category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	98/1042	238/9376	3.70509201761319	CFD/ISG15/RPLP1/C1R/RPL28/RPS18/RPL13A/RPL13/RPL32/RPS4X/RPS15/RPL34/RPS28/RPS15A/RPL36/RPS19/RPS6/RPL7/RPL21/RPS25/RPL27A/RPS27L/RPS3/RPS9/FGG/RPLP0/PRKCB/RPL19/RPS14/RPL30/RPL15/RPS12/RPL35A/RPS17/RPL31/RPL35/RPL41/RPL11/RPL23A/RPS24/RPL38/RPL8/RPS27/RPS23/IL6ST/RPLP2/RPL37A/MX1/RPL6/C3/PIK3CD/RPL37/RPS27A/FAU/RPS8/RPL14/RPS2/RPS7/FGB/FGA/RPL29/RPL10/OAS3/RPL23/RPS26/C1QC/UBA52/RPL10A/IKBKE/RPSA/RPL18/RPS13/RPL27/RPL3/RPS5/RPS20/RPL7A/PRKCG/RPS16/RPL36AL/PLCG1/RPL4/SYK/PLCG2/STAT1/PRKCA/OAS1/OAS2/VWF/RPS10-NUDT3/RPS29/C1QA/C5/TNF/IL6/NLRP3/HBEGF/STAT2	14.9464376278661
Genetic Information Processing	Translation	hsa03010	Ribosome	76/1042	222/9376	3.08042399405163	RPLP1/RPL28/RPS18/RPL13A/RPL13/RPL32/RPS4X/RPS15/RPL34/RPS28/RPS15A/RPL36/RPS19/RPS6/RPL7/RPL21/RPS25/RPL27A/RPS27L/RPS3/RPS9/RPLP0/RPL19/RPS14/RPL30/RPL15/RPS12/RPL35A/RPS17/RPL31/RPL35/RPL41/RPL11/RPL23A/RPS24/RPL38/RPL8/RPS27/RPS23/RPLP2/RPL37A/RPL6/RPL37/RPS27A/FAU/RPS8/RPL14/RPS2/RPS7/RPL29/RPL10/RPL23/RPS26/MRPL51/UBA52/RPL10A/RPSA/RPL18/RPS13/RPL27/RPL3/RACK1/RPS5/RPS20/RPL7A/RPS16/RPL36AL/MRPS23/MRPL24/RPL4/RPS10-NUDT3/RPS29/MRPS21/MRPL28/MRPL33/MRPL52	11.0921475178663
NA	NA	hsa04517	IgSF CAM signaling	80/1042	299/9376	2.40751320781363	MYL9/CD244/LCK/ACTB/MYL6/MBP/TUBA1A/NCAM1/MAG/TUBB6/JAML/CD2/FGG/JAM2/PRKCB/LCP2/ITGAX/PMP22/SLAMF6/ITGA4/ACTG1/LRFN4/ITGB1/KCNQ3/SLIT3/PIK3CD/SPTBN4/MSN/FGB/FGA/SLITRK4/TUBB1/ICAM3/TUBA3E/SPTBN1/ITGAM/ITGAL/PRKCQ/SLAMF1/FYN/SRGAP3/VAV1/PTPRS/SH2D1B/FGFR1/FOXO1/ACTN1/PRKCG/CLEC4M/SRGAP1/CD96/PLCG1/DOK1/MYL12A/TUBB/MPDZ/KCNA2/F11R/CLMP/CD48/PLCG2/PARD6G/NFASC/ARPC3/PRKCA/CDC42/DOK2/ICAM1/KDR/DYNLL1/UNC5D/SLIT2/TUBA1B/ARPC1B/VAV2/TIGIT/NECTIN2/ANK2/CNTNAP2/MAGI2	8.74600366366119
NA	NA	hsa04518	Integrin signaling	51/1042	154/9376	2.97988383976868	FN1/FLNA/ACTB/PARVG/TNC/COL6A3/FGG/COL1A2/CCND2/ITGAX/ITGA4/ACTG1/ITGB1/CCND3/ITGAD/C3/PIK3CD/ITGA1/COL6A2/COL9A2/FGB/FGA/PDGFA/PDGFRA/ICAM3/ITGAM/FBN1/COL4A1/ITGAL/RAC2/COL6A1/ACTN1/PDGFD/ITGB7/PDGFRB/LAMA1/COL4A2/CDC42/ICAM1/TGFB1/VWF/KDR/THBS1/ITGB8/ARHGEF6/IGF1/VEGFA/SPP1/COL1A1/THBS2/LAMC1	8.75951905996128
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	44/1042	133/9376	2.97680862424776	HLA-B/HLA-A/HLA-C/CD244/HLA-G/LCK/PTK2B/PRF1/TNFSF10/HLA-E/HCST/PRKCB/LCP2/CD247/TYROBP/FASLG/NCR3/PIK3CD/NCR1/ZAP70/KLRC2/IFNG/GZMB/ITGAL/NFATC2/KLRC1/FYN/VAV1/RAC2/SH2D1B/MICA/FCER1G/PRKCG/PLCG1/SYK/CD48/PLCG2/IFNGR2/PRKCA/ICAM1/KLRC4-KLRK1/VAV2/PPP3CA/TNF	8.11851730405344
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	49/1042	160/9376	2.75566218809981	HLA-B/HLA-A/HLA-DRB5/HLA-C/HLA-G/PTPRC/CD22/CD8B/VCAN/NCAM1/HLA-DQA1/HLA-E/MAG/JAML/CD2/JAM2/HLA-DRB1/ITGA4/HLA-DPA1/ITGB1/PDCD1/CLDN5/SLITRK4/ICAM3/ITGAM/CD99/ITGAL/HLA-DPB1/PTPRS/SDC2/HLA-F/PDCD1LG2/ITGB7/ICOS/SELL/HLA-DQB1/SIGLEC1/HLA-DOA/CD40LG/F11R/HLA-DRA/NFASC/CD276/ICAM1/NTNG2/ITGB8/TIGIT/NECTIN2/CNTNAP2	7.91995043534143
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	28/1042	70/9376	3.59923224568138	HLA-B/HLA-A/HLA-DRB5/HLA-C/HLA-G/ACTB/PRF1/HLA-DQA1/HLA-E/HLA-DRB1/ACTG1/HLA-DPA1/CAV1/ITGAL/FYN/HLA-DPB1/RAC2/HLA-F/SGCD/HLA-DQB1/SGCB/EIF4G3/LAMA1/HLA-DOA/CD40LG/HLA-DRA/SNTB1/ICAM1	7.71800990675318
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	54/1042	204/9376	2.38184486846562	LUM/DCN/FN1/MMP2/FLNA/ACTB/TIMP3/RPS6/TWIST2/COL1A2/PRKCB/ACTG1/ITGB1/FASLG/HOXD10/WNT10B/PIK3CD/CAV1/MSN/FZD2/WNT9B/PLAUR/ARHGEF1/CD63/CAMK2D/VAV1/TGFB2/FGFR1/SDC2/CD44/CBL/PRKCG/HCLS1/PLCG1/WNT6/WNT4/ESR1/CTSL/WNT9A/CAV2/PLCG2/PRKCA/HSPG2/CDC42/TGFB1/KDR/THBS1/VAV2/IGF1/VEGFA/ANK2/COL1A1/TNF/HBEGF	7.05561866445415
Human Diseases	Immune disease	hsa05330	Allograft rejection	20/1042	39/9376	4.61440031497613	HLA-B/HLA-A/HLA-DRB5/HLA-C/HLA-G/PRF1/HLA-DQA1/HLA-E/HLA-DRB1/HLA-DPA1/FASLG/IFNG/GZMB/HLA-DPB1/HLA-F/HLA-DQB1/HLA-DOA/CD40LG/HLA-DRA/TNF	7.99756217634539
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	37/1042	116/9376	2.87007743728903	MYL9/MMP2/ACTB/PTK2B/THY1/RHOH/CYBA/ITK/RASSF5/JAM2/PRKCB/ITGA4/ACTG1/ITGB1/CLDN5/PIK3CD/MSN/ARHGAP35/ITGAM/CD99/ITGAL/VAV1/RAC2/ACTN1/VASP/PRKCG/PLCG1/RAPGEF4/MYL12A/F11R/CXCR4/PLCG2/PRKCA/CDC42/ICAM1/VAV2/GNAI3	7.16598411843583
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	53/1042	203/9376	2.34925257415164	MYL9/FN1/FLNA/ACTB/PARVG/TNC/COL6A3/COL1A2/PRKCB/CCND2/ITGA4/ACTG1/ITGB1/CCND3/PIK3CD/CAV1/ITGA1/COL6A2/ARHGAP35/COL9A2/PDGFA/PDGFRA/COL4A1/FYN/VAV1/RAC2/CAPN2/COL6A1/ACTN1/VASP/PDGFD/ITGB7/PRKCG/PDGFRB/MYL12A/LAMA1/EMP1/COL4A2/CAV2/PRKCA/CDC42/VWF/KDR/THBS1/BIRC3/ITGB8/VAV2/IGF1/VEGFA/SPP1/COL1A1/THBS2/LAMC1	6.871923673275
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	58/1042	233/9376	2.23986556061717	MYL9/DCN/FN1/TPM2/SYNE1/ACTB/VCAN/PDLIM1/VIM/TPM1/COL6A3/ENO2/COL1A2/ITGA4/NID1/AGRN/ACTG1/ACTG2/ITGB1/FBLN2/ITGA1/COL6A2/SPTBN4/DES/TMOD3/COL9A2/SPTBN1/ENO1/FBN1/COL4A1/COL27A1/SDC2/COL6A1/SGCD/COL3A1/ITGB7/COL5A1/SGCB/LMOD1/LAMA1/LMNB1/COL4A2/ACTN2/SNTB1/HSPG2/THBS1/ITGB8/MYOM3/SUN2/ANK2/TNNI2/COL1A1/THBS2/ATP1B2/MYOT/COL5A3/COL5A2/FHL2	6.77642985473483
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	21/1042	45/9376	4.19910428662828	HLA-B/HLA-A/HLA-DRB5/HLA-C/HLA-G/PRF1/HLA-DQA1/HLA-E/HLA-DRB1/HLA-DPA1/FASLG/IFNG/GZMB/KLRC1/HLA-DPB1/HLA-F/HLA-DQB1/HLA-DOA/HLA-DRA/TNF/IL6	7.60612239325035
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	20/1042	44/9376	4.09003664281975	HLA-B/HLA-A/HLA-DRB5/HLA-C/HLA-G/PRF1/HLA-DQA1/HLA-E/HLA-DRB1/HLA-DPA1/FASLG/LTA/IFNG/GZMB/HLA-DPB1/HLA-F/HLA-DQB1/HLA-DOA/HLA-DRA/TNF	7.26432644445837
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	46/1042	180/9376	2.29950949029644	HLA-B/B2M/HLA-A/HLA-DRB5/HLA-C/HLA-G/HLA-DQA1/HLA-E/HLA-DRB1/CD74/HLA-DPA1/FASLG/C3/PIK3CD/TNFRSF14/LTA/NXF3/IFNG/OAS3/BST2/HLA-DPB1/IKBKE/TAP1/HLA-F/EIF4EBP1/ZC3HAV1/HLA-DQB1/CCL5/HLA-DOA/TNFSF14/SYK/HLA-DRA/IRF7/IFNGR2/STAT1/OAS1/OAS2/TRAF5/BIRC3/NECTIN2/C5/TNF/IL6/APAF1/SOCS3/STAT2	6.22456456930338
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	33/1042	109/9376	2.72418954374967	HLA-DRB5/LCK/IL2RB/HLA-DQA1/CD3D/HLA-DRB1/CD3E/CD247/HLA-DPA1/IL6ST/ZAP70/FOXP3/IFNG/TBX21/HSP90AB1/SMAD3/RUNX1/NFATC2/PRKCQ/HLA-DPB1/HLA-DQB1/PLCG1/HLA-DOA/HLA-DRA/IFNGR2/STAT1/TGFB1/JAK3/IL2RA/IL27RA/PPP3CA/TGFBR2/IL6	6.40208482531257
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	49/1042	205/9376	2.15076073217546	MMP2/CYBA/ATP5F1E/GYS1/GAPDH/PLN/COL1A2/PRKCB/MT-CO3/MT-CO1/MT-CO2/NDUFS5/PIK3CD/TBC1D4/NDUFA4/MT-ND3/COX7A1/SMAD3/CAMK2D/RAC2/MT-ND4/TGFB2/MT-ATP6/ATP2A3/COX7A2/MT-ND1/COL3A1/PRKCG/UQCR11/UQCRH/MT-ND2/NDUFB2/NDUFB10/NDUFA1/PDK3/UQCRQ/UQCRB/PRKCA/COX6C/TGFB1/NDUFB7/COX5B/NDUFA3/COX6B1/NDUFB11/NDUFB6/TGFBR2/COL1A1/ATP5MC2	5.8904214276531
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	30/1042	100/9376	2.69942418426104	HLA-DRB5/CD9/CD22/CD8B/HLA-DQA1/CD3D/CD2/CD7/CD38/HLA-DRB1/CD3E/ITGA4/CD37/HLA-DPA1/ITGA1/IL1R2/CD1D/GP1BA/ITGAM/IL7/HLA-DPB1/CD5/CD44/HLA-DQB1/HLA-DOA/HLA-DRA/KITLG/IL2RA/TNF/IL6	6.04107425509431
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	49/1042	212/9376	2.0797450476225	SKAP1/ACTB/CNR1/F2R/PFN1/RASSF5/PRKCB/APBB1IP/LCP2/ACTG1/ITGB1/RGS14/PIK3CD/FYB1/LPAR2/SIPA1L3/FGF6/PDGFA/PDGFRA/ITGAM/ITGAL/VAV1/RAC2/LPAR1/FGFR1/EVL/VASP/PDGFD/PRKCG/GRIN2B/EFNA1/EFNA5/PLCG1/PDGFRB/RAPGEF4/EFNA3/PARD6G/PRKCA/CDC42/KDR/THBS1/GNAO1/KITLG/VAV2/DOCK4/IGF1/VEGFA/MAGI2/GNAI3	5.62262812437231
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	28/1042	93/9376	2.70909953976018	HLA-DRB5/LCK/IL2RB/HLA-DQA1/CD3D/HLA-DRB1/CD3E/CD247/HLA-DPA1/ZAP70/IFNG/TBX21/DLL3/RUNX3/NFATC2/PRKCQ/HLA-DPB1/JAG2/HLA-DQB1/PLCG1/HLA-DOA/HLA-DRA/IFNGR2/STAT1/JAK3/IL2RA/MAF/PPP3CA	5.85675970532879
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	25/1042	82/9376	2.74331726042788	HLA-B/B2M/HLA-A/HLA-DRB5/HLA-C/HLA-G/CD8B/HLA-DQA1/HLA-E/HLA-DRB1/CD74/HLA-DPA1/KLRC2/IFNG/HSP90AB1/CTSB/KLRC1/HLA-DPB1/TAP1/HLA-F/HLA-DQB1/CTSL/HLA-DOA/HLA-DRA/TNF	5.60627983820046
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	38/1042	155/9376	2.20598105380472	HLA-B/HLA-A/HLA-DRB5/HLA-C/HLA-G/C1R/ACTB/CYBA/CORO1A/TUBA1A/HLA-DQA1/HLA-E/TUBB6/HLA-DRB1/ACTG1/HLA-DPA1/ITGB1/ATP6V0E1/MRC2/C3/TUBB1/TUBA3E/ITGAM/HLA-DPB1/SEC61G/COLEC11/TAP1/HLA-F/CLEC4M/HLA-DQB1/CTSL/TUBB/HLA-DOA/FCAR/HLA-DRA/THBS1/TUBA1B/THBS2	5.35315813316118
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	70/1042	362/9376	1.7399603397631	PRL/FN1/IL2RB/TNC/F2R/COL6A3/GYS1/RPS6/PIK3CG/COL1A2/CCND2/ITGA4/GNG2/ITGB1/CCND3/FASLG/PIK3R5/PIK3CD/ITGA1/COL6A2/LPAR2/CREB3L3/COL9A2/FGF6/EIF4E1B/PDGFA/PDGFRA/HSP90AB1/IL7/COL4A1/GNB1/LPAR1/FGFR1/COL6A1/DDIT4/EIF4EBP1/PDGFD/LPAR6/ITGB7/EFNA1/EFNA5/PDGFRB/YWHAH/LAMA1/COL4A2/EFNA3/PPP2R5D/SYK/BRCA1/PRKCA/VWF/KDR/SGK3/THBS1/HSP90B1/ITGB8/GNB5/GNG5/KITLG/JAK3/IGF1/IL2RA/VEGFA/SPP1/MAGI2/COL1A1/THBS2/IL6/YWHAQ/LAMC1	5.07687769538655
