category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	96/1451	250/9376	2.4813121984838	VAMP8/CTSS/CLTB/LAPTM5/HEXB/CTSD/CD68/ACP5/LGMN/ASAH1/CTSB/LIPA/CTSZ/PSAP/SLC11A1/SLC15A3/GNS/TPP1/RRAGD/SLC17A5/PPT1/TLR3/SLC11A2/ACP2/CTSA/LAPTM4A/CTBS/GNPTG/LAMP2/ABCA5/AP1S2/SCARB2/NAGLU/ATP6V0E1/AP2A2/DMXL2/SLC29A3/ATP6AP1/ATP6V1B2/MCOLN1/ATP6V1C1/TPCN1/VAMP7/ATP6V1G1/GGA1/CLCN7/ENTPD4/DTNBP1/MITF/HGSNAT/CTSO/BLOC1S2/IDS/BLOC1S6/CTSH/HEXA/AP3S1/GGA2/M6PR/ARSA/GALC/AP5B1/VPS13C/CD63/ATP6V0D1/TLR7/AP2M1/LAMTOR5/SMPD1/ROGDI/TCIRG1/GPR155/CTNS/BLOC1S1/VPS35/SUMF1/MANBA/SNAPIN/FUCA2/OSTM1/ATP6V0B/PLA2G15/ATP6V1F/CLTC/DNASE2/FIG4/AP4E1/NAGPA/RAB7A/GGA3/RRAGB/NPC1/AP5Z1/GUSB/ARL8A/LAMTOR2	10.1577163301736
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	74/1451	181/9376	2.64182065331206	HLA-DRA/CD74/HLA-DRB1/HLA-DPA1/HLA-DPB1/CTSS/CTSD/HLA-DQB1/FCER1G/HLA-DQA1/ITGB2/HLA-DMA/FCGR3A/HLA-DMB/LSP1/PLK3/CD14/HLA-DQA2/IL18/FCGR1A/ITGAX/LAMP2/FCGR2A/STAT1/HLA-DRB5/SYK/TRADD/IL1B/ITGAM/ATP6AP1/HLA-DOA/BID/IL10/CEBPB/IFNGR1/CORO1A/ARHGEF12/JAK2/TLR4/TLR1/BAD/TLR2/RELA/RAB5C/CAMK2D/CAMK2G/CIITA/ATP6V0D1/CEBPG/TCIRG1/IRAK4/TNF/VDR/FADD/MAPK8/CARD9/IL1A/FCGR3B/NFKB1/ATP6V0B/TGFB1/CLEC4E/FCGR2B/CREBBP/IL10RA/CALM2/CLEC7A/RAB7A/CASP8/PPP3R1/EP300/MAPK1/NFYA/SPHK1	9.54352563047277
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	43/1451	78/9376	3.56224707982117	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DQB1/HLA-DQA1/ITGB2/HLA-DMA/FCGR3A/HLA-DMB/NCF2/HLA-DQA2/CYBB/FCGR1A/NCF4/NFKBIA/PTPN6/FCGR2A/STAT1/HLA-DRB5/IL1B/ITGAM/ELK1/HLA-DOA/IL10/IFNGR1/PTGS2/JAK2/TLR4/PRKCB/TLR2/RELA/TAB2/IRAK4/TNF/IL1A/FCGR3B/NFKB1/TGFB1/NCF1/MAPK1/NFKBIB/ITGA4	9.72284240035726
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	63/1451	155/9376	2.62638891976612	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-B/CTSS/HLA-DQB1/HLA-DQA1/ITGB2/MSR1/HLA-DMA/FCGR3A/HLA-DMB/HLA-A/NCF2/OLR1/STX7/CD14/HLA-DQA2/CD36/CYBB/HLA-F/FCGR1A/MARCO/NCF4/TUBA4A/LAMP2/FCGR2A/HLA-DRB5/ATP6V0E1/ITGAM/ATP6AP1/HLA-DOA/ATP6V1B2/ATP6V1C1/CORO1A/ATP6V1G1/SCARB1/STX12/TLR4/TUBA1A/TLR2/M6PR/RAB5C/ATP6V0D1/TCIRG1/DYNC1LI2/ITGAV/VAMP3/FCGR3B/ATP6V0B/FCGR2B/ATP6V1F/THBS3/HGS/NCF1/RILP/CLEC7A/RAB7A/ITGB3/ITGA2/DYNC1H1/STX18	8.73616753405305
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	49/1451	112/9376	2.82701585113715	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DQB1/HLA-DQA1/HLA-DMA/HLA-DMB/LY96/HLA-DQA2/ALOX5/NFKBIA/STAT1/HLA-DRB5/BIRC3/BIRC7/CD40/HLA-DOA/IL10/IFNGR1/BCL2L1/JAK2/PIK3R5/MAP2K3/TLR4/STAT3/BAD/LAMB3/HSPA6/LAMB2/IKBKB/TLR2/RELA/TAB2/CIITA/HSPA1A/IRAK4/TNF/MAPK8/NFKB1/TGFB1/PDPK1/GNAI2/IL10RA/HSPA1B/CASP8/MAPK1/NFKBIB/SOCS1	8.32284415220796
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	63/1451	173/9376	2.35312302059971	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DQB1/HLA-DQA1/HLA-DMA/HLA-DMB/CCL5/HLA-DQA2/IL18/TLR3/ICAM1/NFKBIA/CASP1/STAT1/TRIM25/HLA-DRB5/TRADD/IFIH1/IL1B/HLA-DOA/BID/TRAF3/CXCL10/MX2/TNFSF10/PYCARD/IFNGR1/JAK2/TLR4/PRKCB/DNAJB1/CALCOCO2/IKBKB/RELA/OAS2/CIITA/TLR7/CDK6/NLRP3/IRAK4/HNRNPUL1/NXT1/TNF/PIK3R1/TICAM1/FADD/KPNA6/KPNA1/IFNAR1/IL1A/NFKB1/IRF3/CREBBP/RNASEL/PIK3CA/IKBKE/CASP8/EP300/MAPK1/NFKBIB/ADAR	7.6862646223665
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	46/1451	109/9376	2.7269772823551	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/EBI3/HLA-DQB1/HLA-DQA1/HLA-DMA/HLA-DMB/STAT5B/TGFBR1/HLA-DQA2/CD4/STAT5A/NFKBIA/STAT1/STAT6/HLA-DRB5/IL1B/IL6R/HLA-DOA/IL2RG/IL1RAP/SMAD4/IFNGR1/JAK2/IL27/AHR/STAT3/RXRA/IKBKB/RELA/NFKBIE/IL4R/MAPK8/RXRB/NFKB1/IL27RA/TGFB1/RUNX1/IL6ST/LAT/SMAD2/PPP3R1/MAPK1/NFKBIB	7.7597905859952
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	54/1451	142/9376	2.45728540782947	TYROBP/TREM2/ACP5/FCGR3A/NCF2/SQSTM1/TGFBR1/SPI1/LILRB4/FCGR1A/LCP2/OSCAR/CSF1R/NCF4/NFKBIA/JUND/FCGR2A/STAT1/SYK/IL1B/LILRB2/BTK/IFNGR1/CYLD/JUNB/LILRB1/MITF/LILRB3/LILRA2/RELB/NFKB2/IKBKB/RELA/TAB2/SIRPA/SIRPB1/MAP2K7/TNF/PIK3R1/MAPK8/IFNAR1/IL1A/FCGR3B/NFKB1/TGFB1/FCGR2B/NCF1/ITGB3/PLCG2/CSF1/PIK3CA/PPP3R1/MAPK1/SOCS1	7.48709876810601
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	70/1451	216/9376	2.09408581565715	CXCL2/CCL5/NCF2/OLR1/LY96/CD14/CXCL3/CD36/MMP9/CYBB/CCL3/IL18/ABCA1/NCF4/ICAM1/NFKBIA/CASP1/POU2F3/IL1B/CD40/BID/TRAF3/TNFSF10/PYCARD/SOD2/BCL2L1/NFE2L2/JAK2/MAP2K3/TLR4/DDIT3/STAT3/POU2F2/ATF4/BAD/VAV1/HSPA6/CASP7/RXRA/PLCB2/IKBKB/TLR2/RELA/CAMK2D/CAMK2G/TAB2/HSPA1A/NLRP3/IRAK4/MAP2K7/TNF/RAP1A/GSK3B/PIK3R1/TICAM1/MAPK8/RXRB/NFKB1/IRF3/PDPK1/MAP3K5/NCF1/HSPA1B/CALM2/PIK3CA/LYN/IKBKE/CASP8/PPP3R1/MAPK1	6.96065702837729
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	40/1451	95/9376	2.72073705974101	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DQB1/HLA-DQA1/ITGB2/HLA-DMA/ACP5/CXCL2/HLA-DMB/CCL5/CXCL3/HLA-DQA2/TNFSF13B/CCL3/CD86/IL18/CCL20/ICAM1/HLA-DRB5/IL1B/ATP6V0E1/ATP6AP1/HLA-DOA/ATP6V1B2/ATP6V1C1/ITGAL/ATP6V1G1/TLR4/TLR2/FLT1/ATP6V0D1/TCIRG1/TNF/IL1A/ATP6V0B/TGFB1/ATP6V1F/CSF1	7.2127127668237
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	67/1451	205/9376	2.11188919332336	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-B/HLA-DQB1/HLA-DQA1/HLA-DMA/CDKN1A/HLA-DMB/HLA-A/TAPBP/CD44/HLA-DQA2/VIM/TAPBPL/HLA-F/ISG15/ICAM1/NFKBIA/STAT1/HLA-DRB5/SYK/GADD45B/TRADD/RBPJ/CD58/CD40/HLA-DOA/BID/TRAF3/BTK/TNFAIP3/ITGAL/CXCL10/MAP2K3/STAT3/RELB/ENTPD1/BCL2L11/NFKB2/IKBKB/TLR2/RELA/NFKBIE/OAS2/TAB2/NEDD4/CDK6/DDB2/IRAK4/MAP2K7/TNF/PIK3R1/FADD/MAPK8/IFNAR1/NFKB1/IRF3/HES1/CIR1/PLCG2/PIK3CA/LYN/IKBKE/CASP8/NFKBIB	6.88731270986904
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	60/1451	180/9376	2.15391683896164	HLA-DRA/CD74/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-B/HLA-DQB1/HLA-DQA1/HLA-DMA/HLA-DMB/CCL5/HLA-A/TAPBP/HLA-DQA2/TAPBPL/HLA-F/TLR3/TNFRSF14/SP100/NFKBIA/STAT1/HLA-DRB5/SYK/TRADD/BIRC3/POU2F3/IFIH1/IL1B/HLA-DOA/BST2/BID/TRAF3/PILRA/IFNGR1/BCL2L1/JAK2/POU2F2/BAD/IKBKB/TLR2/RELA/OAS2/TAB2/EIF2B1/IRAK4/RHEB/TNF/DAXX/PIK3R1/TICAM1/FADD/CARD9/IFNAR1/NFKB1/IRF3/RNASEL/ITGB3/PIK3CA/IKBKE/CASP8	6.68853480327539
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	86/1451	300/9376	1.85236848150701	HSPB1/TGFBR1/DUSP2/CD14/RASA1/ANGPT2/MRAS/DUSP1/STK3/MAPKAPK3/ARRB2/MAP3K2/RRAS/CSF1R/JUND/EGFR/GADD45B/TRADD/EREG/IL1B/ELK1/RASGRP3/PDGFB/PAK2/IL1RAP/DUSP10/RAPGEF2/RAC2/MAP2K3/DDIT3/SOS2/ATF4/ARRB1/PRKCB/RASA2/RELB/HSPA6/VEGFB/STK4/NFKB2/IKBKB/RELA/DUSP4/MAP4K3/PTPRR/TAB2/FLT1/DUSP3/HSPA1A/IRAK4/RPS6KA5/MAP2K7/MAPK8IP3/TNF/RPS6KA3/DAXX/RAP1A/MEF2C/GNG12/PLA2G4C/RRAS2/ARAF/MAPK8/DUSP9/IL1A/PRKACA/NFKB1/TGFB1/PRKACB/SOS1/MAP3K5/AREG/HSPA1B/MAPKAPK2/MAP3K9/PTPN7/CSF1/TAOK3/MAP4K2/PPP3R1/MAPK1/MAP3K3/MAP3K11/ELK4/PPM1A/MKNK2	6.42037618159282
