category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	151/2914	250/9376	1.94341249142073	CTSK/CD68/CTSB/CTSS/ARSG/CTSC/DEPTOR/CD63/NPC2/BLOC1S6/CTSD/MCOLN1/IDS/PSAP/M6PR/CLTB/RRAGA/ARL8A/AP1S2/ATP6V1D/TPP1/CTSH/HEXA/CTSO/GNPTG/ACP2/CTSA/LAMP1/LIPA/OSTM1/OSBPL5/SUMF1/FUCA2/NAGLU/GNS/ARSA/SNAPIN/NCOA7/SCARB2/SGSH/LAMP2/LITAF/ATP6V0A1/ATP6V0D1/LAPTM4A/MITF/AP2M1/DNASE2/GLB1/HYAL2/GALNS/OSBPL1A/VPS13A/KXD1/IGF2R/VPS13C/ASAH1/CTBS/SMPD1/VPS26B/GUSB/VPS41/AP1M1/VPS16/AP3S1/LAPTM5/BLOC1S1/TFE3/AP4M1/LAMTOR1/PPT1/ATP6V0E1/AGA/PLA2G15/RAB7A/HGSNAT/ARL8B/ATP6V1H/VPS26A/DMXL2/ENTPD4/BLOC1S5/DTNBP1/CLTC/CLCN7/NAGPA/BLOC1S2/CTSF/ATP6V1C1/CTSZ/OSBP/SLC15A4/TCIRG1/ATP6V1G1/RRAGD/SLC17A5/TMEM175/ATP6AP1/SLC36A4/RRAGC/RRAGB/ACP5/GNPTAB/GGA1/SLC15A3/AP5Z1/SPG11/FIG4/AP5M1/AP3M1/VPS18/BLOC1S3/SLC11A1/ATP6V0B/AP4S1/AP5S1/CLN8/GPR155/ATP6V1B2/GALC/TLR7/PLEKHM1/WDR7/TPCN1/DMXL1/CTNS/MANBA/MFSD8/LGMN/SLC2A6/ARSB/LAMTOR2/VPS39/PIKFYVE/VPS11/TPCN2/OSBPL2/MTOR/AP3S2/AP2S1/CLTCL1/AP3M2/ZFYVE26/AP4B1/LAMTOR4/ATP6V1E2/MCOLN3/ATP6V1G2/MAN2B1/CTSW/OSBPL7	10.1526246313033
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	111/2914	169/9376	2.11331543700479	IRS2/CTSB/DEPTOR/IRS1/MRAS/CTSD/RRAS/RHEB/PIK3R1/CFLAR/AKT3/IGF1R/RRAGA/VMP1/GABARAPL1/WDR45/GABARAP/MAP1LC3A/PRKACB/RB1CC1/LAMP1/WDR41/OPTN/CALCOCO2/ERN1/LAMP2/DAPK3/BCL2/WIPI1/STX7/BCL2L1/ATG7/TANK/EIF2AK4/NBR1/GABARAPL2/BECN1/ULK1/RRAS2/VPS41/ULK2/VPS16/UVRAG/GORASP2/PDPK1/RAB7A/PIK3CA/HIF1A/ATG5/PRKAA1/AKT2/MAPK1/ATG4A/RAF1/PPP2CA/ATG4B/MAPK10/CAMKK2/PRKACA/SH3GLB1/MAP2K1/MAPK8/WDFY3/RRAGD/STK11/WIPI2/PPP2CB/NRBF2/MAP2K2/RRAGC/KRAS/MAP3K7/TAX1BP1/RRAGB/SUPT20H/BIRC6/RPS6KB1/ATG13/MTMR3/BAD/VPS18/ATG16L2/SQSTM1/MTMR14/ATG16L1/DDIT4/ZFYVE1/ATG14/MAP1LC3B/TRAF6/PIK3C3/RAB33B/PLEKHM1/PIK3CD/DAPK1/EIF2AK3/ATG4D/C9orf72/TP53INP2/ATG2B/PIK3R4/VPS39/VPS11/MTOR/TSC2/ATG2A/EPG5/AMBRA1/DAPK2/PIK3R2/PRKAA2	9.80729969332627
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	146/2914	248/9376	1.89421480284278	SNX9/TUBA1A/MYL9/ACTG1/DYNLT3/PKN1/RRAS/ROCK2/AHNAK2/AKT3/MAPK14/M6PR/TNFRSF1A/ARL8A/STX10/KPNA3/FADD/FLNA/TRADD/DCTN2/TXN/CYTH2/PODXL/KIF5B/DYNC2LI1/FYCO1/MYD88/BCL2/DYNC1LI1/RAB9A/ACTR1A/PLEKHM2/DYNC1H1/KLC1/ACTR10/TUBA3E/RHOB/PAK3/DCTN6/MYO6/RELA/EXOC5/EXOC7/RHOG/ARF1/BIRC2/VPS41/DYNC2H1/CASP1/VPS16/JUN/WASL/IKBKG/RAB7A/RAB5C/RAB5A/PIK3CA/LY96/ARL8B/PFN2/DYNC1LI2/ABI1/AKT2/RALA/MAPK1/RAF1/IL18/IKBKB/BRK1/MAPK10/TUBB2A/ACTR1B/NFKB1/MAP2K1/MAPK8/DYNC1I2/RILP/IRAK1/NCKAP1L/ACBD3/HSP90B1/DCTN1/MAP2K2/TCF7L2/SNX18/MAP3K7/GCC2/MYL5/PYCARD/PTPRC/KPNA1/NAIP/IRAK4/DYNLRB1/KIF5A/TLR4/RAB5B/VPS18/BIRC3/EXOC4/RIPK2/MLKL/MAP2K7/CD14/SNX33/TAB2/CYTH4/RIPK1/MAP2K3/TRAF6/PIK3C3/PLEKHM1/PIK3CD/TLR5/MAP2K4/TLR2/CYTH1/DCTN3/CHUK/RHOA/WASF3/ELMO2/MYC/KLC2/NOD1/VPS39/MYL12B/VPS11/EXOC2/ARHGEF26/AHNAK/TUBB2B/TUBA3D/ARPC2/TAB3/KIF5C/MAPK12/MAPK11/PIK3CG/TUBA4A/TLR6/DYNLRB2/FHOD1/RHOH/RAB9B/PFN4	9.58355886352146
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	96/2914	155/9376	1.99281776518254	C3/ITGB5/TUBA1A/CTSS/HLA-B/HLA-E/HLA-A/ACTG1/HLA-C/THBS1/HLA-DPB1/HLA-DQA2/HLA-DRA/M6PR/ATP6V1D/HLA-F/ITGAV/PLA2R1/HLA-DPA1/LAMP1/HLA-DMB/FCGR3A/STX12/TAP1/MSR1/LAMP2/HLA-DMA/C1R/ATP6V0A1/ATP6V0D1/DYNC1LI1/VAMP3/STX7/DYNC1H1/THBS3/HLA-DQA1/TUBA3E/STX18/DYNC2H1/HGS/EEA1/ATP6V0E1/ITGB3/RAB7A/RAB5C/RAB5A/ATP6V1H/HLA-DRB1/SEC61A1/ITGB2/DYNC1LI2/SEC61B/NCF2/TUBB2A/ATP6V1C1/HLA-DQB1/TCIRG1/DYNC1I2/ATP6V1G1/RILP/COLEC11/ATP6AP1/SCARB1/CLEC4M/FCGR1A/FCGR2A/TLR4/RAB5B/MRC2/CD36/ATP6V0B/CD14/HLA-DOA/ITGA2/ATP6V1B2/PIK3C3/ITGB1/THBS2/ITGAM/TLR2/CYBB/CORO1A/PIKFYVE/MARCO/SEC61A2/TUBB2B/TUBA3D/CYBA/ATP6V1E2/SEC61G/TUBA4A/ATP6V1G2/TLR6/COMP/HLA-DRB5/OLR1	8.36938050114736
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	125/2914	224/9376	1.79551916854594	HLA-B/HLA-E/HLA-A/B2M/CHEK2/IL15/HLA-C/HLA-DPB1/HLA-DQA2/HLA-DRA/IL15RA/IL1R1/PIK3R1/AKT3/TNFRSF1A/HLA-F/ADCY1/HLA-DPA1/PRKACB/HLA-DMB/RELB/TGFBR1/TSPO/CREB3/CREB3L2/HLA-DMA/TLN2/JAK1/TGFBR2/HLA-DQA1/CREB3L1/ETS2/BCL2L1/ETS1/ANAPC13/CDKN2B/CREBBP/RELA/PPP3CC/PPP3CB/RB1/TLN1/JUN/ADCY3/CDC27/LTBR/CDK4/IKBKG/XIAP/ANAPC7/PIK3CA/STAT5B/SMAD2/NFATC4/HLA-DRB1/ITGB2/AKT2/MMP7/MAPK1/ATF2/ATF6B/IKBKB/MAP3K3/CREB5/MAPK10/CREB1/ELK4/NFKB2/SPI1/PRKACA/NFKB1/HLA-DQB1/MAP2K1/MAPK8/MAD1L1/SMAD4/MAP2K2/KRAS/CDC26/SMAD3/CRTC1/VAC14/IL1R2/ADCY7/NRP1/KAT5/TGFB2/CCND2/ATM/CD40/GPS2/HLA-DOA/RANBP3/CD4/CDKN2C/PIK3CD/IL2RA/MAP2K4/ELK1/ATR/CHUK/IL2RG/CDKN1A/FOSL1/ICAM1/MYC/ITGAL/STAT5A/SRF/NFATC3/CRTC2/ADCY9/TBP/KAT2B/ZFP36/JAK3/TGFB3/TRRAP/ANAPC2/NFATC2/ADCY6/CD3E/PIK3R2/HLA-DRB5/NFATC1	8.09214371637735
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	135/2914	250/9376	1.73748798901853	RAB31/HLA-B/HLA-E/HLA-A/PDGFRA/ARFGAP3/PIP5K1C/HLA-C/SMAP1/GRK5/IGF1R/CLTB/PSD3/HLA-F/EHD2/PLD1/RAB22A/TGFBR1/CYTH2/KIF5B/VPS37A/EGFR/CAV2/TGFBR2/AP2M1/RUFY2/SNX1/ASAP2/IGF2R/STAM/CAPZA2/ZFYVE16/RABEP1/AGAP3/VPS26B/SRC/RAB11B/ARF1/SMAP2/STAM2/GIT2/RAB11FIP2/CHMP3/PSD/HGS/RUFY1/BIN1/PDCD6IP/WASL/EEA1/PML/CHMP4A/RAB7A/RAB5C/EPN2/RAB5A/VPS4B/SH3KBP1/SMAD2/VPS26A/SNF8/ACAP1/CLTC/CHMP1B/IST1/ARF5/VPS28/RNF41/VPS4A/CAPZB/CHMP4B/USP8/SH3GLB1/ARAP1/TSG101/ARFGAP2/WIPF1/CHMP1A/ARFGEF1/GRK4/RAB4A/STAMBP/CHMP6/CXCR4/ACAP2/SMAD3/CHMP7/PRKCI/SPG21/EHD1/KIF5A/RAB5B/ZFYVE27/WIPF3/EHD4/SNX12/GBF1/ACAP3/DNM1/RAB35/SMURF2/AMPH/ARF4/CHMP5/ARAP2/VPS45/GRK6/WWP1/CYTH4/ARRB2/TRAF6/PARD6G/ZFYVE9/IL2RA/CYTH1/IL2RG/RHOA/IQSEC2/SNX6/VPS37C/FOLR2/RAB11FIP3/ARRB1/HSPA1A/ARFGAP1/CAV1/AP2S1/CLTCL1/PIP5K1B/ARPC2/ARAP3/HSPA6/KIF5C/PARD6A/VPS37D	7.93654821267442
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	70/2914	112/9376	2.01098146877145	IFNGR2/HLA-DPB1/LAMA4/HLA-DQA2/HLA-DRA/AKT3/STAT1/MAPK14/TNFRSF1A/STAT3/HLA-DPA1/LAMB2/GNAI2/IFNGR1/HLA-DMB/MYD88/HLA-DMA/BCL2/JAK1/HLA-DQA1/BCL2L1/LAMC1/RELA/BIRC2/SOCS1/IKBKG/XIAP/PDPK1/LY96/HLA-DRB1/AKT2/MAPK1/IKBKB/MAPK10/ALOX5/NFKB1/HLA-DQB1/MAPK8/IRAK1/MAP3K7/JAK2/LAMA3/IRAK4/BAD/TGFB2/TLR4/CD40/BIRC3/GNAO1/HLA-DOA/TAB2/MAP2K3/TRAF6/ITGB1/CIITA/TLR2/CHUK/LAMB1/PIK3R5/IL10/HSPA1A/LAMC3/LAMB3/HSPA6/MAPK12/TGFB3/MAPK11/TYK2/PIK3CG/HLA-DRB5	7.22769584408787
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	61/2914	93/9376	2.11044936937735	IFNGR2/HLA-DPB1/HLA-DQA2/HLA-DRA/STAT1/MAPK14/HLA-DPA1/MAF/IFNGR1/HLA-DMB/IL4R/HLA-DMA/JAK1/HLA-DQA1/RELA/RBPJ/PPP3CC/PPP3CB/JUN/DLL1/IKBKG/MAML2/STAT5B/HLA-DRB1/MAPK1/IKBKB/MAPK10/NFKB1/HLA-DQB1/MAPK8/STAT6/JAK2/NOTCH1/NOTCH2/MAML1/HLA-DOA/CD4/IL2RA/CHUK/NFKBIE/IL2RG/RUNX3/MAML3/PLCG1/IL12RB1/NOTCH3/STAT5A/NFATC3/JAK3/LAT/MAPK12/MAPK11/TYK2/CD247/NFATC2/CD3E/STAT4/ZAP70/JAG1/HLA-DRB5/NFATC1	7.22674941431377
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	100/2914	181/9376	1.77766317681454	SPHK1/C3/CTSS/IFNGR2/CTSD/HLA-DPB1/HLA-DQA2/HLA-DRA/AKT3/STAT1/MAPK14/TNFRSF1A/CALM2/PLA2R1/HLA-DPA1/FADD/LAMP1/IFNGR1/HLA-DMB/TRADD/FCGR3A/LSP1/LAMP2/MYD88/HLA-DMA/BCL2/ATP6V0A1/ATP6V0D1/JAK1/CD74/CARD9/HLA-DQA1/PLK3/CREBBP/RELA/PPP3CC/PPP3CB/SRC/EEA1/ARHGEF12/RAB7A/RAB5C/RAB5A/ATP6V1H/HLA-DRB1/ITGB2/MALT1/AKT2/MAPK1/RAF1/IL18/MAPK10/CREB1/NFKB1/HLA-DQB1/MAPK8/TCIRG1/IRAK1/ATP6AP1/BID/CLEC4M/SYK/JAK2/FCGR1A/IRAK4/BAD/CAMP/FCGR2A/TGFB2/TLR4/RAB5B/MRC2/VDR/ATP6V0B/RIPK2/CD14/CR1/TLR1/HLA-DOA/CAMK2D/TRAF6/PIK3C3/CIITA/ITGAM/ITGAX/TLR2/SPHK2/FCER1G/RHOA/RFX5/IL10/CEBPB/CORO1A/CASP10/MAPK12/TGFB3/MAPK11/TLR6/RFXAP/HLA-DRB5	7.09417489149
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	110/2914	205/9376	1.72650116343305	CD44/HLA-B/HLA-E/HLA-A/VIM/B2M/GADD45G/HLA-C/HLA-DPB1/HLA-DQA2/HLA-DRA/PIK3R1/AKT3/STAT1/MAPK14/IFNAR1/STAT3/HLA-F/NCOR2/HLA-DPA1/LYN/FADD/HLA-DMB/TRADD/RELB/FAS/TAP1/MYD88/HLA-DMA/BCL2/JAK1/HLA-DQA1/POLK/TAPBPL/TAPBP/RELA/RBPJ/CD58/STAT2/RB1/SAP30/PSMD3/PSMC2/JUN/OAS1/CDK4/IKBKG/EIF2AK2/SAP30L/OAS2/PIK3CA/HLA-DRB1/AKT2/IKBKB/MAPK10/NFKB2/NFKB1/HLA-DQB1/MAPK8/CDKN1B/IRAK1/PSMC6/SNW1/BID/MAP3K7/ENTPD3/PSMC5/SYK/TRAF3/IRAK4/CCND2/CD40/CXCL10/MAP2K7/IRF7/MAVS/HLA-DOA/TAB2/BCL2L11/RIPK1/IRF9/MAP2K3/TRAF6/DDB2/BTK/TRAF5/PIK3CD/MAP2K4/TLR2/CHUK/NFKBIE/CDKN1A/RUNX3/ICAM1/MYC/SIN3A/ITGAL/HES1/IKBKE/GADD45A/JAK3/PLCG2/GADD45B/MAPK12/MAPK11/TYK2/CD247/CD3E/PIK3R2/HLA-DRB5	7.06239221909677
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	160/2914	333/9376	1.54597974776424	ITGB5/FOXO1/WNT4/VEGFA/HLA-B/HLA-E/HLA-A/ITGB8/PDGFRB/TNXB/HLA-C/THBS1/RHEB/LAMA4/WNT5A/PIK3R1/AKT3/STAT1/IFNAR1/TNFRSF1A/TADA3/ATP6V1D/LFNG/HLA-F/ITGAV/COL4A4/LAMB2/PRKACB/WNT5B/SPP1/FADD/MX2/TRADD/VTN/RFNG/MAGI1/HES4/CREB3/FAS/CREB3L2/ATP6V0A1/ATP6V0D1/JAK1/MX1/EGFR/PPP2R3C/THBS3/CREB3L1/LAMC1/CREBBP/RELA/RBPJ/WNT9A/STAT2/RB1/PPP2R5E/COL6A3/TNC/CDK4/IKBKG/EIF2AK2/ATP6V0E1/WNT2/ITGB3/MAML2/PIK3CA/ATP6V1H/APC/UBE3A/RBL2/PPP2R5B/PTK2/AKT2/MAPK1/RAF1/PPP2CA/CHD4/IKBKB/CREB5/CREB1/WNT6/FZD2/ATP6V1C1/PRKACA/NFKB1/ITGA3/MAP2K1/TCIRG1/ATP6V1G1/CDKN1B/PPP2CB/MAP2K2/ATP6AP1/TCF7L2/KRAS/PPP2R2D/PTGER4/ITGA1/RPS6KB1/UBR4/PRKCI/HES6/TRAF3/LAMA3/NOTCH1/BAD/DVL2/SOS2/CCND2/ATM/CSNK1A1/ATP6V0B/NOTCH2/PSEN1/MAML1/OASL/NFX1/ITGA2/COL4A3/IRF9/PPP2R3A/ATP6V1B2/PARD6G/TUBG2/ITGB1/COL4A6/PIK3CD/THBS2/ATR/CHUK/LAMB1/CDKN1A/TICAM1/FZD3/WNT3/MAML3/ITGA4/NOTCH3/MFNG/TBP/HES1/LAMC3/LAMB3/DLG3/FZD10/IKBKE/MTOR/NOTCH4/TSC2/FZD4/FZD1/ATP6V1E2/TYK2/HEYL/PARD6A/ATP6V1G2/FZD8/COMP/PIK3R2/JAG1	6.81223027328051
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	107/2914	204/9376	1.68764719340035	SDC2/ITGB5/CD44/WNT4/VEGFA/TIMP3/DCN/LUM/CD63/ACTG1/MRAS/ESR1/RRAS/THBS1/ROCK2/MSN/WNT5A/PIK3R1/AKT3/MAPK14/IGF1R/STAT3/ITGAV/PLAU/PLAUR/TWIST1/PRKACB/FGF2/WNT5B/FLNA/VTN/FAS/MMP2/EGFR/CAV2/TWIST2/PTPN11/WNT9A/PRKCA/SRC/RRAS2/KDR/WNT2/ITGB3/HSPB2/ARHGEF12/PDPK1/PIK3CA/SMAD2/HIF1A/PTK2/CTTN/AKT2/MAPK1/RAF1/ITPR2/WNT6/FZD2/PRKACA/MAP2K1/ARAF/MAP2K2/KRAS/NUDT16L1/RPS6KB1/PPP1R12A/FRS2/TGFB2/SOS2/TLR4/ARHGEF1/MMP9/HOXD10/ROCK1/HPSE/ITGA2/PPP1R12B/CAMK2D/VAV1/IGF1/DDX5/ITGB1/PIK3CD/ELK1/TLR2/CDKN1A/RHOA/FZD3/WNT3/PTCH1/MYC/SMO/PLCG1/HBEGF/PLCE1/FZD10/MTOR/CAV1/PTPN6/FZD4/PLCG2/FZD1/MAPK12/MAPK11/ANK2/FZD8/PIK3R2	6.66800121879921
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	79/2914	138/9376	1.84194244675878	ACTG1/PIP5K1C/PKN1/ROCK2/PIK3R1/AKT3/MAPK14/RPS6KA3/MYD88/BCAR1/RELA/RHOG/SRC/GIT2/CASP1/JUN/WASL/WASF2/IKBKG/LIMK1/ARHGEF12/PIK3CA/PTK2/AKT2/CRK/MAPK1/IL18/IKBKB/MAPK10/NFKB1/MAP2K1/MAPK8/IRAK1/MAP2K2/WIPF1/MAP3K7/PYCARD/PKN2/LCP2/IRAK4/FCGR2A/TLR4/ARHGEF1/WIPF3/ROCK1/MAP2K7/GNAQ/BAIAP2/CD4/TAB2/ARHGEF7/VAV1/MAP2K3/TRAF6/ITGB1/RAC2/PIK3CD/MAP2K4/DOCK1/CHUK/WAS/TICAM1/RHOA/ELMO2/RPS6KA2/ITGA4/IL10/PLCG1/NFATC3/ARHGEF28/PIP5K1B/ARPC2/LAT/MAPK12/MAPK11/NFATC2/PIK3R2/ZAP70/NFATC1	6.69082859746501
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	66/2914	109/9376	1.9482536064428	IFNGR2/HLA-DPB1/HLA-DQA2/HLA-DRA/IL1R1/STAT1/MAPK14/STAT3/HLA-DPA1/IFNGR1/HLA-DMB/TGFBR1/IL6ST/IL4R/HLA-DMA/JAK1/TGFBR2/HLA-DQA1/RELA/PPP3CC/PPP3CB/JUN/IKBKG/RARA/STAT5B/SMAD2/HIF1A/IL6R/HLA-DRB1/MAPK1/IKBKB/MAPK10/NFKB1/RORA/HLA-DQB1/MAPK8/SMAD4/RXRB/SMAD3/STAT6/JAK2/RUNX1/HLA-DOA/CD4/AHR/IL2RA/CHUK/NFKBIE/IL2RG/PLCG1/IL27RA/IL12RB1/STAT5A/NFATC3/MTOR/JAK3/LAT/MAPK12/MAPK11/TYK2/CD247/NFATC2/CD3E/ZAP70/HLA-DRB5/NFATC1	6.68675029667053
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	105/2914	203/9376	1.66426052587982	ITGB5/ZYX/EMP1/RAP1B/VEGFA/MYL9/ACTG1/PDGFRA/ITGB8/PDGFRB/FYN/PDGFD/PIP5K1C/CAPN2/TNXB/THBS1/ROCK2/LAMA4/PIK3R1/AKT3/IGF1R/ITGAV/COL4A4/LAMB2/PARVA/SPP1/FLNA/VTN/VCL/BCL2/MYLK/TLN2/RAP1A/ILK/EGFR/CAV2/THBS3/PAK3/LAMC1/BCAR1/PRKCA/SRC/BIRC2/TLN1/VEGFB/SHC2/JUN/KDR/COL6A3/PDGFC/TNC/PARVB/XIAP/ITGB3/PDPK1/PIK3CA/ARHGAP5/PTK2/AKT2/CRK/MAPK1/RAF1/MAPK10/SHC1/ITGA3/MAP2K1/MAPK8/ARHGAP35/MYL5/ITGA1/PPP1R12A/VEGFC/LAMA3/BAD/SOS2/CCND2/BIRC3/EMP2/ROCK1/PARVG/ITGA2/PPP1R12B/COL4A3/VAV1/IGF1/PAK2/ITGB1/RAC2/COL4A6/PIK3CD/THBS2/ELK1/DOCK1/LAMB1/PDGFA/RHOA/ITGA4/MYL12B/LAMC3/LAMB3/CAV1/PIP5K1B/SHC3/COMP/PIK3R2	6.42506761309864
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	79/2914	142/9376	1.79005674403318	CTSK/IFNGR2/FYN/IL1R1/PIK3R1/AKT3/STAT1/MAPK14/IFNAR1/TNFRSF1A/FOSL2/IFNGR1/RELB/TGFBR1/FCGR3A/TREM2/JAK1/MITF/TGFBR2/RELA/ATP2A2/PPP3CC/STAT2/PPP3CB/CYLD/JUN/SOCS1/IKBKG/LILRB4/ITGB3/PIK3CA/AKT2/MAPK1/IKBKB/NCF2/ITPR2/CSF1/MAPK10/CREB1/SIRPA/NFKB2/SPI1/NFKB1/MAP2K1/MAPK8/OSCAR/TNFRSF11B/MAP3K7/ACP5/SYK/LCP2/GAB2/FCGR1A/JUND/FCGR2A/TYROBP/TGFB2/SQSTM1/MAP2K7/TAB2/IRF9/TRAF6/SOCS3/BTK/LILRB2/PIK3CD/CHUK/LILRB1/FOSL1/LILRB3/CYBA/PLCG2/MAPK12/LILRB5/MAPK11/TYK2/NFATC2/PIK3R2/NFATC1	6.37022037445417
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	50/2914	78/9376	2.06254509617584	C3/IFNGR2/MARCKSL1/HLA-DPB1/HLA-DQA2/HLA-DRA/STAT1/MAPK14/HLA-DPA1/IFNGR1/HLA-DMB/FCGR3A/MYD88/HLA-DMA/JAK1/HLA-DQA1/EEF1A1/RELA/JUN/HLA-DRB1/ITGB2/MAPK1/NCF2/NFKB1/HLA-DQB1/IRAK1/MAP3K7/JAK2/FCGR1A/IRAK4/FCGR2A/TGFB2/TLR4/CR1/HLA-DOA/TAB2/TRAF6/ITGB1/ITGAM/ELK1/TLR2/CYBB/ITGA4/IL10/PTPN6/CYBA/MAPK12/TGFB3/MAPK11/HLA-DRB5	6.32771392856041
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	87/2914	163/9376	1.71735349971157	PIK3R1/AKT3/STAT1/MAPK14/IFNAR1/STAT3/FADD/TGFBR1/CREB3/FAS/CREB3L2/MYD88/BCL2/JAK1/TGFBR2/CREB3L1/CREBBP/RELA/PRKCA/STAT2/RB1/SRC/JUN/IKBKG/PIK3CA/STAT5B/NFATC4/AKT2/MAPK1/ATF2/RAF1/ATF6B/IKBKB/YWHAQ/CREB5/MAPK10/CREB1/NFKB1/MAP2K1/MAPK8/IRAK1/SMAD4/ARAF/MAP2K2/ATP6AP1/KRAS/BID/MAP3K7/SMAD3/STAT6/TRAF3/JAK2/IRAK4/BAD/TGFB2/SOS2/TLR4/MMP9/MAP2K7/IRF7/MAVS/TAB2/MAP2K3/TRAF6/DDB2/PIK3CD/MAP2K4/ELK1/TLR2/CHUK/CDKN1A/IFIH1/TICAM1/MYC/STAT5A/NFATC3/IKBKE/CASP10/JAK3/MAPK12/TGFB3/MAPK11/TYK2/NFATC2/STAT4/PIK3R2/NFATC1	6.20402334170276
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	94/2914	180/9376	1.68028673835125	C3/HLA-B/HLA-E/HLA-A/B2M/IFNGR2/DAXX/HLA-C/HLA-DPB1/RHEB/HLA-DQA2/HLA-DRA/PIK3R1/AKT3/STAT1/IFNAR1/TNFRSF1A/HLA-F/HLA-DPA1/FADD/IFNGR1/HLA-DMB/TRADD/FAS/TAP1/MYD88/HLA-DMA/BCL2/JAK1/CD74/PILRA/TNFRSF14/CARD9/HLA-DQA1/BCL2L1/TAPBPL/TAPBP/SP100/PTPN11/RELA/HCFC2/STAT2/SRC/BIRC2/RNASEL/OAS1/IKBKG/EIF2AK2/OAS2/ITGB3/PML/PIK3CA/HLA-DRB1/AKT2/IKBKB/EIF2B3/NFKB1/HLA-DQB1/IRAK1/BID/MAP3K7/SYK/SRSF4/TRAF3/JAK2/IRAK4/BAD/EIF2B1/BIRC3/EIF2B4/IRF7/MAVS/HLA-DOA/TAB2/IRF9/TRAF6/SOCS3/TRAF5/PIK3CD/TLR2/CHUK/IFIH1/POU2F2/TICAM1/BST2/TNFSF14/IKBKE/MTOR/TSC2/TYK2/C5/PIK3R2/HLA-DRB5/CCL5	6.18836200705313
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	61/2914	103/9376	1.90555137235042	C3/IFNGR2/SERPINE1/ACE/PIK3R1/CFLAR/AKT3/MAPK14/TNFRSF1A/ADCY1/GNAI2/C1QB/FADD/IFNGR1/BDKRB2/TGFBR1/C1QA/FAS/MYD88/TGFBR2/RELA/JUN/IKBKG/C1QC/PIK3CA/SMAD2/AKT2/MAPK1/PPP2CA/IKBKB/MAPK10/NFKB1/MAPK8/IRAK1/PPP2CB/PPP2R2D/GNA11/IRAK4/TGFB2/TLR4/GNAO1/GNAQ/GNA15/TRAF6/PIK3CD/MAP2K4/TLR2/CHUK/TICAM1/IL10/PLCB2/MAPK12/TGFB3/MAPK11/CD247/TLR6/GNA14/CD3E/PIK3R2/GNAL/CCL5	6.20538184311456
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	74/2914	133/9376	1.79022711204917	FOXO1/IRS2/GADD45G/HOMER3/IRS1/PIK3R1/AKT3/MAPK14/IGF1R/STAT3/GABARAPL1/GABARAP/INSR/SETD7/TGFBR1/FBXO32/CAT/EGFR/TGFBR2/SOD2/PLK3/CDKN2B/CREBBP/GABARAPL2/CSNK1E/PRKAG1/PRKAG2/PDPK1/PIK3CA/PRKAA1/RBL2/AKT2/MAPK1/RAF1/IKBKB/MAPK10/MAP2K1/MAPK8/CDKN1B/STK11/SMAD4/SGK1/ARAF/MAP2K2/KRAS/G6PC3/SMAD3/STK4/CCNG2/TGFB2/SOS2/CCND2/ATM/SGK3/FBXO25/CDKN2D/BCL2L11/IGF1/PIK3CD/CHUK/FOXO3/HOMER2/CDKN1A/PRKAB1/IL10/S1PR4/GADD45A/GADD45B/MAPK12/TGFB3/MAPK11/NLK/PIK3R2/PRKAA2	6.16336950063263
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	84/2914	157/9376	1.72150260766167	SPHK1/AXL/ITGB5/MFGE8/THBS1/PROS1/MAPK14/ITGAV/ATP8A2/C1QB/MAPKAPK2/LIPA/C1QA/ABCA1/TMEM30A/NR1H2/ADAM10/BCAR1/PTPN11/ATP2A2/VPS41/GAS6/RAB14/CASP1/VPS16/HAVCR2/ADAM9/ITGB3/C1QC/PLA2G15/RAB7A/RAB5C/RAB5A/HIF1A/NFATC4/PTK2/CRK/MAPK1/LRP1/CREB1/SIRPA/ALOX5/MAP2K1/SGK1/MAP2K2/CPT1C/ATP11B/NR1H3/PTGER4/JAK2/RAB5B/CD36/VPS18/PBX1/PANX1/CAMK2D/XKR8/EPOR/DUSP7/DOCK1/SPHK2/VPS8/ATP11C/IL10/VPS39/TGFBRAP1/CEBPB/NFATC3/SIGLEC10/DUSP2/VPS11/CPT1A/PTGER2/PTPN6/MERTK/DUSP8/TYRO3/MAPK12/MAPK11/NFATC2/CX3CR1/XKR6/GPR132/NFATC1	6.1219920157188
