ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003735 structural constituent of ribosome 74/1822 175/18639 0.422857142857143 4.32581464638545 8.96320995015286e-30 1.10874907083391e-26 GO:0005201 extracellular matrix structural constituent 58/1822 168/18639 0.345238095238095 3.53177434530343 1.63114955238757e-18 1.00886599815171e-15 GO:0005178 integrin binding 49/1822 161/18639 0.304347826086957 3.11346823843841 1.93798490697755e-13 7.99095776643742e-11 GO:0005518 collagen binding 29/1822 72/18639 0.402777777777778 4.12040340285401 7.2851883919648e-12 1.97924407635597e-09 GO:0005539 glycosaminoglycan binding 60/1822 242/18639 0.247933884297521 2.53635547169127 8.00017815826988e-12 1.97924407635597e-09 GO:0019838 growth factor binding 37/1822 136/18639 0.272058823529412 2.78315280557887 5.43219201307604e-09 1.11993692002918e-06 GO:0043394 proteoglycan binding 17/1822 37/18639 0.459459459459459 4.70025513988192 1.48851080321066e-08 2.63041123367369e-06 GO:0048407 platelet-derived growth factor binding 9/1822 11/18639 0.818181818181818 8.36997305658118 3.66574962293366e-08 5.66816535446117e-06 GO:0008201 heparin binding 41/1822 172/18639 0.238372093023256 2.43853866183341 5.23267326355461e-08 7.19201869668561e-06 GO:0140375 immune receptor activity 38/1822 156/18639 0.243589743589744 2.49191505530693 8.68808714075378e-08 1.07471637931124e-05 GO:1901681 sulfur compound binding 55/1822 275/18639 0.2 2.04599341383096 1.99988495663727e-07 2.24896153760028e-05 GO:0001968 fibronectin binding 14/1822 30/18639 0.466666666666667 4.77398463227223 2.22333839161901e-07 2.2918913253606e-05 GO:0030246 carbohydrate binding 55/1822 280/18639 0.196428571428571 2.0094578171554 3.68904066072007e-07 3.51026407485441e-05 GO:0042605 peptide antigen binding 17/1822 45/18639 0.377777777777778 3.86465422612514 4.81620885599631e-07 4.25546453919102e-05 GO:0023023 MHC protein complex binding 15/1822 37/18639 0.405405405405405 4.14728394695464 7.82084073053415e-07 6.44958665578049e-05 GO:0050840 extracellular matrix binding 21/1822 67/18639 0.313432835820896 3.20640758883956 8.57976255477714e-07 6.63322892516207e-05 GO:0019956 chemokine binding 14/1822 33/18639 0.424242424242424 4.33998602933839 9.43587849237095e-07 6.86598923238992e-05 GO:0061134 peptidase regulator activity 46/1822 226/18639 0.20353982300885 2.08220568664212 1.16633792979915e-06 8.01533343978641e-05 GO:0023026 MHC class II protein complex binding 12/1822 27/18639 0.444444444444444 4.54665203073546 3.14617570663482e-06 0.000204832597321436 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 20/1822 68/18639 0.294117647058824 3.00881384386905 4.68506729740639e-06 0.000289771412344585 GO:0009055 electron transfer activity 28/1822 116/18639 0.241379310344828 2.46930239600288 5.05012956147575e-06 0.000297476679406929 GO:0005200 structural constituent of cytoskeleton 27/1822 112/18639 0.241071428571429 2.46615277559981 7.59096219760994e-06 0.000426819101747432 GO:0030020 extracellular matrix structural constituent conferring tensile strength 15/1822 44/18639 0.340909090909091 3.48748877357549 9.91851648638189e-06 0.000533443691028452 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 14/1822 40/18639 0.35 3.58048847420417 1.38518288187374e-05 0.000713946343699091 GO:0003779 actin binding 71/1822 443/18639 0.160270880361174 1.63956582823925 2.03923636934811e-05 0.00100901415555344 GO:0031386 protein tag activity 8/1822 15/18639 0.533333333333333 5.45598243688255 2.81408810296519e-05 0.00128926925309924 GO:0141047 molecular tag activity 8/1822 15/18639 0.533333333333333 5.45598243688255 2.81408810296519e-05 0.00128926925309924 GO:0002020 protease binding 29/1822 136/18639 0.213235294117647 2.18139003680506 4.31806202200138e-05 0.00190765811471989 GO:0015078 proton transmembrane transporter activity 36/1822 185/18639 0.194594594594595 1.99069629453823 4.47584396358148e-05 0.00190917895963803 GO:0019955 cytokine binding 30/1822 144/18639 0.208333333333333 2.13124313940724 5.09286743906235e-05 0.00209995900737338 GO:0016209 antioxidant activity 21/1822 86/18639 0.244186046511628 2.49801521456105 6.17627357223535e-05 0.00246453238995327 GO:0030414 peptidase inhibitor activity 33/1822 169/18639 0.195266272189349 1.99756753421365 8.50529744305328e-05 0.00328782904283028 GO:0061135 endopeptidase regulator activity 35/1822 184/18639 0.190217391304348 1.94591764902401 9.17426356655017e-05 0.00343895879752199 GO:0005164 tumor necrosis factor receptor binding 11/1822 31/18639 0.354838709677419 3.62998831486137 0.000100484041277141 0.0036558458547007 GO:0004896 cytokine receptor activity 22/1822 96/18639 0.229166666666667 2.34436745334797 0.00011550972100522 0.00408244356809877 GO:0032395 MHC class II receptor activity 6/1822 10/18639 0.6 6.13798024149286 0.000128424091569446 0.00441279447976124 GO:0004857 enzyme inhibitor activity 64/1822 416/18639 0.153846153846154 1.57384108756227 0.000172176116047735 0.00575626636624456 GO:0004866 endopeptidase inhibitor activity 31/1822 161/18639 0.192546583850932 1.96974521207328 0.000179172912904568 0.00583254982270921 GO:0005520 insulin-like growth factor binding 8/1822 19/18639 0.421052631578947 4.30735455543359 0.000231016158006463 0.00732579342423429 GO:0003725 double-stranded RNA binding 18/1822 75/18639 0.24 2.45519209659715 0.000255117477127234 0.00732579342423429 GO:0042608 T cell receptor binding 6/1822 11/18639 0.545454545454545 5.57998203772079 0.000259110122784699 0.00732579342423429 GO:0097493 structural molecule activity conferring elasticity 6/1822 11/18639 0.545454545454545 5.57998203772079 0.000259110122784699 0.00732579342423429 GO:1990948 ubiquitin ligase inhibitor activity 6/1822 11/18639 0.545454545454545 5.57998203772079 0.000259110122784699 0.00732579342423429 GO:0019957 C-C chemokine binding 9/1822 24/18639 0.375 3.83623765093304 0.000267310738166293 0.00732579342423429 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 7/1822 15/18639 0.466666666666667 4.77398463227223 0.000267333978515154 0.00732579342423429 GO:0043236 laminin binding 10/1822 29/18639 0.344827586206897 3.52757485143268 0.000272422390876942 0.00732579342423429 GO:0005125 cytokine activity 40/1822 234/18639 0.170940170940171 1.74871231951364 0.000330708125975534 0.00870395642195183 GO:0003823 antigen binding 32/1822 174/18639 0.183908045977011 1.88137325409743 0.000338836474149277 0.00873209830255533 GO:0008137 NADH dehydrogenase (ubiquinone) activity 12/1822 41/18639 0.292682926829268 2.99413670316725 0.000390664164038205 0.00986227695745429 GO:0022853 active monoatomic ion transmembrane transporter activity 24/1822 118/18639 0.203389830508475 2.08067126830267 0.000401465243737296 0.00993225013006069 GO:0140328 floppase activity 7/1822 16/18639 0.4375 4.47561059275521 0.000435242635382259 0.0105567674503501 GO:0043178 alcohol binding 20/1822 92/18639 0.217391304347826 2.22390588459886 0.000485348156521921 0.0115456859541849 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 8/1822 21/18639 0.380952380952381 3.89713031205896 0.00052036602323753 0.0121451466178269 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 9/1822 27/18639 0.333333333333333 3.40998902305159 0.000731303239317911 0.0165249552188628 GO:0005126 cytokine receptor binding 44/1822 275/18639 0.16 1.63679473106476 0.000742004966484315 0.0165249552188628 GO:0030021 extracellular matrix structural constituent conferring compression resistance 8/1822 22/18639 0.363636363636364 3.71998802514719 0.000748098215243585 0.0165249552188628 GO:0003954 NADH dehydrogenase activity 12/1822 44/18639 0.272727272727273 2.78999101886039 0.000791459414626102 0.0171760578226752 GO:0031994 insulin-like growth factor I binding 6/1822 13/18639 0.461538461538462 4.72152326268682 0.000809891361313768 0.0172730278266402 GO:0045296 cadherin binding 51/1822 334/18639 0.152694610778443 1.56206083990088 0.000890659393980352 0.0186736554297236 GO:0001540 amyloid-beta binding 18/1822 83/18639 0.216867469879518 2.21854707523838 0.000937982660888077 0.0193380758586425 GO:0016493 C-C chemokine receptor activity 8/1822 23/18639 0.347826086956522 3.55824941535818 0.00104956049341268 0.0212837103336308 GO:0051015 actin filament binding 35/1822 209/18639 0.167464114832536 1.713152380002 0.00109821802929448 0.0219112210038269 GO:0042277 peptide binding 40/1822 249/18639 0.160642570281124 1.64336820388029 0.00116409789792704 0.0228569698370754 GO:0004629 phospholipase C activity 9/1822 29/18639 0.310344827586207 3.17481736628941 0.00130580972756641 0.0252388536406196 GO:0015399 primary active transmembrane transporter activity 29/1822 166/18639 0.174698795180723 1.78716292171981 0.00145325804307831 0.0275194556121038 GO:0005522 profilin binding 5/1822 10/18639 0.5 5.11498353457739 0.0014682975508479 0.0275194556121038 GO:0001965 G-protein alpha-subunit binding 9/1822 30/18639 0.3 3.06899012074643 0.00170554428873259 0.0314889296292868 GO:0033218 amide binding 39/1822 247/18639 0.157894736842105 1.6152579582876 0.00183927194538413 0.0334585205358848 GO:0001618 virus receptor activity 17/1822 81/18639 0.209876543209877 2.14703012562508 0.00187422461247617 0.0336002296468553 GO:0004129 cytochrome-c oxidase activity 6/1822 15/18639 0.4 4.09198682766191 0.00198932231854432 0.0346590381413989 GO:0055105 ubiquitin-protein transferase inhibitor activity 6/1822 15/18639 0.4 4.09198682766191 0.00198932231854432 0.0346590381413989 GO:0001664 G protein-coupled receptor binding 45/1822 297/18639 0.151515151515152 1.549995010478 0.00201927288877329 0.0346922300473967 GO:0016004 phospholipase activator activity 7/1822 20/18639 0.35 3.58048847420417 0.00207772798862549 0.0347317502963478 GO:0016505 peptidase activator activity involved in apoptotic process 7/1822 20/18639 0.35 3.58048847420417 0.00207772798862549 0.0347317502963478 GO:0140272 exogenous protein binding 17/1822 82/18639 0.207317073170732 2.12084683141014 0.00215333698044761 0.0355157045975158 GO:0098631 cell adhesion mediator activity 16/1822 76/18639 0.210526315789474 2.15367727771679 0.00243348307238615 0.0391529622141289 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 5/1822 11/18639 0.454545454545455 4.64998503143399 0.00247595374090057 0.0391529622141289 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 5/1822 11/18639 0.454545454545455 4.64998503143399 0.00247595374090057 0.0391529622141289 GO:0001637 G protein-coupled chemoattractant receptor activity 8/1822 26/18639 0.307692307692308 3.14768217512455 0.00256377521369801 0.0391529622141289 GO:0004950 chemokine receptor activity 8/1822 26/18639 0.307692307692308 3.14768217512455 0.00256377521369801 0.0391529622141289 GO:0043548 phosphatidylinositol 3-kinase binding 8/1822 26/18639 0.307692307692308 3.14768217512455 0.00256377521369801 0.0391529622141289 GO:0004601 peroxidase activity 13/1822 57/18639 0.228070175438596 2.33315038419319 0.00288542141398853 0.0435276376719977 GO:0016675 oxidoreductase activity, acting on a heme group of donors 6/1822 16/18639 0.375 3.83623765093304 0.00292177012844156 0.0435449355287014 GO:0140303 intramembrane lipid transporter activity 11/1822 45/18639 0.244444444444444 2.5006586169045 0.00335267296376391 0.0493721006687614 GO:0031683 G-protein beta/gamma-subunit complex binding 7/1822 22/18639 0.318181818181818 3.25498952200379 0.00384028732415489 0.0558874755291717 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 13/1822 59/18639 0.220338983050847 2.25406054066122 0.0039699925107064 0.0571032643691141 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 6/1822 17/18639 0.352941176470588 3.61057661264286 0.00414580104551421 0.0589466194632309 GO:0015036 disulfide oxidoreductase activity 10/1822 40/18639 0.25 2.55749176728869 0.00426137604214648 0.059901388228809 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 7/1822 23/18639 0.304347826086957 3.11346823843841 0.00506123031260461 0.0671306753399459 GO:0004602 glutathione peroxidase activity 7/1822 23/18639 0.304347826086957 3.11346823843841 0.00506123031260461 0.0671306753399459 GO:0043274 phospholipase binding 7/1822 23/18639 0.304347826086957 3.11346823843841 0.00506123031260461 0.0671306753399459 GO:0099186 structural constituent of postsynapse 7/1822 23/18639 0.304347826086957 3.11346823843841 0.00506123031260461 0.0671306753399459 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 7/1822 23/18639 0.304347826086957 3.11346823843841 0.00506123031260461 0.0671306753399459 GO:0042287 MHC protein binding 10/1822 41/18639 0.24390243902439 2.49511391930604 0.00515176689289919 0.0671306753399459 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 12/1822 54/18639 0.222222222222222 2.27332601536773 0.0051555490358083 0.0671306753399459 GO:0008307 structural constituent of muscle 10/1822 42/18639 0.238095238095238 2.43570644503685 0.00618143092540627 0.0796503130700787 GO:0060229 lipase activator activity 7/1822 24/18639 0.291666666666667 2.98374039517014 0.0065520429356035 0.0835554341375416 GO:0043395 heparan sulfate proteoglycan binding 6/1822 19/18639 0.315789473684211 3.23051591657519 0.00766626480126065 0.0967670363179533 GO:0032813 tumor necrosis factor receptor superfamily binding 11/1822 50/18639 0.22 2.25059275521405 0.00784884508234322 0.097400261051362 GO:0005319 lipid transporter activity 28/1822 178/18639 0.157303370786517 1.60920830301311 0.00787390954335991 0.097400261051362 GO:0016504 peptidase activator activity 12/1822 57/18639 0.210526315789474 2.15367727771679 0.00809306150173209 0.0991199710657683 GO:0005161 platelet-derived growth factor receptor binding 5/1822 14/18639 0.357142857142857 3.65355966755528 0.00836096348953169 0.101397174868144 GO:0005096 GTPase activator activity 39/1822 271/18639 0.143911439114391 1.47220928301489 0.00911554266335971 0.109475012374524 GO:0019843 rRNA binding 13/1822 65/18639 0.2 2.04599341383096 0.00930465121362456 0.109789625033901 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 12/1822 58/18639 0.206896551724138 2.11654491085961 0.00931924868921555 0.109789625033901 GO:0030695 GTPase regulator activity 64/1822 489/18639 0.130879345603272 1.338891395554 0.00964602856613948 0.112567333361458 GO:0042288 MHC class I protein binding 6/1822 20/18639 0.3 3.06899012074643 0.0100613520066757 0.115311247589765 GO:0060589 nucleoside-triphosphatase regulator activity 64/1822 490/18639 0.130612244897959 1.3361589641345 0.0100675947774411 0.115311247589765 GO:0019902 phosphatase binding 29/1822 190/18639 0.152631578947368 1.56141602634468 0.0104513803469675 0.117810425971849 GO:0004435 phosphatidylinositol phospholipase C activity 7/1822 26/18639 0.269230769230769 2.75422190323398 0.0104762707008111 0.117810425971849 GO:0005402 carbohydrate:monoatomic cation symporter activity 5/1822 15/18639 0.333333333333333 3.40998902305159 0.0115467840750254 0.127972261992457 GO:0031996 thioesterase binding 4/1822 10/18639 0.4 4.09198682766191 0.0117937250340663 0.127972261992457 GO:0035374 chondroitin sulfate binding 4/1822 10/18639 0.4 4.09198682766191 0.0117937250340663 0.127972261992457 GO:0043208 glycosphingolipid binding 4/1822 10/18639 0.4 4.09198682766191 0.0117937250340663 0.127972261992457 GO:0044325 transmembrane transporter binding 22/1822 136/18639 0.161764705882353 1.65484761412798 0.0125625071520171 0.135128881278654 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 6/1822 21/18639 0.285714285714286 2.92284773404422 0.0129433292208183 0.13718642548469 GO:0004364 glutathione transferase activity 7/1822 27/18639 0.259259259259259 2.65221368459568 0.0129755956198131 0.13718642548469 GO:0140793 histone H2AXY142 phosphatase activity 16/1822 90/18639 0.177777777777778 1.81866081229418 0.0131808401799254 0.138175417818371 GO:0015026 coreceptor activity 12/1822 61/18639 0.19672131147541 2.01245253819438 0.0138748482483291 0.143428194529476 GO:0001784 phosphotyrosine residue binding 10/1822 47/18639 0.212765957446809 2.17658873811804 0.0139138103019702 0.143428194529476 GO:0015485 cholesterol binding 11/1822 54/18639 0.203703703703704 2.08388218075375 0.0140335171064708 0.143466617030614 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 21/1822 130/18639 0.161538461538462 1.65253314194039 0.0147230068144812 0.148457107275098 GO:0015035 protein-disulfide reductase activity 8/1822 34/18639 0.235294117647059 2.40705107509524 0.0147617010467559 0.148457107275098 GO:0019841 retinol binding 5/1822 16/18639 0.3125 3.19686470911087 0.0154672449598362 0.154298242059011 GO:0017124 SH3 domain binding 19/1822 115/18639 0.165217391304348 1.69016847229514 0.0157395275629771 0.155758364763221 GO:0046875 ephrin receptor binding 7/1822 28/18639 0.25 2.55749176728869 0.0158756481664058 0.155858545887651 GO:0033691 sialic acid binding 6/1822 22/18639 0.272727272727273 2.78999101886039 0.016356969932067 0.159319463039109 GO:0043177 organic acid binding 28/1822 189/18639 0.148148148148148 1.51555067691182 0.0170643148675102 0.164148612877702 GO:0004954 prostanoid receptor activity 4/1822 11/18639 0.363636363636364 3.71998802514719 0.0171181657730182 0.164148612877702 GO:0051219 phosphoprotein binding 16/1822 93/18639 0.172043010752688 1.75999433447824 0.0177390325121897 0.168793717058297 GO:0001222 transcription corepressor binding 10/1822 49/18639 0.204081632653061 2.08774838146016 0.0184832987454043 0.173210913242917 GO:0016763 pentosyltransferase activity 10/1822 49/18639 0.204081632653061 2.08774838146016 0.0184832987454043 0.173210913242917 GO:0051861 glycolipid binding 7/1822 29/18639 0.241379310344828 2.46930239600288 0.0192066691951034 0.17863646461912 GO:0046332 SMAD binding 14/1822 79/18639 0.177215189873418 1.81290555655907 0.0201031046138305 0.182356223425868 GO:0030169 low-density lipoprotein particle binding 5/1822 17/18639 0.294117647058824 3.00881384386905 0.0201845132574704 0.182356223425868 GO:0070492 oligosaccharide binding 5/1822 17/18639 0.294117647058824 3.00881384386905 0.0201845132574704 0.182356223425868 GO:0042171 lysophosphatidic acid acyltransferase activity 6/1822 23/18639 0.260869565217391 2.66868706151864 0.0203437015624655 0.182356223425868 GO:0071617 lysophospholipid acyltransferase activity 6/1822 23/18639 0.260869565217391 2.66868706151864 0.0203437015624655 0.182356223425868 GO:0004869 cysteine-type endopeptidase inhibitor activity 8/1822 36/18639 0.222222222222222 2.27332601536773 0.0206728574353983 0.183973558615739 GO:0008081 phosphoric diester hydrolase activity 15/1822 87/18639 0.172413793103448 1.76378742571634 0.0208594629553319 0.184308254826754 GO:0048020 CCR chemokine receptor binding 10/1822 50/18639 0.2 2.04599341383096 0.0211419121611696 0.184788011686074 GO:0008375 acetylglucosaminyltransferase activity 9/1822 43/18639 0.209302325581395 2.14115589819519 0.0212125284231386 0.184788011686074 GO:0003924 GTPase activity 44/1822 331/18639 0.132930513595166 1.35987477656438 0.022092354442247 0.191106590524892 GO:0038024 cargo receptor activity 12/1822 65/18639 0.184615384615385 1.88860930507473 0.0223658717433577 0.192129051017594 GO:0016651 oxidoreductase activity, acting on NAD(P)H 15/1822 88/18639 0.170454545454545 1.74374438678775 0.0229489783891702 0.194844745144532 GO:0098918 structural constituent of synapse 7/1822 30/18639 0.233333333333333 2.38699231613611 0.0229970354010523 0.194844745144532 GO:0035259 nuclear glucocorticoid receptor binding 4/1822 12/18639 0.333333333333333 3.40998902305159 0.0237247683138143 0.198294178406677 GO:0070008 serine-type exopeptidase activity 4/1822 12/18639 0.333333333333333 3.40998902305159 0.0237247683138143 0.198294178406677 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 15/1822 89/18639 0.168539325842697 1.72415175322833 0.0251917674318887 0.205512372069889 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 15/1822 89/18639 0.168539325842697 1.72415175322833 0.0251917674318887 0.205512372069889 GO:0031406 carboxylic acid binding 27/1822 187/18639 0.144385026737968 1.47705406880844 0.0255320949529079 0.205512372069889 GO:0008083 growth factor activity 24/1822 162/18639 0.148148148148148 1.51555067691182 0.0257317011861891 0.205512372069889 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 5/1822 18/18639 0.277777777777778 2.84165751920966 0.0257513481575043 0.205512372069889 GO:0031690 adrenergic receptor binding 5/1822 18/18639 0.277777777777778 