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	61/1451	187/9376	2.10784375149722	MAP1LC3B/GABARAPL2/CTSB/CXCL2/GABARAPL1/CCL5/CXCL3/CYBB/GABARAP/GBP2/GPSM3/IL18/NAMPT/NFKBIA/CASP1/STAT1/IFI16/TXN/BIRC3/IL1B/GBP3/RBCK1/TRAF3/TNFAIP3/PYCARD/BCL2L1/TLR4/GBP4/GBP5/P2RX7/MFN2/CASP4/NEK7/PLCB2/IKBKB/RELA/OAS2/TAB2/NLRP3/MAP1LC3B2/IRAK4/TAB3/TNF/PSTPIP1/TICAM1/FADD/MAPK8/CARD9/IFNAR1/NFKB1/IRF3/GSDMD/TXNIP/TRPM7/RNASEL/NAIP/IKBKE/CASP8/MAPK1/NFKBIB/CARD6	6.54764159542537
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	44/1451	119/9376	2.38921867851207	CXCL2/CCL5/CXCL3/MMP9/IRF1/CFLAR/CCL20/ICAM1/NFKBIA/TRADD/BIRC3/IL1B/BCL3/TRAF3/TNFAIP3/CXCL10/CEBPB/PTGS2/CYLD/CREB5/MAP2K3/JUNB/ATF4/CASP7/RHBDF2/IKBKB/RELA/TAB2/RHBDF1/TAB3/RPS6KA5/MAP2K7/TNF/PIK3R1/FADD/MAPK8/NFKB1/ATF6B/CREB3/MAP3K5/CSF1/PIK3CA/CASP8/MAPK1	6.52572354918542
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	30/1451	66/9376	2.93715932585678	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DQB1/HLA-DQA1/HLA-DMA/HLA-DMB/HLA-DQA2/IL18/STAT1/STAT6/HLA-DRB5/IL1B/HLA-DOA/IL2RG/IL10/IFNGR1/TLR4/STAT3/TLR2/STAT4/RELA/TNF/IL4R/IL1A/NFKB1/TLR5/TGFB1/SMAD2	6.75743968395357
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	61/1451	196/9376	2.01105500780602	HLA-B/CDKN1A/MAP1LC3B/CXCL2/HLA-A/CXCL3/ANGPT2/CD86/HLA-F/GNGT1/GNG11/TLR3/CLEC2B/ICAM1/NFKBIA/STAT1/SYK/TRADD/ZFP36/HCK/BID/PDGFB/TRAF3/IFNGR1/PTGS2/JAK2/PIK3R5/STAT3/IKBKB/RELA/RCAN1/UBC/GNGT2/ATG3/CDK6/MAP1LC3B2/MAP2K7/GSK3B/PIK3R1/GNG12/TICAM1/FADD/MAPK8/IFNAR1/NFKB1/IRF3/GNB4/CREBBP/IL6ST/BECN1/CALM2/MAPKAPK2/PLCG2/PIK3CA/LYN/IKBKE/CASP8/PPP3R1/EP300/MAPK1/GNG5	6.12070134098501
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	67/1451	224/9376	1.93275573496111	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-B/HLA-DQB1/HLA-DQA1/ITGB2/HLA-DMA/CDKN1A/HLA-DMB/HLA-A/STAT5B/TGFBR1/SPI1/HLA-DQA2/HLA-F/CD4/STAT5A/ADCY7/ICAM1/ANAPC13/NFKBIA/HLA-DRB5/ZFP36/MMP7/CD40/ELK1/CDKN2B/HLA-DOA/IL2RG/ITGAL/SMAD4/BCL2L1/CREB5/VAC14/CDKN2A/ATF4/RELB/NFKB2/IKBKB/RELA/ANAPC16/ATM/CRTC2/NRP1/TNF/POLB/PIK3R1/MAPK8/PRKACA/NFKB1/TGFB1/PRKACB/ATF6B/CREB3/TBP/CREBBP/SMAD2/KAT5/PIK3CA/PPP3R1/EP300/MAPK1/MAP3K3/ELK4/RANBP3	6.04579810804334
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	72/1451	248/9376	1.87599208554723	DYNLRB1/LY96/CD14/PTPRC/IL18/CYTH3/DYNLT1/RRAS/PFN2/NFKBIA/TUBA4A/CASP1/NCKAP1L/TRADD/TXN/BIRC3/IL1B/SNX9/MYL12B/STX10/TNFSF10/KPNA3/PYCARD/PIK3C2B/MAP2K3/TLR4/AHNAK/SKP1/MYL12A/TUBA1A/CYTH4/CASP7/ABI1/CYTH2/CASP4/IKBKB/TLR2/RELA/M6PR/RAB5C/DYNLT3/TAB2/NLRP3/DYNC1LI2/IRAK4/TAB3/MAP2K7/TNF/FADD/MAPK8/KPNA1/NFKB1/TLR5/GSDMD/ACTR1A/CYTH1/RHOB/FHOD1/RILP/ACTR3C/ANXA2/RAB7A/NAIP/DYNLRB2/EXOC2/PIK3CA/CASP8/MAPK1/ARF6/DYNC1H1/DCTN1/ARL8A	5.98215850561323
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	39/1451	105/9376	2.40007876341439	CXCL2/LY96/BCL2A1/CD14/CXCL3/TNFSF13B/CFLAR/PLAU/ICAM1/NFKBIA/TRIM25/SYK/GADD45B/TRADD/BIRC3/IL1B/CD40/TRAF3/BTK/TNFAIP3/BCL2L1/PTGS2/CYLD/TLR4/PRKCB/RELB/NFKB2/IKBKB/RELA/TAB2/IRAK4/TAB3/ATM/TNF/TICAM1/NFKB1/LAT/PLCG2/LYN	6.1731031823881
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	52/1451	163/9376	2.06141734280991	CDKN1A/STAT5B/TGFBR1/MMP9/TLR3/STAT5A/NFKBIA/STAT1/STAT6/IFIH1/ELK1/ATP6AP1/BID/TRAF3/SMAD4/CREB5/JAK2/MAP2K3/TLR4/STAT3/SOS2/ATF4/BAD/PRKCB/IKBKB/TLR2/STAT4/RELA/TAB2/DDB2/IRAK4/MAP2K7/TNF/PIK3R1/TICAM1/FADD/ARAF/MAPK8/IFNAR1/NFKB1/TGFB1/IRF3/ATF6B/CREB3/YWHAZ/SOS1/CREBBP/PIK3CA/IKBKE/CASP8/EP300/MAPK1	5.84923614478115
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	37/1451	100/9376	2.39084769124742	HLA-DRA/HLA-DRB1/HLA-DPA1/CD59/HLA-DPB1/HLA-DQB1/HLA-DQA1/HLA-DMA/HLA-DMB/CD37/CD14/CD44/HLA-DQA2/CD36/CD4/FCGR1A/CSF1R/HLA-DRB5/IL1B/ITGAM/IL6R/HLA-DOA/CD9/CD33/IL7R/ANPEP/TNF/IL4R/IL1A/ITGA3/CSF2RA/IL11RA/CD38/ITGB3/CSF1/ITGA2/ITGA4	5.98299876131064
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	38/1451	105/9376	2.3385382823012	FCER1G/LSP1/PLK3/MRAS/IRF1/RRAS/NFKBIA/CASP1/STAT1/SYK/IL1B/BCL3/IL10/PYCARD/PTGS2/CYLD/ARHGEF12/RELB/NFKB2/IKBKB/RELA/NLRP3/TNF/PIK3R1/RRAS2/MAPK8/CARD9/NFKB1/CLEC4E/CALM2/MAPKAPK2/CLEC7A/PLCG2/PIK3CA/IKBKE/CASP8/PPP3R1/MAPK1	5.90176434793633
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	65/1451	227/9376	1.8502809850111	HLA-B/CDKN1A/CCL5/HLA-A/TAPBP/CXCR4/TAPBPL/CCL3/HLA-F/GNGT1/GNG11/ADCY7/NFKBIA/EGFR/AKAP13/PTGER4/TRADD/IL1B/IL6R/ELK1/BID/PTGS2/CREB5/ARHGEF12/RAC2/BCAR1/CDKN2A/STAT3/SOS2/ATF4/PRKCB/GNAQ/PLCB2/IKBKB/RELA/GNGT2/CDK6/RHEB/TNF/ITGAV/GSK3B/PIK3R1/GNG12/FADD/PRKACA/NFKB1/ARHGEF11/IRF3/GNA13/PRKACB/ATF6B/CREB3/SOS1/GNB4/GNAI2/IL10RA/CALM2/SP1/GNA11/ITGB3/PIK3CA/CASP8/PPP3R1/MAPK1/GNG5	5.54891779230114
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	38/1451	109/9376	2.25272036368465	SPP1/CCL5/LY96/CD14/CCL3/CD86/TLR3/NFKBIA/CXCL9/STAT1/IL1B/CD40/TRAF3/CXCL10/MAP2K3/TLR4/TLR1/IRF5/IKBKB/TLR2/RELA/TAB2/TLR7/IRAK4/MAP2K7/TNF/PIK3R1/TICAM1/FADD/MAPK8/IFNAR1/NFKB1/TLR5/IRF3/PIK3CA/IKBKE/CASP8/MAPK1	5.6288219794925
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	57/1451	193/9376	1.90839263970176	CXCL2/CCL5/CXCL16/STAT5B/CXCL3/CXCR4/CCL18/CCL3/GNGT1/GNG11/ARRB2/CCL20/ADCY7/NFKBIA/FGR/CXCL9/WAS/STAT1/DOCK2/HCK/FOXO3/CXCL10/CCL7/RAC2/JAK2/PIK3R5/BCAR1/STAT3/SOS2/BAD/ARRB1/PRKCB/VAV1/GNAQ/PLCB2/IKBKB/RELA/GRK4/CCL28/GNGT2/RAP1A/GSK3B/PIK3R1/GNG12/PRKACA/NFKB1/PRKACB/SOS1/GNB4/GNAI2/NCF1/PLCG2/PIK3CA/LYN/MAPK1/NFKBIB/GNG5	5.45606678907072
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	34/1451	93/9376	2.36236040402244	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DQB1/HLA-DQA1/HLA-DMA/HLA-DMB/STAT5B/HLA-DQA2/CD4/STAT5A/NFKBIA/STAT1/STAT6/HLA-DRB5/RBPJ/MAML2/NOTCH2/HLA-DOA/IL2RG/IFNGR1/JAK2/IKBKB/STAT4/RELA/NFKBIE/IL4R/MAPK8/NFKB1/LAT/PPP3R1/MAPK1/NFKBIB	5.64948709226946
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	43/1451	133/9376	2.08913738515828	CDKN1A/GABARAPL2/GABARAPL1/TGFBR1/PLK3/HOMER3/GABARAP/FBXO32/IRS2/PRKAG2/EGFR/GADD45B/FOXO3/CDKN2B/IL10/TNFSF10/SMAD4/SOD2/BCL6/STAT3/SOS2/PRKAB2/IL7R/STK4/BCL2L11/IKBKB/SGK3/S1PR4/ATM/PIK3R1/RBL2/ARAF/MAPK8/FOXO4/FBXO25/CAT/TGFB1/PDPK1/SOS1/CREBBP/PIK3CA/EP300/MAPK1	5.41279673655162
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	24/1451	56/9376	2.76932165009353	ITGB2/CXCL2/CD14/CXCL3/IL18/NFKBIA/CASP1/IL1B/ITGAM/PYCARD/TLR4/HSPA6/CASP7/NFKB2/TLR2/RELA/HSPA1A/TNF/CLK1/NFKB1/TLR5/HSPA1B/NAIP/CASP8	5.68214821790851
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	33/1451	91/9376	2.34327216546376	DAPP1/LILRB4/PIK3AP1/NFKBIA/PTPN6/SYK/CD72/LILRB2/RASGRP3/BTK/RAC2/LILRB1/LILRB3/SOS2/PRKCB/LILRA2/VAV1/IKBKB/RELA/NFKBIE/GSK3B/PIK3R1/INPPL1/NFKB1/FCGR2B/SOS1/INPP5D/PLCG2/PIK3CA/LYN/PPP3R1/MAPK1/NFKBIB	5.50951622973006