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	55/2914	90/9376	1.96629299168764	IFNGR2/PIK3R1/AKT3/STAT1/MAPK14/STAT3/IFNGR1/MYD88/JAK1/EGFR/PTPN11/RELA/PPP3CC/PPP3CB/JUN/IKBKG/PIK3CA/HIF1A/CSNK2A1/AKT2/MAPK1/RAF1/IKBKB/MAP3K3/NFKB1/MAP2K1/MAP2K2/KRAS/RPS6KB1/JAK2/TLR4/CD4/MAP2K3/TRAF6/PIK3CD/TLR2/CHUK/NFKBIE/TICAM1/PLCG1/NFATC3/BATF3/MTOR/PTPN6/LAT/BATF/MAPK12/MAPK11/CD247/BATF2/NFATC2/CD3E/PIK3R2/ZAP70/NFATC1	6.18532721929489
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	72/2914	130/9376	1.78203896309593	GNG4/VEGFA/PIK3R1/AKT3/MAPK14/COL4A4/ADCY1/PRKACB/GNAI2/TGFBR1/GNG11/CREB3/RXFP1/MMP2/CREB3L2/EGFR/EDNRB/TGFBR2/GNB5/CREB3L1/RELA/PRKCA/SRC/VEGFB/SHC2/JUN/ADCY3/GNB2/PIK3CA/SMAD2/AKT2/MAPK1/ATF2/RAF1/ATF6B/CREB5/MAPK10/CREB1/PRKACA/NFKB1/SHC1/MAP2K1/MAPK8/GNB1/GNG2/MAP2K2/KRAS/VEGFC/ADCY7/SOS2/MMP1/MMP9/GNAO1/GNB4/MAP2K7/GNA15/COL4A3/ARRB2/COL4A6/PIK3CD/MAP2K4/ACTA2/PLCB2/ARRB1/ADCY9/GNGT2/MAPK12/MAPK11/SHC3/ADCY6/GNB3/PIK3R2	6.02934392991778
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	99/2914	196/9376	1.62520135027244	CLEC2B/GNG4/C3/VEGFA/HLA-B/HLA-E/HLA-A/HLA-C/PIK3R1/AKT3/STAT1/MAPK14/IFNAR1/TNFRSF1A/CALM2/STAT3/HLA-F/MAP1LC3A/LYN/FGF2/FADD/MAPKAPK2/IFNGR1/TRADD/IL6ST/GNG11/FAS/JAK1/GNB5/CREBBP/RELA/PPP3CC/STAT2/BECN1/PPP3CB/RB1/SRC/MICA/JUN/CDK4/IKBKG/EIF2AK2/GNB2/PIK3CA/HIF1A/NFATC4/CD86/AKT2/MAPK1/RAF1/IKBKB/ITPR2/MAPK10/CREB1/NFKB1/MAP2K1/MAPK8/GNB1/GNG2/MAP2K2/TCF7L2/KRAS/BID/SYK/TRAF3/JAK2/GNB4/MAP2K7/IRF7/IRF9/ATG14/MAP1LC3B/PIK3C3/PIK3CD/MAP2K4/CHUK/CDKN1A/TICAM1/HCK/PIK3R5/ICAM1/MYC/PLCG1/NFATC3/MICB/ZFP36/IKBKE/MTOR/PLCG2/GNGT2/ANGPT2/MAPK12/MAPK11/TYK2/PIK3CG/NFATC2/GNB3/PIK3R2/NFATC1	5.93982346193704
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	139/2914	300/9376	1.4908075955159	RASGRP2/MAP3K5/RAP1B/VEGFA/GADD45G/PDGFRA/MRAS/DAXX/PDGFRB/PDGFD/RRAS/IL1R1/AKT3/MAPK14/IGF1R/MAPK7/TNFRSF1A/INSR/PRKACB/FGF2/CACNB3/MAP4K4/MAPKAPK2/FLNA/TRADD/RELB/RPS6KA3/TGFBR1/MAP3K4/FAS/FGF7/NTRK1/DUSP1/MYD88/RAP1A/EGFR/TGFBR2/CDC25B/CACNA2D1/RELA/MAP3K2/PRKCA/PPP3CC/PPP3CB/TAOK1/RRAS2/VEGFB/CACNB2/JUN/MAX/KDR/PDGFC/IKBKG/MAPKAPK3/DUSP3/AKT2/CRK/MAPK1/ATF2/RAF1/IKBKB/MAP3K3/CSF1/MAPK10/ELK4/NFKB2/PRKACA/NFKB1/MAP2K1/MAPK8/IRAK1/EFNA5/ARAF/MAP2K2/KRAS/MAP3K7/MAP4K3/MAP3K13/STK4/PPM1A/RASA2/VEGFC/IRAK4/JUND/TGFB2/SOS2/MAP2K7/CD14/TAB2/CACNA1G/ARRB2/IGF1/PAK2/MAP2K3/MAP2K5/TRAF6/RAC2/TAOK2/DUSP7/FLT3LG/MAP2K4/ELK1/PTPN7/HSPB1/CHUK/NTRK2/PDGFA/MAPK8IP1/MEF2C/DUSP10/FGF10/RPS6KA2/MAP3K10/MYC/CACNA2D4/SRF/NFATC3/ARRB1/DUSP2/CACNB1/HSPA1A/EPHA2/CACNA1C/GADD45A/DUSP8/RASGRP3/HSPA6/TEK/MAP3K12/GADD45B/CACNA1H/ANGPT2/PTPN5/MAPK12/TGFB3/MAPK11/NLK/CACNA1A/NFATC1	5.80191809841363
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	93/2914	184/9376	1.62627197039778	DPYSL2/CFL2/WNT4/ABLIM1/TRPC4/MYL9/FYN/SEMA3C/RRAS/ROCK2/WNT5A/PIK3R1/CXCL12/UNC5B/PLXNA4/ABL1/GNAI2/WNT5B/TRPC6/NCK1/ILK/ABLIM3/BMPR2/RHOD/PAK3/PTPN11/PRKCA/PPP3CC/PPP3CB/SRC/PLXNB2/LIMK1/ARHGEF12/PDPK1/SSH1/PLXNC1/PIK3CA/NFATC4/PTK2/MAPK1/BOC/RAF1/SRGAP1/CDK5/EFNA5/KRAS/MYL5/SEMA6C/CXCR4/RYK/NEO1/EFNB1/NRP1/NTN4/ROCK1/CFL1/NCK2/RGMA/CAMK2D/GDF7/PAK2/PARD6G/ITGB1/RAC2/PIK3CD/LRIG2/PLXNB1/ABLIM2/SEMA4D/RHOA/FZD3/PTCH1/SLIT3/SMO/PLCG1/RGS3/MYL12B/ENAH/NFATC3/PLXNA1/TRPC1/EPHA2/EPHB6/EFNB2/ROBO2/PLCG2/EPHB2/SRGAP3/SEMA4A/PARD6A/NFATC2/PIK3R2/EPHA6	5.76121142778457
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	110/2914	227/9376	1.559175059488	GNG4/VEGFA/HLA-B/HLA-E/HLA-A/B2M/PDGFRA/AKAP13/HLA-C/ROCK2/RHEB/IL1R1/PIK3R1/AKT3/MAPK14/TNFRSF1A/CALM2/STAT3/HLA-F/ITGAV/ADCY1/CXCL12/PRKACB/GNAI2/FADD/TRADD/GNG11/CREB3/FAS/TAP1/CREB3L2/JAK1/EGFR/GNB5/CREB3L1/TAPBPL/TAPBP/BCAR1/RELA/PRKCA/PPP3CC/PPP3CB/RB1/SRC/ADCY3/GNA13/CDK4/IKBKG/ITGB3/GNB2/ARHGEF12/PIK3CA/IL6R/NFATC4/PTK2/AKT2/CRK/MAPK1/ATF2/RAF1/ATF6B/IKBKB/ITPR2/CREB5/CREB1/PRKACA/NFKB1/MAP2K1/GNB1/GNG2/MAP2K2/KRAS/BID/PTGER4/CXCR4/GNA11/RPS6KB1/ADCY7/SOS2/ARHGEF1/GNAO1/GNB4/ROCK1/GNAQ/RIPK1/RAC2/TRAF5/PIK3CD/ELK1/CHUK/ARHGEF11/CDKN1A/RHOA/SP1/MYC/PLCB2/NFATC3/ADCY9/MTOR/TSC2/PTGER2/GNGT2/MAPK12/MAPK11/NFATC2/ADCY6/GNB3/PIK3R2/CCL5/NFATC1	5.72691638751771
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	66/2914	119/9376	1.78453481598542	MAP3K5/IL15/TNFRSF1B/PIK3R1/CFLAR/AKT3/MAPK14/VCAM1/TNFRSF1A/FADD/TRADD/CREB3/FAS/CREB3L2/MMP14/RHBDF1/CREB3L1/RELA/BIRC2/CYLD/JUN/IKBKG/XIAP/PIK3CA/AKT2/MAPK1/ATF2/ATF6B/IKBKB/CSF1/CREB5/MAPK10/CREB1/NFKB1/MAP2K1/MAPK8/MAP3K7/BCL3/VEGFC/TRAF3/MMP9/CXCL10/BIRC3/MLKL/MAP2K7/TAB2/RIPK1/MAP2K3/SOCS3/TRAF5/PIK3CD/MAP2K4/CHUK/ICAM1/CEBPB/IL18R1/MMP3/CASP10/TAB3/MAPK12/MAPK11/TRAF1/PIK3R2/LIF/JAG1/CCL5	5.78359009560722
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	68/2914	125/9376	1.75035827041867	SPHK1/MAP3K5/SPTLC2/CERS6/FYN/CTSD/S1PR3/ROCK2/SPTSSA/PIK3R1/AKT3/MAPK14/TNFRSF1A/PLD1/GNAI2/TRADD/BDKRB2/DEGS1/CERS4/BCL2/ORMDL1/PPP2R3C/CERS2/ASAH1/RELA/SMPD1/SGPL1/PRKCA/PPP2R5E/ORMDL2/GNA13/SPTLC1/PDPK1/PIK3CA/ADORA1/PPP2R5B/AKT2/MAPK1/RAF1/PPP2CA/MAPK10/NFKB1/MAP2K1/MAPK8/PPP2CB/MAP2K2/KRAS/BID/PPP2R2D/SGMS1/GAB2/SGMS2/NSMAF/ABCC1/ROCK1/GNAQ/PPP2R3A/RAC2/PIK3CD/ORMDL3/SPHK2/FCER1G/RHOA/PLCB2/S1PR4/MAPK12/MAPK11/PIK3R2	5.67121712530229
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	47/2914	77/9376	1.96397151235861	VEGFA/GADD45G/PIK3R1/AKT3/STAT1/STAT3/PLD1/TGFBR1/JAK1/EGFR/TGFBR2/POLK/BCL2L1/RELA/RB1/CDK4/IKBKG/PIK3CA/SMAD2/AKT2/RALA/MAPK1/RAF1/IKBKB/MAPK10/NFKB1/MAP2K1/MAPK8/SMAD4/ARAF/KRAS/SMAD3/RPS6KB1/BAD/TGFB2/RALGDS/DDB2/RAC2/PIK3CD/ARHGEF6/CHUK/CDKN1A/MTOR/GADD45A/GADD45B/TGFB3/PIK3R2	5.70345965074979
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	47/2914	77/9376	1.96397151235861	GADD45G/PIK3R1/AKT3/ABL1/TGFBR1/TGFBR2/POLK/BCL2L1/PTPN11/RELA/CTBP2/RB1/SHC2/CDK4/IKBKG/PIK3CA/STAT5B/AKT2/CRK/MAPK1/RAF1/IKBKB/NFKB1/SHC1/MAP2K1/CDKN1B/SMAD4/ARAF/MAP2K2/KRAS/SMAD3/GAB2/BAD/TGFB2/SOS2/RUNX1/DDB2/PIK3CD/CHUK/CDKN1A/MYC/STAT5A/GADD45A/GADD45B/TGFB3/SHC3/PIK3R2	5.70345965074979
NA	NA	hsa04518	Integrin signaling	79/2914	154/9376	1.65057180293968	C3/FBN1/ITGB5/VEGFA/ACTG1/PDGFRA/ITGB8/PDGFRB/PDGFD/TNXB/THBS1/FERMT2/LAMA4/PIK3R1/AKT3/IGF1R/VCAM1/ITGAV/COL4A4/LAMB2/PARVA/SPP1/FLNA/VTN/FERMT3/LIMS2/VCL/TLN2/ILK/EGFR/THBS3/ITGAE/LIMS1/LAMC1/SRC/TLN1/VEGFB/KDR/COL6A3/PDGFC/TNC/PARVB/ITGB3/ICAM2/PIK3CA/ITGB2/PTK2/AKT2/ITGA3/ITGA1/VEGFC/LAMA3/CCND2/NCK2/PARVG/ITGA2/COL4A3/IGF1/ITGB1/RAC2/COL4A6/PIK3CD/ARHGEF6/THBS2/ITGAM/ITGAX/LAMB1/PDGFA/ICAM1/ITGA4/ITGAL/FGG/LAMC3/LAMB3/FREM1/MTOR/ITGAD/COMP/PIK3R2	5.46625607144649
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	56/2914	99/9376	1.82003979395881	NCOR1/ESR1/PIK3R1/AKT3/MAPK14/IGF1R/ADCY1/PRKACB/MMP2/BCL2/EGFR/RB1/SRC/SHC2/JUN/ADCY3/DLL1/CDK4/PIK3CA/PTK2/AKT2/MAPK1/RAF1/MAPK10/PRKACA/SHC1/MAP2K1/MAPK8/CDKN1B/ARAF/MAP2K2/KRAS/RPS6KB1/NOTCH1/BAD/ADCY7/SOS2/MMP9/NOTCH2/MED1/IGF1/CDKN2C/PIK3CD/CDKN1A/SP1/NOTCH3/HBEGF/ADCY9/MTOR/NOTCH4/MAPK12/MAPK11/SHC3/ADCY6/PIK3R2/JAG1	5.50802219891303
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	102/2914	212/9376	1.54807630048821	RASGRP2/RAP1B/F2R/VEGFA/SIPA1L2/ACTG1/PDGFRA/MRAS/PDGFRB/PDGFD/RRAS/THBS1/LPAR1/PIK3R1/AKT3/MAPK14/IGF1R/CALM2/ADCY1/INSR/FGF2/GNAI2/MAGI1/CNR1/FGF7/APBB1IP/TLN2/RAP1A/MAGI3/EGFR/DOCK4/BCAR1/PRKCA/SRC/TLN1/VEGFB/ADCY3/KDR/PDGFC/ITGB3/PIK3CA/PFN2/ITGB2/AKT2/CRK/RALA/MAPK1/RAF1/CSF1/MAP2K1/KRIT1/EFNA5/MAP2K2/KRAS/VEGFC/SIPA1/EVL/PRKCI/LCP2/ADCY7/GNAO1/GNAQ/VAV1/IGF1/P2RY1/MAP2K3/RALGDS/PARD6G/ITGB1/RAC2/PIK3CD/PRKD2/ITGAM/PRKD1/PDGFA/RHOA/ADORA2B/FGF10/PLCG1/ITGAL/PLCB2/PLCE1/ENAH/ADCY9/F2RL3/RASSF5/LPAR5/EPHA2/MAGI2/LAT/ARAP3/RASGRP3/TEK/ANGPT2/MAPK12/MAPK11/SKAP1/PARD6A/FPR1/ADCY6/PIK3R2/PFN4	5.42017549400547
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	52/2914	90/9376	1.85904064668649	FOXO1/IRS2/IRS1/RHEB/PIK3R1/AKT3/IGF1R/ADCY1/INSR/PRKACB/RB1CC1/CREB3/CREB3L2/CAT/CREB3L1/SOD2/SESN3/RELA/ULK1/PRKAG1/ADCY3/PRKAG2/PIK3CA/ATG5/PRKAA1/AKT2/ATF2/ATF6B/CREB5/CREB1/CAMKK2/PRKACA/NFKB1/STK11/KRAS/SESN1/RPS6KB1/APPL1/ATG13/ADCY7/IGF1/PIK3CD/FOXO3/EHMT2/PRKAB1/ADCY9/MTOR/TSC2/KL/ADCY6/PIK3R2/PRKAA2	5.49879543796616
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	60/2914	110/9376	1.75503837274599	NBL1/FBN1/LEFTY2/DCN/ID4/EMP3/NCOR1/THBS1/INHBB/TGFBR1/FST/FMOD/CHRD/SMAD5/TGFBR2/BMPR2/HAMP/SMAD9/CDKN2B/ZFYVE16/CREBBP/ACVR1/BAMBI/SKIL/SMAD2/LTBP1/MAPK1/PPP2CA/BMP4/SMAD1/TGIF1/SKI/PPP2CB/SMAD4/BMPR1A/SMAD3/RPS6KB1/THSD4/NEO1/TGFB2/ROCK1/SMURF2/INHBA/RGMA/LEMD3/GDF7/ZFYVE9/ACVR1B/GREM1/RHOA/SP1/MYC/SIN3A/ACVR2A/HFE/BMP2/SMAD7/TGFB3/TGIF2/RGMB	5.34892063088553
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	64/2914	120/9376	1.7160375200183	MAP3K5/RAP1B/IRS1/PIK3R1/AKT3/MAPK14/MAPK7/CALM2/KIDINS220/ABL1/MAPKAPK2/RPS6KA3/NTRK1/BCL2/RAP1A/PTPN11/RELA/ARHGDIA/SHC2/JUN/PDPK1/PIK3CA/AKT2/CRK/MAPK1/RAF1/IKBKB/MAP3K3/MAPK10/NFKB1/SHC1/MAP2K1/MAPK8/IRAK1/MAP2K2/KRAS/PRDM4/IRAK3/IRAK4/FRS2/BAD/SOS2/PSEN1/RIPK2/SH2B1/MAP2K7/SH2B3/PSEN2/CAMK2D/MAP2K5/TRAF6/PIK3CD/FOXO3/NTRK2/NFKBIE/RHOA/RPS6KA2/PLCG1/MATK/PLCG2/MAPK12/MAPK11/SHC3/PIK3R2	5.30104712301964
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	56/2914	101/9376	1.78399940199923	F3/FOXO1/VEGFA/PIM1/SERPINE1/PIK3R1/AKT3/STAT1/MAPK14/VCAM1/STAT3/COL4A4/TGFBR1/PLCD3/MMP2/BCL2/TGFBR2/RELA/PRKCA/VEGFB/JUN/PLCD1/CDK4/PIK3CA/STAT5B/SMAD2/AKT2/MAPK1/MAPK10/NFKB1/MAPK8/CDKN1B/SMAD4/KRAS/SMAD3/VEGFC/JAK2/TGFB2/AGTR1/COL4A3/NOX4/COL4A6/PIK3CD/CYBB/ICAM1/PLCG1/PLCB2/STAT5A/PLCE1/AGT/PLCG2/MAPK12/TGFB3/MAPK11/PIK3R2/NFATC1	5.31944587396432
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	91/2914	187/9376	1.56576952862633	IFI16/ANTXR1/TXNIP/CTSB/PKN1/STAT1/MAPK14/IFNAR1/GABARAPL1/GABARAP/MAP1LC3A/FADD/CARD16/GBP1/TXN/ANTXR2/MYD88/BCL2/JAK1/NLRP1/CARD9/BCL2L1/GBP3/TANK/RELA/GABARAPL2/STAT2/BIRC2/RNASEL/NAMPT/SHARPIN/CASP1/JUN/GBP2/OAS1/IKBKG/XIAP/OAS2/TP53BP1/ATG5/GPSM3/MAPK1/IL18/IKBKB/ITPR2/MAPK10/NFKB1/MAPK8/GBP4/MFN1/MAP3K7/PYCARD/PKN2/NAIP/TRAF3/IRAK4/CAMP/TLR4/BIRC3/TRPM7/CARD6/RIPK2/ATG16L1/IRF7/MAVS/PANX1/TAB2/RIPK1/IRF9/MAP1LC3B/TRAF6/TRAF5/CHUK/CYBB/GBP5/TICAM1/RHOA/PLCB2/NOD1/MCU/IKBKE/P2RX7/PSTPIP1/NLRX1/TRPV2/CYBA/TAB3/MAPK12/MAPK11/TYK2/CCL5	5.2477503464837
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	116/2914	253/9376	1.47524964665605	C3/CD44/FOXO1/MYL9/ACTG1/CAPN2/UBE2D1/ROCK2/IL1R1/PIK3R1/AKT3/MAPK14/TNFRSF1A/RRAGA/CAST/MAP1LC3A/TRADD/PLCD3/CYTH2/CALCOCO2/VCL/FBXW11/MYD88/BCL2/TLN2/ILK/WIPI1/EGFR/ARHGEF2/BCL2L1/CAPNS1/BCAR1/RELA/BECN1/SRC/ARF1/TLN1/SHARPIN/CASP1/JUN/UBE2V2/WASL/PLCD1/WASF2/IKBKG/TNIP1/PIK3CA/ATG5/PFN2/FNBP1/PTK2/CTTN/MALT1/AKT2/CRK/MAPK1/IL18/IKBKB/PPID/ITPR2/MAPK10/WASF1/NFKB1/MAPK8/RRAGD/WIPI2/RRAGC/MAP3K7/RRAGB/MYL5/PYCARD/GSK3A/RPS6KB1/NAIP/TLR4/ATM/ROCK1/RIPK2/SQSTM1/U2AF1L4/CD14/ATG16L1/TAB2/CYTH4/RIPK1/ATG14/MAP1LC3B/TRAF6/PIK3C3/ITGB1/TRAF5/PIK3CD/TLR5/DOCK1/CYTH1/CHUK/FOXO3/RHOA/ELMO2/PLCG1/PIK3R4/PLCB2/NOD1/PLCE1/MYL12B/UBE2D3/MTOR/HK3/ARPC2/PLCG2/TAB3/MAPK12/MAPK11/PIK3R2/PFN4/CCL5	5.14588600105797
Organismal Systems	Immune system	hsa04611	Platelet activation	66/2914	126/9376	1.68539399287512	RASGRP2/RAP1B/F2R/ACTG1/FYN/ROCK2/PIK3R1/AKT3/MAPK14/TBXA2R/ADCY1/LYN/PRKACB/GNAI2/FERMT3/PTGIR/APBB1IP/SNAP23/MYLK/TLN2/RAP1A/STIM1/SRC/TLN1/ADCY3/GNA13/ITGB3/ARHGEF12/PIK3CA/AKT2/MAPK1/ITPR2/PRKACA/ARHGAP35/TBXAS1/PPP1R12A/SYK/PRKCI/LCP2/ADCY7/FCGR2A/ARHGEF1/ROCK1/GNAQ/ITGA2/P2RY1/PTGS1/ITGB1/BTK/PIK3CD/FCER1G/RHOA/PIK3R5/PLCB2/MYL12B/ADCY9/F2RL3/FGG/PLCG2/MAPK12/PRKG1/MAPK11/PIK3CG/ADCY6/PIK3R2/GUCY1A2	5.2011770193008
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	64/2914	122/9376	1.68790575739505	IRS2/IGFBP3/IRS1/SOCS2/PIK3R1/AKT3/STAT1/MAPK14/STAT3/ADCY1/PRKACB/GNAI2/CREB3/CREB3L2/CREB3L1/BCAR1/CREBBP/PRKCA/SHC2/ADCY3/SOCS1/PIK3CA/STAT5B/PTK2/AKT2/CRK/MAPK1/ATF2/RAF1/ATF6B/ITPR2/CREB5/MAPK10/CREB1/PRKACA/SHC1/MAP2K1/MAPK8/MAP2K2/KRAS/GNA11/JAK2/ADCY7/SOS2/GNAQ/CSH1/IGF1/MAP2K3/SOCS3/PIK3CD/MAP2K4/PLCG1/PLCB2/STAT5A/CSH2/ADCY9/MTOR/CACNA1C/PLCG2/MAPK12/MAPK11/SHC3/ADCY6/PIK3R2	5.13559830803111
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	72/2914	142/9376	1.63144412114416	SDC2/PLAT/NFE2L2/MAP3K5/VEGFA/GSTT1/ACTG1/IL1R1/PIK3R1/AKT3/MAPK14/MAPK7/VCAM1/TNFRSF1A/CALM2/ITGAV/GSTM3/MEF2A/TXN/MMP2/DUSP1/BCL2/CAV2/ARHGEF2/ASS1/MGST1/BMPR2/RELA/ACVR1/SRC/JUN/KDR/IKBKG/ITGB3/KEAP1/PIK3CA/PRKAA1/PTK2/AKT2/IKBKB/NCF2/MAPK10/BMP4/NFKB1/MAPK8/HSP90B1/BMPR1A/SUMO1/MAP3K7/IL1R2/MMP9/SQSTM1/MAP2K7/SUMO2/GSTO1/MAP2K5/RAC2/PIK3CD/MAP2K4/CHUK/PDGFA/RHOA/MEF2C/ICAM1/CAV1/ACVR2A/PIAS4/CYBA/MAPK12/MAPK11/PIK3R2/PRKAA2	5.09132823208067
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	101/2914	216/9376	1.5045120618216	NFE2L2/MAP3K5/RAP1B/APOA1/ROCK2/PIK3R1/AKT3/MAPK14/VCAM1/TNFRSF1A/CALM2/STAT3/LYN/ERN1/ABCA1/FAS/MYD88/BCL2/RAP1A/BCL2L1/SOD2/TANK/RELA/PRKCA/PPP3CC/PPP3CB/SRC/CASP1/JUN/IKBKG/PDPK1/PIK3CA/LY96/PTK2/AKT2/MAPK1/IL18/IKBKB/NCF2/MAPK10/NFKB1/MAPK8/IRAK1/HSP90B1/KRAS/BID/MAP3K7/RXRB/PYCARD/ATF6/TRAF3/JAK2/IRAK4/BAD/TLR4/MIB1/ARHGEF1/MMP1/CD36/MMP9/CD40/MAP2K7/CD14/IRF7/CYP2A6/TAB2/MIB2/CAMK2D/VAV1/MAP2K3/TRAF6/PIK3CD/EIF2AK3/ABCG1/MAP2K4/TLR2/CYP2A7/CHUK/CYBB/POU2F2/TICAM1/RHOA/ICAM1/PLCG1/PLCB2/NFATC3/MMP3/XBP1/HSPA1A/IKBKE/CYBA/HSPA6/MAPK12/MAPK11/TLR6/NFATC2/PIK3R2/HSPA5/CCL5/NFATC1/OLR1	5.03729781055809
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	38/2914	62/9376	1.97205924679523	TLE2/LFNG/NCOR2/RFNG/PSENEN/APH1A/ATXN1/CREBBP/CTBP2/RBPJ/NUMBL/APH1B/DTX3L/DLL1/MAML2/SNW1/TLE6/NOTCH1/DVL2/DTX3/NOTCH2/TLE4/PSEN1/DTX1/MAML1/PSEN2/NUMB/ATXN1L/MAML3/NOTCH3/MFNG/HES1/KAT2B/NOTCH4/HEYL/PTCRA/JAG1/NRARP	5.15664695561891
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	100/2914	214/9376	1.50353754674501	GNG4/CFL2/HLA-B/HLA-E/HLA-A/B2M/HLA-C/TNFRSF1B/PIK3R1/AKT3/MAPK14/TNFRSF1A/AP1S2/CALM2/HLA-F/GNAI2/FADD/TRADD/GNG11/SAMHD1/FAS/FBXW11/TAP1/MYD88/BCL2/GNB5/BCL2L1/TAPBPL/TAPBP/PAK3/RELA/PRKCA/PPP3CC/PPP3CB/AP1M1/JUN/IKBKG/LIMK1/CUL5/GNB2/PIK3CA/NFATC4/PTK2/AKT2/CRK/MAPK1/RAF1/IKBKB/ITPR2/MAPK10/NFKB1/MAP2K1/MAPK8/IRAK1/GNB1/GNG2/MAP2K2/KRAS/BID/MAP3K7/CXCR4/GNA11/RPS6KB1/IRAK4/BAD/TLR4/ATM/GNAO1/GNB4/MAP2K7/CFL1/GNAQ/RNF7/CD4/TAB2/RIPK1/PAK2/MAP2K3/TRAF6/RAC2/TRAF5/PIK3CD/APOBEC3G/TLR2/ATR/CHUK/PLCG1/NFATC3/BST2/MTOR/PLCG2/GNGT2/MAPK12/MAPK11/CD247/NFATC2/GNB3/CD3E/PIK3R2/NFATC1	5.00369163886879
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	78/2914	158/9376	1.58842080571314	CAB39L/WNT4/MAPKAP1/DEPTOR/IRS1/RHEB/WNT5A/PIK3R1/AKT3/IGF1R/TNFRSF1A/RRAGA/ATP6V1D/INSR/WNT5B/RPS6KA3/RNF152/CAB39/WNT9A/PRKCA/ULK1/ULK2/LAMTOR1/WNT2/PDPK1/SLC3A2/PIK3CA/ATP6V1H/PRKAA1/AKT2/MAPK1/LPIN1/RAF1/IKBKB/SEC13/WNT6/LPIN2/FZD2/ATP6V1C1/MAP2K1/ATP6V1G1/RRAGD/STK11/SGK1/MAP2K2/RRAGC/KRAS/RRAGB/RPS6KB1/DVL2/SOS2/DDIT4/IGF1/ATP6V1B2/LPIN3/PIK3CD/CHUK/RHOA/LAMTOR2/FZD3/WNT3/LRP6/RPS6KA2/FNIP2/WDR59/WDR24/FZD10/MTOR/TSC2/PRR5L/FZD4/FZD1/LAMTOR4/ATP6V1E2/ATP6V1G2/FZD8/PIK3R2/PRKAA2	5.00893212868031
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	58/2914	109/9376	1.7121016541467	CTSK/PIK3R1/AKT3/STAT1/MAPK14/IFNAR1/SPP1/FADD/MYD88/JAK1/RELA/STAT2/TOLLIP/JUN/IKBKG/PIK3CA/LY96/CD86/AKT2/MAPK1/IKBKB/MAPK10/NFKB1/MAP2K1/MAPK8/IRAK1/MAP2K2/MAP3K7/TRAF3/IRAK4/TLR4/CD40/CXCL10/MAP2K7/CD14/IRF7/TLR1/TAB2/CXCL9/RIPK1/IRF9/MAP2K3/TRAF6/TLR7/PIK3CD/TLR5/MAP2K4/TLR2/CHUK/TICAM1/IRF5/IKBKE/MAPK12/MAPK11/TYK2/TLR6/PIK3R2/CCL5	5.02148994190223
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	58/2914	109/9376	1.7121016541467	FOXO1/IRS2/IRS1/PIK3R1/AKT3/TNFRSF1A/GFPT2/STAT3/INSR/RPS6KA3/CREB3/CREB3L2/NR1H2/ACACB/CREB3L1/PTPN11/RELA/PRKAG1/PRKAG2/PDPK1/PIK3CA/PRKAA1/PTPN1/AKT2/IKBKB/MLX/CREB5/MAPK10/CREB1/NFKB1/MAPK8/TBC1D4/G6PC3/SLC27A3/NR1H3/RPS6KB1/MLXIP/SLC27A4/PPARA/CD36/SLC27A1/PPP1R3C/PPP1R3D/SOCS3/PIK3CD/PYGB/PRKAB1/OGT/RPS6KA2/CRTC2/AGT/CPT1A/MTOR/TRIB3/PPP1R3E/PIK3R2/PYGM/PRKAA2	5.02148994190223