2.84165751920966 0.0257513481575043 0.205512372069889 GO:0098641 cadherin binding involved in cell-cell adhesion 5/1822 18/18639 0.277777777777778 2.84165751920966 0.0257513481575043 0.205512372069889 GO:0000287 magnesium ion binding 32/1822 230/18639 0.139130434782609 1.42329976614327 0.0261863633831114 0.206669024428943 GO:0045309 protein phosphorylated amino acid binding 11/1822 59/18639 0.186440677966102 1.90728199594411 0.0262304258976104 0.206669024428943 GO:0016411 acylglycerol O-acyltransferase activity 7/1822 31/18639 0.225806451612903 2.30999256400269 0.0272728837850806 0.210596715161644 GO:0070325 lipoprotein particle receptor binding 7/1822 31/18639 0.225806451612903 2.30999256400269 0.0272728837850806 0.210596715161644 GO:0004725 protein tyrosine phosphatase activity 16/1822 98/18639 0.163265306122449 1.67019870516813 0.0279042831358481 0.210596715161644 GO:0004715 non-membrane spanning protein tyrosine kinase activity 9/1822 45/18639 0.2 2.04599341383096 0.0279713656912127 0.210596715161644 GO:0008009 chemokine activity 9/1822 45/18639 0.2 2.04599341383096 0.0279713656912127 0.210596715161644 GO:0005109 frizzled binding 8/1822 38/18639 0.210526315789474 2.15367727771679 0.0280909118849405 0.210596715161644 GO:0005501 retinoid binding 8/1822 38/18639 0.210526315789474 2.15367727771679 0.0280909118849405 0.210596715161644 GO:0019840 isoprenoid binding 8/1822 38/18639 0.210526315789474 2.15367727771679 0.0280909118849405 0.210596715161644 GO:0016757 glycosyltransferase activity 36/1822 267/18639 0.134831460674157 1.37932140258267 0.0295814731950385 0.220435435796763 GO:0019211 phosphatase activator activity 6/1822 25/18639 0.24 2.45519209659715 0.0301814277312177 0.223559437745607 GO:0005516 calmodulin binding 29/1822 207/18639 0.140096618357488 1.43318379229705 0.0304587003914926 0.223843534490381 GO:0032934 sterol binding 12/1822 68/18639 0.176470588235294 1.80528830632143 0.0308864666497714 0.223843534490381 GO:0140333 glycerophospholipid flippase activity 4/1822 13/18639 0.307692307692308 3.14768217512455 0.0316738302209555 0.223843534490381 GO:0140410 monoatomic cation:bicarbonate symporter activity 4/1822 13/18639 0.307692307692308 3.14768217512455 0.0316738302209555 0.223843534490381 GO:0004180 carboxypeptidase activity 9/1822 46/18639 0.195652173913043 2.00151529613898 0.0318624853405506 0.223843534490381 GO:0015106 bicarbonate transmembrane transporter activity 7/1822 32/18639 0.21875 2.23780529637761 0.0320577805591618 0.223843534490381 GO:0071813 lipoprotein particle binding 7/1822 32/18639 0.21875 2.23780529637761 0.0320577805591618 0.223843534490381 GO:0071814 protein-lipid complex binding 7/1822 32/18639 0.21875 2.23780529637761 0.0320577805591618 0.223843534490381 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 5/1822 19/18639 0.263157894736842 2.69209659714599 0.03221030649902 0.223843534490381 GO:0016918 retinal binding 5/1822 19/18639 0.263157894736842 2.69209659714599 0.03221030649902 0.223843534490381 GO:0034987 immunoglobulin receptor binding 5/1822 19/18639 0.263157894736842 2.69209659714599 0.03221030649902 0.223843534490381 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 8/1822 39/18639 0.205128205128205 2.09845478341636 0.0324136212666169 0.223998041937458 GO:0044389 ubiquitin-like protein ligase binding 42/1822 322/18639 0.130434782608696 1.33434353075932 0.0326873445431929 0.224501914721623 GO:0022804 active transmembrane transporter activity 57/1822 457/18639 0.12472647702407 1.27594775260793 0.0328495121783459 0.224501914721623 GO:0004620 phospholipase activity 17/1822 109/18639 0.155963302752294 1.59549945115258 0.0355643070983374 0.241335188527028 GO:0005160 transforming growth factor beta receptor binding 6/1822 26/18639 0.230769230769231 2.36076163134341 0.0360929748403397 0.241335188527028 GO:0019865 immunoglobulin binding 6/1822 26/18639 0.230769230769231 2.36076163134341 0.0360929748403397 0.241335188527028 GO:0050750 low-density lipoprotein particle receptor binding 6/1822 26/18639 0.230769230769231 2.36076163134341 0.0360929748403397 0.241335188527028 GO:0071889 14-3-3 protein binding 7/1822 33/18639 0.212121212121212 2.1699930146692 0.0373724379299857 0.248546804942969 GO:0098632 cell-cell adhesion mediator activity 10/1822 55/18639 0.181818181818182 1.8599940125736 0.0387004104939719 0.254640466920443 GO:0140313 molecular sequestering activity 10/1822 55/18639 0.181818181818182 1.8599940125736 0.0387004104939719 0.254640466920443 GO:0001614 purinergic nucleotide receptor activity 5/1822 20/18639 0.25 2.55749176728869 0.0395932913298013 0.257773165131391 GO:0016502 nucleotide receptor activity 5/1822 20/18639 0.25 2.55749176728869 0.0395932913298013 0.257773165131391 GO:0005507 copper ion binding 11/1822 63/18639 0.174603174603175 1.78618472636036 0.040435888377916 0.261880596458022 GO:0032036 myosin heavy chain binding 4/1822 14/18639 0.285714285714286 2.92284773404422 0.0409989769135251 0.262775826124511 GO:0044548 S100 protein binding 4/1822 14/18639 0.285714285714286 2.92284773404422 0.0409989769135251 0.262775826124511 GO:0042169 SH2 domain binding 8/1822 41/18639 0.195121951219512 1.99609113544483 0.0423690730425403 0.270157439967125 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 6/1822 27/18639 0.222222222222222 2.27332601536773 0.0426979403319186 0.270858216361966 GO:0008376 acetylgalactosaminyltransferase activity 7/1822 34/18639 0.205882352941176 2.10616969070834 0.0432344808256379 0.272862514190378 GO:0008194 UDP-glycosyltransferase activity 21/1822 145/18639 0.144827586206897 1.48158143760173 0.0434939990046317 0.273106988673753 GO:0031625 ubiquitin protein ligase binding 39/1822 302/18639 0.129139072847682 1.32108846257297 0.0437398152169222 0.273263391026933 GO:0042379 chemokine receptor binding 12/1822 72/18639 0.166666666666667 1.7049945115258 0.0455700580806101 0.283101313770309 GO:0035591 signaling adaptor activity 19/1822 129/18639 0.147286821705426 1.50673933576698 0.0457722415150056 0.283101313770309 GO:0009931 calcium-dependent protein serine/threonine kinase activity 5/1822 21/18639 0.238095238095238 2.43570644503685 0.0479214044888587 0.292669808372278 GO:0061891 calcium ion sensor activity 5/1822 21/18639 0.238095238095238 2.43570644503685 0.0479214044888587 0.292669808372278 GO:0016859 cis-trans isomerase activity 8/1822 42/18639 0.19047619047619 1.94856515602948 0.0480290793044239 0.292669808372278 GO:0016298 lipase activity 19/1822 130/18639 0.146153846153846 1.49514903318416 0.0488958500748687 0.296491012463787 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 4/1822 15/18639 0.266666666666667 2.72799121844127 0.051708865218434 0.307518587861552 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 4/1822 15/18639 0.266666666666667 2.72799121844127 0.051708865218434 0.307518587861552 GO:0004953 icosanoid receptor activity 4/1822 15/18639 0.266666666666667 2.72799121844127 0.051708865218434 0.307518587861552 GO:0005523 tropomyosin binding 4/1822 15/18639 0.266666666666667 2.72799121844127 0.051708865218434 0.307518587861552 GO:0048156 tau protein binding 8/1822 43/18639 0.186046511627907 1.90324968728461 0.0541585766487177 0.320546216815616 GO:0048029 monosaccharide binding 12/1822 74/18639 0.162162162162162 1.65891357878186 0.0544698344092053 0.320853262686604 GO:0055106 ubiquitin-protein transferase regulator activity 7/1822 36/18639 0.194444444444444 1.98916026344676 0.056654741924554 0.327485587666698 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 7/1822 36/18639 0.194444444444444 1.98916026344676 0.056654741924554 0.327485587666698 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 7/1822 36/18639 0.194444444444444 1.98916026344676 0.056654741924554 0.327485587666698 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 7/1822 36/18639 0.194444444444444 1.98916026344676 0.056654741924554 0.327485587666698 GO:0140784 metal ion sensor activity 5/1822 22/18639 0.227272727272727 2.32499251571699 0.0572050617114444 0.329128657381659 GO:0008236 serine-type peptidase activity 26/1822 194/18639 0.134020618556701 1.3710265144228 0.0608062868042277 0.348228596189026 GO:0005085 guanyl-nucleotide exchange factor activity 30/1822 230/18639 0.130434782608696 1.33434353075932 0.0627863769483843 0.350737001407372 GO:0030159 signaling receptor complex adaptor activity 9/1822 52/18639 0.173076923076923 1.77057122350756 0.063156851066698 0.350737001407372 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 4/1822 16/18639 0.25 2.55749176728869 0.0637894053046334 0.350737001407372 GO:0005521 lamin binding 4/1822 16/18639 0.25 2.55749176728869 0.0637894053046334 0.350737001407372 GO:0015562 efflux transmembrane transporter activity 4/1822 16/18639 0.25 2.55749176728869 0.0637894053046334 0.350737001407372 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 4/1822 16/18639 0.25 2.55749176728869 0.0637894053046334 0.350737001407372 GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 4/1822 16/18639 0.25 2.55749176728869 0.0637894053046334 0.350737001407372 GO:0140327 flippase activity 4/1822 16/18639 0.25 2.55749176728869 0.0637894053046334 0.350737001407372 GO:0051117 ATPase binding 13/1822 84/18639 0.154761904761905 1.58320918927395 0.0637961401104758 0.350737001407372 GO:0004955 prostaglandin receptor activity 3/1822 10/18639 0.3 3.06899012074643 0.0663231403864216 0.352110406257526 GO:0005031 tumor necrosis factor receptor activity 3/1822 10/18639 0.3 3.06899012074643 0.0663231403864216 0.352110406257526 GO:0005528 FK506 binding 3/1822 10/18639 0.3 3.06899012074643 0.0663231403864216 0.352110406257526 GO:0008239 dipeptidyl-peptidase activity 3/1822 10/18639 0.3 3.06899012074643 0.0663231403864216 0.352110406257526 GO:0015203 polyamine transmembrane transporter activity 3/1822 10/18639 0.3 3.06899012074643 0.0663231403864216 0.352110406257526 GO:0030957 Tat protein binding 3/1822 10/18639 0.3 3.06899012074643 0.0663231403864216 0.352110406257526 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 3/1822 10/18639 0.3 3.06899012074643 0.0663231403864216 0.352110406257526 GO:0140999 histone H3K4 trimethyltransferase activity 3/1822 10/18639 0.3 3.06899012074643 0.0663231403864216 0.352110406257526 GO:0017134 fibroblast growth factor binding 5/1822 23/18639 0.217391304347826 2.22390588459886 0.0674443284194941 0.356532625021001 GO:0019903 protein phosphatase binding 20/1822 144/18639 0.138888888888889 1.42082875960483 0.0684042492023129 0.360068324524515 GO:0005544 calcium-dependent phospholipid binding 9/1822 53/18639 0.169811320754717 1.73716421929043 0.0697804349618375 0.365755923931326 GO:0017171 serine hydrolase activity 26/1822 198/18639 0.131313131313131 1.34332900908093 0.0739052262193076 0.385741623769129 GO:0019199 transmembrane receptor protein kinase activity 12/1822 78/18639 0.153846153846154 1.57384108756227 0.0756067092939612 0.391410602948667 GO:0097110 scaffold protein binding 11/1822 70/18639 0.157142857142857 1.60756625372432 0.0766141805904926 0.391410602948667 GO:0004029 aldehyde dehydrogenase (NAD+) activity 4/1822 17/18639 0.235294117647059 2.40705107509524 0.0772062951652989 0.391410602948667 GO:0017110 nucleoside diphosphate phosphatase activity 4/1822 17/18639 0.235294117647059 2.40705107509524 0.0772062951652989 0.391410602948667 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 4/1822 17/18639 0.235294117647059 2.40705107509524 0.0772062951652989 0.391410602948667 GO:0045125 bioactive lipid receptor activity 4/1822 17/18639 0.235294117647059 2.40705107509524 0.0772062951652989 0.391410602948667 GO:0046965 nuclear retinoid X receptor binding 4/1822 17/18639 0.235294117647059 2.40705107509524 0.0772062951652989 0.391410602948667 GO:0005540 hyaluronic acid binding 5/1822 24/18639 0.208333333333333 2.13124313940724 0.0786294356075839 0.392196015510408 GO:0015149 hexose transmembrane transporter activity 5/1822 24/18639 0.208333333333333 2.13124313940724 0.0786294356075839 0.392196015510408 GO:0050431 transforming growth factor beta binding 5/1822 24/18639 0.208333333333333 2.13124313940724 0.0786294356075839 0.392196015510408 GO:0055056 D-glucose transmembrane transporter activity 5/1822 24/18639 0.208333333333333 2.13124313940724 0.0786294356075839 0.392196015510408 GO:1901682 sulfur compound transmembrane transporter activity 10/1822 63/18639 0.158730158730159 1.62380429669123 0.084014033822654 0.40963547756561 GO:0008374 O-acyltransferase activity 9/1822 55/18639 0.163636363636364 1.67399461131624 0.0842788663800107 0.40963547756561 GO:0005114 type II transforming growth factor beta receptor binding 3/1822 11/18639 0.272727272727273 2.78999101886039 0.0847750058664481 0.40963547756561 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 3/1822 11/18639 0.272727272727273 2.78999101886039 0.0847750058664481 0.40963547756561 GO:0032794 GTPase activating protein binding 3/1822 11/18639 0.272727272727273 2.78999101886039 0.0847750058664481 0.40963547756561 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 3/1822 11/18639 0.272727272727273 2.78999101886039 0.0847750058664481 0.40963547756561 GO:0050998 nitric-oxide synthase binding 3/1822 11/18639 0.272727272727273 2.78999101886039 0.0847750058664481 0.40963547756561 GO:0140031 phosphorylation-dependent protein binding 3/1822 11/18639 0.272727272727273 2.78999101886039 0.0847750058664481 0.40963547756561 GO:0120015 sterol transfer activity 6/1822 32/18639 0.1875 1.91811882546652 0.0865125325960118 0.416404680238391 GO:0004713 protein tyrosine kinase activity 19/1822 140/18639 0.135714285714286 1.38835267367101 0.0887280278046334 0.425413063543921 GO:0015271 outward rectifier potassium channel activity 5/1822 25/18639 0.2 2.04599341383096 0.0907414375766754 0.432280743472899 GO:0008013 beta-catenin binding 15/1822 106/18639 0.141509433962264 1.44763684940869 0.0918816819604545 0.432280743472899 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 4/1822 18/18639 0.222222222222222 2.27332601536773 0.0919077085960973 0.432280743472899 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 4/1822 18/18639 0.222222222222222 2.27332601536773 0.0919077085960973 0.432280743472899 GO:0016854 racemase and epimerase activity 4/1822 18/18639 0.222222222222222 2.27332601536773 0.0919077085960973 0.432280743472899 GO:0035401 histone H3Y41 kinase activity 16/1822 115/18639 0.139130434782609 1.42329976614327 0.0941554259510314 0.439510422269531 GO:0140801 histone H2AXY142 kinase activity 16/1822 115/18639 0.139130434782609 1.42329976614327 0.0941554259510314 0.439510422269531 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 6/1822 33/18639 0.181818181818182 1.8599940125736 0.0974325536329066 0.451401006906013 GO:0030296 protein tyrosine kinase activator activity 6/1822 33/18639 0.181818181818182 1.8599940125736 0.0974325536329066 0.451401006906013 GO:0015294 solute:monoatomic cation symporter activity 16/1822 116/18639 0.137931034482759 1.41102994057307 0.0998204963653816 0.460738634343198 GO:0051087 protein-folding chaperone binding 18/1822 134/18639 0.134328358208955 1.37417468093124 0.102856620208225 0.471847175412033 GO:0005496 steroid binding 15/1822 108/18639 0.138888888888889 1.42082875960483 0.10374653690705 0.471847175412033 GO:0015145 monosaccharide transmembrane transporter activity 5/1822 26/18639 0.192307692307692 1.96730135945284 0.103752976323422 0.471847175412033 GO:0030247 polysaccharide binding 5/1822 26/18639 0.192307692307692 1.96730135945284 0.103752976323422 0.471847175412033 GO:0005527 macrolide binding 3/1822 12/18639 0.25 2.55749176728869 0.105125085050659 0.472426814253623 GO:0045295 gamma-catenin binding 3/1822 12/18639 0.25 2.55749176728869 0.105125085050659 0.472426814253623 GO:0097371 MDM2/MDM4 family protein binding 3/1822 12/18639 0.25 2.55749176728869 0.105125085050659 0.472426814253623 GO:1990782 protein tyrosine kinase binding 16/1822 117/18639 0.136752136752137 1.39896985561091 0.105692535529715 0.472426814253623 GO:0016758 hexosyltransferase activity 25/1822 197/18639 0.126903553299492 1.29821917121253 0.10578999801799 0.472426814253623 GO:0070003 threonine-type peptidase activity 4/1822 19/18639 0.210526315789474 2.15367727771679 0.107827015821985 0.479791433711493 GO:0030165 PDZ domain binding 12/1822 83/18639 0.144578313253012 1.47903138349226 0.108522039615151 0.48115327241556 GO:0090482 vitamin transmembrane transporter activity 6/1822 34/18639 0.176470588235294 1.80528830632143 0.109046426377321 0.481751533674094 GO:0140789 histone phosphatase activity 18/1822 136/18639 0.132352941176471 1.35396622974107 0.11413109378288 0.502420508930329 GO:0016500 protein-hormone receptor activity 10/1822 67/18639 0.149253731343284 1.52686075659026 0.115326656334742 0.505883240730764 GO:0005044 scavenger receptor activity 5/1822 27/18639 0.185185185185185 1.89443834613977 0.117629120866945 0.512349375043702 GO:0008395 steroid hydroxylase activity 5/1822 27/18639 0.185185185185185 1.89443834613977 0.117629120866945 0.512349375043702 GO:0005154 epidermal growth factor receptor binding 6/1822 35/18639 0.171428571428571 1.75370864042653 0.121333632306768 0.525142832134103 GO:0008238 exopeptidase activity 14/1822 102/18639 0.137254901960784 1.40411312713889 0.121415400153883 0.525142832134103 GO:0005548 phospholipid transporter activity 10/1822 68/18639 0.147058823529412 1.50440692193453 0.124053063270622 0.532701027141389 GO:0001972 retinoic acid binding 4/1822 20/18639 0.2 2.04599341383096 0.124885446945031 0.532701027141389 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 4/1822 20/18639 0.2 2.04599341383096 0.124885446945031 0.532701027141389 GO:0031418 L-ascorbic acid binding 4/1822 20/18639 0.2 2.04599341383096 0.124885446945031 0.532701027141389 GO:0042562 hormone binding 13/1822 94/18639 0.138297872340426 1.41478267977672 0.126500365717868 0.535025479166559 GO:0005035 death receptor activity 3/1822 13/18639 0.230769230769231 2.36076163134341 0.12716046149957 0.535025479166559 GO:0061459 L-arginine transmembrane transporter activity 3/1822 13/18639 0.230769230769231 2.36076163134341 0.12716046149957 0.535025479166559 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 3/1822 13/18639 0.230769230769231 2.36076163134341 0.12716046149957 0.535025479166559 GO:0004714 transmembrane receptor protein tyrosine kinase activity 9/1822 60/18639 0.15 1.53449506037322 0.127779363244068 0.53580702485733 GO:0015108 chloride transmembrane transporter activity 16/1822 121/18639 0.132231404958678 1.35272291823534 0.131240604326845 0.547458359646907 GO:0045499 chemorepellent activity 5/1822 28/18639 0.178571428571429 1.82677983377764 0.132328253463561 0.547458359646907 GO:0051119 sugar transmembrane transporter activity 5/1822 28/18639 0.178571428571429 1.82677983377764 0.132328253463561 0.547458359646907 GO:0051393 alpha-actinin binding 5/1822 28/18639 0.178571428571429 1.82677983377764 0.132328253463561 0.547458359646907 GO:0001223 transcription coactivator binding 7/1822 44/18639 0.159090909090909 1.6274947610019 0.133410978055002 0.549971061735204 GO:0004867 serine-type endopeptidase inhibitor activity 13/1822 95/18639 0.136842105263158 1.39989023051592 0.134210230815202 0.549971061735204 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 6/1822 36/18639 0.166666666666667 1.7049945115258 0.134269410383211 0.549971061735204 GO:0004252 serine-type endopeptidase activity 22/1822 176/18639 0.125 1.27874588364435 0.137598114473147 0.560252603956896 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 9/1822 61/18639 0.147540983606557 1.50933940364579 0.137685361037103 0.560252603956896 GO:0072542 protein phosphatase activator activity 4/1822 21/18639 0.19047619047619 1.94856515602948 0.142994633405306 0.579948726302832 GO:0005543 phospholipid binding 56/1822 497/18639 0.112676056338028 1.15267234582026 0.145171682900196 0.586854156037722 GO:0003785 actin monomer binding 5/1822 29/18639 0.172413793103448 1.76378742571634 0.147802978355587 0.595544899758505 GO:0004065 arylsulfatase activity 3/1822 14/18639 0.214285714285714 2.19213580053317 0.150659048204855 0.601178202030342 GO:0008191 metalloendopeptidase inhibitor activity 3/1822 14/18639 0.214285714285714 2.19213580053317 0.150659048204855 0.601178202030342 GO:0008494 translation activator activity 3/1822 14/18639 