ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003712 transcription coregulator activity 245/6355 495/18639 0.494949494949495 1.45167012373936 6.31891935745836e-13 8.70747087457762e-10 GO:0004674 protein serine/threonine kinase activity 213/6355 433/18639 0.491916859122402 1.44277550545751 4.23114487236688e-11 2.91525881706078e-08 GO:0044389 ubiquitin-like protein ligase binding 165/6355 322/18639 0.512422360248447 1.5029174465257 1.33685110293666e-10 3.78535315173124e-08 GO:0019787 ubiquitin-like protein transferase activity 230/6355 479/18639 0.480167014613779 1.40831360903009 1.35295183750459e-10 3.78535315173124e-08 GO:0051020 GTPase binding 162/6355 315/18639 0.514285714285714 1.5083826008767 1.37349533807374e-10 3.78535315173124e-08 GO:0106310 protein serine kinase activity 180/6355 361/18639 0.498614958448753 1.46242080417409 3.47946983056895e-10 7.16025124832104e-08 GO:0031267 small GTPase binding 147/6355 283/18639 0.519434628975265 1.52348419346498 3.92366475989923e-10 7.16025124832104e-08 GO:0016755 aminoacyltransferase activity 235/6355 496/18639 0.473790322580645 1.38961098703079 4.15689477406156e-10 7.16025124832104e-08 GO:0140297 DNA-binding transcription factor binding 231/6355 488/18639 0.473360655737705 1.38835078871677 6.49525245602669e-10 9.94495320489419e-08 GO:0031625 ubiquitin protein ligase binding 154/6355 302/18639 0.509933774834437 1.4956185096993 8.58866426701876e-10 1.18351793599519e-07 GO:0060589 nucleoside-triphosphatase regulator activity 230/6355 490/18639 0.469387755102041 1.37669840556207 1.82071822552478e-09 2.2808633770665e-07 GO:0030695 GTPase regulator activity 229/6355 489/18639 0.468302658486708 1.37351585389988 2.54669243940581e-09 2.92445181791767e-07 GO:0140996 histone H3 kinase activity 175/6355 357/18639 0.490196078431373 1.43772851390753 3.18152873937247e-09 3.37242046373482e-07 GO:0035173 histone kinase activity 176/6355 360/18639 0.488888888888889 1.43389457120378 3.70079054135569e-09 3.6426352614201e-07 GO:0004842 ubiquitin-protein transferase activity 212/6355 449/18639 0.472160356347439 1.3848303512132 4.26281395312883e-09 3.91610508494102e-07 GO:0141003 histone H2AX kinase activity 173/6355 354/18639 0.488700564971751 1.43334222352612 5.19878265360237e-09 4.47745156041504e-07 GO:0001221 transcription coregulator binding 69/6355 115/18639 0.6 1.75977970102282 1.11899854902811e-08 9.07047059153375e-07 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 168/6355 349/18639 0.481375358166189 1.41185763978908 3.28554900907419e-08 2.5152702969468e-06 GO:0035091 phosphatidylinositol binding 141/6355 284/18639 0.496478873239437 1.4561557385224 3.8782342254217e-08 2.81274040138479e-06 GO:0019902 phosphatase binding 101/6355 190/18639 0.531578947368421 1.55910306845004 4.63021499030089e-08 3.19021812831731e-06 GO:0001217 DNA-binding transcription repressor activity 138/6355 278/18639 0.496402877697842 1.45593284616996 5.45220561819743e-08 3.57768540089336e-06 GO:0003714 transcription corepressor activity 106/6355 204/18639 0.519607843137255 1.52399222474198 1.02520025369624e-07 6.421481589061e-06 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 132/6355 268/18639 0.492537313432836 1.44459527695903 1.86497150987662e-07 1.11736119156956e-05 GO:0032182 ubiquitin-like protein binding 68/6355 120/18639 0.566666666666667 1.6620141620771 3.17736440318702e-07 1.82433672816321e-05 GO:0061659 ubiquitin-like protein ligase activity 172/6355 372/18639 0.462365591397849 1.35610263698891 6.70056460690105e-07 3.69335121132386e-05 GO:0003713 transcription coactivator activity 125/6355 256/18639 0.48828125 1.43211238690008 7.02661452297605e-07 3.72410569717731e-05 GO:0140857 histone H3T45 kinase activity 120/6355 246/18639 0.48780487804878 1.43071520408359 1.2373474363198e-06 5.26722696884708e-05 GO:0035402 histone H3T11 kinase activity 120/6355 247/18639 0.48582995951417 1.42492283483629 1.60456744118551e-06 5.26722696884708e-05 GO:0035403 histone H3T6 kinase activity 120/6355 247/18639 0.48582995951417 1.42492283483629 1.60456744118551e-06 5.26722696884708e-05 GO:0005085 guanyl-nucleotide exchange factor activity 113/6355 230/18639 0.491304347826087 1.44097903054767 1.60960269219433e-06 5.26722696884708e-05 GO:0004676 3-phosphoinositide-dependent protein kinase activity 119/6355 245/18639 0.485714285714286 1.42458356749466 1.79651427819893e-06 5.26722696884708e-05 GO:0004711 ribosomal protein S6 kinase activity 119/6355 245/18639 0.485714285714286 1.42458356749466 1.79651427819893e-06 5.26722696884708e-05 GO:0035175 histone H3S10 kinase activity 119/6355 245/18639 0.485714285714286 1.42458356749466 1.79651427819893e-06 5.26722696884708e-05 GO:0035979 histone H2AXS139 kinase activity 119/6355 245/18639 0.485714285714286 1.42458356749466 1.79651427819893e-06 5.26722696884708e-05 GO:0044022 histone H3S28 kinase activity 119/6355 245/18639 0.485714285714286 1.42458356749466 1.79651427819893e-06 5.26722696884708e-05 GO:0044023 histone H4S1 kinase activity 119/6355 245/18639 0.485714285714286 1.42458356749466 1.79651427819893e-06 5.26722696884708e-05 GO:0044024 histone H2AS1 kinase activity 119/6355 245/18639 0.485714285714286 1.42458356749466 1.79651427819893e-06 5.26722696884708e-05 GO:0044025 histone H2BS14 kinase activity 119/6355 245/18639 0.485714285714286 1.42458356749466 1.79651427819893e-06 5.26722696884708e-05 GO:0072354 histone H3T3 kinase activity 119/6355 245/18639 0.485714285714286 1.42458356749466 1.79651427819893e-06 5.26722696884708e-05 GO:0072371 histone H2AS121 kinase activity 119/6355 245/18639 0.485714285714286 1.42458356749466 1.79651427819893e-06 5.26722696884708e-05 GO:0072518 Rho-dependent protein serine/threonine kinase activity 119/6355 245/18639 0.485714285714286 1.42458356749466 1.79651427819893e-06 5.26722696884708e-05 GO:0140823 histone H2BS36 kinase activity 119/6355 245/18639 0.485714285714286 1.42458356749466 1.79651427819893e-06 5.26722696884708e-05 GO:0140855 histone H3S57 kinase activity 119/6355 245/18639 0.485714285714286 1.42458356749466 1.79651427819893e-06 5.26722696884708e-05 GO:0140995 histone H2A kinase activity 119/6355 245/18639 0.485714285714286 1.42458356749466 1.79651427819893e-06 5.26722696884708e-05 GO:0140997 histone H4 kinase activity 119/6355 245/18639 0.485714285714286 1.42458356749466 1.79651427819893e-06 5.26722696884708e-05 GO:0140998 histone H2B kinase activity 119/6355 245/18639 0.485714285714286 1.42458356749466 1.79651427819893e-06 5.26722696884708e-05 GO:1990244 histone H2AT120 kinase activity 119/6355 245/18639 0.485714285714286 1.42458356749466 1.79651427819893e-06 5.26722696884708e-05 GO:0003779 actin binding 198/6355 443/18639 0.446952595936795 1.31089684274837 1.86146527748424e-06 5.34395656744433e-05 GO:0004679 AMP-activated protein kinase activity 120/6355 248/18639 0.483870967741935 1.41917717824421 2.0729608488961e-06 5.82967357097721e-05 GO:0004677 DNA-dependent protein kinase activity 119/6355 246/18639 0.483739837398374 1.41879257738289 2.32045801192824e-06 6.39518228087423e-05 GO:0046332 SMAD binding 47/6355 79/18639 0.594936708860759 1.74492923941081 3.29649697471878e-06 8.90700555129898e-05 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 117/6355 243/18639 0.481481481481481 1.41216889588251 3.73976768613396e-06 9.91038436825499e-05 GO:0001223 transcription coactivator binding 30/6355 44/18639 0.681818181818182 1.9997496602532 4.04232380757001e-06 0.00010510041899682 GO:0061630 ubiquitin protein ligase activity 160/6355 353/18639 0.453257790368272 1.3293897647009 6.7319415243641e-06 0.000171789174455069 GO:0005518 collagen binding 43/6355 72/18639 0.597222222222222 1.75163257277734 7.43698404918947e-06 0.000186330254905147 GO:0005096 GTPase activator activity 127/6355 271/18639 0.468634686346863 1.37448968038067 8.18689817005984e-06 0.000201456172827544 GO:0051019 mitogen-activated protein kinase binding 21/6355 28/18639 0.75 2.19972462627852 1.15120724791472e-05 0.000278309401337979 GO:0043130 ubiquitin binding 55/6355 100/18639 0.55 1.61313139260425 1.38285568609251e-05 0.000328547437144048 GO:0005543 phospholipid binding 214/6355 497/18639 0.430583501006036 1.2628868411096 1.60629504164594e-05 0.000375165180913238 GO:0019207 kinase regulator activity 132/6355 287/18639 0.45993031358885 1.34896004956453 1.74876765675296e-05 0.000401633638500931 GO:0001222 transcription corepressor binding 31/6355 49/18639 0.63265306122449 1.855550024888 2.81951596091556e-05 0.000625310843132947 GO:0019903 protein phosphatase binding 73/6355 144/18639 0.506944444444444 1.48685090479937 2.82905576249733e-05 0.000625310843132947 GO:1901981 phosphatidylinositol phosphate binding 90/6355 185/18639 0.486486486486487 1.42684840623472 2.85882315800984e-05 0.000625310843132947 GO:0140030 modification-dependent protein binding 85/6355 173/18639 0.491329479768786 1.44105274168535 2.97354623109916e-05 0.000640241672883538 GO:0005178 integrin binding 80/6355 161/18639 0.496894409937888 1.45737449360068 3.03621356141275e-05 0.000643677275019504 GO:0050840 extracellular matrix binding 39/6355 67/18639 0.582089552238806 1.70724896367885 4.4402199435871e-05 0.000927064103373186 GO:0050431 transforming growth factor beta binding 18/6355 24/18639 0.75 2.19972462627852 5.01890482828017e-05 0.00103224639602538 GO:0001540 amyloid-beta binding 46/6355 83/18639 0.55421686746988 1.62549932222991 5.28361464230559e-05 0.00107070896722016 GO:0019955 cytokine binding 72/6355 144/18639 0.5 1.46648308418568 5.71905361186845e-05 0.00114072981892728 GO:0019887 protein kinase regulator activity 117/6355 255/18639 0.458823529411765 1.34571388901745 5.79470880442014e-05 0.00114072981892728 GO:0001968 fibronectin binding 21/6355 30/18639 0.7 2.05307631785995 6.39222890506104e-05 0.00124063259594002 GO:0004713 protein tyrosine kinase activity 70/6355 140/18639 0.5 1.46648308418568 7.19718221004857e-05 0.00137746070631207 GO:0019003 GDP binding 42/6355 75/18639 0.56 1.64246105428796 7.99263866413836e-05 0.00150874740810721 GO:0005525 GTP binding 164/6355 378/18639 0.433862433862434 1.27250384024578 9.42662592583983e-05 0.00175539061159558 GO:0048156 tau protein binding 27/6355 43/18639 0.627906976744186 1.84162991967504 0.00011143063423844 0.00204735218640761 GO:0035401 histone H3Y41 kinase activity 58/6355 115/18639 0.504347826086956 1.47923511100469 0.000214435474161137 0.00383755952459801 GO:0140801 histone H2AXY142 kinase activity 58/6355 115/18639 0.504347826086956 1.47923511100469 0.000214435474161137 0.00383755952459801 GO:0016922 nuclear receptor binding 67/6355 137/18639 0.489051094890511 1.43437031591884 0.000233882804725353 0.0041319295501479 GO:0050321 tau-protein kinase activity 16/6355 22/18639 0.727272727272727 2.13306630427008 0.0002450967232236 0.00427523145065976 GO:0005201 extracellular matrix structural constituent 79/6355 168/18639 0.470238095238095 1.37919242441272 0.00033924962512717 0.0058435747928155 GO:0019001 guanyl nucleotide binding 169/6355 400/18639 0.4225 1.2391782061369 0.000367574517226825 0.00617704493583616 GO:0032561 guanyl ribonucleotide binding 169/6355 400/18639 0.4225 1.2391782061369 0.000367574517226825 0.00617704493583616 GO:0042393 histone binding 110/6355 247/18639 0.445344129554656 1.3061792652666 0.000393761731339424 0.00653739356368344 GO:0004725 protein tyrosine phosphatase activity 50/6355 98/18639 0.510204081632653 1.49641131039355 0.000400130766890055 0.00656404996160114 GO:0099122 RNA polymerase II C-terminal domain binding 9/6355 10/18639 0.9 2.63966955153423 0.000430146854865049 0.0069734396000475 GO:0023023 MHC protein complex binding 23/6355 37/18639 0.621621621621622 1.82319518574436 0.000442146238636514 0.00708462228885019 GO:0003924 GTPase activity 142/6355 331/18639 0.429003021148036 1.25825134715629 0.00048226467821886 0.00763862904121367 GO:0000149 SNARE binding 53/6355 106/18639 0.5 1.46648308418568 0.000514354252161535 0.00805431999407494 GO:0019838 growth factor binding 65/6355 136/18639 0.477941176470588 1.40178530105984 0.000636280420797935 0.00985162269505117 GO:0001098 basal transcription machinery binding 33/6355 60/18639 0.55 1.61313139260425 0.000698590027030857 0.010578648980753 GO:0001099 basal RNA polymerase II transcription machinery binding 33/6355 60/18639 0.55 1.61313139260425 0.000698590027030857 0.010578648980753 GO:0005161 platelet-derived growth factor receptor binding 11/6355 14/18639 0.785714285714286 2.30447341800607 0.000856143353525311 0.0128235384908465 GO:0008175 tRNA methyltransferase activity 21/6355 34/18639 0.617647058823529 1.81153792752349 0.000882281561596809 0.0130729461492516 GO:0004715 non-membrane spanning protein tyrosine kinase activity 26/6355 45/18639 0.577777777777778 1.69460267505901 0.000948232264896064 0.0139006815002848 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 12/6355 16/18639 0.75 2.19972462627852 0.000993531205856122 0.0144114315965235 GO:0004712 protein serine/threonine/tyrosine kinase activity 25/6355 43/18639 0.581395348837209 1.705212888588 0.00104418506273256 0.0148133835422756 GO:0032934 sterol binding 36/6355 68/18639 0.529411764705882 1.55274679502013 0.0010509912350697 0.0148133835422756 GO:0019789 SUMO transferase activity 18/6355 28/18639 0.642857142857143 1.88547825109588 0.0010534917178106 0.0148133835422756 GO:0016004 phospholipase activator activity 14/6355 20/18639 0.7 2.05307631785995 0.00112769171354638 0.0155488939680956 GO:0035035 histone acetyltransferase binding 16/6355 24/18639 0.666666666666667 1.95531077891424 0.00112836676110999 0.0155488939680956 GO:0035591 signaling adaptor activity 61/6355 129/18639 0.472868217054264 1.38690648271824 0.00127994295865677 0.0174629841290003 GO:0140034 methylation-dependent protein binding 39/6355 76/18639 0.513157894736842 1.50507474429583 0.00144715559837191 0.0195507883780048 GO:0004197 cysteine-type endopeptidase activity 44/6355 88/18639 0.5 1.46648308418568 0.00147658967757622 0.019754762870874 GO:0051219 phosphoprotein binding 46/6355 93/18639 0.494623655913978 1.45071444887186 0.00155402606123234 0.0205908453113285 GO:0042578 phosphoric ester hydrolase activity 151/6355 363/18639 0.415977961432507 1.22004928766963 0.00158412424359361 0.0207897448349713 GO:0140296 general transcription initiation factor binding 29/6355 53/18639 0.547169811320755 1.60483054495791 0.00160909764088117 0.0209182693314552 GO:0019107 myristoyltransferase activity 9/6355 11/18639 0.818181818181818 2.39969959230384 0.00164372719172345 0.0211687483195787 GO:0019209 kinase activator activity 68/6355 148/18639 0.459459459459459 1.34757905033279 0.00179874936037235 0.0229507094314175 GO:0004860 protein kinase inhibitor activity 42/6355 84/18639 0.5 1.46648308418568 0.00187000040783603 0.0236409225871381 GO:0016417 S-acyltransferase activity 18/6355 29/18639 0.620689655172414 1.82046175967878 0.00189592019694675 0.0237507093762965 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 44/6355 89/18639 0.49438202247191 1.45000574616112 0.00196711013785701 0.0242024800889907 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 44/6355 89/18639 0.49438202247191 1.45000574616112 0.00196711013785701 0.0242024800889907 GO:0002020 protease binding 63/6355 136/18639 0.463235294117647 1.35865344564262 0.00203137541908555 0.0247719940486716 GO:0097110 scaffold protein binding 36/6355 70/18639 0.514285714285714 1.5083826008767 0.0020617938882731 0.0249223857722837 GO:0019706 protein-cysteine S-palmitoyltransferase activity 16/6355 25/18639 0.64 1.87709834775767 0.00214531233574309 0.0252670119543075 GO:0019707 protein-cysteine S-acyltransferase activity 16/6355 25/18639 0.64 1.87709834775767 0.00214531233574309 0.0252670119543075 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 16/6355 25/18639 0.64 1.87709834775767 0.00214531233574309 0.0252670119543075 GO:0005158 insulin receptor binding 15/6355 23/18639 0.652173913043478 1.91280402285089 0.00224806955321144 0.0262528800366556 GO:0032977 membrane insertase activity 12/6355 17/18639 0.705882352941177 2.07032906002684 0.00232854906864679 0.026739505138294 GO:0051787 misfolded protein binding 12/6355 17/18639 0.705882352941177 2.07032906002684 0.00232854906864679 0.026739505138294 GO:0015485 cholesterol binding 29/6355 54/18639 0.537037037037037 1.57511146079203 0.00235406504710792 0.0268091044207828 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 99/6355 229/18639 0.432314410480349 1.26796354003827 0.00238924578839728 0.026986727019766 GO:1990782 protein tyrosine kinase binding 55/6355 117/18639 0.47008547008547 1.37874478000363 0.00253678488785631 0.0284202404509431 GO:0019210 kinase inhibitor activity 44/6355 90/18639 0.488888888888889 1.43389457120378 0.0025932787916605 0.0285883053992653 GO:0140793 histone H2AXY142 phosphatase activity 44/6355 90/18639 0.488888888888889 1.43389457120378 0.0025932787916605 0.0285883053992653 GO:0070063 RNA polymerase binding 31/6355 59/18639 0.525423728813559 1.5410500206697 0.00266622484256375 0.029159189151213 GO:0030971 receptor tyrosine kinase binding 40/6355 81/18639 0.493827160493827 1.44837835475129 0.00315940478163488 0.0342807857408887 GO:0016791 phosphatase activity 115/6355 273/18639 0.421245421245421 1.23549856909416 0.00327987153244169 0.0353098669664426 GO:0032266 phosphatidylinositol-3-phosphate binding 26/6355 48/18639 0.541666666666667 1.58869000786782 0.00332469925879225 0.0355150044853932 GO:0140313 molecular sequestering activity 29/6355 55/18639 0.527272727272727 1.54647307059581 0.00337465235568688 0.0356388953756565 GO:0035064 methylated histone binding 37/6355 74/18639 0.5 1.46648308418568 0.00338802270987736 0.0356388953756565 GO:0033218 amide binding 105/6355 247/18639 0.425101214574899 1.24680748048175 0.00343452848344922 0.035713543801257 GO:0016407 acetyltransferase activity 46/6355 96/18639 0.479166666666667 1.40537962234461 0.00346102537888702 0.035713543801257 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 22/6355 39/18639 0.564102564102564 1.65449373600436 0.00347287000679857 0.035713543801257 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 31/6355 60/18639 0.516666666666667 1.51536585365854 0.00373527158669594 0.038002298941053 GO:0005160 transforming growth factor beta receptor binding 16/6355 26/18639 0.615384615384615 1.8049022574593 0.00382187391958071 0.038002298941053 GO:0043548 phosphatidylinositol 3-kinase binding 16/6355 26/18639 0.615384615384615 1.8049022574593 0.00382187391958071 0.038002298941053 GO:0050681 nuclear androgen receptor binding 16/6355 26/18639 0.615384615384615 1.8049022574593 0.00382187391958071 0.038002298941053 GO:0030295 protein kinase activator activity 63/6355 139/18639 0.453237410071942 1.32932998998126 0.00383332333295092 0.038002298941053 GO:0004721 phosphoprotein phosphatase activity 77/6355 175/18639 0.44 1.2905051140834 0.00396796529950121 0.0390561155908047 GO:0060229 lipase activator activity 15/6355 24/18639 0.625 1.8331038552321 0.00411424087338052 0.0402086803086409 GO:0140035 ubiquitin-like protein reader activity 14/6355 22/18639 0.636363636363636 1.86643301623632 0.00439192155616262 0.0426201965098034 GO:0008603 cAMP-dependent protein kinase regulator activity 9/6355 12/18639 0.75 2.19972462627852 0.00457761042610617 0.0441115186515685 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 13/6355 20/18639 0.65 1.90642800944138 0.00463678207528331 0.0443714284704194 GO:0043175 RNA polymerase core enzyme binding 23/6355 42/18639 0.547619047619048 1.60614813982241 0.00469022449465479 0.0445358331622411 GO:0005545 1-phosphatidylinositol binding 10/6355 14/18639 0.714285714285714 2.09497583455097 0.00485434086555552 0.0445358331622411 GO:0008191 metalloendopeptidase inhibitor activity 10/6355 14/18639 0.714285714285714 2.09497583455097 0.00485434086555552 0.0445358331622411 GO:0046030 inositol trisphosphate phosphatase activity 10/6355 14/18639 0.714285714285714 2.09497583455097 0.00485434086555552 0.0445358331622411 GO:0071933 Arp2/3 complex binding 10/6355 14/18639 0.714285714285714 2.09497583455097 0.00485434086555552 0.0445358331622411 GO:0004707 MAP kinase activity 11/6355 16/18639 0.6875 2.01641424075531 0.00491251570439814 0.0445358331622411 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 11/6355 16/18639 0.6875 2.01641424075531 0.00491251570439814 0.0445358331622411 GO:0070411 I-SMAD binding 11/6355 16/18639 0.6875 2.01641424075531 0.00491251570439814 0.0445358331622411 GO:0019905 syntaxin binding 31/6355 61/18639 0.508196721311475 1.49052379048381 0.00514559160923099 0.0463439558007863 GO:0070325 lipoprotein particle receptor binding 18/6355 31/18639 0.580645161290323 1.70301261389305 0.00528180686415905 0.0472618822000725 GO:0003925 G protein activity 28/6355 54/18639 0.518518518518518 1.52079727248885 0.00535194953105606 0.0475401996868141 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 192/6355 484/18639 0.396694214876033 1.16349071142004 0.00541081045380143 0.0475401996868141 GO:0001784 phosphotyrosine residue binding 25/6355 47/18639 0.531914893617021 1.56008838743157 0.00541640881772846 0.0475401996868141 GO:0031593 polyubiquitin modification-dependent protein binding 30/6355 59/18639 0.508474576271186 1.49133872968035 0.00580660247196703 0.0500458619179968 GO:0045309 protein phosphorylated amino acid binding 30/6355 59/18639 0.508474576271186 1.49133872968035 0.00580660247196703 0.0500458619179968 GO:0140789 histone phosphatase activity 61/6355 136/18639 0.448529411764706 1.31552159022539 0.00581084028075434 0.0500458619179968 GO:0030159 signaling receptor complex adaptor activity 27/6355 52/18639 