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	35/2914	56/9376	2.01098146877145	GAS1/PRKACB/SPOP/FBXW11/SCUBE2/BCL2/GPR161/CSNK1E/CSNK1D/CSNK1G3/BOC/CUL3/PRKACA/CSNK1G2/KIF3A/IQCE/CCND2/CSNK1A1/SMURF2/MEGF8/CSNK1G1/EVC/GLI2/DISP1/ARRB2/EFCAB7/SPOPL/PTCH1/EVC2/SMO/SUFU/ARRB1/MGRN1/KIF7/CDON	5.09537541712499
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	94/2914	200/9376	1.51225806451613	TUBA1A/F2R/ACTG1/FYN/ROCK2/LPAR1/IL1R1/MAPK14/TNFRSF1A/TJP1/ABL1/FADD/TRADD/CYTH2/FAS/MYD88/NCK1/ARHGEF2/MYO5A/TUBA3E/PAK3/MYO6/PTPN11/RELA/MYO1E/SRC/ARF1/CASP1/JUN/WASL/GNA13/WASF2/IKBKG/ABCF2/ARHGEF12/MYO1C/CTTN/ABI1/MYO10/MAPK1/IL18/IKBKB/BRK1/MAPK10/TUBB2A/MYH11/WASF1/NFKB1/MAPK8/IRAK1/NCKAP1L/WIPF1/MAP3K7/CLDN10/PYCARD/SEC24D/NAIP/IRAK4/FCGR2A/TLR4/ARHGEF1/MYH9/WIPF3/ROCK1/NCK2/BAIAP2/TAB2/CYTH4/CLDN23/RIPK1/PAK2/TRAF6/ITGB1/TLR5/TMED10/MYO1F/CYTH1/CHUK/ARHGEF11/RHOA/WASF3/SEC24B/LPAR5/PTPN6/TUBB2B/TUBA3D/ARPC2/TAB3/CLDN12/MAPK12/MAPK11/TUBA4A/MYO1D/CLDN15	4.91726976571312
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	63/2914	122/9376	1.66153222993575	FOXO1/WNT4/ACTG1/NCOR1/ESR1/RHEB/PIK3R1/AKT3/STAT1/ITGAV/PRKACB/PLCD3/CREBBP/ATP2A2/PRKCA/SRC/THRA/PLCD1/DIO3/ITGB3/PDPK1/PIK3CA/HIF1A/MED13L/MED27/AKT2/MAPK1/RAF1/BMP4/PRKACA/MAP2K1/TBC1D4/MAP2K2/KRAS/RXRB/HDAC3/NOTCH1/BAD/MED13/NCOA1/NOTCH2/RCAN2/PFKM/MED17/MED1/PIK3CD/PLN/ATP1B3/MYC/PLCG1/NOTCH3/SIN3A/PLCB2/MED14/PLCE1/KAT2B/MTOR/NOTCH4/TSC2/PLCG2/PFKFB2/SLC16A10/PIK3R2	4.93870528665319
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	56/2914	105/9376	1.7160375200183	GADD45G/IL1R1/CFLAR/VCAM1/TNFRSF1A/PLAU/CXCL12/LYN/TRADD/RELB/MYD88/BCL2/BCL2L1/RELA/BIRC2/TNFSF13B/CYLD/LTBR/IKBKG/XIAP/UBE2I/LY96/CSNK2A1/MALT1/IKBKB/NFKB2/NFKB1/IRAK1/TRIM25/MAP3K7/SYK/TRAF3/IRAK4/TLR4/ATM/CD40/BIRC3/CD14/TAB2/RIPK1/TRAF6/BTK/TRAF5/CHUK/TICAM1/ICAM1/PLCG1/TNFSF14/GADD45A/PIAS4/LAT/PLCG2/TAB3/GADD45B/TRAF1/ZAP70	4.95466246680716
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	56/2914	105/9376	1.7160375200183	MRAS/BNIP3L/RRAS/GABARAPL1/GABARAP/MAP1LC3A/OPTN/CALCOCO2/CCZ1/MITF/AMFR/PINK1/BCL2L1/RELA/NBR1/GABARAPL2/BECN1/SRC/ULK1/RRAS2/JUN/TFE3/RAB7A/RAB5C/RAB5A/HIF1A/CSNK2A1/TBC1D15/MUL1/MAPK10/USP8/MAPK8/FUNDC1/FKBP8/MFN1/KRAS/TAX1BP1/MON1B/RHOT1/TBC1D17/RAB5B/SQSTM1/CITED2/SMURF2/ARIH1/MAP1LC3B/EIF2AK3/MON1A/FOXO3/SP1/TOMM40L/NLRX1/AMBRA1/FIS1/MTX3/USP30	4.95466246680716
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	44/2914	78/9376	1.81503968463474	PIP5K1C/ITPK1/PLCD3/PI4K2A/MINPP1/CDIPT/PLCD1/MTMR6/INPP1/ITPKC/PIK3CA/SACM1L/PIP4K2A/PPIP5K2/IP6K3/INPP4B/INPP5K/IP6K2/MTMR3/PIP4K2B/FIG4/ALDH6A1/MTMR14/IP6K1/PIK3C3/MTMR2/PIK3CD/OCRL/PI4KB/INPP4A/PLCG1/INPPL1/ITPKB/PLCB2/PLCE1/PIKFYVE/SYNJ2/PIP5K1B/INPP5D/MTM1/PLCG2/INPP5E/ITPKA/PIK3CG	4.85375913300459
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	73/2914	149/9376	1.57639352719802	SPHK1/F2R/PDGFRA/MRAS/PDGFRB/FYN/PDGFD/PIP5K1C/RRAS/RHEB/LPAR1/PIK3R1/AKT3/ADCY1/INSR/PLD1/CYTH2/EGFR/PTPN11/PRKCA/ARF1/RRAS2/SHC2/ADCY3/GNA13/PDGFC/AGPAT1/AGPAT3/PIK3CA/AKT2/DGKH/RALA/MAPK1/RAF1/SHC1/AGPAT2/MAP2K1/MAP2K2/KRAS/DGKE/LPAR6/SYK/GAB2/ADCY7/SOS2/AGTR1/DNM1/AGPAT4/CYTH4/RALGDS/PIK3CD/CYTH1/SPHK2/PDGFA/FCER1G/RHOA/AVPR1A/DGKA/PIK3R5/PLCG1/PLCB2/ADCY9/AGT/MTOR/LPAR5/TSC2/PIP5K1B/PLCG2/PIK3CG/DGKD/SHC3/ADCY6/PIK3R2	4.76243327646337
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	76/2914	157/9376	1.55754997836056	ZFP36L2/FOXO1/HLA-B/HLA-E/HLA-A/IGFBP3/CHEK2/GADD45G/MRAS/CAPN2/HLA-C/RRAS/SERPINE1/RHEB/NBN/PIK3R1/AKT3/MAPK14/CALM2/HLA-F/MAPKAPK2/TGFBR1/FBXW11/RAD50/TGFBR2/ETS1/CDKN2B/RELA/PPP3CC/PPP3CB/RB1/RRAS2/HIPK3/CDK4/HIPK2/PIK3CA/SMAD2/NFATC4/TRAF3IP2/RBL2/AKT2/MAPK1/RAF1/PPID/ITPR2/NFKB1/MAP2K1/HUS1/MAP2K2/KRAS/SMAD3/TGFB2/CCND2/ATM/TRPM7/SQSTM1/MAP2K3/PIK3CD/LIN52/ATR/FOXO3/CDKN1A/MYC/NFATC3/MCU/MTOR/RASSF5/TSC2/GADD45A/GADD45B/MAPK12/TGFB3/MAPK11/NFATC2/PIK3R2/NFATC1	4.73084432355665
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	68/2914	137/9376	1.59704221753528	CTSK/MAP3K5/TUBA1A/CTSB/CTSS/CTSC/ACTG1/GADD45G/PTPN13/DAXX/CAPN2/CTSD/PIK3R1/CFLAR/AKT3/TNFRSF1A/PARP4/SPTAN1/CTSH/CTSO/FADD/TRADD/ERN1/FAS/NTRK1/BCL2/TUBA3E/BCL2L1/RELA/BIRC2/JUN/IKBKG/XIAP/PDPK1/HTRA2/PIK3CA/AKT2/MAPK1/RAF1/IKBKB/ITPR2/MAPK10/CTSF/CTSZ/NFKB1/MAP2K1/MAPK8/PARP3/MAP2K2/KRAS/BID/BAD/ATM/BIRC3/BCL2L11/RIPK1/PIK3CD/EIF2AK3/CHUK/LMNA/CASP10/GADD45A/TUBA3D/GADD45B/TUBA4A/TRAF1/PIK3R2/CTSW	4.72715428197475
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	55/2914	105/9376	1.68539399287512	MRAS/RRAS/PIK3R1/AKT3/STAT1/MAPK14/CALM2/MAPKAPK2/RELB/LSP1/CARD9/PLK3/PTPN11/RELA/PPP3CC/STAT2/PPP3CB/SRC/RRAS2/CYLD/CASP1/JUN/IKBKG/ARHGEF12/PIK3CA/NFATC4/MALT1/AKT2/MAPK1/RAF1/IKBKB/ITPR2/MAPK10/NFKB2/NFKB1/MAPK8/KRAS/BCL3/PYCARD/CLEC4M/SYK/IRF9/PIK3CD/CHUK/FCER1G/RHOA/IL10/NFATC3/IKBKE/PLCG2/MAPK12/MAPK11/NFATC2/PIK3R2/NFATC1	4.74262283265079
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	59/2914	115/9376	1.65075348393065	AKAP13/ADCY1/PLD1/PRKACB/GNAI2/MEF2A/MAFB/CREB3/CREB3L2/BCL2/MMP14/EGFR/CREB3L1/PDE4B/WNK1/PRKCA/ADCY3/GNA13/MMP17/OXSR1/MAPK1/ATF2/RAF1/ATF6B/ITPR2/CREB5/CREB1/PTHLH/PRKACA/MEF2D/MAP2K1/STK39/SGK1/ARAF/RXRB/GNA11/WNK3/JUND/ADCY7/ARHGEF1/VDR/GNAQ/PDE4A/ARRB2/ARHGEF11/CDKN1A/RHOA/MEF2C/SP1/LRP6/RUNX2/PLCB2/WNK2/HBEGF/ARRB1/ADCY9/NR4A2/KL/ADCY6	4.71501865120896
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	40/2914	70/9376	1.83861162859104	IRS2/IRS1/TNFRSF1B/AKT3/TNFRSF1A/STAT3/TRADD/ACACB/PTPN11/RELA/ACSL3/PRKAG1/PRKAG2/IKBKG/PRKAA1/AKT2/IKBKB/ACSL1/MAPK10/CAMKK2/NFKB1/MAPK8/STK11/G6PC3/CPT1C/RXRB/APPL1/JAK2/PPARA/CD36/SOCS3/CHUK/NFKBIE/LEPR/PRKAB1/CPT1A/POMC/MTOR/ACSL5/PRKAA2	4.72906530366383
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	82/2914	174/9376	1.51632625691272	NFE2L2/MAP3K5/CAPN2/UBE2D1/BAG2/DNAJC3/SEC62/UBXN6/ERN1/SAR1B/SEC63/MBTPS1/BCL2/SEC31A/DERL1/AMFR/SEC23A/DNAJB12/DNAJC1/SEL1L/DNAJC10/UBXN2A/DERL2/BCAP29/ERLEC1/UGGT2/OS9/RNF5/MAN1A1/STUB1/EDEM3/HSPBP1/SEC61A1/SEC61B/TRAM1/UBQLN1/ATF6B/SSR1/HERPUD1/HYOU1/SEC13/UBE2G2/MAPK10/RPN1/MAPK8/UBE2J1/HSP90B1/SIL1/DNAJB2/SSR2/PLAA/MAN1C1/SEC24D/FBXO6/ATF6/ATXN3/UBE2G1/BAG1/UBXN1/UBQLN2/RAD23B/DAD1/SYVN1/MAP2K7/DNAJC5/TXNDC5/CRYAB/EIF2AK3/UBQLN4/RNF185/SEC24B/UBXN4/UBE2D3/XBP1/HSPA1A/SEC61A2/PPP1R15A/HSPA6/OSTC/SEC61G/YOD1/HSPA5	4.61641300359923
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	104/2914	232/9376	1.44235912242918	CFL2/ITGB5/GSN/RGCC/F2R/MYL9/ACTG1/TMSB4X/PDGFRA/MRAS/ITGB8/PDGFRB/PDGFD/PIP5K1C/RRAS/ROCK2/MSN/LPAR1/PIK3R1/AKT3/ITGAV/CXCL12/FGF2/BDKRB2/VCL/FGF7/MYLK/EGFR/ITGAE/PAK3/BCAR1/SRC/ABI2/RRAS2/WASL/GNA13/WASF2/PDGFC/LIMK1/ITGB3/BDKRB1/ARHGEF12/SSH1/PIK3CA/APC/PFN2/ITGB2/PTK2/AKT2/CRK/MAPK1/RAF1/BRK1/MYH11/WASF1/ITGA3/MAP2K1/NCKAP1L/ARAF/MAP2K2/PIP4K2A/ARHGAP35/KRAS/MYL5/CXCR4/ITGA1/DIAPH2/PPP1R12A/PIP4K2B/SOS2/ARHGEF1/MYH9/ROCK1/CFL1/BAIAP2/ITGA2/PPP1R12B/ARHGEF7/VAV1/PAK2/ITGB1/RAC2/PIK3CD/ARHGEF6/ITGAM/ITGAX/DOCK1/PDGFA/RHOA/FGF10/ITGA4/ITGAL/MYL12B/ENAH/PIKFYVE/IQGAP2/LPAR5/PIP5K1B/ARPC2/FGD1/ITGAD/C5/PIK3R2/PFN4	4.58139572927888
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	44/2914	80/9376	1.76966369251887	AXL/VEGFA/PDGFRA/PDGFRB/PDGFD/PIK3R1/AKT3/IGF1R/STAT3/FGF2/BCL2/JAK1/EGFR/BCL2L1/PRKCA/SRC/GAS6/SHC2/KDR/PDGFC/PIK3CA/IL6R/AKT2/MAPK1/RAF1/SHC1/MAP2K1/ARAF/MAP2K2/KRAS/RPS6KB1/JAK2/BAD/SOS2/BCL2L11/IGF1/PIK3CD/FOXO3/PDGFA/PLCG1/MTOR/PLCG2/SHC3/PIK3R2	4.64242473011145
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	151/2914	362/9376	1.34213569849498	PRLR/GNG4/ITGB5/F2R/VEGFA/PDGFRA/IRS1/ITGB8/PDGFRB/PDGFD/TNXB/PKN1/THBS1/RHEB/PRL/LAMA4/LPAR1/PIK3R1/AKT3/IFNAR1/IGF1R/ITGAV/COL4A4/OSMR/INSR/LAMB2/FGF2/SPP1/VTN/MAGI1/GNG11/CREB3/FGF7/IL4R/NTRK1/CREB3L2/BCL2/JAK1/EGFR/PPP2R3C/THBS3/GNB5/CREB3L1/BCL2L1/LAMC1/RELA/PRKCA/VEGFB/PPP2R5E/KDR/COL6A3/PDGFC/TNC/CDK4/IKBKG/ITGB3/GNB2/PDPK1/PIK3CA/IL6R/PRKAA1/RBL2/PPP2R5B/PTK2/AKT2/MAPK1/ATF2/RAF1/PPP2CA/ATF6B/IKBKB/CSF1/YWHAQ/CREB5/CREB1/NFKB1/ITGA3/MAP2K1/CDKN1B/STK11/PPP2CB/EFNA5/GNB1/SGK1/HSP90B1/GNG2/MAP2K2/KRAS/G6PC3/LPAR6/PPP2R2D/PKN2/ITGA1/RPS6KB1/VEGFC/SYK/JAK2/LAMA3/BAD/SOS2/TLR4/CCND2/GNB4/PIK3AP1/DDIT4/PHLPP2/CSH1/SGK3/ITGA2/COL4A3/BCL2L11/IGF1/PPP2R3A/EPOR/ITGB1/COL4A6/PIK3CD/IL2RA/THBS2/FLT3LG/TLR2/CHUK/FOXO3/LAMB1/NTRK2/IL2RG/PDGFA/CDKN1A/PIK3R5/FGF10/MYC/ITGA4/CSH2/CRTC2/LAMC3/LAMB3/MTOR/LPAR5/TSC2/EPHA2/MAGI2/OSM/JAK3/TEK/GNGT2/ANGPT2/PIK3CG/GNB3/COMP/PIK3R2/PRKAA2	4.45800790643968
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	40/2914	71/9376	1.81271569016018	PRLR/SOCS2/ESR1/PRL/PIK3R1/AKT3/STAT1/MAPK14/STAT3/SOCS5/CISH/RELA/SRC/SHC2/SOCS1/PIK3CA/STAT5B/AKT2/MAPK1/RAF1/SOCS4/MAPK10/NFKB1/SHC1/MAP2K1/MAPK8/MAP2K2/KRAS/JAK2/SOCS6/SOS2/CCND2/SOCS3/PIK3CD/FOXO3/STAT5A/MAPK12/MAPK11/SHC3/PIK3R2	4.61590184266259
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	81/2914	173/9376	1.50649247602763	ACTG1/IFNGR2/HLA-DPB1/HLA-DQA2/HLA-DRA/PIK3R1/AKT3/STAT1/IFNAR1/TNFRSF1A/HLA-DPA1/DNAJC3/FADD/MX2/IFNGR1/HLA-DMB/TRADD/CALCOCO2/FAS/MYD88/HLA-DMA/JAK1/MX1/HLA-DQA1/CREBBP/RELA/PRKCA/STAT2/RAB11B/RNASEL/CASP1/OAS1/CDK4/IKBKG/EIF2AK2/OAS2/PML/PIK3CA/HLA-DRB1/HNRNPUL1/AKT2/MAPK1/RAF1/IL18/IKBKB/ADAR/NFKB1/HLA-DQB1/MAP2K1/TRIM25/MAP2K2/NXT1/BID/PYCARD/KPNA6/KPNA1/TRAF3/JAK2/IRAK4/TLR4/CXCL10/IRF7/KPNA5/MAVS/HLA-DOA/IRF9/TLR7/SOCS3/PIK3CD/CIITA/CHUK/RSAD2/IFIH1/TICAM1/ICAM1/IKBKE/NLRX1/TYK2/PIK3R2/HLA-DRB5/CCL5	4.51521332673226
NA	NA	hsa04517	IgSF CAM signaling	128/2914	299/9376	1.37742142075048	FOXO1/CLMP/RAP1B/TUBA1A/MYL9/ACTG1/MYL6/FYN/PMP22/MSN/PPFIA1/JAM2/PIK3R1/AKT3/MAPK14/LRFN4/TJP1/SPTAN1/UNC5B/PLXNA4/LYN/MBP/ABL1/DOK1/TRPC6/MAGI1/VCL/SPTBN1/NLGN4X/MYLK/NCK1/RAP1A/CADM4/TUBA3E/PAK3/EPB41L2/CD84/BCAR1/PTPN11/SORBS1/PRKCA/SRC/CDH2/WASL/KDR/ITGB3/CXADR/PDPK1/ICAM2/PIK3CA/CD86/ITGB2/PTK2/AKT2/MAPK1/SRGAP1/CASK/CSK/NLGN2/MAPK10/TUBB2A/MYH11/MYL6B/MAP2K1/MAPK8/MAP2K2/CD48/CLEC4M/PRKCI/LCP2/NRP1/PTPRD/MYH9/DOK2/NCK2/CNTN1/BAIAP2/SLITRK4/CD226/VAV1/PAK2/TRAF6/PARD6G/ITGB1/NLGN1/APP/PIK3CD/ITGAM/ITGAX/CADM1/RHOA/NCAM2/SLIT3/ICAM1/NCAM1/ITGA4/PLCG1/ITGAL/MYL12B/PLXNA1/FGG/CD2/CRTAM/EPB41L1/PTPN6/SLAMF7/MAGI2/TUBB2B/TUBA3D/ARPC2/CASKIN2/ROBO2/INPP5D/PLCG2/NFASC/MAPK12/SRGAP3/LRFN5/MAPK11/TUBA4A/PARD6A/ANK2/NRP2/CD96/CABLES2/PIK3R2/CNTNAP1/CABLES1	4.45387379452865
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	68/2914	140/9376	1.56281988430238	SPHK1/GNG4/PLAT/MRAS/RRAS/SERPINE1/AKT3/CALM2/ADCY1/MAP1LC3A/PRKACB/GNAI2/SPP1/TGFBR1/MEF2A/GNG11/MYLK/GNB5/BECN1/RRAS2/PRKAG1/ADCY3/GNA13/PRKAG2/GNB2/SMAD2/PRKAA1/AKT2/MAPK1/RAF1/ITPR2/PRKACA/MEF2D/MAP2K1/GNB1/SMAD4/GNG2/MAP2K2/KRAS/SMAD3/RPS6KB1/ADCY7/SLC8A1/GNB4/AGTR1/GNAQ/MAP1LC3B/PIK3C3/SPHK2/ACTA2/MEF2C/PRKAB1/PIK3R5/NOTCH3/PIK3R4/PLCB2/HDAC4/ADCY9/MTOR/LIPE/GNGT2/PIK3CG/PDE3B/ADCY6/GNB3/NRF1/JAG1/PRKAA2	4.50545258274924
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	49/2914	93/9376	1.69527900163098	GADD45G/LAMA4/PIK3R1/AKT3/ITGAV/COL4A4/LAMB2/BCL2/POLK/BCL2L1/LAMC1/CDKN2B/RELA/RB1/BIRC2/MAX/CDK4/IKBKG/XIAP/PIK3CA/PTK2/AKT2/IKBKB/NFKB1/ITGA3/CDKN1B/RXRB/TRAF3/LAMA3/BIRC3/ITGA2/COL4A3/TRAF6/DDB2/ITGB1/COL4A6/TRAF5/PIK3CD/CHUK/LAMB1/ZBTB17/CDKN1A/MYC/LAMC3/LAMB3/GADD45A/GADD45B/TRAF1/PIK3R2	4.52484125470645
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	67/2914	138/9376	1.56215372066883	FOXO1/IRS2/IRS1/SOCS2/RHEB/PIK3R1/AKT3/CALM2/INSR/PRKACB/TRIP10/RHOQ/ACACB/EXOC7/SORBS1/FLOT1/PRKAG1/SHC2/PRKAR1A/FBP1/SOCS1/PRKAG2/PDPK1/PIK3CA/PRKAA1/PTPN1/AKT2/CRK/MAPK1/RAF1/IKBKB/SOCS4/MAPK10/PRKAR2A/PRKACA/SHC1/MAP2K1/MAPK8/PRKAR2B/ARAF/MAP2K2/KRAS/G6PC3/RPS6KB1/PRKCI/BAD/SOS2/PPP1R3C/PPP1R3D/SOCS3/PIK3CD/ELK1/PYGB/PRKAB1/INPPL1/MTOR/TSC2/HK3/LIPE/PRKAR1B/PPP1R3F/PDE3B/PPP1R3E/SHC3/PIK3R2/PYGM/PRKAA2	4.46737684375241
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	88/2914	193/9376	1.46707870882394	GNG4/RASGRP2/RAP1B/ROCK2/GRK5/PIK3R1/AKT3/STAT1/STAT3/ADCY1/CXCL12/LYN/PRKACB/GNAI2/GNG11/RAP1A/GNB5/BCAR1/RELA/STAT2/SRC/SHC2/ADCY3/IKBKG/GNB2/PIK3CA/STAT5B/PTK2/AKT2/CRK/MAPK1/RAF1/IKBKB/PRKACA/NFKB1/SHC1/MAP2K1/CCL8/CXCL16/GNB1/GNG2/GRK4/KRAS/CXCR4/GSK3A/JAK2/BAD/ADCY7/SOS2/CXCL10/GNB4/ROCK1/DOCK2/GNAQ/FGR/CCL18/GRK6/CCL26/CXCL9/VAV1/ARRB2/RAC2/PIK3CD/CHUK/FOXO3/WAS/HCK/RHOA/PIK3R5/PPBP/PLCG1/PLCB2/ARRB1/ADCY9/JAK3/PLCG2/GNGT2/PF4/XCL2/PIK3CG/SHC3/ADCY6/GNB3/CX3CR1/CCL7/XCL1/PIK3R2/CCL5	4.40274333609696
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	91/2914	201/9376	1.45671095449315	PLAT/FOXO1/WT1/IGFBP3/GADD45G/PBX3/NCOR1/MEIS1/ZEB1/KLF3/IGF1R/PLAU/CDK14/MAF/NUPR1/CDK9/HOXA9/HOXA10/JMJD1C/KMT2A/NTRK1/HOXA11/MITF/TGFBR2/POLK/BCL2L1/RELA/BIRC2/MAX/TFE3/TSPAN7/PML/RARA/CD86/PTK2/LYL1/BMI1/ELK4/PRCC/SPI1/NFKB1/SMAD1/CDKN1B/FUT8/RXRB/SS18/RUNX1T1/ZBTB16/EWSR1/FCGR1A/IL1R2/CCNT2/SLC45A3/BMP2K/CCND2/ETV6/ATM/MMP9/CD40/LDB1/SUPT3H/GRIA3/BIRC3/PBX1/CD14/RUNX1/AFF1/IGF1/DDX5/DDB2/PER2/CDKN2C/MLLT3/ITGAM/ZBTB17/PDGFA/CDKN1A/MEF2C/SP1/MYC/SIN3A/RUNX2/CEBPB/MMP3/PAX8/GADD45A/HHEX/ARNT2/GADD45B/TRAF1/PTCRA	4.39524770543215
Human Diseases	Infectious disease: viral	hsa05162	Measles	66/2914	136/9376	1.56146796398724	MSN/PIK3R1/AKT3/STAT1/IFNAR1/STAT3/FADD/MX2/TRADD/FAS/MYD88/BCL2/RAB9A/JAK1/MX1/BCL2L1/RELA/STAT2/JUN/OAS1/CDK4/IKBKG/EIF2AK2/OAS2/PIK3CA/STAT5B/CSNK2A1/CD46/AKT2/IKBKB/ADAR/MAPK10/NFKB1/MAPK8/CDKN1B/IRAK1/BID/MAP3K7/RCHY1/CLEC4M/TRAF3/IRAK4/BAD/TLR4/CCND2/IRF7/MAVS/TAB2/IRF9/TRAF6/TLR7/PIK3CD/IL2RA/TLR2/CHUK/IL2RG/IFIH1/STAT5A/HSPA1A/IKBKE/JAK3/HSPA6/TYK2/CD3E/PIK3R2/RAB9B	4.42899699023399
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	68/2914	142/9376	1.54080833663615	UBE2D1/KLHL13/UBE2R2/UBE2L6/UBE2E3/FBXW11/KLHL9/ANAPC13/BIRC2/CDC27/SOCS1/STUB1/UBE2H/XIAP/UBE2I/CUL5/PML/KEAP1/ANAPC7/UBA2/UBE2W/UBE3A/CUL2/UBE2E2/TRIP12/HERC1/UBE2G2/CUL3/UBE2J1/UBE2B/UBE2E1/PIAS1/CDC34/CDC26/UBE3B/RCHY1/BIRC6/TRIM32/UBE2G1/HERC2/UBE2Z/UBE2M/UBA3/BIRC3/SYVN1/SMURF2/FZR1/WWP2/RNF7/WWP1/CUL7/UBR5/TRAF6/DDB2/SOCS3/UBE2QL1/DET1/UBE2D3/PIAS3/PPIL2/MGRN1/PIAS4/PIAS2/FBXW8/NHLRC1/ANAPC2/UBA7/UBOX5	4.36053272215295
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	78/2914	168/9376	1.49387194823022	PRLR/FHL1/IFNGR2/PDGFRA/IL13RA1/PDGFRB/SOCS2/IL15/PIM1/PRL/IL15RA/CLCF1/PIK3R1/AKT3/STAT1/IFNAR1/STAT3/SOCS5/OSMR/IFNGR1/IL6ST/IL4R/CISH/BCL2/JAK1/EGFR/AOX1/BCL2L1/STAM/PTPN11/CREBBP/STAT2/STAM2/SOCS1/CTF1/PIK3CA/STAT5B/IL6R/AKT2/RAF1/SOCS4/IL13RA2/PIAS1/IL11/STAT6/JAK2/SOCS6/SOS2/CCND2/IL19/CSH1/IRF9/SOCS3/EPOR/PIK3CD/IL2RA/IL2RG/PDGFA/CDKN1A/LEPR/MYC/IL10/IL27RA/IL12RB1/STAT5A/CSH2/THPO/PIAS3/MTOR/PTPN6/PIAS4/OSM/PIAS2/JAK3/TYK2/STAT4/PIK3R2/LIF	4.33743799730155
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	104/2914	238/9376	1.40599712774609	GNG4/RASGRP2/RAP1B/VEGFA/PDGFRA/MRAS/PDGFRB/PDGFD/RRAS/PIK3R1/AKT3/IGF1R/CALM2/INSR/PLD1/PRKACB/ABL1/FGF2/RASA3/GNG11/FGF7/NTRK1/RAP1A/RIN1/EGFR/SHOC2/GNB5/ETS2/BCL2L1/PAK3/ETS1/PTPN11/RELA/PRKCA/RRAS2/VEGFB/SHC2/KDR/PDGFC/IKBKG/GNB2/RAB5C/RAB5A/PIK3CA/RALGAPA1/AKT2/RALA/MAPK1/RAF1/IKBKB/CSF1/MAPK10/PRKACA/NFKB1/SHC1/MAP2K1/MAPK8/EFNA5/GNB1/GNG2/RASAL2/MAP2K2/RASSF1/KRAS/STK4/SYNGAP1/RASA2/VEGFC/GAB2/BAD/SOS2/RAB5B/GNB4/ABL2/RALGAPB/IGF1/PAK2/RALGDS/RAC2/PIK3CD/FLT3LG/ELK1/CHUK/NTRK2/PDGFA/RHOA/FGF10/PLCG1/PLCE1/EXOC2/RASA4/RASSF5/EPHA2/RASAL3/LAT/PLCG2/RASGRP3/TEK/GNGT2/ANGPT2/SHC3/GNB3/PIK3R2/ZAP70	4.26022756324358
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	45/2914	86/9376	1.68361239245982	PIK3R1/AKT3/ABL1/NCK1/EGFR/PAK3/PRKCA/SRC/SHC2/JUN/PIK3CA/STAT5B/PTK2/AKT2/CRK/MAPK1/RAF1/MAPK10/SHC1/MAP2K1/MAPK8/CDKN1B/ARAF/MAP2K2/KRAS/RPS6KB1/BAD/SOS2/MAP2K7/ABL2/NCK2/CAMK2D/PAK2/PIK3CD/MAP2K4/ELK1/CDKN1A/MYC/PLCG1/STAT5A/HBEGF/MTOR/PLCG2/SHC3/PIK3R2	4.27659605176633
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	27/2914	44/9376	1.97441816933924	PRKACB/STX4/DCTN2/CREB3/DYNC2LI1/CREB3L2/DYNC1LI1/DYNC1H1/CREB3L1/DCTN6/VAMP2/RAB11B/ARHGDIA/DYNC2H1/ADCY3/RAB5C/RAB5A/DYNC1LI2/CREB5/CREB1/PRKACA/DYNC1I2/DCTN1/RAB5B/ADCY9/AQP3/ADCY6	4.35042094979897