0.214285714285714 2.19213580053317 0.150659048204855 0.601178202030342 GO:0051287 NAD binding 8/1822 54/18639 0.148148148148148 1.51555067691182 0.153233126708595 0.60948352970589 GO:0048306 calcium-dependent protein binding 11/1822 80/18639 0.1375 1.40662047200878 0.155362328357716 0.615971795443893 GO:0008093 cytoskeletal anchor activity 4/1822 22/18639 0.181818181818182 1.8599940125736 0.162058982670609 0.638429813896634 GO:0015377 chloride:monoatomic cation symporter activity 4/1822 22/18639 0.181818181818182 1.8599940125736 0.162058982670609 0.638429813896634 GO:0005506 iron ion binding 19/1822 154/18639 0.123376623376623 1.26213879424637 0.172417600345015 0.676350810050231 GO:0004521 RNA endonuclease activity 10/1822 73/18639 0.136986301369863 1.40136535193901 0.172778379931991 0.676350810050231 GO:0004559 alpha-mannosidase activity 3/1822 15/18639 0.2 2.04599341383096 0.175396593951461 0.678017458493615 GO:0015556 C4-dicarboxylate transmembrane transporter activity 3/1822 15/18639 0.2 2.04599341383096 0.175396593951461 0.678017458493615 GO:0031005 filamin binding 3/1822 15/18639 0.2 2.04599341383096 0.175396593951461 0.678017458493615 GO:0051371 muscle alpha-actinin binding 3/1822 15/18639 0.2 2.04599341383096 0.175396593951461 0.678017458493615 GO:0005452 solute:inorganic anion antiporter activity 5/1822 31/18639 0.161290322580645 1.64999468857335 0.180866179553643 0.693517964948683 GO:0120013 lipid transfer activity 9/1822 65/18639 0.138461538461538 1.41645697880605 0.181016549137398 0.693517964948683 GO:0015293 symporter activity 18/1822 146/18639 0.123287671232877 1.26122881674511 0.181088361098161 0.693517964948683 GO:0140103 catalytic activity, acting on a glycoprotein 4/1822 23/18639 0.173913043478261 1.77912470767909 0.181977857249791 0.694773485857998 GO:0042578 phosphoric ester hydrolase activity 41/1822 363/18639 0.112947658402204 1.15545082599269 0.183984130824573 0.700271907169222 GO:0015103 inorganic anion transmembrane transporter activity 20/1822 165/18639 0.121212121212121 1.2399960083824 0.185136698029351 0.702497225344501 GO:0004721 phosphoprotein phosphatase activity 21/1822 175/18639 0.12 1.22759604829857 0.190245059859507 0.719673208092386 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 6/1822 40/18639 0.15 1.53449506037322 0.191877450115407 0.721435883868567 GO:0030331 nuclear estrogen receptor binding 6/1822 40/18639 0.15 1.53449506037322 0.191877450115407 0.721435883868567 GO:0070851 growth factor receptor binding 17/1822 139/18639 0.122302158273381 1.25114705162325 0.1984163180049 0.732967862375069 GO:0035254 glutamate receptor binding 7/1822 49/18639 0.142857142857143 1.46142386702211 0.198525459378852 0.732967862375069 GO:0005024 transforming growth factor beta receptor activity 3/1822 16/18639 0.1875 1.91811882546652 0.201152099023806 0.732967862375069 GO:0015923 mannosidase activity 3/1822 16/18639 0.1875 1.91811882546652 0.201152099023806 0.732967862375069 GO:0016722 oxidoreductase activity, acting on metal ions 3/1822 16/18639 0.1875 1.91811882546652 0.201152099023806 0.732967862375069 GO:0070411 I-SMAD binding 3/1822 16/18639 0.1875 1.91811882546652 0.201152099023806 0.732967862375069 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 4/1822 24/18639 0.166666666666667 1.7049945115258 0.202647541578232 0.732967862375069 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 4/1822 24/18639 0.166666666666667 1.7049945115258 0.202647541578232 0.732967862375069 GO:0004622 lysophospholipase activity 4/1822 24/18639 0.166666666666667 1.7049945115258 0.202647541578232 0.732967862375069 GO:0015295 solute:proton symporter activity 4/1822 24/18639 0.166666666666667 1.7049945115258 0.202647541578232 0.732967862375069 GO:0030552 cAMP binding 4/1822 24/18639 0.166666666666667 1.7049945115258 0.202647541578232 0.732967862375069 GO:0035035 histone acetyltransferase binding 4/1822 24/18639 0.166666666666667 1.7049945115258 0.202647541578232 0.732967862375069 GO:0048027 mRNA 5'-UTR binding 4/1822 24/18639 0.166666666666667 1.7049945115258 0.202647541578232 0.732967862375069 GO:0008509 monoatomic anion transmembrane transporter activity 18/1822 149/18639 0.120805369127517 1.23583494795158 0.204407994468266 0.737179851770394 GO:0016247 channel regulator activity 20/1822 168/18639 0.119047619047619 1.21785322251843 0.207267742065981 0.744226141283284 GO:0017080 sodium channel regulator activity 6/1822 41/18639 0.146341463414634 1.49706835158363 0.207565091950471 0.744226141283284 GO:0005006 epidermal growth factor receptor activity 7/1822 50/18639 0.14 1.43219538968167 0.212838689717904 0.760929072777592 GO:0019239 deaminase activity 5/1822 33/18639 0.151515151515152 1.549995010478 0.21635809919294 0.769066002016283 GO:0140311 protein sequestering activity 5/1822 33/18639 0.151515151515152 1.549995010478 0.21635809919294 0.769066002016283 GO:0099106 ion channel regulator activity 19/1822 160/18639 0.11875 1.21480858946213 0.21780601472445 0.771994384567751 GO:0141108 transporter regulator activity 20/1822 170/18639 0.117647058823529 1.20352553754762 0.222685221727187 0.773845158754549 GO:0019894 kinesin binding 6/1822 42/18639 0.142857142857143 1.46142386702211 0.223687002036857 0.773845158754549 GO:0005537 D-mannose binding 4/1822 25/18639 0.16 1.63679473106476 0.223962989959481 0.773845158754549 GO:0015296 monoatomic anion:monoatomic cation symporter activity 4/1822 25/18639 0.16 1.63679473106476 0.223962989959481 0.773845158754549 GO:0042974 nuclear retinoic acid receptor binding 4/1822 25/18639 0.16 1.63679473106476 0.223962989959481 0.773845158754549 GO:0120020 cholesterol transfer activity 4/1822 25/18639 0.16 1.63679473106476 0.223962989959481 0.773845158754549 GO:0005010 insulin-like growth factor receptor activity 7/1822 51/18639 0.137254901960784 1.40411312713889 0.227515632442294 0.773845158754549 GO:0004549 tRNA-specific ribonuclease activity 3/1822 17/18639 0.176470588235294 1.80528830632143 0.227711914136343 0.773845158754549 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 3/1822 17/18639 0.176470588235294 1.80528830632143 0.227711914136343 0.773845158754549 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 3/1822 17/18639 0.176470588235294 1.80528830632143 0.227711914136343 0.773845158754549 GO:0005092 GDP-dissociation inhibitor activity 3/1822 17/18639 0.176470588235294 1.80528830632143 0.227711914136343 0.773845158754549 GO:0008484 sulfuric ester hydrolase activity 3/1822 17/18639 0.176470588235294 1.80528830632143 0.227711914136343 0.773845158754549 GO:0016018 cyclosporin A binding 3/1822 17/18639 0.176470588235294 1.80528830632143 0.227711914136343 0.773845158754549 GO:0019198 transmembrane receptor protein phosphatase activity 3/1822 17/18639 0.176470588235294 1.80528830632143 0.227711914136343 0.773845158754549 GO:0048038 quinone binding 3/1822 17/18639 0.176470588235294 1.80528830632143 0.227711914136343 0.773845158754549 GO:0001221 transcription coregulator binding 14/1822 115/18639 0.121739130434783 1.24538729537536 0.23197597039142 0.78617609691558 GO:0019207 kinase regulator activity 32/1822 287/18639 0.111498257839721 1.14062350596848 0.240776953280481 0.795142239855888 GO:0015370 solute:sodium symporter activity 10/1822 79/18639 0.126582278481013 1.29493254039934 0.241100768067986 0.795142239855888 GO:0033293 monocarboxylic acid binding 10/1822 79/18639 0.126582278481013 1.29493254039934 0.241100768067986 0.795142239855888 GO:0001217 DNA-binding transcription repressor activity 31/1822 278/18639 0.111510791366906 1.14075172353884 0.244798038629174 0.795142239855888 GO:0004112 cyclic-nucleotide phosphodiesterase activity 4/1822 26/18639 0.153846153846154 1.57384108756227 0.245819356075128 0.795142239855888 GO:0005112 Notch binding 4/1822 26/18639 0.153846153846154 1.57384108756227 0.245819356075128 0.795142239855888 GO:0030507 spectrin binding 4/1822 26/18639 0.153846153846154 1.57384108756227 0.245819356075128 0.795142239855888 GO:0004175 endopeptidase activity 44/1822 405/18639 0.108641975308642 1.11140382973533 0.250243502167391 0.795142239855888 GO:0099094 ligand-gated monoatomic cation channel activity 16/1822 136/18639 0.117647058823529 1.20352553754762 0.254008273641735 0.795142239855888 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 3/1822 18/18639 0.166666666666667 1.7049945115258 0.254872755244392 0.795142239855888 GO:0008525 phosphatidylcholine transporter activity 3/1822 18/18639 0.166666666666667 1.7049945115258 0.254872755244392 0.795142239855888 GO:0015172 acidic amino acid transmembrane transporter activity 3/1822 18/18639 0.166666666666667 1.7049945115258 0.254872755244392 0.795142239855888 GO:0030228 lipoprotein particle receptor activity 3/1822 18/18639 0.166666666666667 1.7049945115258 0.254872755244392 0.795142239855888 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 3/1822 18/18639 0.166666666666667 1.7049945115258 0.254872755244392 0.795142239855888 GO:0070064 proline-rich region binding 3/1822 18/18639 0.166666666666667 1.7049945115258 0.254872755244392 0.795142239855888 GO:0003680 minor groove of adenine-thymine-rich DNA binding 2/1822 10/18639 0.2 2.04599341383096 0.255191163478405 0.795142239855888 GO:0004090 carbonyl reductase (NADPH) activity 2/1822 10/18639 0.2 2.04599341383096 0.255191163478405 0.795142239855888 GO:0004935 adrenergic receptor activity 2/1822 10/18639 0.2 2.04599341383096 0.255191163478405 0.795142239855888 GO:0008519 ammonium channel activity 2/1822 10/18639 0.2 2.04599341383096 0.255191163478405 0.795142239855888 GO:0015279 store-operated calcium channel activity 2/1822 10/18639 0.2 2.04599341383096 0.255191163478405 0.795142239855888 GO:0015924 mannosyl-oligosaccharide mannosidase activity 2/1822 10/18639 0.2 2.04599341383096 0.255191163478405 0.795142239855888 GO:0016303 1-phosphatidylinositol-3-kinase activity 2/1822 10/18639 0.2 2.04599341383096 0.255191163478405 0.795142239855888 GO:0031720 haptoglobin binding 2/1822 10/18639 0.2 2.04599341383096 0.255191163478405 0.795142239855888 GO:0032356 oxidized DNA binding 2/1822 10/18639 0.2 2.04599341383096 0.255191163478405 0.795142239855888 GO:0033204 ribonuclease P RNA binding 2/1822 10/18639 0.2 2.04599341383096 0.255191163478405 0.795142239855888 GO:0043121 neurotrophin binding 2/1822 10/18639 0.2 2.04599341383096 0.255191163478405 0.795142239855888 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 2/1822 10/18639 0.2 2.04599341383096 0.255191163478405 0.795142239855888 GO:0043295 glutathione binding 2/1822 10/18639 0.2 2.04599341383096 0.255191163478405 0.795142239855888 GO:0047429 nucleoside triphosphate diphosphatase activity 2/1822 10/18639 0.2 2.04599341383096 0.255191163478405 0.795142239855888 GO:0051880 G-quadruplex DNA binding 2/1822 10/18639 0.2 2.04599341383096 0.255191163478405 0.795142239855888 GO:0070097 delta-catenin binding 2/1822 10/18639 0.2 2.04599341383096 0.255191163478405 0.795142239855888 GO:1905394 retromer complex binding 2/1822 10/18639 0.2 2.04599341383096 0.255191163478405 0.795142239855888 GO:0005003 ephrin receptor activity 7/1822 53/18639 0.132075471698113 1.35112772611478 0.257835916481616 0.797357571719398 GO:0005005 transmembrane-ephrin receptor activity 7/1822 53/18639 0.132075471698113 1.35112772611478 0.257835916481616 0.797357571719398 GO:0017046 peptide hormone binding 7/1822 53/18639 0.132075471698113 1.35112772611478 0.257835916481616 0.797357571719398 GO:0016922 nuclear receptor binding 16/1822 137/18639 0.116788321167883 1.19474067960932 0.263473095776713 0.812758652059337 GO:0030971 receptor tyrosine kinase binding 10/1822 81/18639 0.123456790123457 1.26295889742652 0.265802622263326 0.816887104680185 GO:1901981 phosphatidylinositol phosphate binding 21/1822 185/18639 0.113513513513514 1.1612395051473 0.266999467947357 0.816887104680185 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 15/1822 128/18639 0.1171875 1.19882426591658 0.267897593765646 0.816887104680185 GO:0004683 calcium/calmodulin-dependent protein kinase activity 4/1822 27/18639 0.148148148148148 1.51555067691182 0.268113310024378 0.816887104680185 GO:0015252 proton channel activity 4/1822 27/18639 0.148148148148148 1.51555067691182 0.268113310024378 0.816887104680185 GO:0050661 NADP binding 7/1822 54/18639 0.12962962962963 1.32610684229784 0.273415055383982 0.830993669557703 GO:0072341 modified amino acid binding 11/1822 91/18639 0.120879120879121 1.23658942594179 0.274401417047565 0.831460957425349 GO:0015276 ligand-gated monoatomic ion channel activity 21/1822 186/18639 0.112903225806452 1.15499628200135 0.275270548831929 0.831460957425349 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 9/1822 73/18639 0.123287671232877 1.26122881674511 0.282355371559516 0.831460957425349 GO:0005229 intracellularly calcium-gated chloride channel activity 3/1822 19/18639 0.157894736842105 1.6152579582876 0.282443831386093 0.831460957425349 GO:0030506 ankyrin binding 3/1822 19/18639 0.157894736842105 1.6152579582876 0.282443831386093 0.831460957425349 GO:0042800 histone H3K4 methyltransferase activity 3/1822 19/18639 0.157894736842105 1.6152579582876 0.282443831386093 0.831460957425349 GO:0042834 peptidoglycan binding 3/1822 19/18639 0.157894736842105 1.6152579582876 0.282443831386093 0.831460957425349 GO:0046624 sphingolipid transporter activity 3/1822 19/18639 0.157894736842105 1.6152579582876 0.282443831386093 0.831460957425349 GO:0141147 intracellularly calcium-gated channel activity 3/1822 19/18639 0.157894736842105 1.6152579582876 0.282443831386093 0.831460957425349 GO:0052689 carboxylic ester hydrolase activity 11/1822 92/18639 0.119565217391304 1.22314823652938 0.286466713739039 0.831460957425349 GO:0046625 sphingolipid binding 4/1822 28/18639 0.142857142857143 1.46142386702211 0.290744152784514 0.831460957425349 GO:0050698 proteoglycan sulfotransferase activity 4/1822 28/18639 0.142857142857143 1.46142386702211 0.290744152784514 0.831460957425349 GO:0051019 mitogen-activated protein kinase binding 4/1822 28/18639 0.142857142857143 1.46142386702211 0.290744152784514 0.831460957425349 GO:0097718 disordered domain specific binding 4/1822 28/18639 0.142857142857143 1.46142386702211 0.290744152784514 0.831460957425349 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 6/1822 46/18639 0.130434782608696 1.33434353075932 0.291652466934473 0.831460957425349 GO:0022834 ligand-gated channel activity 21/1822 188/18639 0.111702127659574 1.14270908751197 0.292084254123543 0.831460957425349 GO:0042805 actinin binding 5/1822 37/18639 0.135135135135135 1.38242798231821 0.292624805348478 0.831460957425349 GO:0001851 complement component C3b binding 2/1822 11/18639 0.181818181818182 1.8599940125736 0.293061420725507 0.831460957425349 GO:0002162 dystroglycan binding 2/1822 11/18639 0.181818181818182 1.8599940125736 0.293061420725507 0.831460957425349 GO:0008172 S-methyltransferase activity 2/1822 11/18639 0.181818181818182 1.8599940125736 0.293061420725507 0.831460957425349 GO:0008199 ferric iron binding 2/1822 11/18639 0.181818181818182 1.8599940125736 0.293061420725507 0.831460957425349 GO:0008271 secondary active sulfate transmembrane transporter activity 2/1822 11/18639 0.181818181818182 1.8599940125736 0.293061420725507 0.831460957425349 GO:0008432 JUN kinase binding 2/1822 11/18639 0.181818181818182 1.8599940125736 0.293061420725507 0.831460957425349 GO:0008503 benzodiazepine receptor activity 2/1822 11/18639 0.181818181818182 1.8599940125736 0.293061420725507 0.831460957425349 GO:0008526 phosphatidylinositol transfer activity 2/1822 11/18639 0.181818181818182 1.8599940125736 0.293061420725507 0.831460957425349 GO:0015217 ADP transmembrane transporter activity 2/1822 11/18639 0.181818181818182 1.8599940125736 0.293061420725507 0.831460957425349 GO:0034713 type I transforming growth factor beta receptor binding 2/1822 11/18639 0.181818181818182 1.8599940125736 0.293061420725507 0.831460957425349 GO:0048185 activin binding 2/1822 11/18639 0.181818181818182 1.8599940125736 0.293061420725507 0.831460957425349 GO:1900750 oligopeptide binding 2/1822 11/18639 0.181818181818182 1.8599940125736 0.293061420725507 0.831460957425349 GO:0008017 microtubule binding 30/1822 276/18639 0.108695652173913 1.11195294229943 0.296642416425171 0.839694895006719 GO:0008528 G protein-coupled peptide receptor activity 14/1822 122/18639 0.114754098360656 1.17393064728006 0.304191242669584 0.850245071884982 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 7/1822 56/18639 0.125 1.27874588364435 0.305247688939649 0.850245071884982 GO:0170055 lipid transmembrane transporter activity 7/1822 56/18639 0.125 1.27874588364435 0.305247688939649 0.850245071884982 GO:0016853 isomerase activity 20/1822 180/18639 0.111111111111111 1.13666300768386 0.306540721735182 0.850245071884982 GO:0005504 fatty acid binding 6/1822 47/18639 0.127659574468085 1.30595324287082 0.309293050270356 0.850245071884982 GO:0140359 ABC-type transporter activity 6/1822 47/18639 0.127659574468085 1.30595324287082 0.309293050270356 0.850245071884982 GO:0140938 histone H3 methyltransferase activity 6/1822 47/18639 0.127659574468085 1.30595324287082 0.309293050270356 0.850245071884982 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 29/1822 268/18639 0.108208955223881 1.10697404852794 0.309340263707702 0.850245071884982 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 3/1822 20/18639 0.15 1.53449506037322 0.31024825216981 0.850245071884982 GO:0030742 GTP-dependent protein binding 3/1822 20/18639 0.15 1.53449506037322 0.31024825216981 0.850245071884982 GO:0000146 microfilament motor activity 5/1822 38/18639 0.131578947368421 1.346048298573 0.312421162243548 0.850245071884982 GO:0042887 amide transmembrane transporter activity 5/1822 38/18639 0.131578947368421 1.346048298573 0.312421162243548 0.850245071884982 GO:0043531 ADP binding 5/1822 38/18639 0.131578947368421 1.346048298573 0.312421162243548 0.850245071884982 GO:0140996 histone H3 kinase activity 38/1822 357/18639 0.106442577030812 1.08890405778118 0.313376876308885 0.850245071884982 GO:0035250 UDP-galactosyltransferase activity 4/1822 29/18639 0.137931034482759 1.41102994057307 0.313614740693142 0.850245071884982 GO:0022836 gated channel activity 34/1822 318/18639 0.106918238993711 1.09377006399768 0.315884708822745 0.850245071884982 GO:0005267 potassium channel activity 14/1822 124/18639 0.112903225806452 1.15499628200135 0.325924659730131 0.850245071884982 GO:0038187 pattern recognition receptor activity 6/1822 48/18639 0.125 1.27874588364435 0.32710550675959 0.850245071884982 GO:0004526 ribonuclease P activity 2/1822 12/18639 0.166666666666667 1.7049945115258 0.330648687860476 0.850245071884982 GO:0004875 complement receptor activity 2/1822 12/18639 0.166666666666667 1.7049945115258 0.330648687860476 0.850245071884982 GO:0005025 transforming growth factor beta receptor activity, type I 2/1822 12/18639 0.166666666666667 1.7049945115258 0.330648687860476 0.850245071884982 GO:0005026 transforming growth factor beta receptor activity, type II 2/1822 12/18639 0.166666666666667 1.7049945115258 0.330648687860476 0.850245071884982 GO:0005095 GTPase inhibitor activity 2/1822 12/18639 0.166666666666667 1.7049945115258 0.330648687860476 0.850245071884982 GO:0005165 neurotrophin receptor binding 2/1822 12/18639 0.166666666666667 1.7049945115258 0.330648687860476 0.850245071884982 GO:0008504 monoamine transmembrane transporter activity 2/1822 12/18639 0.166666666666667 1.7049945115258 0.330648687860476 0.850245071884982 GO:0015166 polyol transmembrane transporter activity 2/1822 12/18639 0.166666666666667 1.7049945115258 0.330648687860476 0.850245071884982 GO:0015269 calcium-activated potassium channel activity 2/1822 12/18639 0.166666666666667 1.7049945115258 0.330648687860476 0.850245071884982 GO:0016361 activin receptor activity, type I 2/1822 12/18639 0.166666666666667 1.7049945115258 0.330648687860476 0.850245071884982 GO:0016362 activin receptor activity, type II 2/1822 12/18639 0.166666666666667 1.7049945115258 0.330648687860476 0.850245071884982 GO:0017002 activin receptor activity 2/1822 12/18639 0.166666666666667 1.7049945115258 0.330648687860476 0.850245071884982 GO:0017166 vinculin binding 2/1822 12/18639 0.166666666666667 1.7049945115258 0.330648687860476 0.850245071884982 GO:0031543 