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	26/1042	89/9376	2.62865276369989	FN1/TNC/COL6A3/COL1A2/ITGA4/AGRN/ITGB1/ITGA1/COL6A2/COL9A2/GP1BA/COL4A1/CD44/COL6A1/ITGB7/LAMA1/COL4A2/HSPG2/VWF/THBS1/ITGB8/SV2C/SPP1/COL1A1/THBS2/LAMC1	5.4585655599559
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	56/1042	275/9376	1.83233641598325	CYBA/TUBA1A/NCAM1/ATP5F1E/TUBB6/MT-CO3/MT-CO1/MT-CO2/NDUFS5/PIK3CD/CAV1/NDUFA4/CREB3L3/MT-ND3/TUBB1/TUBA3E/COX7A1/C1QC/FYN/RAC2/MT-ND4/MT-ATP6/COX7A2/MT-ND1/GRIN2B/SOD1/UQCR11/UQCRH/CCL5/MT-ND2/NDUFB2/NDUFB10/NDUFA1/TUBB/PSMB4/UQCRQ/CAV2/UQCRB/RYR1/COX6C/NDUFB7/C1QA/TUBA1B/COX5B/NDUFA3/COX6B1/NDUFB11/NDUFB6/PPP3CA/C5/TNF/IL6/ATP5MC2/APAF1/LAMC1/PSMB5	4.95351446397035
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	45/1042	205/9376	1.97518842750808	HLA-B/B2M/HLA-A/HLA-DRB5/ISG15/HLA-C/HLA-G/VIM/HLA-DQA1/HLA-E/CD3D/HLA-DRB1/CD3E/CCND2/CD247/HLA-DPA1/CCND3/ENTPD3/PIK3CD/RUNX3/OAS3/ITGAL/HLA-DPB1/IKBKE/TAP1/HLA-F/CD44/RB1/HLA-DQB1/HLA-DOA/SYK/HLA-DRA/IRF7/PLCG2/STAT1/ICAM1/OAS1/OAS2/TRAF5/BTK/JAK3/TNF/IL6/APAF1/STAT2	4.99171604381531
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	18/1042	54/9376	2.99936020473448	HLA-B/HLA-A/HLA-DRB5/HLA-C/HLA-G/PRF1/HLA-DQA1/HLA-E/HLA-DRB1/HLA-DPA1/FASLG/GZMB/HLA-DPB1/HLA-F/HLA-DQB1/HLA-DOA/CD40LG/HLA-DRA	5.2098608499705
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	17/1042	50/9376	3.05934740882917	HBB/CD81/IFNG/HBA2/ITGAL/TGFB2/SDC2/ACKR1/CD40LG/GYPC/ICAM1/KLRC4-KLRK1/TGFB1/THBS1/TNF/THBS2/IL6	5.16249523557954
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	26/1042	100/9376	2.3395009596929	IL2RB/TNFSF10/CCL4L2/CCL21/XCR1/IL6ST/TNFRSF14/CCR2/LTA/CCL3L1/CCR4/CCR5/CCR7/CCL8/CXCR3/CCL5/CCL4/CXCL9/TNFSF14/IL10RA/CXCR4/CCL13/IL2RA/TNF/CCL23/IL6	4.76162740133862
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	22/1042	78/9376	2.53792017323687	HLA-DRB5/CYBA/HLA-DQA1/PRKCB/HLA-DRB1/EEF1A1/ITGA4/HLA-DPA1/ITGB1/C3/IFNG/ITGAM/HLA-DPB1/TGFB2/HLA-DQB1/HLA-DOA/NOS2/HLA-DRA/IFNGR2/STAT1/TGFB1/TNF	4.82257592495777
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	39/1042	184/9376	1.90720186931486	MYL9/SEMA5A/CFL1/ITGB1/SLIT3/PIK3CD/ABLIM2/TRPC3/BOC/NFATC2/CAMK2D/FYN/SRGAP3/RAC2/NTN4/SEMA4D/EFNA1/SRGAP1/ABLIM1/EFNA5/PLCG1/WNT4/MYL12A/EFNA3/CXCR4/PLCG2/PARD6G/PRKCA/CDC42/TRPC4/SSH2/NTNG2/UNC5D/SLIT2/RGS3/DPYSL2/PPP3CA/RND1/GNAI3	4.39441015591032
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	37/1042	173/9376	1.92444498685276	HLA-DRB5/ACTB/HLA-DQA1/TNFSF10/PRKCB/HLA-DRB1/ACTG1/HLA-DPA1/CCND3/MX1/FASLG/PIK3CD/NXF3/IFNG/OAS3/HLA-DPB1/IKBKE/HLA-DQB1/CCL5/HLA-DOA/TMPRSS4/HLA-DRA/IRF7/IFNGR2/STAT1/PRKCA/NLRX1/ICAM1/OAS1/OAS2/PYCARD/TNF/IL6/NLRP3/APAF1/SOCS3/STAT2	4.33942475176337
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	19/1042	66/9376	2.59035654045251	HLA-DRB5/HLA-DQA1/HLA-DRB1/HLA-DPA1/FOXP3/IFNG/TBX21/SMAD3/HLA-DPB1/TGFB2/HLA-DQB1/HLA-DOA/HLA-DRA/IFNGR2/STAT1/TGFB1/MAF/TNF/IL6	4.58441976428309
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	27/1042	112/9376	2.1691801480669	HLA-DRB5/HLA-DQA1/PIK3CG/HLA-DRB1/HLA-DPA1/ITGB1/PIK3R5/IFNG/CCR5/HLA-DPB1/TGFB2/HLA-DQB1/LAMA1/HLA-DOA/NOS2/CD40LG/LDLR/HLA-DRA/IL10RA/IFNGR2/STAT1/TGFB1/BIRC3/GNAO1/TNF/GNAI3/LAMC1	4.40132988286578
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	46/1042	235/9376	1.7613264180994	ACTB/CNR1/ATP5F1E/RPS6/ZNF516/MT-CO3/ACTG1/MT-CO1/MT-CO2/NDUFS5/NDUFA4/CREB3L3/MT-ND3/COX16/SMARCE1/NPR1/COX7A1/MT-ND4/FGFR1/MT-ATP6/COX7A2/MT-ND1/ADCY10/UQCR11/UQCRH/ATP5MG/MT-ND2/NDUFB2/NDUFB10/NDUFA1/DPF3/UQCRQ/UQCRB/COX6C/NDUFB7/NDUFAF3/COX5B/MGLL/NDUFA3/COX6B1/RPS6KA3/RPS6KA1/NDUFB11/NDUFB6/ATP5MC2/NDUFAF2	4.17927285745441
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	31/1042	138/9376	2.0213079640602	ATP5F1E/MT-CO3/MT-CO1/MT-CO2/NDUFS5/ATP6V0E1/NDUFA4/MT-ND3/COX7A1/MT-ND4/MT-ATP6/COX7A2/MT-ND1/UQCR11/UQCRH/ATP5MG/MT-ND2/NDUFB2/NDUFB10/NDUFA1/UQCRQ/UQCRB/PPA1/COX6C/NDUFB7/COX5B/NDUFA3/COX6B1/NDUFB11/NDUFB6/ATP5MC2	4.27366063353877
Human Diseases	Immune disease	hsa05310	Asthma	12/1042	32/9376	3.3742802303263	PRG2/HLA-DRB5/HLA-DQA1/HLA-DRB1/HLA-DPA1/HLA-DPB1/FCER1G/HLA-DQB1/HLA-DOA/CD40LG/HLA-DRA/TNF	4.75700162993685
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	40/1042	196/9376	1.8363429824905	HLA-B/HLA-A/HLA-C/HLA-G/HLA-E/PIK3CG/GNG2/TCF7L2/IL6ST/PIK3R5/C3/PIK3CD/RPS27A/LEF1/CCR4/CCR5/NFATC2/GNB1/UBA52/CLEC2B/MICA/IKBKE/HLA-F/RB1/PLCG1/SYK/IRF7/PLCG2/UBB/STAT1/TCF7L1/TCF7/UBC/ICAM1/GNB5/GNG5/VEGFA/PPP3CA/IL6/STAT2	4.18392472103426
Organismal Systems	Immune system	hsa04611	Platelet activation	29/1042	126/9376	2.07098680803095	ACTB/F2R/FGG/PIK3CG/COL1A2/APBB1IP/LCP2/ACTG1/P2RX1/ITGB1/PIK3R5/PIK3CD/ARHGAP35/FGB/FGA/GP1BA/ARHGEF1/FYN/VASP/COL3A1/FCER1G/MYL12A/SYK/PLCG2/VWF/BTK/TBXA2R/COL1A1/GNAI3	4.27948272123727
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	44/1042	224/9376	1.76748012064711	HLA-B/B2M/HLA-A/HLA-DRB5/HLA-C/TSPO/HLA-G/LCK/IL2RB/HLA-DQA1/HLA-E/CD3D/HLA-DRB1/CD3E/CCND2/ETS1/HLA-DPA1/CCND3/PIK3CD/IL1R2/CREB3L3/LTA/PTTG1/SMAD3/ITGAL/NFATC2/HLA-DPB1/TGFB2/HLA-F/ETS2/RB1/HLA-DQB1/HLA-DOA/HLA-DRA/ICAM1/TGFB1/MAP3K3/JAK3/IL2RA/PPP3CA/TGFBR2/TNF/IL6/CHEK2	4.11079564929801
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	25/1042	103/9376	2.18400014907851	FN1/COL1A2/PRKCB/PIK3CD/IL1R2/CD1D/IFNG/ARG1/ITGAM/COL4A1/SERPINB6/TGFB2/ACTN1/COL3A1/PRKCG/LAMA1/COL4A2/NOS2/GNA14/PRKCA/TGFB1/COL1A1/TNF/IL6/LAMC1	4.27221390445607
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	50/1042	268/9376	1.67874638324691	TUBA1A/ATP5F1E/TUBB6/MAOB/MT-CO3/MT-CO1/MT-CO2/NDUFS5/UCHL1/RPS27A/TXN/NDUFA4/MT-ND3/TUBB1/TUBA3E/COX7A1/CAMK2D/UBA52/MT-ND4/UBE2L6/MT-ATP6/COX7A2/MT-ND1/SOD1/UQCR11/UQCRH/PLCG1/MT-ND2/NDUFB2/NDUFB10/NDUFA1/TUBB/PSMB4/UQCRQ/UBB/UQCRB/COX6C/UBC/NDUFB7/TUBA1B/COX5B/NDUFA3/COX6B1/NDUFB11/NDUFB6/SLC18A2/ATP5MC2/GNAI3/APAF1/PSMB5	3.98617319211393
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	59/1042	333/9376	1.59425452323725	HLA-B/HLA-A/ISG15/FN1/HLA-C/HLA-G/TNC/HLA-E/COL6A3/COL1A2/CCND2/ITGA4/TCF7L2/ITGB1/CCND3/ATP6V0E1/MX1/FASLG/WNT10B/PIK3CD/ITGA1/COL6A2/CREB3L3/COL9A2/FZD2/WNT9B/COL4A1/IKBKE/HLA-F/COL6A1/FOXO1/EIF4EBP1/ITGB7/OASL/RB1/LLGL2/PDGFRB/WNT6/WNT4/LAMA1/COL4A2/PPP2R5D/WNT9A/PARD6G/STAT1/TCF7L1/TCF7/CDC42/VWF/PATJ/THBS1/ITGB8/VEGFA/SPP1/COL1A1/TNF/THBS2/LAMC1/STAT2	3.90419136923292
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	24/1042	101/9376	2.13815776971171	FN1/MMP2/COL1A2/PRKCB/PIK3CD/COL4A1/SMAD3/TGFB2/FOXO1/COL3A1/F3/PLCG1/COL4A2/PLCG2/STAT1/PRKCA/CDC42/ICAM1/TGFB1/VEGFA/TGFBR2/COL1A1/TNF/IL6	4.06629558399547
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	15/1042	50/9376	2.69942418426104	HLA-DRB5/HLA-DQA1/HLA-DRB1/ITGA4/HLA-DPA1/HLA-DPB1/ITGB7/ICOS/HLA-DQB1/HLA-DOA/CD40LG/HLA-DRA/CXCR4/TGFB1/IL6	4.26021817244727
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	46/1042	248/9376	1.66899882360225	MYL9/FLNA/ACTB/PTPRC/RHOH/TUBA1A/TNFSF10/PFN1/GAPDH/TUBB6/RPS3/PIK3CG/S100A10/ACTG1/TCF7L2/PIK3CD/TXN/LEF1/TUBB1/HSP90AB1/TUBA3E/NAIP/CYTH4/FYCO1/RHOJ/SKP1/ANXA2/MYL12A/TUBB/TCF7L1/TCF7/ARPC3/CDC42/AHNAK2/PYCARD/DYNLL1/HSP90B1/TUBA1B/BIRC3/ARPC1B/RHOG/BRK1/AHNAK/TNF/IL6/NLRP3	3.77534051242065
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	24/1042	103/9376	2.09664014311537	COL18A1/COL6A3/FXYD2/COL1A2/COL6A2/CELA3B/COL9A2/PRCP/COL4A1/KCNQ1/COL27A1/COL6A1/COL3A1/COL5A1/CPB1/COL4A2/SLC1A1/COL16A1/SLC7A7/COL1A1/ATP1B2/CPB2/COL5A3/COL5A2	3.95699381562452
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	25/1042	110/9376	2.04501832140988	TIMP1/RPS6/GAPDH/ENO2/PRKCB/PIK3CD/IFNG/EIF4E1B/ENO1/LDHA/ELOB/CAMK2D/EIF4EBP1/PRKCG/PLCG1/NOS2/PLCG2/PDK1/IFNGR2/PRKCA/PFKP/PGK1/IGF1/VEGFA/IL6	3.89822452003967
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	21/1042	86/9376	2.19720573137526	ACTB/ITGA4/ACTG1/TCF7L2/ITGB1/ITGA1/CACNB2/LEF1/DES/GJA1/ATP2A3/SGCD/ITGB7/SGCB/LAMA1/ACTN2/CACNG5/SNTB1/TCF7L1/TCF7/ITGB8	3.94369123778032
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	23/1042	99/9376	2.09046317299676	CFD/HLA-DRB5/C1R/HLA-DQA1/FGG/HLA-DRB1/CFH/HLA-DPA1/C3/KRT26/DEFB1/ITGAM/ITGAL/C1QC/HLA-DPB1/HLA-DQB1/HLA-DOA/FCAR/HLA-DRA/ICAM1/FPR3/C1QA/C5	3.85671522096678
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	12/1042	37/9376	2.91829641541734	HBB/PRKCB/FASLG/IFNG/HBA2/IDO1/PRKCG/PRKCA/ICAM1/APOA1/TNF/IL6	4.13389212313226
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	29/1042	138/9376	1.89090099863696	FN1/LCK/ACTB/PTK2B/CD8B/LCP2/ITGA4/ACTG1/ITGB1/PIK3CD/ZAP70/WIPF1/FYB1/ARHGEF1/NFATC2/VAV1/RAC2/PLCG1/ARPC3/CDC42/PYCARD/ARPC1B/VAV2/RPS6KA3/RPS6KA1/RHOG/TNF/IL6/NLRP3	3.72797301131271