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	47/2914	91/9376	1.66182204891882	CD81/PIK3R1/AKT3/LYN/RELA/PPP3CC/PPP3CB/JUN/IKBKG/LILRB4/PIK3CA/MALT1/AKT2/MAPK1/RAF1/IKBKB/NFKB1/MAP2K1/MAP2K2/KRAS/CD72/SYK/SOS2/PIK3AP1/VAV1/IFITM1/RAC2/BTK/LILRB2/PIK3CD/CHUK/NFKBIE/LILRB1/INPPL1/DAPP1/NFATC3/CD22/PTPN6/LILRB3/INPP5D/PLCG2/RASGRP3/LILRB5/NFATC2/PIK3R2/CD79B/NFATC1	4.26008151259166
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	38/2914	70/9376	1.74668104716149	HLA-B/HLA-E/HLA-A/ACTG1/FYN/SGCB/DTNA/HLA-C/HLA-DPB1/HLA-DQA2/HLA-DRA/SGCE/HLA-F/HLA-DPA1/ABL1/EIF4G3/HLA-DMB/HLA-DMA/HLA-DQA1/SNTB2/CXADR/HLA-DRB1/CD86/ITGB2/HLA-DQB1/BID/CD40/ABL2/SNTA1/HLA-DOA/SSPN/RAC2/ICAM1/ITGAL/CAV1/SNTB1/EIF4G2/HLA-DRB5	4.2106540294074
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	59/2914	122/9376	1.55603812009856	FYN/PIK3R1/AKT3/MAPK14/NCK1/PPP2R3C/PAK3/PTPN11/RELA/PPP3CC/PPP3CB/PPP2R5E/JUN/CDK4/IKBKG/PDPK1/PIK3CA/PPP2R5B/MALT1/AKT2/MAPK1/RAF1/PPP2CA/IKBKB/MAPK10/NFKB1/MAP2K1/MAPK8/PPP2CB/MAP2K2/KRAS/MAP3K7/PPP2R2D/PTPRC/LCP2/SOS2/MAP2K7/NCK2/CD4/VAV1/PAK2/PPP2R3A/PIK3CD/CHUK/NFKBIE/RHOA/IL10/PLCG1/NFATC3/PTPN6/LAT/MAPK12/MAPK11/CD247/NFATC2/CD3E/PIK3R2/ZAP70/NFATC1	4.15113320114149
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	37/2914	68/9376	1.75073680810691	PIM1/PIK3R1/AKT3/STAT3/RELA/IKBKG/PML/PIK3CA/RARA/STAT5B/AKT2/MAPK1/RAF1/IKBKB/SPI1/NFKB1/MAP2K1/ARAF/MAP2K2/TCF7L2/KRAS/RUNX1T1/ZBTB16/RPS6KB1/FCGR1A/BAD/SOS2/CD14/RUNX1/PER2/PIK3CD/ITGAM/CHUK/MYC/STAT5A/MTOR/PIK3R2	4.1721596027077
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	22/2914	34/9376	2.08195728531632	RORB/FBXW11/FBXL3/CSNK1E/PRKAG1/CSNK1D/PRKAG2/CLOCK/PRKAA1/CRY2/CREB1/RORA/CRY1/NFIL3/PER1/NR1D1/PER2/NR1D2/PRKAB1/NPAS2/PER3/PRKAA2	4.24401175058492
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	39/2914	73/9376	1.71897594042929	GADD45G/PIK3R1/AKT3/STAT3/KIF5B/EGFR/POLK/PRKCA/RB1/CDK4/PDPK1/PIK3CA/STAT5B/AKT2/MAPK1/RAF1/MAP2K1/ARAF/MAP2K2/RASSF1/KRAS/RXRB/STK4/BAD/SOS2/KIF5A/DDB2/PIK3CD/FOXO3/CDKN1A/PLCG1/STAT5A/RASSF5/GADD45A/JAK3/PLCG2/KIF5C/GADD45B/PIK3R2	4.14105703589305
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	21/2914	32/9376	2.11153054221002	GABARAPL1/GABARAP/WIPI1/ATG7/GABARAPL2/BECN1/ULK2/ATG5/ATG4A/PPP2CA/ATG4B/WIPI2/PPP2CB/ATG13/ATG16L1/PIK3C3/ATG4D/ATG2B/PIK3R4/MTOR/ATG2A	4.22938197374752
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	77/2914	170/9376	1.45737009972143	NFE2L2/WNT4/GSTT1/ACTG1/GADD45G/WNT5A/PIK3R1/AKT3/IGF1R/GSTM3/WNT5B/TGFBR1/SMARCE1/TXNRD2/PBRM1/EGFR/TGFBR2/POLK/MGST1/BCL2L1/WNT9A/SMARCC2/PRKCA/RB1/SHC2/CDK4/WNT2/KEAP1/PIK3CA/SMARCD1/SMAD2/APC/AKT2/MAPK1/RAF1/WNT6/FZD2/SHC1/MAP2K1/SMAD4/ARAF/MAP2K2/TCF7L2/KRAS/TXNRD1/SMAD3/RPS6KB1/BAD/DVL2/TGFB2/SOS2/CSNK1A1/SMARCD3/PHF10/GSTO1/DDB2/PIK3CD/ELK1/CDKN1A/FZD3/WNT3/LRP6/MYC/PLCG1/FZD10/MTOR/GADD45A/FZD4/PLCG2/FZD1/GADD45B/TXNRD3/TGFB3/FZD8/SHC3/PIK3R2/FRAT1	4.04113798725505
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	36/2914	66/9376	1.75503837274599	IFNGR2/HLA-DPB1/HLA-DQA2/HLA-DRA/STAT1/STAT3/HLA-DPA1/MAF/IFNGR1/HLA-DMB/IL4R/HLA-DMA/HLA-DQA1/RELA/JUN/SMAD2/HLA-DRB1/IL18/NFKB1/RORA/HLA-DQB1/SMAD3/STAT6/TGFB2/TLR4/HLA-DOA/TLR5/TLR2/IL2RG/IL10/IL12RB1/IL18R1/TGFB3/STAT4/HLA-DRB5/NFATC1	4.13345378597657
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	67/2914	144/9376	1.49706398230763	C3/FOXO1/MAP3K5/ALDH9A1/AKT3/MAPK14/TNFRSF1A/C2/C1QB/FADD/TRADD/C1QA/FAS/MYD88/ACACB/IL17RC/RELA/PRKAG1/PRKAG2/IKBKG/C1QC/LY96/C3AR1/PRKAA1/AKT2/LPIN1/IKBKB/MAPK10/CAMKK2/LPIN2/NFKB1/MAPK8/IRAK1/ADH1B/ACADM/TCF7L2/MAP3K7/CPT1C/TRAF3/ALDH3A2/IRAK4/PPARA/TLR4/MLYCD/MAP2K7/CD14/TAB2/RIPK1/MAP2K3/TRAF6/NOX4/LPIN3/MAP2K4/CHUK/FOXO3/TICAM1/PRKAB1/C5AR1/ADH5/CPT1A/IKBKE/SCD5/TAB3/MAPK12/MAPK11/C5/PRKAA2	4.03638494940879
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	38/2914	71/9376	1.72207990565217	JAM2/MAPK14/TJP1/ATP6V1D/LYN/ATP6V0A1/ATP6V0D1/EGFR/ADAM10/PTPN11/RELA/SRC/JUN/IKBKG/ATP6V0E1/ATP6V1H/IKBKB/CSK/MAPK10/ATP6V1C1/NFKB1/MAPK8/TCIRG1/ATP6V1G1/ATP6AP1/ATP6V0B/ATP6V1B2/MAP2K4/CHUK/PLCG1/NOD1/HBEGF/PLCG2/MAPK12/ATP6V1E2/MAPK11/ATP6V1G2/CCL5	4.10112663924645
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	71/2914	155/9376	1.47385480549959	WNT4/RAP1B/WNT5A/KCNK3/ADCY1/PRKACB/GNAI2/WNT5B/PDE8B/KMT2A/CREB3/CREB3L2/RAP1A/EGFR/CREB3L1/CDKN2B/WNT9A/RB1/ADCY3/PDE8A/CDK4/WNT2/APC/AIP/MAPK1/ATF2/ATF6B/ITPR2/CREB5/CREB1/WNT6/FZD2/USP8/PRKACA/MAP2K1/CDKN1B/MAP2K2/TCF7L2/NCEH1/SCARB1/GNA11/ADCY7/DVL2/AGTR1/STAR/PBX1/GNAQ/WDR5B/RBBP5/CACNA1G/CAMK2D/CDKN2C/ARMC5/AHR/CDKN1A/FZD3/WNT3/SP1/PLCB2/ADCY9/AGT/POMC/FZD10/CACNA1C/RASD1/FZD4/FZD1/CACNA1H/KMT2D/FZD8/ADCY6	3.99456104494067
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	37/2914	69/9376	1.72536381088797	FYN/PIK3R1/AKT3/MAPK14/LYN/PRKCA/PDPK1/PIK3CA/AKT2/MAPK1/RAF1/MAPK10/ALOX5/MAP2K1/MAPK8/MAP2K2/KRAS/SYK/LCP2/GAB2/ALOX5AP/SOS2/MAP2K7/VAV1/MAP2K3/RAC2/BTK/PIK3CD/MAP2K4/FCER1G/PLCG1/LAT/INPP5D/PLCG2/MAPK12/MAPK11/PIK3R2	4.06090198990838
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	34/2914	62/9376	1.76447406292204	FOXO1/IRS2/IRS1/PIK3R1/AKT3/IGF1R/ADCY1/INSR/PRKACB/CAT/SOD2/PRKAG1/ADCY3/PRKAG2/PIK3CA/ATG5/PRKAA1/AKT2/PRKACA/KRAS/RPS6KB1/ADCY7/IGF1/CRYAB/PIK3CD/FOXO3/PRKAB1/ADCY9/HSPA1A/MTOR/HSPA6/ADCY6/PIK3R2/PRKAA2	4.05543475072464
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	58/2914	122/9376	1.52966459263927	CAB39L/FOXO1/IRS2/IRS1/RHEB/PIK3R1/AKT3/IGF1R/INSR/CREB3/CREB3L2/PPP2R3C/ACACB/CREB3L1/CAB39/RAB11B/ULK1/PRKAG1/RAB14/PPP2R5E/FBP1/PRKAG2/PDPK1/TBC1D1/PIK3CA/PRKAA1/PPP2R5B/AKT2/PPP2CA/CREB5/CREB1/CAMKK2/STK11/PPP2CB/MAP3K7/G6PC3/CPT1C/PPP2R2D/RPS6KB1/CD36/MLYCD/PFKM/PFKFB3/IGF1/PPP2R3A/PIK3CD/FOXO3/LEPR/PRKAB1/CRTC2/CPT1A/MTOR/TSC2/SCD5/LIPE/PFKFB2/PIK3R2/PRKAA2	3.95424017976356
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	33/2914	60/9376	1.76966369251887	SPHK1/VEGFA/PIK3R1/AKT3/MAPK14/SH2D2A/MAPKAPK2/PRKCA/PPP3CC/PPP3CB/SRC/SHC2/KDR/MAPKAPK3/PIK3CA/PTK2/AKT2/MAPK1/RAF1/MAP2K1/MAP2K2/KRAS/BAD/RAC2/PIK3CD/HSPB1/SPHK2/PLCG1/PLCG2/MAPK12/MAPK11/NFATC2/PIK3R2	4.01613978460791
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	70/2914	154/9376	1.46253197728833	MYL9/ACTG1/MYL6/ROCK2/NPR1/RGS2/MAPK7/CALM2/CAMK1/ADCY1/PRKACB/GNAI2/CACNB3/MYLK/EGFR/CACNA2D1/PRKCA/PPP3CC/PPP3CB/SRC/PRKAG1/CACNB2/JUN/ADCY3/PRKAG2/OXT/NFATC4/PRKAA1/MAPK1/RAF1/CD38/ITPR2/CAMK1D/CAMKK2/PRKACA/MYL6B/MAP2K1/MAP2K2/KRAS/PPP1R12A/ADCY7/GNAO1/ROCK1/GNAQ/OXTR/PPP1R12B/CAMK2D/NPR2/MAP2K5/ELK1/CDKN1A/RHOA/MEF2C/PRKAB1/PIK3R5/CACNA2D4/PLCB2/NFATC3/ADCY9/CACNB1/KCNJ5/CACNA1C/KCNJ12/PIK3CG/NFATC2/ADCY6/KCNJ2/PRKAA2/GUCY1A2/NFATC1	3.8863015852608
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	29/2914	51/9376	1.8295988264901	ACTG1/TJP1/ATP6V1D/PRKACB/ATP6V0A1/ATP6V0D1/PRKCA/ARF1/ADCY3/ATP6V0E1/ATP6V1H/SEC61A1/SEC61B/ATP6V1C1/PRKACA/TCIRG1/ATP6V1G1/ATP6AP1/ATP6V0B/ATP6V1B2/PLCG1/ADCY9/SLC12A2/SEC61A2/KDELR1/PLCG2/ATP6V1E2/SEC61G/ATP6V1G2	3.98910742589728
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	48/2914	98/9376	1.5759528245066	PIP5K1C/PIK3R1/ITPK1/CALM2/PLCD3/PI4K2A/CDIPT/PRKCA/PLCD1/MTMR6/INPP1/ITPKC/PIK3CA/DGKH/ITPR2/SACM1L/PIP4K2A/DGKE/PPIP5K2/IP6K3/INPP4B/IP6K2/MTMR3/PIP4K2B/MTMR14/IP6K1/PIK3C3/MTMR2/PIK3CD/OCRL/PI4KB/INPP4A/DGKA/PLCG1/INPPL1/ITPKB/PLCB2/PLCE1/PIKFYVE/SYNJ2/PIP5K1B/INPP5D/MTM1/PLCG2/INPP5E/ITPKA/DGKD/PIK3R2	3.84874999418408
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	48/2914	98/9376	1.5759528245066	SPHK1/CFL2/GSN/MARCKS/PIP5K1C/MARCKSL1/PIK3R1/AKT3/PLD1/LYN/FCGR3A/ASAP2/PRKCA/BIN1/WASF2/LIMK1/PIK3CA/MYO10/AKT2/CRK/MAPK1/RAF1/WASF1/MAP2K1/PTPRC/RPS6KB1/SYK/GAB2/FCGR1A/FCGR2A/CFL1/AMPH/VAV1/RAC2/PIK3CD/DOCK1/SPHK2/WAS/HCK/WASF3/PLCG1/INPPL1/PIP5K1B/ARPC2/LAT/INPP5D/PLCG2/PIK3R2	3.84874999418408
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	55/2914	116/9376	1.52557214872317	RAP1B/THY1/MYL9/ACTG1/CD99/ROCK2/MSN/JAM2/PIK3R1/MAPK14/VCAM1/CXCL12/GNAI2/VCL/MMP2/RAP1A/BCAR1/PTPN11/PRKCA/PIK3CA/ARHGAP5/ITGB2/PTK2/NCF2/CD99L2/ARHGAP35/CLDN10/MYL5/CXCR4/SIPA1/MMP9/ROCK1/VAV1/CLDN23/ITGB1/RAC2/PIK3CD/ITGAM/CYBB/RHOA/ICAM1/ITGA4/PLCG1/ITGAL/MYL12B/RASSF5/CYBA/PLCG2/CLDN12/MAPK12/MAPK11/CLDN15/PIK3R2/RHOH/TXK	3.82474758644949
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	48/2914	99/9376	1.56003410910755	PDGFRA/PDGFRB/PDGFD/PIP5K1C/RHEB/PIK3R1/AKT3/PLD1/CHPT1/PCYT1A/EGFR/PRKCA/GPCPD1/JUN/WASF2/PDGFC/PDPK1/PIK3CA/HIF1A/AKT2/DGKH/MAPK1/RAF1/MAPK10/WASF1/MAP2K1/MAPK8/SLC22A4/MAP2K2/KRAS/DGKE/RPS6KB1/SOS2/CHKB/RALGDS/RAC2/PIK3CD/WAS/PDGFA/DGKA/WASF3/SP1/PLCG1/MTOR/TSC2/PIP5K1B/DGKD/PIK3R2	3.7616227015293
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	43/2914	87/9376	1.59029339139627	GADD45G/PIK3R1/AKT3/TGFBR1/BCL2/EGFR/TGFBR2/POLK/JUN/PIK3CA/SMAD2/APC/AKT2/RALA/MAPK1/RAF1/MAPK10/MAP2K1/MAPK8/SMAD4/ARAF/MAP2K2/TCF7L2/KRAS/SMAD3/RPS6KB1/APPL1/BAD/TGFB2/SOS2/BCL2L11/RALGDS/DDB2/RAC2/PIK3CD/CDKN1A/RHOA/MYC/MTOR/GADD45A/GADD45B/TGFB3/PIK3R2	3.71441137865737
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	73/2914	166/9376	1.41495563585846	IRS2/MYL9/IRS1/ADRA2C/ROCK2/NPR1/RGS2/AKT3/CALM2/ADCY1/ATP2B4/INSR/GNAI2/BDKRB2/MEF2A/TRPC6/EDNRA/CREB3/CREB3L2/MYLK/EDNRB/CREB3L1/ATP2A2/PPP3CC/PPP3CB/ADCY3/GNA13/NFATC4/ADORA1/GTF2I/AKT2/MAPK1/ATF2/RAF1/ATF6B/ITPR2/CREB5/CREB1/MEF2D/MAP2K1/MAP2K2/KCNMB1/GNA11/PPP1R12A/BAD/ADCY7/SLC8A1/ROCK1/AGTR1/GNAQ/NPR2/PLN/ATP1B3/RHOA/MEF2C/PIK3R5/ATP2B1/KCNJ8/PLCB2/SRF/NFATC3/ADCY9/CACNA1C/ADRB3/PRKG1/PIK3CG/PDE3A/PDE3B/NFATC2/ADCY6/PDE5A/GUCY1A2/NFATC1	3.62220337987014
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	46/2914	95/9376	1.5579814326482	CTSK/VEGFA/IL15/HLA-DPB1/HLA-DQA2/HLA-DRA/ATP6V1D/CXCL12/HLA-DPA1/HLA-DMB/HLA-DMA/ATP6V0A1/ATP6V0D1/HLA-DQA1/TNFSF13B/JUN/ATP6V0E1/ATP6V1H/HLA-DRB1/CD86/ITGB2/IL18/CSF1/ATP6V1C1/HLA-DQB1/TCIRG1/ATP6V1G1/IL11/ATP6AP1/ACP5/TGFB2/TLR4/MMP1/ATP6V0B/HLA-DOA/ATP6V1B2/TLR2/ICAM1/ITGAL/MMP3/TEK/ATP6V1E2/TGFB3/ATP6V1G2/HLA-DRB5/CCL5	3.67054961653957
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	66/2914	148/9376	1.43486245339368	WNT4/GADD45G/ESR1/WNT5A/PIK3R1/AKT3/IGF1R/PGR/FGF2/WNT5B/FGF7/EGFR/POLK/WNT9A/RB1/SHC2/JUN/DLL1/CDK4/WNT2/PIK3CA/APC/AKT2/MAPK1/RAF1/WNT6/FZD2/NFKB2/SHC1/MAP2K1/ARAF/MAP2K2/TCF7L2/KRAS/RPS6KB1/NOTCH1/DVL2/SOS2/NCOA1/CSNK1A1/NOTCH2/IGF1/DDB2/PIK3CD/CDKN1A/FZD3/WNT3/FGF10/SP1/LRP6/MYC/NOTCH3/HES1/FZD10/MTOR/NOTCH4/GADD45A/FZD4/FZD1/GADD45B/HEYL/FZD8/SHC3/PIK3R2/FRAT1/JAG1	3.58076575595108
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	50/2914	106/9376	1.51772186322373	PLAT/FOXO1/PDGFRA/PDGFRB/PDGFD/ZEB1/PIK3R1/AKT3/IGF1R/PLAU/CREB3/CREB3L2/BCL2/EGFR/CREB3L1/CREBBP/RELA/RB1/PDGFC/IKBKG/PDPK1/PIK3CA/AKT2/MAPK1/RAF1/IKBKB/CREB5/CREB1/NFKB1/MAP2K1/CDKN1B/HSP90B1/ARAF/MAP2K2/TCF7L2/KRAS/AR/IL1R2/BAD/SOS2/MMP9/IGF1/PIK3CD/CHUK/PDGFA/CDKN1A/FOLR2/MMP3/MTOR/PIK3R2	3.59961875645247
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	37/2914	73/9376	1.63082332809959	MDFIC/MAP1B/BICD1/MAP1A/AFF4/MX2/SERINC3/CDK9/SAMHD1/MX1/CREBBP/NELFE/HGS/RANBP2/PDCD6IP/FEZ1/CHMP4A/VPS4B/ELL2/MAP1S/VPS4A/CHMP4B/TSG101/BICD2/CHMP6/CXCR4/NELFB/CCNT2/SUPT4H1/PIN1/ELL/CPSF7/CD4/MLLT3/APOBEC3G/BST2/KAT2B	3.63332795207653
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	39/2914	78/9376	1.60878517501716	C3/CFL2/SERPING1/MAPK14/C1S/CALM2/C2/GNAI2/C1QB/C1QA/MYD88/C1R/RELA/CASP1/JUN/C1QC/LY96/ITGB2/MAPK1/MAPK10/NFKB1/MAPK8/IRAK1/PYCARD/IRAK4/TLR4/CFL1/CD14/TRAF6/ITGB1/ITGAM/IRF8/TICAM1/RHOA/IL10/NOD1/MAPK12/MAPK11/C5	3.62546347004141
Human Diseases	Cancer: specific types	hsa05214	Glioma	38/2914	76/9376	1.60878517501716	GADD45G/PDGFRA/PDGFRB/PIK3R1/AKT3/IGF1R/CALM2/CAMK1/EGFR/POLK/PRKCA/RB1/SHC2/CDK4/PIK3CA/AKT2/MAPK1/RAF1/CAMK1D/SHC1/MAP2K1/ARAF/MAP2K2/KRAS/SOS2/CAMK2D/IGF1/DDB2/PIK3CD/PDGFA/CDKN1A/PLCG1/MTOR/GADD45A/PLCG2/GADD45B/SHC3/PIK3R2	3.57829651114484
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	64/2914	144/9376	1.43003126668192	WNT4/LEFTY2/ID4/MEIS1/WNT5A/TBX3/PIK3R1/AKT3/MAPK14/IGF1R/STAT3/INHBB/FGF2/WNT5B/PCGF5/IL6ST/JAK1/SMAD5/PCGF2/BMPR2/SMAD9/ACVR1/WNT9A/SKIL/WNT2/PIK3CA/SMAD2/APC/AKT2/MAPK1/BMI1/RAF1/SMARCAD1/WNT6/FZD2/BMP4/SMAD1/MAP2K1/KLF4/SMAD4/MAP2K2/BMPR1A/KRAS/SMAD3/REST/JAK2/DVL2/INHBA/IGF1/ACVR1B/PIK3CD/FZD3/WNT3/MYC/FZD10/ACVR2A/FZD4/JAK3/FZD1/MAPK12/MAPK11/FZD8/PIK3R2/LIF	3.49204889992577
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	18/2914	29/9376	1.99711263105578	WTIP/LATS2/CSNK1E/DCHS1/MOB1A/YAP1/NF2/RASSF1/SAV1/TEAD2/RASSF4/FAT4/MOB1B/FRMD6/WWTR1/AJUBA/RASSF2/LATS1	3.6112206940056
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	36/2914	72/9376	1.60878517501716	MAPK14/FADD/TRADD/AZI2/TANK/RELA/ZNFX1/CYLD/IKBKG/ATG5/DHX58/SIKE1/IKBKB/ADAR/MAPK10/NFKB1/MAPK8/TRIM25/OTUD5/MAP3K7/TRAF3/PIN1/CXCL10/IRF7/MAVS/RIPK1/TRAF6/CHUK/RNF125/IFIH1/IKBKE/CASP10/NLRX1/MAPK12/MAPK11/TBKBP1	3.48210931138206
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	11/2914	15/9376	2.35955159002517	ST3GAL5/ST6GALNAC6/HEXA/GLB1/B3GALT4/ST6GALNAC4/SLC33A1/ST6GALNAC5/ST3GAL2/ST3GAL1/ST6GALNAC3	3.53856464580088
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	42/2914	89/9376	1.51840398540945	TUBA1A/HTR2B/PDGFRA/GJA1/PDGFRB/PDGFD/LPAR1/MAPK7/TJP1/ADCY1/PRKACB/GNAI2/EGFR/TUBA3E/MAP3K2/PRKCA/SRC/CSNK1D/ADCY3/PDGFC/MAPK1/RAF1/ITPR2/TUBB2A/PRKACA/MAP2K1/MAP2K2/KRAS/GNA11/ADCY7/SOS2/GNAQ/MAP2K5/PDGFA/PLCB2/ADCY9/TUBB2B/TUBA3D/PRKG1/TUBA4A/ADCY6/GUCY1A2	3.29968549212243
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	67/2914	156/9376	1.38190521443782	CD81/PIK3R1/CFLAR/AKT3/STAT1/IFNAR1/TNFRSF1A/STAT3/FADD/MX2/TRADD/FAS/JAK1/MX1/EGFR/RELA/STAT2/RB1/RNASEL/OAS1/CDK4/IKBKG/EIF2AK2/OAS2/PIK3CA/AKT2/MAPK1/RAF1/PPP2CA/IKBKB/YWHAQ/NFKB1/MAP2K1/PPP2CB/ARAF/PIAS1/MAP2K2/KRAS/BID/CLDN10/NR1H3/SCARB1/PPP2R2D/IFIT1/TRAF3/BAD/PPARA/SOS2/CXCL10/IRF7/MAVS/CLDN23/RIPK1/IRF9/TRAF6/SOCS3/PIK3CD/CHUK/RSAD2/CDKN1A/TICAM1/MYC/IKBKE/CLDN12/TYK2/CLDN15/PIK3R2	3.2299764947643
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	67/2914	157/9376	1.37310327039681	WNT4/ACTG1/SERPINE1/WNT5A/WTIP/WNT5B/TGFBR1/NKD2/FBXW11/TGFBR2/BMPR2/WNT9A/LATS2/BIRC2/SNAI2/CSNK1E/CSNK1D/WNT2/MOB1A/SMAD2/APC/YAP1/ITGB2/PPP2CA/YWHAQ/WNT6/NF2/FZD2/BMP4/SMAD1/PPP2CB/SMAD4/RASSF1/TCF7L2/BMPR1A/PPP2R2D/SMAD3/SAV1/PRKCI/DVL2/TGFB2/CCND2/BIRC3/TEAD2/MOB1B/TP53BP2/FRMD6/GLI2/GDF7/PARD6G/WWTR1/AJUBA/FZD3/WNT3/MYC/DLG3/FZD10/CRB2/LATS1/FZD4/BMP2/FZD1/SMAD7/DLG4/TGFB3/PARD6A/FZD8	3.16580316987423
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	68/2914	160/9376	1.36746739876458	SDC2/HLA-B/HLA-E/VCAN/HLA-A/ITGB8/CD99/HLA-C/HLA-DPB1/HLA-DQA2/HLA-DRA/JAM2/VCAM1/PTPRM/HLA-F/ITGAV/HLA-DPA1/SDC3/HLA-DMB/HLA-DMA/NLGN4X/GLG1/HLA-DQA1/CD58/SELPLG/CDH2/CXADR/ICAM2/HLA-DRB1/NRXN1/CD86/ITGB2/NLGN2/NRXN2/HLA-DQB1/CD99L2/CLDN10/ALCAM/PTPRC/NEO1/CDH3/NEGR1/PTPRD/CD40/CNTN1/SLITRK4/CD226/HLA-DOA/CD4/CLDN23/ITGB1/NLGN1/ITGAM/CADM1/NCAM2/ICAM1/NCAM1/SPN/SIGLEC1/ITGA4/ITGAL/CD2/CD22/NFASC/CLDN12/CLDN15/CNTNAP1/HLA-DRB5	3.14814341383681
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	19/2914	33/9376	1.85254050456521	STX4/SNAP23/VAMP3/STX7/VAMP5/STX5/STX18/VAMP2/STX2/USE1/GOSR2/GOSR1/STX8/VAMP4/VTI1A/STX16/STX11/STX1A/STX3	3.29439562300819
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	43/2914	93/9376	1.4876938177578	RAP1B/MYL9/ACTG1/FYN/ROCK2/IGF1R/PTPRM/TJP1/INSR/TGFBR1/VCL/RAP1A/EGFR/TGFBR2/CREBBP/SORBS1/SRC/CCM2/SNAI2/WASL/WASF2/CSNK2A1/PTPN1/MAPK1/WASF1/KRIT1/SMAD4/TCF7L2/MAP3K7/MYL5/SMAD3/ROCK1/SMURF2/BAIAP2/RAC2/WAS/RHOA/WASF3/MYL12B/PTPN6/PTPRJ/RADIL/NLK	3.17388717490278
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	41/2914	88/9376	1.49909527672053	F3/PLAT/C3/CFH/CFI/F2R/SERPING1/CD59/SERPINE1/CLU/PROS1/C1S/PLAU/C2/PLAUR/C1QB/BDKRB2/VTN/C1QA/A2M/C1R/SERPINB2/BDKRB1/C1QC/MASP1/C3AR1/ITGB2/CD46/SERPINA1/CFD/VSIG4/CR1/ITGAM/ITGAX/C5AR1/F2RL3/FGG/F12/C5/F8/SERPINF2	3.1587163446137