peptidyl-proline dioxygenase activity 2/1822 12/18639 0.166666666666667 1.7049945115258 0.330648687860476 0.850245071884982 GO:0034452 dynactin binding 2/1822 12/18639 0.166666666666667 1.7049945115258 0.330648687860476 0.850245071884982 GO:0035251 UDP-glucosyltransferase activity 2/1822 12/18639 0.166666666666667 1.7049945115258 0.330648687860476 0.850245071884982 GO:0042301 phosphate ion binding 2/1822 12/18639 0.166666666666667 1.7049945115258 0.330648687860476 0.850245071884982 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 2/1822 12/18639 0.166666666666667 1.7049945115258 0.330648687860476 0.850245071884982 GO:0070679 inositol 1,4,5 trisphosphate binding 2/1822 12/18639 0.166666666666667 1.7049945115258 0.330648687860476 0.850245071884982 GO:0097677 STAT family protein binding 2/1822 12/18639 0.166666666666667 1.7049945115258 0.330648687860476 0.850245071884982 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 2/1822 12/18639 0.166666666666667 1.7049945115258 0.330648687860476 0.850245071884982 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 2/1822 12/18639 0.166666666666667 1.7049945115258 0.330648687860476 0.850245071884982 GO:0140829 bicarbonate:monoatomic anion antiporter activity 2/1822 12/18639 0.166666666666667 1.7049945115258 0.330648687860476 0.850245071884982 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 2/1822 12/18639 0.166666666666667 1.7049945115258 0.330648687860476 0.850245071884982 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 2/1822 12/18639 0.166666666666667 1.7049945115258 0.330648687860476 0.850245071884982 GO:0140900 chloride:bicarbonate antiporter activity 2/1822 12/18639 0.166666666666667 1.7049945115258 0.330648687860476 0.850245071884982 GO:0035173 histone kinase activity 38/1822 360/18639 0.105555555555556 1.07982985729967 0.332560457372065 0.850245071884982 GO:0019001 guanyl nucleotide binding 42/1822 400/18639 0.105 1.07414654226125 0.334902449189938 0.850245071884982 GO:0032561 guanyl ribonucleotide binding 42/1822 400/18639 0.105 1.07414654226125 0.334902449189938 0.850245071884982 GO:0008106 alcohol dehydrogenase (NADP+) activity 4/1822 30/18639 0.133333333333333 1.36399560922064 0.336632234291887 0.850245071884982 GO:0016769 transferase activity, transferring nitrogenous groups 4/1822 30/18639 0.133333333333333 1.36399560922064 0.336632234291887 0.850245071884982 GO:0070566 adenylyltransferase activity 4/1822 30/18639 0.133333333333333 1.36399560922064 0.336632234291887 0.850245071884982 GO:0005261 monoatomic cation channel activity 36/1822 341/18639 0.105571847507331 1.07999652342983 0.337759166380387 0.850245071884982 GO:0008373 sialyltransferase activity 3/1822 21/18639 0.142857142857143 1.46142386702211 0.338123855297227 0.850245071884982 GO:0015174 basic amino acid transmembrane transporter activity 3/1822 21/18639 0.142857142857143 1.46142386702211 0.338123855297227 0.850245071884982 GO:0051010 microtubule plus-end binding 3/1822 21/18639 0.142857142857143 1.46142386702211 0.338123855297227 0.850245071884982 GO:0008237 metallopeptidase activity 20/1822 184/18639 0.108695652173913 1.11195294229943 0.34254524860021 0.850245071884982 GO:0005004 GPI-linked ephrin receptor activity 6/1822 49/18639 0.122448979591837 1.25264902887609 0.345046908719693 0.850245071884982 GO:0005008 hepatocyte growth factor receptor activity 6/1822 49/18639 0.122448979591837 1.25264902887609 0.345046908719693 0.850245071884982 GO:0005009 insulin receptor activity 6/1822 49/18639 0.122448979591837 1.25264902887609 0.345046908719693 0.850245071884982 GO:0005011 macrophage colony-stimulating factor receptor activity 6/1822 49/18639 0.122448979591837 1.25264902887609 0.345046908719693 0.850245071884982 GO:0005018 platelet-derived growth factor alpha-receptor activity 6/1822 49/18639 0.122448979591837 1.25264902887609 0.345046908719693 0.850245071884982 GO:0005020 stem cell factor receptor activity 6/1822 49/18639 0.122448979591837 1.25264902887609 0.345046908719693 0.850245071884982 GO:0008288 boss receptor activity 6/1822 49/18639 0.122448979591837 1.25264902887609 0.345046908719693 0.850245071884982 GO:0036332 placental growth factor receptor activity 6/1822 49/18639 0.122448979591837 1.25264902887609 0.345046908719693 0.850245071884982 GO:0038062 protein tyrosine kinase collagen receptor activity 6/1822 49/18639 0.122448979591837 1.25264902887609 0.345046908719693 0.850245071884982 GO:0060175 brain-derived neurotrophic factor receptor activity 6/1822 49/18639 0.122448979591837 1.25264902887609 0.345046908719693 0.850245071884982 GO:1990841 promoter-specific chromatin binding 8/1822 68/18639 0.117647058823529 1.20352553754762 0.345853564946467 0.85053848874509 GO:0015144 carbohydrate transmembrane transporter activity 5/1822 40/18639 0.125 1.27874588364435 0.352457775096342 0.861323444857849 GO:0001786 phosphatidylserine binding 7/1822 59/18639 0.11864406779661 1.21372490650989 0.354190307349244 0.861323444857849 GO:0035091 phosphatidylinositol binding 30/1822 284/18639 0.105633802816901 1.08063032420649 0.354629186463659 0.861323444857849 GO:0019208 phosphatase regulator activity 13/1822 117/18639 0.111111111111111 1.13666300768386 0.35623054649106 0.861323444857849 GO:0004197 cysteine-type endopeptidase activity 10/1822 88/18639 0.113636363636364 1.1624962578585 0.357310233399274 0.861323444857849 GO:0005310 dicarboxylic acid transmembrane transporter activity 4/1822 31/18639 0.129032258064516 1.31999575085868 0.359708686845701 0.861323444857849 GO:0019887 protein kinase regulator activity 27/1822 255/18639 0.105882352941176 1.08317298379286 0.359990984659158 0.861323444857849 GO:0005249 voltage-gated potassium channel activity 11/1822 98/18639 0.112244897959184 1.14826160980309 0.361491699564911 0.861323444857849 GO:0005007 fibroblast growth factor receptor activity 6/1822 50/18639 0.12 1.22759604829857 0.363075302219938 0.861323444857849 GO:0005017 platelet-derived growth factor receptor activity 6/1822 50/18639 0.12 1.22759604829857 0.363075302219938 0.861323444857849 GO:0005019 platelet-derived growth factor beta-receptor activity 6/1822 50/18639 0.12 1.22759604829857 0.363075302219938 0.861323444857849 GO:0015631 tubulin binding 40/1822 385/18639 0.103896103896104 1.06285372147063 0.365671979248233 0.861323444857849 GO:0061133 endopeptidase activator activity 3/1822 22/18639 0.136363636363636 1.3949955094302 0.365923572027745 0.861323444857849 GO:0009982 pseudouridine synthase activity 2/1822 13/18639 0.153846153846154 1.57384108756227 0.367646547198823 0.861323444857849 GO:0015651 quaternary ammonium group transmembrane transporter activity 2/1822 13/18639 0.153846153846154 1.57384108756227 0.367646547198823 0.861323444857849 GO:0031432 titin binding 2/1822 13/18639 0.153846153846154 1.57384108756227 0.367646547198823 0.861323444857849 GO:0035325 Toll-like receptor binding 2/1822 13/18639 0.153846153846154 1.57384108756227 0.367646547198823 0.861323444857849 GO:0035673 oligopeptide transmembrane transporter activity 2/1822 13/18639 0.153846153846154 1.57384108756227 0.367646547198823 0.861323444857849 GO:0039706 co-receptor binding 2/1822 13/18639 0.153846153846154 1.57384108756227 0.367646547198823 0.861323444857849 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 2/1822 13/18639 0.153846153846154 1.57384108756227 0.367646547198823 0.861323444857849 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 2/1822 13/18639 0.153846153846154 1.57384108756227 0.367646547198823 0.861323444857849 GO:0070123 transforming growth factor beta receptor activity, type III 2/1822 13/18639 0.153846153846154 1.57384108756227 0.367646547198823 0.861323444857849 GO:0070700 BMP receptor binding 2/1822 13/18639 0.153846153846154 1.57384108756227 0.367646547198823 0.861323444857849 GO:0140852 histone ubiquitin ligase activity 2/1822 13/18639 0.153846153846154 1.57384108756227 0.367646547198823 0.861323444857849 GO:1901338 catecholamine binding 2/1822 13/18639 0.153846153846154 1.57384108756227 0.367646547198823 0.861323444857849 GO:0001653 peptide receptor activity 14/1822 128/18639 0.109375 1.1189026481888 0.370365041404089 0.865184919485989 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 7/1822 60/18639 0.116666666666667 1.19349615806806 0.37069361950491 0.865184919485989 GO:0019209 kinase activator activity 16/1822 148/18639 0.108108108108108 1.10594238585457 0.374304377084098 0.871967070533013 GO:0005021 vascular endothelial growth factor receptor activity 6/1822 51/18639 0.117647058823529 1.20352553754762 0.381149924856957 0.881705700081105 GO:0005030 neurotrophin receptor activity 6/1822 51/18639 0.117647058823529 1.20352553754762 0.381149924856957 0.881705700081105 GO:0008378 galactosyltransferase activity 4/1822 32/18639 0.125 1.27874588364435 0.38276148823246 0.881705700081105 GO:0022884 macromolecule transmembrane transporter activity 4/1822 32/18639 0.125 1.27874588364435 0.38276148823246 0.881705700081105 GO:0042910 xenobiotic transmembrane transporter activity 4/1822 32/18639 0.125 1.27874588364435 0.38276148823246 0.881705700081105 GO:0051059 NF-kappaB binding 4/1822 32/18639 0.125 1.27874588364435 0.38276148823246 0.881705700081105 GO:0140297 DNA-binding transcription factor binding 50/1822 488/18639 0.102459016393443 1.04815236364291 0.383766402630437 0.882039533892321 GO:0019210 kinase inhibitor activity 10/1822 90/18639 0.111111111111111 1.13666300768386 0.384332505067066 0.882039533892321 GO:0005525 GTP binding 39/1822 378/18639 0.103174603174603 1.0554727928493 0.385172196977718 0.882329643817476 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 36/1822 349/18639 0.103151862464183 1.05524015613058 0.392108551254961 0.888282091195932 GO:0035198 miRNA binding 5/1822 42/18639 0.119047619047619 1.21785322251843 0.392702671951701 0.888282091195932 GO:0051879 Hsp90 protein binding 5/1822 42/18639 0.119047619047619 1.21785322251843 0.392702671951701 0.888282091195932 GO:0004022 alcohol dehydrogenase (NAD+) activity 3/1822 23/18639 0.130434782608696 1.33434353075932 0.393515429244439 0.888282091195932 GO:0005158 insulin receptor binding 3/1822 23/18639 0.130434782608696 1.33434353075932 0.393515429244439 0.888282091195932 GO:0016849 phosphorus-oxygen lyase activity 3/1822 23/18639 0.130434782608696 1.33434353075932 0.393515429244439 0.888282091195932 GO:0031681 G-protein beta-subunit binding 3/1822 23/18639 0.130434782608696 1.33434353075932 0.393515429244439 0.888282091195932 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 3/1822 23/18639 0.130434782608696 1.33434353075932 0.393515429244439 0.888282091195932 GO:0015079 potassium ion transmembrane transporter activity 17/1822 160/18639 0.10625 1.08693400109769 0.396229315425616 0.890399943424005 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 6/1822 52/18639 0.115384615384615 1.1803808156717 0.399231396440157 0.890399943424005 GO:0005313 L-glutamate transmembrane transporter activity 2/1822 14/18639 0.142857142857143 1.46142386702211 0.403811130364484 0.890399943424005 GO:0005344 oxygen carrier activity 2/1822 14/18639 0.142857142857143 1.46142386702211 0.403811130364484 0.890399943424005 GO:0005347 ATP transmembrane transporter activity 2/1822 14/18639 0.142857142857143 1.46142386702211 0.403811130364484 0.890399943424005 GO:0016530 metallochaperone activity 2/1822 14/18639 0.142857142857143 1.46142386702211 0.403811130364484 0.890399943424005 GO:0019763 immunoglobulin receptor activity 2/1822 14/18639 0.142857142857143 1.46142386702211 0.403811130364484 0.890399943424005 GO:0031404 chloride ion binding 2/1822 14/18639 0.142857142857143 1.46142386702211 0.403811130364484 0.890399943424005 GO:0046030 inositol trisphosphate phosphatase activity 2/1822 14/18639 0.142857142857143 1.46142386702211 0.403811130364484 0.890399943424005 GO:0061783 peptidoglycan muralytic activity 2/1822 14/18639 0.142857142857143 1.46142386702211 0.403811130364484 0.890399943424005 GO:0070742 C2H2 zinc finger domain binding 2/1822 14/18639 0.142857142857143 1.46142386702211 0.403811130364484 0.890399943424005 GO:0098821 BMP receptor activity 2/1822 14/18639 0.142857142857143 1.46142386702211 0.403811130364484 0.890399943424005 GO:1901474 azole transmembrane transporter activity 2/1822 14/18639 0.142857142857143 1.46142386702211 0.403811130364484 0.890399943424005 GO:0008200 ion channel inhibitor activity 5/1822 43/18639 0.116279069767442 1.18953105455288 0.412768747557919 0.908390346265443 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 13/1822 122/18639 0.10655737704918 1.09007845818862 0.414925210800342 0.908390346265443 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 14/1822 132/18639 0.106060606060606 1.0849965073346 0.415582688022533 0.908390346265443 GO:0005246 calcium channel regulator activity 6/1822 53/18639 0.113207547169811 1.15810947952696 0.417281883243375 0.908390346265443 GO:0038064 collagen receptor activity 6/1822 53/18639 0.113207547169811 1.15810947952696 0.417281883243375 0.908390346265443 GO:1901505 carbohydrate derivative transmembrane transporter activity 6/1822 53/18639 0.113207547169811 1.15810947952696 0.417281883243375 0.908390346265443 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 6/1822 53/18639 0.113207547169811 1.15810947952696 0.417281883243375 0.908390346265443 GO:0001091 RNA polymerase II general transcription initiation factor binding 3/1822 24/18639 0.125 1.27874588364435 0.420782270339611 0.908390346265443 GO:0004806 triacylglycerol lipase activity 3/1822 24/18639 0.125 1.27874588364435 0.420782270339611 0.908390346265443 GO:0070300 phosphatidic acid binding 3/1822 24/18639 0.125 1.27874588364435 0.420782270339611 0.908390346265443 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 3/1822 24/18639 0.125 1.27874588364435 0.420782270339611 0.908390346265443 GO:0070840 dynein complex binding 3/1822 24/18639 0.125 1.27874588364435 0.420782270339611 0.908390346265443 GO:0141003 histone H2AX kinase activity 36/1822 354/18639 0.101694915254237 1.04033563415133 0.42680297231733 0.919782712119403 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 4/1822 34/18639 0.117647058823529 1.20352553754762 0.428494155567686 0.920220955620187 GO:0019825 oxygen binding 4/1822 34/18639 0.117647058823529 1.20352553754762 0.428494155567686 0.920220955620187 GO:0016248 channel inhibitor activity 5/1822 44/18639 0.113636363636364 1.1624962578585 0.432731151040967 0.925014329770291 GO:0030547 signaling receptor inhibitor activity 5/1822 44/18639 0.113636363636364 1.1624962578585 0.432731151040967 0.925014329770291 GO:0051020 GTPase binding 32/1822 315/18639 0.101587301587302 1.03923474988239 0.436514073220134 0.925014329770291 GO:0004860 protein kinase inhibitor activity 9/1822 84/18639 0.107142857142857 1.09606790026658 0.438371040410455 0.925014329770291 GO:0005041 low-density lipoprotein particle receptor activity 2/1822 15/18639 0.133333333333333 1.36399560922064 0.43895182827418 0.925014329770291 GO:0008242 omega peptidase activity 2/1822 15/18639 0.133333333333333 1.36399560922064 0.43895182827418 0.925014329770291 GO:0015116 sulfate transmembrane transporter activity 2/1822 15/18639 0.133333333333333 1.36399560922064 0.43895182827418 0.925014329770291 GO:0017081 chloride channel regulator activity 2/1822 15/18639 0.133333333333333 1.36399560922064 0.43895182827418 0.925014329770291 GO:0030553 cGMP binding 2/1822 15/18639 0.133333333333333 1.36399560922064 0.43895182827418 0.925014329770291 GO:0034483 heparan sulfate sulfotransferase activity 2/1822 15/18639 0.133333333333333 1.36399560922064 0.43895182827418 0.925014329770291 GO:0047372 monoacylglycerol lipase activity 2/1822 15/18639 0.133333333333333 1.36399560922064 0.43895182827418 0.925014329770291 GO:0005216 monoatomic ion channel activity 45/1822 448/18639 0.100446428571429 1.02756365649992 0.446644351387538 0.93848729233535 GO:0005251 delayed rectifier potassium channel activity 3/1822 25/18639 0.12 1.22759604829857 0.44762126311872 0.93848729233535 GO:0008483 transaminase activity 3/1822 25/18639 0.12 1.22759604829857 0.44762126311872 0.93848729233535 GO:0140566 histone reader activity 4/1822 35/18639 0.114285714285714 1.16913909361769 0.451037763814598 0.94405027722277 GO:0141110 transporter inhibitor activity 5/1822 45/18639 0.111111111111111 1.13666300768386 0.452544118301113 0.945113185194185 GO:0019003 GDP binding 8/1822 75/18639 0.106666666666667 1.09119648737651 0.453073661131893 0.945113185194185 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 9/1822 86/18639 0.104651162790698 1.07057794909759 0.46698047872132 0.95795392398618 GO:0017022 myosin binding 8/1822 76/18639 0.105263157894737 1.0768386388584 0.468272013372467 0.95795392398618 GO:0008235 metalloexopeptidase activity 7/1822 66/18639 0.106060606060606 1.0849965073346 0.469583005187541 0.95795392398618 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 5/1822 46/18639 0.108695652173913 1.11195294229943 0.472165051394606 0.95795392398618 GO:0008514 organic anion transmembrane transporter activity 27/1822 269/18639 0.100371747211896 1.02679966865122 0.472375341963015 0.95795392398618 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 2/1822 16/18639 0.125 1.27874588364435 0.47292321816709 0.95795392398618 GO:0005159 insulin-like growth factor receptor binding 2/1822 16/18639 0.125 1.27874588364435 0.47292321816709 0.95795392398618 GO:0005324 long-chain fatty acid transmembrane transporter activity 2/1822 16/18639 0.125 1.27874588364435 0.47292321816709 0.95795392398618 GO:0008142 oxysterol binding 2/1822 16/18639 0.125 1.27874588364435 0.47292321816709 0.95795392398618 GO:0015378 sodium:chloride symporter activity 2/1822 16/18639 0.125 1.27874588364435 0.47292321816709 0.95795392398618 GO:0022841 potassium ion leak channel activity 2/1822 16/18639 0.125 1.27874588364435 0.47292321816709 0.95795392398618 GO:0031435 mitogen-activated protein kinase kinase kinase binding 2/1822 16/18639 0.125 1.27874588364435 0.47292321816709 0.95795392398618 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 2/1822 16/18639 0.125 1.27874588364435 0.47292321816709 0.95795392398618 GO:0004033 aldo-keto reductase (NADPH) activity 4/1822 36/18639 0.111111111111111 1.13666300768386 0.473285323615485 0.95795392398618 GO:0005227 calcium-activated cation channel activity 3/1822 26/18639 0.115384615384615 1.1803808156717 0.473943250993971 0.95795392398618 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 3/1822 26/18639 0.115384615384615 1.1803808156717 0.473943250993971 0.95795392398618 GO:0008198 ferrous iron binding 3/1822 26/18639 0.115384615384615 1.1803808156717 0.473943250993971 0.95795392398618 GO:0050681 nuclear androgen receptor binding 3/1822 26/18639 0.115384615384615 1.1803808156717 0.473943250993971 0.95795392398618 GO:0070412 R-SMAD binding 3/1822 26/18639 0.115384615384615 1.1803808156717 0.473943250993971 0.95795392398618 GO:0043495 protein-membrane adaptor activity 5/1822 47/18639 0.106382978723404 1.08829436905902 0.491554575337969 0.990314348034312 GO:0099095 ligand-gated monoatomic anion channel activity 5/1822 47/18639 0.106382978723404 1.08829436905902 0.491554575337969 0.990314348034312 GO:0030295 protein kinase activator activity 14/1822 139/18639 0.100719424460432 1.03035639545444 0.494750248528573 0.994386483652739 GO:0030551 cyclic nucleotide binding 4/1822 37/18639 0.108108108108108 1.10594238585457 0.495183568253911 0.994386483652739 GO:0001671 ATPase activator activity 3/1822 27/18639 0.111111111111111 1.13666300768386 0.49967199361517 0.995278776300532 GO:0008266 poly(U) RNA binding 3/1822 27/18639 0.111111111111111 1.13666300768386 0.49967199361517 0.995278776300532 GO:0008320 protein transmembrane transporter activity 3/1822 27/18639 0.111111111111111 1.13666300768386 0.49967199361517 0.995278776300532 GO:0030145 manganese ion binding 7/1822 68/18639 0.102941176470588 1.05308484535417 0.501844231582834 0.995278776300532 GO:0016791 phosphatase activity 27/1822 273/18639 0.0989010989010989 1.01175498486146 0.504546087957184 0.995278776300532 GO:0008429 phosphatidylethanolamine binding 2/1822 17/18639 0.117647058823529 1.20352553754762 0.505618058704523 0.995278776300532 GO:0016805 dipeptidase activity 2/1822 17/18639 0.117647058823529 1.20352553754762 0.505618058704523 0.995278776300532 