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	21/1042	88/9376	2.14726923748037	CFD/SERPINE2/SERPING1/C1R/F2R/FGG/CFH/ITGAX/C3/FGB/FGA/PLAUR/ITGAM/C1QC/F3/A2M/CLU/VWF/C1QA/C5/CPB2	3.82329959698551
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	22/1042	95/9376	2.08376603697343	HLA-DRB5/HLA-DQA1/HLA-DRB1/HLA-DPA1/ATP6V0E1/IFNG/CCL3L1/ITGAL/LTB/HLA-DPB1/TGFB2/HLA-DQB1/CCL5/CTSL/HLA-DOA/HLA-DRA/ICAM1/TGFB1/VEGFA/TNF/IL6/CTSK	3.75398646908737
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	37/1042	193/9376	1.72502063588356	PTK2B/ITK/CCL4L2/PIK3CG/PRKCB/GNG2/CCL21/XCR1/CXCR6/PIK3R5/PIK3CD/CCR2/CCL3L1/CCR4/CCR5/CCR7/GNB1/VAV1/RAC2/CCL8/CXCR3/CCL5/CCL4/PLCG1/CXCL9/CXCR4/CCL13/PLCG2/STAT1/CDC42/GNB5/GNG5/VAV2/JAK3/CCL23/GNAI3/STAT2	3.59856606194086
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	38/1042	200/9376	1.70963531669866	ACTB/TUBA1A/TNFSF10/MYO1F/F2R/GAPDH/TUBB6/RPS3/ACTG1/MYO5A/ITGB1/FASLG/CLDN5/WIPF1/LPAR2/MYO10/TUBB1/TUBA3E/ARHGEF1/ARHGEF2/FYN/NAIP/CYTH4/LPAR1/HCLS1/TUBB/NLRP4/ARPC3/CDC42/BAIAP2L1/MYO1G/PYCARD/TUBA1B/ARPC1B/BRK1/TNF/IL6/NLRP3	3.58687519805612
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	76/1042	480/9376	1.42469609724888	DKK1/HIP1/TUBA1A/ATP5F1E/TUBB6/PRKCB/ATXN1/MT-CO3/WDR41/MT-CO1/MT-CO2/NDUFS5/UCHL1/FASLG/WNT10B/RPS27A/NDUFA4/MT-ND3/TRPC3/FZD2/WNT9B/NEFH/TUBB1/TUBA3E/COX7A1/CAMK2D/UBA52/MT-ND4/UBE2L6/GPX8/CAPN2/MT-ATP6/ATP2A3/COX7A2/CCS/MT-ND1/PRKCG/GRIN2B/SOD1/UQCR11/UQCRH/PLCG1/MT-ND2/WNT6/WNT4/NDUFB2/NDUFB10/NDUFA1/TUBB/PSMB4/NOS2/UQCRQ/WNT9A/UBB/UQCRB/ULK2/RYR1/PRKCA/COX6C/UBC/GRIA4/NDUFB7/TUBA1B/COX5B/NDUFA3/COX6B1/GPX7/NDUFB11/NDUFB6/PPP3CA/TNF/IL6/CHRFAM7A/ATP5MC2/APAF1/PSMB5	3.37749139516343
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	29/1042	142/9376	1.83763618177395	MMP2/ACTB/CYBA/ACTG1/GSTA1/PIK3CD/CAV1/MEF2A/TXN/IL1R2/GSTO1/GSTM5/IFNG/PDGFA/HSP90AB1/ARHGEF2/RAC2/MGST1/SDC2/GSTO2/CTSL/CAV2/ICAM1/GSTM4/KDR/HSP90B1/VEGFA/SUMO1/TNF	3.55629201933686
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	42/1042	232/9376	1.62896286981269	TMSB4X/MYL9/FN1/ACTB/F2R/PFN1/ITGAX/ITGA4/ACTG1/CFL1/ITGB1/ITGAD/PIK3CD/ITGA1/MSN/LPAR2/ARHGAP35/FGF6/PDGFA/PDGFRA/ARHGEF1/ITGAM/ITGAL/VAV1/RAC2/LPAR1/FGFR1/ACTN1/PDGFD/ITGB7/PDGFRB/MYL12A/CXCR4/ARPC3/CDC42/SSH2/ITGB8/ARPC1B/VAV2/ARHGEF6/BRK1/C5	3.42999622005366
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	19/1042	80/9376	2.13704414587332	RPS6/PRKCB/PIK3CD/EIF4E1B/PDGFA/PDGFRA/EIF4EBP1/PDGFD/PRKCG/AXL/PLCG1/PDGFRB/NRG1/PLCG2/PRKCA/KDR/IGF1/VEGFA/IL6	3.61132864022286
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	31/1042	157/9376	1.77669107668985	PKLR/MT-CO3/MT-CO1/MT-CO2/NDUFS5/FASLG/PIK3CD/NDUFA4/COX7A1/COX7A2/UQCR11/UQCRH/MLXIP/NDUFB2/NDUFB10/NDUFA1/UQCRQ/UQCRB/CDC42/COX6C/TGFB1/NDUFB7/COX5B/NDUFA3/COX6B1/NDUFB11/NDUFB6/TNF/IL6/SOCS3/IRS2	3.4701558812133
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	51/1042	298/9376	1.53993997088717	PRL/IL2RB/TNFRSF18/TNFRSF11B/CD27/TNFSF10/CCL4L2/CCL21/XCR1/IL6ST/CXCR6/IL32/FASLG/CD70/TNFRSF14/IL1R2/IL17RA/TNFRSF9/CCR2/LTA/IFNG/CCL3L1/CCR4/CCR5/CCR7/IL7/LTB/CCL8/TGFB2/CXCR3/CCL5/IL17RE/CCL4/TNFRSF19/IL16/CXCL9/TNFSF14/LIF/CD40LG/IL10RA/CXCR4/CCL13/IFNGR2/TGFB1/ACVR1B/IL2RA/IL27RA/TGFBR2/TNF/CCL23/IL6	3.34927857434015
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	22/1042	99/9376	1.99957346982299	TPM2/ACTB/TPM1/ITGA4/ACTG1/ITGB1/ITGA1/CACNB2/DES/TGFB2/ATP2A3/SGCD/ITGB7/SGCB/LAMA1/CACNG5/SNTB1/TGFB1/ITGB8/IGF1/TNF/IL6	3.53525943012506
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	41/1042	227/9376	1.62520398758741	HLA-B/B2M/HLA-A/HLA-C/HLA-G/PTK2B/HLA-E/CCL4L2/PRKCB/PTGER3/GNG2/FASLG/PIK3CD/CREB3L3/CCL3L1/PDGFRA/CCR5/ARHGEF1/NFATC2/GNB1/RAC2/PTGER2/TAP1/HLA-F/EIF4EBP1/PRKCG/RB1/CCL5/CCL4/IL10RA/CXCR4/PRKCA/TRAF5/GNB5/GNG5/GNAO1/VEGFA/PPP3CA/TNF/IL6/GNAI3	3.37163539014539
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	20/1042	87/9376	2.06852427912723	TPM2/TPM1/FXYD2/MT-CO3/MT-CO1/MT-CO2/CACNB2/COX7A1/ATP2A3/COX7A2/UQCR11/UQCRH/ASPH/CACNG5/UQCRQ/UQCRB/COX6C/COX5B/COX6B1/ATP1B2	3.54039965039218
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	25/1042	122/9376	1.84386897832038	LCK/PTPRC/CD8B/ITK/CD3D/CD3E/LCP2/CD247/CARD11/PDCD1/PIK3CD/ZAP70/IFNG/NFATC2/PRKCQ/FYN/VAV1/ICOS/PLCG1/PPP2R5D/CD40LG/CDC42/VAV2/PPP3CA/TNF	3.31728617941826
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	32/1042	170/9376	1.69375635090889	ACTB/PRKCB/ACTG1/TCF7L2/TXNRD1/GSTA1/WNT10B/PIK3CD/LEF1/GSTO1/GSTM5/SMARCE1/FZD2/WNT9B/SMAD3/MGST1/TGFB2/PRKCG/RB1/PLCG1/WNT6/WNT4/GSTO2/DPF3/WNT9A/PLCG2/TCF7L1/TCF7/PRKCA/GSTM4/TGFB1/TGFBR2	3.22766681339601
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	40/1042	227/9376	1.58556486593893	CYBA/ATP5F1E/MT-CO3/MT-CO1/MT-CO2/NDUFS5/GSTA1/PIK3CD/NDUFA4/GSTO1/MT-ND3/GSTM5/COX7A1/MT-ND4/MGST1/PLD1/MT-ATP6/COX7A2/MT-ND1/SOD1/UQCR11/UQCRH/MT-ND2/GSTO2/AKR1A1/NDUFB2/NDUFB10/NDUFA1/UQCRQ/UQCRB/COX6C/GSTM4/NDUFB7/COX5B/NDUFA3/COX6B1/VEGFA/NDUFB11/NDUFB6/ATP5MC2	3.15786729519129
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	11/1042	38/9376	2.60470754621679	LCK/PTPRC/CD8B/CD3D/CD3E/ZAP70/TAP1/ICOS/CD40LG/BTK/JAK3	3.50472146163724
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	21/1042	98/9376	1.92816013161503	PTPRC/PRKCB/CFL1/PIK3CD/MYO10/VAV1/RAC2/ASAP3/PLD1/PLPP1/VASP/PRKCG/PLCG1/SYK/PLCG2/ARPC3/PRKCA/CDC42/BIN1/ARPC1B/VAV2	3.26588970007292
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	38/1042	214/9376	1.59779001560622	HLA-B/B2M/HLA-A/HLA-C/HLA-G/PTK2B/HLA-E/CD3D/PRKCB/CD3E/CD247/GNG2/CFL1/FASLG/PIK3CD/CCR5/BST2/NFATC2/ELOB/GNB1/RAC2/TAP1/HLA-F/APOBEC3G/PRKCG/SKP1/PLCG1/CXCR4/PLCG2/PRKCA/TRAF5/GNB5/GNG5/GNAO1/AP1S1/PPP3CA/TNF/GNAI3	3.12790208581394
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	22/1042	105/9376	1.88531212869025	LCK/CCL4L2/PRKCB/CCL21/CARD11/ZAP70/TRAF1/LTA/PRKCQ/LTB/CCL4/PLCG1/TNFSF14/CD40LG/SYK/CCL13/PLCG2/ICAM1/TRAF5/BIRC3/BTK/TNF	3.22567436395843
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	22/1042	105/9376	1.88531212869025	TPM2/ACTB/TPM1/PLN/ITGA4/ACTG1/ITGB1/ITGA1/CACNB2/DES/TGFB2/ATP2A3/SGCD/ITGB7/SGCB/LAMA1/CACNG5/SNTB1/TGFB1/ITGB8/IGF1/TNF	3.22567436395843
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	27/1042	142/9376	1.71090265199643	LCK/CYBA/TNFRSF11B/LCP2/TYROBP/PIK3CD/FOSL2/IFNG/LILRA1/NFATC2/FYN/TGFB2/ATP2A3/CAMK4/SYK/PLCG2/IFNGR2/STAT1/TGFB1/BTK/PPP3CA/TGFBR2/TNF/CTSK/SOCS3/FHL2/STAT2	3.01822853743751
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	21/1042	103/9376	1.83456012522595	CD3D/CD3E/CD247/FASLG/C3/PIK3CD/IFNG/CCL3L1/C1QC/TGFB2/CCL5/NOS2/GNA14/IFNGR2/TGFB1/C1QA/GNAO1/TGFBR2/TNF/IL6/GNAI3	3.01133354912988
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	32/1042	181/9376	1.59082088206912	HLA-DRB5/CORO1A/HLA-DQA1/HLA-DRB1/ITGAX/CD74/HLA-DPA1/MRC2/C3/IFNG/ITGAM/CAMK2D/HLA-DPB1/CASP10/LSP1/TGFB2/FCER1G/CLEC4M/HLA-DQB1/IRAK2/HLA-DOA/NOS2/SYK/HLA-DRA/IL10RA/IFNGR2/STAT1/TGFB1/PPP3CA/TNF/IL6/APAF1	2.83799748957038
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	12/1042	50/9376	2.15953934740883	PYCR1/OAT/AOC1/SMOX/MAOB/ARG1/P4HA2/SAT2/ALDH3A2/NOS2/P4HA3/GAMT	2.90680257774886
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	25/1042	137/9376	1.64198551354078	ACTB/PRF1/CTSC/TUBA1A/CTSW/TNFSF10/ACTG1/FASLG/PTPN13/PIK3CD/TRAF1/GZMB/TUBA3E/CTSB/CASP10/CAPN2/PARP4/CTSL/LMNB1/TUBA1B/BIRC3/CTSZ/TNF/APAF1/CTSK	2.67649094190202
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	58/1042	388/9376	1.34507390624691	DKK1/TUBA1A/ATP5F1E/GAPDH/TUBB6/APBB1/MT-CO3/MT-CO1/MT-CO2/NDUFS5/WNT10B/PIK3CD/NDUFA4/MT-ND3/FZD2/WNT9B/TUBB1/TUBA3E/COX7A1/MT-ND4/CAPN2/MT-ATP6/ATP2A3/COX7A2/MT-ND1/GRIN2B/UQCR11/UQCRH/MT-ND2/WNT6/WNT4/NDUFB2/NDUFB10/NDUFA1/TUBB/PSMB4/NOS2/UQCRQ/WNT9A/UQCRB/APOE/ULK2/COX6C/NDUFB7/TUBA1B/COX5B/NDUFA3/COX6B1/NDUFB11/NDUFB6/PPP3CA/TNF/IL6/CHRFAM7A/ATP5MC2/APAF1/PSMB5/IRS2	2.45464787664273
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	30/1042	178/9376	1.51653044059609	DKK1/NOTUM/PRKCB/CCND2/TLE6/TCF7L2/CCND3/WNT10B/CTNND2/LEF1/BAMBI/VANGL1/CCDC88C/FZD2/WNT9B/SMAD3/NFATC2/CAMK2D/RAC2/PRKCG/SKP1/WNT6/WNT4/RSPO2/CELSR1/WNT9A/TCF7L1/TCF7/PRKCA/PPP3CA	2.46009551349916
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	26/1042	149/9376	1.57013487227711	CNR1/PRKCB/GNG2/NDUFS5/NDUFA4/MT-ND3/GNB1/MT-ND4/MT-ND1/PRKCG/MT-ND2/GABRA2/NDUFB2/NDUFB10/NDUFA1/PRKCA/GRIA4/NDUFB7/GNB5/GNG5/GNAO1/MGLL/NDUFA3/NDUFB11/NDUFB6/GNAI3	2.48046571698869
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	38/1042	238/9376	1.43666833336022	RASGRF2/RASAL3/RASSF5/PRKCB/GNG2/ETS1/FASLG/PIK3CD/ZAP70/RASA3/FGF6/PDGFA/PDGFRA/GNB1/RAC2/PLD1/FGFR1/ETS2/PDGFD/PRKCG/GRIN2B/EFNA1/EFNA5/PLCG1/PDGFRB/REL/EFNA3/RGL1/PLCG2/PRKCA/CDC42/PLA2G10/KDR/GNB5/GNG5/KITLG/IGF1/VEGFA	2.41272236439166