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	44/1451	138/9376	2.06026828074591	FN1/CD4/IL18/LCP2/NFKBIA/CASP1/FCGR2A/WAS/SKAP2/IL1B/IL10/PYCARD/ARHGEF12/RAC2/MAP2K3/TLR4/BCAR1/GIT2/PIP5K1B/VAV1/GNAQ/IKBKB/RELA/TAB2/NLRP3/IRAK4/MAP2K7/TNF/RPS6KA3/GSK3B/PIK3R1/TICAM1/BAIAP2/MAPK8/NFKB1/IRF3/LAT/WIPF2/ACTR3C/PIK3CA/WIPF1/MAPK1/ARF6/ITGA4	5.36890899233253
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	68/1451	250/9376	1.75759614059269	HLA-B/CLTB/HLA-A/TGFBR1/SH3KBP1/CXCR4/SH3GLB2/DAB2/HLA-F/CYTH3/ARRB2/EGFR/AP2A2/IST1/IL2RG/ARFGAP3/EHD1/RAB31/AGAP3/SMURF2/ARAP1/ARRB1/GIT2/ARAP2/PIP5K1B/CHMP5/HSPA6/CYTH4/ACAP3/CYTH2/PDCD6IP/EHD4/RAB5C/RAB35/WWP1/GRK4/AP2M1/HSPA1A/RUFY1/NEDD4/CHMP3/RAB11FIP5/VPS35/SNX1/MVB12B/CAPZA2/STAMBP/VPS37B/CLTC/PLD1/SNX12/HGS/PIP5KL1/CYTH1/ZFYVE27/NEDD4L/SMAP2/HSPA1B/WIPF2/ACTR3C/RABEP1/SMAD2/RAB7A/FOLR2/ARFGAP1/WIPF1/VPS4B/ARF6	5.1950201293499
Human Diseases	Infectious disease: viral	hsa05162	Measles	43/1451	136/9376	2.04305347225037	STAT5B/STAT5A/NFKBIA/BBC3/STAT1/TRADD/IFIH1/IL1B/BID/IL2RG/TRAF3/TNFAIP3/MX2/BCL2L1/TLR4/STAT3/BAD/MSN/HSPA6/IKBKB/TLR2/RELA/OAS2/TAB2/TLR7/HSPA1A/CDK6/IRAK4/GSK3B/PIK3R1/FADD/MAPK8/IFNAR1/IL1A/NFKB1/IRF3/FCGR2B/HSPA1B/PIK3CA/IKBKE/CASP8/NFKBIB/ADAR	5.2427572646314
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	39/1451	120/9376	2.1000689179876	NFKBIA/FOXO3/MATK/GAB1/ARHGDIB/SOS2/ATF4/BAD/SH2B3/KIDINS220/IKBKB/RELA/CAMK2D/NFKBIE/CAMK2G/IRAK4/RPS6KA5/MAP2K7/RPS6KA3/SH2B1/RAP1A/GSK3B/PIK3R1/MAPK8/IRAK3/NFKB1/PSEN1/FRS2/PDPK1/SOS1/MAP3K5/CALM2/MAPKAPK2/PLCG2/PIK3CA/MAPK1/NFKBIB/MAP3K3/ZNF274	5.18941679522065
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	34/1451	99/9376	2.2191870462029	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DQB1/HLA-DQA1/ITGB2/HLA-DMA/FCGR3A/C1QB/HLA-DMB/C1QA/HLA-DQA2/C5AR1/FPR3/C1QC/C3AR1/FCGR1A/ICAM1/FCGR2A/CFB/HLA-DRB5/ITGAM/PTAFR/C2/HLA-DOA/IL10/ITGAL/FPR1/KRT18/SELPLG/KRT27/FCGR3B/FCGR2B	5.21799751140595
Human Diseases	Immune disease	hsa05310	Asthma	16/1451	32/9376	3.23087525844245	HLA-DRA/HLA-DRB1/HLA-DPA1/PRG2/HLA-DPB1/HLA-DQB1/FCER1G/HLA-DQA1/HLA-DMA/HLA-DMB/HLA-DQA2/HLA-DRB5/CD40/HLA-DOA/IL10/TNF	5.4088329699939
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	42/1451	137/9376	1.98097461101581	CTSS/CTSD/CTSB/CSF2RB/BCL2A1/CTSZ/CFLAR/PMAIP1/NFKBIA/TUBA4A/BBC3/GADD45B/TRADD/BIRC3/BID/NOL3/TNFSF10/BCL2L1/DDIT3/ATF4/BAD/CTSO/TUBA1A/CTSH/CASP7/BCL2L11/IKBKB/RELA/ATM/TNF/DAXX/PIK3R1/FADD/LMNA/MAPK8/NFKB1/PDPK1/MAP3K5/PARP4/PIK3CA/CASP8/MAPK1	4.94908914282472
Human Diseases	Immune disease	hsa05330	Allograft rejection	18/1451	39/9376	2.98234639240842	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-B/HLA-DQB1/HLA-DQA1/HLA-DMA/HLA-DMB/HLA-A/HLA-DQA2/CD86/HLA-F/HLA-DRB5/CD40/HLA-DOA/IL10/TNF	5.30796288980696
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	32/1451	94/9376	2.19974485681188	CXCL2/S100A7/CXCL3/MMP9/S100A9/CCL20/NFKBIA/JUND/TRADD/IL1B/S100A8/TRAF3/TNFAIP3/CXCL10/CEBPB/CCL7/PTGS2/IKBKB/RELA/IL17RE/TAB2/TAB3/TNF/GSK3B/FADD/MAPK8/NFKB1/LCN2/IKBKE/CASP8/MAPK6/MAPK1	5.00209286865189
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	82/1451	333/9376	1.59118180896265	SPP1/FN1/HLA-B/CDKN1A/HES2/HLA-A/IRF1/HLA-F/TLR3/ISG15/STAT1/EGFR/PTGER4/TRADD/RBPJ/MAML2/ATP6V0E1/NOTCH2/ATP6AP1/TRAF3/ATP6V1B2/ATP6V1C1/MX2/ATP6V1G1/PTGS2/CREB5/UBR4/SOS2/BAD/LAMB3/LAMB2/LFNG/OASL/IKBKB/RELA/ATP6V0D1/CDK6/DVL1/TCIRG1/MFNG/ATM/RHEB/TNF/ITGAV/GSK3B/PIK3R1/RBL2/TICAM1/FADD/DVL3/IFNAR1/WNT7A/PRKACA/NFKB1/ATP6V0B/IRF3/PRKACB/APC/ITGB6/ITGA3/HES1/PSEN1/FZD1/ATP6V1F/CREB3/THBS3/SOS1/TBP/CREBBP/FZD7/SCRIB/NFX1/ITGB3/PIK3CA/ITGA2/IKBKE/CASP8/EP300/MAPK1/UBE3A/ITGA4/PPP2R2D	4.70009485112505
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	34/1451	103/9376	2.13300502499113	C1QB/CCL5/C1QA/SERPINE1/TGFBR1/CCL3/CFLAR/C1QC/NFKBIA/IL1B/GNA15/IL10/IFNGR1/TLR4/GNAQ/PLCB2/IKBKB/TLR2/RELA/IRAK4/TNF/PIK3R1/TICAM1/FADD/MAPK8/NFKB1/TGFB1/GNAI2/SMAD2/GNA11/PIK3CA/CASP8/MAPK1/PPP2R2D	4.94720637392039
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	29/1451	82/9376	2.28525323158125	HLA-DRA/CD74/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-B/CTSS/HLA-DQB1/HLA-DQA1/HLA-DMA/LGMN/CTSB/HLA-DMB/HLA-A/TAPBP/HLA-DQA2/IFI30/TAPBPL/HLA-F/CD4/HLA-DRB5/HLA-DOA/HSPA6/CIITA/HSPA1A/TNF/HSPA1B/NFYA/PSME2	5.00165815075854
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	28/1451	78/9376	2.31960274965099	ITGB2/C1QB/C1QA/LY96/CD14/IRF1/C1QC/CASP1/IL1B/ITGAM/IRF8/C2/IL10/PYCARD/TLR4/CASP7/RELA/NLRP3/IRAK4/TNF/TICAM1/MAPK8/IL1A/NFKB1/IRF3/GNAI2/CALM2/MAPK1	5.00743650640835
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	43/1451	144/9376	1.9295505015698	CXCL2/C1QB/C1QA/LY96/CD14/CXCL3/C5AR1/C1QC/C3AR1/PRKAG2/NFKBIA/LPIN2/TRADD/IL1B/ACADVL/C2/FOXO3/TRAF3/MAP2K3/SREBF1/TLR4/PRKAB2/IKBKB/RELA/TAB2/IRAK4/TAB3/ADIPOR1/MAP2K7/TNF/GSK3B/CPT1A/TICAM1/FADD/MAPK8/ACOX1/LPIN1/NFKB1/ALDH3A2/IRF3/MAP3K5/IKBKE/CASP8	4.80978924226184
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	16/1451	33/9376	3.13296994758056	VAMP8/STX7/SNAP23/VAMP2/STX11/STX4/STX3/VAMP7/BET1/VAMP5/VAMP3/VAMP4/STX16/VTI1B/STX8/STX18	5.25192168014327
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	48/1451	168/9376	1.84621443339569	CSH1/CSH2/CSHL1/CDKN1A/GH2/STAT5B/CSF2RB/SOCS2/CISH/OSMR/STAT5A/OSM/PTPN6/STAT1/EGFR/STAT6/IL6R/PDGFB/IL2RG/IL10/IFNGR1/BCL2L1/JAK2/IL27/IL13RA1/STAT3/IL22RA2/SOS2/IL7R/STAT4/FHL1/LIFR/PIM1/PIAS1/IL4R/PIK3R1/IFNAR1/IL27RA/SOS1/CREBBP/IL6ST/CSF2RA/IL10RA/IL11RA/PIK3CA/EP300/SOCS1/SOCS6	4.73556850036886
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	19/1451	44/9376	2.79030135956394	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-B/HLA-DQB1/HLA-DQA1/HLA-DMA/HLA-DMB/HLA-A/HLA-DQA2/CD86/HLA-F/HLA-DRB5/IL1B/HLA-DOA/TNF/IL1A/ICA1	5.09313072857316
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	34/1451	105/9376	2.09237635784845	MAP1LC3B/GABARAPL2/GABARAPL1/SQSTM1/PINK1/MRAS/AMFR/GABARAP/RRAS/FIS1/NBR1/FOXO3/OPTN/BCL2L1/BNIP3L/SMURF2/MITF/ATF4/CALCOCO2/ULK1/MFN2/RELA/RAB5C/UBC/MAP1LC3B2/RHOT1/MUL1/RRAS2/MAPK8/TBC1D15/BECN1/SP1/RAB7A/CCZ1B	4.81640901012929
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	55/1451	204/9376	1.74213861974838	FN1/TIMP3/CDKN1A/CD44/MMP9/MRAS/PLAUR/RRAS/PLAU/GPC3/ANK3/PTPN6/EGFR/HBEGF/TWIST1/ELK1/NUDT16L1/GAB1/ARHGEF12/TLR4/PPP1R12B/STAT3/SOS2/SDC2/PRKCB/MSN/VAV1/TLR2/CAMK2D/CAMK2G/CD63/TNF/ITGAV/PIK3R1/RRAS2/ARAF/HCLS1/WNT7A/PRKACA/PPP1R12C/TGFB1/PRKACB/HPSE/FZD1/EZR/FRS2/PDPK1/SOS1/FZD7/SMAD2/ITGB3/PLCG2/PIK3CA/ITGA2/MAPK1	4.58551165731713