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	34/2914	70/9376	1.56281988430238	RAP1B/VEGFA/EGLN2/PIK3R1/AKT3/RAP1A/PAK3/ETS1/PTPN11/CREBBP/JUN/TFE3/PIK3CA/HIF1A/EGLN1/CUL2/AKT2/CRK/MAPK1/RAF1/PRCC/MAP2K1/ARAF/MAP2K2/KRAS/BAD/TGFB2/SOS2/PAK2/PIK3CD/CDKN1A/ARNT2/TGFB3/PIK3R2	3.17383148089455
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	32/2914	65/9376	1.58403463386305	KCNK3/ADCY1/PRKACB/PDE8B/CREB3/CREB3L2/CREB3L1/ADCY3/PDE8A/ATF2/ATF6B/ITPR2/CREB5/CREB1/PRKACA/NCEH1/SCARB1/GNA11/ADCY7/AGTR1/STAR/PBX1/GNAQ/CACNA1G/SP1/PLCB2/ADCY9/AGT/POMC/CACNA1C/CACNA1H/ADCY6	3.17280990065052
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	39/2914	83/9376	1.51187040543781	PHC2/UBE2D1/PHF1/PCGF5/PCGF2/PHF19/YAF2/CREBBP/MAX/SFMBT2/CBX6/BMI1/E2F6/DCAF7/EZH1/RING1/USP16/KDM2A/AUTS2/ASXL2/PHC3/CBX7/FBRS/ASXL1/WDR5B/MGA/SCMH1/SCML1/LCOR/L3MBTL3/OGT/FBRSL1/UBE2D3/FOXK1/MBD5/CBX8/ASXL3/SCML2/YY2	3.14534315460864
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	74/2914	178/9376	1.33764160619404	MCC/WNT4/TLE2/ROCK2/WNT5A/ROR2/PRKACB/WNT5B/NKD2/DKK1/FBXW11/CBY1/RSPO3/CREBBP/CTBP2/DAAM1/WNT9A/PRKCA/PPP3CC/BAMBI/PPP3CB/PRICKLE2/CSNK1E/LZTS2/JUN/WNT2/APC/NFATC4/CSNK2A1/MMP7/MAPK10/WNT6/FZD2/PRKACA/MAPK8/SMAD4/TCF7L2/TLE6/MAP3K7/TBL1X/SMAD3/RYK/PRICKLE1/DVL2/CHD8/CCND2/CSNK1A1/TLE4/PSEN1/CAMK2D/RAC2/RHOA/FOSL1/FZD3/WNT3/LRP6/RSPO1/MYC/PLCB2/INVS/NFATC3/FZD10/FZD4/FZD1/FZD8/NFATC2/PORCN/CELSR1/NLK/VANGL2/ROR1/FRAT1/ANKRD6/NFATC1	3.05398001819086
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	22/2914	41/9376	1.72650116343305	VEGFA/THBS1/MMP2/DAPK3/EGFR/RB1/SRC/CDK4/MAPK1/RAF1/MAP2K1/ARAF/MAP2K2/RASSF1/KRAS/MMP1/MMP9/DAPK1/CDKN1A/MYC/HBEGF/DAPK2	3.13053105538567
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	46/2914	103/9376	1.43697316603474	LAMA4/IL1R1/PIK3R1/COL4A4/ADCY1/LAMB2/PRKACB/VCL/LAMC1/RELA/PRKCA/SERPINB6/RAB7A/RAB5C/RAB5A/PIK3CA/ITGB2/PTK2/CD1D/PRKACA/NFKB1/GNA11/LAMA3/IL1R2/TGFB2/TLR4/RAB5B/CD14/GNAQ/GNA15/COL4A3/COL4A6/PIK3CD/ITGAM/SERPINB10/TLR2/HSPB1/LAMB1/IL10/PLCB2/LAMC3/LAMB3/TGFB3/GNA14/PIK3R2/GNAL	2.99440256316124
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	57/2914	133/9376	1.37895872144328	GNG4/MAOB/AKT3/MAPK14/CALM2/PRKACB/MAOA/GNAI2/KIF5B/GNG11/CREB3/CREB3L2/PPP2R3C/GNB5/CREB3L1/PRKCA/PPP3CC/PPP3CB/PPP2R5E/GNB2/CLOCK/PPP2R5B/AKT2/ATF2/PPP2CA/ATF6B/ITPR2/CREB5/MAPK10/CREB1/PRKACA/MAPK8/PPP2CB/GNB1/GNG2/PPP2R2D/GSK3A/KIF5A/GRIA3/GNAO1/GNB4/GRIA4/GNAQ/CAMK2D/ARRB2/PPP2R3A/PLCB2/ARRB1/KCNJ5/CACNA1C/KIF5C/GNGT2/MAPK12/MAPK11/GNB3/CACNA1A/GNAL	2.95568525823613
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	59/2914	139/9376	1.36573129965485	CTSD/ESR1/GREB1/PIK3R1/AKT3/CALM2/PGR/ADCY1/PRKACB/GNAI2/CREB3/MMP2/CREB3L2/BCL2/EGFR/CREB3L1/SRC/SHC2/EBAG9/JUN/ADCY3/PIK3CA/RARA/AKT2/MAPK1/ATF2/RAF1/ATF6B/ITPR2/CREB5/CREB1/PRKACA/SHC1/MAP2K1/HSP90B1/MAP2K2/KRAS/FKBP5/KRT34/ADCY7/SOS2/MMP9/NCOA1/GNAO1/GNAQ/KRT10/GABBR1/PIK3CD/SP1/PLCB2/HBEGF/ADCY9/HSPA1A/POMC/KCNJ5/HSPA6/SHC3/ADCY6/PIK3R2	2.91709781983938
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	12/2914	19/9376	2.03214969475852	IDS/HEXA/NAGLU/GNS/SGSH/GLB1/HYAL2/GALNS/GUSB/HGSNAT/HPSE/ARSB	3.02411365564802
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	11/2914	17/9376	2.08195728531632	PAPSS2/MTR/TXNRD2/SEPHS1/PAPSS1/TXNRD1/SEPHS2/INMT/TXNRD3/SCLY/SEPSECS	2.99824271888756
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	56/2914	133/9376	1.35476646317234	HLA-B/HLA-E/HLA-A/IFNGR2/FYN/HLA-C/PIK3R1/IFNAR1/IFNGR1/FCGR3A/FAS/PTPN11/PRKCA/PPP3CC/PPP3CB/MICA/SHC2/ICAM2/PIK3CA/ITGB2/MAPK1/RAF1/SHC1/MAP2K1/ARAF/MAP2K2/KRAS/BID/CD48/SYK/LCP2/TYROBP/SOS2/HCST/VAV1/SH3BP2/RAC2/PIK3CD/LAT2/FCER1G/ICAM1/PLCG1/ITGAL/MICB/PTPN6/LAT/PLCG2/KLRC1/CD247/KLRC2/NFATC2/SHC3/KLRD1/PIK3R2/ZAP70/NFATC1	2.76699794985987
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	43/2914	98/9376	1.41179107195383	NPR1/KCNK3/CALM2/CAMK1/ADCY1/ATP2B4/PRKACB/CREB3/CREB3L2/CREB3L1/PRKCA/ADCY3/ATF2/ATF6B/ITPR2/CAMK1D/CREB5/CREB1/PRKACA/SCARB1/GNA11/ADCY7/AGTR1/STAR/DAGLB/GNAQ/CACNA1G/CAMK2D/PRKD2/PRKD1/ATP1B3/ATP2B1/PLCB2/ADCY9/AGT/POMC/NR4A2/KCNJ5/CACNA1C/DAGLA/LIPE/CACNA1H/ADCY6	2.75175468953569
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	41/2914	93/9376	1.41849875646674	MAPK14/MAPK7/CALM2/ADCY1/PLD1/PRKACB/MAP3K4/MMP2/MMP14/EGFR/MAP3K2/PRKCA/SRC/JUN/ADCY3/MAPK1/RAF1/ITPR2/MAP3K3/MAPK10/PRKACA/MAP2K1/MAPK8/MAP2K2/KRAS/GNA11/ADCY7/SOS2/MAP2K7/GNAQ/CAMK2D/MAP2K3/MAP2K4/ELK1/PLCB2/HBEGF/ADCY9/CACNA1C/MAPK12/MAPK11/ADCY6	2.72356914830156
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	81/2914	205/9376	1.27133267489161	C3/GSN/HLA-B/HLA-E/HLA-A/HLA-C/PIK3R1/STAT3/HLA-F/LYN/PRKACB/MAPKAPK2/TRADD/IL6ST/CREB3/CREB3L2/ATP6V0D1/JAK1/HDAC7/CREB3L1/SP100/CDKN2B/CREBBP/RELA/RBPJ/RB1/SRC/JUN/LTBR/GTF2A1/CDK4/IKBKG/EIF2AK2/PIK3CA/STAT5B/UBE3A/RBL2/GTF2E2/MAPK1/ATF2/CHD4/ATF6B/YWHAQ/CREB5/CREB1/NFKB2/PRKACA/NFKB1/MAD1L1/CDKN1B/SNW1/KRAS/HDAC3/GTF2H1/RASA2/SYK/VAC14/UBR4/TRAF3/BAD/CCND2/IRF7/IRF9/HDAC11/TRAF5/PIK3CD/GTF2E1/CDKN1A/RHOA/GTF2H2C/STAT5A/HDAC4/SRF/TBP/KAT2B/HDAC10/JAK3/HDAC6/HDAC9/TRAF1/PIK3R2	2.63765272293029
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	28/2914	59/9376	1.52698253899934	IRS2/IRS1/ABHD5/NPR1/PIK3R1/AKT3/ADCY1/INSR/PRKACB/GNAI2/PNPLA2/ADCY3/MGLL/PIK3CA/ADORA1/AKT2/PRKACA/ADCY7/PTGS1/PIK3CD/ADCY9/FABP4/ADRB3/LIPE/PRKG1/PDE3B/ADCY6/PIK3R2	2.72666082633697
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	28/2914	59/9376	1.52698253899934	GADD45G/PIK3R1/AKT3/ILK/EGFR/POLK/PDPK1/PIK3CA/APC/AKT2/MAPK1/RAF1/MAP2K1/ARAF/MAP2K2/TCF7L2/KRAS/BAD/SOS2/DDB2/PIK3CD/ELK1/FOXO3/CDKN1A/MYC/GADD45A/GADD45B/PIK3R2	2.72666082633697
Human Diseases	Immune disease	hsa05330	Allograft rejection	20/2914	39/9376	1.65003607694068	HLA-B/HLA-E/HLA-A/HLA-C/HLA-DPB1/HLA-DQA2/HLA-DRA/HLA-F/HLA-DPA1/HLA-DMB/FAS/HLA-DMA/HLA-DQA1/HLA-DRB1/CD86/HLA-DQB1/CD40/HLA-DOA/IL10/HLA-DRB5	2.7315743112685
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	25/2914	52/9376	1.54690882213188	NPC2/APOA1/APOE/LIPA/OSBPL5/TSPO/ABCA1/SOAT1/LPL/CYP27A1/LRPAP1/STARD3NL/LRP1/STARD3/APOC1/VAPA/NCEH1/SCARB1/SOAT2/CD36/STAR/APOC2/APOC3/CIDEB/LCAT	2.65559843148637
Human Diseases	Cancer: specific types	hsa05218	Melanoma	33/2914	73/9376	1.45451810344017	GADD45G/PDGFRA/PDGFRB/PDGFD/PIK3R1/AKT3/IGF1R/FGF2/FGF7/MITF/EGFR/POLK/RB1/PDGFC/CDK4/PIK3CA/AKT2/MAPK1/RAF1/MAP2K1/ARAF/MAP2K2/KRAS/BAD/IGF1/DDB2/PIK3CD/PDGFA/CDKN1A/FGF10/GADD45A/GADD45B/PIK3R2	2.61786978444349
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	29/2914	63/9376	1.48110381192056	WNT4/GADD45G/WNT5A/WNT5B/POLK/WNT9A/WNT2/APC/WNT6/FZD2/BMP4/TCF7L2/DVL2/GLI2/DDB2/CDKN1A/FZD3/WNT3/PTCH1/SMO/SUFU/FZD10/GADD45A/FZD4/BMP2/FZD1/GADD45B/FZD8/KIF7	2.5728306822958
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	43/2914	101/9376	1.36985668367798	WNT4/WNT5A/CALM2/ADCY1/PRKACB/GNAI2/WNT5B/CREB3/CREB3L2/MITF/EDNRB/CREB3L1/ASIP/CREBBP/WNT9A/PRKCA/ADCY3/WNT2/MAPK1/RAF1/CREB1/WNT6/FZD2/PRKACA/MAP2K1/MAP2K2/TCF7L2/KRAS/ADCY7/DVL2/GNAO1/GNAQ/CAMK2D/FZD3/WNT3/PLCB2/ADCY9/POMC/FZD10/FZD4/FZD1/FZD8/ADCY6	2.50948228395572
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	36/2914	82/9376	1.41259186099068	CTSB/CTSS/HLA-B/HLA-E/HLA-A/B2M/HLA-C/HLA-DPB1/HLA-DQA2/HLA-DRA/HLA-F/HLA-DPA1/HLA-DMB/TAP1/HLA-DMA/CD74/HLA-DQA1/TAPBPL/TAPBP/HLA-DRB1/CREB1/HLA-DQB1/IFI30/HLA-DOA/CD4/CIITA/LGMN/RFX5/HSPA1A/HSPA6/KLRC1/KLRC2/KLRD1/RFXAP/HSPA5/HLA-DRB5	2.51984126566818
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	89/2914	233/9376	1.22902901782427	SDC2/FBN1/LMOD1/ITGB5/PDLIM4/ZYX/FHL1/NID2/VCAN/MYL9/DCN/VIM/ACTG1/ITGB8/SGCB/PDLIM1/DTNA/PDLIM2/THBS1/SGCE/TMEM43/ITGAV/SPTAN1/COL4A4/SDC3/FBLN2/TPM2/VCL/SPTBN1/SYNE1/SYNPO2/TLN2/SUN2/TPM4/THBS3/CAPZA2/NID1/DAAM1/TLN1/SNTB2/COL6A3/TMOD1/TMOD3/ITGB3/FBLN1/CSRP1/FHL3/AGRN/PDLIM7/CAPZB/MYH11/ITGA3/PLEC/COL5A2/EMD/MYL5/ITGA1/DIAPH2/MYOM2/TMOD2/MYH9/TNNC2/COL5A3/SNTA1/BGN/ITGA2/AMPD3/COL4A3/SSPN/FMNL1/ITGB1/COL4A6/THBS2/ATP1B3/AMPD2/TNNT3/SUN1/FMNL3/ITGA4/ACTN2/FMNL2/LMNA/ENO2/COL24A1/SNTB1/CAPN3/ANK2/COMP/CKM	2.37722914638396
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	12/2914	21/9376	1.83861162859104	CHST3/CHST7/CSGALNACT2/CHST15/CHPF2/B3GALT6/DSE/CHSY1/CHST11/UST/CHST14/CHSY3	2.58342326782436
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	60/2914	150/9376	1.28702814001373	WNT4/GADD45G/WNT5A/PIK3R1/AKT3/FGF2/WNT5B/TGFBR1/FGF7/BCL2/EGFR/TGFBR2/POLK/CDKN2B/WNT9A/RB1/SHC2/WNT2/PIK3CA/SMAD2/APC/AKT2/MAPK1/RAF1/WNT6/FZD2/SHC1/MAP2K1/CDKN1B/SMAD4/ARAF/MAP2K2/TCF7L2/KRAS/RXRB/SMAD3/RPS6KB1/DVL2/TGFB2/SOS2/CSNK1A1/DDB2/PIK3CD/CDKN1A/FZD3/WNT3/FGF10/LRP6/MYC/FZD10/MTOR/GADD45A/FZD4/FZD1/GADD45B/TGFB3/FZD8/SHC3/PIK3R2/FRAT1	2.37963482584747
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	21/2914	44/9376	1.53565857615274	HLA-B/HLA-E/HLA-A/HLA-C/HLA-DPB1/HLA-DQA2/HLA-DRA/HLA-F/HLA-DPA1/HLA-DMB/FAS/HLA-DMA/HLA-DQA1/HLA-DRB1/CD86/HLA-DQB1/PTPRN2/HLA-DOA/PTPRN/ICA1/HLA-DRB5	2.39151974476687
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	47/2914	115/9376	1.31500701262272	GNG4/FYN/PIK3R1/AKT3/ADCY1/PRKACB/GNAI2/GNG11/CREB3/CREB3L2/BCL2/GNB5/CREB3L1/PRKCA/ADCY3/GNB2/PIK3CA/AKT2/MAPK1/ITPR2/CREB5/CREB1/PRKACA/MAP2K1/GNB1/GNG2/KRAS/GNA11/JAK2/ADCY7/GNAO1/GNB4/GNAQ/CAMK2D/PIK3CD/PIK3R5/PLCB2/ADCY9/CACNA1C/GNGT2/KCNJ12/PIK3CG/ADCY6/GNB3/KCNJ2/CACNA1A/PIK3R2	2.28237570209617
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	25/2914	55/9376	1.46253197728833	SPHK1/SPTLC2/CERS6/PSAP/HEXA/CERK/ARSA/DEGS1/CERS4/ACER3/CERS2/GLB1/ASAH1/SMPD1/SGPL1/SPTLC1/SAMD8/UGCG/SGMS1/SGMS2/KDSR/B4GALT5/GALC/SPHK2/GBA2	2.31014260144001
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	45/2914	110/9376	1.31627877955949	VEGFA/TIMP1/IFNGR2/EGLN2/SERPINE1/PIK3R1/AKT3/IGF1R/STAT3/INSR/IFNGR1/BCL2/EGFR/CREBBP/RELA/PRKCA/LTBR/PIK3CA/HIF1A/IL6R/EGLN1/CUL2/AKT2/MAPK1/NFKB1/MAP2K1/CDKN1B/MAP2K2/RPS6KB1/TLR4/PFKM/CAMK2D/PFKFB3/IGF1/PIK3CD/CYBB/CDKN1A/PLCG1/MTOR/ENO2/HK3/PLCG2/TEK/ANGPT2/PIK3R2	2.24061471597048
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	41/2914	99/9376	1.3325291348627	C3/CFH/CFI/HLA-DPB1/HLA-DQA2/HLA-DRA/C1S/C2/HLA-DPA1/C1QB/HLA-DMB/C1QA/FCGR3A/HLA-DMA/C1R/HLA-DQA1/SELPLG/FPR3/C1QC/MASP1/C3AR1/HLA-DRB1/ITGB2/HLA-DQB1/KRT34/CFD/FCGR1A/CAMP/FCGR2A/PTAFR/HLA-DOA/KRT10/ITGAM/ICAM1/IL10/ITGAL/C5AR1/FGG/C5/FPR1/HLA-DRB5	2.23352314131854
Human Diseases	Substance dependence	hsa05032	Morphine addiction	38/2914	91/9376	1.34360080550884	GNG4/GRK5/ADCY1/PRKACB/GNAI2/PDE8B/GNG11/GNB5/PDE4B/PRKCA/ADCY3/GABRA2/PDE8A/GNB2/ADORA1/PRKACA/GNB1/GNG2/GRK4/ADCY7/GNAO1/GNB4/GRK6/PDE4A/ARRB2/GABBR1/PDE10A/PDE7A/ARRB1/ADCY9/GABRE/KCNJ5/GNGT2/PDE3A/PDE3B/ADCY6/GNB3/CACNA1A	2.21172359193995
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	41/2914	100/9376	1.31920384351407	CD44/CD59/HLA-DPB1/HLA-DQA2/HLA-DRA/IL1R1/HLA-DPA1/HLA-DMB/IL4R/HLA-DMA/ANPEP/HLA-DQA1/ITGB3/CD37/IL6R/HLA-DRB1/CD38/CSF1/CD1D/HLA-DQB1/ITGA3/IL11/ITGA1/FCGR1A/IL1R2/CD36/CD14/CR1/HLA-DOA/CD4/ITGA2/EPOR/IL2RA/FLT3LG/ITGAM/ITGA4/THPO/CD2/CD22/CD3E/HLA-DRB5	2.15493749181392
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	18/2914	38/9376	1.52411227106889	NNMT/ENPP1/NT5E/BST1/AOX1/SIRT2/NAMPT/NT5C/CD38/NNT/NADK/NT5C2/SIRT6/NMNAT1/NUDT12/NMNAT2/SARM1/SIRT3	2.17388280098744
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	81/2914	217/9376	1.20102856383769	VEGFA/GSTT1/ESR1/PIK3R1/AKT3/STAT3/PGR/ADCY1/PRKACB/FGF2/GSTM3/GNAI2/KPNA3/RPS6KA3/CYP1B1/CREB3/FGF7/CREB3L2/BCL2/EGFR/CREB3L1/MGST1/RELA/PRKCA/RB1/SRC/JUN/ADCY3/DLL1/XIAP/PIK3CA/STAT5B/AIP/AKT2/MAPK1/ATF2/RAF1/ATF6B/CREB5/CREB1/PRKACA/NFKB1/MAP2K1/KLF4/HSP90B1/MAP2K2/KRAS/RXRB/KPNA6/KPNA1/RPS6KB1/AR/JAK2/BAD/ADCY7/PPARA/SOS2/VDR/NOTCH2/MIR29A/KPNA5/GSTO1/PAQR8/ARRB2/AHR/PIK3CD/FGF10/RPS6KA2/MYC/STAT5A/ARRB1/ADCY9/IKBKE/MTOR/CACNA1C/ADRB3/ADCY6/CACNA1A/PIK3R2/JAG1/EPHX2	2.01191923402906
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	12/2914	23/9376	1.67873235653964	B4GALT3/B4GALT2/POMGNT1/CHST10/POMGNT2/POMT2/FKTN/B3GALNT2/FKRP/ST3GAL3/B3GAT2/FUT4	2.18843644815843
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	20/2914	44/9376	1.46253197728833	MGAT2/MGAT4B/HEXA/B4GALT3/ALG2/MGAT1/B4GALT2/MAN1A1/MGAT4C/ALG1/RPN1/ALG14/FUT8/MAN1C1/ALG13/DAD1/ALG11/MAN2A2/ST3GAL3/OSTC	2.06503621059485
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	22/2914	50/9376	1.4157309540151	SDC2/CD81/THBS1/VCAM1/GYPC/MYD88/THBS3/ITGB2/LRP1/IL18/TGFB2/TLR4/CD36/CD40/CR1/THBS2/TLR2/ICAM1/IL10/ITGAL/TGFB3/COMP	1.97923149698561
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	19/2914	42/9376	1.45556753930124	SAT1/FTH1/MAP1LC3A/PRNP/SAT2/ATG7/SLC39A14/ACSL3/SLC3A2/ATG5/ACSL1/FTL/PCBP1/SLC40A1/MAP1LC3B/CYBB/GCLC/PCBP2/ACSL5	1.98696608166905
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	31/2914	75/9376	1.32992907801418	CD82/IGFBP3/CHEK2/GADD45G/AIFM2/TP53I3/THBS1/SERPINE1/FAS/BCL2/BCL2L1/SESN3/CDK4/ZMAT3/ZNF385A/BID/RCHY1/SESN1/CCNG2/GORAB/CCND2/ATM/IGF1/DDB2/RRM2B/ATR/CDKN1A/TSC2/GADD45A/PPM1D/GADD45B	1.92634175307801
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	8/2914	14/9376	1.83861162859104	CHST2/CHST1/B4GALT3/B4GALT2/ST3GAL2/FUT8/ST3GAL1/ST3GAL3	2.10856753129304
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	20/2914	45/9376	1.43003126668192	HLA-B/HLA-E/HLA-A/HLA-C/HLA-DPB1/HLA-DQA2/HLA-DRA/HLA-F/HLA-DPA1/HLA-DMB/FAS/HLA-DMA/HLA-DQA1/HLA-DRB1/CD86/HLA-DQB1/HLA-DOA/KLRC1/KLRD1/HLA-DRB5	1.94173129682582
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	17/2914	37/9376	1.47834313379955	GADD45G/NTRK1/POLK/TFG/MAPK1/MAP2K1/MAP2K2/TCF7L2/KRAS/RXRB/DDB2/TPR/CDKN1A/MYC/PAX8/GADD45A/GADD45B	1.95765948911576
Cellular Processes	Cell motility	hsa04814	Motor proteins	72/2914	194/9376	1.19414982063129	TUBA1A/MYL9/ACTG1/MYL6/DYNLT3/KIF1B/DCTN2/KIF13A/TPM2/KIF5B/DYNC2LI1/KIF16B/DYNC1LI1/DNALI1/ACTR1A/DYNC1H1/KLC1/TPM4/MYO5A/ACTR10/TUBA3E/DCTN6/MYO6/CAPZA2/MYO1E/HOOK3/DYNC2H1/MYO9B/KIF3B/KIFAP3/MYO1C/DNAL4/DYNC1LI2/MYO10/KIF1C/TUBB2A/CAPZB/ACTR1B/MYH11/MYL6B/DYNC1I2/DCTN1/MYO9A/MYL5/TUBE1/KIF3A/DYNLRB1/DNAL1/KIF13B/KIF5A/MYH9/TNNC2/MYO16/KIFC3/TUBG2/MYO1F/DCTN3/ACTA2/TNNT3/KLC2/MYL12B/TUBB2B/TUBA3D/MYO15B/KIF27/TUBD1/KIF5C/STARD9/TUBA4A/DYNLRB2/KIF7/MYO1D	1.83491583883607
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	24/2914	56/9376	1.37895872144328	MGAT2/MGAT4B/B4GALT3/ALG2/ALG5/MGAT1/B4GALT2/MAN1A1/DPM2/MGAT4C/ST6GAL2/ALG1/RPN1/ALG14/DPM3/FUT8/MAN1C1/ALG13/MGAT3/DAD1/DOLK/ALG11/MAN2A2/OSTC	1.90996275697683
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	21/2914	48/9376	1.40768702814001	ALDH9A1/ACAT1/ACAA1/HMGCL/AOX1/ACAA2/HIBCH/IVD/ACAD8/IL4I1/HADHB/ACADM/ACSF3/OXCT1/BCAT1/ALDH3A2/ABAT/ALDH6A1/HADHA/MCCC1/OXCT2	1.90151685030196
NA	NA	hsa03272	Virion - Hepatitis viruses	21/2914	48/9376	1.40768702814001	CD81/CD63/LAMP1/TGOLN2/LAMP2/EGFR/PDCD6IP/CHMP4A/VPS4B/CHMP1B/IST1/VPS4A/CHMP4B/TSG101/CHMP1A/CLDN10/SCARB1/CHMP7/CLDN23/CLDN12/CLDN15	1.90151685030196
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	15/2914	32/9376	1.50823610157859	TNFRSF1A/FADD/BCL2/BCL2L1/BECN1/BIRC2/XIAP/HTRA2/MAPK10/BOK/MAPK8/BID/BIRC6/BIRC3/BCL2L11	1.9338421435999
Human Diseases	Immune disease	hsa05310	Asthma	15/2914	32/9376	1.50823610157859	HLA-DPB1/PRG2/HLA-DQA2/HLA-DRA/HLA-DPA1/HLA-DMB/HLA-DMA/HLA-DQA1/HLA-DRB1/HLA-DQB1/CD40/HLA-DOA/FCER1G/IL10/HLA-DRB5	1.9338421435999
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	31/2914	76/9376	1.31243001119821	APOA1/LPL/ILK/ACAA1/SORBS1/ACSL3/CYP27A1/PDPK1/SCP2/ACSL1/ME3/ACADM/CPT1C/RXRB/NR1H3/SLC27A4/PPARA/MMP1/CD36/GK/SLC27A1/FABP3/APOC3/ME1/FABP5/CPT1A/SCD5/FABP4/ACSL5/ACOX2/OLR1	1.83639034740946