0.519230769230769 1.52288627973128 0.00603722317582562 0.0516726306601721 GO:0140597 protein carrier chaperone 81/6355 188/18639 0.430851063829787 1.26367159381958 0.00620539258199576 0.0527841418394454 GO:0023026 MHC class II protein complex binding 16/6355 27/18639 0.592592592592593 1.73805402570155 0.00643505746617617 0.054401896861293 GO:0000993 RNA polymerase II complex binding 20/6355 36/18639 0.555555555555556 1.6294256490952 0.00659985741432796 0.054458703694275 GO:0005484 SNAP receptor activity 20/6355 36/18639 0.555555555555556 1.6294256490952 0.00659985741432796 0.054458703694275 GO:0016409 palmitoyltransferase activity 20/6355 36/18639 0.555555555555556 1.6294256490952 0.00659985741432796 0.054458703694275 GO:0044390 ubiquitin-like protein conjugating enzyme binding 20/6355 36/18639 0.555555555555556 1.6294256490952 0.00659985741432796 0.054458703694275 GO:0000030 mannosyltransferase activity 15/6355 25/18639 0.6 1.75977970102282 0.00706763367983666 0.0576283976971297 GO:0042974 nuclear retinoic acid receptor binding 15/6355 25/18639 0.6 1.75977970102282 0.00706763367983666 0.0576283976971297 GO:0042169 SH2 domain binding 22/6355 41/18639 0.536585365853659 1.57378672449195 0.00773607049320412 0.0625727641847771 GO:0140098 catalytic activity, acting on RNA 155/6355 387/18639 0.400516795865633 1.1747022121384 0.00776483503308918 0.0625727641847771 GO:0008234 cysteine-type peptidase activity 80/6355 187/18639 0.427807486631016 1.25474488486475 0.00802855927301368 0.0643218295244933 GO:0001216 DNA-binding transcription activator activity 193/6355 491/18639 0.393075356415479 1.15287672198711 0.00819776184896918 0.0652977793519048 GO:0051010 microtubule plus-end binding 13/6355 21/18639 0.619047619047619 1.81564572327751 0.00839674723737294 0.0664983775465512 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 57/6355 128/18639 0.4453125 1.30608649685287 0.00893394069947899 0.0703484016221831 GO:0031624 ubiquitin conjugating enzyme binding 17/6355 30/18639 0.566666666666667 1.6620141620771 0.0092377686481936 0.0723275295296067 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 11/6355 17/18639 0.647058823529412 1.89780163835794 0.00964978786994229 0.0738744871376693 GO:0019198 transmembrane receptor protein phosphatase activity 11/6355 17/18639 0.647058823529412 1.89780163835794 0.00964978786994229 0.0738744871376693 GO:0032183 SUMO binding 11/6355 17/18639 0.647058823529412 1.89780163835794 0.00964978786994229 0.0738744871376693 GO:0046965 nuclear retinoid X receptor binding 11/6355 17/18639 0.647058823529412 1.89780163835794 0.00964978786994229 0.0738744871376693 GO:0043394 proteoglycan binding 20/6355 37/18639 0.540540540540541 1.58538711803857 0.00981754148887546 0.0747434926611623 GO:0051213 dioxygenase activity 43/6355 93/18639 0.462365591397849 1.35610263698891 0.0100183497972646 0.0751630743893573 GO:0031005 filamin binding 10/6355 15/18639 0.666666666666667 1.95531077891424 0.0101265948733655 0.0751630743893573 GO:0120283 protein serine/threonine kinase binding 10/6355 15/18639 0.666666666666667 1.95531077891424 0.0101265948733655 0.0751630743893573 GO:0032794 GTPase activating protein binding 8/6355 11/18639 0.727272727272727 2.13306630427008 0.0102544687846148 0.0751630743893573 GO:0034713 type I transforming growth factor beta receptor binding 8/6355 11/18639 0.727272727272727 2.13306630427008 0.0102544687846148 0.0751630743893573 GO:0140031 phosphorylation-dependent protein binding 8/6355 11/18639 0.727272727272727 2.13306630427008 0.0102544687846148 0.0751630743893573 GO:0180030 inositol phosphate kinase activity 8/6355 11/18639 0.727272727272727 2.13306630427008 0.0102544687846148 0.0751630743893573 GO:0046966 nuclear thyroid hormone receptor binding 16/6355 28/18639 0.571428571428571 1.67598066764078 0.0103121853273181 0.0751861977833035 GO:0031994 insulin-like growth factor I binding 9/6355 13/18639 0.692307692307692 2.03051503964171 0.0103806415102508 0.0752869684269771 GO:0140566 histone reader activity 19/6355 35/18639 0.542857142857143 1.59218163425874 0.011061118489751 0.0798022056485704 GO:0008198 ferrous iron binding 15/6355 26/18639 0.576923076923077 1.69209586636809 0.0114936697165494 0.0820636107223058 GO:0050750 low-density lipoprotein particle receptor binding 15/6355 26/18639 0.576923076923077 1.69209586636809 0.0114936697165494 0.0820636107223058 GO:0042826 histone deacetylase binding 56/6355 127/18639 0.440944881889764 1.29327642069918 0.0119817507234095 0.0851074870972078 GO:0071889 14-3-3 protein binding 18/6355 33/18639 0.545454545454545 1.59979972820256 0.0124626445309342 0.0880693546852687 GO:0004518 nuclease activity 87/6355 209/18639 0.416267942583732 1.22089979257564 0.0135276089307542 0.0951073729927516 GO:0043178 alcohol binding 42/6355 92/18639 0.456521739130435 1.33896281599562 0.0139777519515316 0.0977733106051297 GO:0017124 SH3 domain binding 51/6355 115/18639 0.443478260869565 1.3007067355386 0.0140799880022329 0.0979910276114996 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 13/6355 22/18639 0.590909090909091 1.73311637221944 0.0141814954435656 0.0982015111619771 GO:0005516 calmodulin binding 86/6355 207/18639 0.415458937198068 1.21852700714945 0.0148019210398397 0.101985235964496 GO:0043236 laminin binding 16/6355 29/18639 0.551724137931034 1.61818823082558 0.0158186193515888 0.108448047096962 GO:0034212 protein N-acetyltransferase activity 26/6355 53/18639 0.490566037735849 1.43881359203123 0.0172057635276525 0.115854331310081 GO:0051018 protein kinase A binding 26/6355 53/18639 0.490566037735849 1.43881359203123 0.0172057635276525 0.115854331310081 GO:0008409 5'-3' exonuclease activity 11/6355 18/18639 0.611111111111111 1.79236821400472 0.0172352234532414 0.115854331310081 GO:0070064 proline-rich region binding 11/6355 18/18639 0.611111111111111 1.79236821400472 0.0172352234532414 0.115854331310081 GO:0001727 lipid kinase activity 21/6355 41/18639 0.51219512195122 1.50225096428777 0.0175736625786354 0.117555859385241 GO:0061775 cohesin loader activity 65/6355 153/18639 0.42483660130719 1.24603137871986 0.0184664322234883 0.12230872434069 GO:0030291 protein serine/threonine kinase inhibitor activity 23/6355 46/18639 0.5 1.46648308418568 0.0186950442313522 0.12230872434069 GO:0004708 MAP kinase kinase activity 10/6355 16/18639 0.625 1.8331038552321 0.0188167268216446 0.12230872434069 GO:0005024 transforming growth factor beta receptor activity 10/6355 16/18639 0.625 1.8331038552321 0.0188167268216446 0.12230872434069 GO:0005159 insulin-like growth factor receptor binding 10/6355 16/18639 0.625 1.8331038552321 0.0188167268216446 0.12230872434069 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 10/6355 16/18639 0.625 1.8331038552321 0.0188167268216446 0.12230872434069 GO:0004709 MAP kinase kinase kinase activity 14/6355 25/18639 0.56 1.64246105428796 0.0200602586265911 0.129685000556611 GO:0004705 JUN kinase activity 9/6355 14/18639 0.642857142857143 1.88547825109588 0.0203279826707024 0.129685000556611 GO:0042813 Wnt receptor activity 9/6355 14/18639 0.642857142857143 1.88547825109588 0.0203279826707024 0.129685000556611 GO:0061665 SUMO ligase activity 9/6355 14/18639 0.642857142857143 1.88547825109588 0.0203279826707024 0.129685000556611 GO:0035497 cAMP response element binding 8/6355 12/18639 0.666666666666667 1.95531077891424 0.021608185501632 0.134359406118865 GO:0051117 ATPase binding 38/6355 84/18639 0.452380952380952 1.32681802854895 0.0220261725166335 0.134359406118865 GO:0004862 cAMP-dependent protein kinase inhibitor activity 7/6355 10/18639 0.7 2.05307631785995 0.0223697826990673 0.134359406118865 GO:0005131 growth hormone receptor binding 7/6355 10/18639 0.7 2.05307631785995 0.0223697826990673 0.134359406118865 GO:0005522 profilin binding 7/6355 10/18639 0.7 2.05307631785995 0.0223697826990673 0.134359406118865 GO:0005528 FK506 binding 7/6355 10/18639 0.7 2.05307631785995 0.0223697826990673 0.134359406118865 GO:0008239 dipeptidyl-peptidase activity 7/6355 10/18639 0.7 2.05307631785995 0.0223697826990673 0.134359406118865 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 7/6355 10/18639 0.7 2.05307631785995 0.0223697826990673 0.134359406118865 GO:0032395 MHC class II receptor activity 7/6355 10/18639 0.7 2.05307631785995 0.0223697826990673 0.134359406118865 GO:0042975 peroxisome proliferator activated receptor binding 7/6355 10/18639 0.7 2.05307631785995 0.0223697826990673 0.134359406118865 GO:0043422 protein kinase B binding 7/6355 10/18639 0.7 2.05307631785995 0.0223697826990673 0.134359406118865 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 13/6355 23/18639 0.565217391304348 1.65776348647077 0.0225725963356661 0.134359406118865 GO:0042171 lysophosphatidic acid acyltransferase activity 13/6355 23/18639 0.565217391304348 1.65776348647077 0.0225725963356661 0.134359406118865 GO:0071617 lysophospholipid acyltransferase activity 13/6355 23/18639 0.565217391304348 1.65776348647077 0.0225725963356661 0.134359406118865 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 13/6355 23/18639 0.565217391304348 1.65776348647077 0.0225725963356661 0.134359406118865 GO:0140463 chromatin-protein adaptor activity 26/6355 54/18639 0.481481481481481 1.41216889588251 0.0226207418139164 0.134359406118865 GO:0008080 N-acetyltransferase activity 32/6355 69/18639 0.463768115942029 1.3602161940273 0.0229238404621632 0.135575331145326 GO:0001965 G-protein alpha-subunit binding 16/6355 30/18639 0.533333333333333 1.56424862313139 0.0233395915840406 0.137444261550461 GO:0140674 ATP-dependent histone chaperone activity 64/6355 152/18639 0.421052631578947 1.23493312352478 0.0236740195978251 0.138820421301289 GO:0015631 tubulin binding 150/6355 385/18639 0.38961038961039 1.14271409157326 0.0246247263844936 0.143783359990815 GO:0061733 protein-lysine-acetyltransferase activity 23/6355 47/18639 0.48936170212766 1.43528131643705 0.0250218181447046 0.145485508031236 GO:0008017 microtubule binding 110/6355 276/18639 0.398550724637681 1.16893579174221 0.0254033460158203 0.146789993947075 GO:0005080 protein kinase C binding 25/6355 52/18639 0.480769230769231 1.41007988864008 0.0256054118629172 0.146789993947075 GO:0043015 gamma-tubulin binding 18/6355 35/18639 0.514285714285714 1.5083826008767 0.0256992263334724 0.146789993947075 GO:0061631 ubiquitin conjugating enzyme activity 18/6355 35/18639 0.514285714285714 1.5083826008767 0.0256992263334724 0.146789993947075 GO:0008173 RNA methyltransferase activity 31/6355 67/18639 0.462686567164179 1.35704404805242 0.0258119300586242 0.146789993947075 GO:0005496 steroid binding 47/6355 108/18639 0.435185185185185 1.27638342512457 0.0258853182359501 0.146789993947075 GO:0140658 ATP-dependent chromatin remodeler activity 66/6355 158/18639 0.417721518987342 1.22516308299057 0.0262517489361574 0.148257828008299 GO:0051015 actin filament binding 85/6355 209/18639 0.406698564593301 1.19283313067735 0.0271263493448357 0.152462976938376 GO:0061791 GTPase motor activity 20/6355 40/18639 0.5 1.46648308418568 0.0273282694512183 0.152462976938376 GO:1990606 membrane scission GTPase motor activity 20/6355 40/18639 0.5 1.46648308418568 0.0273282694512183 0.152462976938376 GO:0042605 peptide antigen binding 22/6355 45/18639 0.488888888888889 1.43389457120378 0.0283862029544764 0.156399202847503 GO:0005520 insulin-like growth factor binding 11/6355 19/18639 0.578947368421053 1.69803304484658 0.0284878083561126 0.156399202847503 GO:0043395 heparan sulfate proteoglycan binding 11/6355 19/18639 0.578947368421053 1.69803304484658 0.0284878083561126 0.156399202847503 GO:0140036 ubiquitin-modified protein reader activity 11/6355 19/18639 0.578947368421053 1.69803304484658 0.0284878083561126 0.156399202847503 GO:0015605 organophosphate ester transmembrane transporter activity 24/6355 50/18639 0.48 1.40782376081825 0.0290002673505874 0.157287985774223 GO:0038024 cargo receptor activity 30/6355 65/18639 0.461538461538462 1.35367669309447 0.0290703838512059 0.157287985774223 GO:0004519 endonuclease activity 54/6355 127/18639 0.425196850393701 1.24708797710278 0.0291185409165981 0.157287985774223 GO:0019783 ubiquitin-like protein peptidase activity 54/6355 127/18639 0.425196850393701 1.24708797710278 0.0291185409165981 0.157287985774223 GO:0140311 protein sequestering activity 17/6355 33/18639 0.515151515151515 1.51092196552464 0.0292204095487671 0.157287985774223 GO:0005112 Notch binding 14/6355 26/18639 0.538461538461538 1.57928947527689 0.0300546123549732 0.157796529960433 GO:0015216 purine nucleotide transmembrane transporter activity 14/6355 26/18639 0.538461538461538 1.57928947527689 0.0300546123549732 0.157796529960433 GO:0097602 cullin family protein binding 14/6355 26/18639 0.538461538461538 1.57928947527689 0.0300546123549732 0.157796529960433 GO:0000510 H3-H4 histone complex chaperone activity 63/6355 151/18639 0.417218543046358 1.22368787157216 0.030116463990997 0.157796529960433 GO:0140584 chromatin extrusion motor activity 63/6355 151/18639 0.417218543046358 1.22368787157216 0.030116463990997 0.157796529960433 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 63/6355 151/18639 0.417218543046358 1.22368787157216 0.030116463990997 0.157796529960433 GO:0140849 ATP-dependent H2AZ histone chaperone activity 63/6355 151/18639 0.417218543046358 1.22368787157216 0.030116463990997 0.157796529960433 GO:0043539 protein serine/threonine kinase activator activity 33/6355 73/18639 0.452054794520548 1.32586141857883 0.0316788350316586 0.164086655477634 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 10/6355 17/18639 0.588235294117647 1.72527421668904 0.031912353895505 0.164086655477634 GO:0008429 phosphatidylethanolamine binding 10/6355 17/18639 0.588235294117647 1.72527421668904 0.031912353895505 0.164086655477634 GO:0008484 sulfuric ester hydrolase activity 10/6355 17/18639 0.588235294117647 1.72527421668904 0.031912353895505 0.164086655477634 GO:0048038 quinone binding 10/6355 17/18639 0.588235294117647 1.72527421668904 0.031912353895505 0.164086655477634 GO:0017147 Wnt-protein binding 16/6355 31/18639 0.516129032258065 1.51378899012715 0.0332576236429565 0.170368049739755 GO:0001091 RNA polymerase II general transcription initiation factor binding 13/6355 24/18639 0.541666666666667 1.58869000786782 0.0341404781384249 0.174242884721294 GO:0140104 molecular carrier activity 99/6355 249/18639 0.397590361445783 1.16611907899102 0.0346519869483336 0.175679021163775 GO:0015616 DNA translocase activity 63/6355 152/18639 0.414473684210526 1.21563729346971 0.0346768459771747 0.175679021163775 GO:0061578 K63-linked deubiquitinase activity 9/6355 15/18639 0.6 1.75977970102282 0.0356300643667076 0.178539013444811 GO:0141050 histone H3K deacetylase activity 9/6355 15/18639 0.6 1.75977970102282 0.0356300643667076 0.178539013444811 GO:0141051 histone H4K deacetylase activity 9/6355 15/18639 0.6 1.75977970102282 0.0356300643667076 0.178539013444811 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 20/6355 41/18639 0.48780487804878 1.43071520408359 0.0366183712346306 0.182166482170834 GO:0061650 ubiquitin-like protein conjugating enzyme activity 20/6355 41/18639 0.48780487804878 1.43071520408359 0.0366183712346306 0.182166482170834 GO:0015026 coreceptor activity 28/6355 61/18639 0.459016393442623 1.34627955269505 0.0368994895942828 0.18290466424792 GO:0004407 histone deacetylase activity 12/6355 22/18639 0.545454545454545 1.59979972820256 0.038809766814878 0.190666323823238 GO:0033558 protein lysine deacetylase activity 12/6355 22/18639 0.545454545454545 1.59979972820256 0.038809766814878 0.190666323823238 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 8/6355 13/18639 0.615384615384615 1.8049022574593 0.0395722558878419 0.190666323823238 GO:0005172 vascular endothelial growth factor receptor binding 8/6355 13/18639 0.615384615384615 1.8049022574593 0.0395722558878419 0.190666323823238 GO:0005338 nucleotide-sugar transmembrane transporter activity 8/6355 13/18639 0.615384615384615 1.8049022574593 0.0395722558878419 0.190666323823238 GO:0017154 semaphorin receptor activity 8/6355 13/18639 0.615384615384615 1.8049022574593 0.0395722558878419 0.190666323823238 GO:0035325 Toll-like receptor binding 8/6355 13/18639 0.615384615384615 1.8049022574593 0.0395722558878419 0.190666323823238 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 8/6355 13/18639 0.615384615384615 1.8049022574593 0.0395722558878419 0.190666323823238 GO:0030332 cyclin binding 17/6355 34/18639 0.5 1.46648308418568 0.0402697625122612 0.192679627576027 GO:0052866 phosphatidylinositol phosphate phosphatase activity 17/6355 34/18639 0.5 1.46648308418568 0.0402697625122612 0.192679627576027 GO:0004536 DNA nuclease activity 29/6355 64/18639 0.453125 1.32900029504327 0.0408247355205967 0.194659119541115 GO:0140713 histone chaperone activity 67/6355 164/18639 0.408536585365854 1.19822398342001 0.0412931962659044 0.196213877429022 GO:0140375 immune receptor activity 64/6355 156/18639 0.41025641025641 1.20326817163953 0.0415173105259901 0.196531781424857 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 19/6355 39/18639 0.487179487179487 1.42888095382195 0.041645341201784 0.196531781424857 GO:0005044 scavenger receptor activity 14/6355 27/18639 0.518518518518518 1.52079727248885 0.0432336494746965 0.200138800213389 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 14/6355 27/18639 0.518518518518518 1.52079727248885 0.0432336494746965 0.200138800213389 GO:0003953 NAD+ nucleosidase activity 7/6355 11/18639 0.636363636363636 1.86643301623632 0.0435715820493591 0.200138800213389 GO:0005114 type II transforming growth factor beta receptor binding 7/6355 11/18639 0.636363636363636 1.86643301623632 0.0435715820493591 0.200138800213389 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 7/6355 11/18639 0.636363636363636 1.86643301623632 0.0435715820493591 0.200138800213389 GO:0042608 T cell receptor binding 7/6355 11/18639 0.636363636363636 1.86643301623632 0.0435715820493591 0.200138800213389 GO:0048185 activin binding 7/6355 11/18639 0.636363636363636 1.86643301623632 0.0435715820493591 0.200138800213389 GO:0097493 structural molecule activity conferring elasticity 7/6355 11/18639 0.636363636363636 1.86643301623632 0.0435715820493591 0.200138800213389 GO:0008013 beta-catenin binding 45/6355 106/18639 0.424528301886792 1.24512714695011 0.0445479108235576 0.203943591743729 GO:0022884 macromolecule transmembrane transporter activity 16/6355 32/18639 0.5 1.46648308418568 0.0459276257766357 0.208632748234707 GO:0120015 sterol transfer activity 16/6355 32/18639 0.5 1.46648308418568 0.0459276257766357 0.208632748234707 GO:0042277 peptide binding 98/6355 249/18639 0.393574297188755 1.15434009839515 0.0460263827745652 0.208632748234707 GO:0019213 deacetylase activity 18/6355 37/18639 0.486486486486487 1.42684840623472 0.0474095123723321 0.214197731308438 GO:0019208 phosphatase regulator activity 49/6355 117/18639 0.418803418803419 1.22833625854869 0.0476180219446587 0.214436713201764 GO:0016859 cis-trans isomerase activity 20/6355 42/18639 0.476190476190476 1.39665055636731 0.04803432320642 0.214967814118805 GO:0140938 histone H3 methyltransferase activity 22/6355 47/18639 0.468085106382979 1.37287778093979 0.0480479584532598 0.214967814118805 GO:0003689 DNA clamp loader activity 65/6355 160/18639 0.40625 1.19151750590087 0.0491843340702875 0.219339845789179 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 10/6355 18/18639 0.555555555555556 1.6294256490952 0.0502587669483345 0.223408325338081 GO:0098531 ligand-modulated transcription factor activity 27/6355 60/18639 0.45 1.31983477576711 0.051663833707344 0.228915636169518 GO:0140101 catalytic activity, acting on a tRNA 57/6355 139/18639 0.410071942446043 1.20272713379257 0.052369449552456 0.229962263116915 GO:0140767 enzyme-substrate adaptor activity 57/6355 139/18639 0.410071942446043 1.20272713379257 0.052369449552456 0.229962263116915 GO:0015215 nucleotide transmembrane transporter activity 15/6355 30/18639 0.5 1.46648308418568 0.0524507364711646 0.229962263116915 GO:0031072 heat shock protein binding 54/6355 131/18639 0.412213740458015 1.20900895490117 0.0525675710318058 0.229962263116915 GO:0008238 exopeptidase activity 43/6355 102/18639 0.42156862745098 1.23644652196048 0.0544955286401563 0.236595156674235 GO:0004177 aminopeptidase activity 19/6355 40/18639 0.475 1.3931589299764 0.0545988823094388 0.236595156674235 GO:0032451 demethylase activity 19/6355 40/18639 0.475 1.3931589299764 0.0545988823094388 0.236595156674235 GO:0000295 adenine nucleotide transmembrane transporter activity 12/6355 23/18639 0.521739130434783 1.53024321828071 0.0565230437012908 0.244165373731595 GO:0005521 lamin binding 9/6355 16/18639 0.5625 1.64979346970889 0.0572472126389315 0.246520809426399 GO:1902936 phosphatidylinositol bisphosphate binding 46/6355 111/18639 0.414414414414414 1.21546345716291 0.0636187899376323 0.273104961165287 GO:0008237 metallopeptidase activity 73/6355 184/18639 0.396739130434783 1.16362244723429 0.0646726704817624 0.274889031410002 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 11/6355 21/18639 0.523809523809524 1.53631561200405 0.0648003150332219 0.274889031410002 GO:0034236 protein kinase A catalytic subunit binding 8/6355 14/18639 0.571428571428571 1.67598066764078 0.0652312868440279 0.274889031410002 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 8/6355 14/18639 0.571428571428571 1.67598066764078 0.0652312868440279 0.274889031410002 GO:0042043 neurexin family protein binding 8/6355 14/18639 0.571428571428571 1.67598066764078 