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	45/1451	157/9376	1.85209409719631	C1QB/C1QA/LIPA/DUSP2/CD36/GULP1/ALOX5/HAVCR2/C1QC/ABCA1/PTPN6/CASP1/PTGER4/DNMT3A/IL10/CEBPB/PTGS2/JAK2/ADAM10/NR1H3/BCAR1/CASP7/RXRA/SIGLEC10/DUSP4/RAB5C/CAMK2D/CAMK2G/CD47/SIRPA/SIRPB1/GPR132/ITGAV/CPT1A/VPS8/TGFB1/PLA2G15/P2RY2/MAPKAPK2/STAB1/RAB7A/TMEM30A/ITGB3/MAPK1/SPHK1	4.60696788138521
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	20/1451	50/9376	2.58470020675396	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DQB1/HLA-DQA1/HLA-DMA/HLA-DMB/HLA-DQA2/CXCR4/TNFSF13B/CD86/HLA-DRB5/CD40/HLA-DOA/IL10/CCL28/TGFB1/ICOSLG/ITGA4	4.80733204558155
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	37/1451	122/9376	1.95971122233395	CSH1/CSH2/CSHL1/GH2/STAT5B/SOCS2/IRS2/STAT5A/ADCY7/STAT1/CREB5/JAK2/MAP2K3/JUNB/BCAR1/STAT3/SOS2/ATF4/PRKCB/GNAQ/PLCB2/GSK3B/PIK3R1/MAPK8/PRKACA/PRKACB/ATF6B/CREB3/SOS1/CREBBP/GNAI2/GNA11/PLCG2/PIK3CA/EP300/MAPK1/SOCS1	4.56536442130046
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	25/1451	70/9376	2.30776804174461	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-B/HLA-DQB1/HLA-DQA1/ITGB2/HLA-DMA/HLA-DMB/HLA-A/HLA-DQA2/CD86/HLA-F/ICAM1/HLA-DRB5/CD40/HLA-DOA/BID/ITGAL/ABL2/RAC2/SGCE/SNTB1/CASP8	4.69913503420562
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	44/1451	156/9376	1.82254501758292	CDKN1A/CFLAR/TLR3/NFKBIA/STAT1/EGFR/TRADD/BID/YWHAG/TRAF3/CXCL10/MX2/SCARB1/CLDN9/NR1H3/STAT3/SOS2/BAD/RXRA/IKBKB/RELA/OAS2/PIAS1/CDK6/CLDN23/TNF/GSK3B/YWHAH/PIK3R1/TICAM1/FADD/ARAF/IFNAR1/NFKB1/IRF3/YWHAZ/SOS1/RNASEL/PIK3CA/IKBKE/CASP8/MAPK1/IFIT1/PPP2R2D	4.43278046934934
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	53/1451	200/9376	1.7123638869745	IL18/CYTH3/NFKBIA/PTPN6/TUBA4A/CASP1/FCGR2A/NCKAP1L/TRADD/IL1B/PAK2/TNFSF10/MYO5B/PYCARD/CLDN9/ARHGEF12/TLR4/TUBA1A/CYTH4/CASP7/ABI1/CYTH2/CASP4/IKBKB/RELA/TAB2/MYO1F/NLRP3/CLDN23/MYO5A/IRAK4/MYO1G/TAB3/TNF/FADD/BAIAP2/MAPK8/HCLS1/NFKB1/ARHGEF11/TLR5/GNA13/MYO1C/EZR/CYTH1/WIPF2/ACTR3C/NAIP/WIPF1/CASP8/MAPK1/NFKBIB/ARF6	4.35722412247436
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	35/1451	115/9376	1.96661972253019	CDKN1A/NR4A2/ARRB2/MAFB/ADCY7/JUND/EGFR/AKAP13/WNK1/HBEGF/CREB5/ATF4/ARRB1/PRKCB/GNAQ/RXRA/PLCB2/PDE4B/MEF2A/MEF2C/VDR/MEF2D/ARAF/PRKACA/RXRB/ARHGEF11/GNA13/PRKACB/ATF6B/CREB3/PLD1/GNAI2/SP1/GNA11/MAPK1	4.46267581357844
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	31/1451	98/9376	2.04402312268808	GSN/FCGR3A/MARCKS/PTPRC/FCGR1A/FCGR2A/WAS/SYK/SCIN/HCK/RAC2/PRKCB/PIP5K1B/VAV1/PIK3R1/PLA2G4C/INPPL1/FCGR3B/FCGR2B/PLD1/INPP5D/NCF1/LIMK2/LAT/ACTR3C/PLCG2/PIK3CA/LYN/MAPK1/ARF6/SPHK1	4.44544949039541
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	26/1451	77/9376	2.18188978492218	CDKN1A/TGFBR1/STAT1/EGFR/GADD45B/RALGDS/SMAD4/BCL2L1/RAC2/CDKN2A/STAT3/BAD/IKBKB/RELA/CDK6/DDB2/PIK3R1/ARAF/MAPK8/NFKB1/TGFB1/PLD1/ARHGEF6/SMAD2/PIK3CA/MAPK1	4.45578191809636
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	63/1451	253/9376	1.60905250025197	CAST/MAP1LC3B/CCL5/SQSTM1/CD14/CD44/RRAGD/IL18/CYTH3/PFN2/NFKBIA/CASP1/EGFR/TRADD/IL1B/TNIP1/MYL12B/FOXO3/RBCK1/PYCARD/BCL2L1/HK3/TLR4/BCAR1/SKP1/MYL12A/CYTH4/CALCOCO2/CYTH2/CASP4/PLCB2/IKBKB/RELA/TAB2/UBC/NLRP3/MAP1LC3B2/TAB3/RPS6KA5/ATM/TNF/UBE2D3/UBE2D4/GSK3B/PIK3R1/MAPK8/HCLS1/FOXO4/NFKB1/TLR5/IRF3/PLCD3/CYTH1/FBXW11/ACTR3C/BECN1/NAIP/RRAGB/PLCG2/PIK3CA/MAPK1/NFKBIB/ARF6	4.20209496030319
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	25/1451	73/9376	2.21292825920716	CDKN1A/STAT5B/STAT5A/EGFR/GADD45B/FOXO3/CDKN2A/STAT3/SOS2/BAD/PRKCB/STK4/RXRA/CDK6/DDB2/PIK3R1/ARAF/RXRB/RASSF5/PDPK1/SOS1/PLCG2/PIK3CA/EML4/MAPK1	4.45148324496235
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	46/1451	169/9376	1.75881966731779	VAMP8/CTSD/MAP1LC3B/GABARAPL2/CTSB/DAPK1/GABARAPL1/SQSTM1/STX7/MRAS/RRAGD/CFLAR/GABARAP/IRS2/RRAS/LAMP2/NBR1/OPTN/WDR45/BCL2L1/BAD/CALCOCO2/ULK1/ATG16L2/MTMR4/UBC/C9orf72/ATG3/MAP1LC3B2/RHEB/ATG7/PIK3R1/RRAS2/MAPK8/PRKACA/PRKACB/EPG5/PDPK1/BECN1/GORASP1/RAB7A/MTMR3/RRAGB/PIK3CA/MAPK1/EIF2AK4	4.25934254420051
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	18/1451	45/9376	2.58470020675396	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-B/HLA-DQB1/HLA-DQA1/HLA-DMA/HLA-DMB/HLA-A/HLA-DQA2/CD86/HLA-F/HLA-DRB5/IL1B/HLA-DOA/TNF/IL1A	4.55941355179073
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	55/1451	214/9376	1.66073027303117	HLA-B/HLA-A/TAPBP/SAMHD1/CXCR4/TAPBPL/HLA-F/CD4/GNGT1/GNG11/NFKBIA/AP1S2/TRADD/BST2/BID/PAK2/BCL2L1/RAC2/MAP2K3/TLR4/BAD/PRKCB/SKP1/GNAQ/IKBKB/TLR2/RELA/TAB2/GNGT2/RNF7/APOBEC3G/IRAK4/ATM/CUL5/MAP2K7/TNF/PIK3R1/GNG12/FADD/MAPK8/NFKB1/IRF3/APOBEC3A/GNB4/GNAI2/LIMK2/FBXW11/CALM2/GNA11/PLCG2/PIK3CA/CASP8/PPP3R1/MAPK1/GNG5	4.18365301288495
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	17/1451	42/9376	2.61547044731056	FTL/SAT1/MAP1LC3B/GPX4/SLC39A8/CYBB/HMOX1/SLC11A2/PRNP/ACSL4/ACSL3/ACSL1/LPCAT3/MAP1LC3B2/ATG7/ACSL5/GCLC	4.48961885792725
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	36/1451	125/9376	1.86098414886285	CTSD/FCER1G/ASAH1/SPTLC3/TRADD/BID/SGMS1/RAC2/PRKCB/CERS6/SGMS2/GNAQ/PLCB2/RELA/ORMDL1/ORMDL3/SMPD1/S1PR4/TNF/PIK3R1/MAPK8/NFKB1/NSMAF/GNA13/SGPP1/PLD1/PDPK1/MAP3K5/GNAI2/SMPD2/PIK3CA/SGPL1/MAPK1/SPHK1/PPP2R2D/ADORA3	4.14644138952677
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	25/1451	76/9376	2.12557582792267	OLR1/LPL/CYP27A1/CD36/SORBS1/FABP5/GK/ACSL4/FABP3/FABP4/ACSL3/ACSL1/NR1H3/RXRA/ANGPTL4/UBC/FABP7/CPT1A/ACOX1/RXRB/ACSL5/PDPK1/SLC27A1/CPT2/SLC27A4	4.21560381399519
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	52/1451	205/9376	1.63907817989276	HLA-B/GSN/CDKN1A/HLA-A/STAT5B/HLA-F/PMAIP1/STAT5A/SP100/NFKBIA/SYK/TRADD/RBPJ/SCIN/CDKN2B/YWHAG/TRAF3/CREB5/VAC14/UBR4/CDKN2A/STAT3/ATF4/BAD/RASA2/NFKB2/RELA/ATP6V0D1/CDK6/POLB/YWHAH/PIK3R1/RBL2/PRKACA/NFKB1/IRF3/PRKACB/ATF6B/CREB3/YWHAZ/TBP/CREBBP/SCRIB/IL6ST/MAPKAPK2/GTF2A1/PIK3CA/LYN/CASP8/EP300/MAPK1/UBE3A	3.95860603503078
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	23/1451	69/9376	2.15391683896164	FCER1G/ALOX5AP/ALOX5/LCP2/SYK/BTK/RAC2/MAP2K3/SOS2/VAV1/MAP2K7/TNF/PIK3R1/PLA2G4C/MAPK8/PDPK1/SOS1/INPP5D/LAT/PLCG2/PIK3CA/LYN/MAPK1	4.11636529853359
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	26/1451	83/9376	2.02416281251816	CCL5/SAMHD1/IL18/NFKBIA/CASP1/IFI16/TREX1/IL1B/CXCL10/PYCARD/CASP7/ZDHHC1/IKBKB/RELA/ZCCHC3/NLRP3/FADD/POLR3D/NFKB1/IRF3/GSDMD/DNASE2/IKBKE/CASP8/NFKBIB/ADAR	4.01005001250366
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	23/1451	70/9376	2.12314659840504	CD36/IRS2/PRKAG2/NFKBIA/TRADD/ACSL4/ACSL3/ACSL1/JAK2/STAT3/PRKAB2/RXRA/IKBKB/RELA/NFKBIE/ADIPOR1/TNF/CPT1A/MAPK8/RXRB/NFKB1/ACSL5/NFKBIB	4.03574438328773