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	39/2914	99/9376	1.26752771364988	ITGB5/ACTG1/ITGB8/SGCB/DTNA/ACE/SGCE/ITGAV/CACNB3/TPM2/TPM4/CACNA2D1/ATP2A2/PRKAG1/CACNB2/SNTB2/PRKAG2/ITGB3/PRKAA1/ITGA3/EMD/ITGA1/TGFB2/SLC8A1/SNTA1/ITGA2/IGF1/SSPN/ITGB1/PRKAB1/ITGA4/CACNA2D4/CACNB1/AGT/LMNA/CACNA1C/TGFB3/SNTB1/PRKAA2	1.79692326697261
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	41/2914	105/9376	1.25638461287054	ITGB5/ACTG1/ITGB8/SGCB/DTNA/SGCE/ITGAV/ADCY1/PRKACB/CACNB3/TPM2/TPM4/CACNA2D1/ATP2A2/CACNB2/ADCY3/SNTB2/ITGB3/PRKACA/ITGA3/EMD/ITGA1/ADCY7/TGFB2/SLC8A1/SNTA1/ITGA2/IGF1/SSPN/ITGB1/PLN/ITGA4/CACNA2D4/ADCY9/CACNB1/AGT/LMNA/CACNA1C/TGFB3/SNTB1/ADCY6	1.77406795446151
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	21/2914	49/9376	1.37895872144328	GALNT15/LFNG/RFNG/B4GALT3/GALNT7/EOGT/PLOD3/C1GALT1C1/B4GALT2/GALNT11/POGLUT1/ST6GAL2/POFUT2/FUT11/POMT2/OGT/GALNT10/MFNG/ST3GAL3/FUT10/GXYLT2	1.78593600628974
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	38/2914	97/9376	1.26049147733303	GNG4/CALM2/ADCY1/PRKACB/GNAI2/GNG11/GNB5/PRKCA/ADCY3/GNB2/MAPK1/CREB1/PRKACA/GNB1/GNG2/ADCY7/PER1/GRIA3/GNAO1/GNB4/GRIA4/GNAQ/CACNA1G/CAMK2D/PER2/NOS1AP/PLCB2/ADCY9/KCNJ5/CACNA1C/RASD1/PER3/GNGT2/CACNA1H/PRKG1/ADCY6/GNB3/GUCY1A2	1.73171226793966
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	26/2914	63/9376	1.32788617620464	ALDH9A1/SETDB2/KMT2E/SETD7/KMT2A/PHYKPL/ASH1L/ACAT1/PLOD3/NSD1/KMT2B/DLST/EZH1/SETD2/AASS/ALDH3A2/HADHA/PRDM2/PRDM6/EHMT2/TMLHE/SETD1B/SETMAR/CAMKMT/SETD1A/KMT2D	1.7534585957079
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	35/2914	89/9376	1.26533665450788	GLUL/GNG4/GABARAPL1/ADCY1/GABARAP/PRKACB/GNAI2/GNG11/GNB5/GABARAPL2/PRKCA/SRC/ADCY3/GABRA2/GNB2/SLC38A2/TRAK2/PRKACA/GNB1/GNG2/PLCL1/ADCY7/ABAT/GNAO1/GNB4/GABBR1/ADCY9/GABRE/CACNA1C/SLC6A12/GNGT2/GPHN/ADCY6/GNB3/CACNA1A	1.68889039060227
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	62/2914	168/9376	1.18743667679838	GLUL/IFNGR2/CAPN2/FTH1/CFLAR/STAT1/IFNAR1/TNFRSF1A/STAT3/FADD/IFNGR1/TRADD/FAS/BCL2/JAK1/SMPD1/STAT2/BIRC2/CHMP3/CYLD/SHARPIN/CASP1/GLUD1/EIF2AK2/XIAP/CHMP4A/VPS4B/STAT5B/PPID/CHMP1B/MAPK10/VPS4A/CHMP4B/FTL/MAPK8/CHMP1A/BID/PYCARD/CHMP6/CHMP7/STAT6/JAK2/TLR4/BIRC3/TRPM7/MLKL/SQSTM1/SPATA2L/CHMP5/CAMK2D/RIPK1/IRF9/TRAF5/CYBB/PYGB/TICAM1/STAT5A/JAK3/TYK2/STAT4/USP21/PYGM	1.6461655029134
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	20/2914	47/9376	1.36917887235503	IRS2/IRS1/SOCS2/PIK3R1/INSR/SOCS1/PIK3CA/MAPK1/IKBKB/SOCS4/MAPK10/MAPK8/CACNA1G/SOCS3/PIK3CD/MTOR/CACNA1C/HK3/CACNA1A/PIK3R2	1.70378643591103
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	31/2914	78/9376	1.27877795962902	ACTG1/PIK3R1/CLTB/VCL/ILK/CAV2/BCAR1/RHOG/SRC/SHC2/WASL/WASF2/PIK3CA/PTK2/CTTN/CRK/CLTC/WASF1/SHC1/DNM1/ITGB1/PIK3CD/DOCK1/RHOA/ELMO2/CAV1/ARHGEF26/CLTCL1/ARPC2/SHC3/PIK3R2	1.66019040930032
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	21/2914	50/9376	1.35137954701441	IL15/HLA-DPB1/HLA-DQA2/HLA-DRA/IL15RA/CXCL12/HLA-DPA1/HLA-DMB/HLA-DMA/HLA-DQA1/TNFSF13B/LTBR/HLA-DRB1/CD86/HLA-DQB1/CXCR4/CD40/HLA-DOA/ITGA4/IL10/HLA-DRB5	1.67286428910512
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	11/2914	23/9376	1.53883799349467	ACE/ATP6AP2/CTSA/ANPEP/ENPEP/PRCP/AGTR1/PREP/NLN/AGT/REN	1.73737511296534
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	50/2914	134/9376	1.20058595150534	RAMP1/MYL9/RAMP3/CALD1/MYL6/ROCK2/NPR1/CALM2/ADCY1/PRKACB/EDNRA/PTGIR/MYLK/PRKCA/ADCY3/GNA13/ARHGEF12/MAPK1/RAF1/ITPR2/MYH11/PRKACA/MYL6B/MAP2K1/ARAF/MAP2K2/PPP1R14A/KCNMB1/GNA11/PPP1R12A/ADCY7/ARHGEF1/MYH9/ROCK1/AGTR1/GNAQ/PPP1R12B/NPR2/ACTA2/ARHGEF11/RHOA/AVPR1A/ADORA2B/PLCB2/ADCY9/AGT/CACNA1C/PRKG1/ADCY6/GUCY1A2	1.57042378797443
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	23/2914	56/9376	1.32150210804981	C3/SAR1B/MYD88/EEF1A1/RELA/ARF1/CASP1/ITGB2/CLK4/IL18/NFKB2/NFKB1/PYCARD/NAIP/HSF1/TLR4/CD14/CR1/TLR5/ITGAM/TLR2/HSPA1A/HSPA6	1.62037978787245
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	9/2914	18/9376	1.60878517501716	HEXA/FUCA2/GLB1/AGA/MAN2C1/MANBA/ENGASE/MAN2B1/GBA2	1.73602404153723
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	15/2914	34/9376	1.41951633089749	CRCP/POLR3GL/POLR3D/POLR1E/POLR2C/POLR2B/POLR3H/POLR2M/POLR3E/POLR2J3/POLR3C/POLR3F/POLR1A/POLR1B/POLR2L	1.64556610695652
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	26/2914	65/9376	1.28702814001373	TRPC4/PIK3R1/AKT3/SPP1/PRKCA/PIK3CA/AKT2/MAPK1/RAF1/ITPR2/MAP2K1/MAP2K2/KRAS/GNA11/GNAQ/CACNA1G/ARRB2/GABBR1/PIK3CD/PLCB2/ARRB1/TRPC1/KCNJ5/CACNA1C/CACNA1H/PIK3R2	1.55930089004688
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	36/2914	94/9376	1.23226098511953	MAPK14/MAPK7/FADD/TRADD/IL17RC/RELA/JUN/IKBKG/TRAF3IP2/USP25/MAPK1/IKBKB/MAPK6/MAPK10/NFKB1/MAPK8/HSP90B1/MAP3K7/TRAF3/JUND/MMP1/MMP9/CXCL10/TAB2/TRAF6/TRAF5/CHUK/IL17RE/FOSL1/CEBPB/MMP3/IKBKE/TAB3/MAPK12/MAPK11/CCL7	1.51972967419454
NA	NA	hsa04081	Hormone signaling	78/2914	219/9376	1.14598396028619	PRLR/GNG4/IRS2/RAMP1/RAMP3/IRS1/ADRA2C/VIPR2/ESR1/NPR1/PRL/PIK3R1/IGF1R/NPR3/STAT3/ITGAV/HEPH/ADCY1/INSR/PRKACB/GNAI2/GNG11/SMAD5/GNB5/HAMP/SMAD9/ACVR1/SRC/ADCY3/THRA/GNA13/OXT/ITGB3/GNB2/PIK3CA/STAT5B/PTHLH/PRKACA/SMAD1/STK11/GNB1/SMAD4/GNG2/BMPR1A/GNA11/APPL1/SLC40A1/JAK2/ADCY7/GNAO1/GNB4/AGTR1/GNAQ/CSH1/GNA15/OXTR/IGF1/NPR2/EPOR/PIK3CD/LEPR/RHOA/AVPR1A/PLCB2/STAT5A/CSH2/THPO/ADCY9/AGT/POMC/ADRB3/GNGT2/PRKG1/SLC16A10/ADCY6/GNA14/GNB3/PIK3R2	1.46790356937283
Organismal Systems	Endocrine system	hsa04924	Renin secretion	27/2914	69/9376	1.25904926740473	CTSB/NPR1/ACE/CALM2/PRKACB/GNAI2/EDNRA/PPP3CC/PPP3CB/ADORA1/ITPR2/CREB1/PRKACA/PTGER4/AGTR1/GNAQ/PLCB2/AGT/PTGER2/CACNA1C/ADRB3/PDE3A/PDE3B/ADCY6/REN/KCNJ2/GUCY1A2	1.45027042940065
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	29/2914	75/9376	1.24412720201327	MAP3K5/GSTT1/PIK3R1/AKT3/GSTM3/FADD/ERCC1/FAS/BCL2/MGST1/BCL2L1/BIRC2/REV3L/XIAP/XPA/PDPK1/PIK3CA/AKT2/MAPK1/BID/TOP2B/BAD/ATM/BIRC3/GSTO1/PIK3CD/CDKN1A/ATP7A/PIK3R2	1.42537428083272
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	37/2914	99/9376	1.20252629243707	HTR2B/IL1R1/PIK3R1/MAPK14/CALM2/ADCY1/PRKACB/BDKRB2/NTRK1/PRKCA/SRC/ADCY3/HRH1/BDKRB1/PIK3CA/ITPR2/MAPK10/PRKACA/MAPK8/PTGER4/ADCY7/GNAQ/CAMK2D/IGF1/MAP2K3/PIK3CD/PLCG1/PLCB2/ADCY9/PTGER2/TRPV2/PLCG2/ASIC3/MAPK12/MAPK11/ADCY6/PIK3R2	1.36032339262667
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	13/2914	30/9376	1.39428048501487	PIGT/B3GALT4/GPAA1/PIGC/DPM2/PIGH/PIGX/PIGV/PIGO/PIGM/PIGQ/PIGL/PIGZ	1.4524458706969
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	13/2914	30/9376	1.39428048501487	ABCC3/MTR/RELA/FPGS/IKBKG/ABCC5/IKBKB/NFKB1/ABCC1/CHUK/ABCC4/FOLR2/MTHFR	1.4524458706969
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	162/2914	480/9376	1.08592999313658	MAP3K5/WNT4/TUBA1A/DAXX/CAPN2/UCHL1/WNT5A/TNFRSF1B/MAPK14/UBE2L6/COX6C/TNFRSF1A/CALM2/GPX1/SNCAIP/MAP1LC3A/PRNP/WNT5B/FADD/RB1CC1/WDR41/DCTN2/OPTN/KIF5B/ERN1/DKK1/FAS/BCL2/COX7A1/CAT/DERL1/DNALI1/WIPI1/ACTR1A/KLC1/PINK1/ACTR10/ATXN1/TUBA3E/BCL2L1/IFT57/DCTN6/GPX7/TANK/RELA/WNT9A/ATP2A2/PRKCA/PPP3CC/BECN1/PPP3CB/ULK1/PSMD3/PSMC2/CSNK1E/ULK2/SDHD/PSMD9/ATXN2/WNT2/HTRA2/RAB5A/APC/CSNK2A1/DNAL4/NDUFS1/MAPK1/RAF1/PPID/ITPR2/CSF1/UBE2G2/MAPK10/TUBB2A/WNT6/ACTR1B/FZD2/CDK5/NFKB1/MAP2K1/MAPK8/NDUFS2/WIPI2/UBE2J1/NRBF2/ARAF/PSMC6/DCTN1/MAP2K2/MFN1/KRAS/BID/COX7A2L/PSMC5/ATF6/ATG13/ATXN3/SPG11/UBE2G1/GPX8/BAD/DVL2/DNAL1/FIG4/KIF5A/CSNK1A1/GRIA3/PSEN1/GRIA4/SQSTM1/MAP2K7/GNAQ/PSEN2/CAMK2D/ZFYVE1/ATG14/MAP2K3/MAP1LC3B/PIK3C3/ATXN1L/NOX4/LRRK2/APP/EIF2AK3/DCTN3/C9orf72/CYBB/FZD3/WNT3/LRP6/TOMM40L/MAP3K10/ATG2B/KLC2/PLCG1/PIK3R4/PLCB2/UQCRB/XBP1/MCU/FZD10/MTOR/HIP1/CACNA1C/ATG2A/TUBB2B/STX1A/TUBA3D/FZD4/AMBRA1/KIF5C/FZD1/MAPK12/DLG4/MAPK11/UBA7/TUBA4A/FZD8/NEFM/HSPA5/FRAT1/NDUFA4L2	1.2978214379854
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	132/2914	388/9376	1.09463733557869	IRS2/MAP3K5/WNT4/TUBA1A/IRS1/CAPN2/RTN3/APOE/SLC39A6/BACE1/WNT5A/PIK3R1/AKT3/COX6C/TNFRSF1A/CALM2/INSR/WNT5B/FADD/RB1CC1/SLC39A13/RTN4/KIF5B/ERN1/DKK1/FAS/PSENEN/COX7A1/LPL/APH1A/WIPI1/KLC1/TUBA3E/ADAM10/RELA/SLC39A14/WNT9A/ATP2A2/PPP3CC/BECN1/PPP3CB/ULK1/PSMD3/PSMC2/CSNK1E/APH1B/ULK2/SDHD/PSMD9/IKBKG/EIF2AK2/WNT2/PIK3CA/APC/CSNK2A1/NDUFS1/SLC39A7/AKT2/MAPK1/RAF1/LRP1/SLC39A3/IKBKB/PPID/ITPR2/CSF1/MAPK10/TUBB2A/WNT6/FZD2/CDK5/NFKB1/MAP2K1/MAPK8/NDUFS2/WIPI2/NRBF2/ARAF/PSMC6/MAP2K2/KRAS/BID/IDE/COX7A2L/PSMC5/ATF6/ATG13/APBB1/BAD/DVL2/KIF5A/CSNK1A1/PSEN1/MAP2K7/GNAQ/BACE2/PSEN2/SLC39A11/ATG14/PIK3C3/NOX4/APP/PIK3CD/EIF2AK3/CHUK/CYBB/FZD3/WNT3/LRP6/ATG2B/KLC2/SLC39A9/PIK3R4/PLCB2/UQCRB/XBP1/MCU/FZD10/MTOR/CACNA1C/ATG2A/TUBB2B/TUBA3D/FZD4/AMBRA1/KIF5C/FZD1/TUBA4A/FZD8/PIK3R2/FRAT1/NDUFA4L2	1.2784795059118
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	21/2914	53/9376	1.27488636510794	ESR1/CLTB/ATP2B4/PRKACB/BDKRB2/AP2M1/PRKCA/CLTC/PRKACA/SLC8A1/VDR/DNM1/GNAQ/ATP1B3/ATP2B1/PLCB2/ADCY9/AP2S1/CLTCL1/KL/ADCY6	1.34759759208248
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	38/2914	104/9376	1.17565070482023	LPGAT1/PLD1/CHPT1/PCYT1A/PISD/CDIPT/PLD3/GPCPD1/PGS1/AGPAT1/AGPAT3/PLA2G15/ETNK1/DGKH/LPIN1/MBOAT7/LPIN2/LPCAT2/AGPAT2/GDPD5/DGKE/SAMD8/SGMS1/CRLS1/MBOAT2/SGMS2/CHKB/GNPAT/AGPAT4/LPIN3/CEPT1/DGKA/PNPLA7/PLD4/ETNK2/DGKD/GPAT2/LCAT	1.20955825571173
NA	NA	hsa04519	Cadherin signaling	136/2914	404/9376	1.08314249407096	WNT4/VIM/ACTG1/PDGFRA/GJA1/MRAS/PDGFRB/CDH11/RRAS/ROCK2/WNT5A/MAPK14/IGF1R/TJP1/WTIP/LHFPL2/PCDH20/WNT5B/CDH13/VCL/PSENEN/APH1A/EGFR/SHOC2/ADAM10/CREBBP/RELA/DAAM1/MYO1E/WNT9A/LATS2/TAOK1/PRICKLE2/ABI2/RRAS2/DCHS1/CDH2/APH1B/KDR/GABRA2/IKBKG/WNT2/MOB1A/ATN1/MYO1C/APC/YAP1/CIB2/PTK2/MAPK1/RAF1/IKBKB/BRK1/YWHAQ/MAPK10/WNT6/NF2/FZD2/PCDHB4/WASF1/NFKB1/MAP2K1/MAPK8/NCKAP1L/MAP2K2/ARHGAP35/TCF7L2/KRAS/PCDH18/PCDHB2/KRT34/RYK/SAV1/EVL/PRICKLE1/CDH3/PCDHB15/DVL2/SCN1B/CSNK1A1/TEAD2/ROCK1/PSEN1/PCDHB16/PCDHGA5/FAT4/MOB1B/PSEN2/TMC1/CDH26/VAV1/KRT10/RERE/PCDHB14/MAP2K3/RAC2/TAOK2/WWTR1/MYO1F/AJUBA/CHUK/RHOA/PCDHGB6/FZD3/WNT3/LRP6/PCDHGC3/PCDHGA12/ENAH/GABRE/PCDHB10/PCDHGB7/FZD10/TMC8/LATS1/PCDHGA3/PCDHB5/ARPC2/FZD4/PCDHB7/PCDHB13/FZD1/PCDHB3/MAPK12/LIMA1/PCDHB12/MAPK11/PCDH19/FZD8/KRT86/CELSR1/VANGL2/PCDHGA9/MYO1D/ANKRD6/KRT81	1.14713896914061
Organismal Systems	Nervous system	hsa04730	Long-term depression	23/2914	60/9376	1.23340196751315	IGF1R/LYN/GNAI2/PRKCA/GNA13/MAPK1/RAF1/PPP2CA/ITPR2/MAP2K1/PPP2CB/ARAF/MAP2K2/KRAS/GNA11/GRIA3/GNAO1/GNAQ/IGF1/PLCB2/PRKG1/CACNA1A/GUCY1A2	1.21790197023274
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	87/2914	254/9376	1.10208118288577	SPHK1/HTR2B/F2R/VEGFA/PDGFRA/PDGFRB/PDGFD/MCOLN1/CALM2/CAMK1/TBXA2R/ADCY1/ATP2B4/PRKACB/FGF2/ORAI2/BDKRB2/PLCD3/EDNRA/FGF7/NTRK1/MYLK/EGFR/EDNRB/STIM1/ORAI3/ATP2A2/PRKCA/PPP3CC/PPP3CB/VEGFB/ADCY3/PLCD1/KDR/PDGFC/HRH1/BDKRB1/ITPKC/NFATC4/CD38/ITPR2/CAMK1D/PRKACA/CXCR4/GNA11/VEGFC/ASPH/ADCY7/SLC8A1/PTAFR/AGTR1/TNNC2/GNAQ/GNA15/CACNA1G/OXTR/CAMK2D/PLN/TPCN1/SPHK2/NTRK2/PDGFA/AVPR1A/ADORA2B/FGF10/ATP2B1/STIM2/PLCG1/ITPKB/PLCB2/PLCE1/NFATC3/ADCY9/TPCN2/MCU/P2RX7/CACNA1C/ADRB3/PLCG2/CACNA1H/ITPKA/MCOLN3/NFATC2/GNA14/CACNA1A/GNAL/NFATC1	1.10755283556554
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	5/2914	10/9376	1.60878517501716	TST/PAPSS2/MPST/ETHE1/PAPSS1	1.2934031860542
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	15/2914	38/9376	1.27009355922407	GFPT2/HEXA/UGDH/GNPDA2/GNPDA1/UXS1/NAGK/PMM1/GMPPA/MPI/AMDHD2/RENBP/FPGT/HK3/UAP1L1	1.1202785652342
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	41/2914	116/9376	1.13724469268454	GLUL/GNG4/HOMER3/ADCY1/PLD1/PRKACB/GNAI2/GNG11/GNB5/PRKCA/PPP3CC/PPP3CB/ADCY3/GNB2/SLC38A2/MAPK1/ITPR2/PRKACA/GNB1/GNG2/DLGAP1/ADCY7/GRIA3/GNAO1/GNB4/GRIA4/GNAQ/NCDN/HOMER2/GRIK2/PLCB2/SLC1A1/ADCY9/TRPC1/CACNA1C/GNGT2/LZTS3/DLG4/ADCY6/GNB3/CACNA1A	0.998771164669724
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	39/2914	110/9376	1.14077494228489	PIK3R1/AKT3/MAPK14/IGF1R/PGR/ADCY1/PRKACB/GNAI2/RPS6KA3/CDC25B/ANAPC13/ADCY3/CDC27/ANAPC7/PIK3CA/AKT2/MAPK1/RAF1/MAPK10/PRKACA/MAP2K1/MAPK8/MAD1L1/ARAF/KRAS/CDC26/ADCY7/FZR1/IGF1/PIK3CD/RPS6KA2/ADCY9/CPEB2/MAPK12/ANAPC2/MAPK11/PDE3B/ADCY6/PIK3R2	0.997292350004458
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	32/2914	89/9376	1.15687922697863	ITGB5/CD44/ITGB8/TNXB/THBS1/LAMA4/ITGAV/COL4A4/LAMB2/SPP1/VTN/THBS3/LAMC1/COL6A3/TNC/ITGB3/AGRN/ITGA3/ITGA1/LAMA3/CD36/ITGA2/COL4A3/ITGB1/COL4A6/THBS2/LAMB1/ITGA4/LAMC3/LAMB3/FREM1/COMP	0.998549632807916
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	31/2914	86/9376	1.15982187036121	ITGB5/ACTG1/GJA1/ITGB8/SGCB/DTNA/SGCE/ITGAV/CACNB3/CACNA2D1/ATP2A2/CDH2/CACNB2/SNTB2/ITGB3/ITGA3/TCF7L2/EMD/ITGA1/SLC8A1/SNTA1/ITGA2/SSPN/ITGB1/ITGA4/CACNA2D4/ACTN2/CACNB1/LMNA/CACNA1C/SNTB1	0.999826198751693
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	30/2914	83/9376	1.16297723495216	CAT/ACAA1/PEX2/HMGCL/SOD2/PEX16/ACSL3/DHRS4/SCP2/ABCD4/MPV17/ACSL1/PHYH/PEX19/PEX10/PEX11B/ABCD3/MLYCD/PEX3/PEX26/GNPAT/PEX1/PEX11G/NUDT12/PAOX/PEX6/ACSL5/PEX12/ACOX2/EPHX2	1.00146311423372
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	30/2914	83/9376	1.16297723495216	IFI16/POLR3GL/FADD/SAMHD1/DNASE2/POLR3D/RELA/CASP1/IKBKG/IL18/IKBKB/ADAR/NFKB1/POLR3H/PCBP1/PYCARD/CXCL10/TREX1/MLKL/IRF7/POLR3E/MAVS/POLR3C/ZDHHC1/RIPK1/POLR3F/CHUK/IKBKE/POLR2L/CCL5	1.00146311423372
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	50/2914	144/9376	1.11721192709525	MAP3K5/PIK3R1/AKT3/RB1CC1/ERN1/WIPI1/ATXN1/RBPJ/ATP2A2/PRKCA/BECN1/ULK1/PSMD3/PSMC2/ULK2/PSMD9/ATXN2/PIK3CA/AKT2/ITPR2/MAPK10/ATXN10/RORA/MAPK8/WIPI2/NRBF2/PSMC6/PSMC5/ATG13/ATXN3/KAT5/GRIA3/GNAQ/ATG14/PIK3C3/ATXN1L/PIK3CD/SP1/ATG2B/PIK3R4/PLCB2/XBP1/TBP/MCU/CIC/MTOR/ATG2A/AMBRA1/CACNA1A/PIK3R2	0.951814002338341
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	41/2914	117/9376	1.12752465257613	ACTG1/BAZ2B/MEAF6/CHD3/SMARCE1/CDK2AP1/PBRM1/EPC1/SMARCA1/SMARCC2/RSF1/DPF2/CDK2AP2/SMARCD1/EPC2/INO80B/PHF6/CHD4/BCL7C/BCL7B/ACTR8/GATAD2B/SS18/TFPT/VPS72/BAZ1B/BRD8/INO80/BPTF/KAT5/MRGBP/INO80D/SMARCD3/SRCAP/PHF10/EP400/MTA1/BCL7A/MORF4L2/TRRAP/YY2	0.932077389540419
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	17/2914	45/9376	1.21552657667963	ABCA8/ABCA6/ABCC3/ABCB8/ABCA9/ABCA1/TAP1/ABCC5/ABCD4/ABCB7/ABCD3/ABCC1/ABCC9/ABCG1/ABCC4/ABCA3/ABCC10	0.973172724080355
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	53/2914	154/9376	1.10734563994688	AKT3/MAPK14/CALM2/ADCY1/ATP2B4/PRKACB/GNAI2/CACNB3/TPM2/CREB3/CREB3L2/BCL2/PPP2R3C/TPM4/CREB3L1/CACNA2D1/ATP2A2/PRKCA/PPP2R5E/CACNB2/ADCY3/PPP2R5B/AKT2/MAPK1/ATF2/PPP2CA/ATF6B/CREB5/CREB1/PRKACA/PPP2CB/PPP2R2D/ADCY7/SLC8A1/SCN1B/AGTR1/GNAQ/CAMK2D/PPP2R3A/PLN/ATP1B3/PIK3R5/ATP2B1/CACNA2D4/PLCB2/ADCY9/CACNB1/AGT/CACNA1C/MAPK12/MAPK11/PIK3CG/ADCY6	0.901943111354489
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	20/2914	54/9376	1.19169272223493	HLA-B/HLA-E/HLA-A/HLA-C/HLA-DPB1/HLA-DQA2/HLA-DRA/HLA-F/HLA-DPA1/HLA-DMB/FAS/HLA-DMA/HLA-DQA1/HLA-DRB1/CD86/HLA-DQB1/CD40/HLA-DOA/IL10/HLA-DRB5	0.948625709269748
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	27/2914	75/9376	1.15832532601235	GPX1/ADCY1/PRKACB/CREB3/CREB3L2/CREB3L1/GPX7/PRKCA/ADCY3/ATF2/ATF6B/ITPR2/CREB5/CREB1/PRKACA/HSP90B1/GPX8/ADCY7/GNAQ/TTF1/ATP1B3/PLCB2/ADCY9/ASGR1/PAX8/ADCY6/HSPA5	0.92440680858743
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	58/2914	170/9376	1.09775929589406	MAP3K5/TUBA1A/MYL9/ACTG1/MYL6/ROCK2/MSN/JAM2/YBX3/TJP1/RAB13/PRKACB/MAGI1/RAP1A/ARHGEF2/TUBA3E/SRC/PRKAG1/JUN/PRKAG2/CDK4/PRKAA1/CTTN/PPP2CA/MAPK10/NF2/MYH11/CD1D/PRKACA/MYL6B/MAPK8/STK11/PPP2CB/WHAMM/CLDN10/PPP2R2D/PRKCI/MYH9/ROCK1/MAP2K7/RUNX1/CLDN23/PARD6G/ITGB1/WAS/RHOA/PRKAB1/MYL12B/DLG3/ARHGEF18/TUBA3D/ARPC2/CLDN12/TUBA4A/PARD6A/MICALL2/CLDN15/PRKAA2	0.863761764237361