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	20/1042	110/9376	1.6360146571279	DCN/NBL1/EMP3/BAMBI/IFNG/FBN1/SMAD3/TGFB2/SKP1/E2F5/ID2/SKI/TGFB1/NOG/THBS1/ACVR1B/FMOD/TGFBR2/LEFTY2/TNF	2.37252101779005
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	54/1042	368/9376	1.32037052491029	ACTB/TUBA1A/ATP5F1E/PFN1/TUBB6/MT-CO3/WDR41/ACTG1/MT-CO1/MT-CO2/NDUFS5/NDUFA4/MT-ND3/NXF3/NEFH/TUBB1/TUBA3E/COX7A1/MT-ND4/GPX8/MT-ATP6/COX7A2/CCS/MT-ND1/GRIN2B/SOD1/UQCR11/UQCRH/MT-ND2/NDUFB2/NDUFB10/NRG1/NDUFA1/TUBB/PSMB4/NOS2/UQCRQ/UQCRB/ULK2/COX6C/NDUFB7/TUBA1B/COX5B/NDUFA3/NUP93/COX6B1/GPX7/NDUFB11/NDUFB6/PPP3CA/TNF/ATP5MC2/APAF1/PSMB5	2.21694553155881
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	46/1042	308/9376	1.34386918264078	HIP1/TUBA1A/ATP5F1E/TUBB6/MT-CO3/POLR2L/MT-CO1/MT-CO2/NDUFS5/NDUFA4/CREB3L3/MT-ND3/TUBB1/TUBA3E/COX7A1/MT-ND4/GPX8/MT-ATP6/COX7A2/MT-ND1/GRIN2B/SOD1/UQCR11/UQCRH/MT-ND2/NDUFB2/NDUFB10/NDUFA1/TUBB/PSMB4/UQCRQ/UQCRB/ULK2/COX6C/GRIA4/NDUFB7/TUBA1B/COX5B/NDUFA3/COX6B1/GPX7/NDUFB11/NDUFB6/ATP5MC2/APAF1/PSMB5	2.16972957354882
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	39/1042	254/9376	1.38159505493675	PTK2B/F2R/PLN/PRKCB/CD38/PTGER3/P2RX1/P2RX6/P2RX7/SLN/FGF6/PDGFA/PDGFRA/NFATC2/CAMK2D/CAMK1D/FGFR1/ATP2A3/PDGFD/CAMK4/PRKCG/GRIN2B/PLCG1/ASPH/PDGFRB/MST1R/NOS2/GNA14/CXCR4/PLCG2/RYR1/PRKCA/KDR/EDNRA/TBXA2R/VEGFA/PPP3CA/CHRFAM7A/PDE1A	2.18005430535733
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	25/1042	149/9376	1.50974506949722	PTK2B/F2R/PIK3CG/AGPAT4/PIK3R5/PIK3CD/LPAR2/PDGFA/PDGFRA/FYN/CYTH4/LPAR1/AGPAT2/PLD1/PLPP1/FCER1G/PDGFD/LPAR6/PLCG1/PDGFRB/RAPGEF4/SYK/PLCG2/PRKCA/KITLG	2.2177299280815
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	15/1042	78/9376	1.73040011811605	SERPING1/C1R/CFL1/ITGB1/C3/ITGAM/C1QC/NOS2/PYCARD/C1QA/C5/TNF/IL6/NLRP3/GNAI3	2.29037246959257
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	19/1042	106/9376	1.61286350631949	ZEB1/TCF7L2/PIK3CD/IL1R2/LEF1/CREB3L3/FOLR2/PDGFA/PDGFRA/HSP90AB1/FGFR1/FOXO1/PDGFD/RB1/PDGFRB/TCF7L1/TCF7/HSP90B1/IGF1	2.24372474047361
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	26/1042	157/9376	1.49012799980439	ACTB/CCND2/ACTG1/TCF7L2/CCND3/WNT10B/LEF1/FZD2/WNT9B/SMAD3/TGFB2/LLGL2/YWHAH/WNT6/WNT4/ID2/WNT9A/PARD6G/TCF7L1/TCF7/TGFB1/PATJ/BIRC3/TGFBR2/CRB2/YWHAQ	2.18982889351218
Human Diseases	Infectious disease: viral	hsa05162	Measles	23/1042	136/9376	1.5217342215197	IL2RB/CD3D/CD3E/CCND2/CCND3/MX1/FASLG/PIK3CD/MSN/OAS3/SLAMF1/IKBKE/RACK1/CLEC4M/IRF7/STAT1/OAS1/OAS2/JAK3/IL2RA/IL6/APAF1/STAT2	2.16708298390975
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	12/1042	59/9376	1.83011809102443	GSTA1/GSTO1/GSTM5/NAT8/GPX8/MGST1/GSTO2/GSTM4/IDH2/GPX7/GPX4/OPLAH	2.26162494885534
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	20/1042	115/9376	1.56488358507886	PIK3CG/PRKCB/KCNQ5/GNG2/PIK3R5/KCNQ3/PIK3CD/CREB3L3/KCNQ1/CAMK2D/FYN/GNB1/CAMK4/PRKCG/PRKCA/GNB5/GNG5/GNAO1/CHRFAM7A/GNAI3	2.15512111753173
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	18/1042	101/9376	1.60361832728378	PRKCB/TCF7L2/WNT10B/LEF1/CREB3L3/FZD2/WNT9B/CAMK2D/PRKCG/WNT6/WNT4/WNT9A/TCF7L1/TCF7/PRKCA/GNAO1/KITLG/GNAI3	2.15654683732861
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	12/1042	60/9376	1.79961612284069	PRKCB/PIK3CD/NFATC2/RAC2/PRKCG/PLCG1/PLCG2/PRKCA/CDC42/KDR/VEGFA/PPP3CA	2.1970259024855
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	13/1042	67/9376	1.74589623857679	GAPDH/PKLR/ENO2/ENO1/LDHA/ENO4/GALM/ALDH3B1/AKR1A1/ALDH3A2/ADH1B/PFKP/PGK1	2.1664918164781
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	16/1042	89/9376	1.61763246996916	TUBA1A/TUBB6/PRKCB/TUBB1/PDGFA/PDGFRA/TUBA3E/LPAR1/GJA1/PDGFD/PRKCG/PDGFRB/TUBB/PRKCA/TUBA1B/GNAI3	2.0700467309098
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	14/1042	75/9376	1.67964171465131	PYCR1/GAPDH/PKLR/ENO2/ARG1/ENO1/ENO4/GPT/PRPS1/MAT2A/PFKP/PGK1/IDH2/PHGDH	2.08948176802146
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	27/1042	170/9376	1.42910692107937	MYL9/ACTB/MYL6/TUBA1A/JAM2/ACTG1/ITGB1/CLDN5/MSN/CD1D/TUBA3E/ARHGEF2/RUNX1/ACTN1/VASP/RAB8B/HCLS1/LLGL2/MYL12A/MPDZ/F11R/PARD6G/ARPC3/CDC42/PATJ/TUBA1B/ARPC1B	1.9963985435981
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	16/1042	90/9376	1.59965877585839	LCK/CD3D/CD3E/CD247/PDCD1/PIK3CD/ZAP70/IFNG/NFATC2/PRKCQ/PLCG1/BATF/IFNGR2/STAT1/MAP3K3/PPP3CA	2.02117472420428
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	13/1042	69/9376	1.6952905505021	LCP2/PIK3CD/FYN/VAV1/RAC2/FCER1G/PLCG1/SYK/PLCG2/PRKCA/BTK/VAV2/TNF	2.04964555517667
Human Diseases	Cancer: specific types	hsa05214	Glioma	14/1042	76/9376	1.65754116577432	PRKCB/PIK3CD/PDGFA/PDGFRA/CAMK2D/CAMK1D/CAMK4/PRKCG/RB1/PLCG1/PDGFRB/PLCG2/PRKCA/IGF1	2.0350778095401
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	34/1042	226/9376	1.35369354372972	MYL9/F2R/PDE4A/PLN/FXYD2/PTGER3/PIK3CD/CREB3L3/CNGA4/EDN2/NPR1/FXYD1/CAMK2D/VAV1/RAC2/PTGER2/GIPR/PLD1/ATP2A3/HCAR2/ADCY10/CAMK4/GRIN2B/GABBR1/RAPGEF4/GLP1R/SUCNR1/SSTR2/GRIA4/EDNRA/VAV2/FSHR/ATP1B2/GNAI3	1.90310852417006
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	25/1042	157/9376	1.4328153844273	HLA-B/HLA-A/IGFBP3/HLA-C/HLA-G/HLA-E/RASSF5/CCND2/ETS1/CCND3/PIK3CD/SMAD3/NFATC2/TGFB2/CAPN2/HLA-F/FOXO1/EIF4EBP1/RB1/E2F5/TGFB1/PPP3CA/TGFBR2/IL6/CHEK2	1.93376349597196
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	14/1042	78/9376	1.61504011024165	FN1/ACTB/ACTG1/ITGB1/PIK3CD/CAV1/CBL/ARHGAP10/HCLS1/CAV2/ARPC3/CDC42/ARPC1B/RHOG	1.92862911882611
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	20/1042	122/9376	1.4750951826563	ACTB/PLN/FXYD2/PRKCB/ACTG1/PIK3CD/TBC1D4/SLCO1C1/ATP2A3/FOXO1/PRKCG/PLCG1/WNT4/ESR1/PLCG2/STAT1/PRKCA/NCOA1/PFKP/ATP1B2	1.86762012092309
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	16/1042	93/9376	1.54805687986296	MYL9/ACTB/ACTG1/TCF7L2/LEF1/SMAD3/FYN/RAC2/FGFR1/ACTN1/MYL12A/TCF7L1/TCF7/CDC42/NECTIN2/TGFBR2	1.8780868963665
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	21/1042	130/9376	1.45353609921748	MMP2/ACTA2/COL1A2/GNG2/RXFP1/PIK3CD/CREB3L3/COL4A1/GNB1/COL3A1/COL4A2/NOS2/PRKCA/TGFB1/GNB5/GNG5/GNAO1/VEGFA/TGFBR2/COL1A1/GNAI3	1.84119311271732
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	12/1042	65/9376	1.66118411339141	GPAT2/AGPAT4/LCLAT1/AGPAT2/GPAM/PLPP1/LIPC/AKR1A1/ALDH3A2/DGAT2/MBOAT1/MGLL	1.89135771204347
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	25/1042	163/9376	1.38007371383489	PTK2B/PRKCB/FASLG/PIK3CD/CREB3L3/SMAD3/NFATC2/CASP10/IKBKE/TGFB2/PRKCG/RB1/IRF7/STAT1/PRKCA/HSPG2/TGFB1/JAK3/TGFBR2/TNF/IL6/EGR3/APAF1/YWHAQ/STAT2	1.73082775492801
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	4/1042	14/9376	2.5708801754867	CHST2/B3GNT7/CHST1/B4GALT4	2.07977095125834
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	28/1042	187/9376	1.34730618822298	TXNIP/ANTXR1/CYBA/PSTPIP1/TXN/P2RX7/HSP90AB1/CTSB/OAS3/NAIP/IKBKE/NLRP1/GBP5/CCL5/IFI16/ANTXR2/IRF7/STAT1/NLRX1/OAS1/OAS2/PYCARD/TRAF5/BIRC3/TNF/IL6/NLRP3/STAT2	1.69625815524144
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	17/1042	105/9376	1.45683209944246	PIK3CD/NFATC2/LSP1/IKBKE/FCER1G/CLEC4M/CLEC1B/SYK/PLCG2/STAT1/PYCARD/PPP3CA/TNF/IL6/EGR3/NLRP3/STAT2	1.66448820031973
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	15/1042	91/9376	1.48320010124233	CD22/CD81/PRKCB/CARD11/PIK3CD/LILRA1/NFATC2/BANK1/VAV1/RAC2/SYK/PLCG2/BTK/VAV2/PPP3CA	1.63775716596307
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	29/1042	201/9376	1.29823053637761	IGFBP3/ZBTB16/IL2RB/WT1/PAX8/ZEB1/NUPR1/CCND2/IL1R2/TRAF1/PDGFA/GZMB/ITGAM/RUNX1/BCL11B/MLLT3/FOXO1/KMT2A/TSPAN7/ITGB7/MYCN/REL/ID2/FLI1/BIRC3/IGF1/MAF/TGFBR2/IL6	1.51126231016552
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	5/1042	22/9376	2.04501832140988	AOC1/MAOB/ALDH3B1/ALDH3A2/AMDHD1	1.73511918546809
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	17/1042	109/9376	1.40337037102256	GYS1/PRKCB/PIK3CD/TBC1D4/CREB3L3/PRKCQ/FOXO1/MLXIP/SLC27A1/PPARGC1B/RPS6KA3/RPS6KA1/TNF/PPP1R3C/IL6/SOCS3/IRS2	1.49775373633698
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	7/1042	36/9376	1.74962678609512	GALNT15/GALNT3/GALNT5/GALNT7/GCNT1/GALNT6/B4GALT5	1.59336641370067
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	23/1042	158/9376	1.30984717801696	RPS6/PRKCB/WNT10B/PIK3CD/FZD2/WNT9B/EIF4E1B/DEPTOR/DDIT4/LAMTOR2/EIF4EBP1/PRKCG/WNT6/WNT4/WNT9A/ULK2/LAMTOR5/PRKCA/TBC1D7/RPS6KA3/IGF1/RPS6KA1/TNF	1.38883446813912
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	12/1042	73/9376	1.47913653932112	PPIA/MX1/BICD1/CCR5/BST2/MLLT3/FEZ1/MAP1B/APOBEC3G/CXCR4/MDFIC/PIN1	1.45312160850523