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	33/1451	116/9376	1.83825661256209	ITGB2/NCF2/CXCR4/ESAM/MMP9/CYBB/NCF4/ICAM1/ITGAM/MYL12B/SIPA1/ITGAL/CLDN9/RAC2/BCAR1/CD99/PRKCB/MSN/VAV1/MYL12A/TXK/CLDN23/RAP1A/PIK3R1/CD99L2/ARHGAP5/RASSF5/EZR/GNAI2/NCF1/PLCG2/PIK3CA/ITGA4	3.88705063712189
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	23/1451	71/9376	2.09324312518807	CXCL2/CCL5/CXCL3/NFKBIA/EGFR/HBEGF/ATP6V0E1/ATP6AP1/ATP6V1B2/ATP6V1C1/ATP6V1G1/ADAM10/IKBKB/RELA/ATP6V0D1/TCIRG1/MAPK8/NFKB1/ATP6V0B/ATP6V1F/PLCG2/LYN/CSK	3.95646610591002
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	50/1451	201/9376	1.60740062609077	CDKN1A/HPGD/BCL2A1/SPI1/CD14/MMP9/AFF1/CD86/FUT8/FCGR1A/KLF3/CSF1R/PLAU/NUPR1/GADD45B/BIRC3/ITGAM/NR4A3/CD40/JMJD1C/CEBPB/BCL2L1/PBX3/BMI1/BCL6/DDIT3/MITF/PER2/CDK9/LYL1/RXRA/RELA/ETV6/FLT1/FLI1/ARNT2/DDB2/BMP2K/ATM/SUPT3H/MEF2C/RXRB/NFKB1/NCOR1/RUNX1/HHEX/PTCRA/SP1/ELK4/DOT1L	3.72468831482267
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	22/1451	68/9376	2.09056634369806	STAT5B/BCL2A1/SPI1/CD14/FCGR1A/STAT5A/CSF1R/ITGAM/PER2/STAT3/SOS2/BAD/IKBKB/RELA/PIM1/PIK3R1/ARAF/NFKB1/RUNX1/SOS1/PIK3CA/MAPK1	3.8618737206084
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	31/1451	109/9376	1.837745559848	CD36/IRS2/PRKAG2/NFKBIA/CREB5/NR1H3/SREBF1/STAT3/PRKCB/PRKAB2/IKBKB/RELA/MLXIP/CRTC2/TNF/RPS6KA3/GSK3B/CPT1A/PIK3R1/MAPK8/NFKB1/CREB3/PDPK1/TRIB3/SLC27A1/PIK3CA/SLC27A4/PYGB/PTPN1/PPP1R3D/PPP1R3E	3.76422444880264
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	24/1451	77/9376	2.01405210915893	CDKN1A/STAT5B/TGFBR1/STAT5A/NFKBIA/GADD45B/BCR/SMAD4/BCL2L1/CDKN2A/SOS2/BAD/IKBKB/RELA/CDK6/DDB2/PIK3R1/ARAF/NFKB1/TGFB1/RUNX1/SOS1/PIK3CA/MAPK1	3.82302572510631
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	41/1451	160/9376	1.65582356995176	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-B/HLA-DQB1/HLA-DQA1/ITGB2/HLA-DMA/HLA-DMB/HLA-A/HLA-DQA2/ESAM/PTPRC/ALCAM/CD86/HLA-F/CD4/ICAM1/HLA-DRB5/GLG1/ITGAM/CD58/CD40/HLA-DOA/SIGLEC1/ITGAL/CLDN9/SPN/CD99/SDC2/SELPLG/CLDN23/ITGAV/CD99L2/MAG/ICOSLG/ICAM2/CADM1/NLGN4X/ITGA4	3.58010272516946
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	55/1451	232/9376	1.5318805104684	FN1/GSN/ITGB2/RGCC/TMSB4X/IQGAP2/CXCR4/MRAS/RRAS/PFN2/ITGAX/NCKAP1L/EGFR/SCIN/ITGAM/MYL12B/PDGFB/PAK2/ITGAL/ARHGEF12/RAC2/PPP1R12B/BCAR1/SOS2/MSN/PIP5K1B/VAV1/MYL12A/DIAPH2/FGD3/ITGAV/PIK3R1/GNG12/RRAS2/ARAF/PIP4K2A/BAIAP2/SSH3/PPP1R12C/GNA13/APC/ITGB6/ITGA3/EZR/SOS1/ARHGEF6/MYLK/LIMK2/ACTR3C/ITGB3/PIK3CA/ITGA2/MAPK1/ITGA4/SPATA13	3.51002063484586
Organismal Systems	Immune system	hsa04611	Platelet activation	34/1451	126/9376	1.7436469648737	VAMP8/FCER1G/FERMT3/SNAP23/LCP2/ADCY7/FCGR2A/TBXAS1/SYK/MYL12B/BTK/ORAI1/ARHGEF12/APBB1IP/PTGS1/PIK3R5/MYL12A/GNAQ/PLCB2/RAP1A/PIK3R1/PLA2G4C/PRKG1/PRKACA/GNA13/PRKACB/MYLK/GNAI2/ITGB3/PLCG2/PIK3CA/ITGA2/LYN/MAPK1	3.59584468405595
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	56/1451	238/9376	1.52041188632586	RASA1/ANGPT2/MRAS/GNGT1/GNG11/RRAS/CSF1R/EGFR/ELK1/RALGDS/RASGRP3/PDGFB/RALGAPA2/PAK2/ABL2/GAB1/BCL2L1/RAC2/SOS2/BAD/PRKCB/RASA2/VEGFB/STK4/RASAL2/IKBKB/RELA/RAB5C/FLT1/PLA2G2F/GNGT2/RAP1A/PIK3R1/GNG12/PLA2G4C/RRAS2/MAPK8/FOXO4/PRKACA/RALGAPB/NFKB1/RASSF5/PRKACB/PLD1/SOS1/GNB4/LAT/CALM2/PLA2G12A/PLCG2/EXOC2/CSF1/PIK3CA/MAPK1/ARF6/GNG5	3.47960397285666
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	29/1451	103/9376	1.81932781543361	FN1/HSPB1/ITGB2/CXCL2/CD14/CXCL3/IL1B/ITGAM/GNA15/IL10/TLR4/PRKCB/LAMB3/LAMB2/GNAQ/PLCB2/TLR2/RELA/RAB5C/TNF/PIK3R1/PRKACA/NFKB1/TGFB1/PRKACB/PRDX1/GNA11/RAB7A/PIK3CA	3.57755146838397
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	20/1451	62/9376	2.08443565060803	RBPJ/MAML2/NOTCH2/TLE2/ATXN1/LFNG/DVL1/MFNG/DVL3/TLE6/DTX3L/HES1/PSEN1/CIR1/ATXN1L/PTCRA/CREBBP/APH1B/EP300/NCSTN	3.66565192178969
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	42/1451	168/9376	1.61543762922123	FTL/GLUL/SQSTM1/STAT5B/CYBB/CFLAR/TLR3/STAT5A/CASP1/STAT1/STAT6/TRADD/BIRC3/IL1B/RBCK1/BID/TNFAIP3/TNFSF10/PYCARD/IFNGR1/CYLD/JAK2/TLR4/STAT3/CHMP5/STAT4/CAMK2D/CAMK2G/SMPD1/NLRP3/CHMP3/TNF/PLA2G4C/TICAM1/FADD/MAPK8/IFNAR1/IL1A/TRPM7/PYGB/CASP8/VPS4B	3.44409990643464
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	22/1451	72/9376	1.97442376904817	ISG15/NFKBIA/TRIM25/TRADD/IFIH1/TRAF3/CXCL10/CYLD/IKBKB/RELA/ZNFX1/TNF/FADD/MAPK8/NFKB1/IRF3/RNF125/OTUD5/IKBKE/CASP8/NFKBIB/ADAR	3.55139497176508
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	25/1451	86/9376	1.87841584793166	CDKN1A/STAT5B/STAT5A/EGFR/EREG/HBEGF/ELK1/PAK2/ABL2/GAB1/SOS2/BAD/PRKCB/CAMK2D/CAMK2G/MAP2K7/GSK3B/PIK3R1/ARAF/MAPK8/SOS1/AREG/PLCG2/PIK3CA/MAPK1	3.50155732011158
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	42/1451	170/9376	1.59643248064215	CDKN1A/TGFBR1/HMOX1/EGFR/GADD45B/GSTT1/ELK1/SMAD4/GSTA3/GAB1/BCL2L1/NFE2L2/CDKN2A/SOS2/BAD/PRKCB/TXNRD1/BRD7/CDK6/DVL1/DDB2/FRAT1/GSK3B/PIK3R1/SMARCC2/ARAF/DVL3/WNT7A/TXNRD2/TGFB1/APC/FZD1/SOS1/FZD7/FRAT2/SMAD2/PLCG2/PIK3CA/ARID1B/NQO1/GSTM3/MAPK1	3.35791710464925
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	34/1451	130/9376	1.68999628903144	TGFBR1/MMP9/GNGT1/GNG11/ARRB2/ADCY7/NFKBIA/EGFR/GNA15/CREB5/SOS2/ATF4/ARRB1/VEGFB/PLCB2/RELA/GNGT2/MAP2K7/PIK3R1/GNG12/MAPK8/PRKACA/NFKB1/TGFB1/PRKACB/ATF6B/CREB3/SOS1/GNB4/GNAI2/SMAD2/PIK3CA/MAPK1/GNG5	3.38969947093766
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	18/1451	55/9376	2.11475471461688	HEXB/ASAH1/SPTLC3/ACER3/PSAP/SGMS1/CERS6/SGMS2/HEXA/UGCG/ARSA/GALC/B4GALT5/SMPD1/SGPP1/SMPD2/SGPL1/SPHK1	3.54771821287902
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	28/1451	101/9376	1.79137638091859	FN1/SERPINE1/STAT5B/TGFBR1/CYBB/STAT5A/ICAM1/STAT1/IL1B/SMAD4/JAK2/STAT3/PRKCB/VEGFB/PLCB2/RELA/PIM1/TNF/PIK3R1/MAPK8/IL1A/NFKB1/TGFB1/PLCD3/SMAD2/PLCG2/PIK3CA/MAPK1	3.42142103475366
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	25/1451	87/9376	1.85682486117382	CDKN1A/TGFBR1/PMAIP1/BBC3/EGFR/GADD45B/EREG/RALGDS/SMAD4/RAC2/SOS2/BAD/BCL2L11/DDB2/GSK3B/PIK3R1/ARAF/MAPK8/TGFB1/APC/SOS1/AREG/SMAD2/PIK3CA/MAPK1	3.43547595389608
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	34/1451	133/9376	1.65187607198562	TYROBP/HLA-B/FCER1G/ITGB2/FCGR3A/HLA-A/CD48/HCST/LCP2/ICAM1/PTPN6/SH3BP2/SYK/LAT2/BID/ITGAL/TNFSF10/IFNGR1/RAC2/SOS2/PRKCB/VAV1/TNF/PIK3R1/ARAF/IFNAR1/FCGR3B/SOS1/LAT/PLCG2/PIK3CA/ICAM2/PPP3R1/MAPK1	3.23969475583381
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	21/1451	71/9376	1.91122198386737	STAT5B/IRF1/SOCS2/CISH/STAT5A/STAT1/FOXO3/JAK2/GALT/STAT3/SOS2/RELA/GSK3B/PIK3R1/MAPK8/NFKB1/SOS1/PIK3CA/MAPK1/SOCS1/SOCS6	3.29772839276819