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	76/2914	226/9376	1.08201480797614	FXYD1/RAP1B/F2R/MYL9/VIPR2/RRAS/ROCK2/NPR1/PIK3R1/AKT3/CALM2/ADCY1/ATP2B4/PLD1/PRKACB/GNAI2/EDNRA/CREB3/CREB3L2/RAP1A/CREB3L1/PDE4B/CREBBP/RELA/ATP2A2/RRAS2/JUN/ADCY3/OXT/PIK3CA/ADORA1/AKT2/MAPK1/RAF1/CREB5/MAPK10/CREB1/PRKACA/NFKB1/MAP2K1/MAPK8/MAP2K2/PPP1R12A/BAD/ADCY7/PPARA/GRIA3/ROCK1/GRIA4/OXTR/CAMK2D/PDE4A/VAV1/GABBR1/RAC2/PIK3CD/PLN/ATP1B3/ABCC4/PDE10A/RHOA/PTCH1/ATP2B1/PLCE1/ADCY9/POMC/PTGER2/CACNA1C/ARAP3/LIPE/SUCNR1/PDE3A/PDE3B/ADCY6/PIK3R2/NFATC1	0.838074988985739
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	11/2914	28/9376	1.26404549465634	ATP6V1D/ATP6V0A1/ATP6V0D1/ATP6V0E1/ATP6V1C1/TCIRG1/ATP6V1G1/ATP6V1B2/ATP6V1E2/ATP6V1G2/SLC12A7	0.939605089471201
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	12/2914	31/9376	1.24551110323909	SMOX/ALDH9A1/ALDH3B1/DPYD/HIBCH/ALDH3A2/ABAT/ALDH6A1/MLYCD/HADHA/CSAD/AOC3	0.919410093031181
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	28/2914	79/9376	1.14040468102482	CLTB/ATP6V1D/NAPA/ATP6V0A1/ATP6V0D1/AP2M1/VAMP2/STX2/STXBP1/ATP6V0E1/ATP6V1H/CLTC/ATP6V1C1/TCIRG1/ATP6V1G1/ATP6V0B/DNM1/ATP6V1B2/SLC1A1/SYT1/AP2S1/CLTCL1/STX1A/STX3/SLC6A12/ATP6V1E2/ATP6V1G2/CACNA1A	0.841532033693941
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	44/2914	128/9376	1.1060398078243	PAPSS2/ENPP1/NPR1/ADCY1/NTPCR/AK3/PDE8B/NT5E/PDE4B/NUDT9/ADCY3/NME7/PDE8A/GMPR2/NT5C/ENTPD4/PAPSS1/ENTPD3/NUDT16/NT5C2/ADCY7/PDE6D/GUK1/AMPD3/AK9/PDE4A/AK1/NPR2/RRM2B/PRPS1/GMPR/AMPD2/PDE10A/LACC1/PDE6B/PDE7A/ADCY9/PDE3A/PDE3B/ENPP4/ADCY6/PDE9A/PDE5A/GUCY1A2	0.811142097309618
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	16/2914	43/9376	1.19723547908254	ALDH9A1/ACAT1/ACAA1/ACAA2/ACSL3/HADHB/ACSL1/ADH1B/ACADM/CPT1C/CYP2U1/ALDH3A2/HADHA/ADH5/CPT1A/ACSL5	0.870473529940645
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	18/2914	49/9376	1.18196461837995	MAOB/GPSM1/PRKACB/MAOA/GNAI2/CREB3/CREB3L2/CREB3L1/RELA/JUN/ATF2/ATF6B/CREB5/CREB1/CDK5/PRKACA/NFKB1/DLG4	0.857552935047497
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	7/2914	17/9376	1.32488190883766	PCDH20/LAMP1/LAMP2/MYH11/CLEC4M/MYH9/NRP2	0.900289531657457
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	8/2914	20/9376	1.28702814001373	UGDH/CYB5R3/GMPPA/CYB5R4/NANP/NPL/CYB5R2/UAP1L1	0.862861920025043
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	23/2914	65/9376	1.13852489308907	ALDH9A1/LPL/PNPLA2/MGLL/AGPAT1/AGPAT3/DGKH/LPIN1/DGAT1/LPIN2/AGPAT2/DGKE/AKR1A1/ALDH3A2/MBOAT2/GK/AGPAT4/LPIN3/DGKA/AGK/DGKD/ABHD16A/GPAT2	0.752546384745064
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	16/2914	44/9376	1.17002558183066	TAF7/TAF12/GTF2A1/CCNH/GTF2F1/GTF2I/TAF10/GTF2E2/TAF6/GTF2H1/TAF8/TAF1/ERCC3/GTF2E1/GTF2H2C/TBP	0.75910207390678
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	14/2914	38/9376	1.1854206552758	TAP1/UNG/IKBKG/PTPRC/CD40/CD4/BTK/CIITA/IL2RG/RFX5/JAK3/RFXAP/CD3E/ZAP70	0.769077153316459
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	5/2914	12/9376	1.3406543125143	CD46/CLEC4M/NCAM2/NCAM1/ASGR1	0.792904252110295
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	36/2914	107/9376	1.08254703365641	FOXO1/AKT3/CALM2/PRKACB/CREB3/CREB3L2/ACACB/CREB3L1/CREBBP/PPP3CC/PPP3CB/PRKAG1/FBP1/PRKAG2/PRKAA1/AKT2/ATF2/ITPR2/CREB5/CREB1/PRKACA/G6PC3/CPT1C/PPARA/PFKM/GNAQ/CAMK2D/SIK2/PYGB/PRKAB1/PLCB2/CRTC2/CPT1A/PDE3B/PYGM/PRKAA2	0.576665346616284
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	23/2914	67/9376	1.10453907538491	RAP1B/CALM2/ADCY1/PRKACB/RPS6KA3/RAP1A/CREBBP/PRKCA/PPP3CC/PPP3CB/MAPK1/RAF1/ITPR2/PRKACA/MAP2K1/ARAF/MAP2K2/KRAS/GNAQ/CAMK2D/RPS6KA2/PLCB2/CACNA1C	0.57664891054187
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	11/2914	31/9376	1.1417185113025	SEC62/SEC63/TMEM208/SPCS2/OXA1L/SEC61A1/SEC61B/SRPRB/SEC61A2/SEC61G/HSPA5	0.530719091486391
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	6/2914	16/9376	1.20658888126287	HEXA/A4GALT/ST3GAL2/GBGT1/ST3GAL1/B3GALT5	0.555361725734489
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	13/2914	38/9376	1.10074775132753	IRS1/PIK3R1/INSR/PRKCA/PDPK1/PIK3CA/MAPK1/SGK1/KRAS/IGF1/PIK3CD/ATP1B3/PIK3R2	0.417875741398715
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	14/2914	42/9376	1.07252345001144	MAOB/AOC1/ALDH9A1/MAOA/CYP1B1/ACAT1/CAT/AOX1/IL4I1/DLST/ALDH3A2/HADHA/HAAO/INMT	0.316312342006143
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	12/2914	36/9376	1.07252345001144	ST6GALNAC2/GALNT15/GCNT1/GALNT7/C1GALT1C1/ST6GALNAC4/GALNT11/ST3GAL2/ST3GAL1/B4GALT5/GALNT10/ST6GALNAC3	0.292754246293298
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	23/2914	71/9376	1.0423115218421	PDGFRA/PDGFRB/PIK3R1/AKT3/NTRK1/EGFR/SCO2/PIK3CA/HIF1A/AKT2/MAPK1/RAF1/MAP2K1/MAP2K2/KRAS/PFKM/SIRT6/PIK3CD/MYC/MTOR/SIRT3/HK3/PIK3R2	0.24031261362547
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	75/2914	238/9376	1.01394023635535	C3/ACE/PIK3R1/STAT1/MAPK14/IFNAR1/C1S/TNFRSF1A/STAT3/C2/C1QB/MX2/C1QA/IL6ST/MYD88/C1R/JAK1/MX1/EGFR/RELA/PRKCA/STAT2/CASP1/JUN/OAS1/IKBKG/EIF2AK2/OAS2/C1QC/MASP1/PIK3CA/IL6R/C3AR1/MAPK1/IKBKB/RPL36AL/ADAR/MAPK10/NFKB1/MAPK8/IRAK1/MAP3K7/SYK/CFD/TRAF3/IRAK4/FCGR2A/NRP1/RPS4Y1/TLR4/MMP1/CXCL10/AGTR1/MAVS/TAB2/IRF9/TRAF6/TLR7/PIK3CD/TLR2/CHUK/CYBB/IFIH1/PLCG1/HBEGF/C5AR1/MMP3/FGG/IKBKE/PLCG2/MAPK12/MAPK11/TYK2/C5/PIK3R2	0.14627832341795
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	19/2914	59/9376	1.03616672289241	ENPP1/DCTD/NT5E/DPYD/NT5C3B/NME7/NT5C/ENTPD4/CDADC1/NT5C3A/ENTPD3/NT5C2/UCK1/ASMTL/TK2/AK9/RRM2B/CMPK2/CTPS2	0.187130273262877
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	27/2914	85/9376	1.02205175824619	ENPP1/DCTD/NTPCR/AK3/NT5E/NT5C3B/NME7/GMPR2/NT5C/ENTPD4/NT5C3A/ENTPD3/NUDT16/NT5C2/UCK1/GUK1/ASMTL/TK2/AMPD3/AK9/AK1/RRM2B/GMPR/AMPD2/CMPK2/LACC1/CTPS2	0.137141340610842
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	22/2914	69/9376	1.02589199566312	MAOB/CALM2/PRKACB/MAOA/CREB3/CREB3L2/CREB3L1/PRKCA/PPP3CC/PPP3CB/JUN/ATF2/ATF6B/CREB5/CREB1/PRKACA/GRIA3/GRIA4/CAMK2D/ARC/CACNA1C/STX1A	0.144954649146792
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	12/2914	37/9376	1.04353632974086	APOA1/LAMA4/VCAM1/APOL1/FAS/MYD88/PRKCA/IL18/GNAQ/ICAM1/IL10/PLCB2	0.178176089539485
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	7/2914	21/9376	1.07252345001144	ENPP1/DPYD/PANK2/PPCS/BCAT1/ALDH3A2/CSAD	0.2234154188122
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	34/2914	108/9376	1.01293881389969	KPNA3/PHAX/NCBP2/EEF1A1/RANBP2/UBE2I/NUP214/THOC2/SEC13/RANGAP1/DDX19B/UPF2/ACIN1/NXT1/SUMO1/DDX39B/KPNA6/KPNA1/UPF3A/THOC5/CASC3/SUMO2/AHCTF1/KPNA5/IPO8/DDX19A/TPR/POM121C/IPO13/GLE1/NUP35/NUP133/XPO7/RANBP17	0.0908155602869004
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	6/2914	18/9376	1.07252345001144	ACACB/ACSL3/MCAT/ACSL1/ACSF3/ACSL5	0.206809327759227
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	10/2914	31/9376	1.03792591936591	H6PD/DERA/FBP1/PGD/IDNK/RBKS/PGLS/PFKM/PRPS1/RGN	0.142028089941601
NA	NA	hsa04981	Folate transport and metabolism	10/2914	31/9376	1.03792591936591	ABCC3/MTR/FPGS/ABCC5/BHMT2/SLCO2B1/ABCC1/ABCC4/FOLR2/MTHFR	0.142028089941601
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	18/2914	57/9376	1.01607484737926	ACAT1/ACAA1/ACAA2/ACSL3/MCAT/PPT1/SCP2/HSD17B12/HADHB/ACSL1/ACADM/ACSF3/CPT1C/ELOVL4/HADHA/CPT1A/SCD5/ACSL5	0.0817422457784736
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	31/2914	100/9376	0.997446808510638	TNFRSF1B/TNFRSF1A/CXCL12/IL6ST/TNFRSF14/ACKR4/LTBR/IL6R/IL18/CSF1/CCL8/CXCR4/CXCL10/IL19/CCL18/CCL26/CXCL9/IL2RA/IL2RG/PPBP/IL10/IL18R1/TNFSF14/TNFRSF10D/PF4/XCL2/CX3CR1/CCL7/XCL1/ACKR3/CCL5	-0.0172365345092196
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	7/2914	22/9376	1.02377238410183	MAOB/AOC1/ALDH9A1/MAOA/HNMT/ALDH3B1/ALDH3A2	0.0749604752723436
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	60/2914	195/9376	0.990021646164405	C3/ACTG1/PIK3R1/AKT3/MAPK14/FCGR3A/HDAC7/ATG7/RELA/SELPLG/PRKCA/SRC/FPR3/CASP1/ITGB3/CLCN3/PIK3CA/ITGB2/AKT2/MAPK1/RAF1/NCF2/NFKB1/MAP2K1/MAP2K2/MAP3K7/HDAC3/SIGLEC9/SYK/FCGR1A/CAMP/FCGR2A/TLR4/CR1/TLR7/HDAC11/RAC2/PIK3CD/ITGAM/TLR2/CYBB/PLCG1/ITGAL/PLCB2/HDAC4/C5AR1/FGG/MTOR/HDAC10/CYBA/AQP9/PLCG2/HDAC6/MAPK12/MAPK11/C5/HDAC9/FPR1/CLCN5/PIK3R2	-0.0945536170884414
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	5/2914	16/9376	1.00549073438572	MAOB/MAOA/ALDH3B1/IL4I1/AOC3	0.0147604445377939
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	35/2914	115/9376	0.979260541314792	GNG4/MAOB/HTR2B/KCND2/PRKACB/MAOA/GNAI2/GNG11/DUSP1/GNB5/PRKCA/GNB2/MAPK1/RAF1/ITPR2/ALOX5/PRKACA/MAP2K1/GNB1/GNG2/ARAF/KRAS/GNAO1/GNB4/GNAQ/PTGS1/APP/PLCB2/TRPC1/KCNJ5/CACNA1C/GNGT2/ALOX15B/GNB3/CACNA1A	-0.15026724701662
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	91/2914	298/9376	0.982546650513835	PRLR/TNFRSF12A/IFNGR2/IL13RA1/IL15/PRL/IL15RA/CLCF1/TNFRSF8/TNFRSF1B/IL1R1/IFNAR1/TNFRSF1A/TNFSF12/IL32/CXCL12/OSMR/INHBB/TNFRSF21/IFNGR1/TGFBR1/IL6ST/FAS/IL4R/RELL1/TNFRSF14/ACKR4/TGFBR2/BMPR2/IL17RC/ACVR1/TNFSF13B/LTBR/CTF1/IL6R/IL1RL1/IL18/IL13RA2/CSF1/BMP4/CCL8/CXCL16/IL11/BMPR1A/TNFRSF11B/CXCR4/IL16/IL1R2/TGFB2/CD40/CXCL10/IL19/INHBA/CSH1/CCL18/CD4/CCL26/CXCL9/GDF7/EPOR/ACVR1B/IL2RA/IL2RG/IL17RE/LEPR/PPBP/IL10/IL27RA/IL12RB1/CSH2/IL18R1/THPO/TNFSF14/ACVR2A/TNFRSF10D/TNFSF15/RELT/OSM/BMP2/PF4/TGFB3/IL1RL2/XCL2/CX3CR1/TNFRSF18/CCL7/XCL1/LIF/ACKR3/RELL2/CCL5	-0.2056074102923
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	48/2914	158/9376	0.977489726592704	CHEK2/GADD45G/ABL1/ATRX/CDC25B/ANAPC13/CDKN2B/CREBBP/RB1/PPP2R5E/CDC27/ESCO1/NIPBL/CCNH/CDK4/ANAPC7/SMAD2/RBL2/PPP2R5B/STAG1/PPP2CA/YWHAQ/PDS5B/MAD1L1/CDKN1B/PPP2CB/SMAD4/MAD2L1BP/CDC26/SMAD3/STAG2/TGFB2/CCND2/ATM/FZR1/CDKN2D/CDKN2C/ATR/MAU2/ZBTB17/CDKN1A/MYC/CDC14B/GADD45A/CDC14A/GADD45B/TGFB3/ANAPC2	-0.19161870314652
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	19/2914	63/9376	0.970378359534159	POLD4/ERCC1/XPC/ERCC4/RFC1/CETN2/CCNH/POLR2C/XPA/POLR2B/GTF2H1/POLR2M/RAD23B/POLR2J3/ERCC5/DDB2/ERCC3/GTF2H2C/POLR2L	-0.158409606330525
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	4/2914	13/9376	0.990021646164405	RAD50/LIG4/POLL/POLM	-0.0241751957678071
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	14/2914	47/9376	0.95842521064852	ALDH9A1/ACAT1/ACACB/PC/ACYP2/HAGH/ME2/GRHPR/ME3/ADH1B/AKR1A1/ALDH3A2/ME1/ADH5	-0.191870574069013
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	11/2914	37/9376	0.956574968929121	GFPT2/UGDH/UXS1/NAGK/PMM1/GMPPA/MPI/NANP/FPGT/HK3/UAP1L1	-0.17772059037577
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	8/2914	27/9376	0.953354177787946	ACAT1/HMGCL/OXCT1/ABAT/HADHA/ACSM5/ALDH5A1/OXCT2	-0.16298926072808
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	16/2914	54/9376	0.953354177787946	ERCC1/POLK/REV3L/ERCC4/WDR48/MUS81/FANCF/REV1/PMS2/ATR/PALB2/HES1/FAN1/SLX4/TOP3B/POLN	-0.230835191156344
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	13/2914	44/9376	0.950645785237412	POLD4/PARP4/MPG/UNG/RFC1/MBD4/OGG1/APTX/PARP3/PNKP/POLL/APEX1/POLG	-0.220348528609271
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	5/2914	17/9376	0.946344220598328	HSD3B7/CYP27A1/SCP2/CYP7B1/ACOX2	-0.148687061957594
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	47/2914	157/9376	0.963221697144031	IRS2/MAP3K5/IRS1/PIK3R1/AKT3/MAPK14/COX6C/TNFRSF1A/INSR/ERN1/FAS/COX7A1/RELA/PRKAG1/JUN/SDHD/PRKAG2/PIK3CA/IL6R/PRKAA1/NDUFS1/AKT2/IKBKB/MLX/MAPK10/NFKB1/MAPK8/NDUFS2/BID/NR1H3/COX7A2L/GSK3A/MLXIP/PPARA/BCL2L11/SOCS3/PIK3CD/EIF2AK3/LEPR/PRKAB1/UQCRB/XBP1/MAPK12/MAPK11/PIK3R2/PRKAA2/NDUFA4L2	-0.312066060531147
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	111/2914	368/9376	0.970517143624481	MAP3K5/TUBA1A/ACTG1/DAXX/TNFRSF1B/ANG/MAPK14/COX6C/TNFRSF1A/GPX1/MAP1LC3A/RB1CC1/WDR41/DCTN2/OPTN/KIF5B/ERN1/BCL2/COX7A1/CAT/DERL1/DNALI1/WIPI1/ACTR1A/ANXA7/KLC1/PINK1/ACTR10/TUBA3E/BCL2L1/DCTN6/GPX7/TANK/SETX/PPP3CC/BECN1/PPP3CB/ULK1/PSMD3/PSMC2/ULK2/CASP1/RANBP2/SDHD/PSMD9/ATXN2/RAB5A/NUP214/PFN2/MATR3/DNAL4/NDUFS1/UBQLN1/SEC13/ANXA11/TUBB2A/ACTR1B/NDUFS2/WIPI2/NRBF2/PSMC6/DCTN1/NXT1/BID/COX7A2L/PSMC5/ATF6/ATG13/SPG11/GPX8/BAD/DNAL1/FIG4/UBQLN2/KIF5A/SQSTM1/ATG14/MAP2K3/MAP1LC3B/PIK3C3/TPR/EIF2AK3/POM121C/DCTN3/UBQLN4/C9orf72/GLE1/NUP35/HNRNPA1L2/TOMM40L/ATG2B/KLC2/PIK3R4/UQCRB/XBP1/MCU/MTOR/ATG2A/NUP133/TUBB2B/TUBA3D/AMBRA1/HDAC6/KIF5C/MAPK12/MAPK11/TUBA4A/NEFM/HSPA5/PFN4/NDUFA4L2	-0.38745940968431
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	15/2914	52/9376	0.92814529327913	IGF1R/ADCY1/INSR/PRKACB/CYP1B1/ADCY3/ALOX5/PRKACA/SCARB1/ADCY7/STAR/IGF1/ADCY9/ACOT2/ADCY6	-0.348901386741283
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	10/2914	35/9376	0.919305814295519	HSD17B14/FBP1/PMM1/GMPPA/MPI/PFKM/PFKFB3/FPGT/HK3/PFKFB2	-0.321163745873158
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	44/2914	149/9376	0.950155002694698	GNG4/MAPK14/ADCY1/PRKACB/GNAI2/CNR1/GNG11/GNB5/PRKCA/ADCY3/MGLL/GABRA2/GNB2/NDUFS1/MAPK1/ITPR2/MAPK10/PRKACA/MAPK8/NDUFS2/GNB1/GNG2/ADCY7/GRIA3/GNAO1/GNB4/GRIA4/DAGLB/GNAQ/PLCB2/ABHD6/ADCY9/GABRE/NAPEPLD/KCNJ5/CACNA1C/DAGLA/GNGT2/MAPK12/MAPK11/ADCY6/GNB3/CACNA1A/NDUFA4L2	-0.411842712713957
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	17/2914	59/9376	0.927096541535312	GSTT1/GGT5/GPX1/GSTM3/ANPEP/MGST1/TXNDC12/GPX7/PGD/LAP3/GPX8/GSTO1/RRM2B/LANCL1/GCLC/GGT7/CHAC2	-0.377209849642476
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	25/2914	86/9376	0.935340218033232	ADCY1/PRKACB/CREB3/CREB3L2/CREB3L1/VAMP2/PRKCA/ADCY3/ATF2/ATF6B/CREB5/CREB1/PRKACA/KCNMB1/GNA11/ADCY7/GNAQ/CAMK2D/ATP1B3/PLCB2/ADCY9/RIMS2/CACNA1C/STX1A/ADCY6	-0.40450373825458
Organismal Systems	Digestive system	hsa04970	Salivary secretion	27/2914	93/9376	0.934133327429318	CST3/CALM2/ADCY1/ATP2B4/SLC4A2/LYZ/PRKACB/BST1/VAMP2/PRKCA/ADCY3/CD38/ITPR2/PRKACA/CAMP/ADCY7/CST2/GNAQ/ATP1B3/ATP2B1/PLCB2/ADCY9/SLC12A2/ADRB3/PRKG1/ADCY6/GUCY1A2	-0.428657037906986
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	5/2914	18/9376	0.893769541676199	MTR/THAP11/ABCD4/TCN2/MMAA	-0.302928910166775
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	9/2914	32/9376	0.904941660947152	ACACB/SUCLA2/HIBCH/ECHDC1/ACSS3/ABAT/ALDH6A1/MLYCD/HADHA	-0.361697686547719
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	14/2914	50/9376	0.900919698009609	MAOB/P4HA3/AOC1/SAT1/SMOX/ALDH9A1/MAOA/PYCR2/SAT2/OAT/L3HYPDH/LAP3/ALDH3A2/CKM	-0.471706166058316
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	22/2914	78/9376	0.907519842317371	TOB1/LSM1/DDX6/XRN1/CNOT4/XRN2/CNOT2/C1D/DCP1B/EXOSC4/EXOSC7/NUDT16/ZCCHC7/CNOT8/PFKM/DHX36/CNOT6L/PABPC5/CNOT10/DIS3L/ENO2/EDC3	-0.550741784033406
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	19/2914	68/9376	0.899027009568412	DHRS3/ALDH1A1/RDH10/RDH11/ALDH1A2/AOX1/DHRS4/DGAT1/PNPLA4/ADH1B/CYP2A6/HSD17B6/CYP2A7/RETSAT/ADH5/CYP27C1/RDH12/RDH5/CYP3A5	-0.561149296389996
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	6/2914	23/9376	0.839366178269822	ACAT1/FNTA/GGPS1/RCE1/PCYOX1/DHDDS	-0.517931563000079
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	66/2914	227/9376	0.935505035692797	NFE2L2/MAP3K5/VEGFA/GSTT1/PIK3R1/AKT3/MAPK14/COX6C/PLD1/ABL1/GSTM3/CYP1B1/COX7A1/CAT/EGFR/MGST1/SOD2/PTPN11/RELA/SRC/JUN/SDHD/IKBKG/PDPK1/KEAP1/PIK3CA/HIF1A/PTPN1/PTK2/NDUFS1/AKT2/MAPK1/RAF1/IKBKB/NCF2/MAPK10/NFKB1/MAP2K1/MAPK8/NDUFS2/ARAF/MAP2K2/KRAS/COX7A2L/AKR1A1/BAD/SOS2/MAP2K7/ABL2/GSTO1/NOX4/AHR/PIK3CD/PRKD2/MAP2K4/PRKD1/CHUK/FOXO3/UQCRB/PTPRJ/CYBA/MAPK12/MAPK11/PIK3R2/EPHX2/NDUFA4L2	-0.660539596207115
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	29/2914	103/9376	0.905917865543643	PPP2R3C/NCBP2/SMG6/PELO/PPP2R5E/GSPT2/PPP2R5B/PPP2CA/WDR82/PPP2CB/DDX19B/UPF2/ACIN1/NXT1/DDX39B/PPP2R2D/CSTF2T/UPF3A/CASC3/RNMT/CSTF1/CPSF7/CLP1/PPP2R3A/DDX19A/PABPC5/PAPOLG/GLE1/MSI1	-0.644707287452515
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	3/2914	12/9376	0.804392587508579	COQ2/VKORC1L1/VKORC1	-0.455294248189592
