976	Bile secretion	2/304	90/9376	0.685380116959064	CFTR/SCARB1	-0.548989438522783
NA	NA	hsa03272	Virion - Hepatitis viruses	1/304	48/9376	0.642543859649123	SCARB1	-0.454485488480463
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/304	48/9376	0.642543859649123	PRKCB	-0.454485488480463
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	3/304	130/9376	0.711740890688259	GNG2/MMP2/SOS1	-0.605827078817943
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	4/304	168/9376	0.734335839598997	JAK2/PLA2G4C/TNFRSF1A/TNFSF10	-0.636027457032977
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	4/304	170/9376	0.725696594427245	TJP1/CFTR/MAP3K1/DLG2	-0.660679884508398
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	2/304	94/9376	0.656215005599104	TAB2/TRAF3	-0.613198340111708
Organismal Systems	Digestive system	hsa04978	Mineral absorption	1/304	61/9376	0.505608283002589	ATP2B1	-0.709113221827877
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	3/304	150/9376	0.616842105263158	TCF7L2/GAB1/SOS1	-0.86593958266436
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	2/304	108/9376	0.571150097465887	RANBP17/RANBP2	-0.820531182512031
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	1/304	63/9376	0.489557226399332	PLA2G4C	-0.744120796595441
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/304	63/9376	0.489557226399332	MNAT1	-0.744120796595441
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	1/304	63/9376	0.489557226399332	TCF7L2	-0.744120796595441
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	2/304	110/9376	0.560765550239234	BMPR1A/ZFYVE16	-0.848237559678773
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	3/304	154/9376	0.60082023239918	ATP2B1/CACNA2D3/CACNB2	-0.914296867231388
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	5/304	235/9376	0.656215005599104	ARID1B/RPS6KA3/NDUFB9/SMARCA2/SOS1	-0.977000762093391
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/304	68/9376	0.453560371517028	DHRS3	-0.827826578049789
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	2/304	116/9376	0.531760435571688	ME1/ACSS1	-0.928886214510191
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	2/304	117/9376	0.527215474583896	ARID1B/SMARCA2	-0.941987308172876
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	1/304	69/9376	0.44698703279939	PRKCB	-0.843967868537058
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	4/304	205/9376	0.601797175866496	RBPJ/HDAC9/SYK/TRAF3	-1.05522197991735
NA	NA	hsa04519	Cadherin signaling	9/304	404/9376	0.687076602397082	LIMD1/DAAM2/TJP1/MYO1D/PCDH7/ERBIN/IGF1R/TCF7L2/STK3	-1.17694182413257
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	11/304	480/9376	0.706798245614035	ITPR2/PRKN/DNAH11/PRKCB/NDUFB9/RAB1A/TANK/FIG4/TNFRSF1A/ATF6/RB1CC1	-1.20714851759889
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	1/304	75/9376	0.411228070175439	BCAT1	-0.937095419843469
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	1/304	75/9376	0.411228070175439	ATM	-0.937095419843469
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	1/304	77/9376	0.400546821599453	PLD1	-0.966837340790953
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	1/304	77/9376	0.400546821599453	SOS1	-0.966837340790953
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	1/304	83/9376	0.371591629676601	IFI16	-1.05262564868795
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	5/304	268/9376	0.57541241162608	ITPR2/PRKN/NDUFB9/NFE2L2/ATF6	-1.29090442623724
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	2/304	138/9376	0.44698703279939	ATP6V1C1/NDUFB9	-1.1979999180804
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	1/304	86/9376	0.358629130966952	PRKCB	-1.09375866924212
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	1/304	89/9376	0.346540508574808	SPP1	-1.13382717100573
Human Diseases	Substance dependence	hsa05034	Alcoholism	3/304	191/9376	0.484430972719757	HDAC9/GNG2/SOS1	-1.31775548270161
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	1/304	103/9376	0.29943791517629	RNMT	-1.30865756732099
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	1/304	103/9376	0.29943791517629	SLC16A10	-1.30865756732099
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	1/304	103/9376	0.29943791517629	TNFRSF1A	-1.30865756732099
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	1/304	103/9376	0.29943791517629	PRKCB	-1.30865756732099
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	3/304	212/9376	0.436444885799404	IGF1/PRKCB/IGF1R	-1.51926206789374
NA	NA	hsa04382	Cornified envelope formation	3/304	217/9376	0.426388552025224	TJP1/UGCG/KAZN	-1.56492870559882
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	2/304	183/9376	0.337072188668392	PWP2/WDR36	-1.65780735878344
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	6/304	388/9376	0.476939772110689	ITPR2/APBB1/NDUFB9/TNFRSF1A/ATF6/RB1CC1	-1.9262246614771
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	4/304	323/9376	0.381945576014339	PRKCB/NOTCH2/ATM/SOS1	-2.06920076180682
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	3/304	308/9376	0.30041011619959	DNAH11/NDUFB9/RB1CC1	-2.28525165758648
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	2/304	275/9376	0.224306220095694	ITPR2/NDUFB9	-2.38991804241424
Genetic Information Processing	Translation	hsa03010	Ribosome	1/304	222/9376	0.138928402086297	RPL10	-2.37673743627948
Genetic Information Processing	Transcription	hsa03040	Spliceosome	1/304	243/9376	0.126922243881308	U2AF1	-2.52417953192794
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/304	449/9376	0.137381315203376	GRK3/PDE1A	-3.42894226969527