category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	7/24	174/9376	15.7164750957854	XBP1/HERPUD1/UBE2J1/SEC31A/DERL3/SEL1L/RRBP1	9.92604682229166
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	2/24	56/9376	13.952380952381	FUT8/ST6GAL1	4.92464213538337
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	2/24	90/9376	8.68148148148148	FOXO3/CREB3L2	3.70929106101221
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/24	14/9376	27.9047619047619	FUT8	5.10326196533082
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	2/24	122/9376	6.40437158469945	FOXO3/CREB3L2	3.04368272651174
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	2/24	142/9376	5.50234741784038	UBE2J1/FBXW7	2.7385914680214
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/24	21/9376	18.6031746031746	CSGALNACT1	4.09088958759488
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	2/24	201/9376	3.88723051409619	FUT8/CDK14	2.09611671516898
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	1/24	44/9376	8.87878787878788	FUT8	2.65361180935334
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	1/24	44/9376	8.87878787878788	CREB3L2	2.65361180935334
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	1/24	49/9376	7.97278911564626	ST6GAL1	2.4789775414771
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/24	49/9376	7.97278911564626	CREB3L2	2.4789775414771
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	1/24	52/9376	7.51282051282051	BMP6	2.38566060476874
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	1/24	59/9376	6.62146892655367	FOXO3	2.19420288850928
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	1/24	62/9376	6.3010752688172	FOXO3	2.1214397820727
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	2/24	268/9376	2.91542288557214	XBP1/UBE2J1	1.611608569826
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/24	65/9376	6.01025641025641	PLPP5	2.05332397143308
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	1/24	65/9376	6.01025641025641	CREB3L2	2.05332397143308
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	1/24	68/9376	5.74509803921569	PIM2	1.9893466591129
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	1/24	69/9376	5.66183574879227	CREB3L2	1.96886376495589
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	1/24	71/9376	5.50234741784038	FOXO3	1.92907449604314
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	1/24	71/9376	5.50234741784038	PDK1	1.92907449604314
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	1/24	73/9376	5.35159817351598	FOXO3	1.89076570045791
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	1/24	75/9376	5.20888888888889	CREB3L2	1.85384013554985
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	1/24	80/9376	4.88333333333333	FOXO3	1.76701654770464
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	1/24	83/9376	4.70682730923695	SFMBT2	1.71831365573582
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	1/24	83/9376	4.70682730923695	ZBP1	1.71831365573582
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	1/24	86/9376	4.54263565891473	CREB3L2	1.67188679791251
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	1/24	87/9376	4.4904214559387	DCC	1.65688369617594
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	1/24	98/9376	3.98639455782313	CREB3L2	1.50546980456994
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	1/24	101/9376	3.86798679867987	CREB3L2	1.46797914465946
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	1/24	103/9376	3.79288025889968	MSI2	1.44377596843024
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	1/24	104/9376	3.75641025641026	PLPP5	1.43190044935673
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	2/24	362/9376	2.15837937384899	FOXO3/CREB3L2	1.1386371104669
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	1/24	105/9376	3.72063492063492	FOXO3	1.42017099029537
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	1/24	106/9376	3.68553459119497	CREB3L2	1.40858424415427
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	1/24	107/9376	3.65109034267913	CREB3L2	1.39713697205745
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	1/24	109/9376	3.58409785932722	CREB3L2	1.37464840889396
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	1/24	110/9376	3.55151515151515	PDK1	1.36360114191379
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	1/24	110/9376	3.55151515151515	BMP6	1.36360114191379
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	1/24	110/9376	3.55151515151515	CPEB4	1.36360114191379
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	1/24	115/9376	3.39710144927536	CREB3L2	1.31022355405774
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	1/24	115/9376	3.39710144927536	CREB3L2	1.31022355405774
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	1/24	119/9376	3.28291316526611	CREB3L2	1.2695995255133
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	1/24	120/9376	3.25555555555556	FOXO3	1.25971264405908
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	1/24	122/9376	3.20218579234973	CREB3L2	1.24024685418022
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	1/24	130/9376	3.00512820512821	CREB3L2	1.16620765447997
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	1/24	133/9376	2.93734335839599	FOXO3	1.13989527162798
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	1/24	133/9376	2.93734335839599	CREB3L2	1.13989527162798
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	1/24	138/9376	2.83091787439614	CPEB4	1.09763624327159
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	1/24	139/9376	2.810551558753	CREB3L2	1.08941119774867
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	1/24	144/9376	2.71296296296296	FOXO3	1.04934991345402
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	1/24	144/9376	2.71296296296296	XBP1	1.04934991345402
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	1/24	154/9376	2.53679653679654	CREB3L2	0.974099195393406
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	1/24	155/9376	2.52043010752688	CREB3L2	0.966901666945962
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	1/24	157/9376	2.48832271762208	FOXO3	0.952673400586972
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	1/24	157/9376	2.48832271762208	BMP6	0.952673400586972
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	1/24	157/9376	2.48832271762208	XBP1	0.952673400586972
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	1/24	163/9376	2.39672801635992	CREB3L2	0.911263806108362
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	1/24	166/9376	2.35341365461847	CREB3L2	0.891238199671625
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	2/24	480/9376	1.62777777777778	XBP1/UBE2J1	0.715266985670553
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	1/24	168/9376	2.32539682539683	ZBP1	0.878126172687019
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	1/24	184/9376	2.1231884057971	DCC	0.779463037223256
Human Diseases	Substance dependence	hsa05034	Alcoholism	1/24	191/9376	2.04537521815009	CREB3L2	0.739415097294565
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	1/24	193/9376	2.02417962003454	FOXO3	0.728285229385329
Cellular Processes	Cell motility	hsa04814	Motor proteins	1/24	194/9376	2.01374570446735	MYO1D	0.722770232511892
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	1/24	200/9376	1.95333333333333	MYO1D	0.690354378676375
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	1/24	205/9376	1.90569105691057	CREB3L2	0.664182874134183
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	1/24	216/9376	1.80864197530864	XBP1	0.609080127299983
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	1/24	217/9376	1.80030721966206	CREB3L2	0.604229023238884
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	1/24	224/9376	1.74404761904762	CREB3L2	0.570960080136197
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	1/24	226/9376	1.72861356932153	CREB3L2	0.561668331241315
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	1/24	227/9376	1.72099853157122	CREB3L2	0.557056832003947
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	1/24	227/9376	1.72099853157122	FOXO3	0.557056832003947
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	1/24	235/9376	1.66241134751773	CREB3L2	0.520959365849918
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	1/24	253/9376	1.54413702239789	FOXO3	0.444466168082036
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	1/24	275/9376	1.42060606060606	CREB3L2	0.358621502653953
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	1/24	298/9376	1.31096196868009	BMP6	0.276349911562988
NA	NA	hsa04517	IgSF CAM signaling	1/24	299/9376	1.30657748049052	DCC	0.272925231405819
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	1/24	308/9376	1.26839826839827	CREB3L2	0.242626549579653
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	1/24	333/9376	1.17317317317317	CREB3L2	0.162999201246848
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	1/24	368/9376	1.06159420289855	XBP1	0.0610644668810745
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	1/24	388/9376	1.00687285223368	XBP1	0.00700422917549315
NA	NA	hsa04519	Cadherin signaling	1/24	404/9376	0.966996699669967	MYO1D	-0.0343512410184038