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	8/1042	44/9376	1.6360146571279	TMEM258/DAD1/MGAT2/MAN1A1/MGAT4A/MGAT4C/MAN2A1/RPN1	1.49519848043654
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	4/1042	17/9376	2.11719543863611	CYP27A1/CYP8B1/CYP39A1/CYP7B1	1.6301652853961
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	7/1042	38/9376	1.65754116577432	FXYD2/PRKCB/PIK3CD/PRKCG/PRKCA/IGF1/ATP1B2	1.43608637039955
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	12/1042	75/9376	1.43969289827255	FASLG/GSTA1/PIK3CD/GSTO1/GSTM5/MGST1/GSTO2/BRCA1/GSTM4/BIRC3/MSH2/APAF1	1.35178620538377
Human Diseases	Substance dependence	hsa05032	Morphine addiction	14/1042	91/9376	1.38432009449284	PDE4A/PRKCB/GNG2/GNB1/PRKCG/GABBR1/GABRA2/PRKCA/PDE2A/GNB5/GNG5/GNAO1/PDE1A/GNAI3	1.30261352835187
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	22/1042	154/9376	1.28544008774335	MYL9/ACTB/MYL6/PIK3CG/PRKCB/CD38/ACTG1/PIK3R5/CACNB2/NPR1/NFATC2/CAMK2D/CAMK1D/CAMK4/PRKCG/EEF2/CACNG5/RYR1/PRKCA/GNAO1/PPP3CA/GNAI3	1.26286090064609
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	34/1042	253/9376	1.20922822483367	MYL9/ACTB/PFN1/ACTG1/ITGB1/C3/PIK3CD/RPS27A/FNBP1/ARHGEF2/PRKCQ/UBA52/NAIP/CYTH4/CAPN2/CD44/FOXO1/ACTN1/HCLS1/CCL5/SKP1/PLCG1/MYL12A/PLCG2/UBB/ARPC3/CDC42/UBC/BNIP3/PYCARD/TRAF5/ARPC1B/TNF/NLRP3	1.19290111121192
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	11/1042	69/9376	1.43447661965562	PRKCB/MAOB/CREB3L3/CAMK2D/CAMK4/PRKCG/GRIN2B/PRKCA/GRIA4/PPP3CA/SLC18A2	1.28079271559529
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	3/1042	12/9376	2.24952015355086	NCAM1/SLAMF1/CLEC4M	1.53142571538008
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	12/1042	77/9376	1.4022982775382	PIK3CD/SMAD3/RAC2/TGFB2/PLD1/RB1/STAT1/CDC42/TGFB1/ARHGEF6/VEGFA/TGFBR2	1.25333786786091
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	5/1042	26/9376	1.73040011811605	ABCC1/RBP2/PLB1/CUBN/APOA1	1.31866491992844
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	10/1042	63/9376	1.42826676415928	TCF7L2/WNT10B/LEF1/FZD2/WNT9B/WNT6/WNT4/WNT9A/TCF7L1/TCF7	1.20595914430835
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	9/1042	56/9376	1.44612009871127	ST6GAL1/TMEM258/DAD1/MGAT2/MAN1A1/MGAT4A/MGAT4C/MAN2A1/RPN1	1.18394246143844
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	9/1042	56/9376	1.44612009871127	EEF1A1/C3/ITGAM/NAIP/BNIP3/PYCARD/TNF/IL6/APAF1	1.18394246143844
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	20/1042	144/9376	1.24973341863937	IL6ST/WNT10B/PIK3CD/JARID2/FZD2/WNT9B/SMAD3/FGFR1/WNT6/WNT4/ID2/LIF/WNT9A/TCF7/ACVR1B/JAK3/IGF1/ZFHX3/HESX1/LEFTY2	1.06783157896803
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	13/1042	89/9376	1.31432638184994	PRKCB/GNG2/GNB1/PRKCG/GABBR1/GABRA2/PRKCA/GNB5/GNG5/GNAO1/PLCL1/SLC12A5/GNAI3	1.05349108219597
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	14/1042	97/9376	1.29869204741081	PRKCB/GNG2/CAMK2D/GNB1/ADCY10/PRKCG/GRIN2B/RYR1/PRKCA/GRIA4/GNB5/GNG5/GNAO1/GNAI3	1.04556657031445
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	4/1042	21/9376	1.71392011699113	ALDH3A2/ENPP1/PANK2/DPYD	1.15805749274011
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	8/1042	51/9376	1.4114636257574	ACTB/ACTG1/ATP6V0E1/KCNQ1/SEC61G/PLCG1/PLCG2/PRKCA	1.04180123069861
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	21/1042	156/9376	1.21128008268123	CD81/MX1/FASLG/CLDN5/PIK3CD/IFNG/OAS3/IKBKE/RB1/IFIT1/YWHAH/LDLR/IRF7/STAT1/OAS1/OAS2/TNF/APAF1/YWHAQ/SOCS3/STAT2	0.940910134719167
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	14/1042	99/9376	1.27245584443281	PRKCB/PIK3CD/SLC22A2/PDGFA/PDGFRA/RAC2/PLD1/PLPP1/EIF4EBP1/PDGFD/PRKCG/PLCG1/PDGFRB/PRKCA	0.963613103391344
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	20/1042	148/9376	1.21595683975722	TCF7L2/WNT10B/PIK3CD/LEF1/FGF6/FZD2/WNT9B/DLL3/FGFR1/JAG2/RB1/WNT6/WNT4/ESR1/WNT9A/BRCA1/TCF7L1/TCF7/NCOA1/IGF1	0.936346901990962
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	12/1042	83/9376	1.30092731771616	ZDHHC11B/CCL4L2/POLR2L/IKBKE/ZBP1/CCL5/IFI16/CCL4/IRF7/PYCARD/IL6/NLRP3	0.973678188321092
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	8/1042	52/9376	1.38432009449284	NPC2/TSPO/SOAT1/LIPC/CYP27A1/LDLR/APOE/APOA1	0.9826217695721
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	38/1042	300/9376	1.1397568777991	FLNA/RASGRF2/MAP3K21/PRKCB/PTPN7/FASLG/CACNB2/FGF6/PDGFA/PDGFRA/DUSP2/MECOM/RAC2/TGFB2/FGFR1/PDGFD/PRKCG/EFNA1/EFNA5/PDGFRB/EFNA3/CACNG5/DUSP10/PRKCA/CDC42/TGFB1/KDR/MAP3K3/MAP4K1/KITLG/RPS6KA3/IGF1/RPS6KA1/MAPK8IP3/VEGFA/PPP3CA/TGFBR2/TNF	0.869920015145307
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	28/1042	216/9376	1.16641785739674	CYBA/TNFSF10/FASLG/PIK3CD/CCL3L1/HSP90AB1/ARHGEF1/NFATC2/CAMK2D/VAV1/IKBKE/CCL5/PLCG1/CD40LG/LDLR/IRF7/PRKCA/CDC42/ICAM1/PYCARD/HSP90B1/VAV2/PPP3CA/APOA1/TNF/IL6/NLRP3/APAF1	0.874926991252724
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	10/1042	68/9376	1.32324714914757	ZBTB16/TCF7L2/PIK3CD/LEF1/ITGAM/RUNX1/PIM2/EIF4EBP1/TCF7L1/TCF7	0.945918505781174
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	11/1042	76/9376	1.30235377310839	ACTB/PRKCB/ACTG1/KCNQ1/CAMK2D/PRKCG/SSTR2/PRKCA/ATP1B2/KCNJ16/GNAI3	0.935779364564989
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	13/1042	93/9376	1.25779621488865	FN1/ITGB1/PIK3CD/TRAF1/COL4A1/RB1/LAMA1/COL4A2/NOS2/TRAF5/BIRC3/APAF1/LAMC1	0.883418694125924
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	19/1042	143/9376	1.19554917251654	HLA-DRB5/C1R/HLA-DQA1/HLA-DRB1/HLA-DPA1/C3/IFNG/C1QC/HLA-DPB1/SNRPD1/ACTN1/GRIN2B/HLA-DQB1/HLA-DOA/CD40LG/HLA-DRA/C1QA/C5/TNF	0.833192463793777
Cellular Processes	Cell motility	hsa04814	Motor proteins	25/1042	194/9376	1.15954647090251	MYL9/TPM2/ACTB/ACTA2/MYL6/TUBA1A/MYO1F/TPM1/TUBB6/KIF12/ACTG1/ACTG2/MYO5A/MYO10/KIF19/TUBB1/TUBA3E/BICDL1/MYL12A/TUBB/KIF3C/MYO1G/DYNLL1/TUBA1B/TNNI2	0.793984771126889
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	16/1042	120/9376	1.19974408189379	ARHGDIB/FASLG/PIK3CD/MATK/CAMK2D/IRAK3/CAMK4/MAGED1/PLCG1/IRAK2/PLCG2/ARHGDIA/CDC42/MAP3K3/RPS6KA3/RPS6KA1	0.778655974790995
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	12/1042	87/9376	1.24111456747634	TCF7L2/PIK3CD/LEF1/SMAD3/RAC2/TGFB2/APPL1/TCF7L1/TCF7/TGFB1/MSH2/TGFBR2	0.798898019514302
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	8/1042	55/9376	1.30881172570232	UGCG/CERS6/B4GALNT1/PSAP/PLPP1/B4GALT5/SPTLC2/SMPD1	0.812150699479647
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	26/1042	205/9376	1.141219980338	HLA-B/HLA-A/HLA-C/HLA-G/HLA-E/CCND2/IL6ST/CCND3/C3/PIK3CD/TRAF1/CREB3L3/CCR4/CCR5/HLA-F/ACTN1/RB1/YWHAH/REL/SYK/IRF7/CDC42/TRAF5/JAK3/EGR3/YWHAQ	0.722865470585823
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	4/1042	24/9376	1.49968010236724	EXTL3/HS3ST2/EXT1/HS3ST5	0.866638896721026
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	31/1042	250/9376	1.11576199616123	HLA-B/HLA-A/HLA-C/HLA-G/IL2RB/HLA-E/CAV1/WIPF1/FOLR2/PDGFRA/CCR5/SMAD3/ASAP3/CYTH4/ACAP1/PLD1/HLA-F/CBL/CHMP5/LDLR/CXCR4/CAV2/PARD6G/ARPC3/CDC42/RAB11FIP3/BIN1/ARPC1B/IL2RA/TGFBR2/IGF2R	0.655976873761537
NA	NA	hsa04082	Neuroactive ligand signaling	25/1042	199/9376	1.13041213746275	TAC3/PRKCB/GNG2/P2RX1/HTR3E/P2RX6/P2RY13/HTR3A/GNB1/ADRA2C/PRKCG/GRIN2B/GABBR1/GABRA2/ADRA2A/SLC1A1/PRKCA/GRIA4/GNB5/GNG5/GNAO1/SLC17A9/SLC18A2/CHRFAM7A/GNAI3	0.657486643909872
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	15/1042	115/9376	1.17366268880915	PRKCB/MAOB/GNG2/KCND2/HTR3E/HTR3A/GNB1/PRKCG/PRKCA/GNB5/GNG5/GNAO1/ALOX12/SLC18A2/GNAI3	0.662550900514629
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	15/1042	115/9376	1.17366268880915	PTH1R/PDE4A/PRKCB/MEF2A/CREB3L3/MMP25/ARHGEF1/PLD1/FGFR1/STK39/PRKCG/PTHLH/PRKCA/HBEGF/GNAI3	0.662550900514629
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	27/1042	217/9376	1.11957685061518	PRKCB/CCND3/GSTA1/PIK3CD/GSTO1/CREB3L3/GSTM5/FGF6/DLL3/HSP90AB1/IKBKE/MGST1/EIF4EBP1/PRKCG/RB1/GSTO2/ESR1/PRKCA/GSTM4/HSP90B1/AIP/RPS6KA3/RPS6KA1/VEGFA/NR1I3/CHRFAM7A/GNAI3	0.630152549858432
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	11/1042	82/9376	1.20705959458827	CES1/GSTA1/GSTO1/TYMP/GSTM5/MGST1/GSTO2/GSTM4/TPMT/DPYD/HPRT1	0.665876519894751
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	6/1042	41/9376	1.31679228500538	MMP2/TYMP/RB1/THBS1/VEGFA/HBEGF	0.718790143735548
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	17/1042	133/9376	1.150130604823	PRKCB/MAOB/GNG2/CREB3L3/CAMK2D/GNB1/PRKCG/GRIN2B/PPP2R5D/PRKCA/GRIA4/GNB5/GNG5/GNAO1/PPP3CA/SLC18A2/GNAI3	0.616568492353339
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	21/1042	168/9376	1.12476007677543	FTL/FTH1/TNFSF10/PPIA/FASLG/IFNG/HSP90AB1/CAMK2D/ZBP1/CAPN2/CHMP5/IFNGR2/STAT1/PYCARD/TRAF5/BIRC3/JAK3/SMPD1/TNF/NLRP3/STAT2	0.576952910471578