0.0652312868440279 0.274889031410002 GO:0098847 sequence-specific single stranded DNA binding 8/6355 14/18639 0.571428571428571 1.67598066764078 0.0652312868440279 0.274889031410002 GO:0003724 RNA helicase activity 33/6355 77/18639 0.428571428571429 1.25698550073058 0.067885968833658 0.284428660601134 GO:0004112 cyclic-nucleotide phosphodiesterase activity 13/6355 26/18639 0.5 1.46648308418568 0.0687334861975164 0.284428660601134 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 13/6355 26/18639 0.5 1.46648308418568 0.0687334861975164 0.284428660601134 GO:0008157 protein phosphatase 1 binding 13/6355 26/18639 0.5 1.46648308418568 0.0687334861975164 0.284428660601134 GO:0052742 phosphatidylinositol kinase activity 13/6355 26/18639 0.5 1.46648308418568 0.0687334861975164 0.284428660601134 GO:0070412 R-SMAD binding 13/6355 26/18639 0.5 1.46648308418568 0.0687334861975164 0.284428660601134 GO:0140318 protein transporter activity 19/6355 41/18639 0.463414634146341 1.35917944387941 0.0701275055104098 0.284973159596932 GO:0016411 acylglycerol O-acyltransferase activity 15/6355 31/18639 0.483870967741935 1.41917717824421 0.0704442797476097 0.284973159596932 GO:0140457 protein demethylase activity 15/6355 31/18639 0.483870967741935 1.41917717824421 0.0704442797476097 0.284973159596932 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 17/6355 36/18639 0.472222222222222 1.38501180173092 0.0707441557863669 0.284973159596932 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 17/6355 36/18639 0.472222222222222 1.38501180173092 0.0707441557863669 0.284973159596932 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 17/6355 36/18639 0.472222222222222 1.38501180173092 0.0707441557863669 0.284973159596932 GO:0008168 methyltransferase activity 80/6355 204/18639 0.392156862745098 1.15018281112602 0.0709124346311656 0.284973159596932 GO:0004879 nuclear receptor activity 26/6355 59/18639 0.440677966101695 1.29249356572297 0.0711673946450039 0.284973159596932 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 24/6355 54/18639 0.444444444444444 1.30354051927616 0.0736351210000486 0.284973159596932 GO:0000995 RNA polymerase III general transcription initiation factor activity 7/6355 12/18639 0.583333333333333 1.71089693154996 0.074320337216177 0.284973159596932 GO:0005025 transforming growth factor beta receptor activity, type I 7/6355 12/18639 0.583333333333333 1.71089693154996 0.074320337216177 0.284973159596932 GO:0005026 transforming growth factor beta receptor activity, type II 7/6355 12/18639 0.583333333333333 1.71089693154996 0.074320337216177 0.284973159596932 GO:0005527 macrolide binding 7/6355 12/18639 0.583333333333333 1.71089693154996 0.074320337216177 0.284973159596932 GO:0016361 activin receptor activity, type I 7/6355 12/18639 0.583333333333333 1.71089693154996 0.074320337216177 0.284973159596932 GO:0016362 activin receptor activity, type II 7/6355 12/18639 0.583333333333333 1.71089693154996 0.074320337216177 0.284973159596932 GO:0016840 carbon-nitrogen lyase activity 7/6355 12/18639 0.583333333333333 1.71089693154996 0.074320337216177 0.284973159596932 GO:0017002 activin receptor activity 7/6355 12/18639 0.583333333333333 1.71089693154996 0.074320337216177 0.284973159596932 GO:0035014 phosphatidylinositol 3-kinase regulator activity 7/6355 12/18639 0.583333333333333 1.71089693154996 0.074320337216177 0.284973159596932 GO:0070008 serine-type exopeptidase activity 7/6355 12/18639 0.583333333333333 1.71089693154996 0.074320337216177 0.284973159596932 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 7/6355 12/18639 0.583333333333333 1.71089693154996 0.074320337216177 0.284973159596932 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 7/6355 12/18639 0.583333333333333 1.71089693154996 0.074320337216177 0.284973159596932 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 7/6355 12/18639 0.583333333333333 1.71089693154996 0.074320337216177 0.284973159596932 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 7/6355 12/18639 0.583333333333333 1.71089693154996 0.074320337216177 0.284973159596932 GO:0141221 histone deacetylase activity, hydrolytic mechanism 7/6355 12/18639 0.583333333333333 1.71089693154996 0.074320337216177 0.284973159596932 GO:1990459 transferrin receptor binding 7/6355 12/18639 0.583333333333333 1.71089693154996 0.074320337216177 0.284973159596932 GO:0005346 purine ribonucleotide transmembrane transporter activity 10/6355 19/18639 0.526315789473684 1.54366640440598 0.0744487209396921 0.284973159596932 GO:0042800 histone H3K4 methyltransferase activity 10/6355 19/18639 0.526315789473684 1.54366640440598 0.0744487209396921 0.284973159596932 GO:0003725 double-stranded RNA binding 32/6355 75/18639 0.426666666666667 1.25139889850511 0.0755668452911239 0.288451836042019 GO:0001046 core promoter sequence-specific DNA binding 20/6355 44/18639 0.454545454545455 1.3331664401688 0.0780169189850925 0.296272287645799 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 12/6355 24/18639 0.5 1.46648308418568 0.078905609264157 0.296272287645799 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 12/6355 24/18639 0.5 1.46648308418568 0.078905609264157 0.296272287645799 GO:0042625 ATPase-coupled ion transmembrane transporter activity 12/6355 24/18639 0.5 1.46648308418568 0.078905609264157 0.296272287645799 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 12/6355 24/18639 0.5 1.46648308418568 0.078905609264157 0.296272287645799 GO:0046961 proton-transporting ATPase activity, rotational mechanism 12/6355 24/18639 0.5 1.46648308418568 0.078905609264157 0.296272287645799 GO:0000287 magnesium ion binding 89/6355 230/18639 0.38695652173913 1.13493038689153 0.0800696783311325 0.29949553101695 GO:0019199 transmembrane receptor protein kinase activity 33/6355 78/18639 0.423076923076923 1.24087030200327 0.0802726142112212 0.29949553101695 GO:0004222 metalloendopeptidase activity 45/6355 110/18639 0.409090909090909 1.19984979615192 0.0804160714631869 0.29949553101695 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 66/6355 167/18639 0.395209580838323 1.15913633001503 0.0812727704711522 0.299615156723336 GO:0120013 lipid transfer activity 28/6355 65/18639 0.430769230769231 1.26343158022151 0.0824948001148447 0.299615156723336 GO:0140097 catalytic activity, acting on DNA 127/6355 336/18639 0.37797619047619 1.10859137911656 0.0835302077072779 0.299615156723336 GO:0004090 carbonyl reductase (NADPH) activity 6/6355 10/18639 0.6 1.75977970102282 0.0845793149240768 0.299615156723336 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 6/6355 10/18639 0.6 1.75977970102282 0.0845793149240768 0.299615156723336 GO:0004445 inositol-polyphosphate 5-phosphatase activity 6/6355 10/18639 0.6 1.75977970102282 0.0845793149240768 0.299615156723336 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 6/6355 10/18639 0.6 1.75977970102282 0.0845793149240768 0.299615156723336 GO:0015279 store-operated calcium channel activity 6/6355 10/18639 0.6 1.75977970102282 0.0845793149240768 0.299615156723336 GO:0016427 tRNA (cytidine) methyltransferase activity 6/6355 10/18639 0.6 1.75977970102282 0.0845793149240768 0.299615156723336 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 6/6355 10/18639 0.6 1.75977970102282 0.0845793149240768 0.299615156723336 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 6/6355 10/18639 0.6 1.75977970102282 0.0845793149240768 0.299615156723336 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 6/6355 10/18639 0.6 1.75977970102282 0.0845793149240768 0.299615156723336 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 6/6355 10/18639 0.6 1.75977970102282 0.0845793149240768 0.299615156723336 GO:0051864 histone H3K36 demethylase activity 6/6355 10/18639 0.6 1.75977970102282 0.0845793149240768 0.299615156723336 GO:0070097 delta-catenin binding 6/6355 10/18639 0.6 1.75977970102282 0.0845793149240768 0.299615156723336 GO:0070513 death domain binding 6/6355 10/18639 0.6 1.75977970102282 0.0845793149240768 0.299615156723336 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 6/6355 10/18639 0.6 1.75977970102282 0.0845793149240768 0.299615156723336 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 6/6355 10/18639 0.6 1.75977970102282 0.0845793149240768 0.299615156723336 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 6/6355 10/18639 0.6 1.75977970102282 0.0845793149240768 0.299615156723336 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 9/6355 17/18639 0.529411764705882 1.55274679502013 0.0857489287252861 0.302204664407786 GO:0016805 dipeptidase activity 9/6355 17/18639 0.529411764705882 1.55274679502013 0.0857489287252861 0.302204664407786 GO:1990841 promoter-specific chromatin binding 29/6355 68/18639 0.426470588235294 1.25082380709955 0.0880553804491018 0.309100072691458 GO:0004402 histone acetyltransferase activity 19/6355 42/18639 0.452380952380952 1.32681802854895 0.0883783952397927 0.309100072691458 GO:0004520 DNA endonuclease activity 19/6355 42/18639 0.452380952380952 1.32681802854895 0.0883783952397927 0.309100072691458 GO:0031683 G-protein beta/gamma-subunit complex binding 11/6355 22/18639 0.5 1.46648308418568 0.0907908632515659 0.316733695090273 GO:0008320 protein transmembrane transporter activity 13/6355 27/18639 0.481481481481481 1.41216889588251 0.0924119060115635 0.321574763848319 GO:0004857 enzyme inhibitor activity 155/6355 416/18639 0.372596153846154 1.09281191369606 0.0932465121402816 0.323661697051154 GO:0008081 phosphoric diester hydrolase activity 36/6355 87/18639 0.413793103448276 1.21364117311918 0.0941197984471912 0.325063445847338 GO:0008186 ATP-dependent activity, acting on RNA 33/6355 79/18639 0.417721518987342 1.22516308299057 0.0941221443346066 0.325063445847338 GO:0046915 transition metal ion transmembrane transporter activity 20/6355 45/18639 0.444444444444444 1.30354051927616 0.0968587251715945 0.333678308216143 GO:0008170 N-methyltransferase activity 40/6355 98/18639 0.408163265306122 1.19712904831484 0.0978419668272268 0.336225013186829 GO:0005041 low-density lipoprotein particle receptor activity 8/6355 15/18639 0.533333333333333 1.56424862313139 0.0990612553895368 0.337887153284113 GO:0005523 tropomyosin binding 8/6355 15/18639 0.533333333333333 1.56424862313139 0.0990612553895368 0.337887153284113 GO:0047372 monoacylglycerol lipase activity 8/6355 15/18639 0.533333333333333 1.56424862313139 0.0990612553895368 0.337887153284113 GO:0015036 disulfide oxidoreductase activity 18/6355 40/18639 0.45 1.31983477576711 0.100175158609716 0.340003370847755 GO:0030331 nuclear estrogen receptor binding 18/6355 40/18639 0.45 1.31983477576711 0.100175158609716 0.340003370847755 GO:1901505 carbohydrate derivative transmembrane transporter activity 23/6355 53/18639 0.433962264150943 1.27279663910455 0.100721548675129 0.341017921558546 GO:0010485 histone H4 acetyltransferase activity 16/6355 35/18639 0.457142857142857 1.34078453411262 0.103081907597606 0.348154089876227 GO:0043022 ribosome binding 45/6355 112/18639 0.401785714285714 1.17842390693492 0.104380780654729 0.348662417601089 GO:0016408 C-acyltransferase activity 10/6355 20/18639 0.5 1.46648308418568 0.104747872495194 0.348662417601089 GO:0052745 inositol phosphate phosphatase activity 10/6355 20/18639 0.5 1.46648308418568 0.104747872495194 0.348662417601089 GO:0140693 molecular condensate scaffold activity 21/6355 48/18639 0.4375 1.28317269866247 0.105094500901321 0.348662417601089 GO:0032452 histone demethylase activity 14/6355 30/18639 0.466666666666667 1.36871754523997 0.105256578898442 0.348662417601089 GO:0043995 histone H4K5 acetyltransferase activity 14/6355 30/18639 0.466666666666667 1.36871754523997 0.105256578898442 0.348662417601089 GO:0043996 histone H4K8 acetyltransferase activity 14/6355 30/18639 0.466666666666667 1.36871754523997 0.105256578898442 0.348662417601089 GO:0043997 histone H4K12 acetyltransferase activity 14/6355 30/18639 0.466666666666667 1.36871754523997 0.105256578898442 0.348662417601089 GO:0017025 TBP-class protein binding 12/6355 25/18639 0.48 1.40782376081825 0.106147049252999 0.349094591576688 GO:0019211 phosphatase activator activity 12/6355 25/18639 0.48 1.40782376081825 0.106147049252999 0.349094591576688 GO:0120020 cholesterol transfer activity 12/6355 25/18639 0.48 1.40782376081825 0.106147049252999 0.349094591576688 GO:0005126 cytokine receptor binding 104/6355 275/18639 0.378181818181818 1.10919447822044 0.106613810462036 0.349794835277821 GO:0008375 acetylglucosaminyltransferase activity 19/6355 43/18639 0.441860465116279 1.29596179532688 0.109435811930707 0.358200828599798 GO:0016757 glycosyltransferase activity 101/6355 267/18639 0.378277153558052 1.10947409365359 0.109758230368015 0.358404837552427 GO:0042162 telomeric DNA binding 17/6355 38/18639 0.447368421052632 1.31211644374508 0.11361820749729 0.369216735332957 GO:0035673 oligopeptide transmembrane transporter activity 7/6355 13/18639 0.538461538461538 1.57928947527689 0.114859765432568 0.369216735332957 GO:0039706 co-receptor binding 7/6355 13/18639 0.538461538461538 1.57928947527689 0.114859765432568 0.369216735332957 GO:0046975 histone H3K36 methyltransferase activity 7/6355 13/18639 0.538461538461538 1.57928947527689 0.114859765432568 0.369216735332957 GO:0051011 microtubule minus-end binding 7/6355 13/18639 0.538461538461538 1.57928947527689 0.114859765432568 0.369216735332957 GO:0070123 transforming growth factor beta receptor activity, type III 7/6355 13/18639 0.538461538461538 1.57928947527689 0.114859765432568 0.369216735332957 GO:0001786 phosphatidylserine binding 25/6355 59/18639 0.423728813559322 1.24278227473363 0.114944832697996 0.369216735332957 GO:0016410 N-acyltransferase activity 38/6355 94/18639 0.404255319148936 1.185667174448 0.11800756982592 0.37817309586074 GO:0036408 histone H3K14 acetyltransferase activity 13/6355 28/18639 0.464285714285714 1.36173429245813 0.120509992193223 0.382305415817126 GO:0046875 ephrin receptor binding 13/6355 28/18639 0.464285714285714 1.36173429245813 0.120509992193223 0.382305415817126 GO:0141052 histone H3 demethylase activity 13/6355 28/18639 0.464285714285714 1.36173429245813 0.120509992193223 0.382305415817126 GO:0004706 JUN kinase kinase kinase activity 9/6355 18/18639 0.5 1.46648308418568 0.121239090502238 0.382305415817126 GO:0030228 lipoprotein particle receptor activity 9/6355 18/18639 0.5 1.46648308418568 0.121239090502238 0.382305415817126 GO:0034185 apolipoprotein binding 9/6355 18/18639 0.5 1.46648308418568 0.121239090502238 0.382305415817126 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 9/6355 18/18639 0.5 1.46648308418568 0.121239090502238 0.382305415817126 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 11/6355 23/18639 0.478260869565217 1.40272295009065 0.122203031172652 0.383589469147868 GO:0070577 lysine-acetylated histone binding 11/6355 23/18639 0.478260869565217 1.40272295009065 0.122203031172652 0.383589469147868 GO:0001618 virus receptor activity 33/6355 81/18639 0.407407407407407 1.19491214266981 0.126339822414717 0.388607757338126 GO:0033192 calmodulin-dependent protein phosphatase activity 33/6355 81/18639 0.407407407407407 1.19491214266981 0.126339822414717 0.388607757338126 GO:0140791 histone H2AXS140 phosphatase activity 33/6355 81/18639 0.407407407407407 1.19491214266981 0.126339822414717 0.388607757338126 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 33/6355 81/18639 0.407407407407407 1.19491214266981 0.126339822414717 0.388607757338126 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 33/6355 81/18639 0.407407407407407 1.19491214266981 0.126339822414717 0.388607757338126 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 33/6355 81/18639 0.407407407407407 1.19491214266981 0.126339822414717 0.388607757338126 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 33/6355 81/18639 0.407407407407407 1.19491214266981 0.126339822414717 0.388607757338126 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 33/6355 81/18639 0.407407407407407 1.19491214266981 0.126339822414717 0.388607757338126 GO:1990439 MAP kinase serine/threonine phosphatase activity 33/6355 81/18639 0.407407407407407 1.19491214266981 0.126339822414717 0.388607757338126 GO:0016504 peptidase activator activity 24/6355 57/18639 0.421052631578947 1.23493312352478 0.128309422934709 0.393787048561311 GO:0004386 helicase activity 60/6355 155/18639 0.387096774193548 1.13534174259537 0.129279385196219 0.395882206223089 GO:0004722 protein serine/threonine phosphatase activity 41/6355 103/18639 0.398058252427184 1.16749138740996 0.131466005067375 0.401325185902503 GO:0004527 exonuclease activity 34/6355 84/18639 0.404761904761905 1.18715297291222 0.131639320774987 0.401325185902503 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 6/6355 11/18639 0.545454545454545 1.59979972820256 0.133788594373738 0.402534242460724 GO:0008432 JUN kinase binding 6/6355 11/18639 0.545454545454545 1.59979972820256 0.133788594373738 0.402534242460724 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 6/6355 11/18639 0.545454545454545 1.59979972820256 0.133788594373738 0.402534242460724 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 6/6355 11/18639 0.545454545454545 1.59979972820256 0.133788594373738 0.402534242460724 GO:0047676 arachidonate-CoA ligase activity 6/6355 11/18639 0.545454545454545 1.59979972820256 0.133788594373738 0.402534242460724 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 6/6355 11/18639 0.545454545454545 1.59979972820256 0.133788594373738 0.402534242460724 GO:0005539 glycosaminoglycan binding 91/6355 242/18639 0.37603305785124 1.10289223686692 0.137986370342633 0.413148365800171 GO:0030507 spectrin binding 12/6355 26/18639 0.461538461538462 1.35367669309447 0.138215817586269 0.413148365800171 GO:0070006 metalloaminopeptidase activity 12/6355 26/18639 0.461538461538462 1.35367669309447 0.138215817586269 0.413148365800171 GO:0008142 oxysterol binding 8/6355 16/18639 0.5 1.46648308418568 0.140875298140142 0.417137259677745 GO:0015923 mannosidase activity 8/6355 16/18639 0.5 1.46648308418568 0.140875298140142 0.417137259677745 GO:0022858 alanine transmembrane transporter activity 8/6355 16/18639 0.5 1.46648308418568 0.140875298140142 0.417137259677745 GO:0008373 sialyltransferase activity 10/6355 21/18639 0.476190476190476 1.39665055636731 0.141063833824259 0.417137259677745 GO:0010314 phosphatidylinositol-5-phosphate binding 10/6355 21/18639 0.476190476190476 1.39665055636731 0.141063833824259 0.417137259677745 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 33/6355 82/18639 0.402439024390244 1.18034004336896 0.144724800825728 0.425225534195848 GO:0033549 MAP kinase phosphatase activity 33/6355 82/18639 0.402439024390244 1.18034004336896 0.144724800825728 0.425225534195848 GO:0140272 exogenous protein binding 33/6355 82/18639 0.402439024390244 1.18034004336896 0.144724800825728 0.425225534195848 GO:0101005 deubiquitinase activity 45/6355 115/18639 0.391304347826087 1.14768241371053 0.148403352602517 0.435105999758017 GO:0051879 Hsp90 protein binding 18/6355 42/18639 0.428571428571429 1.25698550073058 0.150174951686208 0.439365357587251 GO:0004896 cytokine receptor activity 38/6355 96/18639 0.395833333333333 1.16096577498033 0.151746207820088 0.44271320319747 GO:0019888 protein phosphatase regulator activity 42/6355 107/18639 0.392523364485981 1.15125774833268 0.152441089051994 0.44271320319747 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 13/6355 29/18639 0.448275862068966 1.31477793754578 0.152925605748908 0.44271320319747 GO:0010484 histone H3 acetyltransferase activity 13/6355 29/18639 0.448275862068966 1.31477793754578 0.152925605748908 0.44271320319747 GO:0097472 cyclin-dependent protein kinase activity 13/6355 29/18639 0.448275862068966 1.31477793754578 0.152925605748908 0.44271320319747 GO:0140033 acetylation-dependent protein binding 11/6355 24/18639 0.458333333333333 1.34427616050354 0.15883931124907 0.458869121386203 GO:0051539 4 iron, 4 sulfur cluster binding 19/6355 45/18639 0.422222222222222 1.23836349331235 0.159954688360059 0.461124603682346 GO:1990380 K48-linked deubiquitinase activity 9/6355 19/18639 0.473684210526316 1.38929976396538 0.163350423108529 0.463823961065691 GO:0043021 ribonucleoprotein complex binding 67/6355 177/18639 0.378531073446328 1.11021883209537 0.163421007486334 0.463823961065691 GO:0004065 arylsulfatase activity 7/6355 14/18639 0.5 1.46648308418568 0.164488244021108 0.463823961065691 GO:0005347 ATP transmembrane transporter activity 7/6355 14/18639 0.5 1.46648308418568 0.164488244021108 0.463823961065691 GO:0008174 mRNA methyltransferase activity 7/6355 14/18639 0.5 1.46648308418568 0.164488244021108 0.463823961065691 GO:0008331 high voltage-gated calcium channel activity 7/6355 14/18639 0.5 1.46648308418568 0.164488244021108 0.463823961065691 GO:0008559 ABC-type xenobiotic transporter activity 7/6355 14/18639 0.5 1.46648308418568 0.164488244021108 0.463823961065691 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 7/6355 14/18639 0.5 1.46648308418568 0.164488244021108 0.463823961065691 GO:0032454 histone H3K9 demethylase activity 7/6355 14/18639 0.5 1.46648308418568 0.164488244021108 0.463823961065691 GO:0098821 BMP receptor activity 7/6355 14/18639 0.5 1.46648308418568 0.164488244021108 0.463823961065691 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 33/6355 83/18639 0.397590361445783 1.16611907899102 0.164604196515132 0.463823961065691 GO:0016887 ATP hydrolysis activity 152/6355 417/18639 0.364508393285372 1.0690907855934 0.164930145807104 0.463823961065691 