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	25/1451	90/9376	1.7949306991347	CD4/NFKBIA/PTPN6/STAT1/EGFR/IFNGR1/JAK2/MAP2K3/TLR4/STAT3/BATF/IKBKB/TLR2/RELA/NFKBIE/PIK3R1/TICAM1/NFKB1/LAT/PIK3CA/EML4/PPP3R1/MAPK1/NFKBIB/MAP3K3	3.24232013420218
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	12/1451	32/9376	2.42315644383184	PMAIP1/BBC3/BIRC3/BIRC7/BID/BCL2L1/CASP7/BCL2L11/FADD/MAPK8/BECN1/CASP8	3.45049122120402
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	35/1451	140/9376	1.61543762922123	SPP1/MAP1LC3B/SERPINE1/TGFBR1/MRAS/GNGT1/GNG11/RRAS/ADCY7/PRKAG2/SMAD4/SLC8A1/PIK3R5/PRKAB2/GNAQ/PLCB2/MEF2A/GNGT2/MAP1LC3B2/MEF2C/GNG12/MEF2D/RRAS2/PRKACA/GNA13/PRKACB/GNB4/MYLK/GNAI2/BECN1/CALM2/SMAD2/MAPK1/SPHK1/GNG5	3.13924933655566
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	17/1451	54/9376	2.03425479235266	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-B/HLA-DQB1/HLA-DQA1/HLA-DMA/HLA-DMB/HLA-A/HLA-DQA2/CD86/HLA-F/HLA-DRB5/CD40/HLA-DOA/IL10	3.26129122192058
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	38/1451	157/9376	1.56399057096577	HLA-B/CDKN1A/SERPINE1/HLA-A/SQSTM1/TGFBR1/MRAS/HLA-F/RRAS/GADD45B/ZFP36L2/RAD50/FOXO3/CDKN2B/HIPK3/MAP2K3/CDKN2A/RELA/CDK6/ATM/RHEB/PIK3R1/RBL2/HIPK1/RRAS2/HIPK2/IL1A/NFKB1/TGFB1/RASSF5/TRPM7/FBXW11/CALM2/SMAD2/MAPKAPK2/PIK3CA/PPP3R1/MAPK1	3.04929520623685
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	21/1451	73/9376	1.85885973773401	SAMHD1/CXCR4/ELL2/CD4/BST2/MX2/MDFIC/SERINC3/CDK9/FURIN/PDCD6IP/APOBEC3G/SUPT4H1/ELL/APOBEC3A/AFF4/HGS/CREBBP/EP300/VPS4B/SUPT5H	3.15204110653237
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	34/1451	138/9376	1.5920254896673	FBP1/RHOQ/SOCS2/IRS2/SORBS1/PRKAG2/TRIP10/ELK1/HK3/SREBF1/SOS2/BAD/PRKAB2/FLOT1/IKBKB/RHEB/GSK3B/PIK3R1/ARAF/MAPK8/INPPL1/PRKACA/PRKACB/PDPK1/SOS1/CALM2/PIK3CA/PYGB/PTPN1/MAPK1/SOCS1/PPP1R3D/PPP1R3E/MKNK2	2.99785538517542
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	27/1451	104/9376	1.67756984572974	GDPD5/LPIN2/CDS1/PLD3/SGMS1/PISD/CEPT1/CDIPT/GPCPD1/LPCAT3/SGMS2/PLA2G2F/DGKZ/LPCAT2/PLA2G4C/LPIN1/CHKB/PLA2G15/DGKA/PLD1/ADPRM/MBOAT7/AGPAT2/GPD2/AGPAT3/PLA2G12A/DGKH	2.97306043373534
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	21/1451	75/9376	1.80929014472777	CDKN1A/PMAIP1/BBC3/BIRC3/GSTT1/BID/GSTA3/BCL2L1/CDKN2A/BAD/ATM/PIK3R1/FADD/PDPK1/MAP3K5/PIK3CA/GSTM3/CASP8/MAPK1/ATP7A/ERCC1	3.01085451065465
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	8/1451	19/9376	2.72073705974101	HEXB/GNS/NAGLU/HGSNAT/IDS/HEXA/HPSE/GUSB	3.21249682397431
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	34/1451	142/9376	1.54717970122596	NCF2/SQSTM1/MMP9/DUSP1/HMOX1/ICAM1/TXN/IL1B/GSTT1/PDGFB/BMPR2/GSTA3/NFE2L2/RAC2/SDC2/IKBKB/RELA/MEF2A/MAP2K7/TNF/ITGAV/MEF2C/PIK3R1/MAPK8/IL1A/NFKB1/SUMO3/MAP3K5/NCF1/CALM2/ITGB3/PIK3CA/NQO1/GSTM3	2.8112464757905
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	74/1451	362/9376	1.32091032665603	SPP1/CSH1/CSH2/FN1/CSHL1/CDKN1A/GH2/ANGPT2/GNGT1/GNG11/PIK3AP1/OSMR/CSF1R/OSM/EGFR/SYK/EREG/IL6R/FOXO3/YWHAG/PDGFB/IL2RG/BCL2L1/CREB5/JAK2/PIK3R5/TLR4/SOS2/ATF4/BAD/LAMB3/IL7R/VEGFB/LAMB2/BCL2L11/RXRA/IKBKB/SGK3/TLR2/RELA/FLT1/GNGT2/CDK6/CRTC2/RHEB/ITGAV/IL4R/GSK3B/YWHAH/PIK3R1/GNG12/RBL2/IFNAR1/NFKB1/ITGB6/ITGA3/ATF6B/CREB3/THBS3/PDPK1/YWHAZ/SOS1/GNB4/TCL1B/AREG/ITGB3/LPAR6/CSF1/PIK3CA/ITGA2/MAPK1/ITGA4/PPP2R2D/GNG5	2.66439684036527
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	35/1451	149/9376	1.51786085967095	FCER1G/MRAS/CYTH3/RRAS/ADCY7/EGFR/SYK/RALGDS/PDGFB/GAB1/PIK3R5/SOS2/PIP5K1B/CYTH4/CYTH2/PLCB2/DGKZ/RHEB/PIK3R1/PLA2G4C/RRAS2/GNA13/DGKA/PLD1/SOS1/CYTH1/AGPAT2/AGPAT3/PLCG2/LPAR6/PIK3CA/MAPK1/ARF6/SPHK1/DGKH	2.72643828039822
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	21/1451	78/9376	1.73970206223824	PIK3C2B/MTM1/CDIPT/IMPA2/PIP5K1B/MTMR1/PLCB2/ITPK1/MTMR4/MINPP1/OCRL/PIP4K2A/INPPL1/ITPKC/PLCD3/PIP5KL1/FIG4/INPP5D/MTMR3/PLCG2/PIK3CA	2.80691375589886
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	24/1451	93/9376	1.66754852048643	MAP3K2/ADCY7/EGFR/HBEGF/ELK1/MAP2K3/SOS2/ATF4/PRKCB/GNAQ/PLCB2/CAMK2D/CAMK2G/MAP2K7/PLA2G4C/MAPK8/PRKACA/PRKACB/PLD1/SOS1/CALM2/GNA11/MAPK1/MAP3K3	2.76821517919683
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	24/1451	93/9376	1.66754852048643	FN1/CDKN1A/NFKBIA/GADD45B/BIRC3/BIRC7/CDKN2B/TRAF3/BCL2L1/PTGS2/LAMB3/LAMB2/RXRA/IKBKB/RELA/CDK6/DDB2/ITGAV/PIK3R1/RXRB/NFKB1/ITGA3/PIK3CA/ITGA2	2.76821517919683
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	25/1451	98/9376	1.64840574410329	CDS1/PIK3C2B/MTM1/CDIPT/PRKCB/IMPA2/PIP5K1B/MTMR1/PLCB2/ITPK1/MTMR4/OCRL/DGKZ/PIK3R1/PIP4K2A/INPPL1/ITPKC/PLCD3/DGKA/INPP5D/CALM2/MTMR3/PLCG2/PIK3CA/DGKH	2.76091105843698
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	25/1451	99/9376	1.63175518103154	WAS/EGFR/RALGDS/PDGFB/RAC2/SLC22A5/GPCPD1/SOS2/PRKCB/PIP5K1B/DGKZ/RHEB/PIK3R1/PLA2G4C/SLC44A2/MAPK8/CHKB/DGKA/PLD1/PDPK1/SOS1/SP1/PIK3CA/MAPK1/DGKH	2.70384841498045
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	27/1451	110/9376	1.58606603596266	CDKN1A/SERPINE1/EPAS1/ANGPT2/CYBB/HMOX1/EGFR/IL6R/IFNGR1/HK3/TLR4/STAT3/PRKCB/EGLN2/RELA/CAMK2D/CAMK2G/FLT1/PFKFB3/PIK3R1/NFKB1/CREBBP/PLCG2/PIK3CA/EP300/MAPK1/MKNK2	2.64555294395964
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	23/1451	90/9376	1.65133624320392	IRS2/ADCY7/PRKAG2/FOXO3/SOD2/CREB5/ATF4/PRKAB2/ULK1/RELA/SESN3/ADIPOR1/RHEB/PIK3R1/PRKACA/NFKB1/CAT/PRKACB/ATF6B/CREB3/SESN1/PIK3CA/EHMT2	2.65663487115855
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	33/1451	142/9376	1.50167441589579	ANAPC13/HERC1/BIRC3/BIRC7/UBE2Q1/STUB1/SMURF2/SKP1/UBE2J1/UBE2E2/UBE2L6/WWP1/UBC/RNF7/ANAPC16/PIAS1/NEDD4/DDB2/CUL5/UBE2D3/UBE2D4/SYVN1/UBA7/NEDD4L/KLHL9/UBE2R2/FBXW11/UBA3/WWP2/UBE2B/SOCS1/UBE3A/FBXW8	2.57745386117473
Human Diseases	Cancer: specific types	hsa05214	Glioma	20/1451	76/9376	1.70046066233813	CDKN1A/EGFR/GADD45B/PDGFB/CDKN2A/CAMK1/SOS2/PRKCB/CAMK2D/CAMK2G/CAMK1D/CDK6/DDB2/PIK3R1/ARAF/SOS1/CALM2/PLCG2/PIK3CA/MAPK1	2.62342577590349
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	15/1451	52/9376	1.86396649525526	APOE/APOC1/LIPA/LPL/CYP27A1/CD36/ABCA1/MYLIP/NCEH1/SCARB1/APOC2/ANGPTL4/STARD3/NPC1/SOAT1	2.67311196088298
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	11/1451	34/9376	2.09056634369806	PRKAG2/NR1D2/PER2/SKP1/PRKAB2/FBXL3/NPAS2/DBP/CRY1/FBXW11/CLOCK	2.72578330162096