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	21/1042	168/9376	1.12476007677543	PRL/IL2RB/CCND2/IL6ST/CCND3/PIK3CD/IFNG/PDGFA/PDGFRA/IL7/PDGFRB/LIF/IL10RA/IFNGR2/STAT1/JAK3/IL2RA/IL27RA/IL6/SOCS3/STAT2	0.576952910471578
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	17/1042	134/9376	1.1415475406079	MYL9/RAMP1/ACTA2/MYL6/PRKCB/ACTG2/ADM2/EDN2/NPR1/ARHGEF1/PPP1R14A/PRKCQ/PRKCG/PRKCA/PLA2G10/EDNRA/KCNMB1	0.583531754818537
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	10/1042	75/9376	1.19974408189379	PAX8/FXYD2/PRKCB/CREB3L3/GPX8/PRKCG/PRKCA/HSP90B1/GPX7/ATP1B2	0.614090642746074
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	14/1042	109/9376	1.15571677613622	CCL4L2/PIK3CD/CCL3L1/IKBKE/CCL5/CCL4/CXCL9/IRF7/STAT1/SPP1/TNF/IL6/CTSK/STAT2	0.578191657154052
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	9/1042	67/9376	1.20869739593778	PRKCB/CAMK2D/CAMK4/PRKCG/GRIN2B/PRKCA/RPS6KA3/RPS6KA1/PPP3CA	0.606171712679761
NA	NA	hsa04519	Cadherin signaling	48/1042	404/9376	1.06907888485586	ACTB/PTK2B/VIM/CDH11/MYO1F/LHFPL6/ACTG1/TCF7L2/WNT10B/CTNND2/LEF1/VANGL1/DES/ARHGAP35/FZD2/WNT9B/CDH16/KRT26/PDGFRA/VAV1/RAC2/FGFR1/EVL/GJA1/ACTN1/VASP/PDGFRB/YWHAH/WNT6/WNT4/GABRA2/CELSR1/MPDZ/TMC8/WNT9A/TCF7L1/TCF7/ARPC3/CDC42/MYO1G/KDR/ARPC1B/VAV2/LIMA1/CDH13/BRK1/CDH23/YWHAQ	0.501861774462835
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	7/1042	51/9376	1.23503067253773	PLA2G7/LPCAT2/ENPP2/PLD1/PLPP1/PLA2G10/PLB1	0.595083571363102
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	6/1042	43/9376	1.25554613221444	AGPAT2/PLPP1/SLC27A1/DGAT2/PLA2G10/APOA1	0.593862164183399
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	13/1042	102/9376	1.14681419592789	FXYD2/PRKCB/CD38/CELA3B/SLC4A4/KCNQ1/ATP2A3/PRKCG/CPB1/PRKCA/PLA2G10/ATP1B2/CPB2	0.527141660942701
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	11/1042	86/9376	1.15091728786323	PRKCB/PIK3CD/CAMK2D/EIF4EBP1/CBL/PRKCG/PLCG1/NRG1/PLCG2/PRKCA/HBEGF	0.49713359214553
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	11/1042	86/9376	1.15091728786323	FXYD2/PRKCB/CREB3L3/SNAP25/CAMK2D/PRKCG/RAPGEF4/GLP1R/PRKCA/KCNMB1/ATP1B2	0.49713359214553
Organismal Systems	Digestive system	hsa04978	Mineral absorption	8/1042	61/9376	1.18007614612504	FTL/FTH1/FXYD2/MT1X/HEPH/ATP1B2/SLC5A1/MT2A	0.498910248384905
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	7/1042	53/9376	1.18842574149857	PTH1R/FXYD2/PRKCB/PRKCG/ESR1/PRKCA/ATP1B2	0.486399450138473
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	15/1042	122/9376	1.10632138699223	IGFBP3/PRKCB/PIK3CD/CREB3L3/ADCY10/PRKCG/PLCG1/SSTR2/PLCG2/STAT1/PRKCA/IGF1/GNAI3/SOCS3/IRS2	0.417954062427917
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	10/1042	79/9376	1.1389975461017	HSD11B1/GSTA1/GSTO1/GSTM5/CYP2S1/MGST1/ALDH3B1/GSTO2/ADH1B/GSTM4	0.438674119414964
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	6/1042	45/9376	1.19974408189379	ABCC1/DEFB1/TAP1/ABCC6/ABCA7/ABCA2	0.474907285943114
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	20/1042	166/9376	1.0841060980968	MYL9/PLN/FXYD2/PIK3CG/PIK3R5/MEF2A/CREB3L3/NPR1/NFATC2/ATP2A3/ADRA2C/VASP/ADRA2A/PDE2A/EDNRA/KCNMB1/PPP3CA/ATP1B2/GNAI3/IRS2	0.386584523854794
NA	NA	hsa04081	Hormone signaling	26/1042	219/9376	1.06826527839858	PRL/RAMP1/PTH1R/GNG2/PIK3CD/SLCO1C1/NPR1/GNB1/HEPH/GIPR/ADRA2C/RAPGEF4/ESR1/GLP1R/ADRA2A/PTHLH/SSTR2/GNA14/APPL1/GNB5/GNG5/GNAO1/IGF1/FSHR/GNAI3/IRS2	0.361441541382843
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	5/1042	37/9376	1.21595683975722	PAX8/TCF7L2/LEF1/TCF7L1/TCF7	0.465382863479261
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	8/1042	63/9376	1.14261341132742	MECOM/KMT2A/PLOD1/PLOD2/PIPOX/ALDH3A2/SMYD3/SMYD1	0.401586025076999
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	6/1042	46/9376	1.17366268880915	PSMB8/PSMB9/POMP/IFNG/PSMB4/PSMB5	0.41748162427173
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	9/1042	72/9376	1.12476007677543	ISG15/RNF125/CASP10/IKBKE/IRF7/NLRX1/DHX58/PIN1/TNF	0.375750684423561
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	14/1042	116/9376	1.0859752465418	PRKCB/GNG2/GNB1/PLD1/PRKCG/GRIN2B/SLC1A1/PRKCA/GRIA4/GNB5/GNG5/GNAO1/PPP3CA/GNAI3	0.329450128113543
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	15/1042	125/9376	1.07976967370441	ABCC1/PRKCB/PIK3CD/CERS6/FYN/RAC2/PLD1/FCER1G/PRKCG/PPP2R5D/PRKCA/SPTLC2/SMPD1/TNF/GNAI3	0.317461622277429
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	9/1042	73/9376	1.10935240449084	MAOB/GSTA1/GSTO1/GSTM5/MGST1/ALDH3B1/GSTO2/ADH1B/GSTM4	0.331643130646615
Human Diseases	Cancer: specific types	hsa05218	Melanoma	9/1042	73/9376	1.10935240449084	PIK3CD/FGF6/PDGFA/PDGFRA/FGFR1/PDGFD/RB1/PDGFRB/IGF1	0.331643130646615
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	9/1042	73/9376	1.10935240449084	RASSF5/PRKCB/PIK3CD/PRKCG/RB1/PLCG1/PLCG2/PRKCA/JAK3	0.331643130646615
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	4/1042	30/9376	1.19974408189379	ABCC1/FOLR2/TNF/IL6	0.387448879580563
NA	NA	hsa03272	Virion - Hepatitis viruses	6/1042	48/9376	1.12476007677543	CD9/CD81/CLDN5/CD63/LDLR/HSPG2	0.306404213335841
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	6/1042	48/9376	1.12476007677543	FXYD2/PRKCB/PIK3CD/GNAT3/ATP1B2/SLC5A1	0.306404213335841
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	9/1042	75/9376	1.07976967370441	IGFBP3/CCND2/CCND3/CD82/CCNG2/THBS1/IGF1/APAF1/CHEK2	0.245242861427228
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	4/1042	31/9376	1.16104265989722	SMOX/ALDH3B1/ALDH3A2/DPYD	0.31755933128853
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	18/1042	155/9376	1.0449383939075	TCF7L2/WNT10B/LEF1/CREB3L3/FZD2/WNT9B/CAMK2D/KMT2A/RB1/WNT6/WNT4/CYP17A1/LDLR/WNT9A/TCF7L1/TCF7/AIP/GNAI3	0.199474384840607
Organismal Systems	Digestive system	hsa04970	Salivary secretion	11/1042	93/9376	1.06428910490578	CST3/FXYD2/PRKCB/CD38/MUC5B/BEST2/PRKCG/PRKCA/LYZ/CST2/ATP1B2	0.220306559298875
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	6/1042	49/9376	1.1018057894943	GALNT15/GALNT3/ST6GAL1/GALNT5/GALNT7/GALNT6	0.252634278660337
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	3/1042	23/9376	1.17366268880915	ARG1/GPT/NOS2	0.294840895343234
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	3/1042	23/9376	1.17366268880915	PRCP/ATP6AP2/CTSA	0.294840895343234
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3/1042	23/9376	1.17366268880915	FXYD2/SLC4A4/ATP1B2	0.294840895343234
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	18/1042	157/9376	1.03162707678766	MFGE8/GPR132/ARG1/DUSP2/ATP8A1/NFATC2/CAMK2D/C1QC/PTGER2/STAB2/ATP2A3/ANO9/XKR6/AXL/TGFB1/THBS1/C1QA/ATP11B	0.141305713190392
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	9/1042	77/9376	1.05172370815365	PIK3CD/MECOM/SMAD3/RUNX1/TGFB2/CBL/RB1/TGFB1/TGFBR2	0.161142330739908
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	12/1042	104/9376	1.03824007086963	GPAT2/AGPAT4/LPCAT2/LCLAT1/AGPAT2/GPAM/PLD1/PLPP1/MBOAT1/PLA2G10/PLB1/PEMT	0.138656871255329
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	16/1042	140/9376	1.02835207019468	ACTA2/RPS6/PIK3CG/GNG2/PIK3R5/MEF2A/SMAD3/GNB1/ADCY10/CAMK4/NOS2/RYR1/GNB5/GNG5/SPP1/GNAI3	0.119508716113502
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	17/1042	150/9376	1.01978246960972	TCF7L2/WNT10B/PIK3CD/LEF1/FGF6/FZD2/WNT9B/SMAD3/TGFB2/RB1/WNT6/WNT4/WNT9A/TCF7L1/TCF7/TGFB1/TGFBR2	0.0863599060582717
Organismal Systems	Endocrine system	hsa04924	Renin secretion	8/1042	69/9376	1.04325572338591	EDN2/NPR1/CTSB/PTGER2/EDNRA/PPP3CA/PDE1A/GNAI3	0.127513456223233
Organismal Systems	Nervous system	hsa04730	Long-term depression	7/1042	60/9376	1.04977607165707	PRKCB/PRKCG/RYR1/PRKCA/GNAO1/IGF1/GNAI3	0.136764774534623
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	5/1042	42/9376	1.07120007311946	AOC1/MAOB/IDO1/ALDH3A2/AFMID	0.163517386126273
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	5/1042	42/9376	1.07120007311946	FTL/FTH1/CP/SAT2/GPX4	0.163517386126273
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/1042	15/9376	1.19974408189379	ST3GAL5/B4GALNT1	0.273748140138218
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	15/1042	133/9376	1.01482112190265	TNFSF10/CCND2/FASLG/PIK3CD/SMAD3/TGFB2/FOXO1/CCNG2/BNIP3/TGFB1/SGK3/IGF1/TGFBR2/IL6/IRS2	0.0608685803755532
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	11/1042	98/9376	1.00998864036978	PRKCB/CREB3L3/NPR1/CAMK2D/CAMK1D/CAMK4/PRKCG/LDLR/PRKCA/PDE2A/ATP1B2	0.0351467344806328
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	8/1042	71/9376	1.01386823822011	JAM2/ATP6V0E1/CCL5/PLCG1/F11R/PLCG2/CDC42/HBEGF	0.0414748695135908