GO:0042562 hormone binding 37/6355 94/18639 0.393617021276596 1.15446540669937 0.165619685128081 0.464814513455186 GO:0008201 heparin binding 65/6355 172/18639 0.377906976744186 1.1083883775822 0.171741634004618 0.48101620255765 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 47/6355 122/18639 0.385245901639344 1.12991319601192 0.173375514849841 0.484607422846006 GO:0016779 nucleotidyltransferase activity 52/6355 136/18639 0.382352941176471 1.12142824084787 0.175465049375081 0.489455137730489 GO:0008093 cytoskeletal anchor activity 10/6355 22/18639 0.454545454545455 1.3331664401688 0.18295797596817 0.50524266710248 GO:0016881 acid-amino acid ligase activity 10/6355 22/18639 0.454545454545455 1.3331664401688 0.18295797596817 0.50524266710248 GO:0030021 extracellular matrix structural constituent conferring compression resistance 10/6355 22/18639 0.454545454545455 1.3331664401688 0.18295797596817 0.50524266710248 GO:0034062 5'-3' RNA polymerase activity 10/6355 22/18639 0.454545454545455 1.3331664401688 0.18295797596817 0.50524266710248 GO:0097747 RNA polymerase activity 10/6355 22/18639 0.454545454545455 1.3331664401688 0.18295797596817 0.50524266710248 GO:0016741 transferase activity, transferring one-carbon groups 80/6355 215/18639 0.372093023255814 1.09133624869632 0.184595796011569 0.508746013807885 GO:0004521 RNA endonuclease activity 29/6355 73/18639 0.397260273972603 1.16515094359958 0.185172490026589 0.50931674901525 GO:0017018 myosin phosphatase activity 33/6355 84/18639 0.392857142857143 1.15223670900303 0.185934410229345 0.510393659952264 GO:0070402 NADPH binding 8/6355 17/18639 0.470588235294118 1.38021937335123 0.189876515397792 0.516100661647541 GO:0070403 NAD+ binding 8/6355 17/18639 0.470588235294118 1.38021937335123 0.189876515397792 0.516100661647541 GO:0160215 deacylase activity 26/6355 65/18639 0.4 1.17318646734854 0.18992906477488 0.516100661647541 GO:0005109 frizzled binding 16/6355 38/18639 0.421052631578947 1.23493312352478 0.190604236289915 0.516100661647541 GO:0017022 myosin binding 30/6355 76/18639 0.394736842105263 1.15774980330448 0.19133898270849 0.516100661647541 GO:0004875 complement receptor activity 6/6355 12/18639 0.5 1.46648308418568 0.1932568515313 0.516100661647541 GO:0005165 neurotrophin receptor binding 6/6355 12/18639 0.5 1.46648308418568 0.1932568515313 0.516100661647541 GO:0016423 tRNA (guanine) methyltransferase activity 6/6355 12/18639 0.5 1.46648308418568 0.1932568515313 0.516100661647541 GO:0034452 dynactin binding 6/6355 12/18639 0.5 1.46648308418568 0.1932568515313 0.516100661647541 GO:0035251 UDP-glucosyltransferase activity 6/6355 12/18639 0.5 1.46648308418568 0.1932568515313 0.516100661647541 GO:0035259 nuclear glucocorticoid receptor binding 6/6355 12/18639 0.5 1.46648308418568 0.1932568515313 0.516100661647541 GO:0043047 single-stranded telomeric DNA binding 6/6355 12/18639 0.5 1.46648308418568 0.1932568515313 0.516100661647541 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 6/6355 12/18639 0.5 1.46648308418568 0.1932568515313 0.516100661647541 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 6/6355 12/18639 0.5 1.46648308418568 0.1932568515313 0.516100661647541 GO:0015932 nucleobase-containing compound transmembrane transporter activity 23/6355 57/18639 0.403508771929825 1.18347757671125 0.194419841480312 0.518202208046169 GO:0030145 manganese ion binding 27/6355 68/18639 0.397058823529412 1.1645600962651 0.196742307712753 0.523380115884506 GO:0003707 nuclear steroid receptor activity 11/6355 25/18639 0.44 1.2905051140834 0.200240374245983 0.530636991751856 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 11/6355 25/18639 0.44 1.2905051140834 0.200240374245983 0.530636991751856 GO:0019956 chemokine binding 14/6355 33/18639 0.424242424242424 1.24428867749088 0.202612561965224 0.534866111854556 GO:0140416 transcription regulator inhibitor activity 14/6355 33/18639 0.424242424242424 1.24428867749088 0.202612561965224 0.534866111854556 GO:0004540 RNA nuclease activity 46/6355 121/18639 0.380165289256198 1.11501193177754 0.206114661420423 0.543070752270254 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 9/6355 20/18639 0.45 1.31983477576711 0.21129796451944 0.551455672552629 GO:0016505 peptidase activator activity involved in apoptotic process 9/6355 20/18639 0.45 1.31983477576711 0.21129796451944 0.551455672552629 GO:0030742 GTP-dependent protein binding 9/6355 20/18639 0.45 1.31983477576711 0.21129796451944 0.551455672552629 GO:0031418 L-ascorbic acid binding 9/6355 20/18639 0.45 1.31983477576711 0.21129796451944 0.551455672552629 GO:0043024 ribosomal small subunit binding 9/6355 20/18639 0.45 1.31983477576711 0.21129796451944 0.551455672552629 GO:0008374 O-acyltransferase activity 22/6355 55/18639 0.4 1.17318646734854 0.21526848777081 0.560613723372669 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 12/6355 28/18639 0.428571428571429 1.25698550073058 0.215620662835642 0.560613723372669 GO:0004559 alpha-mannosidase activity 7/6355 15/18639 0.466666666666667 1.36871754523997 0.221736859073733 0.569273979078034 GO:0042809 nuclear vitamin D receptor binding 7/6355 15/18639 0.466666666666667 1.36871754523997 0.221736859073733 0.569273979078034 GO:0050780 dopamine receptor binding 7/6355 15/18639 0.466666666666667 1.36871754523997 0.221736859073733 0.569273979078034 GO:0051371 muscle alpha-actinin binding 7/6355 15/18639 0.466666666666667 1.36871754523997 0.221736859073733 0.569273979078034 GO:0004843 cysteine-type deubiquitinase activity 41/6355 108/18639 0.37962962962963 1.11344086021505 0.225685451599496 0.569273979078034 GO:0003774 cytoskeletal motor activity 57/6355 153/18639 0.372549019607843 1.09267367056972 0.227787573219317 0.569273979078034 GO:0005031 tumor necrosis factor receptor activity 5/6355 10/18639 0.5 1.46648308418568 0.228944616793013 0.569273979078034 GO:0005381 iron ion transmembrane transporter activity 5/6355 10/18639 0.5 1.46648308418568 0.228944616793013 0.569273979078034 GO:0008140 cAMP response element binding protein binding 5/6355 10/18639 0.5 1.46648308418568 0.228944616793013 0.569273979078034 GO:0008641 ubiquitin-like modifier activating enzyme activity 5/6355 10/18639 0.5 1.46648308418568 0.228944616793013 0.569273979078034 GO:0015643 toxic substance binding 5/6355 10/18639 0.5 1.46648308418568 0.228944616793013 0.569273979078034 GO:0016303 1-phosphatidylinositol-3-kinase activity 5/6355 10/18639 0.5 1.46648308418568 0.228944616793013 0.569273979078034 GO:0016783 sulfurtransferase activity 5/6355 10/18639 0.5 1.46648308418568 0.228944616793013 0.569273979078034 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 5/6355 10/18639 0.5 1.46648308418568 0.228944616793013 0.569273979078034 GO:0043208 glycosphingolipid binding 5/6355 10/18639 0.5 1.46648308418568 0.228944616793013 0.569273979078034 GO:0045322 unmethylated CpG binding 5/6355 10/18639 0.5 1.46648308418568 0.228944616793013 0.569273979078034 GO:0050815 phosphoserine residue binding 5/6355 10/18639 0.5 1.46648308418568 0.228944616793013 0.569273979078034 GO:0051880 G-quadruplex DNA binding 5/6355 10/18639 0.5 1.46648308418568 0.228944616793013 0.569273979078034 GO:0098505 G-rich strand telomeric DNA binding 5/6355 10/18639 0.5 1.46648308418568 0.228944616793013 0.569273979078034 GO:0140999 histone H3K4 trimethyltransferase activity 5/6355 10/18639 0.5 1.46648308418568 0.228944616793013 0.569273979078034 GO:0070851 growth factor receptor binding 52/6355 139/18639 0.37410071942446 1.09722475363533 0.22908003390227 0.569273979078034 GO:0070273 phosphatidylinositol-4-phosphate binding 13/6355 31/18639 0.419354838709677 1.22995355447831 0.22942767865492 0.569273979078034 GO:0016849 phosphorus-oxygen lyase activity 10/6355 23/18639 0.434782608695652 1.27520268190059 0.229692548887799 0.569273979078034 GO:0043274 phospholipase binding 10/6355 23/18639 0.434782608695652 1.27520268190059 0.229692548887799 0.569273979078034 GO:0044013 histone H2B acetyltransferase activity 10/6355 23/18639 0.434782608695652 1.27520268190059 0.229692548887799 0.569273979078034 GO:0140103 catalytic activity, acting on a glycoprotein 10/6355 23/18639 0.434782608695652 1.27520268190059 0.229692548887799 0.569273979078034 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 33/6355 86/18639 0.383720930232558 1.12544050646808 0.232669516058793 0.575616863786386 GO:0048487 beta-tubulin binding 17/6355 42/18639 0.404761904761905 1.18715297291222 0.236241623043703 0.583406732176027 GO:0004864 protein phosphatase inhibitor activity 21/6355 53/18639 0.39622641509434 1.16211867048677 0.238139011594893 0.585992067817433 GO:0005246 calcium channel regulator activity 21/6355 53/18639 0.39622641509434 1.16211867048677 0.238139011594893 0.585992067817433 GO:0015035 protein-disulfide reductase activity 14/6355 34/18639 0.411764705882353 1.20769195168233 0.241918769059968 0.594231842717711 GO:0000900 mRNA regulatory element binding translation repressor activity 8/6355 18/18639 0.444444444444444 1.30354051927616 0.244786455314235 0.595095110194779 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 8/6355 18/18639 0.444444444444444 1.30354051927616 0.244786455314235 0.595095110194779 GO:0017075 syntaxin-1 binding 8/6355 18/18639 0.444444444444444 1.30354051927616 0.244786455314235 0.595095110194779 GO:1990381 ubiquitin-specific protease binding 8/6355 18/18639 0.444444444444444 1.30354051927616 0.244786455314235 0.595095110194779 GO:0004435 phosphatidylinositol phospholipase C activity 11/6355 26/18639 0.423076923076923 1.24087030200327 0.245725049129774 0.595095110194779 GO:0004529 DNA exonuclease activity 11/6355 26/18639 0.423076923076923 1.24087030200327 0.245725049129774 0.595095110194779 GO:0030247 polysaccharide binding 11/6355 26/18639 0.423076923076923 1.24087030200327 0.245725049129774 0.595095110194779 GO:0034237 protein kinase A regulatory subunit binding 11/6355 26/18639 0.423076923076923 1.24087030200327 0.245725049129774 0.595095110194779 GO:0016278 lysine N-methyltransferase activity 27/6355 70/18639 0.385714285714286 1.13128695065753 0.25069826918723 0.606074061298251 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 19/6355 48/18639 0.395833333333333 1.16096577498033 0.254795155976196 0.614899693406652 GO:0004629 phospholipase C activity 12/6355 29/18639 0.413793103448276 1.21364117311918 0.259875997249806 0.616677147210414 GO:0051861 glycolipid binding 12/6355 29/18639 0.413793103448276 1.21364117311918 0.259875997249806 0.616677147210414 GO:0008035 high-density lipoprotein particle binding 6/6355 13/18639 0.461538461538462 1.35367669309447 0.260454353901641 0.616677147210414 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 6/6355 13/18639 0.461538461538462 1.35367669309447 0.260454353901641 0.616677147210414 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 6/6355 13/18639 0.461538461538462 1.35367669309447 0.260454353901641 0.616677147210414 GO:0046974 histone H3K9 methyltransferase activity 6/6355 13/18639 0.461538461538462 1.35367669309447 0.260454353901641 0.616677147210414 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 6/6355 13/18639 0.461538461538462 1.35367669309447 0.260454353901641 0.616677147210414 GO:0061459 L-arginine transmembrane transporter activity 6/6355 13/18639 0.461538461538462 1.35367669309447 0.260454353901641 0.616677147210414 GO:0089720 caspase binding 6/6355 13/18639 0.461538461538462 1.35367669309447 0.260454353901641 0.616677147210414 GO:0140333 glycerophospholipid flippase activity 6/6355 13/18639 0.461538461538462 1.35367669309447 0.260454353901641 0.616677147210414 GO:0140852 histone ubiquitin ligase activity 6/6355 13/18639 0.461538461538462 1.35367669309447 0.260454353901641 0.616677147210414 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 16/6355 40/18639 0.4 1.17318646734854 0.263726381269832 0.621804391762833 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 9/6355 21/18639 0.428571428571429 1.25698550073058 0.263973562540825 0.621804391762833 GO:0036122 BMP binding 9/6355 21/18639 0.428571428571429 1.25698550073058 0.263973562540825 0.621804391762833 GO:0005319 lipid transporter activity 65/6355 178/18639 0.365168539325843 1.07102697159628 0.270765394447248 0.636283170351351 GO:0051287 NAD binding 21/6355 54/18639 0.388888888888889 1.14059795436664 0.271043701738928 0.636283170351351 GO:0031369 translation initiation factor binding 13/6355 32/18639 0.40625 1.19151750590087 0.272500780881426 0.63861577560307 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 17/6355 43/18639 0.395348837209302 1.15954476423984 0.273337251600244 0.639200308771532 GO:0140223 general transcription initiation factor activity 26/6355 68/18639 0.382352941176471 1.12142824084787 0.273677926106824 0.639200308771532 GO:0070840 dynein complex binding 10/6355 24/18639 0.416666666666667 1.2220692368214 0.280302004344034 0.653563725864769 GO:0000062 fatty-acyl-CoA binding 7/6355 16/18639 0.4375 1.28317269866247 0.284629184244303 0.654789675940985 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 7/6355 16/18639 0.4375 1.28317269866247 0.284629184244303 0.654789675940985 GO:0005324 long-chain fatty acid transmembrane transporter activity 7/6355 16/18639 0.4375 1.28317269866247 0.284629184244303 0.654789675940985 GO:0016722 oxidoreductase activity, acting on metal ions 7/6355 16/18639 0.4375 1.28317269866247 0.284629184244303 0.654789675940985 GO:0034450 ubiquitin-ubiquitin ligase activity 7/6355 16/18639 0.4375 1.28317269866247 0.284629184244303 0.654789675940985 GO:0097027 ubiquitin-protein transferase activator activity 7/6355 16/18639 0.4375 1.28317269866247 0.284629184244303 0.654789675940985 GO:0140327 flippase activity 7/6355 16/18639 0.4375 1.28317269866247 0.284629184244303 0.654789675940985 GO:0140328 floppase activity 7/6355 16/18639 0.4375 1.28317269866247 0.284629184244303 0.654789675940985 GO:0004714 transmembrane receptor protein tyrosine kinase activity 23/6355 60/18639 0.383333333333333 1.12430369787569 0.285452075489506 0.655588266707566 GO:0031490 chromatin DNA binding 47/6355 128/18639 0.3671875 1.07694851494886 0.29406771418116 0.671764720781271 GO:0005385 zinc ion transmembrane transporter activity 11/6355 27/18639 0.407407407407407 1.19491214266981 0.294445494449846 0.671764720781271 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 11/6355 27/18639 0.407407407407407 1.19491214266981 0.294445494449846 0.671764720781271 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 11/6355 27/18639 0.407407407407407 1.19491214266981 0.294445494449846 0.671764720781271 GO:0008574 plus-end-directed microtubule motor activity 8/6355 19/18639 0.421052631578947 1.23493312352478 0.304012660554749 0.679610422963581 GO:0015245 fatty acid transmembrane transporter activity 8/6355 19/18639 0.421052631578947 1.23493312352478 0.304012660554749 0.679610422963581 GO:0046527 glucosyltransferase activity 8/6355 19/18639 0.421052631578947 1.23493312352478 0.304012660554749 0.679610422963581 GO:0097001 ceramide binding 8/6355 19/18639 0.421052631578947 1.23493312352478 0.304012660554749 0.679610422963581 GO:0002039 p53 binding 26/6355 69/18639 0.376811594202899 1.10517565764718 0.304343382062641 0.679610422963581 GO:0016279 protein-lysine N-methyltransferase activity 26/6355 69/18639 0.376811594202899 1.10517565764718 0.304343382062641 0.679610422963581 GO:0016758 hexosyltransferase activity 71/6355 197/18639 0.360406091370558 1.05705887286481 0.305288107012063 0.679610422963581 GO:0051721 protein phosphatase 2A binding 12/6355 30/18639 0.4 1.17318646734854 0.306874401424678 0.679610422963581 GO:0070566 adenylyltransferase activity 12/6355 30/18639 0.4 1.17318646734854 0.306874401424678 0.679610422963581 GO:0001851 complement component C3b binding 5/6355 11/18639 0.454545454545455 1.3331664401688 0.308241302142408 0.679610422963581 GO:0002162 dystroglycan binding 5/6355 11/18639 0.454545454545455 1.3331664401688 0.308241302142408 0.679610422963581 GO:0004016 adenylate cyclase activity 5/6355 11/18639 0.454545454545455 1.3331664401688 0.308241302142408 0.679610422963581 GO:0004143 ATP-dependent diacylglycerol kinase activity 5/6355 11/18639 0.454545454545455 1.3331664401688 0.308241302142408 0.679610422963581 GO:0008526 phosphatidylinositol transfer activity 5/6355 11/18639 0.454545454545455 1.3331664401688 0.308241302142408 0.679610422963581 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 5/6355 11/18639 0.454545454545455 1.3331664401688 0.308241302142408 0.679610422963581 GO:0019203 carbohydrate phosphatase activity 5/6355 11/18639 0.454545454545455 1.3331664401688 0.308241302142408 0.679610422963581 GO:0019864 IgG binding 5/6355 11/18639 0.454545454545455 1.3331664401688 0.308241302142408 0.679610422963581 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 5/6355 11/18639 0.454545454545455 1.3331664401688 0.308241302142408 0.679610422963581 GO:0045294 alpha-catenin binding 5/6355 11/18639 0.454545454545455 1.3331664401688 0.308241302142408 0.679610422963581 GO:0050998 nitric-oxide synthase binding 5/6355 11/18639 0.454545454545455 1.3331664401688 0.308241302142408 0.679610422963581 GO:0140537 transcription regulator activator activity 5/6355 11/18639 0.454545454545455 1.3331664401688 0.308241302142408 0.679610422963581 GO:0043014 alpha-tubulin binding 17/6355 44/18639 0.386363636363636 1.13319147414348 0.312280081277637 0.686376110412858 GO:0008408 3'-5' exonuclease activity 22/6355 58/18639 0.379310344827586 1.11250440869259 0.312306111196562 0.686376110412858 GO:0032931 histone H3K56 acetyltransferase activity 9/6355 22/18639 0.409090909090909 1.19984979615192 0.320061276321895 0.686412600028669 GO:0043992 histone H3K9 acetyltransferase activity 9/6355 22/18639 0.409090909090909 1.19984979615192 0.320061276321895 0.686412600028669 GO:0043993 histone H3K18 acetyltransferase activity 9/6355 22/18639 0.409090909090909 1.19984979615192 0.320061276321895 0.686412600028669 GO:0043994 histone H3K23 acetyltransferase activity 9/6355 22/18639 0.409090909090909 1.19984979615192 0.320061276321895 0.686412600028669 GO:0043999 histone H2AK5 acetyltransferase activity 9/6355 22/18639 0.409090909090909 1.19984979615192 0.320061276321895 0.686412600028669 GO:0044012 histone H2AK9 acetyltransferase activity 9/6355 22/18639 0.409090909090909 1.19984979615192 0.320061276321895 0.686412600028669 GO:0044014 histone H2BK5 acetyltransferase activity 9/6355 22/18639 0.409090909090909 1.19984979615192 0.320061276321895 0.686412600028669 GO:0044015 histone H2BK12 acetyltransferase activity 9/6355 22/18639 0.409090909090909 1.19984979615192 0.320061276321895 0.686412600028669 GO:0044016 histone H3K4 acetyltransferase activity 9/6355 22/18639 0.409090909090909 1.19984979615192 0.320061276321895 0.686412600028669 GO:0044017 histone H3K27 acetyltransferase activity 9/6355 22/18639 0.409090909090909 1.19984979615192 0.320061276321895 0.686412600028669 GO:0044018 histone H3K36 acetyltransferase activity 9/6355 22/18639 0.409090909090909 1.19984979615192 0.320061276321895 0.686412600028669 GO:0046972 histone H4K16 acetyltransferase activity 9/6355 22/18639 0.409090909090909 1.19984979615192 0.320061276321895 0.686412600028669 GO:0140908 histone H3K122 acetyltransferase activity 9/6355 22/18639 0.409090909090909 1.19984979615192 0.320061276321895 0.686412600028669 GO:0043495 protein-membrane adaptor activity 18/6355 47/18639 0.382978723404255 1.12326363895073 0.320292671856629 0.686412600028669 GO:0061749 forked DNA-dependent helicase activity 18/6355 47/18639 0.382978723404255 1.12326363895073 0.320292671856629 0.686412600028669 GO:1990518 single-stranded 3'-5' DNA helicase activity 18/6355 47/18639 0.382978723404255 1.12326363895073 0.320292671856629 0.686412600028669 GO:0042626 ATPase-coupled transmembrane transporter activity 36/6355 98/18639 0.36734693877551 1.07741614348336 0.324713768436783 0.694806790226534 GO:0004033 aldo-keto reductase (NADPH) activity 14/6355 36/18639 0.388888888888889 1.14059795436664 0.327858434266745 0.700438951434239 GO:0042054 histone methyltransferase activity 25/6355 67/18639 0.373134328358209 1.0943903613326 0.330568530720442 0.700438951434239 GO:0008474 palmitoyl-(protein) hydrolase activity 6/6355 14/18639 0.428571428571429 1.25698550073058 0.332428936312041 0.700438951434239 GO:0016530 metallochaperone activity 6/6355 14/18639 0.428571428571429 1.25698550073058 0.332428936312041 0.700438951434239 GO:0019992 diacylglycerol binding 6/6355 14/18639 0.428571428571429 1.25698550073058 0.332428936312041 0.700438951434239 GO:0031404 chloride ion binding 6/6355 14/18639 0.428571428571429 1.25698550073058 0.332428936312041 0.700438951434239 GO:0032036 myosin heavy chain binding 6/6355 14/18639 0.428571428571429 1.25698550073058 0.332428936312041 0.700438951434239 GO:0044548 S100 protein binding 6/6355 14/18639 0.428571428571429 1.25698550073058 0.332428936312041 0.700438951434239 GO:0070742 C2H2 zinc finger domain binding 6/6355 14/18639 0.428571428571429 1.25698550073058 0.332428936312041 0.700438951434239 GO:0098599 palmitoyl hydrolase activity 6/6355 14/18639 0.428571428571429 1.25698550073058 0.332428936312041 0.700438951434239 GO:0008094 ATP-dependent activity, acting on DNA 75/6355 210/18639 0.357142857142857 1.04748791727549 0.333353774460546 0.701315269017759 GO:0017046 peptide hormone binding 20/6355 53/18639 0.377358490566038 1.10677968617787 0.334676749719129 0.703025245599024 GO:0016776 phosphotransferase activity, phosphate group as acceptor 15/6355 39/18639 0.384615384615385 1.12806391091206 0.336856555697102 