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	61/1451	298/9376	1.3227073205704	CSH1/CSH2/CSHL1/EBI3/TNFRSF12A/INHBA/CXCL2/GH2/CCL5/CXCL16/TGFBR1/CSF2RB/CXCL3/CXCR4/TNFSF13B/CCL18/CCL3/CD4/IL1RN/IL18/OSMR/TNFRSF14/CCL20/CSF1R/OSM/CXCL9/IL32/IL1B/TNFSF12/CD40/IL6R/IL2RG/ACKR3/BMPR2/IL1RAP/IL10/CXCL10/TNFSF10/IFNGR1/CCL7/IL27/IL13RA1/RELL2/IL7R/GDF15/IL17RE/CCL28/LIFR/TNF/IL16/IL4R/IFNAR1/IL1A/IL27RA/TGFB1/INHA/IL6ST/CSF2RA/IL10RA/IL11RA/CSF1	2.42237607931849
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	16/1451	59/9376	1.75233912322303	CDKN1A/EGFR/GADD45B/ELK1/FOXO3/SOS2/BAD/DDB2/GSK3B/PIK3R1/ARAF/APC/PDPK1/SOS1/PIK3CA/MAPK1	2.48039766413522
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	14/1451	50/9376	1.80929014472777	ITGB2/CD36/IL18/ICAM1/IL1B/CD40/IL10/ITGAL/TLR4/SDC2/TLR2/TNF/TGFB1/THBS3	2.45505517721384
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	43/1451	203/9376	1.36874518337956	SPP1/FN1/PARVG/EGFR/BIRC3/MYL12B/ELK1/PDGFB/PAK2/RAC2/ZYX/PPP1R12B/BCAR1/SOS2/BAD/PRKCB/PIP5K1B/VAV1/LAMB3/VEGFB/MYL12A/LAMB2/FLT1/PARVB/ITGAV/RAP1A/GSK3B/PIK3R1/MAPK8/ARHGAP5/PPP1R12C/ITGB6/ITGA3/EMP1/THBS3/PDPK1/SOS1/MYLK/ITGB3/PIK3CA/ITGA2/MAPK1/ITGA4	2.27268050900373
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	18/1451	70/9376	1.66159299005612	CDKN1A/EPAS1/PDGFB/PAK2/GAB1/SOS2/BAD/EGLN2/ARNT2/RAP1A/PIK3R1/ARAF/TGFB1/SOS1/CREBBP/PIK3CA/EP300/MAPK1	2.37726775599299
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	25/1451	106/9376	1.52399776341625	CDKN1A/MMP9/PLAU/NFKBIA/EGFR/PDGFB/CREB5/SOS2/ATF4/BAD/IKBKB/RELA/GSK3B/PIK3R1/ARAF/NFKB1/CREB3/PDPK1/SOS1/CREBBP/PIK3CA/FOLR2/EP300/MAPK1/SLC46A1	2.32146536075555
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	28/1451	122/9376	1.48302470879326	STAT1/NOTCH2/MED13L/SLC16A10/BAD/PRKCB/RXRA/PLCB2/RCAN1/ATP1B1/MED12/RHEB/ITGAV/GSK3B/PIK3R1/PRKACA/RXRB/PRKACB/NCOR1/PLCD3/NCOA3/PDPK1/CREBBP/ITGB3/PLCG2/PIK3CA/EP300/MAPK1	2.29775766794819
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	49/1451	238/9376	1.33036040053513	RPS4Y1/C1QB/C1QA/C5AR1/CYBB/C1QC/C3AR1/TLR3/ISG15/NFKBIA/CASP1/FCGR2A/STAT1/CFB/EGFR/SYK/HBEGF/IFIH1/IL1B/IL6R/C2/TRAF3/CXCL10/MX2/TLR4/STAT3/PRKCB/IKBKB/TLR2/RELA/OAS2/TAB2/TLR7/NLRP3/IRAK4/NRP1/TNF/PIK3R1/MAPK8/IFNAR1/NFKB1/IRF3/IL6ST/PLCG2/PIK3CA/IKBKE/MAPK1/NFKBIB/ADAR	2.20887222675149
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	34/1451	155/9376	1.41741624241346	CDKN1A/HSD3B1/CRH/ADCY7/EGFR/CDKN2B/NCEH1/ORAI1/SCARB1/CREB5/AHR/CDKN2A/ATF4/GNAQ/PLCB2/CAMK2D/CAMK2G/CDK6/DVL1/RAP1A/GSK3B/DVL3/WNT7A/PRKACA/PRKACB/APC/ATF6B/FZD1/CREB3/FZD7/GNAI2/SP1/GNA11/MAPK1	2.24215633840109
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	16/1451	62/9376	1.66754852048643	CRYAB/SOD1/IRS2/ADCY7/PRKAG2/FOXO3/SOD2/PRKAB2/HSPA6/HSPA1A/PIK3R1/PRKACA/CAT/PRKACB/HSPA1B/PIK3CA	2.25647369268699
NA	NA	hsa04517	IgSF CAM signaling	59/1451	299/9376	1.27506113878331	ITGB2/CD84/ESAM/CD48/RASA1/CD86/GLDN/SORBS1/LCP2/ITGAX/ICAM1/ANK3/PTPN6/TUBA4A/MBP/ITGAM/MYL12B/DOK2/SLAMF7/PAK2/IL1RAP/ITGAL/RAPGEF2/CABLES1/BCAR1/TJP2/PRKCB/MSN/VAV1/MYL12A/TUBA1A/CRTAM/LMO7/DOK1/NRP1/RAP1A/GSK3B/PIK3R1/MAG/BAIAP2/MAPK8/EZR/PLXNA2/PDPK1/MYLK/INPP5D/NRP2/ACTR3C/ITGB3/PLCG2/PIK3CA/ICAM2/CADM1/LYN/NLGN4X/MAPK1/CSK/ARF6/ITGA4	2.06829923870093
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	12/1451	43/9376	1.80327921401439	ACAA2/ACADVL/ACSL4/ACSL3/ACSL1/CPT1A/ECI1/ACOX1/ALDH3A2/ACSL5/CPT2/ACADS	2.25896672107501
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	23/1451	100/9376	1.48620261888353	CXCL2/CCL5/CXCL3/CXCR4/CCL18/CCL3/IL18/TNFRSF14/CCL20/CSF1R/CXCL9/IL6R/IL2RG/ACKR3/IL10/CXCL10/TNFSF10/CCL7/CCL28/TNF/IL6ST/IL10RA/CSF1	2.09149404699891
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	46/1451	227/9376	1.3094296201617	MT-ND2/MT-ND4L/NCF2/MT-ND3/MT-ND5/MT-ND1/MT-ATP6/MT-ND4/SOD1/HMOX1/COX4I1/NFKBIA/EGFR/GSTT1/FOXO3/CBR1/GSTA3/ABL2/PTPRJ/SOD2/NFE2L2/AHR/SOS2/BAD/MT-ATP8/MT-CYB/IKBKB/RELA/MAP2K7/NDUFA13/PIK3R1/ARAF/MAPK8/NFKB1/CAT/PLD1/PDPK1/SOS1/MAP3K5/NCF1/NDUFB10/PIK3CA/NQO1/GSTM3/PTPN1/MAPK1	2.01933190915451
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	12/1451	44/9376	1.76229559551407	AQP3/VAMP2/STX4/CREB5/ARHGDIB/RAB5C/DYNC1LI2/PRKACA/PRKACB/CREB3/DYNC1H1/DCTN1	2.16861317846193
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	15/1451	59/9376	1.64281792802159	UCK2/UPP1/NT5E/CDA/NME3/DPYD/ENTPD4/ENTPD1/TK2/RRM2B/TYMP/NT5C2/CMPK2/AK9/UCKL1	2.11931566219549
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	9/1451	30/9376	1.93852515506547	IL1B/ABCC3/IKBKB/RELA/MTHFR/TNF/NFKB1/FOLR2/SLC46A1	2.20299425906443
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	19/1451	80/9376	1.53466574776017	EGFR/IL6R/FOXO3/PDGFB/GAB1/BCL2L1/JAK2/STAT3/SOS2/BAD/PRKCB/BCL2L11/GSK3B/PIK3R1/ARAF/SOS1/PLCG2/PIK3CA/MAPK1	2.05493934644651
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	18/1451	75/9376	1.55082012405238	CDKN1A/SERPINE1/PMAIP1/BBC3/GADD45B/BID/CD82/BCL2L1/PPM1D/CDKN2A/RRM2B/SESN3/CDK6/DDB2/ATM/SESN1/ZNF385A/CASP8	2.04925176201214
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	36/1451	174/9376	1.33691390004515	CRYAB/DERL3/MAN1C1/AMFR/BCAP29/DNAJB2/DNAJC1/MAN1A1/STUB1/NFE2L2/DDIT3/ATF4/SKP1/HSPA6/UBE2J1/DNAJB1/MBTPS1/UBQLN4/HSPA1A/MAP2K7/UBE2D3/UBE2D4/FBXO6/MAPK8/SYVN1/ATF6B/SEL1L/SVIP/MAP3K5/UBQLN2/DNAJC5/RAD23A/SEC31A/HSPA1B/UBXN2A/DNAJB12	1.91942942229312
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	33/1451	158/9376	1.3496061206152	RRAGD/LPIN2/ATP6V1B2/ATP6V1C1/ATP6V1G1/FNIP2/CAB39/SOS2/PRKCB/ULK1/IKBKB/LAMTOR5/DVL1/RHEB/TNF/RPS6KA3/WDR59/GSK3B/PIK3R1/MAPKAP1/DVL3/WNT7A/LPIN1/FZD1/ATP6V1F/PDPK1/SOS1/FZD7/RRAGB/PIK3CA/FNIP1/MAPK1/LAMTOR2	1.89630822109317
Organismal Systems	Digestive system	hsa04978	Mineral absorption	15/1451	61/9376	1.58895504513563	FTL/TRPV6/HMOX1/SLC11A2/MT1E/SLC30A1/SLC8A1/MT2A/ATOX1/ATP1B1/HMOX2/VDR/TRPM7/ATP7A/SLC46A1	1.97458277084251
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	22/1451	98/9376	1.4505970548109	HSD3B1/NR4A2/ADCY7/DAGLB/ORAI1/SCARB1/CREB5/CAMK1/ATF4/PRKCB/GNAQ/PLCB2/CAMK2D/CAMK2G/ATP1B1/CAMK1D/PRKACA/PRKACB/ATF6B/CREB3/CALM2/GNA11	1.91864184245777
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	13/1451	51/9376	1.64711287685302	ATP6V0E1/ATP6AP1/ATP6V1B2/ATP6V1C1/ATP6V1G1/TJP2/ATP6V0D1/TCIRG1/PRKACA/ATP6V0B/PRKACB/ATP6V1F/PLCG2	1.98271557742178
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	25/1451	115/9376	1.40472837323585	GNGT1/GNG11/ADCY7/KCNJ2/CREB5/JAK2/PIK3R5/ATF4/PRKCB/GNAQ/PLCB2/CAMK2D/CAMK2G/GNGT2/PIK3R1/GNG12/PRKACA/PRKACB/CREB3/GNB4/GNAI2/GNA11/PIK3CA/MAPK1/GNG5	1.86854404085694
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	16/1451	67/9376	1.54310460104714	ATF4/PRKCB/GNAQ/PLCB2/CAMK2D/CAMK2G/RPS6KA3/RAP1A/ARAF/PRKACA/PRKACB/CREBBP/CALM2/PPP3R1/EP300/MAPK1	1.90892592980914