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	68/2914	235/9376	0.931041633201419	MAP3K5/ACTG1/NPR1/RHEB/MAPK14/COX6C/ADCY1/PRKACB/RPS6KA3/ZNF516/CNR1/CREB3/SMARCE1/CREB3L2/COX7A1/CREB3L1/PNPLA2/SMARCC2/ACSL3/PRKAG1/ADCY3/MGLL/SDHD/PRKAG2/SMARCD1/SLC25A29/NDUFAF3/PRKAA1/NDUFS1/ATF2/COA5/ACSL1/CREB5/CREB1/NDUFAF7/PRKACA/NDUFS2/KRAS/CPT1C/SLC25A20/COX7A2L/COX11/RPS6KB1/FRS2/ADCY7/SOS2/SMARCD3/SIRT6/MAP2K3/NDUFAF5/PRKAB1/RPS6KA2/ADCY9/UQCRB/CPT1A/MTOR/TSC2/ADRB3/ACSL5/LIPE/MAPK12/KDM3A/PRKG1/MAPK11/ADCY6/COX18/PRKAA2/NDUFA4L2	-0.718904130537897
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	5/2914	20/9376	0.804392587508579	LIPA/SOAT1/SOAT2/LSS/CYP2R1	-0.588033589687081
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	8/2914	31/9376	0.830340735492727	HSD17B14/ALDH9A1/UGDH/GUSB/AKR1A1/ALDH3A2/RGN/KL	-0.635353913147979
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	6/2914	24/9376	0.804392587508579	EXT2/B3GALT6/HS2ST1/NDST2/EXT1/EXTL3	-0.644296267009849
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	7/2914	28/9376	0.804392587508579	ACAA2/PPT1/HSD17B12/HADHB/ELOVL4/HADHA/ACOT2	-0.696068382285572
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	4/2914	17/9376	0.757075376478663	GGT5/ADO/CSAD/GGT7	-0.67317535876512
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	4/2914	17/9376	0.757075376478663	GLUL/GLUD1/CA5B/CA12	-0.67317535876512
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	13/2914	51/9376	0.820164991185218	PLA2G7/PLD1/CHPT1/PAFAH1B1/PLD3/TMEM86A/LPCAT2/PAFAH1B2/ENPP2/CEPT1/PAFAH2/PLD4/TMEM86B	-0.864732622796097
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	88/2914	308/9376	0.919305814295519	MAP3K5/TUBA1A/TGM2/COX6C/CLTB/GPX1/RB1CC1/DCTN2/KIF5B/ERN1/CREB3/CREB3L2/COX7A1/DNALI1/WIPI1/ACTR1A/KLC1/AP2M1/CREB3L1/ACTR10/TUBA3E/SOD2/IFT57/DCTN6/GPX7/CREBBP/BECN1/ULK1/PSMD3/PSMC2/ULK2/SDHD/PSMD9/POLR2C/POLR2B/DNAL4/NDUFS1/CLTC/CREB5/MAPK10/CREB1/TUBB2A/ACTR1B/MAPK8/NDUFS2/WIPI2/NRBF2/PSMC6/DCTN1/COX7A2L/REST/PSMC5/ATG13/GPX8/DNAL1/KIF5A/GRIA3/GRIA4/MAP2K7/GNAQ/POLR2J3/ATG14/PIK3C3/DCTN3/SP1/MAP3K10/ATG2B/KLC2/SIN3A/PIK3R4/PLCB2/UQCRB/TBP/MTOR/HIP1/ATG2A/AP2S1/CLTCL1/TUBB2B/STX1A/TUBA3D/AMBRA1/KIF5C/POLR2L/DLG4/TUBA4A/NRF1/NDUFA4L2	-0.966960605447906
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	9/2914	37/9376	0.782652247305645	MAOB/MAOA/ALDH3B1/AOX1/FAHD1/IL4I1/ADH1B/ADH5/AOC3	-0.88951395020628
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	6/2914	26/9376	0.742516234623304	APOA1/BTD/ABCD4/SCARB1/ABCC1/TCN2	-0.882831163502062
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	37/2914	138/9376	0.862681905443984	MAPK14/IGF1R/CALM2/PGR/ADCY1/PRKACB/RPS6KA3/FBXW11/SLK/ANAPC13/PPP3CC/PPP3CB/PPP2R5E/ADCY3/CDC27/ANAPC7/PPP2R5B/MAPK1/PPP2CA/ITPR2/YWHAQ/PRKACA/MAP2K1/MAD1L1/PPP2CB/CDC26/AR/ADCY7/CAMK2D/IGF1/RPS6KA2/ADCY9/CPEB2/MAPK12/ANAPC2/MAPK11/ADCY6	-1.0912525405291
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	6/2914	27/9376	0.715015633340959	ACAA1/SCP2/HSD17B12/ELOVL4/ACOT2/SCD5	-0.99578888393597
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	19/2914	76/9376	0.804392587508579	ACTG1/CALM2/ADCY1/SLC4A2/PRKACB/GNAI2/MYLK/PRKCA/ADCY3/ITPR2/PRKACA/ADCY7/GNAQ/CAMK2D/ATP1B3/PLCB2/ADCY9/ADCY6/KCNJ2	-1.14973450470832
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	10/2914	43/9376	0.748272174426585	APOA1/ABCA1/ACAT1/AGPAT1/DGAT1/AGPAT2/SCARB1/SLC27A4/CD36/SLC27A1	-1.11096852316047
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	6/2914	28/9376	0.689479360721639	B4GALT3/B4GALT2/A4GALT/ST3GAL3/B3GALT5/FUT4	-1.10498675022477
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	8/2914	36/9376	0.715015633340959	ENPP1/PGM2L1/GANC/GYG1/G6PC3/PYGB/HK3/PYGM	-1.15039181745326
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	11/2914	48/9376	0.737359871882864	PIK3R1/AKT3/PIK3CA/AKT2/G6PC3/PIK3CD/ATP1B3/PLCB2/HK3/SLC2A5/PIK3R2	-1.22499514261877
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	26/2914	103/9376	0.812202224280507	COL12A1/SLC7A8/CPB1/COL4A4/COL7A1/COL18A1/SLC7A7/COL15A1/COL8A1/PRCP/COL6A3/SLC38A2/SLC3A2/SLC36A4/COL5A2/SLC8A1/COL5A3/COL4A3/KCNE3/COL4A6/ATP1B3/COL23A1/SLC1A1/COL24A1/COL17A1/SLC16A10	-1.28690314344318
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	8/2914	37/9376	0.695690886493906	GLUL/GFPT2/ASS1/ASL/GLUD1/IL4I1/ABAT/ALDH5A1	-1.24541063012154
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	9/2914	41/9376	0.706295930495338	MAOB/SDSL/MAOA/SDS/GRHPR/SRR/SARDH/AOC3/DMGDH	-1.26558601273627
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	9/2914	41/9376	0.706295930495338	POLD4/NBN/UIMC1/RAD50/MUS81/ATM/PALB2/TOP3B/RAD51B	-1.26558601273627
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	40/2914	154/9376	0.835732558450472	DHRS3/UGDH/AK3/RDH11/COQ2/MOCS2/VKORC1L1/GUSB/FPGS/PANK2/NME7/PMM1/UROD/GMPPA/PPOX/NADK/MPI/PPCS/AKR1A1/BCAT1/ALDH3A2/PNPO/MTHFD2L/MAT2B/NMNAT1/AK9/LIPT1/HAAO/HSD17B6/AK1/SPR/GCLC/CMPK2/RGN/NMNAT2/PHOSPHO2/VKORC1/GPHN/CTPS2/RDH12	-1.38021336869151
Organismal Systems	Digestive system	hsa04978	Mineral absorption	14/2914	61/9376	0.738458768860335	CYBRD1/FTH1/HEPH/ATP2B4/FTL/SLC40A1/SLC8A1/VDR/TRPM7/ATP1B3/ATP2B1/ATOX1/ATP7A/STEAP2	-1.37613356161751
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	6/2914	30/9376	0.643514070006863	PC/SUCLA2/SDHD/ACO2/DLST/ACO1	-1.3132187279331
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	10/2914	46/9376	0.699471815224851	PSMB8/PSMD3/PSMC2/PSMF1/PSMB9/PSMD9/PSMB10/PSMC6/PSMC5/PSME4	-1.37205094488171
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	25/2914	102/9376	0.78862018383194	RAP1B/CPB1/ADCY1/ATP2B4/SLC4A2/BST1/RAP1A/ATP2A2/PRKCA/ADCY3/CD38/ITPR2/ADCY7/RAB27B/GNAQ/ATP1B3/RHOA/ATP2B1/PLCB2/RAB3D/ADCY9/TPCN2/TRPC1/SLC12A2/ADCY6	-1.44137501958173
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	54/2914	205/9376	0.847555116594406	IRS1/CTSD/ACE/PIK3R1/AKT3/MAPK14/COX6C/GFPT2/INSR/TGFBR1/MMP2/COX7A1/TGFBR2/RELA/ATP2A2/PRKCA/MPC1/SDHD/PIK3CA/SMAD2/NDUFS1/AKT2/PDK4/NCF2/MAPK10/NFKB1/MAPK8/TBC1D4/NDUFS2/COX7A2L/SMAD3/PPARA/TGFB2/CD36/MMP9/AGTR1/PDK2/CAMK2D/RAC2/PIK3CD/PLN/CYBB/SP1/PLCB2/UQCRB/AGT/MTOR/CYBA/MAPK12/TGFB3/MAPK11/REN/PIK3R2/NDUFA4L2	-1.4819323252247
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	8/2914	39/9376	0.66001443077627	MTR/BHMT2/MTHFD2L/MAT2B/MTHFR/ALDH1L2/SARDH/DMGDH	-1.42868354548004
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	6/2914	31/9376	0.622755551619545	GLUL/ACAT1/CAT/ACO2/GRHPR/ACO1	-1.41273591623756
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	4/2914	23/9376	0.559577452179881	GLUL/ASS1/ASL/GLUD1	-1.42005423338625
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	4/2914	23/9376	0.559577452179881	POLD4/MLH3/RFC1/PMS2	-1.42005423338625
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	28/2914	116/9376	0.776654912077249	H6PD/SDSL/ACAT1/CAT/PC/SUCLA2/HIBCH/SDHD/FBP1/GLUD1/SDS/PGD/IDNK/ACO2/DLST/ADPGK/ME2/ME3/PGLS/ACO1/ALDH6A1/PFKM/PRPS1/RGN/ME1/ADH5/ENO2/HK3	-1.62534979841148
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	6/2914	32/9376	0.603294440631434	GANC/GLB1/B4GALT2/G6PC3/PFKM/HK3	-1.50946760162153
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	5/2914	28/9376	0.574566133934699	MOCS2/FPGS/PCBD1/SPR/GPHN	-1.51390511816396
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	2/2914	15/9376	0.429009380004576	NTPCR/AK1	-1.4861423691633
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	11/2914	54/9376	0.655430997229213	TST/SDSL/MTR/MPST/SDS/IL4I1/BHMT2/BCAT1/MAT2B/GCLC/LACC1	-1.70516131668896
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	71/2914	275/9376	0.830718163099769	TUBA1A/FYN/PIK3R1/MAPK14/COX6C/PRNP/PRKACB/C1QB/C1QA/KIF5B/CREB3/CREB3L2/COX7A1/CAV2/KLC1/CREB3L1/TUBA3E/LAMC1/PPP3CC/PPP3CB/PSMD3/PSMC2/SDHD/PSMD9/C1QC/PIK3CA/CSNK2A1/NDUFS1/MAPK1/ATF2/ATF6B/NCF2/ITPR2/CREB5/MAPK10/CREB1/TUBB2A/PRKACA/MAPK8/NDUFS2/PSMC6/COX7A2L/PSMC5/NOTCH1/BAD/KIF5A/RAC2/PIK3CD/EIF2AK3/CYBB/NCAM2/NCAM1/KLC2/UQCRB/HSPA1A/MCU/CAV1/CACNA1C/TUBB2B/TUBA3D/CYBA/HSPA6/KIF5C/MAPK12/MAPK11/C5/TUBA4A/PIK3R2/HSPA5/CCL5/NDUFA4L2	-1.91328244961511
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	6/2914	36/9376	0.536261725005719	UGDH/FGGY/GUSB/CRYL1/AKR1A1/KL	-1.87196484932655
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	67/2914	268/9376	0.804392587508579	NFE2L2/MAP3K5/MAOB/TUBA1A/DAXX/UCHL1/SLC39A6/UBE2L6/COX6C/CALM2/SNCAIP/PRKACB/MAOA/GNAI2/SLC39A13/TXN/KIF5B/ERN1/DUSP1/COX7A1/KLC1/PINK1/TUBA3E/BCL2L1/SLC39A14/PSMD3/PSMC2/SDHD/PSMD9/HTRA2/KEAP1/NDUFS1/SLC39A7/SLC39A3/ITPR2/UBE2G2/MAPK10/TUBB2A/PRKACA/MAPK8/NDUFS2/UBE2J1/PSMC6/MFN1/COX7A2L/PSMC5/ATF6/UBE2G1/KIF5A/SLC39A11/CAMK2D/LRRK2/EIF2AK3/KLC2/PLCG1/SLC39A9/UQCRB/XBP1/MCU/TUBB2B/TUBA3D/KIF5C/UBA7/TUBA4A/HSPA5/GNAL/NDUFA4L2	-2.18166532635572
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	15/2914	75/9376	0.643514070006863	GLUL/SDSL/MTR/PYCR2/PC/ASS1/ASL/SDS/ACO2/BCAT1/ACO1/MAT2B/PFKM/PRPS1/ENO2	-2.0813980248843
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	13/2914	67/9376	0.624304694782778	ALDH9A1/ALDH3B1/MINPP1/FBP1/ADPGK/ADH1B/G6PC3/AKR1A1/ALDH3A2/PFKM/ADH5/ENO2/HK3	-2.07237616796895
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	82/2914	323/9376	0.816844485148031	CD44/IRS2/VEGFA/MARCKS/TIMP3/VIM/PDGFRA/IRS1/PDGFRB/TNXB/PIM1/ZEB1/THBS1/FOXP1/PIK3R1/MAPK7/STAT3/PLAU/ABL1/CYP1B1/BCL2/EGFR/CDC25B/BMPR2/CREBBP/PRKCA/SOCS1/TNC/UBE2I/ITGB3/SOX4/PIK3CA/APC/CRK/MAPK1/BMI1/RAF1/IKBKB/NFKB1/SHC1/RECK/MAP2K1/CDKN1B/EFNA5/MAP2K2/RASSF1/KRAS/SPRY2/DICER1/ZEB2/NOTCH1/SLC45A3/TGFB2/SOS2/CCND2/ATM/MMP9/ABCC1/NOTCH2/HOXD10/ROCK1/MIR29A/DDIT4/BCL2L11/PIK3CD/PDGFA/CDKN1A/RHOA/FZD3/WNT3/MYC/PLCG1/NOTCH3/HDAC4/BCL2L2/ST14/MTOR/NOTCH4/MIR145/PLCG2/BMF/PIK3R2	-2.24942716707144
Organismal Systems	Sensory system	hsa04744	Phototransduction	4/2914	29/9376	0.443802806901285	CALM2/GNB1/PDE6B/RCVRN	-2.01436703448353
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	2/2914	19/9376	0.338691615793086	DLST/LIPT1	-1.93757913743563
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	17/2914	87/9376	0.628720643110154	COX6C/CACNB3/TPM2/COX7A1/TPM4/CACNA2D1/ATP2A2/CACNB2/COX7A2L/ASPH/SLC8A1/ATP1B3/CACNA2D4/UQCRB/CACNB1/CACNA1C/SLC9A6	-2.33626919764453
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	11/2914	63/9376	0.561797997625039	GGT5/PTGIS/ALOX5/LTA4H/TBXAS1/CYP2U1/PTGR2/CBR3/PTGS1/ALOX15B/EPHX2	-2.34340183723158
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	7/2914	46/9376	0.489630270657396	FTH1/HEPH/GUSB/BLVRA/UROD/FTL/PPOX	-2.33007519713155
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	13/2914	73/9376	0.572991980143097	MAOB/GSTT1/GSTM3/MAOA/ALDH3B1/AOX1/MGST1/ADH1B/CYP2A6/GSTO1/CYP2A7/ADH5/CYP3A5	-2.45942105372173
Human Diseases	Substance dependence	hsa05034	Alcoholism	43/2914	191/9376	0.724374476709296	GNG4/MAOB/CALM2/PRKACB/MAOA/GNAI2/GNG11/CREB3/CREB3L2/HDAC7/GNB5/CREB3L1/SHC2/GNB2/MAPK1/ATF2/RAF1/ATF6B/CREB5/CREB1/CAMKK2/PRKACA/SHC1/MAP2K1/GNB1/GNG2/ARAF/KRAS/HDAC3/SOS2/GNAO1/GNB4/HDAC11/NTRK2/ADORA2B/HDAC4/HDAC10/CAMKK1/HDAC6/GNGT2/HDAC9/SHC3/GNB3	-2.58430322605689
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	15/2914	82/9376	0.588579942079448	GSTT1/GSTM3/MGST1/DPYD/GUSB/NME7/CES2/CDADC1/UCK1/TK2/CYP2A6/GSTO1/RRM2B/CYP2A7/NAT1	-2.51268465883584
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	4/2914	33/9376	0.390008527276887	ACO2/DLST/BCAT1/ACO1	-2.3571352059527
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	14/2914	79/9376	0.570202340512411	GSTT1/GSTM3/CYP1B1/HSD11B1/ALDH3B1/MGST1/ADH1B/CBR3/CYP2A6/GSTO1/CYP2A7/HSD11B1L/ADH5/CYP3A5	-2.57604301954538
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/2914	23/9376	0.279788726089941	GLUD1/ATP1B3	-2.32217690377242
NA	NA	hsa04082	Neuroactive ligand signaling	44/2914	199/9376	0.711422589957336	GNG4/P2RY14/HTR2B/ADRA2C/ADCY1/PRKACB/GNAI2/GNG11/GNB5/PRKCA/ADCY3/GABRA2/GNB2/HRH1/OGFR/ADORA1/PRKACA/GNB1/GNG2/GNA11/ADCY7/GRIA3/GNAO1/GNB4/GRIA4/GNAQ/P2RY1/GABBR1/P2RY11/GRIK2/ADORA2B/TAC3/PLCB2/SLC1A1/ADCY9/GABRE/POMC/SLC17A9/SLC6A12/GNGT2/P2RY13/ADCY6/GNB3/GNAL	-2.7630289719468
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	5/2914	41/9376	0.392386628052966	GABRA2/GRIA3/GRIA4/GABRE/CACNA1A	-2.61823741831226
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	11/2914	70/9376	0.505618197862536	GSTT1/GSTM3/CYP1B1/HSD11B1/MGST1/CYP2A6/GSTO1/CYP2A7/HSD11B1L/NAT1/CYP3A5	-2.78789817305434
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	10/2914	66/9376	0.487510659096109	CYP1B1/HSD11B1/HSD17B11/HSD17B12/CYP7B1/SRD5A1/HSD17B6/HSD11B1L/RDH5/CYP3A5	-2.80562032725253
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	2/2914	26/9376	0.247505411541101	HES1/HHEX	-2.58006819220728
NA	NA	hsa04382	Cornified envelope formation	46/2914	217/9376	0.68206560415474	S100A16/DST/SPTLC2/S100A6/ABHD5/S100A13/S100A3/TJP1/COL4A4/S100A4/COL7A1/PPP2R3C/PPP2R5E/SPTLC1/PPP2R5B/PPP2CA/PPP2CB/PLEC/CLDN10/PPP2R2D/KRT34/UGCG/SLC27A4/S100A1/ELOVL4/LAMA3/KDSR/SLC27A1/COL4A3/KRT10/S100A2/CLDN23/PPP2R3A/TGM1/COL4A6/ST14/LAMB3/CLDN12/COL17A1/TMEM79/KRT86/GBA2/CLDN15/KRT81/PPL/EPHX2	-3.18192755272794
Organismal Systems	Digestive system	hsa04976	Bile secretion	14/2914	90/9376	0.500510943338672	ADCY1/SLC4A2/PRKACB/ABCC3/ADCY3/PRKACA/NCEH1/SCARB1/ADCY7/ATP1B3/ABCC4/ADCY9/AQP9/ADCY6	-3.19727379219775
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	3/2914	36/9376	0.26813086250286	POLD4/RNASEH1/RFC1	-2.95432439713647
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	25/2914	143/9376	0.562512298957048	C3/HLA-DPB1/HLA-DQA2/HLA-DRA/C1S/C2/HLA-DPA1/C1QB/HLA-DMB/C1QA/FCGR3A/HLA-DMA/C1R/HLA-DQA1/C1QC/HLA-DRB1/CD86/HLA-DQB1/FCGR1A/FCGR2A/CD40/HLA-DOA/IL10/C5/HLA-DRB5	-3.54004990451472
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/2914	26/9376	0.123752705770551	ACAA1	-3.00437744938358
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	23/2914	138/9376	0.536261725005719	COX6C/ATP6V1D/ATP6V0A1/ATP6V0D1/COX7A1/SDHD/ATP6V0E1/ATP6V1H/LHPP/NDUFS1/ATP6V1C1/TCIRG1/ATP6V1G1/NDUFS2/ATP6AP1/COX7A2L/COX11/ATP6V0B/ATP6V1B2/UQCRB/ATP6V1E2/ATP6V1G2/NDUFA4L2	-3.68527958652713
Organismal Systems	Sensory system	hsa04742	Taste transduction	11/2914	86/9376	0.411549695934622	PRKACB/GABRA2/PRKACA/P2RY1/GABBR1/PLCB2/CACNA1C/ADCY6/GNB3/CACNA1A/TAS2R14	-3.68127359126922
Genetic Information Processing	Transcription	hsa03040	Spliceosome	41/2914	243/9376	0.542882240129247	RBMX2/SLU7/NCBP2/CRNKL1/PLRG1/DDX42/SRSF10/THOC2/SF1/CDC40/PRPF38B/PPIE/SF3B4/SNRNP27/PRPF6/PCBP1/ISY1/SNW1/ACIN1/DDX39B/USP39/PRPF8/SF3B5/SF3B1/BUD31/THOC5/SRSF4/AQR/CASC3/BUD13/GPKOW/PRPF18/PQBP1/U2AF1L4/DHX8/DDX5/SNIP1/SYF2/HNRNPA1L2/HSPA1A/HSPA6	-4.84809853234787
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	63/2914	370/9376	0.547856573113951	PRLR/C3/P2RY14/HTR2B/F2R/ADRA2C/VIPR2/S1PR3/PRL/LPAR1/TBXA2R/BDKRB2/TSPO/EDNRA/CNR1/PTGIR/RXFP1/EDNRB/FPR3/THRA/GABRA2/OXT/HRH1/BDKRB1/OGFR/PGRMC1/ADORA1/C3AR1/PGRMC2/LPAR6/PTGER4/CHRNB1/GRIA3/PTAFR/GRIA4/AGTR1/CSH1/OXTR/P2RY1/GABBR1/NR3C1/LEPR/P2RY11/AVPR1A/GRIK2/ADORA2B/TAC3/CSH2/C5AR1/AGT/GABRE/F2RL3/LYPD6/POMC/P2RX7/S1PR4/PTGER2/ADRB3/GPR35/P2RY13/C5/NMB/FPR1	-5.95878954890139
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	20/2914	183/9376	0.351647032790636	POP4/SBDS/XRN1/XRN2/MPHOSPH10/CSNK2A1/REXO2/RPP25/GNL2/NXT1/GTPBP4/MDN1/WDR3/FCF1/SNORD3D/UTP14C/TBL3/NOL6/SNORD3B-2/SNORD3B-1	-5.94778625087858
Genetic Information Processing	Translation	hsa03010	Ribosome	12/2914	222/9376	0.173922721623477	MRPS6/MRPS18A/MRPL33/MRPL50/MRPL43/MRPS10/MRPL36/RPL36AL/MRPL54/RPS4Y1/MRPL10/MRPL41	-8.36447418438234
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	12/2914	449/9376	0.0859929714931221	RGS2/CALM2/PRKACB/ADCY3/PRKACA/GNB1/SLC8A1/CAMK2D/ARRB2/ARRB1/PRKG1/GNAL	-13.3280579867427