0.706527144217056 GO:0016798 hydrolase activity, acting on glycosyl bonds 47/6355 130/18639 0.361538461538462 1.06038007625734 0.340173515167762 0.712399853953155 GO:0019212 phosphatase inhibitor activity 21/6355 56/18639 0.375 1.09986231313926 0.341177068124095 0.713417298748107 GO:0019894 kinesin binding 16/6355 42/18639 0.380952380952381 1.11732044509385 0.345070681927754 0.719078278886636 GO:0035198 miRNA binding 16/6355 42/18639 0.380952380952381 1.11732044509385 0.345070681927754 0.719078278886636 GO:0097718 disordered domain specific binding 11/6355 28/18639 0.392857142857143 1.15223670900303 0.345449797259037 0.719078278886636 GO:0004029 aldehyde dehydrogenase (NAD+) activity 7/6355 17/18639 0.411764705882353 1.20769195168233 0.350956052436861 0.722896024301934 GO:0004549 tRNA-specific ribonuclease activity 7/6355 17/18639 0.411764705882353 1.20769195168233 0.350956052436861 0.722896024301934 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 7/6355 17/18639 0.411764705882353 1.20769195168233 0.350956052436861 0.722896024301934 GO:0015278 intracellularly gated calcium channel activity 7/6355 17/18639 0.411764705882353 1.20769195168233 0.350956052436861 0.722896024301934 GO:0030169 low-density lipoprotein particle binding 7/6355 17/18639 0.411764705882353 1.20769195168233 0.350956052436861 0.722896024301934 GO:1901567 fatty acid derivative binding 7/6355 17/18639 0.411764705882353 1.20769195168233 0.350956052436861 0.722896024301934 GO:1990226 histone methyltransferase binding 7/6355 17/18639 0.411764705882353 1.20769195168233 0.350956052436861 0.722896024301934 GO:0009378 four-way junction helicase activity 18/6355 48/18639 0.375 1.09986231313926 0.359591181384888 0.736280308987186 GO:0036121 double-stranded DNA helicase activity 18/6355 48/18639 0.375 1.09986231313926 0.359591181384888 0.736280308987186 GO:0038187 pattern recognition receptor activity 18/6355 48/18639 0.375 1.09986231313926 0.359591181384888 0.736280308987186 GO:0043138 3'-5' DNA helicase activity 18/6355 48/18639 0.375 1.09986231313926 0.359591181384888 0.736280308987186 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 13/6355 34/18639 0.382352941176471 1.12142824084787 0.364981532868427 0.746208534558891 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 8/6355 20/18639 0.4 1.17318646734854 0.365822457911622 0.746213767755458 GO:0005021 vascular endothelial growth factor receptor activity 19/6355 51/18639 0.372549019607843 1.09267367056972 0.366067131351734 0.746213767755458 GO:0051087 protein-folding chaperone binding 48/6355 134/18639 0.358208955223881 1.05061474687929 0.366990761015284 0.746991534237904 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 20/6355 54/18639 0.37037037037037 1.08628376606347 0.372107954413365 0.756290208232473 GO:0042805 actinin binding 14/6355 37/18639 0.378378378378378 1.109770982627 0.373243396588665 0.757480707657115 GO:0045296 cadherin binding 117/6355 334/18639 0.350299401197605 1.02741629251332 0.377994168271198 0.762954936251793 GO:0004022 alcohol dehydrogenase (NAD+) activity 9/6355 23/18639 0.391304347826087 1.14768241371053 0.378155458243813 0.762954936251793 GO:0008171 O-methyltransferase activity 9/6355 23/18639 0.391304347826087 1.14768241371053 0.378155458243813 0.762954936251793 GO:0017134 fibroblast growth factor binding 9/6355 23/18639 0.391304347826087 1.14768241371053 0.378155458243813 0.762954936251793 GO:0048306 calcium-dependent protein binding 29/6355 80/18639 0.3625 1.06320023603462 0.381926425086653 0.769436569838316 GO:0005245 voltage-gated calcium channel activity 16/6355 43/18639 0.372093023255814 1.09133624869632 0.387579381381093 0.774005851012583 GO:0005507 copper ion binding 23/6355 63/18639 0.365079365079365 1.07076542654827 0.388097684660653 0.774005851012583 GO:0000340 RNA 7-methylguanosine cap binding 5/6355 12/18639 0.416666666666667 1.2220692368214 0.390373052578915 0.774005851012583 GO:0005078 MAP-kinase scaffold activity 5/6355 12/18639 0.416666666666667 1.2220692368214 0.390373052578915 0.774005851012583 GO:0005095 GTPase inhibitor activity 5/6355 12/18639 0.416666666666667 1.2220692368214 0.390373052578915 0.774005851012583 GO:0005247 voltage-gated chloride channel activity 5/6355 12/18639 0.416666666666667 1.2220692368214 0.390373052578915 0.774005851012583 GO:0035197 siRNA binding 5/6355 12/18639 0.416666666666667 1.2220692368214 0.390373052578915 0.774005851012583 GO:0045295 gamma-catenin binding 5/6355 12/18639 0.416666666666667 1.2220692368214 0.390373052578915 0.774005851012583 GO:0070410 co-SMAD binding 5/6355 12/18639 0.416666666666667 1.2220692368214 0.390373052578915 0.774005851012583 GO:0070679 inositol 1,4,5 trisphosphate binding 5/6355 12/18639 0.416666666666667 1.2220692368214 0.390373052578915 0.774005851012583 GO:0097677 STAT family protein binding 5/6355 12/18639 0.416666666666667 1.2220692368214 0.390373052578915 0.774005851012583 GO:0008235 metalloexopeptidase activity 24/6355 66/18639 0.363636363636364 1.06653315213504 0.392840430710547 0.777778898734388 GO:0003785 actin monomer binding 11/6355 29/18639 0.379310344827586 1.11250440869259 0.397744897264678 0.785232762794737 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 11/6355 29/18639 0.379310344827586 1.11250440869259 0.397744897264678 0.785232762794737 GO:0016763 pentosyltransferase activity 18/6355 49/18639 0.36734693877551 1.07741614348336 0.399699157523961 0.787308292350099 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 19/6355 52/18639 0.365384615384615 1.07166071536646 0.405114847069998 0.787308292350099 GO:0051059 NF-kappaB binding 12/6355 32/18639 0.375 1.09986231313926 0.40576052518112 0.787308292350099 GO:0071813 lipoprotein particle binding 12/6355 32/18639 0.375 1.09986231313926 0.40576052518112 0.787308292350099 GO:0071814 protein-lipid complex binding 12/6355 32/18639 0.375 1.09986231313926 0.40576052518112 0.787308292350099 GO:0000774 adenyl-nucleotide exchange factor activity 6/6355 15/18639 0.4 1.17318646734854 0.406223654470915 0.787308292350099 GO:0004467 long-chain fatty acid-CoA ligase activity 6/6355 15/18639 0.4 1.17318646734854 0.406223654470915 0.787308292350099 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 6/6355 15/18639 0.4 1.17318646734854 0.406223654470915 0.787308292350099 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 6/6355 15/18639 0.4 1.17318646734854 0.406223654470915 0.787308292350099 GO:0005402 carbohydrate:monoatomic cation symporter activity 6/6355 15/18639 0.4 1.17318646734854 0.406223654470915 0.787308292350099 GO:0033130 acetylcholine receptor binding 6/6355 15/18639 0.4 1.17318646734854 0.406223654470915 0.787308292350099 GO:0045504 dynein heavy chain binding 6/6355 15/18639 0.4 1.17318646734854 0.406223654470915 0.787308292350099 GO:0050700 CARD domain binding 6/6355 15/18639 0.4 1.17318646734854 0.406223654470915 0.787308292350099 GO:1901681 sulfur compound binding 96/6355 275/18639 0.349090909090909 1.02387182604964 0.409440123379079 0.792427654517375 GO:0044325 transmembrane transporter binding 48/6355 136/18639 0.352941176470588 1.03516453001342 0.41517762329906 0.80240499986831 GO:0008525 phosphatidylcholine transporter activity 7/6355 18/18639 0.388888888888889 1.14059795436664 0.418518523333078 0.805472800492991 GO:0032393 MHC class I receptor activity 7/6355 18/18639 0.388888888888889 1.14059795436664 0.418518523333078 0.805472800492991 GO:0035615 clathrin adaptor activity 7/6355 18/18639 0.388888888888889 1.14059795436664 0.418518523333078 0.805472800492991 GO:0016877 ligase activity, forming carbon-sulfur bonds 15/6355 41/18639 0.365853658536585 1.07303640306269 0.425228507002153 0.816696003148895 GO:0005123 death receptor binding 8/6355 21/18639 0.380952380952381 1.11732044509385 0.428498701216728 0.816696003148895 GO:0009931 calcium-dependent protein serine/threonine kinase activity 8/6355 21/18639 0.380952380952381 1.11732044509385 0.428498701216728 0.816696003148895 GO:0009975 cyclase activity 8/6355 21/18639 0.380952380952381 1.11732044509385 0.428498701216728 0.816696003148895 GO:0015174 basic amino acid transmembrane transporter activity 8/6355 21/18639 0.380952380952381 1.11732044509385 0.428498701216728 0.816696003148895 GO:0072542 protein phosphatase activator activity 8/6355 21/18639 0.380952380952381 1.11732044509385 0.428498701216728 0.816696003148895 GO:0140312 cargo adaptor activity 8/6355 21/18639 0.380952380952381 1.11732044509385 0.428498701216728 0.816696003148895 GO:0140359 ABC-type transporter activity 17/6355 47/18639 0.361702127659574 1.06086010345347 0.435571606717691 0.828065278052701 GO:0004806 triacylglycerol lipase activity 9/6355 24/18639 0.375 1.09986231313926 0.436867530583682 0.828065278052701 GO:0043998 histone H2A acetyltransferase activity 9/6355 24/18639 0.375 1.09986231313926 0.436867530583682 0.828065278052701 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 9/6355 24/18639 0.375 1.09986231313926 0.436867530583682 0.828065278052701 GO:0005006 epidermal growth factor receptor activity 18/6355 50/18639 0.36 1.05586782061369 0.44017910062168 0.82977674508437 GO:0005017 platelet-derived growth factor receptor activity 18/6355 50/18639 0.36 1.05586782061369 0.44017910062168 0.82977674508437 GO:0005019 platelet-derived growth factor beta-receptor activity 18/6355 50/18639 0.36 1.05586782061369 0.44017910062168 0.82977674508437 GO:0032813 tumor necrosis factor receptor superfamily binding 18/6355 50/18639 0.36 1.05586782061369 0.44017910062168 0.82977674508437 GO:0016251 RNA polymerase II general transcription initiation factor activity 19/6355 53/18639 0.358490566037736 1.05144070186898 0.44447731323666 0.835593093642726 GO:0038064 collagen receptor activity 19/6355 53/18639 0.358490566037736 1.05144070186898 0.44447731323666 0.835593093642726 GO:0008106 alcohol dehydrogenase (NADP+) activity 11/6355 30/18639 0.366666666666667 1.07542092840283 0.450354131698364 0.842388256737806 GO:0035925 mRNA 3'-UTR AU-rich region binding 11/6355 30/18639 0.366666666666667 1.07542092840283 0.450354131698364 0.842388256737806 GO:0000182 rDNA binding 4/6355 10/18639 0.4 1.17318646734854 0.461540735730801 0.842388256737806 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 4/6355 10/18639 0.4 1.17318646734854 0.461540735730801 0.842388256737806 GO:0008190 eukaryotic initiation factor 4E binding 4/6355 10/18639 0.4 1.17318646734854 0.461540735730801 0.842388256737806 GO:0015658 branched-chain amino acid transmembrane transporter activity 4/6355 10/18639 0.4 1.17318646734854 0.461540735730801 0.842388256737806 GO:0015924 mannosyl-oligosaccharide mannosidase activity 4/6355 10/18639 0.4 1.17318646734854 0.461540735730801 0.842388256737806 GO:0016175 superoxide-generating NAD(P)H oxidase activity 4/6355 10/18639 0.4 1.17318646734854 0.461540735730801 0.842388256737806 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 4/6355 10/18639 0.4 1.17318646734854 0.461540735730801 0.842388256737806 GO:0030957 Tat protein binding 4/6355 10/18639 0.4 1.17318646734854 0.461540735730801 0.842388256737806 GO:0031434 mitogen-activated protein kinase kinase binding 4/6355 10/18639 0.4 1.17318646734854 0.461540735730801 0.842388256737806 GO:0031957 very long-chain fatty acid-CoA ligase activity 4/6355 10/18639 0.4 1.17318646734854 0.461540735730801 0.842388256737806 GO:0035256 G protein-coupled glutamate receptor binding 4/6355 10/18639 0.4 1.17318646734854 0.461540735730801 0.842388256737806 GO:0035374 chondroitin sulfate binding 4/6355 10/18639 0.4 1.17318646734854 0.461540735730801 0.842388256737806 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 4/6355 10/18639 0.4 1.17318646734854 0.461540735730801 0.842388256737806 GO:0050308 sugar-phosphatase activity 4/6355 10/18639 0.4 1.17318646734854 0.461540735730801 0.842388256737806 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 4/6355 10/18639 0.4 1.17318646734854 0.461540735730801 0.842388256737806 GO:0070739 protein-glutamic acid ligase activity 4/6355 10/18639 0.4 1.17318646734854 0.461540735730801 0.842388256737806 GO:0070740 tubulin-glutamic acid ligase activity 4/6355 10/18639 0.4 1.17318646734854 0.461540735730801 0.842388256737806 GO:0071723 lipopeptide binding 4/6355 10/18639 0.4 1.17318646734854 0.461540735730801 0.842388256737806 GO:1905394 retromer complex binding 4/6355 10/18639 0.4 1.17318646734854 0.461540735730801 0.842388256737806 GO:1990757 ubiquitin ligase activator activity 4/6355 10/18639 0.4 1.17318646734854 0.461540735730801 0.842388256737806 GO:0003684 damaged DNA binding 26/6355 74/18639 0.351351351351351 1.03050162672507 0.468473941000499 0.845028017801751 GO:0008307 structural constituent of muscle 15/6355 42/18639 0.357142857142857 1.04748791727549 0.469760632043488 0.845028017801751 GO:0042056 chemoattractant activity 15/6355 42/18639 0.357142857142857 1.04748791727549 0.469760632043488 0.845028017801751 GO:0005035 death receptor activity 5/6355 13/18639 0.384615384615385 1.12806391091206 0.471572239252211 0.845028017801751 GO:0008253 5'-nucleotidase activity 5/6355 13/18639 0.384615384615385 1.12806391091206 0.471572239252211 0.845028017801751 GO:0008417 fucosyltransferase activity 5/6355 13/18639 0.384615384615385 1.12806391091206 0.471572239252211 0.845028017801751 GO:0009982 pseudouridine synthase activity 5/6355 13/18639 0.384615384615385 1.12806391091206 0.471572239252211 0.845028017801751 GO:0019104 DNA N-glycosylase activity 5/6355 13/18639 0.384615384615385 1.12806391091206 0.471572239252211 0.845028017801751 GO:0019855 calcium channel inhibitor activity 5/6355 13/18639 0.384615384615385 1.12806391091206 0.471572239252211 0.845028017801751 GO:0032396 inhibitory MHC class I receptor activity 5/6355 13/18639 0.384615384615385 1.12806391091206 0.471572239252211 0.845028017801751 GO:0043560 insulin receptor substrate binding 5/6355 13/18639 0.384615384615385 1.12806391091206 0.471572239252211 0.845028017801751 GO:0070700 BMP receptor binding 5/6355 13/18639 0.384615384615385 1.12806391091206 0.471572239252211 0.845028017801751 GO:0071714 icosanoid transmembrane transporter activity 5/6355 13/18639 0.384615384615385 1.12806391091206 0.471572239252211 0.845028017801751 GO:0097157 pre-mRNA intronic binding 5/6355 13/18639 0.384615384615385 1.12806391091206 0.471572239252211 0.845028017801751 GO:0141110 transporter inhibitor activity 16/6355 45/18639 0.355555555555556 1.04283241542093 0.473636442483412 0.84710655505766 GO:0000049 tRNA binding 28/6355 80/18639 0.35 1.02653815892998 0.473961650181028 0.84710655505766 GO:0016879 ligase activity, forming carbon-nitrogen bonds 17/6355 48/18639 0.354166666666667 1.03875885129819 0.477238291577614 0.847638644216023 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 6/6355 16/18639 0.375 1.09986231313926 0.479180336606881 0.847638644216023 GO:0008296 3'-5'-DNA exonuclease activity 6/6355 16/18639 0.375 1.09986231313926 0.479180336606881 0.847638644216023 GO:0015562 efflux transmembrane transporter activity 6/6355 16/18639 0.375 1.09986231313926 0.479180336606881 0.847638644216023 GO:0017070 U6 snRNA binding 6/6355 16/18639 0.375 1.09986231313926 0.479180336606881 0.847638644216023 GO:0022841 potassium ion leak channel activity 6/6355 16/18639 0.375 1.09986231313926 0.479180336606881 0.847638644216023 GO:0030275 LRR domain binding 6/6355 16/18639 0.375 1.09986231313926 0.479180336606881 0.847638644216023 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 6/6355 16/18639 0.375 1.09986231313926 0.479180336606881 0.847638644216023 GO:0005010 insulin-like growth factor receptor activity 18/6355 51/18639 0.352941176470588 1.03516453001342 0.480603811132559 0.847979579693554 GO:0030544 Hsp70 protein binding 18/6355 51/18639 0.352941176470588 1.03516453001342 0.480603811132559 0.847979579693554 GO:0003756 protein disulfide isomerase activity 7/6355 19/18639 0.368421052631579 1.08056648308419 0.485313609953769 0.850842435771366 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 7/6355 19/18639 0.368421052631579 1.08056648308419 0.485313609953769 0.850842435771366 GO:0022840 leak channel activity 7/6355 19/18639 0.368421052631579 1.08056648308419 0.485313609953769 0.850842435771366 GO:0022842 narrow pore channel activity 7/6355 19/18639 0.368421052631579 1.08056648308419 0.485313609953769 0.850842435771366 GO:0120227 acyl-CoA binding 7/6355 19/18639 0.368421052631579 1.08056648308419 0.485313609953769 0.850842435771366 GO:0008276 protein methyltransferase activity 33/6355 95/18639 0.347368421052632 1.01881982690795 0.48596229404996 0.850897129861302 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 21/6355 60/18639 0.35 1.02653815892998 0.489561726021309 0.856111749311376 GO:0061133 endopeptidase activator activity 8/6355 22/18639 0.363636363636364 1.06653315213504 0.490462944013775 0.856600680419495 GO:0015645 fatty acid ligase activity 9/6355 25/18639 0.36 1.05586782061369 0.494912527806715 0.862186426444567 GO:0120515 fatty acid-CoA ligase activity 9/6355 25/18639 0.36 1.05586782061369 0.494912527806715 0.862186426444567 GO:0051393 alpha-actinin binding 10/6355 28/18639 0.357142857142857 1.04748791727549 0.49884051533705 0.866837616815201 GO:0051959 dynein light intermediate chain binding 10/6355 28/18639 0.357142857142857 1.04748791727549 0.49884051533705 0.866837616815201 GO:0005164 tumor necrosis factor receptor binding 11/6355 31/18639 0.354838709677419 1.04072993071242 0.502365437544659 0.871863441985567 GO:0051427 hormone receptor binding 12/6355 34/18639 0.352941176470588 1.03516453001342 0.505569888991719 0.876321140918979 GO:0004180 carboxypeptidase activity 16/6355 46/18639 0.347826086956522 1.02016214552047 0.516175894099038 0.885251373131481 GO:0030276 clathrin binding 16/6355 46/18639 0.347826086956522 1.02016214552047 0.516175894099038 0.885251373131481 GO:0005004 GPI-linked ephrin receptor activity 17/6355 49/18639 0.346938775510204 1.01755969106762 0.518430956543618 0.885251373131481 GO:0005008 hepatocyte growth factor receptor activity 17/6355 49/18639 0.346938775510204 1.01755969106762 0.518430956543618 0.885251373131481 GO:0005009 insulin receptor activity 17/6355 49/18639 0.346938775510204 1.01755969106762 0.518430956543618 0.885251373131481 GO:0005011 macrophage colony-stimulating factor receptor activity 17/6355 49/18639 0.346938775510204 1.01755969106762 0.518430956543618 0.885251373131481 GO:0005018 platelet-derived growth factor alpha-receptor activity 17/6355 49/18639 0.346938775510204 1.01755969106762 0.518430956543618 0.885251373131481 GO:0005020 stem cell factor receptor activity 17/6355 49/18639 0.346938775510204 1.01755969106762 0.518430956543618 0.885251373131481 GO:0008288 boss receptor activity 17/6355 49/18639 0.346938775510204 1.01755969106762 0.518430956543618 0.885251373131481 GO:0036332 placental growth factor receptor activity 17/6355 49/18639 0.346938775510204 1.01755969106762 0.518430956543618 0.885251373131481 GO:0038062 protein tyrosine kinase collagen receptor activity 17/6355 49/18639 0.346938775510204 1.01755969106762 0.518430956543618 0.885251373131481 GO:0060175 brain-derived neurotrophic factor receptor activity 17/6355 49/18639 0.346938775510204 1.01755969106762 0.518430956543618 0.885251373131481 GO:0061980 regulatory RNA binding 20/6355 58/18639 0.344827586206897 1.01136764426599 0.524544912731238 0.894582784336195 GO:0051536 iron-sulfur cluster binding 26/6355 76/18639 0.342105263157895 1.00338316286389 0.53472324009923 0.900606312665517 GO:0072341 modified amino acid binding 31/6355 91/18639 0.340659340659341 0.999142321093541 0.541841971273675 0.900606312665517 GO:0008494 translation activator activity 5/6355 14/18639 0.357142857142857 1.04748791727549 0.54887407421897 0.900606312665517 GO:0030983 mismatched DNA binding 5/6355 14/18639 0.357142857142857 1.04748791727549 0.54887407421897 0.900606312665517 GO:0004659 prenyltransferase activity 6/6355 17/18639 0.352941176470588 1.03516453001342 0.549120855245073 0.900606312665517 GO:0005092 GDP-dissociation inhibitor activity 6/6355 17/18639 0.352941176470588 1.03516453001342 0.549120855245073 0.900606312665517 GO:0016018 cyclosporin A binding 6/6355 17/18639 0.352941176470588 1.03516453001342 0.549120855245073 0.900606312665517 GO:0017110 nucleoside diphosphate phosphatase activity 6/6355 17/18639 0.352941176470588 1.03516453001342 0.549120855245073 0.900606312665517 GO:0036041 long-chain fatty acid binding 6/6355 17/18639 0.352941176470588 1.03516453001342 0.549120855245073 0.900606312665517 GO:0038191 neuropilin binding 6/6355 17/18639 0.352941176470588 1.03516453001342 0.549120855245073 0.900606312665517 GO:0045125 bioactive lipid receptor activity 6/6355 17/18639 0.352941176470588 1.03516453001342 0.549120855245073 0.900606312665517 GO:0070492 oligosaccharide binding 6/6355 17/18639 0.352941176470588 1.03516453001342 0.549120855245073 0.900606312665517 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 4/6355 11/18639 0.363636363636364 1.06653315213504 0.549140412067025 0.900606312665517 GO:0004954 prostanoid receptor activity 4/6355 11/18639 0.363636363636364 1.06653315213504 0.549140412067025 0.900606312665517 GO:0008172 S-methyltransferase activity 4/6355 11/18639 0.363636363636364 1.06653315213504 0.549140412067025 0.900606312665517 GO:0010854 adenylate cyclase regulator activity 4/6355 11/18639 0.363636363636364 1.06653315213504 0.549140412067025 0.900606312665517 GO:0015173 aromatic amino acid transmembrane transporter activity 4/6355 11/18639 0.363636363636364 1.06653315213504 0.549140412067025 0.900606312665517 GO:0015217 ADP transmembrane transporter