GO:0032183 SUMO binding 2/1822 17/18639 0.117647058823529 1.20352553754762 0.505618058704523 0.995278776300532 GO:0038191 neuropilin binding 2/1822 17/18639 0.117647058823529 1.20352553754762 0.505618058704523 0.995278776300532 GO:0051787 misfolded protein binding 2/1822 17/18639 0.117647058823529 1.20352553754762 0.505618058704523 0.995278776300532 GO:0070402 NADPH binding 2/1822 17/18639 0.117647058823529 1.20352553754762 0.505618058704523 0.995278776300532 GO:0070403 NAD+ binding 2/1822 17/18639 0.117647058823529 1.20352553754762 0.505618058704523 0.995278776300532 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 18/1822 181/18639 0.0994475138121547 1.01734479140766 0.506087591182728 0.995278776300532 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 5/1822 48/18639 0.104166666666667 1.06562156970362 0.510676560056385 0.999999999999945 GO:0032266 phosphatidylinositol-3-phosphate binding 5/1822 48/18639 0.104166666666667 1.06562156970362 0.510676560056385 0.999999999999945 GO:0004222 metalloendopeptidase activity 11/1822 110/18639 0.1 1.02299670691548 0.515260695526429 0.999999999999945 GO:0098960 postsynaptic neurotransmitter receptor activity 7/1822 69/18639 0.101449275362319 1.03782274614614 0.517734821725211 0.999999999999945 GO:0004879 nuclear receptor activity 6/1822 59/18639 0.101694915254237 1.04033563415133 0.523040274228247 0.999999999999945 GO:0015459 potassium channel regulator activity 6/1822 59/18639 0.101694915254237 1.04033563415133 0.523040274228247 0.999999999999945 GO:0004540 RNA nuclease activity 12/1822 121/18639 0.0991735537190083 1.01454218867651 0.523845873846593 0.999999999999945 GO:0016866 intramolecular transferase activity 3/1822 28/18639 0.107142857142857 1.09606790026658 0.524743334514849 0.999999999999945 GO:0051959 dynein light intermediate chain binding 3/1822 28/18639 0.107142857142857 1.09606790026658 0.524743334514849 0.999999999999945 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 3/1822 28/18639 0.107142857142857 1.09606790026658 0.524743334514849 0.999999999999945 GO:1902936 phosphatidylinositol bisphosphate binding 11/1822 111/18639 0.0990990990990991 1.01378052036669 0.527747056197082 0.999999999999945 GO:0060590 ATPase regulator activity 5/1822 49/18639 0.102040816326531 1.04387419073008 0.529498111344646 0.999999999999945 GO:0008028 monocarboxylic acid transmembrane transporter activity 7/1822 70/18639 0.1 1.02299670691548 0.533437766234319 0.999999999999945 GO:0003746 translation elongation factor activity 2/1822 18/18639 0.111111111111111 1.13666300768386 0.53696122163704 0.999999999999945 GO:0004706 JUN kinase kinase kinase activity 2/1822 18/18639 0.111111111111111 1.13666300768386 0.53696122163704 0.999999999999945 GO:0004970 glutamate-gated receptor activity 2/1822 18/18639 0.111111111111111 1.13666300768386 0.53696122163704 0.999999999999945 GO:0005372 water transmembrane transporter activity 2/1822 18/18639 0.111111111111111 1.13666300768386 0.53696122163704 0.999999999999945 GO:0015373 monoatomic anion:sodium symporter activity 2/1822 18/18639 0.111111111111111 1.13666300768386 0.53696122163704 0.999999999999945 GO:0017128 phospholipid scramblase activity 2/1822 18/18639 0.111111111111111 1.13666300768386 0.53696122163704 0.999999999999945 GO:0032393 MHC class I receptor activity 2/1822 18/18639 0.111111111111111 1.13666300768386 0.53696122163704 0.999999999999945 GO:0035615 clathrin adaptor activity 2/1822 18/18639 0.111111111111111 1.13666300768386 0.53696122163704 0.999999999999945 GO:0099602 neurotransmitter receptor regulator activity 2/1822 18/18639 0.111111111111111 1.13666300768386 0.53696122163704 0.999999999999945 GO:0000217 DNA secondary structure binding 4/1822 39/18639 0.102564102564103 1.04922739170818 0.537747861305778 0.999999999999945 GO:0022843 voltage-gated monoatomic cation channel activity 14/1822 143/18639 0.0979020979020979 1.00153523753963 0.539037643430891 0.999999999999945 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 6/1822 60/18639 0.1 1.02299670691548 0.539967680308618 0.999999999999945 GO:0098531 ligand-modulated transcription factor activity 6/1822 60/18639 0.1 1.02299670691548 0.539967680308618 0.999999999999945 GO:0015101 organic cation transmembrane transporter activity 8/1822 81/18639 0.0987654320987654 1.01036711794121 0.542483135266998 0.999999999999945 GO:0033192 calmodulin-dependent protein phosphatase activity 8/1822 81/18639 0.0987654320987654 1.01036711794121 0.542483135266998 0.999999999999945 GO:0140791 histone H2AXS140 phosphatase activity 8/1822 81/18639 0.0987654320987654 1.01036711794121 0.542483135266998 0.999999999999945 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 8/1822 81/18639 0.0987654320987654 1.01036711794121 0.542483135266998 0.999999999999945 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 8/1822 81/18639 0.0987654320987654 1.01036711794121 0.542483135266998 0.999999999999945 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 8/1822 81/18639 0.0987654320987654 1.01036711794121 0.542483135266998 0.999999999999945 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 8/1822 81/18639 0.0987654320987654 1.01036711794121 0.542483135266998 0.999999999999945 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 8/1822 81/18639 0.0987654320987654 1.01036711794121 0.542483135266998 0.999999999999945 GO:1990439 MAP kinase serine/threonine phosphatase activity 8/1822 81/18639 0.0987654320987654 1.01036711794121 0.542483135266998 0.999999999999945 GO:0004674 protein serine/threonine kinase activity 42/1822 433/18639 0.0969976905311778 0.992283179918015 0.54563589538196 0.999999999999945 GO:0140299 molecular sensor activity 7/1822 71/18639 0.0985915492957746 1.00858830259272 0.548934106961297 0.999999999999945 GO:0004181 metallocarboxypeptidase activity 3/1822 29/18639 0.103448275862069 1.0582724554298 0.549104326109661 0.999999999999945 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 3/1822 29/18639 0.103448275862069 1.0582724554298 0.549104326109661 0.999999999999945 GO:0099604 ligand-gated calcium channel activity 3/1822 29/18639 0.103448275862069 1.0582724554298 0.549104326109661 0.999999999999945 GO:0016836 hydro-lyase activity 6/1822 61/18639 0.0983606557377049 1.00622626909719 0.556628961116877 0.999999999999945 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 8/1822 82/18639 0.0975609756097561 0.998045567722417 0.556848321431148 0.999999999999945 GO:0033549 MAP kinase phosphatase activity 8/1822 82/18639 0.0975609756097561 0.998045567722417 0.556848321431148 0.999999999999945 GO:0004722 protein serine/threonine phosphatase activity 10/1822 103/18639 0.0970873786407767 0.993200686325706 0.557837780246162 0.999999999999945 GO:0051213 dioxygenase activity 9/1822 93/18639 0.0967741935483871 0.98999681314401 0.563980557231642 0.999999999999945 GO:0005346 purine ribonucleotide transmembrane transporter activity 2/1822 19/18639 0.105263157894737 1.0768386388584 0.566904444019505 0.999999999999945 GO:0015245 fatty acid transmembrane transporter activity 2/1822 19/18639 0.105263157894737 1.0768386388584 0.566904444019505 0.999999999999945 GO:0022840 leak channel activity 2/1822 19/18639 0.105263157894737 1.0768386388584 0.566904444019505 0.999999999999945 GO:0022842 narrow pore channel activity 2/1822 19/18639 0.105263157894737 1.0768386388584 0.566904444019505 0.999999999999945 GO:0042577 lipid phosphatase activity 2/1822 19/18639 0.105263157894737 1.0768386388584 0.566904444019505 0.999999999999945 GO:0046527 glucosyltransferase activity 2/1822 19/18639 0.105263157894737 1.0768386388584 0.566904444019505 0.999999999999945 GO:0097001 ceramide binding 2/1822 19/18639 0.105263157894737 1.0768386388584 0.566904444019505 0.999999999999945 GO:0099589 serotonin receptor activity 2/1822 19/18639 0.105263157894737 1.0768386388584 0.566904444019505 0.999999999999945 GO:0140036 ubiquitin-modified protein reader activity 2/1822 19/18639 0.105263157894737 1.0768386388584 0.566904444019505 0.999999999999945 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 8/1822 83/18639 0.0963855421686747 0.986020922328171 0.571018957905867 0.999999999999945 GO:0005254 chloride channel activity 8/1822 83/18639 0.0963855421686747 0.986020922328171 0.571018957905867 0.999999999999945 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 3/1822 30/18639 0.1 1.02299670691548 0.572712336311636 0.999999999999945 GO:0008187 poly-pyrimidine tract binding 3/1822 30/18639 0.1 1.02299670691548 0.572712336311636 0.999999999999945 GO:0022839 monoatomic ion-gated channel activity 3/1822 30/18639 0.1 1.02299670691548 0.572712336311636 0.999999999999945 GO:0033612 receptor serine/threonine kinase binding 3/1822 30/18639 0.1 1.02299670691548 0.572712336311636 0.999999999999945 GO:0015179 L-amino acid transmembrane transporter activity 6/1822 62/18639 0.0967741935483871 0.98999681314401 0.573003801292074 0.999999999999945 GO:0016779 nucleotidyltransferase activity 13/1822 136/18639 0.0955882352941176 0.977864499257442 0.576550268229608 0.999999999999945 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 4/1822 41/18639 0.0975609756097561 0.998045567722417 0.578417150261926 0.999999999999945 GO:0140318 protein transporter activity 4/1822 41/18639 0.0975609756097561 0.998045567722417 0.578417150261926 0.999999999999945 GO:0005080 protein kinase C binding 5/1822 52/18639 0.0961538461538462 0.983650679726421 0.583878836292338 0.999999999999945 GO:0017018 myosin phosphatase activity 8/1822 84/18639 0.0952380952380952 0.97428257801474 0.584981896589595 0.999999999999945 GO:0046873 metal ion transmembrane transporter activity 43/1822 450/18639 0.0955555555555556 0.977530186608123 0.586921957498635 0.999999999999945 GO:0022824 transmitter-gated monoatomic ion channel activity 6/1822 63/18639 0.0952380952380952 0.97428257801474 0.589073889056649 0.999999999999945 GO:0022835 transmitter-gated channel activity 6/1822 63/18639 0.0952380952380952 0.97428257801474 0.589073889056649 0.999999999999945 GO:0004519 endonuclease activity 12/1822 127/18639 0.094488188976378 0.96661106165242 0.593486909719711 0.999999999999945 GO:0004497 monooxygenase activity 10/1822 106/18639 0.0943396226415094 0.96509123293913 0.595365808659123 0.999999999999945 GO:0000339 RNA cap binding 2/1822 20/18639 0.1 1.02299670691548 0.595421798669471 0.999999999999945 GO:0010851 cyclase regulator activity 2/1822 20/18639 0.1 1.02299670691548 0.595421798669471 0.999999999999945 GO:0043024 ribosomal small subunit binding 2/1822 20/18639 0.1 1.02299670691548 0.595421798669471 0.999999999999945 GO:0052745 inositol phosphate phosphatase activity 2/1822 20/18639 0.1 1.02299670691548 0.595421798669471 0.999999999999945 GO:0140939 histone H4 methyltransferase activity 2/1822 20/18639 0.1 1.02299670691548 0.595421798669471 0.999999999999945 GO:0047499 calcium-independent phospholipase A2 activity 3/1822 31/18639 0.0967741935483871 0.98999681314401 0.595534155897273 0.999999999999945 GO:0072349 modified amino acid transmembrane transporter activity 3/1822 31/18639 0.0967741935483871 0.98999681314401 0.595534155897273 0.999999999999945 GO:0042056 chemoattractant activity 4/1822 42/18639 0.0952380952380952 0.97428257801474 0.597966042715634 0.999999999999945 GO:0004864 protein phosphatase inhibitor activity 5/1822 53/18639 0.0943396226415094 0.96509123293913 0.601232685568272 0.999999999999945 GO:0008146 sulfotransferase activity 5/1822 53/18639 0.0943396226415094 0.96509123293913 0.601232685568272 0.999999999999945 GO:0019888 protein phosphatase regulator activity 10/1822 107/18639 0.0934579439252336 0.956071688706054 0.607539713216053 0.999999999999945 GO:0044183 protein folding chaperone 7/1822 75/18639 0.0933333333333333 0.954796926454446 0.60852391512309 0.999999999999945 GO:0019842 vitamin binding 14/1822 150/18639 0.0933333333333333 0.954796926454446 0.613123815259588 0.999999999999945 GO:0015291 secondary active transmembrane transporter activity 27/1822 287/18639 0.0940766550522648 0.962401083160902 0.613157781669531 0.999999999999945 GO:0031369 translation initiation factor binding 3/1822 32/18639 0.09375 0.95905941273326 0.61754512151777 0.999999999999945 GO:0043425 bHLH transcription factor binding 3/1822 32/18639 0.09375 0.95905941273326 0.61754512151777 0.999999999999945 GO:0070717 poly-purine tract binding 3/1822 32/18639 0.09375 0.95905941273326 0.61754512151777 0.999999999999945 GO:0140463 chromatin-protein adaptor activity 5/1822 54/18639 0.0925925925925926 0.947219173069887 0.61816813953179 0.999999999999945 GO:0001846 opsonin binding 2/1822 21/18639 0.0952380952380952 0.97428257801474 0.622505792708654 0.999999999999945 GO:0009975 cyclase activity 2/1822 21/18639 0.0952380952380952 0.97428257801474 0.622505792708654 0.999999999999945 GO:0010314 phosphatidylinositol-5-phosphate binding 2/1822 21/18639 0.0952380952380952 0.97428257801474 0.622505792708654 0.999999999999945 GO:0015125 bile acid transmembrane transporter activity 2/1822 21/18639 0.0952380952380952 0.97428257801474 0.622505792708654 0.999999999999945 GO:0036122 BMP binding 2/1822 21/18639 0.0952380952380952 0.97428257801474 0.622505792708654 0.999999999999945 GO:0051428 peptide hormone receptor binding 2/1822 21/18639 0.0952380952380952 0.97428257801474 0.622505792708654 0.999999999999945 GO:0140312 cargo adaptor activity 2/1822 21/18639 0.0952380952380952 0.97428257801474 0.622505792708654 0.999999999999945 GO:1904047 S-adenosyl-L-methionine binding 2/1822 21/18639 0.0952380952380952 0.97428257801474 0.622505792708654 0.999999999999945 GO:0042626 ATPase-coupled transmembrane transporter activity 9/1822 98/18639 0.0918367346938776 0.939486771657071 0.628391541268674 0.999999999999945 GO:0005244 voltage-gated monoatomic ion channel activity 16/1822 173/18639 0.092485549132948 0.946124122002754 0.630361314204971 0.999999999999945 GO:0046906 tetrapyrrole binding 14/1822 152/18639 0.0921052631578947 0.942233809001098 0.633251086145344 0.999999999999945 GO:0043014 alpha-tubulin binding 4/1822 44/18639 0.0909090909090909 0.929997006286798 0.635383585695766 0.999999999999945 GO:0005262 calcium channel activity 12/1822 131/18639 0.0916030534351145 0.937096220075247 0.637261030469377 0.999999999999945 GO:0031072 heat shock protein binding 12/1822 131/18639 0.0916030534351145 0.937096220075247 0.637261030469377 0.999999999999945 GO:0020037 heme binding 13/1822 142/18639 0.0915492957746479 0.936546280978958 0.640202896385973 0.999999999999945 GO:0000182 rDNA binding 1/1822 10/18639 0.1 1.02299670691548 0.642607430505454 0.999999999999945 GO:0001094 TFIID-class transcription factor complex binding 1/1822 10/18639 0.1 1.02299670691548 0.642607430505454 0.999999999999945 GO:0003796 lysozyme activity 1/1822 10/18639 0.1 1.02299670691548 0.642607430505454 0.999999999999945 GO:0004382 GDP phosphatase activity 1/1822 10/18639 0.1 1.02299670691548 0.642607430505454 0.999999999999945 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 1/1822 10/18639 0.1 1.02299670691548 0.642607430505454 0.999999999999945 GO:0004445 inositol-polyphosphate 5-phosphatase activity 1/1822 10/18639 0.1 1.02299670691548 0.642607430505454 0.999999999999945 GO:0004983 neuropeptide Y receptor activity 1/1822 10/18639 0.1 1.02299670691548 0.642607430505454 0.999999999999945 GO:0005131 growth hormone receptor binding 1/1822 10/18639 0.1 1.02299670691548 0.642607430505454 0.999999999999945 GO:0005337 nucleoside transmembrane transporter activity 1/1822 10/18639 0.1 1.02299670691548 0.642607430505454 0.999999999999945 GO:0005381 iron ion transmembrane transporter activity 1/1822 10/18639 0.1 1.02299670691548 0.642607430505454 0.999999999999945 GO:0008190 eukaryotic initiation factor 4E binding 1/1822 10/18639 0.1 1.02299670691548 0.642607430505454 0.999999999999945 GO:0008401 retinoic acid 4-hydroxylase activity 1/1822 10/18639 0.1 1.02299670691548 0.642607430505454 0.999999999999945 GO:0016175 superoxide-generating NAD(P)H oxidase activity 1/1822 10/18639 0.1 1.02299670691548 0.642607430505454 0.999999999999945 GO:0016427 tRNA (cytidine) methyltransferase activity 1/1822 10/18639 0.1 1.02299670691548 0.642607430505454 0.999999999999945 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1/1822 10/18639 0.1 1.02299670691548 0.642607430505454 0.999999999999945 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 1/1822 10/18639 0.1 1.02299670691548 0.642607430505454 0.999999999999945 GO:0016868 intramolecular phosphotransferase activity 1/1822 10/18639 0.1 1.02299670691548 0.642607430505454 0.999999999999945 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 1/1822 10/18639 0.1 1.02299670691548 0.642607430505454 0.999999999999945 GO:0019531 oxalate transmembrane transporter activity 1/1822 10/18639 0.1 1.02299670691548 0.642607430505454 0.999999999999945 GO:0031419 cobalamin binding 1/1822 10/18639 0.1 1.02299670691548 0.642607430505454 0.999999999999945 GO:0031434 mitogen-activated protein kinase kinase binding 1/1822 10/18639 0.1 1.02299670691548 0.642607430505454 0.999999999999945 GO:0031957 very long-chain fatty acid-CoA ligase activity 1/1822 10/18639 0.1 1.02299670691548 0.642607430505454 0.999999999999945 GO:0032052 bile acid binding 1/1822 10/18639 0.1 1.02299670691548 0.642607430505454 0.999999999999945 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 1/1822 10/18639 0.1 1.02299670691548 0.642607430505454 0.999999999999945 GO:0035256 G protein-coupled glutamate receptor binding 1/1822 10/18639 0.1 1.02299670691548 0.642607430505454 0.999999999999945 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 1/1822 10/18639 0.1 1.02299670691548 0.642607430505454 0.999999999999945 GO:0043422 protein kinase B binding 1/1822 10/18639 0.1 1.02299670691548 0.642607430505454 0.999999999999945 GO:0045322 unmethylated CpG binding 1/1822 10/18639 0.1 1.02299670691548 0.642607430505454 0.999999999999945 GO:0050815 phosphoserine residue binding 1/1822 10/18639 0.1 1.02299670691548 0.642607430505454 0.999999999999945 GO:0051378 serotonin binding 1/1822 10/18639 0.1 1.02299670691548 0.642607430505454 0.999999999999945 GO:0070513 death domain binding 1/1822 10/18639 0.1 1.02299670691548 0.642607430505454 0.999999999999945 GO:0070739 protein-glutamic acid ligase activity 1/1822 10/18639 0.1 1.02299670691548 0.642607430505454 0.999999999999945 GO:0070740 tubulin-glutamic acid ligase activity 1/1822 10/18639 0.1 1.02299670691548 0.642607430505454 0.999999999999945 GO:0071723 lipopeptide binding 1/1822 10/18639 0.1 1.02299670691548 0.642607430505454 0.999999999999945 GO:0140940 histone H2A methyltransferase activity 1/1822 10/18639 0.1 1.02299670691548 0.642607430505454 0.999999999999945 GO:1990259 histone H2AQ104 methyltransferase activity 1/1822 10/18639 0.1 1.02299670691548 0.642607430505454 0.999999999999945 GO:1990757 ubiquitin ligase activator activity 1/1822 10/18639 0.1 1.02299670691548 0.642607430505454 0.999999999999945 GO:0051082 unfolded protein binding 11/1822 121/18639 0.0909090909090909 0.929997006286798 0.645345367142541 0.999999999999945 GO:0050321 tau-protein kinase activity 2/1822 22/18639 0.0909090909090909 0.929997006286798 0.648164014776745 0.999999999999945 GO:0140035 ubiquitin-like protein reader activity 2/1822 22/18639 0.0909090909090909 0.929997006286798 0.648164014776745 0.999999999999945 GO:0140517 protein-RNA adaptor activity 2/1822 22/18639 0.0909090909090909 0.929997006286798 0.648164014776745 0.999999999999945 GO:0022832 voltage-gated channel activity 16/1822 175/18639 0.0914285714285714 0.935311274894151 0.648831793613394 0.999999999999945 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 6/1822 67/18639 0.0895522388059701 0.916116453954159 0.650008079658054 0.999999999999945 GO:0042054 histone methyltransferase activity 6/1822 67/18639 0.0895522388059701 0.916116453954159 0.650008079658054 0.999999999999945 GO:0019212 phosphatase inhibitor activity 5/1822 56/18639 0.0892857142857143 0.913389916888819 0.650726635311178 0.999999999999945 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 3/1822 34/18639 0.0882352941176471 0.902644153160716 0.659073502150308 0.999999999999945 GO:0030332 cyclin binding 3/1822 34/18639 0.0882352941176471 0.902644153160716 0.659073502150308 0.999999999999945 GO:0051427 hormone receptor binding 3/1822 34/18639 