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	8/1042	71/9376	1.01386823822011	PIK3CD/PDGFRA/LDHA/FGFR1/PDGFRB/PDK1/PFKP/IDH2	0.0414748695135908
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	16/1042	144/9376	0.999786734911495	TCF7L2/FASLG/C3/LEF1/IL17RA/C1QC/IKBKE/FOXO1/ALDH3A2/ADH1B/TCF7L1/TCF7/C1QA/C5/TNF/IL6	-0.000911897163934723
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/1042	16/9376	1.12476007677543	MAOB/ALDH3B1	0.176599898618098
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	11/1042	99/9376	0.999786734911495	PRKCB/PIK3CD/PRKCQ/CAMK2D/PTGER2/PRKCG/PLCG1/PLCG2/PRKCA/IGF1/ALOX12	-0.000754269133800905
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	17/1042	154/9376	0.993294613256225	TPM2/TPM1/PLN/FXYD2/PIK3CG/PIK3R5/CACNB2/CREB3L3/KCNQ1/CAMK2D/ATP2A3/RAPGEF4/PPP2R5D/CACNG5/PRKCA/ATP1B2/GNAI3	-0.0296663682013623
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	13/1042	119/9376	0.982983596509621	PIK3CD/TRAF1/CREB3L3/LTA/CASP10/CCL5/LIF/ICAM1/TRAF5/BIRC3/TNF/IL6/SOCS3	-0.0660539621720744
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	5/1042	46/9376	0.978052240674289	FTL/FTH1/CP/HEPH/HMBS	-0.0527619736585609
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	7/1042	65/9376	0.969024066144987	PRKCB/PIK3CD/PRKCG/GABBR1/PRKCA/TRPC4/SPP1	-0.0886085587929793
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	21/1042	195/9376	0.969024066144987	ACTB/CYBA/FGG/PRKCB/ACTG1/C3/PIK3CD/FGB/FGA/GP1BA/ITGAM/ITGAL/RAC2/PRKCG/PLCG1/SYK/PLCG2/PRKCA/FPR3/VWF/C5	-0.154557281322786
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	40/1042	370/9376	0.972765471805779	PRL/TAC3/TSPO/CNR1/PTH1R/F2R/PTGER3/PTGDR/P2RX1/RXFP1/GZMA/C3/P2RX6/P2RX7/LPAR2/P2RY13/ADM2/EDN2/NPW/LPAR1/PTGER2/GIPR/ADRA2C/LPAR6/GRIN2B/GABBR1/GABRA2/GLP1R/ADRA2A/SSTR2/P2RY8/FPR3/GRIA4/EDNRA/TBXA2R/FSHR/C5/GPR83/P2RY10/CHRFAM7A	-0.188993773514513
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	6/1042	56/9376	0.964080065807513	GAS1/CCND2/BOC/CSNK1G3/EVC/SCUBE2	-0.0953266517814599
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	10/1042	94/9376	0.957242618532282	IL17RA/MUC5B/IFNG/HSP90AB1/IKBKE/IL17RE/TRAF5/HSP90B1/TNF/IL6	-0.147315008386732
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	5/1042	47/9376	0.957242618532282	PKLR/LDHA/AKR1A1/ALDH3A2/ADH1B	-0.103904709503418
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	5/1042	47/9376	0.957242618532282	PKLR/PIK3CD/TNF/SOCS3/IRS2	-0.103904709503418
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	3/1042	28/9376	0.964080065807513	PCBD1/ALPL/GCH1	-0.0673050956486534
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	4/1042	38/9376	0.947166380442469	NNMT/CD38/NNT/ENPP1	-0.115389948028724
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	4/1042	39/9376	0.922880062995226	MTHFD2/ALDH1L1/ALDH1L2/MAT2A	-0.170642827988906
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	5/1042	49/9376	0.918171491245251	MAOB/CREB3L3/GRIN2B/SLC18A2/GNAI3	-0.203060026210637
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	8/1042	78/9376	0.922880062995226	ENO2/ENO1/PABPC1/MPHOSPH6/PFKP/LSM5/PNPT1/NUDT16	-0.241830985772627
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	6/1042	59/9376	0.915059045512216	PTGER3/PIK3CD/NPR1/MGLL/GNAI3/IRS2	-0.231418377609487
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	7/1042	70/9376	0.899808061420346	HSD11B1/GSTA1/GSTO1/GSTM5/MGST1/GSTO2/GSTM4	-0.297504147934217
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	7/1042	70/9376	0.899808061420346	ETS1/PIK3CD/ELOB/TGFB2/CDC42/TGFB1/VEGFA	-0.297504147934217
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	9/1042	90/9376	0.899808061420346	PIK3CD/CREB3L3/EIF4E1B/FOXO1/EIF4EBP1/CAMK4/APPL1/IGF1/IRS2	-0.33770107597666
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	4/1042	41/9376	0.877861523336922	MAOB/PIPOX/GAMT/PHGDH	-0.277127750111725
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	4/1042	41/9376	0.877861523336922	GRIN2B/GABRA2/GRIA4/CHRFAM7A	-0.277127750111725
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	3/1042	31/9376	0.870781994922915	UGDH/AKR1A1/ALDH3A2	-0.254804430757079
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	3/1042	31/9376	0.870781994922915	SRPRB/SEC61G/UBL4A	-0.254804430757079
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	7/1042	71/9376	0.887134708442594	PRL/CCND2/PIK3CD/ESR1/CYP17A1/STAT1/SOCS3	-0.337539142727567
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	14/1042	139/9376	0.906281500711139	MMP2/GREB1/PIK3CD/CREB3L3/KRT26/HSP90AB1/FKBP5/GABBR1/ESR1/NCOA1/HSP90B1/GNAO1/HBEGF/GNAI3	-0.393604453403555
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/1042	21/9376	0.856960058495567	CSGALNACT2/CHST12	-0.232026626057901
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	6/1042	63/9376	0.856960058495567	PTGR1/PTGES/PLA2G10/PLB1/GPX4/ALOX12	-0.402787094154349
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	8/1042	83/9376	0.867284878477442	PRDX5/DECR2/SOD1/PECR/PIPOX/NOS2/FAR1/IDH2	-0.429412058923749
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	9/1042	93/9376	0.870781994922915	MMP2/PTK2B/PRKCB/CAMK2D/PLD1/PRKCA/CDC42/MAP3K3/HBEGF	-0.442805575528173
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	4/1042	44/9376	0.81800732856395	ARHGDIB/CREB3L3/ARHGDIA/DYNLL1	-0.427844174237398
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/1042	23/9376	0.782441792539431	POMGNT2/LARGE1	-0.369365792484292
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	25/1042	250/9376	0.899808061420346	NPC2/CTSC/CTSW/ATP6V0E1/CTSB/CD63/PSAP/CLN3/LAPTM5/DEPTOR/LAMTOR2/CTSL/OSBPL3/LAMTOR5/ARSG/AP1S1/CTSZ/GPR155/ABCA2/IGF2R/SMPD1/IDUA/OSBPL7/CTSK/CTSA	-0.567747592690547
Organismal Systems	Sensory system	hsa04742	Taste transduction	8/1042	86/9376	0.837030754809624	HTR3E/HTR3A/GABBR1/GABRA2/GNAT3/SCN9A/PKD2L1/PDE1A	-0.536833701544906
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	11/1042	116/9376	0.853266265139983	GAPDH/PKLR/ENO2/ENO1/ENO4/GPT/PRPS1/PFKP/PGK1/IDH2/PHGDH	-0.562271696711104
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	7/1042	78/9376	0.807520055120823	PLCH2/PIK3CG/PIK3CD/INPP4B/PLCG1/PLCG2/INPP5E	-0.603574336539084
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	15/1042	158/9376	0.854248159576277	CDKN1C/CCND2/CCND3/PTTG1/SMAD3/TGFB2/RB1/SKP1/YWHAH/E2F5/PPP2R5D/TGFB1/CDC14B/YWHAQ/CHEK2	-0.653306514103864
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/1042	36/9376	0.749840051183621	UGDH/AKR1A1/CRYL1	-0.53172654431604
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	3/1042	36/9376	0.749840051183621	GYS1/PGM2L1/ENPP1	-0.53172654431604
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	3/1042	37/9376	0.729574103854334	MAOB/ALDH3B1/ADH1B	-0.582762639278739
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	5/1042	59/9376	0.762549204593513	ENTPD3/TYMP/DHODH/ENPP1/DPYD	-0.646925598686958
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	5/1042	59/9376	0.762549204593513	TCF7L2/PIK3CD/LEF1/TCF7L1/TCF7	-0.646925598686958
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/1042	26/9376	0.69216004724642	PLA2G10/PLB1	-0.555774481109927
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	3/1042	38/9376	0.710374785331852	GNPDA2/UGDH/RENBP	-0.632548720838148
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	2/1042	27/9376	0.666524489940997	HACD4/ELOVL6	-0.613558528632278
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	16/1042	174/9376	0.827409711650892	TMEM258/SSR3/HSP90AB1/DAD1/SEC61G/FBXO6/CAPN2/LMAN2/SKP1/MAN1A1/SSR4/ERP29/OS9/HSP90B1/RPN1/SSR2	-0.812536003395542
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	13/1042	144/9376	0.81232672211559	PRKCB/ATXN1/BEAN1/PIK3CD/TRPC3/ATP2A3/PRKCG/GRIN2B/PSMB4/ULK2/RYR1/PRKCA/PSMB5	-0.80246950426291
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/1042	15/9376	0.599872040946897	ALPL	-0.548373116087256
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	5/1042	62/9376	0.725651662435763	PIK3CD/FOXO1/SOD1/IGF1/IRS2	-0.766342321850864
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	5/1042	62/9376	0.725651662435763	ATXN1/TLE6/DLL3/JAG2/NUMBL	-0.766342321850864
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	2/1042	28/9376	0.642720043871675	HACD4/ELOVL6	-0.669454500993857
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/1042	28/9376	0.642720043871675	FUT7/B4GALT4	-0.669454500993857
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	31/1042	323/9376	0.863592876285781	VIM/TIMP3/TNC/TPM1/ZEB1/ABCC1/PRKCB/CCND2/HOXD10/PIK3CD/ZEB2/PDGFA/PDGFRA/SOX4/TGFB2/CD44/DDIT4/PRKCG/EFNA1/EFNA5/PLCG1/PDGFRB/TRIM71/FSCN1/EFNA3/PLCG2/BRCA1/PRKCA/THBS1/VEGFA/IRS2	-0.882134488916887