activity 4/6355 11/18639 0.363636363636364 1.06653315213504 0.549140412067025 0.900606312665517 GO:0016176 superoxide-generating NADPH oxidase activator activity 4/6355 11/18639 0.363636363636364 1.06653315213504 0.549140412067025 0.900606312665517 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 4/6355 11/18639 0.363636363636364 1.06653315213504 0.549140412067025 0.900606312665517 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 4/6355 11/18639 0.363636363636364 1.06653315213504 0.549140412067025 0.900606312665517 GO:0032050 clathrin heavy chain binding 4/6355 11/18639 0.363636363636364 1.06653315213504 0.549140412067025 0.900606312665517 GO:0032404 mismatch repair complex binding 4/6355 11/18639 0.363636363636364 1.06653315213504 0.549140412067025 0.900606312665517 GO:0034056 estrogen response element binding 4/6355 11/18639 0.363636363636364 1.06653315213504 0.549140412067025 0.900606312665517 GO:0043522 leucine zipper domain binding 4/6355 11/18639 0.363636363636364 1.06653315213504 0.549140412067025 0.900606312665517 GO:0050786 RAGE receptor binding 4/6355 11/18639 0.363636363636364 1.06653315213504 0.549140412067025 0.900606312665517 GO:0070697 activin receptor binding 4/6355 11/18639 0.363636363636364 1.06653315213504 0.549140412067025 0.900606312665517 GO:0000339 RNA cap binding 7/6355 20/18639 0.35 1.02653815892998 0.549654999514924 0.900606312665517 GO:0001614 purinergic nucleotide receptor activity 7/6355 20/18639 0.35 1.02653815892998 0.549654999514924 0.900606312665517 GO:0016502 nucleotide receptor activity 7/6355 20/18639 0.35 1.02653815892998 0.549654999514924 0.900606312665517 GO:0042288 MHC class I protein binding 7/6355 20/18639 0.35 1.02653815892998 0.549654999514924 0.900606312665517 GO:0003887 DNA-directed DNA polymerase activity 8/6355 23/18639 0.347826086956522 1.02016214552047 0.550360269757754 0.900606312665517 GO:0120014 phospholipid transfer activity 9/6355 26/18639 0.346153846153846 1.01525751982086 0.551171259843651 0.900606312665517 GO:0016853 isomerase activity 61/6355 180/18639 0.338888888888889 0.993949645948072 0.551525846548999 0.900606312665517 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 11/6355 32/18639 0.34375 1.00820712037766 0.552968010687465 0.900606312665517 GO:0042910 xenobiotic transmembrane transporter activity 11/6355 32/18639 0.34375 1.00820712037766 0.552968010687465 0.900606312665517 GO:0003697 single-stranded DNA binding 41/6355 121/18639 0.338842975206612 0.993814982671288 0.553807406477125 0.900606312665517 GO:0051082 unfolded protein binding 41/6355 121/18639 0.338842975206612 0.993814982671288 0.553807406477125 0.900606312665517 GO:0016229 steroid dehydrogenase activity 12/6355 35/18639 0.342857142857143 1.00558840058447 0.553912978328166 0.900606312665517 GO:0042887 amide transmembrane transporter activity 13/6355 38/18639 0.342105263157895 1.00338316286389 0.554872829791744 0.900606312665517 GO:0043531 ADP binding 13/6355 38/18639 0.342105263157895 1.00338316286389 0.554872829791744 0.900606312665517 GO:0016248 channel inhibitor activity 15/6355 44/18639 0.340909090909091 0.9998748301266 0.556809792992448 0.902686934992462 GO:0005007 fibroblast growth factor receptor activity 17/6355 50/18639 0.34 0.997208497246263 0.558742518685222 0.904183175372279 GO:0005003 ephrin receptor activity 18/6355 53/18639 0.339622641509434 0.996101717560085 0.559701196366149 0.904183175372279 GO:0005005 transmembrane-ephrin receptor activity 18/6355 53/18639 0.339622641509434 0.996101717560085 0.559701196366149 0.904183175372279 GO:0170055 lipid transmembrane transporter activity 19/6355 56/18639 0.339285714285714 0.995113521411712 0.560652843055446 0.90465997392319 GO:0015179 L-amino acid transmembrane transporter activity 21/6355 62/18639 0.338709677419355 0.993424024770945 0.562531692858542 0.906630026618796 GO:0005548 phospholipid transporter activity 23/6355 68/18639 0.338235294117647 0.992032674596196 0.564374787566447 0.907918203037876 GO:0004175 endopeptidase activity 137/6355 405/18639 0.338271604938272 0.992139173004633 0.564648693761582 0.907918203037876 GO:0051540 metal cluster binding 26/6355 77/18639 0.337662337662338 0.990352212696823 0.567069176541175 0.910747465354008 GO:0001664 G protein-coupled receptor binding 100/6355 297/18639 0.336700336700337 0.987530696421334 0.583712020609836 0.935986340002378 GO:0061134 peptidase regulator activity 76/6355 226/18639 0.336283185840708 0.986307207062936 0.584142418288857 0.935986340002378 GO:0141108 transporter regulator activity 57/6355 170/18639 0.335294117647059 0.98340630351275 0.590747479866659 0.945470414931772 GO:0017069 snRNA binding 18/6355 54/18639 0.333333333333333 0.97765538945712 0.597670026250285 0.952352323990775 GO:0050661 NADP binding 18/6355 54/18639 0.333333333333333 0.97765538945712 0.597670026250285 0.952352323990775 GO:0005030 neurotrophin receptor activity 17/6355 51/18639 0.333333333333333 0.97765538945712 0.597811872461554 0.952352323990775 GO:0005048 signal sequence binding 17/6355 51/18639 0.333333333333333 0.97765538945712 0.597811872461554 0.952352323990775 GO:0055106 ubiquitin-protein transferase regulator activity 12/6355 36/18639 0.333333333333333 0.97765538945712 0.600376354578783 0.954879037815161 GO:0019239 deaminase activity 11/6355 33/18639 0.333333333333333 0.97765538945712 0.601476781439449 0.954879037815161 GO:0030296 protein tyrosine kinase activator activity 11/6355 33/18639 0.333333333333333 0.97765538945712 0.601476781439449 0.954879037815161 GO:0033612 receptor serine/threonine kinase binding 10/6355 30/18639 0.333333333333333 0.97765538945712 0.602896037213527 0.956030770172889 GO:0004683 calcium/calmodulin-dependent protein kinase activity 9/6355 27/18639 0.333333333333333 0.97765538945712 0.60472783175374 0.956733584565618 GO:0016405 CoA-ligase activity 9/6355 27/18639 0.333333333333333 0.97765538945712 0.60472783175374 0.956733584565618 GO:0015295 solute:proton symporter activity 8/6355 24/18639 0.333333333333333 0.97765538945712 0.60710663934479 0.957746331274513 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 8/6355 24/18639 0.333333333333333 0.97765538945712 0.60710663934479 0.957746331274513 GO:0015085 calcium ion transmembrane transporter activity 49/6355 147/18639 0.333333333333333 0.97765538945712 0.608107263410951 0.957746331274513 GO:0019200 carbohydrate kinase activity 7/6355 21/18639 0.333333333333333 0.97765538945712 0.610233148664022 0.957746331274513 GO:0035613 RNA stem-loop binding 7/6355 21/18639 0.333333333333333 0.97765538945712 0.610233148664022 0.957746331274513 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 7/6355 21/18639 0.333333333333333 0.97765538945712 0.610233148664022 0.957746331274513 GO:0061891 calcium ion sensor activity 7/6355 21/18639 0.333333333333333 0.97765538945712 0.610233148664022 0.957746331274513 GO:0008308 voltage-gated monoatomic anion channel activity 6/6355 18/18639 0.333333333333333 0.97765538945712 0.614422021201071 0.959704588336599 GO:0016854 racemase and epimerase activity 6/6355 18/18639 0.333333333333333 0.97765538945712 0.614422021201071 0.959704588336599 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 6/6355 18/18639 0.333333333333333 0.97765538945712 0.614422021201071 0.959704588336599 GO:0050811 GABA receptor binding 6/6355 18/18639 0.333333333333333 0.97765538945712 0.614422021201071 0.959704588336599 GO:0008242 omega peptidase activity 5/6355 15/18639 0.333333333333333 0.97765538945712 0.620199284092999 0.959704588336599 GO:0008252 nucleotidase activity 5/6355 15/18639 0.333333333333333 0.97765538945712 0.620199284092999 0.959704588336599 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 5/6355 15/18639 0.333333333333333 0.97765538945712 0.620199284092999 0.959704588336599 GO:0017081 chloride channel regulator activity 5/6355 15/18639 0.333333333333333 0.97765538945712 0.620199284092999 0.959704588336599 GO:0140776 protein-containing complex destabilizing activity 5/6355 15/18639 0.333333333333333 0.97765538945712 0.620199284092999 0.959704588336599 GO:0003995 acyl-CoA dehydrogenase activity 4/6355 12/18639 0.333333333333333 0.97765538945712 0.628524091811079 0.959704588336599 GO:0004000 adenosine deaminase activity 4/6355 12/18639 0.333333333333333 0.97765538945712 0.628524091811079 0.959704588336599 GO:0004526 ribonuclease P activity 4/6355 12/18639 0.333333333333333 0.97765538945712 0.628524091811079 0.959704588336599 GO:0005049 nuclear export signal receptor activity 4/6355 12/18639 0.333333333333333 0.97765538945712 0.628524091811079 0.959704588336599 GO:0008179 adenylate cyclase binding 4/6355 12/18639 0.333333333333333 0.97765538945712 0.628524091811079 0.959704588336599 GO:0015132 prostaglandin transmembrane transporter activity 4/6355 12/18639 0.333333333333333 0.97765538945712 0.628524091811079 0.959704588336599 GO:0016208 AMP binding 4/6355 12/18639 0.333333333333333 0.97765538945712 0.628524091811079 0.959704588336599 GO:0016273 arginine N-methyltransferase activity 4/6355 12/18639 0.333333333333333 0.97765538945712 0.628524091811079 0.959704588336599 GO:0016274 protein-arginine N-methyltransferase activity 4/6355 12/18639 0.333333333333333 0.97765538945712 0.628524091811079 0.959704588336599 GO:0016801 hydrolase activity, acting on ether bonds 4/6355 12/18639 0.333333333333333 0.97765538945712 0.628524091811079 0.959704588336599 GO:0016803 ether hydrolase activity 4/6355 12/18639 0.333333333333333 0.97765538945712 0.628524091811079 0.959704588336599 GO:0017166 vinculin binding 4/6355 12/18639 0.333333333333333 0.97765538945712 0.628524091811079 0.959704588336599 GO:0031543 peptidyl-proline dioxygenase activity 4/6355 12/18639 0.333333333333333 0.97765538945712 0.628524091811079 0.959704588336599 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 4/6355 12/18639 0.333333333333333 0.97765538945712 0.628524091811079 0.959704588336599 GO:1990247 N6-methyladenosine-containing RNA reader activity 4/6355 12/18639 0.333333333333333 0.97765538945712 0.628524091811079 0.959704588336599 GO:0008194 UDP-glycosyltransferase activity 48/6355 145/18639 0.331034482758621 0.970912938495347 0.630247202955152 0.959704588336599 GO:0016782 transferase activity, transferring sulphur-containing groups 23/6355 70/18639 0.328571428571429 0.963688883893447 0.630436064592403 0.959704588336599 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 22/6355 67/18639 0.328358208955224 0.963063517972686 0.630979894926779 0.959704588336599 GO:0005506 iron ion binding 51/6355 154/18639 0.331168831168831 0.971306977837269 0.630981391170507 0.959704588336599 GO:0060590 ATPase regulator activity 16/6355 49/18639 0.326530612244898 0.957703238651873 0.636650224600476 0.967259106394108 GO:0008200 ion channel inhibitor activity 14/6355 43/18639 0.325581395348837 0.95491921760928 0.6399595929621 0.971216210464509 GO:0004532 RNA exonuclease activity 13/6355 40/18639 0.325 0.953214004720692 0.642035544927077 0.972225253746716 GO:0071949 FAD binding 13/6355 40/18639 0.325 0.953214004720692 0.642035544927077 0.972225253746716 GO:0090482 vitamin transmembrane transporter activity 11/6355 34/18639 0.323529411764706 0.94890081917897 0.647345295218797 0.979189700122396 GO:0016878 acid-thiol ligase activity 10/6355 31/18639 0.32258064516129 0.946118118829471 0.65076775134156 0.983287238320909 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 40/6355 122/18639 0.327868852459016 0.961628251925036 0.652821180279978 0.985187232198128 GO:0016866 intramolecular transferase activity 9/6355 28/18639 0.321428571428571 0.942739125547938 0.65488498163533 0.985187232198128 GO:0046625 sphingolipid binding 9/6355 28/18639 0.321428571428571 0.942739125547938 0.65488498163533 0.985187232198128 GO:0050698 proteoglycan sulfotransferase activity 9/6355 28/18639 0.321428571428571 0.942739125547938 0.65488498163533 0.985187232198128 GO:0050660 flavin adenine dinucleotide binding 28/6355 86/18639 0.325581395348837 0.95491921760928 0.657274802383995 0.987689486430212 GO:0030165 PDZ domain binding 27/6355 83/18639 0.325301204819277 0.954097428265383 0.65798182042303 0.987689486430212 GO:0015296 monoatomic anion:monoatomic cation symporter activity 8/6355 25/18639 0.32 0.938549173878836 0.659903868303884 0.988377667579101 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 8/6355 25/18639 0.32 0.938549173878836 0.659903868303884 0.988377667579101 GO:0048029 monosaccharide binding 24/6355 74/18639 0.324324324324324 0.951232270823144 0.660592040522752 0.988377667579101 GO:0140299 molecular sensor activity 23/6355 71/18639 0.323943661971831 0.950115801021709 0.66165555688786 0.988895181552572 GO:0015377 chloride:monoatomic cation symporter activity 7/6355 22/18639 0.318181818181818 0.93321650811816 0.666125910834138 0.993421542347881 GO:0140784 metal ion sensor activity 7/6355 22/18639 0.318181818181818 0.93321650811816 0.666125910834138 0.993421542347881 GO:0016247 channel regulator activity 55/6355 168/18639 0.327380952380952 0.960197257502529 0.67275201258797 1 GO:0050145 nucleoside monophosphate kinase activity 6/6355 19/18639 0.315789473684211 0.926199842643588 0.674010518699826 1 GO:0070003 threonine-type peptidase activity 6/6355 19/18639 0.315789473684211 0.926199842643588 0.674010518699826 1 GO:0030020 extracellular matrix structural constituent conferring tensile strength 14/6355 44/18639 0.318181818181818 0.93321650811816 0.678762832947937 1 GO:0017080 sodium channel regulator activity 13/6355 41/18639 0.317073170731707 0.929964882654334 0.682054832992962 1 GO:0005149 interleukin-1 receptor binding 5/6355 16/18639 0.3125 0.91655192761605 0.684298805677598 1 GO:0015385 sodium:proton antiporter activity 5/6355 16/18639 0.3125 0.91655192761605 0.684298805677598 1 GO:0031435 mitogen-activated protein kinase kinase kinase binding 5/6355 16/18639 0.3125 0.91655192761605 0.684298805677598 1 GO:0055102 lipase inhibitor activity 5/6355 16/18639 0.3125 0.91655192761605 0.684298805677598 1 GO:0000146 microfilament motor activity 12/6355 38/18639 0.315789473684211 0.926199842643588 0.685823242771255 1 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 12/6355 38/18639 0.315789473684211 0.926199842643588 0.685823242771255 1 GO:0000175 3'-5'-RNA exonuclease activity 11/6355 35/18639 0.314285714285714 0.921789367202428 0.690168440460337 1 GO:0034061 DNA polymerase activity 11/6355 35/18639 0.314285714285714 0.921789367202428 0.690168440460337 1 GO:0008378 galactosyltransferase activity 10/6355 32/18639 0.3125 0.91655192761605 0.695222178911603 1 GO:0043425 bHLH transcription factor binding 10/6355 32/18639 0.3125 0.91655192761605 0.695222178911603 1 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 4/6355 13/18639 0.307692307692308 0.90245112872965 0.698280470726132 1 GO:0031432 titin binding 4/6355 13/18639 0.307692307692308 0.90245112872965 0.698280470726132 1 GO:0045159 myosin II binding 4/6355 13/18639 0.307692307692308 0.90245112872965 0.698280470726132 1 GO:1901338 catecholamine binding 4/6355 13/18639 0.307692307692308 0.90245112872965 0.698280470726132 1 GO:0035250 UDP-galactosyltransferase activity 9/6355 29/18639 0.310344827586207 0.910230879839388 0.701161292452416 1 GO:0099604 ligand-gated calcium channel activity 9/6355 29/18639 0.310344827586207 0.910230879839388 0.701161292452416 1 GO:0003743 translation initiation factor activity 16/6355 51/18639 0.313725490196078 0.920146248900819 0.7078273267773 1 GO:0008009 chemokine activity 14/6355 45/18639 0.311111111111111 0.912478363493312 0.715057320232247 1 GO:0140303 intramembrane lipid transporter activity 14/6355 45/18639 0.311111111111111 0.912478363493312 0.715057320232247 1 GO:0004602 glutathione peroxidase activity 7/6355 23/18639 0.304347826086957 0.892641877330414 0.716773378805055 1 GO:0005212 structural constituent of eye lens 7/6355 23/18639 0.304347826086957 0.892641877330414 0.716773378805055 1 GO:0031681 G-protein beta-subunit binding 7/6355 23/18639 0.304347826086957 0.892641877330414 0.716773378805055 1 GO:0140102 catalytic activity, acting on a rRNA 7/6355 23/18639 0.304347826086957 0.892641877330414 0.716773378805055 1 GO:0001094 TFIID-class transcription factor complex binding 3/6355 10/18639 0.3 0.879889850511408 0.718451058537399 1 GO:0003680 minor groove of adenine-thymine-rich DNA binding 3/6355 10/18639 0.3 0.879889850511408 0.718451058537399 1 GO:0004382 GDP phosphatase activity 3/6355 10/18639 0.3 0.879889850511408 0.718451058537399 1 GO:0004955 prostaglandin receptor activity 3/6355 10/18639 0.3 0.879889850511408 0.718451058537399 1 GO:0031956 medium-chain fatty acid-CoA ligase activity 3/6355 10/18639 0.3 0.879889850511408 0.718451058537399 1 GO:0031996 thioesterase binding 3/6355 10/18639 0.3 0.879889850511408 0.718451058537399 1 GO:0032356 oxidized DNA binding 3/6355 10/18639 0.3 0.879889850511408 0.718451058537399 1 GO:0033204 ribonuclease P RNA binding 3/6355 10/18639 0.3 0.879889850511408 0.718451058537399 1 GO:0043121 neurotrophin binding 3/6355 10/18639 0.3 0.879889850511408 0.718451058537399 1 GO:0047429 nucleoside triphosphate diphosphatase activity 3/6355 10/18639 0.3 0.879889850511408 0.718451058537399 1 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 3/6355 10/18639 0.3 0.879889850511408 0.718451058537399 1 GO:0141109 transporter activator activity 3/6355 10/18639 0.3 0.879889850511408 0.718451058537399 1 GO:1990763 arrestin family protein binding 3/6355 10/18639 0.3 0.879889850511408 0.718451058537399 1 GO:0005262 calcium channel activity 42/6355 131/18639 0.320610687022901 0.940340298256467 0.718606045541699 1 GO:0016500 protein-hormone receptor activity 21/6355 67/18639 0.313432835820896 0.919287903519382 0.724381211443967 1 GO:0010851 cyclase regulator activity 6/6355 20/18639 0.3 0.879889850511408 0.727305741207641 1 GO:0140939 histone H4 methyltransferase activity 6/6355 20/18639 0.3 0.879889850511408 0.727305741207641 1 GO:0004190 aspartic-type endopeptidase activity 11/6355 36/18639 0.305555555555556 0.896184107002361 0.729676958248221 1 GO:0017116 single-stranded DNA helicase activity 18/6355 58/18639 0.310344827586207 0.910230879839388 0.732933777821051 1 GO:0052689 carboxylic ester hydrolase activity 29/6355 92/18639 0.315217391304348 0.924521944377929 0.733975195700463 1 GO:0030246 carbohydrate binding 91/6355 280/18639 0.325 0.953214004720692 0.734615284712775 1 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 42/6355 132/18639 0.318181818181818 0.93321650811816 0.738942400623798 1 GO:0031489 myosin V binding 5/6355 17/18639 0.294117647058824 0.862637108344518 0.74062295169115 1 GO:0045236 CXCR chemokine receptor binding 5/6355 17/18639 0.294117647058824 0.862637108344518 0.74062295169115 1 GO:0061135 endopeptidase regulator activity 59/6355 184/18639 0.320652173913043 0.940461977901686 0.744464046656387 1 GO:0099106 ion channel regulator activity 51/6355 160/18639 0.31875 0.934882966168371 0.749788713567594 1 GO:0001671 ATPase activator activity 8/6355 27/18639 0.296296296296296 0.869027012850774 0.751809110089356 1 GO:0005104 fibroblast growth factor receptor binding 8/6355 27/18639 0.296296296296296 0.869027012850774 0.751809110089356 1 GO:0003777 microtubule motor activity 21/6355 68/18639 0.308823529411765 0.905768963761744 0.751880800784916 1 GO:0015386 potassium:proton antiporter activity 4/6355 14/18639 0.285714285714286 0.837990333820389 0.758043029328997 1 GO:0019763 immunoglobulin receptor activity 4/6355 14/18639 0.285714285714286 0.837990333820389 0.758043029328997 1 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 4/6355 14/18639 0.285714285714286 0.837990333820389 0.758043029328997 1 GO:0015144 carbohydrate transmembrane transporter activity 12/6355 40/18639 0.3 0.879889850511408 0.75938045092383 1 GO:0016298 lipase activity 41/6355 130/18639 0.315384615384615 0.925012406947891 0.759560320649908 1 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 41/6355 130/18639 0.315384615384615 0.925012406947891 0.759560320649908 1 GO:0004622 lysophospholipase activity 7/6355 24/18639 0.291666666666667 0.85544846577498 0.761930271523988 1 GO:0005315 phosphate transmembrane transporter activity 7/6355 24/18639 0.291666666666667 0.85544846577498 0.761930271523988 1 GO:0030552 cAMP binding 7/6355 24/18639 0.291666666666667 0.85544846577498 0.761930271523988 1 GO:0050699 WW domain binding 7/6355 24/18639 0.291666666666667 0.85544846577498 0.761930271523988 1 GO:0070300 phosphatidic acid binding 7/6355 24/18639 0.291666666666667 0.85544846577498 0.761930271523988 1 GO:0140612 DNA damage sensor activity 7/6355 24/18639 0.291666666666667 0.85544846577498 0.761930271523988 1 GO:0030551 cyclic nucleotide binding 11/6355 37/18639 0.297297297297297 0.871962914921216 0.765725852562661 1 GO:0070001 aspartic-type peptidase activity 11/6355 37/18639 0.297297297297297 0.871962914921216 0.765725852562661 1 GO:0004866 endopeptidase inhibitor activity 51/6355 161/18639 0.316770186335404 0.929076239670431 0.767115673209303 1 GO:0008376 acetylgalactosaminyltransferase activity 10/6355 34/18639 0.294117647058824 0.862637108344518 0.772912610777323 1 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 10/6355 34/18639 0.294117647058824 0.862637108344518 0.772912610777323 1 GO:0016831 carboxy-lyase activity 10/6355 34/18639 0.294117647058824 0.862637108344518 0.772912610777323 1 GO:0001846 opsonin binding 6/6355 21/18639 0.285714285714286 0.837990333820389 0.774134778225088 1 GO:0000099 sulfur amino acid transmembrane transporter activity 3/6355 11/18639 0.272727272727273 0.79989986410128 0.78194255096379 1 