0.0882352941176471 0.902644153160716 0.659073502150308 0.999999999999945 GO:0031267 small GTPase binding 26/1822 283/18639 0.0918727915194346 0.939855631795138 0.660855270461766 0.999999999999945 GO:0016835 carbon-oxygen lyase activity 7/1822 79/18639 0.0886075949367089 0.906452778279537 0.66365661774801 0.999999999999945 GO:0015932 nucleobase-containing compound transmembrane transporter activity 5/1822 57/18639 0.087719298245614 0.897365532381998 0.666327414761013 0.999999999999945 GO:0046943 carboxylic acid transmembrane transporter activity 17/1822 188/18639 0.0904255319148936 0.925050213700166 0.669037550422048 0.999999999999945 GO:0030276 clathrin binding 4/1822 46/18639 0.0869565217391304 0.889562353839546 0.670465061669056 0.999999999999945 GO:0030291 protein serine/threonine kinase inhibitor activity 4/1822 46/18639 0.0869565217391304 0.889562353839546 0.670465061669056 0.999999999999945 GO:0000295 adenine nucleotide transmembrane transporter activity 2/1822 23/18639 0.0869565217391304 0.889562353839546 0.672416261017917 0.999999999999945 GO:0005212 structural constituent of eye lens 2/1822 23/18639 0.0869565217391304 0.889562353839546 0.672416261017917 0.999999999999945 GO:0008171 O-methyltransferase activity 2/1822 23/18639 0.0869565217391304 0.889562353839546 0.672416261017917 0.999999999999945 GO:0016917 GABA receptor activity 2/1822 23/18639 0.0869565217391304 0.889562353839546 0.672416261017917 0.999999999999945 GO:0070577 lysine-acetylated histone binding 2/1822 23/18639 0.0869565217391304 0.889562353839546 0.672416261017917 0.999999999999945 GO:0015171 amino acid transmembrane transporter activity 9/1822 102/18639 0.0882352941176471 0.902644153160716 0.676038365301211 0.999999999999945 GO:0000099 sulfur amino acid transmembrane transporter activity 1/1822 11/18639 0.0909090909090909 0.929997006286798 0.677562031483448 0.999999999999945 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 1/1822 11/18639 0.0909090909090909 0.929997006286798 0.677562031483448 0.999999999999945 GO:0003953 NAD+ nucleosidase activity 1/1822 11/18639 0.0909090909090909 0.929997006286798 0.677562031483448 0.999999999999945 GO:0004016 adenylate cyclase activity 1/1822 11/18639 0.0909090909090909 0.929997006286798 0.677562031483448 0.999999999999945 GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity 1/1822 11/18639 0.0909090909090909 0.929997006286798 0.677562031483448 0.999999999999945 GO:0005221 intracellularly cyclic nucleotide-activated monoatomic cation channel activity 1/1822 11/18639 0.0909090909090909 0.929997006286798 0.677562031483448 0.999999999999945 GO:0005225 volume-sensitive anion channel activity 1/1822 11/18639 0.0909090909090909 0.929997006286798 0.677562031483448 0.999999999999945 GO:0005536 D-glucose binding 1/1822 11/18639 0.0909090909090909 0.929997006286798 0.677562031483448 0.999999999999945 GO:0008046 axon guidance receptor activity 1/1822 11/18639 0.0909090909090909 0.929997006286798 0.677562031483448 0.999999999999945 GO:0010854 adenylate cyclase regulator activity 1/1822 11/18639 0.0909090909090909 0.929997006286798 0.677562031483448 0.999999999999945 GO:0016176 superoxide-generating NADPH oxidase activator activity 1/1822 11/18639 0.0909090909090909 0.929997006286798 0.677562031483448 0.999999999999945 GO:0016594 glycine binding 1/1822 11/18639 0.0909090909090909 0.929997006286798 0.677562031483448 0.999999999999945 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 1/1822 11/18639 0.0909090909090909 0.929997006286798 0.677562031483448 0.999999999999945 GO:0019215 intermediate filament binding 1/1822 11/18639 0.0909090909090909 0.929997006286798 0.677562031483448 0.999999999999945 GO:0019864 IgG binding 1/1822 11/18639 0.0909090909090909 0.929997006286798 0.677562031483448 0.999999999999945 GO:0031731 CCR6 chemokine receptor binding 1/1822 11/18639 0.0909090909090909 0.929997006286798 0.677562031483448 0.999999999999945 GO:0032050 clathrin heavy chain binding 1/1822 11/18639 0.0909090909090909 0.929997006286798 0.677562031483448 0.999999999999945 GO:0032404 mismatch repair complex binding 1/1822 11/18639 0.0909090909090909 0.929997006286798 0.677562031483448 0.999999999999945 GO:0034056 estrogen response element binding 1/1822 11/18639 0.0909090909090909 0.929997006286798 0.677562031483448 0.999999999999945 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 1/1822 11/18639 0.0909090909090909 0.929997006286798 0.677562031483448 0.999999999999945 GO:0035252 UDP-xylosyltransferase activity 1/1822 11/18639 0.0909090909090909 0.929997006286798 0.677562031483448 0.999999999999945 GO:0042285 xylosyltransferase activity 1/1822 11/18639 0.0909090909090909 0.929997006286798 0.677562031483448 0.999999999999945 GO:0043522 leucine zipper domain binding 1/1822 11/18639 0.0909090909090909 0.929997006286798 0.677562031483448 0.999999999999945 GO:0043855 cyclic nucleotide-activated monoatomic ion channel activity 1/1822 11/18639 0.0909090909090909 0.929997006286798 0.677562031483448 0.999999999999945 GO:0045294 alpha-catenin binding 1/1822 11/18639 0.0909090909090909 0.929997006286798 0.677562031483448 0.999999999999945 GO:0047676 arachidonate-CoA ligase activity 1/1822 11/18639 0.0909090909090909 0.929997006286798 0.677562031483448 0.999999999999945 GO:0048101 calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity 1/1822 11/18639 0.0909090909090909 0.929997006286798 0.677562031483448 0.999999999999945 GO:0050786 RAGE receptor binding 1/1822 11/18639 0.0909090909090909 0.929997006286798 0.677562031483448 0.999999999999945 GO:0070697 activin receptor binding 1/1822 11/18639 0.0909090909090909 0.929997006286798 0.677562031483448 0.999999999999945 GO:0070990 snRNP binding 1/1822 11/18639 0.0909090909090909 0.929997006286798 0.677562031483448 0.999999999999945 GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 1/1822 11/18639 0.0909090909090909 0.929997006286798 0.677562031483448 0.999999999999945 GO:0099528 G protein-coupled neurotransmitter receptor activity 1/1822 11/18639 0.0909090909090909 0.929997006286798 0.677562031483448 0.999999999999945 GO:0005342 organic acid transmembrane transporter activity 17/1822 189/18639 0.0899470899470899 0.920155768125033 0.67756282015599 0.999999999999945 GO:0016279 protein-lysine N-methyltransferase activity 6/1822 69/18639 0.0869565217391304 0.889562353839546 0.678309535125068 0.999999999999945 GO:0015297 antiporter activity 12/1822 135/18639 0.0888888888888889 0.909330406147091 0.678456079462286 0.999999999999945 GO:0004623 phospholipase A2 activity 3/1822 35/18639 0.0857142857142857 0.876854320213266 0.678576852619281 0.999999999999945 GO:0061980 regulatory RNA binding 5/1822 58/18639 0.0862068965517241 0.88189371285817 0.681464992459617 0.999999999999945 GO:0005253 monoatomic anion channel activity 9/1822 103/18639 0.087378640776699 0.893880617693136 0.687355442593716 0.999999999999945 GO:0015085 calcium ion transmembrane transporter activity 13/1822 147/18639 0.0884353741496599 0.904690965299402 0.689213798369996 0.999999999999945 GO:0016278 lysine N-methyltransferase activity 6/1822 70/18639 0.0857142857142857 0.876854320213266 0.691891263458576 0.999999999999945 GO:0016782 transferase activity, transferring sulphur-containing groups 6/1822 70/18639 0.0857142857142857 0.876854320213266 0.691891263458576 0.999999999999945 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 2/1822 24/18639 0.0833333333333333 0.852497255762898 0.695292078352308 0.999999999999945 GO:0030215 semaphorin receptor binding 2/1822 24/18639 0.0833333333333333 0.852497255762898 0.695292078352308 0.999999999999945 GO:0140033 acetylation-dependent protein binding 2/1822 24/18639 0.0833333333333333 0.852497255762898 0.695292078352308 0.999999999999945 GO:0070063 RNA polymerase binding 5/1822 59/18639 0.0847457627118644 0.866946361792778 0.696133947851411 0.999999999999945 GO:0016409 palmitoyltransferase activity 3/1822 36/18639 0.0833333333333333 0.852497255762898 0.697239718892353 0.999999999999945 GO:0045505 dynein intermediate chain binding 3/1822 36/18639 0.0833333333333333 0.852497255762898 0.697239718892353 0.999999999999945 GO:0001216 DNA-binding transcription activator activity 45/1822 491/18639 0.0916496945010183 0.937573356643513 0.699982842253684 0.999999999999945 GO:0000340 RNA 7-methylguanosine cap binding 1/1822 12/18639 0.0833333333333333 0.852497255762898 0.709099608176446 0.999999999999945 GO:0004000 adenosine deaminase activity 1/1822 12/18639 0.0833333333333333 0.852497255762898 0.709099608176446 0.999999999999945 GO:0004032 aldose reductase (NADPH) activity 1/1822 12/18639 0.0833333333333333 0.852497255762898 0.709099608176446 0.999999999999945 GO:0004126 cytidine deaminase activity 1/1822 12/18639 0.0833333333333333 0.852497255762898 0.709099608176446 0.999999999999945 GO:0004300 enoyl-CoA hydratase activity 1/1822 12/18639 0.0833333333333333 0.852497255762898 0.709099608176446 0.999999999999945 GO:0004859 phospholipase inhibitor activity 1/1822 12/18639 0.0833333333333333 0.852497255762898 0.709099608176446 0.999999999999945 GO:0005078 MAP-kinase scaffold activity 1/1822 12/18639 0.0833333333333333 0.852497255762898 0.709099608176446 0.999999999999945 GO:0008179 adenylate cyclase binding 1/1822 12/18639 0.0833333333333333 0.852497255762898 0.709099608176446 0.999999999999945 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 1/1822 12/18639 0.0833333333333333 0.852497255762898 0.709099608176446 0.999999999999945 GO:0010853 cyclase activator activity 1/1822 12/18639 0.0833333333333333 0.852497255762898 0.709099608176446 0.999999999999945 GO:0015132 prostaglandin transmembrane transporter activity 1/1822 12/18639 0.0833333333333333 0.852497255762898 0.709099608176446 0.999999999999945 GO:0016273 arginine N-methyltransferase activity 1/1822 12/18639 0.0833333333333333 0.852497255762898 0.709099608176446 0.999999999999945 GO:0016274 protein-arginine N-methyltransferase activity 1/1822 12/18639 0.0833333333333333 0.852497255762898 0.709099608176446 0.999999999999945 GO:0016423 tRNA (guanine) methyltransferase activity 1/1822 12/18639 0.0833333333333333 0.852497255762898 0.709099608176446 0.999999999999945 GO:0016801 hydrolase activity, acting on ether bonds 1/1822 12/18639 0.0833333333333333 0.852497255762898 0.709099608176446 0.999999999999945 GO:0016803 ether hydrolase activity 1/1822 12/18639 0.0833333333333333 0.852497255762898 0.709099608176446 0.999999999999945 GO:0016840 carbon-nitrogen lyase activity 1/1822 12/18639 0.0833333333333333 0.852497255762898 0.709099608176446 0.999999999999945 GO:0035014 phosphatidylinositol 3-kinase regulator activity 1/1822 12/18639 0.0833333333333333 0.852497255762898 0.709099608176446 0.999999999999945 GO:0036009 protein-glutamine N-methyltransferase activity 1/1822 12/18639 0.0833333333333333 0.852497255762898 0.709099608176446 0.999999999999945 GO:0070410 co-SMAD binding 1/1822 12/18639 0.0833333333333333 0.852497255762898 0.709099608176446 0.999999999999945 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 1/1822 12/18639 0.0833333333333333 0.852497255762898 0.709099608176446 0.999999999999945 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 1/1822 12/18639 0.0833333333333333 0.852497255762898 0.709099608176446 0.999999999999945 GO:1990247 N6-methyladenosine-containing RNA reader activity 1/1822 12/18639 0.0833333333333333 0.852497255762898 0.709099608176446 0.999999999999945 GO:1990459 transferrin receptor binding 1/1822 12/18639 0.0833333333333333 0.852497255762898 0.709099608176446 0.999999999999945 GO:1990817 poly(A) RNA polymerase activity 1/1822 12/18639 0.0833333333333333 0.852497255762898 0.709099608176446 0.999999999999945 GO:0035403 histone H3T6 kinase activity 22/1822 247/18639 0.0890688259109312 0.911171155957105 0.709197267302023 0.999999999999945 GO:0003714 transcription corepressor activity 18/1822 204/18639 0.0882352941176471 0.902644153160716 0.711431988622337 0.999999999999945 GO:0001848 complement binding 2/1822 25/18639 0.08 0.818397365532382 0.716828670981316 0.999999999999945 GO:0003707 nuclear steroid receptor activity 2/1822 25/18639 0.08 0.818397365532382 0.716828670981316 0.999999999999945 GO:0004709 MAP kinase kinase kinase activity 2/1822 25/18639 0.08 0.818397365532382 0.716828670981316 0.999999999999945 GO:0015662 P-type ion transporter activity 2/1822 25/18639 0.08 0.818397365532382 0.716828670981316 0.999999999999945 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 2/1822 25/18639 0.08 0.818397365532382 0.716828670981316 0.999999999999945 GO:0017025 TBP-class protein binding 2/1822 25/18639 0.08 0.818397365532382 0.716828670981316 0.999999999999945 GO:0019706 protein-cysteine S-palmitoyltransferase activity 2/1822 25/18639 0.08 0.818397365532382 0.716828670981316 0.999999999999945 GO:0019707 protein-cysteine S-acyltransferase activity 2/1822 25/18639 0.08 0.818397365532382 0.716828670981316 0.999999999999945 GO:0140358 P-type transmembrane transporter activity 2/1822 25/18639 0.08 0.818397365532382 0.716828670981316 0.999999999999945 GO:0043539 protein serine/threonine kinase activator activity 6/1822 73/18639 0.0821917808219178 0.840819211163406 0.730311665547594 0.999999999999945 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 20/1822 229/18639 0.0873362445414847 0.893446905603037 0.735193894373713 0.999999999999945 GO:0008066 glutamate receptor activity 2/1822 26/18639 0.0769230769230769 0.786920543781137 0.737069122646928 0.999999999999945 GO:0008157 protein phosphatase 1 binding 2/1822 26/18639 0.0769230769230769 0.786920543781137 0.737069122646928 0.999999999999945 GO:0015216 purine nucleotide transmembrane transporter activity 2/1822 26/18639 0.0769230769230769 0.786920543781137 0.737069122646928 0.999999999999945 GO:0052742 phosphatidylinositol kinase activity 2/1822 26/18639 0.0769230769230769 0.786920543781137 0.737069122646928 0.999999999999945 GO:0120014 phospholipid transfer activity 2/1822 26/18639 0.0769230769230769 0.786920543781137 0.737069122646928 0.999999999999945 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 1/1822 13/18639 0.0769230769230769 0.786920543781137 0.737554029924581 0.999999999999945 GO:0004465 lipoprotein lipase activity 1/1822 13/18639 0.0769230769230769 0.786920543781137 0.737554029924581 0.999999999999945 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 1/1822 13/18639 0.0769230769230769 0.786920543781137 0.737554029924581 0.999999999999945 GO:0005172 vascular endothelial growth factor receptor binding 1/1822 13/18639 0.0769230769230769 0.786920543781137 0.737554029924581 0.999999999999945 GO:0005338 nucleotide-sugar transmembrane transporter activity 1/1822 13/18639 0.0769230769230769 0.786920543781137 0.737554029924581 0.999999999999945 GO:0005542 folic acid binding 1/1822 13/18639 0.0769230769230769 0.786920543781137 0.737554029924581 0.999999999999945 GO:0008035 high-density lipoprotein particle binding 1/1822 13/18639 0.0769230769230769 0.786920543781137 0.737554029924581 0.999999999999945 GO:0008417 fucosyltransferase activity 1/1822 13/18639 0.0769230769230769 0.786920543781137 0.737554029924581 0.999999999999945 GO:0030955 potassium ion binding 1/1822 13/18639 0.0769230769230769 0.786920543781137 0.737554029924581 0.999999999999945 GO:0032396 inhibitory MHC class I receptor activity 1/1822 13/18639 0.0769230769230769 0.786920543781137 0.737554029924581 0.999999999999945 GO:0045159 myosin II binding 1/1822 13/18639 0.0769230769230769 0.786920543781137 0.737554029924581 0.999999999999945 GO:0046974 histone H3K9 methyltransferase activity 1/1822 13/18639 0.0769230769230769 0.786920543781137 0.737554029924581 0.999999999999945 GO:0046975 histone H3K36 methyltransferase activity 1/1822 13/18639 0.0769230769230769 0.786920543781137 0.737554029924581 0.999999999999945 GO:0071714 icosanoid transmembrane transporter activity 1/1822 13/18639 0.0769230769230769 0.786920543781137 0.737554029924581 0.999999999999945 GO:0071837 HMG box domain binding 1/1822 13/18639 0.0769230769230769 0.786920543781137 0.737554029924581 0.999999999999945 GO:0097157 pre-mRNA intronic binding 1/1822 13/18639 0.0769230769230769 0.786920543781137 0.737554029924581 0.999999999999945 GO:0030594 neurotransmitter receptor activity 8/1822 97/18639 0.0824742268041237 0.843708624260188 0.743448210089361 0.999999999999945 GO:0016597 amino acid binding 4/1822 51/18639 0.0784313725490196 0.80235035836508 0.747654412068819 0.999999999999945 GO:0050660 flavin adenine dinucleotide binding 7/1822 86/18639 0.0813953488372093 0.832671738187017 0.747897444297992 0.999999999999945 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 3/1822 39/18639 0.0769230769230769 0.786920543781137 0.748266192714703 0.999999999999945 GO:0008170 N-methyltransferase activity 8/1822 98/18639 0.0816326530612245 0.835099352584063 0.753675469540089 0.999999999999945 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 2/1822 27/18639 0.0740740740740741 0.757775338455909 0.756060892969469 0.999999999999945 GO:0035255 ionotropic glutamate receptor binding 2/1822 27/18639 0.0740740740740741 0.757775338455909 0.756060892969469 0.999999999999945 GO:0016829 lyase activity 17/1822 200/18639 0.085 0.869547200878156 0.762829572037567 0.999999999999945 GO:0008195 phosphatidate phosphatase activity 1/1822 14/18639 0.0714285714285714 0.730711933511055 0.763226560659973 0.999999999999945 GO:0008331 high voltage-gated calcium channel activity 1/1822 14/18639 0.0714285714285714 0.730711933511055 0.763226560659973 0.999999999999945 GO:0008392 arachidonate epoxygenase activity 1/1822 14/18639 0.0714285714285714 0.730711933511055 0.763226560659973 0.999999999999945 GO:0008559 ABC-type xenobiotic transporter activity 1/1822 14/18639 0.0714285714285714 0.730711933511055 0.763226560659973 0.999999999999945 GO:0015926 glucosidase activity 1/1822 14/18639 0.0714285714285714 0.730711933511055 0.763226560659973 0.999999999999945 GO:0019992 diacylglycerol binding 1/1822 14/18639 0.0714285714285714 0.730711933511055 0.763226560659973 0.999999999999945 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 1/1822 14/18639 0.0714285714285714 0.730711933511055 0.763226560659973 0.999999999999945 GO:0030983 mismatched DNA binding 1/1822 14/18639 0.0714285714285714 0.730711933511055 0.763226560659973 0.999999999999945 GO:0034236 protein kinase A catalytic subunit binding 1/1822 14/18639 0.0714285714285714 0.730711933511055 0.763226560659973 0.999999999999945 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 1/1822 14/18639 0.0714285714285714 0.730711933511055 0.763226560659973 0.999999999999945 GO:0042043 neurexin family protein binding 1/1822 14/18639 0.0714285714285714 0.730711933511055 0.763226560659973 0.999999999999945 GO:0042813 Wnt receptor activity 1/1822 14/18639 0.0714285714285714 0.730711933511055 0.763226560659973 0.999999999999945 GO:0043176 amine binding 1/1822 14/18639 0.0714285714285714 0.730711933511055 0.763226560659973 0.999999999999945 GO:0061665 SUMO ligase activity 1/1822 14/18639 0.0714285714285714 0.730711933511055 0.763226560659973 0.999999999999945 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 1/1822 14/18639 0.0714285714285714 0.730711933511055 0.763226560659973 0.999999999999945 GO:0071855 neuropeptide receptor binding 3/1822 40/18639 0.075 0.767247530186608 0.763665966556783 0.999999999999945 GO:0071949 FAD binding 3/1822 40/18639 0.075 0.767247530186608 0.763665966556783 0.999999999999945 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 43/1822 484/18639 0.0888429752066116 0.90886071068937 0.769596092455918 0.999999999999945 GO:0005242 inward rectifier potassium channel activity 2/1822 28/18639 0.0714285714285714 0.730711933511055 0.773854551312132 0.999999999999945 GO:0046966 nuclear thyroid hormone receptor binding 2/1822 28/18639 0.0714285714285714 0.730711933511055 0.773854551312132 0.999999999999945 GO:0051537 2 iron, 2 sulfur cluster binding 2/1822 28/18639 0.0714285714285714 0.730711933511055 0.773854551312132 0.999999999999945 GO:0016860 intramolecular oxidoreductase activity 4/1822 53/18639 0.0754716981132075 0.772072986351304 0.774369290280009 0.999999999999945 GO:0140296 general transcription initiation factor binding 4/1822 53/18639 0.0754716981132075 0.772072986351304 0.774369290280009 0.999999999999945 