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	4/1042	52/9376	0.69216004724642	CYP17A1/LDLR/IGF1/FSHR	-0.787078904939619
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/1042	16/9376	0.562380038387716	A3GALT2	-0.619458105921945
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/1042	29/9376	0.620557283738169	GUCA1A/GNB1	-0.723605481013074
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	11/1042	128/9376	0.773272552783109	PDE4A/ENTPD3/NPR1/ADA2/ADCY10/PRPS1/PDE2A/ENPP1/PDE1A/NUDT16/HPRT1	-0.91322527359398
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/1042	30/9376	0.599872040946897	PLA2G10/PLB1	-0.776138786962473
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	6/1042	76/9376	0.710374785331852	SLC27A1/CYP27A1/CYP8B1/UBC/FABP5/APOA1	-0.896384710393526
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/1042	17/9376	0.529298859659027	TXNRD1	-0.686827597252789
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/1042	17/9376	0.529298859659027	CLEC4M	-0.686827597252789
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	8/1042	98/9376	0.7345371929962	PRKCB/PIK3CD/INPP4B/PRKCG/PLCG1/PLCG2/PRKCA/INPP5E	-0.934076155197053
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	8/1042	99/9376	0.727117625390178	MMP2/PIK3CD/DLL3/JAG2/RB1/ESR1/IGF1/HBEGF	-0.965121641658945
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	2/1042	31/9376	0.58052132994861	PRPS1/PFKP	-0.827168192802687
NA	NA	hsa04981	Folate transport and metabolism	2/1042	31/9376	0.58052132994861	ABCC1/FOLR2	-0.827168192802687
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	12/1042	142/9376	0.760401178665081	RPS27A/ELOB/UBA52/UBE2L6/CBL/SKP1/UBB/BRCA1/UBC/UBE2S/BIRC3/SOCS3	-1.01724757680757
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	10/1042	122/9376	0.737547591328152	GYS1/PIK3CD/CREB3L3/FOXO1/EIF4EBP1/EEF2/PPP2R5D/PFKP/IGF1/IRS2	-1.03171199606725
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	2/1042	32/9376	0.562380038387716	GALM/PFKP	-0.876795773343251
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/1042	32/9376	0.562380038387716	BIRC3/APAF1	-0.876795773343251
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	13/1042	154/9376	0.759578233666525	DHRS3/MTHFD2/UGDH/IDO1/AKR1A1/ALDH3A2/HMBS/MAT2A/ALPL/DHODH/AFMID/PANK2/GCH1	-1.06368818327932
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/1042	19/9376	0.473583190221234	IDUA	-0.812140155450383
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	2/1042	33/9376	0.545338219042634	GPT/IDH2	-0.925113447468706
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	5/1042	70/9376	0.642720043871675	PRKCQ/APPL1/TNF/SOCS3/IRS2	-1.06088643885683
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/1042	34/9376	0.529298859659027	RORB/SKP1	-0.972204276526472
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/1042	20/9376	0.449904030710173	SOAT1	-0.87076527908543
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/1042	20/9376	0.449904030710173	UGDH	-0.87076527908543
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	14/1042	169/9376	0.745403127803837	WDR41/PIK3CD/RPS27A/CTSB/PRKCQ/UBA52/DEPTOR/DDIT4/CTSL/UBB/ULK2/UBC/BNIP3/IRS2	-1.18094614890871
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	8/1042	105/9376	0.685568046796454	RPS27A/TOMM7/UBA52/CITED2/UBB/UBC/NLRX1/BNIP3	-1.14564689422991
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	11/1042	138/9376	0.717238309827812	PTTG1/CAMK2D/SKP1/YWHAH/SPDYE16/PPP2R5D/RPS6KA3/IGF1/RPS6KA1/PPP3CA/YWHAQ	-1.18321558872182
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	11/1042	138/9376	0.717238309827812	GYS1/RPS6/PKLR/PIK3CD/EIF4E1B/FOXO1/EIF4EBP1/CBL/PPP1R3C/SOCS3/IRS2	-1.18321558872182
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	6/1042	85/9376	0.635158631590832	ENTPD3/TYMP/ADA2/ENPP1/NUDT16/HPRT1	-1.19474455083687
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/1042	37/9376	0.486382735902889	ASRGL1/GPT	-1.10683539065774
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/1042	23/9376	0.391220896269715	MSH2	-1.03357248031182
Organismal Systems	Digestive system	hsa04976	Bile secretion	6/1042	90/9376	0.599872040946897	FXYD2/SLC4A4/LDLR/NR1H4/ATP1B2/SLC5A1	-1.34864784748278
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	4/1042	66/9376	0.545338219042634	HSD11B1/CYP17A1/DHRS9/CYP7B1	-1.31062463143769
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	3/1042	54/9376	0.499893367455748	LDHA/MAT2A/PHGDH	-1.30315986060595
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	2/1042	41/9376	0.438930761668461	SYCP3/BRCA1	-1.273045643959
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4/1042	68/9376	0.529298859659027	DHRS3/CYP2S1/ADH1B/DHRS9	-1.37741329046515
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/1042	26/9376	0.34608002362321	PKLR	-1.18058761478938
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	8/1042	117/9376	0.615253375330151	ACTB/ACTG1/SMARCE1/PHF6/MORF4L1/DPF3/MORF4L2/ZNHIT1	-1.48073880186326
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	2/1042	43/9376	0.418515377404812	ALDH3A2/ADH1B	-1.35130871839601
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	7/1042	107/9376	0.588659479433871	GYS1/CREB3L3/LDHA/CAMK2D/FOXO1/PFKP/PPP3CA	-1.51310717525543
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/1042	28/9376	0.321360021935838	ATP6V0E1	-1.27160390633906
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	2/1042	44/9376	0.409003664281975	GTF2H5/GTF2F1	-1.38936550157437
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/1042	29/9376	0.310278641869085	RASSF2	-1.31531357363287
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	7/1042	110/9376	0.572605129994765	PIK3CD/HSP90AB1/SPDYE16/RPS6KA3/IGF1/RPS6KA1/GNAI3	-1.59430808805897
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/1042	30/9376	0.299936020473448	IDH2	-1.35793262023399
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/1042	31/9376	0.290260664974305	AFMID	-1.3995319548483
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	3/1042	63/9376	0.428480029247784	POLR2L/CETN2/GTF2H5	-1.60934677300137
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/1042	32/9376	0.281190019193858	LDHA	-1.44017551367126
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/1042	32/9376	0.281190019193858	ULK2	-1.44017551367126
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	3/1042	65/9376	0.415296028347852	CREB3L3/CYP17A1/LDLR	-1.67258157546214
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	4/1042	79/9376	0.455599018440681	ATP6V0E1/SNAP25/SLC1A1/SLC18A2	-1.71812113157334
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/1042	34/9376	0.264649429829513	POLR2L	-1.51882140873517
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/1042	35/9376	0.25708801754867	PFKP	-1.55692412749351
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/1042	36/9376	0.249946683727874	RNASEH2C	-1.59427302332439
NA	NA	hsa04382	Cornified envelope formation	15/1042	217/9376	0.621987139230654	S100A4/S100A6/S100A10/UGCG/CLDN5/PCSK6/KRT26/COL4A1/SLC27A1/COL4A2/PPP2R5D/DST/S100A16/SPTLC2/S100A11	-1.99207260324727
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/1042	37/9376	0.243191367951445	UGDH	-1.63090814203674
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	2/1042	57/9376	0.315722126814156	HACD4/ELOVL6	-1.83222168330335
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/1042	44/9376	0.204501832140988	PARP4	-1.87012616524286
Human Diseases	Substance dependence	hsa05034	Alcoholism	11/1042	191/9376	0.518214066786586	MAOB/GNG2/CREB3L3/GNB1/CAMK4/GRIN2B/GNB5/GNG5/GNAO1/SLC18A2/GNAI3	-2.37861398841095
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/1042	48/9376	0.187460012795905	ALDH3A2	-1.9955556458283
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	4/1042	103/9376	0.349440023852561	NXF3/PABPC1/PPP2R5D/CSTF3	-2.34740796100643
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/1042	54/9376	0.166631122485249	BRCA1	-2.17156262201615
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	4/1042	108/9376	0.333262244970498	EEF1A1/NXF3/NUP93/SUMO1	-2.46414728864855
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	2/1042	83/9376	0.21682121961936	JARID2/SKP1	-2.53404742979101
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	4/1042	183/9376	0.196679357687507	POP5/NXF3/WDR36/POP1	-3.88041872191587
Genetic Information Processing	Transcription	hsa03040	Spliceosome	4/1042	243/9376	0.148116553320222	SNRPD2/SNRPD1/LSM5/GPKOW	-4.75739637106882
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	12/1042	449/9376	0.240483223542186	NCALD/OR2T12/CNGA4/OR2Z1/OR4P4/CAMK2D/GNB1/OR6N1/OR51I2/PDE2A/OR52E5/PDE1A	-5.83177183206086