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 3/6355 11/18639 0.272727272727273 0.79989986410128 0.78194255096379 1 GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity 3/6355 11/18639 0.272727272727273 0.79989986410128 0.78194255096379 1 GO:0004523 RNA-DNA hybrid ribonuclease activity 3/6355 11/18639 0.272727272727273 0.79989986410128 0.78194255096379 1 GO:0005225 volume-sensitive anion channel activity 3/6355 11/18639 0.272727272727273 0.79989986410128 0.78194255096379 1 GO:0008046 axon guidance receptor activity 3/6355 11/18639 0.272727272727273 0.79989986410128 0.78194255096379 1 GO:0008199 ferric iron binding 3/6355 11/18639 0.272727272727273 0.79989986410128 0.78194255096379 1 GO:0008503 benzodiazepine receptor activity 3/6355 11/18639 0.272727272727273 0.79989986410128 0.78194255096379 1 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 3/6355 11/18639 0.272727272727273 0.79989986410128 0.78194255096379 1 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 3/6355 11/18639 0.272727272727273 0.79989986410128 0.78194255096379 1 GO:0048101 calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity 3/6355 11/18639 0.272727272727273 0.79989986410128 0.78194255096379 1 GO:0048407 platelet-derived growth factor binding 3/6355 11/18639 0.272727272727273 0.79989986410128 0.78194255096379 1 GO:0070990 snRNP binding 3/6355 11/18639 0.272727272727273 0.79989986410128 0.78194255096379 1 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 3/6355 11/18639 0.272727272727273 0.79989986410128 0.78194255096379 1 GO:0008083 growth factor activity 51/6355 162/18639 0.314814814814815 0.923341201153947 0.783673509933171 1 GO:1901682 sulfur compound transmembrane transporter activity 19/6355 63/18639 0.301587301587302 0.884545352365966 0.784572551771994 1 GO:0016790 thiolester hydrolase activity 13/6355 44/18639 0.295454545454545 0.86655818610972 0.7851797347221 1 GO:0019205 nucleobase-containing compound kinase activity 13/6355 44/18639 0.295454545454545 0.86655818610972 0.7851797347221 1 GO:0030547 signaling receptor inhibitor activity 13/6355 44/18639 0.295454545454545 0.86655818610972 0.7851797347221 1 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 18/6355 60/18639 0.3 0.879889850511408 0.788492124743319 1 GO:0003746 translation elongation factor activity 5/6355 18/18639 0.277777777777778 0.8147128245476 0.789161771110412 1 GO:0015172 acidic amino acid transmembrane transporter activity 5/6355 18/18639 0.277777777777778 0.8147128245476 0.789161771110412 1 GO:0015280 ligand-gated sodium channel activity 5/6355 18/18639 0.277777777777778 0.8147128245476 0.789161771110412 1 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 5/6355 18/18639 0.277777777777778 0.8147128245476 0.789161771110412 1 GO:0031690 adrenergic receptor binding 5/6355 18/18639 0.277777777777778 0.8147128245476 0.789161771110412 1 GO:0070628 proteasome binding 5/6355 18/18639 0.277777777777778 0.8147128245476 0.789161771110412 1 GO:0098641 cadherin binding involved in cell-cell adhesion 5/6355 18/18639 0.277777777777778 0.8147128245476 0.789161771110412 1 GO:0051119 sugar transmembrane transporter activity 8/6355 28/18639 0.285714285714286 0.837990333820389 0.790578761470967 1 GO:0001530 lipopolysaccharide binding 12/6355 41/18639 0.292682926829268 0.858429122450154 0.791377258343499 1 GO:0042287 MHC protein binding 12/6355 41/18639 0.292682926829268 0.858429122450154 0.791377258343499 1 GO:0015297 antiporter activity 42/6355 135/18639 0.311111111111111 0.912478363493312 0.794466433083913 1 GO:0005537 D-mannose binding 7/6355 25/18639 0.28 0.821230527143981 0.801607206109583 1 GO:0008139 nuclear localization sequence binding 7/6355 25/18639 0.28 0.821230527143981 0.801607206109583 1 GO:0047617 fatty acyl-CoA hydrolase activity 7/6355 25/18639 0.28 0.821230527143981 0.801607206109583 1 GO:0016830 carbon-carbon lyase activity 15/6355 51/18639 0.294117647058824 0.862637108344518 0.802294855688171 1 GO:0005154 epidermal growth factor receptor binding 10/6355 35/18639 0.285714285714286 0.837990333820389 0.806010278904117 1 GO:0004865 protein serine/threonine phosphatase inhibitor activity 4/6355 15/18639 0.266666666666667 0.782124311565696 0.808168027596632 1 GO:0004953 icosanoid receptor activity 4/6355 15/18639 0.266666666666667 0.782124311565696 0.808168027596632 1 GO:0015929 hexosaminidase activity 4/6355 15/18639 0.266666666666667 0.782124311565696 0.808168027596632 1 GO:0048531 beta-1,3-galactosyltransferase activity 4/6355 15/18639 0.266666666666667 0.782124311565696 0.808168027596632 1 GO:0008649 rRNA methyltransferase activity 6/6355 22/18639 0.272727272727273 0.79989986410128 0.814638103496694 1 GO:0140517 protein-RNA adaptor activity 6/6355 22/18639 0.272727272727273 0.79989986410128 0.814638103496694 1 GO:0140142 nucleocytoplasmic carrier activity 9/6355 32/18639 0.28125 0.824896734854445 0.814730572474434 1 GO:0106222 lncRNA binding 8/6355 29/18639 0.275862068965517 0.809094115412789 0.82464255919232 1 GO:0000217 DNA secondary structure binding 11/6355 39/18639 0.282051282051282 0.827246868002179 0.827390184588531 1 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 5/6355 19/18639 0.263157894736842 0.77183320220299 0.830287218399906 1 GO:0008301 DNA binding, bending 5/6355 19/18639 0.263157894736842 0.77183320220299 0.830287218399906 1 GO:0016918 retinal binding 5/6355 19/18639 0.263157894736842 0.77183320220299 0.830287218399906 1 GO:0022821 solute:potassium antiporter activity 5/6355 19/18639 0.263157894736842 0.77183320220299 0.830287218399906 1 GO:0030506 ankyrin binding 5/6355 19/18639 0.263157894736842 0.77183320220299 0.830287218399906 1 GO:0042577 lipid phosphatase activity 5/6355 19/18639 0.263157894736842 0.77183320220299 0.830287218399906 1 GO:0046624 sphingolipid transporter activity 5/6355 19/18639 0.263157894736842 0.77183320220299 0.830287218399906 1 GO:0015101 organic cation transmembrane transporter activity 24/6355 81/18639 0.296296296296296 0.869027012850774 0.83308089626543 1 GO:0003720 telomerase activity 3/6355 12/18639 0.25 0.73324154209284 0.833082037348027 1 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 3/6355 12/18639 0.25 0.73324154209284 0.833082037348027 1 GO:0010853 cyclase activator activity 3/6355 12/18639 0.25 0.73324154209284 0.833082037348027 1 GO:0015368 calcium:monoatomic cation antiporter activity 3/6355 12/18639 0.25 0.73324154209284 0.833082037348027 1 GO:0036009 protein-glutamine N-methyltransferase activity 3/6355 12/18639 0.25 0.73324154209284 0.833082037348027 1 GO:0042301 phosphate ion binding 3/6355 12/18639 0.25 0.73324154209284 0.833082037348027 1 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 3/6355 12/18639 0.25 0.73324154209284 0.833082037348027 1 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 3/6355 12/18639 0.25 0.73324154209284 0.833082037348027 1 GO:0004869 cysteine-type endopeptidase inhibitor activity 10/6355 36/18639 0.277777777777778 0.8147128245476 0.835369248387155 1 GO:0001637 G protein-coupled chemoattractant receptor activity 7/6355 26/18639 0.269230769230769 0.789644737638443 0.836009529179013 1 GO:0004950 chemokine receptor activity 7/6355 26/18639 0.269230769230769 0.789644737638443 0.836009529179013 1 GO:0015145 monosaccharide transmembrane transporter activity 7/6355 26/18639 0.269230769230769 0.789644737638443 0.836009529179013 1 GO:0016289 acyl-CoA hydrolase activity 7/6355 26/18639 0.269230769230769 0.789644737638443 0.836009529179013 1 GO:0019865 immunoglobulin binding 7/6355 26/18639 0.269230769230769 0.789644737638443 0.836009529179013 1 GO:0051139 metal cation:proton antiporter activity 7/6355 26/18639 0.269230769230769 0.789644737638443 0.836009529179013 1 GO:0030414 peptidase inhibitor activity 52/6355 169/18639 0.307692307692308 0.90245112872965 0.840823109320169 1 GO:0005283 amino acid:sodium symporter activity 6/6355 23/18639 0.260869565217391 0.765121609140355 0.849178594564332 1 GO:0016675 oxidoreductase activity, acting on a heme group of donors 4/6355 16/18639 0.25 0.73324154209284 0.84945776823631 1 GO:0019841 retinol binding 4/6355 16/18639 0.25 0.73324154209284 0.84945776823631 1 GO:0043023 ribosomal large subunit binding 4/6355 16/18639 0.25 0.73324154209284 0.84945776823631 1 GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 4/6355 16/18639 0.25 0.73324154209284 0.84945776823631 1 GO:0031210 phosphatidylcholine binding 8/6355 30/18639 0.266666666666667 0.782124311565696 0.854230772255315 1 GO:0048019 receptor antagonist activity 8/6355 30/18639 0.266666666666667 0.782124311565696 0.854230772255315 1 GO:0033293 monocarboxylic acid binding 23/6355 79/18639 0.291139240506329 0.853901542690396 0.854676474789856 1 GO:0003727 single-stranded RNA binding 26/6355 89/18639 0.292134831460674 0.856821577277027 0.861814321408948 1 GO:0001972 retinoic acid binding 5/6355 20/18639 0.25 0.73324154209284 0.864614377463995 1 GO:0015095 magnesium ion transmembrane transporter activity 5/6355 20/18639 0.25 0.73324154209284 0.864614377463995 1 GO:0061608 nuclear import signal receptor activity 5/6355 20/18639 0.25 0.73324154209284 0.864614377463995 1 GO:0070279 vitamin B6 binding 16/6355 57/18639 0.280701754385965 0.823288749016522 0.865400679915566 1 GO:0008266 poly(U) RNA binding 7/6355 27/18639 0.259259259259259 0.760398636244427 0.865479675860392 1 GO:0035255 ionotropic glutamate receptor binding 7/6355 27/18639 0.259259259259259 0.760398636244427 0.865479675860392 1 GO:0008135 translation factor activity, RNA binding 24/6355 83/18639 0.289156626506024 0.848086602902562 0.868057013533528 1 GO:0005200 structural constituent of cytoskeleton 33/6355 112/18639 0.294642857142857 0.864177531752276 0.872972560005571 1 GO:0003964 RNA-directed DNA polymerase activity 3/6355 13/18639 0.230769230769231 0.676838346547237 0.873522507334595 1 GO:0004465 lipoprotein lipase activity 3/6355 13/18639 0.230769230769231 0.676838346547237 0.873522507334595 1 GO:0004535 poly(A)-specific ribonuclease activity 3/6355 13/18639 0.230769230769231 0.676838346547237 0.873522507334595 1 GO:0015651 quaternary ammonium group transmembrane transporter activity 3/6355 13/18639 0.230769230769231 0.676838346547237 0.873522507334595 1 GO:0030955 potassium ion binding 3/6355 13/18639 0.230769230769231 0.676838346547237 0.873522507334595 1 GO:0004620 phospholipase activity 32/6355 109/18639 0.293577981651376 0.861054287962234 0.875283631840555 1 GO:0015175 neutral L-amino acid transmembrane transporter activity 11/6355 41/18639 0.268292682926829 0.786893362245975 0.875850544766629 1 GO:0016597 amino acid binding 14/6355 51/18639 0.274509803921569 0.805127967788217 0.876268925817383 1 GO:0005540 hyaluronic acid binding 6/6355 24/18639 0.25 0.73324154209284 0.878261368911113 1 GO:0015149 hexose transmembrane transporter activity 6/6355 24/18639 0.25 0.73324154209284 0.878261368911113 1 GO:0019957 C-C chemokine binding 6/6355 24/18639 0.25 0.73324154209284 0.878261368911113 1 GO:0030215 semaphorin receptor binding 6/6355 24/18639 0.25 0.73324154209284 0.878261368911113 1 GO:0055056 D-glucose transmembrane transporter activity 6/6355 24/18639 0.25 0.73324154209284 0.878261368911113 1 GO:0003678 DNA helicase activity 21/6355 74/18639 0.283783783783784 0.832328236970251 0.878563648037077 1 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 17/6355 61/18639 0.278688524590164 0.817384014136281 0.878793062359196 1 GO:0008327 methyl-CpG binding 8/6355 31/18639 0.258064516129032 0.756894495063577 0.879661010679811 1 GO:0004550 nucleoside diphosphate kinase activity 4/6355 17/18639 0.235294117647059 0.690109686675614 0.88294540409636 1 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 4/6355 17/18639 0.235294117647059 0.690109686675614 0.88294540409636 1 GO:0180051 translation factor activity 24/6355 84/18639 0.285714285714286 0.837990333820389 0.883293364142475 1 GO:0005242 inward rectifier potassium channel activity 7/6355 28/18639 0.25 0.73324154209284 0.890446647323534 1 GO:0045499 chemorepellent activity 7/6355 28/18639 0.25 0.73324154209284 0.890446647323534 1 GO:0051537 2 iron, 2 sulfur cluster binding 7/6355 28/18639 0.25 0.73324154209284 0.890446647323534 1 GO:0015125 bile acid transmembrane transporter activity 5/6355 21/18639 0.238095238095238 0.698325278183657 0.892889252226154 1 GO:0051428 peptide hormone receptor binding 5/6355 21/18639 0.238095238095238 0.698325278183657 0.892889252226154 1 GO:1904047 S-adenosyl-L-methionine binding 5/6355 21/18639 0.238095238095238 0.698325278183657 0.892889252226154 1 GO:0044183 protein folding chaperone 21/6355 75/18639 0.28 0.821230527143981 0.893626271649848 1 GO:0070888 E-box binding 16/6355 59/18639 0.271186440677966 0.795380655829522 0.899851981258335 1 GO:0035254 glutamate receptor binding 13/6355 49/18639 0.26530612244898 0.778133881404647 0.900007548488385 1 GO:0031406 carboxylic acid binding 56/6355 187/18639 0.299465240641711 0.878321419405327 0.900807913259287 1 GO:0001848 complement binding 6/6355 25/18639 0.24 0.703911880409127 0.902467946637912 1 GO:0008483 transaminase activity 6/6355 25/18639 0.24 0.703911880409127 0.902467946637912 1 GO:0015662 P-type ion transporter activity 6/6355 25/18639 0.24 0.703911880409127 0.902467946637912 1 GO:0140358 P-type transmembrane transporter activity 6/6355 25/18639 0.24 0.703911880409127 0.902467946637912 1 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 54/6355 181/18639 0.298342541436464 0.87502858061908 0.903240340539138 1 GO:0004935 adrenergic receptor activity 2/6355 10/18639 0.2 0.586593233674272 0.904628142184688 1 GO:0005345 purine nucleobase transmembrane transporter activity 2/6355 10/18639 0.2 0.586593233674272 0.904628142184688 1 GO:0015203 polyamine transmembrane transporter activity 2/6355 10/18639 0.2 0.586593233674272 0.904628142184688 1 GO:0016868 intramolecular phosphotransferase activity 2/6355 10/18639 0.2 0.586593233674272 0.904628142184688 1 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 2/6355 10/18639 0.2 0.586593233674272 0.904628142184688 1 GO:0016889 DNA endonuclease activity, producing 3'-phosphomonoesters 2/6355 10/18639 0.2 0.586593233674272 0.904628142184688 1 GO:0019911 structural constituent of myelin sheath 2/6355 10/18639 0.2 0.586593233674272 0.904628142184688 1 GO:0031419 cobalamin binding 2/6355 10/18639 0.2 0.586593233674272 0.904628142184688 1 GO:0032052 bile acid binding 2/6355 10/18639 0.2 0.586593233674272 0.904628142184688 1 GO:0043295 glutathione binding 2/6355 10/18639 0.2 0.586593233674272 0.904628142184688 1 GO:0097177 mitochondrial ribosome binding 2/6355 10/18639 0.2 0.586593233674272 0.904628142184688 1 GO:0140135 mechanosensitive monoatomic cation channel activity 2/6355 10/18639 0.2 0.586593233674272 0.904628142184688 1 GO:0140940 histone H2A methyltransferase activity 2/6355 10/18639 0.2 0.586593233674272 0.904628142184688 1 GO:1990259 histone H2AQ104 methyltransferase activity 2/6355 10/18639 0.2 0.586593233674272 0.904628142184688 1 GO:0030170 pyridoxal phosphate binding 15/6355 56/18639 0.267857142857143 0.785615937956615 0.904794318378142 1 GO:0008195 phosphatidate phosphatase activity 3/6355 14/18639 0.214285714285714 0.628492750365292 0.905016910427031 1 GO:0015926 glucosidase activity 3/6355 14/18639 0.214285714285714 0.628492750365292 0.905016910427031 1 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 3/6355 14/18639 0.214285714285714 0.628492750365292 0.905016910427031 1 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 3/6355 14/18639 0.214285714285714 0.628492750365292 0.905016910427031 1 GO:1901474 azole transmembrane transporter activity 3/6355 14/18639 0.214285714285714 0.628492750365292 0.905016910427031 1 GO:1990825 sequence-specific mRNA binding 3/6355 14/18639 0.214285714285714 0.628492750365292 0.905016910427031 1 GO:0098631 cell adhesion mediator activity 21/6355 76/18639 0.276315789473684 0.810424862313139 0.907158025688763 1 GO:0016209 antioxidant activity 24/6355 86/18639 0.27906976744186 0.81850218652224 0.90959964314013 1 GO:0000400 four-way junction DNA binding 4/6355 18/18639 0.222222222222222 0.65177025963808 0.909740727806631 1 GO:0008146 sulfotransferase activity 14/6355 53/18639 0.264150943396226 0.77474578032451 0.90999950164206 1 GO:0004181 metallocarboxypeptidase activity 7/6355 29/18639 0.241379310344828 0.707957350986191 0.91138431172892 1 GO:0033691 sialic acid binding 5/6355 22/18639 0.227272727272727 0.6665832200844 0.915904295970112 1 GO:0070034 telomerase RNA binding 5/6355 22/18639 0.227272727272727 0.6665832200844 0.915904295970112 1 GO:0043177 organic acid binding 56/6355 189/18639 0.296296296296296 0.869027012850774 0.917273584365687 1 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 8/6355 33/18639 0.242424242424242 0.71102210142336 0.919558200704296 1 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 10/6355 40/18639 0.25 0.73324154209284 0.919620335345418 1 GO:0005504 fatty acid binding 12/6355 47/18639 0.25531914893617 0.748842425967156 0.921259241548636 1 GO:0008143 poly(A) binding 6/6355 26/18639 0.230769230769231 0.676838346547237 0.922405471875582 1 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 25/6355 91/18639 0.274725274725275 0.805759936365759 0.928137200646922 1 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 7/6355 30/18639 0.233333333333333 0.684358772619984 0.928778867220887 1 GO:0008187 poly-pyrimidine tract binding 7/6355 30/18639 0.233333333333333 0.684358772619984 0.928778867220887 1 GO:0016769 transferase activity, transferring nitrogenous groups 7/6355 30/18639 0.233333333333333 0.684358772619984 0.928778867220887 1 GO:0004129 cytochrome-c oxidase activity 3/6355 15/18639 0.2 0.586593233674272 0.92922913113463 1 GO:0010181 FMN binding 3/6355 15/18639 0.2 0.586593233674272 0.92922913113463 1 GO:0015556 C4-dicarboxylate transmembrane transporter activity 3/6355 15/18639 0.2 0.586593233674272 0.92922913113463 1 GO:0016846 carbon-sulfur lyase activity 3/6355 15/18639 0.2 0.586593233674272 0.92922913113463 1 GO:0030553 cGMP binding 3/6355 15/18639 0.2 0.586593233674272 0.92922913113463 1 GO:0031386 protein tag activity 3/6355 15/18639 0.2 0.586593233674272 0.92922913113463 1 GO:0055105 ubiquitin-protein transferase inhibitor activity 3/6355 15/18639 0.2 0.586593233674272 0.92922913113463 1 GO:0140161 monocarboxylate:sodium symporter activity 3/6355 15/18639 0.2 0.586593233674272 0.92922913113463 1 GO:0141047 molecular tag activity 3/6355 15/18639 0.2 0.586593233674272 0.92922913113463 1 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 4/6355 19/18639 0.210526315789474 0.617466561762392 0.93092833031509 1 GO:0008381 mechanosensitive monoatomic ion channel activity 4/6355 19/18639 0.210526315789474 0.617466561762392 0.93092833031509 1 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 4/6355 19/18639 0.210526315789474 0.617466561762392 0.93092833031509 1 GO:0031420 alkali metal ion binding 4/6355 19/18639 0.210526315789474 0.617466561762392 0.93092833031509 1 GO:0042834 peptidoglycan binding 4/6355 19/18639 0.210526315789474 0.617466561762392 0.93092833031509 1 GO:0008271 secondary active sulfate transmembrane transporter activity 2/6355 11/18639 0.181818181818182 0.53326657606752 0.931891606900444 1 GO:0015205 nucleobase transmembrane transporter activity 2/6355 11/18639 0.181818181818182 0.53326657606752 0.931891606900444 1 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 2/6355 11/18639 0.181818181818182 0.53326657606752 0.931891606900444 1 GO:0019206 nucleoside kinase activity 2/6355 11/18639 0.181818181818182 0.53326657606752 0.931891606900444 1 GO:0019215 intermediate filament binding 2/6355 11/18639 0.181818181818182 0.53326657606752 0.931891606900444 1 GO:0034511 U3 snoRNA binding 2/6355 11/18639 0.181818181818182 0.53326657606752 0.931891606900444 1 GO:0035252 UDP-xylosyltransferase activity 2/6355 11/18639 0.181818181818182 0.53326657606752 0.931891606900444 1 GO:0042285 xylosyltransferase activity 2/6355 11/18639 0.181818181818182 0.53326657606752 0.931891606900444 1 GO:1900750 oligopeptide binding 2/6355 11/18639 0.181818181818182 0.53326657606752 0.931891606900444 1 GO:1990948 ubiquitin ligase inhibitor activity 2/6355 11/18639 0.181818181818182 0.53326657606752 0.931891606900444 1 GO:0140828 metal cation:monoatomic cation antiporter activity 10/6355 41/18639 0.24390243902439 0.715357602041795 0.933739622628899 1 GO:0019843 rRNA binding 17/6355 65/18639 0.261538461538462 0.767083459420202 0.933791680978796 1 GO:0016493 C-C chemokine receptor activity 5/6355 23/18639 0.217391304347826 0.637601340950296 0.934439213027274 1 GO:0098632 cell-cell adhesion mediator activity 14/6355 55/18639 0.254545454545455 0.746573206494528 0.935717729943609 1 GO:0042379 chemokine receptor binding 19/6355 72/18639 0.263888888888889 0.77397718332022 0.936634722434784 1 GO:0015171 amino acid transmembrane transporter activity 28/6355 102/18639 0.274509803921569 0.805127967788217 0.938402889537058 1 GO:0004364 glutathione transferase activity 6/6355 27/18639 0.222222222222222 0.65177025963808 0.938669985022779 1 GO:0008395 steroid hydroxylase activity 6/6355 27/18639 0.222222222222222 0.65177025963808 0.938669985022779 1 GO:0005501 retinoid binding 9/6355 38/18639 0.236842105263158 0.694649881982691 0.940457159065089 1 GO:0019840 isoprenoid binding 9/6355 38/18639 0.236842105263158 0.694649881982691 0.940457159065089 1 GO:0015459 potassium channel regulator activity 15/6355 59/18639 0.254237288135593 0.745669364840177 0.941819980681131 1 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 15/6355 59/18639 0.254237288135593 0.745669364840177 