GO:0001530 lipopolysaccharide binding 3/1822 41/18639 0.0731707317073171 0.748534175791813 0.778290873106377 0.999999999999945 GO:0140828 metal cation:monoatomic cation antiporter activity 3/1822 41/18639 0.0731707317073171 0.748534175791813 0.778290873106377 0.999999999999945 GO:0000774 adenyl-nucleotide exchange factor activity 1/1822 15/18639 0.0666666666666667 0.681997804610318 0.786389041544673 0.999999999999945 GO:0004467 long-chain fatty acid-CoA ligase activity 1/1822 15/18639 0.0666666666666667 0.681997804610318 0.786389041544673 0.999999999999945 GO:0004865 protein serine/threonine phosphatase inhibitor activity 1/1822 15/18639 0.0666666666666667 0.681997804610318 0.786389041544673 0.999999999999945 GO:0010181 FMN binding 1/1822 15/18639 0.0666666666666667 0.681997804610318 0.786389041544673 0.999999999999945 GO:0016846 carbon-sulfur lyase activity 1/1822 15/18639 0.0666666666666667 0.681997804610318 0.786389041544673 0.999999999999945 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 1/1822 15/18639 0.0666666666666667 0.681997804610318 0.786389041544673 0.999999999999945 GO:0033130 acetylcholine receptor binding 1/1822 15/18639 0.0666666666666667 0.681997804610318 0.786389041544673 0.999999999999945 GO:0048531 beta-1,3-galactosyltransferase activity 1/1822 15/18639 0.0666666666666667 0.681997804610318 0.786389041544673 0.999999999999945 GO:0050700 CARD domain binding 1/1822 15/18639 0.0666666666666667 0.681997804610318 0.786389041544673 0.999999999999945 GO:0050780 dopamine receptor binding 1/1822 15/18639 0.0666666666666667 0.681997804610318 0.786389041544673 0.999999999999945 GO:0061578 K63-linked deubiquitinase activity 1/1822 15/18639 0.0666666666666667 0.681997804610318 0.786389041544673 0.999999999999945 GO:0120283 protein serine/threonine kinase binding 1/1822 15/18639 0.0666666666666667 0.681997804610318 0.786389041544673 0.999999999999945 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 4/1822 54/18639 0.0740740740740741 0.757775338455909 0.786865382339867 0.999999999999945 GO:0005416 amino acid:monoatomic cation symporter activity 2/1822 29/18639 0.0689655172413793 0.705514970286536 0.790502716141944 0.999999999999945 GO:0016417 S-acyltransferase activity 2/1822 29/18639 0.0689655172413793 0.705514970286536 0.790502716141944 0.999999999999945 GO:0048487 beta-tubulin binding 3/1822 42/18639 0.0714285714285714 0.730711933511055 0.792162013905665 0.999999999999945 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 7/1822 91/18639 0.0769230769230769 0.786920543781137 0.798143280887338 0.999999999999945 GO:0004712 protein serine/threonine/tyrosine kinase activity 3/1822 43/18639 0.0697674418604651 0.713718632731728 0.805302117166781 0.999999999999945 GO:0005245 voltage-gated calcium channel activity 3/1822 43/18639 0.0697674418604651 0.713718632731728 0.805302117166781 0.999999999999945 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 3/1822 43/18639 0.0697674418604651 0.713718632731728 0.805302117166781 0.999999999999945 GO:0015215 nucleotide transmembrane transporter activity 2/1822 30/18639 0.0666666666666667 0.681997804610318 0.806059171844109 0.999999999999945 GO:0031210 phosphatidylcholine binding 2/1822 30/18639 0.0666666666666667 0.681997804610318 0.806059171844109 0.999999999999945 GO:0048019 receptor antagonist activity 2/1822 30/18639 0.0666666666666667 0.681997804610318 0.806059171844109 0.999999999999945 GO:0051721 protein phosphatase 2A binding 2/1822 30/18639 0.0666666666666667 0.681997804610318 0.806059171844109 0.999999999999945 GO:0000062 fatty-acyl-CoA binding 1/1822 16/18639 0.0625 0.639372941822173 0.807286763103178 0.999999999999945 GO:0008391 arachidonate monooxygenase activity 1/1822 16/18639 0.0625 0.639372941822173 0.807286763103178 0.999999999999945 GO:0015385 sodium:proton antiporter activity 1/1822 16/18639 0.0625 0.639372941822173 0.807286763103178 0.999999999999945 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity 1/1822 16/18639 0.0625 0.639372941822173 0.807286763103178 0.999999999999945 GO:0030275 LRR domain binding 1/1822 16/18639 0.0625 0.639372941822173 0.807286763103178 0.999999999999945 GO:0043023 ribosomal large subunit binding 1/1822 16/18639 0.0625 0.639372941822173 0.807286763103178 0.999999999999945 GO:0055102 lipase inhibitor activity 1/1822 16/18639 0.0625 0.639372941822173 0.807286763103178 0.999999999999945 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 1/1822 16/18639 0.0625 0.639372941822173 0.807286763103178 0.999999999999945 GO:0097027 ubiquitin-protein transferase activator activity 1/1822 16/18639 0.0625 0.639372941822173 0.807286763103178 0.999999999999945 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 1/1822 16/18639 0.0625 0.639372941822173 0.807286763103178 0.999999999999945 GO:0001046 core promoter sequence-specific DNA binding 3/1822 44/18639 0.0681818181818182 0.697497754715098 0.817735180445149 0.999999999999945 GO:0004518 nuclease activity 17/1822 209/18639 0.0813397129186603 0.832102584572398 0.820350551762073 0.999999999999945 GO:0070273 phosphatidylinositol-4-phosphate binding 2/1822 31/18639 0.0645161290322581 0.65999787542934 0.820578138461132 0.999999999999945 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 20/1822 243/18639 0.0823045267489712 0.841972598284344 0.821607731323964 0.999999999999945 GO:0015081 sodium ion transmembrane transporter activity 13/1822 164/18639 0.0792682926829268 0.810912023774464 0.823611612495782 0.999999999999945 GO:0016410 N-acyltransferase activity 7/1822 94/18639 0.074468085106383 0.761806058341313 0.824417003227713 0.999999999999945 GO:0000149 SNARE binding 8/1822 106/18639 0.0754716981132075 0.772072986351304 0.825150894083562 0.999999999999945 GO:0015278 intracellularly gated calcium channel activity 1/1822 17/18639 0.0588235294117647 0.60176276877381 0.826141057128094 0.999999999999945 GO:0015347 sodium-independent organic anion transmembrane transporter activity 1/1822 17/18639 0.0588235294117647 0.60176276877381 0.826141057128094 0.999999999999945 GO:0030548 acetylcholine receptor regulator activity 1/1822 17/18639 0.0588235294117647 0.60176276877381 0.826141057128094 0.999999999999945 GO:0032977 membrane insertase activity 1/1822 17/18639 0.0588235294117647 0.60176276877381 0.826141057128094 0.999999999999945 GO:0045236 CXCR chemokine receptor binding 1/1822 17/18639 0.0588235294117647 0.60176276877381 0.826141057128094 0.999999999999945 GO:1901567 fatty acid derivative binding 1/1822 17/18639 0.0588235294117647 0.60176276877381 0.826141057128094 0.999999999999945 GO:1990226 histone methyltransferase binding 1/1822 17/18639 0.0588235294117647 0.60176276877381 0.826141057128094 0.999999999999945 GO:0016798 hydrolase activity, acting on glycosyl bonds 10/1822 130/18639 0.0769230769230769 0.786920543781137 0.828557001513067 0.999999999999945 GO:0004676 3-phosphoinositide-dependent protein kinase activity 20/1822 245/18639 0.0816326530612245 0.835099352584063 0.832079037449109 0.999999999999945 GO:0004711 ribosomal protein S6 kinase activity 20/1822 245/18639 0.0816326530612245 0.835099352584063 0.832079037449109 0.999999999999945 GO:0035175 histone H3S10 kinase activity 20/1822 245/18639 0.0816326530612245 0.835099352584063 0.832079037449109 0.999999999999945 GO:0035979 histone H2AXS139 kinase activity 20/1822 245/18639 0.0816326530612245 0.835099352584063 0.832079037449109 0.999999999999945 GO:0044022 histone H3S28 kinase activity 20/1822 245/18639 0.0816326530612245 0.835099352584063 0.832079037449109 0.999999999999945 GO:0044023 histone H4S1 kinase activity 20/1822 245/18639 0.0816326530612245 0.835099352584063 0.832079037449109 0.999999999999945 GO:0044024 histone H2AS1 kinase activity 20/1822 245/18639 0.0816326530612245 0.835099352584063 0.832079037449109 0.999999999999945 GO:0044025 histone H2BS14 kinase activity 20/1822 245/18639 0.0816326530612245 0.835099352584063 0.832079037449109 0.999999999999945 GO:0072354 histone H3T3 kinase activity 20/1822 245/18639 0.0816326530612245 0.835099352584063 0.832079037449109 0.999999999999945 GO:0072371 histone H2AS121 kinase activity 20/1822 245/18639 0.0816326530612245 0.835099352584063 0.832079037449109 0.999999999999945 GO:0072518 Rho-dependent protein serine/threonine kinase activity 20/1822 245/18639 0.0816326530612245 0.835099352584063 0.832079037449109 0.999999999999945 GO:0140823 histone H2BS36 kinase activity 20/1822 245/18639 0.0816326530612245 0.835099352584063 0.832079037449109 0.999999999999945 GO:0140855 histone H3S57 kinase activity 20/1822 245/18639 0.0816326530612245 0.835099352584063 0.832079037449109 0.999999999999945 GO:0140995 histone H2A kinase activity 20/1822 245/18639 0.0816326530612245 0.835099352584063 0.832079037449109 0.999999999999945 GO:0140997 histone H4 kinase activity 20/1822 245/18639 0.0816326530612245 0.835099352584063 0.832079037449109 0.999999999999945 GO:0140998 histone H2B kinase activity 20/1822 245/18639 0.0816326530612245 0.835099352584063 0.832079037449109 0.999999999999945 GO:1990244 histone H2AT120 kinase activity 20/1822 245/18639 0.0816326530612245 0.835099352584063 0.832079037449109 0.999999999999945 GO:0008276 protein methyltransferase activity 7/1822 95/18639 0.0736842105263158 0.753787047200878 0.832554158820527 0.999999999999945 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 2/1822 32/18639 0.0625 0.639372941822173 0.834113672924023 0.999999999999945 GO:0047498 calcium-dependent phospholipase A2 activity 2/1822 32/18639 0.0625 0.639372941822173 0.834113672924023 0.999999999999945 GO:0004677 DNA-dependent protein kinase activity 20/1822 246/18639 0.0813008130081301 0.831704639768681 0.837142422219065 0.999999999999945 GO:0140857 histone H3T45 kinase activity 20/1822 246/18639 0.0813008130081301 0.831704639768681 0.837142422219065 0.999999999999945 GO:0032182 ubiquitin-like protein binding 9/1822 120/18639 0.075 0.767247530186608 0.840903320979153 0.999999999999945 GO:0070888 E-box binding 4/1822 59/18639 0.0677966101694915 0.693557089434222 0.84122691969585 0.999999999999945 GO:0035402 histone H3T11 kinase activity 20/1822 247/18639 0.0809716599190283 0.82833741450646 0.842092023020728 0.999999999999945 GO:0000400 four-way junction DNA binding 1/1822 18/18639 0.0555555555555556 0.568331503841932 0.843151635686391 0.999999999999945 GO:0017075 syntaxin-1 binding 1/1822 18/18639 0.0555555555555556 0.568331503841932 0.843151635686391 0.999999999999945 GO:0022851 GABA-gated chloride ion channel activity 1/1822 18/18639 0.0555555555555556 0.568331503841932 0.843151635686391 0.999999999999945 GO:0034185 apolipoprotein binding 1/1822 18/18639 0.0555555555555556 0.568331503841932 0.843151635686391 0.999999999999945 GO:0050811 GABA receptor binding 1/1822 18/18639 0.0555555555555556 0.568331503841932 0.843151635686391 0.999999999999945 GO:1901611 phosphatidylglycerol binding 1/1822 18/18639 0.0555555555555556 0.568331503841932 0.843151635686391 0.999999999999945 GO:1990381 ubiquitin-specific protease binding 1/1822 18/18639 0.0555555555555556 0.568331503841932 0.843151635686391 0.999999999999945 GO:0140416 transcription regulator inhibitor activity 2/1822 33/18639 0.0606060606060606 0.619998004191199 0.846719183068338 0.999999999999945 GO:0004679 AMP-activated protein kinase activity 20/1822 248/18639 0.0806451612903226 0.824997344286675 0.846928729219504 0.999999999999945 GO:0106310 protein serine kinase activity 30/1822 361/18639 0.0831024930747922 0.850135767519787 0.850499534742411 0.999999999999945 GO:0001098 basal transcription machinery binding 4/1822 60/18639 0.0666666666666667 0.681997804610318 0.850576636726669 0.999999999999945 GO:0001099 basal RNA polymerase II transcription machinery binding 4/1822 60/18639 0.0666666666666667 0.681997804610318 0.850576636726669 0.999999999999945 GO:0008175 tRNA methyltransferase activity 2/1822 34/18639 0.0588235294117647 0.60176276877381 0.858447038125715 0.999999999999945 GO:0015020 glucuronosyltransferase activity 2/1822 34/18639 0.0588235294117647 0.60176276877381 0.858447038125715 0.999999999999945 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 2/1822 34/18639 0.0588235294117647 0.60176276877381 0.858447038125715 0.999999999999945 GO:0052866 phosphatidylinositol phosphate phosphatase activity 2/1822 34/18639 0.0588235294117647 0.60176276877381 0.858447038125715 0.999999999999945 GO:0003756 protein disulfide isomerase activity 1/1822 19/18639 0.0526315789473684 0.538419319429199 0.858498701890107 0.999999999999945 GO:0004890 GABA-A receptor activity 1/1822 19/18639 0.0526315789473684 0.538419319429199 0.858498701890107 0.999999999999945 GO:0008301 DNA binding, bending 1/1822 19/18639 0.0526315789473684 0.538419319429199 0.858498701890107 0.999999999999945 GO:0008381 mechanosensitive monoatomic ion channel activity 1/1822 19/18639 0.0526315789473684 0.538419319429199 0.858498701890107 0.999999999999945 GO:0008574 plus-end-directed microtubule motor activity 1/1822 19/18639 0.0526315789473684 0.538419319429199 0.858498701890107 0.999999999999945 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 1/1822 19/18639 0.0526315789473684 0.538419319429199 0.858498701890107 0.999999999999945 GO:0031420 alkali metal ion binding 1/1822 19/18639 0.0526315789473684 0.538419319429199 0.858498701890107 0.999999999999945 GO:0050145 nucleoside monophosphate kinase activity 1/1822 19/18639 0.0526315789473684 0.538419319429199 0.858498701890107 0.999999999999945 GO:0120227 acyl-CoA binding 1/1822 19/18639 0.0526315789473684 0.538419319429199 0.858498701890107 0.999999999999945 GO:1990380 K48-linked deubiquitinase activity 1/1822 19/18639 0.0526315789473684 0.538419319429199 0.858498701890107 0.999999999999945 GO:0140693 molecular condensate scaffold activity 3/1822 48/18639 0.0625 0.639372941822173 0.86090453658863 0.999999999999945 GO:0043022 ribosome binding 8/1822 112/18639 0.0714285714285714 0.730711933511055 0.867320018254762 0.999999999999945 GO:0043130 ubiquitin binding 7/1822 100/18639 0.07 0.716097694840834 0.868837701030104 0.999999999999945 GO:0000175 3'-5'-RNA exonuclease activity 2/1822 35/18639 0.0571428571428571 0.584569546808844 0.869348261489741 0.999999999999945 GO:0016229 steroid dehydrogenase activity 2/1822 35/18639 0.0571428571428571 0.584569546808844 0.869348261489741 0.999999999999945 GO:0043015 gamma-tubulin binding 2/1822 35/18639 0.0571428571428571 0.584569546808844 0.869348261489741 0.999999999999945 GO:0061631 ubiquitin conjugating enzyme activity 2/1822 35/18639 0.0571428571428571 0.584569546808844 0.869348261489741 0.999999999999945 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 1/1822 20/18639 0.05 0.511498353457739 0.872344854691194 0.999999999999945 GO:0005326 neurotransmitter transmembrane transporter activity 1/1822 20/18639 0.05 0.511498353457739 0.872344854691194 0.999999999999945 GO:0015095 magnesium ion transmembrane transporter activity 1/1822 20/18639 0.05 0.511498353457739 0.872344854691194 0.999999999999945 GO:0016408 C-acyltransferase activity 1/1822 20/18639 0.05 0.511498353457739 0.872344854691194 0.999999999999945 GO:0140664 ATP-dependent DNA damage sensor activity 1/1822 20/18639 0.05 0.511498353457739 0.872344854691194 0.999999999999945 GO:0051536 iron-sulfur cluster binding 5/1822 76/18639 0.0657894736842105 0.673024149286498 0.876188754309859 0.999999999999945 GO:0003727 single-stranded RNA binding 6/1822 89/18639 0.0674157303370786 0.689660701291333 0.878306513005381 0.999999999999945 GO:0015605 organophosphate ester transmembrane transporter activity 3/1822 50/18639 0.06 0.613798024149286 0.878916381154752 0.999999999999945 GO:0005484 SNAP receptor activity 2/1822 36/18639 0.0555555555555556 0.568331503841932 0.879472293407235 0.999999999999945 GO:0044390 ubiquitin-like protein conjugating enzyme binding 2/1822 36/18639 0.0555555555555556 0.568331503841932 0.879472293407235 0.999999999999945 GO:0003713 transcription coactivator activity 20/1822 256/18639 0.078125 0.799216177277717 0.881686335475665 0.999999999999945 GO:0051540 metal cluster binding 5/1822 77/18639 0.0649350649350649 0.664283575919141 0.883140530683175 0.999999999999945 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 1/1822 21/18639 0.0476190476190476 0.48714128900737 0.884836807790321 0.999999999999945 GO:0005123 death receptor binding 1/1822 21/18639 0.0476190476190476 0.48714128900737 0.884836807790321 0.999999999999945 GO:0005248 voltage-gated sodium channel activity 1/1822 21/18639 0.0476190476190476 0.48714128900737 0.884836807790321 0.999999999999945 GO:0019200 carbohydrate kinase activity 1/1822 21/18639 0.0476190476190476 0.48714128900737 0.884836807790321 0.999999999999945 GO:0035613 RNA stem-loop binding 1/1822 21/18639 0.0476190476190476 0.48714128900737 0.884836807790321 0.999999999999945 GO:0070182 DNA polymerase binding 1/1822 21/18639 0.0476190476190476 0.48714128900737 0.884836807790321 0.999999999999945 GO:0003743 translation initiation factor activity 3/1822 51/18639 0.0588235294117647 0.60176276877381 0.887120254222623 0.999999999999945 GO:0030544 Hsp70 protein binding 3/1822 51/18639 0.0588235294117647 0.60176276877381 0.887120254222623 0.999999999999945 GO:0022829 wide pore channel activity 2/1822 37/18639 0.0540540540540541 0.552971192927285 0.888866812872093 0.999999999999945 GO:0003774 cytoskeletal motor activity 11/1822 153/18639 0.0718954248366013 0.735487828501324 0.892642284420667 0.999999999999945 GO:0008186 ATP-dependent activity, acting on RNA 5/1822 79/18639 0.0632911392405063 0.647466270199669 0.896045357132188 0.999999999999945 GO:0005243 gap junction channel activity 1/1822 22/18639 0.0454545454545455 0.464998503143399 0.896106940790967 0.999999999999945 GO:0008970 phospholipase A1 activity 1/1822 22/18639 0.0454545454545455 0.464998503143399 0.896106940790967 0.999999999999945 GO:0016881 acid-amino acid ligase activity 1/1822 22/18639 0.0454545454545455 0.464998503143399 0.896106940790967 0.999999999999945 GO:0032931 histone H3K56 acetyltransferase activity 1/1822 22/18639 0.0454545454545455 0.464998503143399 0.896106940790967 0.999999999999945 GO:0034062 5'-3' RNA polymerase activity 1/1822 22/18639 0.0454545454545455 0.464998503143399 0.896106940790967 0.999999999999945 GO:0043992 histone H3K9 acetyltransferase activity 1/1822 22/18639 0.0454545454545455 0.464998503143399 0.896106940790967 0.999999999999945 GO:0043993 histone H3K18 acetyltransferase activity 1/1822 22/18639 0.0454545454545455 0.464998503143399 0.896106940790967 0.999999999999945 GO:0043994 histone H3K23 acetyltransferase activity 1/1822 22/18639 0.0454545454545455 0.464998503143399 0.896106940790967 0.999999999999945 GO:0043999 histone H2AK5 acetyltransferase activity 1/1822 22/18639 0.0454545454545455 0.464998503143399 0.896106940790967 0.999999999999945 GO:0044012 histone H2AK9 acetyltransferase activity 1/1822 22/18639 0.0454545454545455 0.464998503143399 0.896106940790967 0.999999999999945 GO:0044014 histone H2BK5 acetyltransferase activity 1/1822 22/18639 0.0454545454545455 0.464998503143399 0.896106940790967 0.999999999999945 GO:0044015 histone H2BK12 acetyltransferase activity 1/1822 22/18639 0.0454545454545455 0.464998503143399 0.896106940790967 0.999999999999945 GO:0044016 histone H3K4 acetyltransferase activity 1/1822 22/18639 0.0454545454545455 0.464998503143399 0.896106940790967 0.999999999999945 GO:0044017 histone H3K27 acetyltransferase activity 1/1822 22/18639 0.0454545454545455 0.464998503143399 0.896106940790967 0.999999999999945 GO:0044018 histone H3K36 acetyltransferase activity 1/1822 22/18639 0.0454545454545455 0.464998503143399 0.896106940790967 0.999999999999945 GO:0046972 histone H4K16 acetyltransferase activity 1/1822 22/18639 0.0454545454545455 0.464998503143399 0.896106940790967 0.999999999999945 GO:0097747 RNA polymerase activity 1/1822 22/18639 0.0454545454545455 0.464998503143399 0.896106940790967 0.999999999999945 GO:0140908 histone H3K122 acetyltransferase activity 1/1822 22/18639 0.0454545454545455 0.464998503143399 0.896106940790967 0.999999999999945 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 2/1822 38/18639 0.0526315789473684 0.538419319429199 0.897577609425319 0.999999999999945 GO:0005283 amino acid:sodium symporter activity 1/1822 23/18639 0.0434782608695652 0.444781176919773 0.906274698962469 