0.941819980681131 1 GO:0005452 solute:inorganic anion antiporter activity 7/6355 31/18639 0.225806451612903 0.66228268318063 0.943104908712034 1 GO:0072349 modified amino acid transmembrane transporter activity 7/6355 31/18639 0.225806451612903 0.66228268318063 0.943104908712034 1 GO:0016829 lyase activity 58/6355 200/18639 0.29 0.850560188827695 0.947081807594319 1 GO:0005343 organic acid:sodium symporter activity 8/6355 35/18639 0.228571428571429 0.670392267056311 0.947487910096549 1 GO:0140664 ATP-dependent DNA damage sensor activity 4/6355 20/18639 0.2 0.586593233674272 0.947506818527864 1 GO:0015378 sodium:chloride symporter activity 3/6355 16/18639 0.1875 0.54993115656963 0.947637907188089 1 GO:0008028 monocarboxylic acid transmembrane transporter activity 18/6355 70/18639 0.257142857142857 0.75419130043835 0.948933595412627 1 GO:0048027 mRNA 5'-UTR binding 5/6355 24/18639 0.208333333333333 0.6110346184107 0.949222856215737 1 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 11/6355 46/18639 0.239130434782609 0.701361475045326 0.950431899198571 1 GO:0004126 cytidine deaminase activity 2/6355 12/18639 0.166666666666667 0.48882769472856 0.951653520810927 1 GO:0004300 enoyl-CoA hydratase activity 2/6355 12/18639 0.166666666666667 0.48882769472856 0.951653520810927 1 GO:0004859 phospholipase inhibitor activity 2/6355 12/18639 0.166666666666667 0.48882769472856 0.951653520810927 1 GO:0015166 polyol transmembrane transporter activity 2/6355 12/18639 0.166666666666667 0.48882769472856 0.951653520810927 1 GO:0097371 MDM2/MDM4 family protein binding 2/6355 12/18639 0.166666666666667 0.48882769472856 0.951653520810927 1 GO:0140829 bicarbonate:monoatomic anion antiporter activity 2/6355 12/18639 0.166666666666667 0.48882769472856 0.951653520810927 1 GO:0140900 chloride:bicarbonate antiporter activity 2/6355 12/18639 0.166666666666667 0.48882769472856 0.951653520810927 1 GO:1990817 poly(A) RNA polymerase activity 2/6355 12/18639 0.166666666666667 0.48882769472856 0.951653520810927 1 GO:0017171 serine hydrolase activity 57/6355 198/18639 0.287878787878788 0.84433874544024 0.953021944960403 1 GO:0070717 poly-purine tract binding 7/6355 32/18639 0.21875 0.641586349331235 0.954809025928555 1 GO:0045505 dynein intermediate chain binding 8/6355 36/18639 0.222222222222222 0.65177025963808 0.957917968625073 1 GO:0015271 outward rectifier potassium channel activity 5/6355 25/18639 0.2 0.586593233674272 0.960911583610193 1 GO:0017056 structural constituent of nuclear pore 5/6355 25/18639 0.2 0.586593233674272 0.960911583610193 1 GO:0009881 photoreceptor activity 3/6355 17/18639 0.176470588235294 0.517582265006711 0.961500586422031 1 GO:0015347 sodium-independent organic anion transmembrane transporter activity 3/6355 17/18639 0.176470588235294 0.517582265006711 0.961500586422031 1 GO:0030548 acetylcholine receptor regulator activity 3/6355 17/18639 0.176470588235294 0.517582265006711 0.961500586422031 1 GO:0005416 amino acid:monoatomic cation symporter activity 6/6355 29/18639 0.206896551724138 0.606820586559592 0.96237071552566 1 GO:0008236 serine-type peptidase activity 55/6355 194/18639 0.283505154639175 0.831511027115592 0.963469340400309 1 GO:0002161 aminoacyl-tRNA editing activity 2/6355 13/18639 0.153846153846154 0.451225564364825 0.965859159624806 1 GO:0071837 HMG box domain binding 2/6355 13/18639 0.153846153846154 0.451225564364825 0.965859159624806 1 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 2/6355 13/18639 0.153846153846154 0.451225564364825 0.965859159624806 1 GO:0140410 monoatomic cation:bicarbonate symporter activity 2/6355 13/18639 0.153846153846154 0.451225564364825 0.965859159624806 1 GO:0140666 annealing activity 2/6355 13/18639 0.153846153846154 0.451225564364825 0.965859159624806 1 GO:0015399 primary active transmembrane transporter activity 46/6355 166/18639 0.27710843373494 0.812749661114956 0.967745128530325 1 GO:0008970 phospholipase A1 activity 4/6355 22/18639 0.181818181818182 0.53326657606752 0.970236613849686 1 GO:0004970 glutamate-gated receptor activity 3/6355 18/18639 0.166666666666667 0.48882769472856 0.971852558145111 1 GO:0015373 monoatomic anion:sodium symporter activity 3/6355 18/18639 0.166666666666667 0.48882769472856 0.971852558145111 1 GO:0017128 phospholipid scramblase activity 3/6355 18/18639 0.166666666666667 0.48882769472856 0.971852558145111 1 GO:0099602 neurotransmitter receptor regulator activity 3/6355 18/18639 0.166666666666667 0.48882769472856 0.971852558145111 1 GO:0016860 intramolecular oxidoreductase activity 12/6355 53/18639 0.226415094339623 0.664067811706723 0.97505321551927 1 GO:0005313 L-glutamate transmembrane transporter activity 2/6355 14/18639 0.142857142857143 0.418995166910194 0.975999534491102 1 GO:0005344 oxygen carrier activity 2/6355 14/18639 0.142857142857143 0.418995166910194 0.975999534491102 1 GO:0008392 arachidonate epoxygenase activity 2/6355 14/18639 0.142857142857143 0.418995166910194 0.975999534491102 1 GO:0043176 amine binding 2/6355 14/18639 0.142857142857143 0.418995166910194 0.975999534491102 1 GO:0004601 peroxidase activity 13/6355 57/18639 0.228070175438596 0.668922108575924 0.976981355255881 1 GO:0048020 CCR chemokine receptor binding 11/6355 50/18639 0.22 0.645252557041699 0.978149453483509 1 GO:0016836 hydro-lyase activity 14/6355 61/18639 0.229508196721311 0.673139776347526 0.978789499017863 1 GO:0034987 immunoglobulin receptor binding 3/6355 19/18639 0.157894736842105 0.463099921321794 0.97952585086324 1 GO:0019842 vitamin binding 40/6355 150/18639 0.266666666666667 0.782124311565696 0.979649102332302 1 GO:0030515 snoRNA binding 6/6355 32/18639 0.1875 0.54993115656963 0.982623125875454 1 GO:0004089 carbonate dehydratase activity 2/6355 15/18639 0.133333333333333 0.391062155782848 0.983194981161328 1 GO:0015116 sulfate transmembrane transporter activity 2/6355 15/18639 0.133333333333333 0.391062155782848 0.983194981161328 1 GO:0015250 water channel activity 2/6355 15/18639 0.133333333333333 0.391062155782848 0.983194981161328 1 GO:0034483 heparan sulfate sulfotransferase activity 2/6355 15/18639 0.133333333333333 0.391062155782848 0.983194981161328 1 GO:0050997 quaternary ammonium group binding 8/6355 40/18639 0.2 0.586593233674272 0.983469686305271 1 GO:0140662 ATP-dependent protein folding chaperone 8/6355 40/18639 0.2 0.586593233674272 0.983469686305271 1 GO:0003796 lysozyme activity 1/6355 10/18639 0.1 0.293296616837136 0.984560638909556 1 GO:0008401 retinoic acid 4-hydroxylase activity 1/6355 10/18639 0.1 0.293296616837136 0.984560638909556 1 GO:0008519 ammonium channel activity 1/6355 10/18639 0.1 0.293296616837136 0.984560638909556 1 GO:0015187 glycine transmembrane transporter activity 1/6355 10/18639 0.1 0.293296616837136 0.984560638909556 1 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1/6355 10/18639 0.1 0.293296616837136 0.984560638909556 1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 1/6355 10/18639 0.1 0.293296616837136 0.984560638909556 1 GO:0042166 acetylcholine binding 1/6355 10/18639 0.1 0.293296616837136 0.984560638909556 1 GO:0051378 serotonin binding 1/6355 10/18639 0.1 0.293296616837136 0.984560638909556 1 GO:0046982 protein heterodimerization activity 107/6355 369/18639 0.289972899728997 0.85048070464969 0.984803082660885 1 GO:0015291 secondary active transmembrane transporter activity 81/6355 287/18639 0.282229965156794 0.827770939505506 0.986288657162005 1 GO:0031491 nucleosome binding 17/6355 74/18639 0.22972972972973 0.673789525166394 0.986334322690385 1 GO:0008514 organic anion transmembrane transporter activity 75/6355 269/18639 0.278810408921933 0.817741496757814 0.98812791592172 1 GO:0008391 arachidonate monooxygenase activity 2/6355 16/18639 0.125 0.36662077104642 0.988274563157505 1 GO:0005544 calcium-dependent phospholipid binding 11/6355 53/18639 0.207547169811321 0.60872882739783 0.98867198492864 1 GO:0070182 DNA polymerase binding 3/6355 21/18639 0.142857142857143 0.418995166910194 0.989312644623411 1 GO:0016835 carbon-oxygen lyase activity 18/6355 79/18639 0.227848101265823 0.66827077254031 0.98958385434324 1 GO:0005536 D-glucose binding 1/6355 11/18639 0.0909090909090909 0.26663328803376 0.989827542110467 1 GO:0016594 glycine binding 1/6355 11/18639 0.0909090909090909 0.26663328803376 0.989827542110467 1 GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 1/6355 11/18639 0.0909090909090909 0.26663328803376 0.989827542110467 1 GO:0099528 G protein-coupled neurotransmitter receptor activity 1/6355 11/18639 0.0909090909090909 0.26663328803376 0.989827542110467 1 GO:0015020 glucuronosyltransferase activity 6/6355 34/18639 0.176470588235294 0.517582265006711 0.989856437888432 1 GO:0008569 minus-end-directed microtubule motor activity 2/6355 17/18639 0.117647058823529 0.345054843337807 0.991844426722235 1 GO:0016874 ligase activity 43/6355 167/18639 0.25748502994012 0.755194881676458 0.992147446939556 1 GO:0005243 gap junction channel activity 3/6355 22/18639 0.136363636363636 0.39994993205064 0.99232464948242 1 GO:0004867 serine-type endopeptidase inhibitor activity 22/6355 95/18639 0.231578947368421 0.679213217938631 0.992479328863066 1 GO:0005272 sodium channel activity 10/6355 51/18639 0.196078431372549 0.575091405563012 0.992533171261622 1 GO:0005125 cytokine activity 63/6355 234/18639 0.269230769230769 0.789644737638443 0.992633764560873 1 GO:0047499 calcium-independent phospholipase A2 activity 5/6355 31/18639 0.161290322580645 0.473059059414736 0.992690406499935 1 GO:0036002 pre-mRNA binding 12/6355 59/18639 0.203389830508475 0.596535491872141 0.993147714327241 1 GO:0004032 aldose reductase (NADPH) activity 1/6355 12/18639 0.0833333333333333 0.24441384736428 0.993297907683152 1 GO:0005436 sodium:phosphate symporter activity 1/6355 12/18639 0.0833333333333333 0.24441384736428 0.993297907683152 1 GO:0015269 calcium-activated potassium channel activity 1/6355 12/18639 0.0833333333333333 0.24441384736428 0.993297907683152 1 GO:0004252 serine-type endopeptidase activity 45/6355 176/18639 0.255681818181818 0.74990612259495 0.994296119446268 1 GO:0005372 water transmembrane transporter activity 2/6355 18/18639 0.111111111111111 0.32588512981904 0.994343410294376 1 GO:0022851 GABA-gated chloride ion channel activity 2/6355 18/18639 0.111111111111111 0.32588512981904 0.994343410294376 1 GO:0016917 GABA receptor activity 3/6355 23/18639 0.130434782608696 0.382560804570177 0.994507410590833 1 GO:0099186 structural constituent of postsynapse 3/6355 23/18639 0.130434782608696 0.382560804570177 0.994507410590833 1 GO:0004993 G protein-coupled serotonin receptor activity 1/6355 13/18639 0.0769230769230769 0.225612782182412 0.995584470021348 1 GO:0005542 folic acid binding 1/6355 13/18639 0.0769230769230769 0.225612782182412 0.995584470021348 1 GO:0022829 wide pore channel activity 6/6355 37/18639 0.162162162162162 0.475616135411572 0.995609930837467 1 GO:0009055 electron transfer activity 27/6355 116/18639 0.232758620689655 0.682673159879541 0.995838181956779 1 GO:0004890 GABA-A receptor activity 2/6355 19/18639 0.105263157894737 0.308733280881196 0.996086652580392 1 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 8/6355 46/18639 0.173913043478261 0.510081072760237 0.996404731288214 1 GO:0020037 heme binding 34/6355 142/18639 0.23943661971831 0.702259505103002 0.996753897102248 1 GO:0061783 peptidoglycan muralytic activity 1/6355 14/18639 0.0714285714285714 0.209497583455097 0.997091003523674 1 GO:0005251 delayed rectifier potassium channel activity 3/6355 25/18639 0.12 0.351955940204563 0.997214172007693 1 GO:0022843 voltage-gated monoatomic cation channel activity 34/6355 143/18639 0.237762237762238 0.697348599472911 0.997250486373444 1 GO:0046943 carboxylic acid transmembrane transporter activity 47/6355 188/18639 0.25 0.73324154209284 0.997325734495326 1 GO:0098918 structural constituent of synapse 4/6355 30/18639 0.133333333333333 0.391062155782848 0.997447898534726 1 GO:0005342 organic acid transmembrane transporter activity 47/6355 189/18639 0.248677248677249 0.729361957214042 0.997695816555636 1 GO:0015103 inorganic anion transmembrane transporter activity 40/6355 165/18639 0.242424242424242 0.71102210142336 0.997718357819136 1 GO:0004623 phospholipase A2 activity 5/6355 35/18639 0.142857142857143 0.418995166910194 0.997795634936244 1 GO:0005227 calcium-activated cation channel activity 3/6355 26/18639 0.115384615384615 0.338419173273619 0.998024603937808 1 GO:0008066 glutamate receptor activity 3/6355 26/18639 0.115384615384615 0.338419173273619 0.998024603937808 1 GO:0046906 tetrapyrrole binding 36/6355 152/18639 0.236842105263158 0.694649881982691 0.998034105389897 1 GO:0008020 G protein-coupled photoreceptor activity 1/6355 15/18639 0.0666666666666667 0.195531077891424 0.998083576549556 1 GO:0005248 voltage-gated sodium channel activity 2/6355 21/18639 0.0952380952380952 0.279330111273463 0.998139577799081 1 GO:0016651 oxidoreductase activity, acting on NAD(P)H 18/6355 88/18639 0.204545454545455 0.59992489807596 0.99832381806559 1 GO:0005253 monoatomic anion channel activity 22/6355 103/18639 0.213592233009709 0.626458793244368 0.998378075884179 1 GO:0022853 active monoatomic ion transmembrane transporter activity 26/6355 118/18639 0.220338983050847 0.646246782861486 0.998505438691352 1 GO:0022804 active transmembrane transporter activity 127/6355 457/18639 0.277899343544858 0.815069372829678 0.9985259792494 1 GO:0022832 voltage-gated channel activity 42/6355 175/18639 0.24 0.703911880409127 0.998604004715077 1 GO:0004812 aminoacyl-tRNA ligase activity 6/6355 41/18639 0.146341463414634 0.429214561225077 0.998630335574577 1 GO:0016875 ligase activity, forming carbon-oxygen bonds 6/6355 41/18639 0.146341463414634 0.429214561225077 0.998630335574577 1 GO:0015106 bicarbonate transmembrane transporter activity 4/6355 32/18639 0.125 0.36662077104642 0.998666711375627 1 GO:0047498 calcium-dependent phospholipase A2 activity 4/6355 32/18639 0.125 0.36662077104642 0.998666711375627 1 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity 1/6355 16/18639 0.0625 0.18331038552321 0.998737510775693 1 GO:0005244 voltage-gated monoatomic ion channel activity 41/6355 173/18639 0.236994219653179 0.695096028342346 0.998904193660798 1 GO:0015108 chloride transmembrane transporter activity 26/6355 121/18639 0.214876033057851 0.630224135352524 0.999164051865869 1 GO:0019825 oxygen binding 4/6355 34/18639 0.117647058823529 0.345054843337807 0.99931096393639 1 GO:1901611 phosphatidylglycerol binding 1/6355 18/18639 0.0555555555555556 0.16294256490952 0.99945214724872 1 GO:0015294 solute:monoatomic cation symporter activity 24/6355 116/18639 0.206896551724138 0.606820586559592 0.999482472197155 1 GO:0008509 monoatomic anion transmembrane transporter activity 33/6355 149/18639 0.221476510067114 0.649583111115805 0.99949008109723 1 GO:0022839 monoatomic ion-gated channel activity 3/6355 30/18639 0.1 0.293296616837136 0.999512740620635 1 GO:0071855 neuropeptide receptor binding 5/6355 40/18639 0.125 0.36662077104642 0.999539948934511 1 GO:0005254 chloride channel activity 15/6355 83/18639 0.180722891566265 0.530054126814101 0.999624572064317 1 GO:0005229 intracellularly calcium-gated chloride channel activity 1/6355 19/18639 0.0526315789473684 0.154366640440598 0.999639119174738 1 GO:0099589 serotonin receptor activity 1/6355 19/18639 0.0526315789473684 0.154366640440598 0.999639119174738 1 GO:0141147 intracellularly calcium-gated channel activity 1/6355 19/18639 0.0526315789473684 0.154366640440598 0.999639119174738 1 GO:0005184 neuropeptide hormone activity 3/6355 31/18639 0.0967741935483871 0.283835435648841 0.999658457954684 1 GO:0005310 dicarboxylic acid transmembrane transporter activity 3/6355 31/18639 0.0967741935483871 0.283835435648841 0.999658457954684 1 GO:0008227 G protein-coupled amine receptor activity 5/6355 41/18639 0.121951219512195 0.357678801020898 0.999666284123391 1 GO:0031492 nucleosomal DNA binding 5/6355 42/18639 0.119047619047619 0.349162639091829 0.999758478705676 1 GO:0160041 neuropeptide activity 3/6355 32/18639 0.09375 0.274965578284815 0.99976105242838 1 GO:0005326 neurotransmitter transmembrane transporter activity 1/6355 20/18639 0.05 0.146648308418568 0.999762287684112 1 GO:0015464 acetylcholine receptor activity 1/6355 20/18639 0.05 0.146648308418568 0.999762287684112 1 GO:0015293 symporter activity 31/6355 146/18639 0.212328767123288 0.622753090544604 0.999774860878079 1 GO:0015252 proton channel activity 2/6355 27/18639 0.0740740740740741 0.217256753212693 0.99980832927013 1 GO:0008527 taste receptor activity 2/6355 28/18639 0.0714285714285714 0.209497583455097 0.999869401275946 1 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 3/6355 34/18639 0.0882352941176471 0.258791132503355 0.999883660289029 1 GO:0033038 bitter taste receptor activity 1/6355 22/18639 0.0454545454545455 0.13331664401688 0.999896868537774 1 GO:0001653 peptide receptor activity 25/6355 128/18639 0.1953125 0.572844954760031 0.999910156194885 1 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 10/6355 68/18639 0.147058823529412 0.431318554172259 0.999914226427003 1 GO:0005249 voltage-gated potassium channel activity 17/6355 98/18639 0.173469387755102 0.508779845533808 0.999932745637703 1 GO:0008528 G protein-coupled peptide receptor activity 23/6355 122/18639 0.188524590163934 0.552936244856896 0.999938225858352 1 GO:0015079 potassium ion transmembrane transporter activity 33/6355 160/18639 0.20625 0.604924272226593 0.999939917311749 1 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 3/6355 36/18639 0.0833333333333333 0.24441384736428 0.999943718060568 1 GO:0005267 potassium channel activity 23/6355 124/18639 0.185483870967742 0.544017918326946 0.999960895446676 1 GO:0030280 structural constituent of skin epidermis 3/6355 37/18639 0.0810810810810811 0.237808067705786 0.999960939734097 1 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 7/6355 58/18639 0.120689655172414 0.353978675493095 0.999969867765624 1 GO:0004497 monooxygenase activity 18/6355 106/18639 0.169811320754717 0.498050858780042 0.999974925093088 1 GO:0015078 proton transmembrane transporter activity 38/6355 185/18639 0.205405405405405 0.602447104854658 0.999983594015894 1 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 6/6355 56/18639 0.107142857142857 0.314246375182646 0.999987837244428 1 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 5/6355 53/18639 0.0943396226415094 0.276694921544468 0.999993923193643 1 GO:0015370 solute:sodium symporter activity 10/6355 79/18639 0.126582278481013 0.371261540300172 0.999996594290855 1 GO:0003823 antigen binding 33/6355 174/18639 0.189655172413793 0.556252204346293 0.999996927745169 1 GO:0099094 ligand-gated monoatomic cation channel activity 23/6355 136/18639 0.169117647058824 0.496016337298098 0.999997786846836 1 GO:0046873 metal ion transmembrane transporter activity 109/6355 450/18639 0.242222222222222 0.710429583005507 0.999998314400318 1 GO:0022824 transmitter-gated monoatomic ion channel activity 6/6355 63/18639 0.0952380952380952 0.279330111273463 0.999998830400332 1 GO:0022835 transmitter-gated channel activity 6/6355 63/18639 0.0952380952380952 0.279330111273463 0.999998830400332 1 GO:0042923 neuropeptide binding 1/6355 33/18639 0.0303030303030303 0.08887776267792 0.999998957937782 1 GO:0099095 ligand-gated monoatomic anion channel activity 3/6355 47/18639 0.0638297872340425 0.187210606491789 0.999999051835974 1 GO:0008137 NADH dehydrogenase (ubiquinone) activity 2/6355 41/18639 0.0487804878048781 0.143071520408359 0.999999180361881 1 GO:0015081 sodium ion transmembrane transporter activity 28/6355 164/18639 0.170731707317073 0.500750321429257 0.999999676409256 1 GO:0005179 hormone activity 20/6355 132/18639 0.151515151515152 0.4443888133896 0.999999747816451 1 GO:0003954 NADH dehydrogenase activity 2/6355 44/18639 0.0454545454545455 0.13331664401688 0.999999749798267 1 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 7/6355 73/18639 0.0958904109589041 0.281243331213692 0.99999977382529 1 GO:0098960 postsynaptic neurotransmitter receptor activity 6/6355 69/18639 0.0869565217391304 0.255040536380118 0.999999850537431 1 GO:0008188 neuropeptide receptor activity 2/6355 48/18639 0.0416666666666667 0.12220692368214 0.999999948930342 1 GO:0030594 neurotransmitter receptor activity 10/6355 97/18639 0.103092783505155 0.302367646223852 0.999999988099361 1 GO:0005261 monoatomic cation channel activity 70/6355 341/18639 0.205278592375367 0.602075166527845 0.999999990392791 1 GO:0015276 ligand-gated monoatomic ion channel activity 27/6355 186/18639 0.145161290322581 0.425753153473262 0.999999999630391 1 GO:0022834 ligand-gated channel activity 27/6355 188/18639 0.143617021276596 0.421223864606525 0.999999999786073 1 GO:0022836 gated channel activity 59/6355 318/18639 0.185534591194969 0.544166679037454 0.999999999809059 1 GO:0005216 monoatomic ion channel activity 92/6355 448/18639 0.205357142857143 0.602305552433405 0.999999999939705 1 GO:0003730 mRNA 3'-UTR binding 41/6355 262/18639 0.156488549618321 0.458975621768037 0.999999999995853 1 GO:0003735 structural constituent of ribosome 12/6355 175/18639 0.0685714285714286 0.201117680116893 1 1 GO:0030371 translation repressor activity 16/6355 329/18639 0.0486322188449848 0.142636652565173 1 1 GO:0045182 translation regulator activity 23/6355 356/18639 0.0646067415730337 0.189489387282419 1 1 GO:1903231 mRNA base-pairing translational repressor activity 3/6355 298/18639 0.0100671140939597 0.0295265050507184 1 1