0.999999999999945 GO:0044013 histone H2B acetyltransferase activity 1/1822 23/18639 0.0434782608695652 0.444781176919773 0.906274698962469 0.999999999999945 GO:0003925 G protein activity 3/1822 54/18639 0.0555555555555556 0.568331503841932 0.908826238667434 0.999999999999945 GO:0004532 RNA exonuclease activity 2/1822 40/18639 0.05 0.511498353457739 0.913121261565519 0.999999999999945 GO:0032451 demethylase activity 2/1822 40/18639 0.05 0.511498353457739 0.913121261565519 0.999999999999945 GO:0050997 quaternary ammonium group binding 2/1822 40/18639 0.05 0.511498353457739 0.913121261565519 0.999999999999945 GO:0061791 GTPase motor activity 2/1822 40/18639 0.05 0.511498353457739 0.913121261565519 0.999999999999945 GO:0140662 ATP-dependent protein folding chaperone 2/1822 40/18639 0.05 0.511498353457739 0.913121261565519 0.999999999999945 GO:1990606 membrane scission GTPase motor activity 2/1822 40/18639 0.05 0.511498353457739 0.913121261565519 0.999999999999945 GO:0005315 phosphate transmembrane transporter activity 1/1822 24/18639 0.0416666666666667 0.426248627881449 0.915447856380302 0.999999999999945 GO:0042625 ATPase-coupled ion transmembrane transporter activity 1/1822 24/18639 0.0416666666666667 0.426248627881449 0.915447856380302 0.999999999999945 GO:0043998 histone H2A acetyltransferase activity 1/1822 24/18639 0.0416666666666667 0.426248627881449 0.915447856380302 0.999999999999945 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 1/1822 24/18639 0.0416666666666667 0.426248627881449 0.915447856380302 0.999999999999945 GO:0046961 proton-transporting ATPase activity, rotational mechanism 1/1822 24/18639 0.0416666666666667 0.426248627881449 0.915447856380302 0.999999999999945 GO:0050699 WW domain binding 1/1822 24/18639 0.0416666666666667 0.426248627881449 0.915447856380302 0.999999999999945 GO:0140612 DNA damage sensor activity 1/1822 24/18639 0.0416666666666667 0.426248627881449 0.915447856380302 0.999999999999945 GO:0008080 N-acetyltransferase activity 4/1822 69/18639 0.0579710144927536 0.593041569226364 0.915510460481336 0.999999999999945 GO:0008135 translation factor activity, RNA binding 5/1822 83/18639 0.0602409638554217 0.616263076455107 0.918190646074142 0.999999999999945 GO:0001727 lipid kinase activity 2/1822 41/18639 0.0487804878048781 0.499022783861209 0.92003564046086 0.999999999999945 GO:0008227 G protein-coupled amine receptor activity 2/1822 41/18639 0.0487804878048781 0.499022783861209 0.92003564046086 0.999999999999945 GO:0061650 ubiquitin-like protein conjugating enzyme activity 2/1822 41/18639 0.0487804878048781 0.499022783861209 0.92003564046086 0.999999999999945 GO:0030170 pyridoxal phosphate binding 3/1822 56/18639 0.0535714285714286 0.548033950133291 0.921116101847251 0.999999999999945 GO:0180051 translation factor activity 5/1822 84/18639 0.0595238095238095 0.608926611259213 0.923031284734408 0.999999999999945 GO:0000030 mannosyltransferase activity 1/1822 25/18639 0.04 0.409198682766191 0.923723655771927 0.999999999999945 GO:0015645 fatty acid ligase activity 1/1822 25/18639 0.04 0.409198682766191 0.923723655771927 0.999999999999945 GO:0017056 structural constituent of nuclear pore 1/1822 25/18639 0.04 0.409198682766191 0.923723655771927 0.999999999999945 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 1/1822 25/18639 0.04 0.409198682766191 0.923723655771927 0.999999999999945 GO:0120515 fatty acid-CoA ligase activity 1/1822 25/18639 0.04 0.409198682766191 0.923723655771927 0.999999999999945 GO:0031492 nucleosomal DNA binding 2/1822 42/18639 0.0476190476190476 0.48714128900737 0.92642932178862 0.999999999999945 GO:0070279 vitamin B6 binding 3/1822 57/18639 0.0526315789473684 0.538419319429199 0.926675305010902 0.999999999999945 GO:0008143 poly(A) binding 1/1822 26/18639 0.0384615384615385 0.393460271890568 0.931189837096927 0.999999999999945 GO:0034237 protein kinase A regulatory subunit binding 1/1822 26/18639 0.0384615384615385 0.393460271890568 0.931189837096927 0.999999999999945 GO:0051139 metal cation:proton antiporter activity 1/1822 26/18639 0.0384615384615385 0.393460271890568 0.931189837096927 0.999999999999945 GO:0097602 cullin family protein binding 1/1822 26/18639 0.0384615384615385 0.393460271890568 0.931189837096927 0.999999999999945 GO:0043021 ribonucleoprotein complex binding 12/1822 177/18639 0.0677966101694915 0.693557089434222 0.936341997603758 0.999999999999945 GO:0036002 pre-mRNA binding 3/1822 59/18639 0.0508474576271186 0.520167817075667 0.936728702231643 0.999999999999945 GO:0005104 fibroblast growth factor receptor binding 1/1822 27/18639 0.037037037037037 0.378887669227955 0.937925565717214 0.999999999999945 GO:0005385 zinc ion transmembrane transporter activity 1/1822 27/18639 0.037037037037037 0.378887669227955 0.937925565717214 0.999999999999945 GO:0016405 CoA-ligase activity 1/1822 27/18639 0.037037037037037 0.378887669227955 0.937925565717214 0.999999999999945 GO:0031491 nucleosome binding 4/1822 74/18639 0.0540540540540541 0.552971192927285 0.939459312108649 0.999999999999945 GO:0046982 protein heterodimerization activity 28/1822 369/18639 0.0758807588075881 0.776257663784102 0.939664898680105 0.999999999999945 GO:0046915 transition metal ion transmembrane transporter activity 2/1822 45/18639 0.0444444444444444 0.454665203073546 0.942832873493721 0.999999999999945 GO:0051539 4 iron, 4 sulfur cluster binding 2/1822 45/18639 0.0444444444444444 0.454665203073546 0.942832873493721 0.999999999999945 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 11/1822 167/18639 0.0658682634730539 0.673830166231752 0.943193037185681 0.999999999999945 GO:0008527 taste receptor activity 1/1822 28/18639 0.0357142857142857 0.365355966755528 0.944002269954439 0.999999999999945 GO:0019789 SUMO transferase activity 1/1822 28/18639 0.0357142857142857 0.365355966755528 0.944002269954439 0.999999999999945 GO:0036408 histone H3K14 acetyltransferase activity 1/1822 28/18639 0.0357142857142857 0.365355966755528 0.944002269954439 0.999999999999945 GO:0141052 histone H3 demethylase activity 1/1822 28/18639 0.0357142857142857 0.365355966755528 0.944002269954439 0.999999999999945 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 1/1822 29/18639 0.0344827586206897 0.352757485143268 0.949484396876314 0.999999999999945 GO:0010484 histone H3 acetyltransferase activity 1/1822 29/18639 0.0344827586206897 0.352757485143268 0.949484396876314 0.999999999999945 GO:0097472 cyclin-dependent protein kinase activity 1/1822 29/18639 0.0344827586206897 0.352757485143268 0.949484396876314 0.999999999999945 GO:0003724 RNA helicase activity 4/1822 77/18639 0.051948051948052 0.531426860735313 0.950679578135445 0.999999999999945 GO:0031624 ubiquitin conjugating enzyme binding 1/1822 30/18639 0.0333333333333333 0.340998902305159 0.954430094291217 0.999999999999945 GO:0032452 histone demethylase activity 1/1822 30/18639 0.0333333333333333 0.340998902305159 0.954430094291217 0.999999999999945 GO:0035925 mRNA 3'-UTR AU-rich region binding 1/1822 30/18639 0.0333333333333333 0.340998902305159 0.954430094291217 0.999999999999945 GO:0043995 histone H4K5 acetyltransferase activity 1/1822 30/18639 0.0333333333333333 0.340998902305159 0.954430094291217 0.999999999999945 GO:0043996 histone H4K8 acetyltransferase activity 1/1822 30/18639 0.0333333333333333 0.340998902305159 0.954430094291217 0.999999999999945 GO:0043997 histone H4K12 acetyltransferase activity 1/1822 30/18639 0.0333333333333333 0.340998902305159 0.954430094291217 0.999999999999945 GO:0008188 neuropeptide receptor activity 2/1822 48/18639 0.0416666666666667 0.426248627881449 0.955717277518246 0.999999999999945 GO:0042393 histone binding 17/1822 247/18639 0.0688259109311741 0.704086802330491 0.956146838806379 0.999999999999945 GO:0003712 transcription coregulator activity 38/1822 495/18639 0.0767676767676768 0.785330805308851 0.956355126752958 0.999999999999945 GO:0008327 methyl-CpG binding 1/1822 31/18639 0.032258064516129 0.32999893771467 0.95889182615222 0.999999999999945 GO:0016878 acid-thiol ligase activity 1/1822 31/18639 0.032258064516129 0.32999893771467 0.95889182615222 0.999999999999945 GO:0017147 Wnt-protein binding 1/1822 31/18639 0.032258064516129 0.32999893771467 0.95889182615222 0.999999999999945 GO:0140457 protein demethylase activity 1/1822 31/18639 0.032258064516129 0.32999893771467 0.95889182615222 0.999999999999945 GO:0000049 tRNA binding 4/1822 80/18639 0.05 0.511498353457739 0.959959085288009 0.999999999999945 GO:0008234 cysteine-type peptidase activity 12/1822 187/18639 0.0641711229946524 0.656468475025975 0.960118769708628 0.999999999999945 GO:0016887 ATP hydrolysis activity 31/1822 417/18639 0.0743405275779376 0.760501149025894 0.960735220057102 0.999999999999945 GO:0030515 snoRNA binding 1/1822 32/18639 0.03125 0.319686470911087 0.962916927869259 0.999999999999945 GO:0016407 acetyltransferase activity 5/1822 96/18639 0.0520833333333333 0.532810784851811 0.964109687003957 0.999999999999945 GO:0005272 sodium channel activity 2/1822 51/18639 0.0392156862745098 0.40117517918254 0.965793814675991 0.999999999999945 GO:0042923 neuropeptide binding 1/1822 33/18639 0.0303030303030303 0.309999002095599 0.966548107394288 0.999999999999945 GO:0008168 methyltransferase activity 13/1822 204/18639 0.0637254901960784 0.651909666171628 0.967573257436335 0.999999999999945 GO:0003777 microtubule motor activity 3/1822 68/18639 0.0441176470588235 0.451322076580358 0.968041045675894 0.999999999999945 GO:0016831 carboxy-lyase activity 1/1822 34/18639 0.0294117647058824 0.300881384386905 0.969823897372123 0.999999999999945 GO:0004527 exonuclease activity 4/1822 84/18639 0.0476190476190476 0.48714128900737 0.96982652147275 0.999999999999945 GO:0002039 p53 binding 3/1822 69/18639 0.0434782608695652 0.444781176919773 0.970428799548374 0.999999999999945 GO:0042826 histone deacetylase binding 7/1822 127/18639 0.0551181102362205 0.563856452630578 0.970480316506185 0.999999999999945 GO:0016251 RNA polymerase II general transcription initiation factor activity 2/1822 53/18639 0.0377358490566038 0.386036493175652 0.971243690352049 0.999999999999945 GO:0051018 protein kinase A binding 2/1822 53/18639 0.0377358490566038 0.386036493175652 0.971243690352049 0.999999999999945 GO:0005343 organic acid:sodium symporter activity 1/1822 35/18639 0.0285714285714286 0.292284773404422 0.97277906313337 0.999999999999945 GO:0010485 histone H4 acetyltransferase activity 1/1822 35/18639 0.0285714285714286 0.292284773404422 0.97277906313337 0.999999999999945 GO:0000993 RNA polymerase II complex binding 1/1822 36/18639 0.0277777777777778 0.284165751920966 0.975444970839831 0.999999999999945 GO:0019213 deacetylase activity 1/1822 37/18639 0.027027027027027 0.276485596463643 0.977849919672268 0.999999999999945 GO:0070001 aspartic-type peptidase activity 1/1822 37/18639 0.027027027027027 0.276485596463643 0.977849919672268 0.999999999999945 GO:0005179 hormone activity 7/1822 132/18639 0.053030303030303 0.542498253667299 0.978201346809081 0.999999999999945 GO:0042162 telomeric DNA binding 1/1822 38/18639 0.0263157894736842 0.269209659714599 0.980019441570834 0.999999999999945 GO:0003684 damaged DNA binding 3/1822 74/18639 0.0405405405405405 0.414728394695464 0.980037293477474 0.999999999999945 GO:0016741 transferase activity, transferring one-carbon groups 13/1822 215/18639 0.0604651162790698 0.618556148367498 0.981113316605725 0.999999999999945 GO:0008408 3'-5' exonuclease activity 2/1822 58/18639 0.0344827586206897 0.352757485143268 0.981449470822137 0.999999999999945 GO:0016776 phosphotransferase activity, phosphate group as acceptor 1/1822 39/18639 0.0256410256410256 0.262306847927046 0.981976571695985 0.999999999999945 GO:0031593 polyubiquitin modification-dependent protein binding 2/1822 59/18639 0.0338983050847458 0.346778544717111 0.983018620597242 0.999999999999945 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 6/1822 122/18639 0.0491803278688525 0.503113134548596 0.983305942393234 0.999999999999945 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 2/1822 60/18639 0.0333333333333333 0.340998902305159 0.984458468843052 0.999999999999945 GO:0015175 neutral L-amino acid transmembrane transporter activity 1/1822 41/18639 0.024390243902439 0.249511391930604 0.985334753768754 0.999999999999945 GO:0016877 ligase activity, forming carbon-sulfur bonds 1/1822 41/18639 0.024390243902439 0.249511391930604 0.985334753768754 0.999999999999945 GO:0019905 syntaxin binding 2/1822 61/18639 0.0327868852459016 0.33540875636573 0.985779283034664 0.999999999999945 GO:0140101 catalytic activity, acting on a tRNA 7/1822 139/18639 0.0503597122302158 0.515178197727219 0.985910875101615 0.999999999999945 GO:0004402 histone acetyltransferase activity 1/1822 42/18639 0.0238095238095238 0.243570644503685 0.986771471621928 0.999999999999945 GO:0004520 DNA endonuclease activity 1/1822 42/18639 0.0238095238095238 0.243570644503685 0.986771471621928 0.999999999999945 GO:0043175 RNA polymerase core enzyme binding 1/1822 42/18639 0.0238095238095238 0.243570644503685 0.986771471621928 0.999999999999945 GO:0016790 thiolester hydrolase activity 1/1822 44/18639 0.0227272727272727 0.232499251571699 0.989236629938497 0.999999999999945 GO:0019205 nucleobase-containing compound kinase activity 1/1822 44/18639 0.0227272727272727 0.232499251571699 0.989236629938497 0.999999999999945 GO:0140030 modification-dependent protein binding 9/1822 173/18639 0.0520231213872832 0.532194818626549 0.990118768498492 0.999999999999945 GO:0008173 RNA methyltransferase activity 2/1822 67/18639 0.0298507462686567 0.305372151318053 0.991688722574281 0.999999999999945 GO:0061733 protein-lysine-acetyltransferase activity 1/1822 47/18639 0.0212765957446809 0.217658873811804 0.992100777383947 0.999999999999945 GO:0061749 forked DNA-dependent helicase activity 1/1822 47/18639 0.0212765957446809 0.217658873811804 0.992100777383947 0.999999999999945 GO:1990518 single-stranded 3'-5' DNA helicase activity 1/1822 47/18639 0.0212765957446809 0.217658873811804 0.992100777383947 0.999999999999945 GO:0140223 general transcription initiation factor activity 2/1822 68/18639 0.0294117647058824 0.300881384386905 0.992405318843929 0.999999999999945 GO:0009378 four-way junction helicase activity 1/1822 48/18639 0.0208333333333333 0.213124313940724 0.992874894402366 0.999999999999945 GO:0016879 ligase activity, forming carbon-nitrogen bonds 1/1822 48/18639 0.0208333333333333 0.213124313940724 0.992874894402366 0.999999999999945 GO:0036121 double-stranded DNA helicase activity 1/1822 48/18639 0.0208333333333333 0.213124313940724 0.992874894402366 0.999999999999945 GO:0043138 3'-5' DNA helicase activity 1/1822 48/18639 0.0208333333333333 0.213124313940724 0.992874894402366 0.999999999999945 GO:0140767 enzyme-substrate adaptor activity 6/1822 139/18639 0.0431654676258993 0.441581312337616 0.99473198979015 0.999999999999945 GO:0005048 signal sequence binding 1/1822 51/18639 0.0196078431372549 0.20058758959127 0.994771261390589 0.999999999999945 GO:0016830 carbon-carbon lyase activity 1/1822 51/18639 0.0196078431372549 0.20058758959127 0.994771261390589 0.999999999999945 GO:0034212 protein N-acetyltransferase activity 1/1822 53/18639 0.0188679245283019 0.193018246587826 0.995746093026199 0.999999999999945 GO:0031490 chromatin DNA binding 5/1822 128/18639 0.0390625 0.399608088638858 0.996233329845723 0.999999999999945 GO:0061630 ubiquitin protein ligase activity 21/1822 353/18639 0.0594900849858357 0.608581610346318 0.996457059911054 0.999999999999945 GO:0017116 single-stranded DNA helicase activity 1/1822 58/18639 0.0172413793103448 0.176378742571634 0.997460658066084 0.999999999999945 GO:0000510 H3-H4 histone complex chaperone activity 6/1822 151/18639 0.0397350993377483 0.406488757714759 0.997757798137388 0.999999999999945 GO:0140584 chromatin extrusion motor activity 6/1822 151/18639 0.0397350993377483 0.406488757714759 0.997757798137388 0.999999999999945 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 6/1822 151/18639 0.0397350993377483 0.406488757714759 0.997757798137388 0.999999999999945 GO:0140849 ATP-dependent H2AZ histone chaperone activity 6/1822 151/18639 0.0397350993377483 0.406488757714759 0.997757798137388 0.999999999999945 GO:0015616 DNA translocase activity 6/1822 152/18639 0.0394736842105263 0.403814489571899 0.997914612847318 0.999999999999945 GO:0140674 ATP-dependent histone chaperone activity 6/1822 152/18639 0.0394736842105263 0.403814489571899 0.997914612847318 0.999999999999945 GO:0061775 cohesin loader activity 6/1822 153/18639 0.0392156862745098 0.40117517918254 0.998060833346609 0.999999999999945 GO:0004386 helicase activity 6/1822 155/18639 0.0387096774193548 0.395998725257604 0.998324188557004 0.999999999999945 GO:0140597 protein carrier chaperone 8/1822 188/18639 0.0425531914893617 0.435317747623607 0.998522516124671 0.999999999999945 GO:0061659 ubiquitin-like protein ligase activity 21/1822 372/18639 0.0564516129032258 0.577498141000673 0.998626940140275 0.999999999999945 GO:0004536 DNA nuclease activity 1/1822 64/18639 0.015625 0.159843235455543 0.998633035719225 0.999999999999945 GO:0140658 ATP-dependent chromatin remodeler activity 6/1822 158/18639 0.0379746835443038 0.388479762119802 0.998655574513455 0.999999999999945 GO:0140104 molecular carrier activity 12/1822 249/18639 0.0481927710843374 0.493010461164086 0.998693590307474 0.999999999999945 GO:0160215 deacylase activity 1/1822 65/18639 0.0153846153846154 0.157384108756227 0.998767119644908 0.999999999999945 GO:0003689 DNA clamp loader activity 6/1822 160/18639 0.0375 0.383623765093304 0.998840281770399 0.999999999999945 GO:0019783 ubiquitin-like protein peptidase activity 4/1822 127/18639 0.031496062992126 0.322203687217473 0.99890126477887 0.999999999999945 GO:0140713 histone chaperone activity 6/1822 164/18639 0.0365853658536585 0.374267087895906 0.999138860227441 0.999999999999945 GO:0101005 deubiquitinase activity 3/1822 115/18639 0.0260869565217391 0.266868706151864 0.999358412828775 0.999999999999945 GO:0140098 catalytic activity, acting on RNA 21/1822 387/18639 0.0542635658914729 0.555114492124678 0.999373133436762 0.999999999999945 GO:0003678 DNA helicase activity 1/1822 74/18639 0.0135135135135135 0.138242798231821 0.999513278691234 0.999999999999945 GO:0035064 methylated histone binding 1/1822 74/18639 0.0135135135135135 0.138242798231821 0.999513278691234 0.999999999999945 GO:0140034 methylation-dependent protein binding 1/1822 76/18639 0.0131578947368421 0.1346048298573 0.999604128294908 0.999999999999945 GO:0008094 ATP-dependent activity, acting on DNA 8/1822 210/18639 0.0380952380952381 0.389713031205896 0.999683578187462 0.999999999999945 GO:0004842 ubiquitin-protein transferase activity 24/1822 449/18639 0.0534521158129176 0.546813384542794 0.999798991568276 0.999999999999945 GO:0004843 cysteine-type deubiquitinase activity 2/1822 108/18639 0.0185185185185185 0.189443834613977 0.999815095971757 0.999999999999945 GO:0016874 ligase activity 5/1822 167/18639 0.029940119760479 0.306286439196251 0.999819692253954 0.999999999999945 GO:0019787 ubiquitin-like protein transferase activity 25/1822 479/18639 0.0521920668058455 0.533923124694926 0.99991702127976 0.999999999999945 GO:0016755 aminoacyltransferase activity 26/1822 496/18639 0.0524193548387097 0.536248273786339 0.999930628800356 0.999999999999945 GO:0003697 single-stranded DNA binding 2/1822 121/18639 0.0165289256198347 0.169090364779418 0.999946491103195 0.999999999999945 GO:0005549 odorant binding 1/1822 111/18639 0.00900900900900901 0.0921618654878808 0.999989390362052 0.999999999999945 GO:0140097 catalytic activity, acting on DNA 11/1822 336/18639 0.0327380952380952 0.334909636192567 0.999998879151101 0.999999999999945 GO:0003730 mRNA 3'-UTR binding 6/1822 262/18639 0.0229007633587786 0.234274055018812 0.999999691066801 0.999999999999945 GO:0045182 translation regulator activity 10/1822 356/18639 0.0280898876404494 0.287358625538055 0.999999938004361 0.999999999999945 GO:0004984 olfactory receptor activity 6/1822 419/18639 0.0143198090692124 0.146491175214627 0.999999999999775 0.999999999999945 GO:0030371 translation repressor activity 2/1822 329/18639 0.0060790273556231 0.0621882496605154 0.999999999999945 0.999999999999945