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	24/1451	110/9376	1.40983647641125	INHBA/TGFBR1/HAMP/FBN1/SMAD7/EMP3/CDKN2B/SKIL/BMPR2/SMAD4/SMURF2/SKP1/NOG/TNF/ID3/TGFB1/NCOR1/TGIF1/CREBBP/SMAD6/SP1/SMAD2/EP300/MAPK1	1.85003741930016
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	19/1451	83/9376	1.47919590145558	LCOR/FBRS/SCML1/PHF1/BMI1/SKP1/MBD6/PHC2/UBE2D3/EZH1/UBE2D4/CBX7/KDM2A/L3MBTL3/CREBBP/RYBP/TEX10/EP300/E2F6	1.87626372207258
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	6/1451	18/9376	2.15391683896164	OLAH/ACSL4/ACSL3/ACSL1/MECR/ACSL5	2.09671282713059
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	26/1451	122/9376	1.37709437245088	PTPRC/CD4/LCP2/NFKBIA/PTPN6/PAK2/IL10/SOS2/VAV1/IKBKB/RELA/NFKBIE/MAP2K7/TNF/GSK3B/PIK3R1/MAPK8/NFKB1/PDPK1/SOS1/LAT/PIK3CA/PPP3R1/MAPK1/NFKBIB/PPP2R2D	1.79384505609212
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	18/1451	79/9376	1.47229758612567	CLTB/VAMP2/ATP6V0E1/AP2A2/STX3/ATP6V1B2/ATP6V1C1/SLC1A3/ATP6V1G1/SLC6A2/SYT1/ATP6V0D1/AP2M1/TCIRG1/ATP6V0B/ATP6V1F/CLTC/SLC6A4	1.80375507107547
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	32/1451	157/9376	1.3170446913396	IRS2/COX4I1/PRKAG2/IL1B/IL6R/BID/NR1H3/SREBF1/DDIT3/ATF4/PRKAB2/CASP7/BCL2L11/RXRA/MT-CYB/IKBKB/RELA/MLXIP/ADIPOR1/TNF/NDUFA13/GSK3B/PIK3R1/MAPK8/IL1A/NFKB1/TGFB1/MAP3K5/NDUFB10/PIK3CA/CASP8/MAP3K11	1.71414719896682
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	10/1451	38/9376	1.70046066233813	HEXB/HK3/RENBP/GALT/AMDHD2/HEXA/GNPDA1/UAP1/GALE/PGM2	1.85126385972498
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	10/1451	38/9376	1.70046066233813	NT5E/NAMPT/NADK/NMRK1/NT5C2/NMNAT2/NADK2/BST1/CD38/SIRT2	1.85126385972498
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	14/1451	59/9376	1.53329673282015	IRS2/MGLL/ADCY7/FABP4/PNPLA2/PTGS2/PTGS1/PIK3R1/PRKG1/PRKACA/ADRB1/PRKACB/GNAI2/PIK3CA	1.75823366025577
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	34/1451	170/9376	1.29235010337698	AMOTL2/SYNPO/PRKAG2/TUBA4A/WAS/SYMPK/AMOT/MYL12B/AMOTL1/RAPGEF2/CLDN9/TJP2/MSN/PRKAB2/MYL12A/TUBA1A/NEDD4/YBX3/CLDN23/MAP2K7/RAP1A/MAPK8/HCLS1/PRKACA/PRKACB/RUNX1/EZR/SCRIB/MAP3K5/NEDD4L/ACTR3C/ARHGAP17/MICALL2/PPP2R2D	1.64593217931157
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	15/1451	65/9376	1.49117319620421	HSD3B1/ADCY7/NCEH1/ORAI1/SCARB1/CREB5/ATF4/GNAQ/PLCB2/PRKACA/PRKACB/ATF6B/CREB3/SP1/GNA11	1.70025038900422
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	5/1451	15/9376	2.15391683896164	HEXB/B3GALT4/HEXA/ST3GAL5/ST3GAL1	1.91372145962062
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	42/1451	217/9376	1.25066139036482	STAT5B/KLF4/PAQR7/ARRB2/STAT5A/ADCY7/EGFR/GSTT1/NOTCH2/KPNA3/GSTA3/CREB5/JAK2/AHR/BCL6/STAT3/SOS2/ATF4/BAD/ARRB1/PRKCB/RXRA/RELA/MIR29A/RPS6KA3/VDR/PIK3R1/KPNA6/KPNA1/PRKACA/RXRB/NFKB1/ADRB1/PRKACB/ATF6B/CREB3/SOS1/GNAI2/PIK3CA/GSTM3/IKBKE/MAPK1	1.59850128845735
NA	NA	hsa04518	Integrin signaling	31/1451	154/9376	1.30074198716514	SPP1/FN1/ITGB2/FBN1/FERMT3/ITGAX/ICAM1/PARVG/EGFR/ITGAM/PDGFB/ITGAL/RAC2/LAMB3/VEGFB/LAMB2/FLT1/PARVB/ITGAV/GSK3B/PIK3R1/TGFB1/ITGB6/ITGA3/THBS3/ARHGEF6/ITGB3/PIK3CA/ITGA2/ICAM2/ITGA4	1.61013234903518
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	14/1451	60/9376	1.50774178727315	HSPB1/MAPKAPK3/PTGS2/RAC2/BAD/PRKCB/PIK3R1/PLA2G4C/MAPKAPK2/PLCG2/PIK3CA/PPP3R1/MAPK1/SPHK1	1.68819846733877
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	6/1451	20/9376	1.93852515506547	CYB5R1/NPL/UAP1/NANP/CYB5R3/CYB5R4	1.79777574859869
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	19/1451	88/9376	1.39515067978197	CD59/ITGB2/C1QB/C1QA/SERPINE1/SERPINA1/C5AR1/C1QC/SERPINE2/C3AR1/PLAUR/A2M/ITGAX/PLAU/CFB/ITGAM/VSIG4/C2/CLU	1.59353892034994
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	28/1451	139/9376	1.30164758613509	CTSD/MMP9/ADCY7/EGFR/HBEGF/CREB5/KRT18/SOS2/ATF4/HSPA6/GNAQ/PLCB2/HSPA1A/KRT27/PIK3R1/PRKACA/EBAG9/PRKACB/ATF6B/CREB3/NCOA3/SOS1/GNAI2/HSPA1B/CALM2/SP1/PIK3CA/MAPK1	1.53306825763385
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	12/1451	51/9376	1.52041188632586	PLA2G7/PLD3/PAFAH1B2/CEPT1/PAFAH2/PLA2G2F/LPCAT2/PLA2G4C/TMEM86A/PLD1/GDPD3/PLA2G12A	1.59451123691378
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	19/1451	89/9376	1.37947482944734	GLUL/GABARAPL2/GABARAPL1/SLC38A1/GABARAP/GNGT1/GNG11/ADCY7/SLC38A2/PRKCB/GNGT2/GNG12/PRKACA/PRKACB/GNB4/GNAI2/ABAT/TRAK2/GNG5	1.53907563862526
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	31/1451	157/9376	1.27588704473524	ITGB2/SERPINE1/TGFBR1/SMAD7/STK3/BBC3/BIRC3/SAV1/AMOT/YWHAG/BMPR2/SMAD4/DVL1/LIMD1/GSK3B/YWHAH/DVL3/WNT7A/TGFB1/APC/FZD1/YWHAZ/LATS2/FZD7/SCRIB/AREG/FBXW11/SMAD2/DLG5/LATS1/PPP2R2D	1.49162253108849
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	10/1451	41/9376	1.57603671143534	CDKN1A/DAPK1/MMP9/EGFR/HBEGF/CDKN2A/RPS6KA5/TYMP/ARAF/MAPK1	1.58162906974648
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	21/1451	101/9376	1.34353228568894	ADCY7/MITF/PRKCB/GNAQ/PLCB2/CAMK2D/CAMK2G/DVL1/GSK3B/DVL3/WNT7A/PRKACA/PRKACB/FZD1/CREB3/CREBBP/FZD7/GNAI2/CALM2/EP300/MAPK1	1.48522070750815
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	13/1451	57/9376	1.47373257402638	PPT1/ACAA2/ACADVL/ACSL4/ACSL3/ACSL1/TECR/CPT1A/ACOX1/MECR/ACSL5/CPT2/ACADS	1.53499063062524
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	6/1451	21/9376	1.84621443339569	DSE/CSGALNACT1/CSGALNACT2/CHST11/B3GAT3/CHPF2	1.66106982532752
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	40/1451	212/9376	1.219198210733	ITGB2/ANGPT2/MRAS/RRAS/PFN2/LCP2/CSF1R/ADCY7/EGFR/ITGAM/DOCK4/RALGDS/RASGRP3/PDGFB/SIPA1/ITGAL/FPR1/RAPGEF2/RAC2/APBB1IP/MAP2K3/BCAR1/PRKCB/VAV1/VEGFB/GNAQ/PLCB2/FLT1/RAP1A/PIK3R1/RASSF5/KRIT1/GNAI2/SIPA1L1/LAT/CALM2/ITGB3/CSF1/PIK3CA/MAPK1	1.38128120983177
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	30/1451	154/9376	1.25878256822433	CDKN1A/RGS2/ADCY7/PRKAG2/EGFR/KCNJ2/ELK1/PTGS2/PIK3R5/PPP1R12B/CAMK1/PRKCB/PRKAB2/GNAQ/PLCB2/CAMK2D/CAMK2G/RCAN1/CAMK1D/MEF2C/PLA2G4C/PRKACA/PPP1R12C/PRKACB/MYLK/GNAI2/CALM2/CD38/PPP3R1/MAPK1	1.38548723572674
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	20/1451	97/9376	1.33231969420307	GNGT1/GNG11/ADCY7/PER2/PRKCB/GNAQ/PLCB2/CAMK2D/CAMK2G/GNGT2/RPS6KA5/GNG12/PRKG1/PRKACA/PRKACB/GNB4/GNAI2/CALM2/MAPK1/GNG5	1.40770310421992
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	9/1451	37/9376	1.57177715275579	APOL1/IL18/ICAM1/IL1B/IL10/PRKCB/GNAQ/PLCB2/TNF	1.49106707694027
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	12/1451	53/9376	1.4630378528796	CLTB/AP2A2/SLC8A1/PRKCB/GNAQ/PLCB2/ATP1B1/AP2M1/VDR/PRKACA/PRKACB/CLTC	1.44642625804273
NA	NA	hsa03272	Virion - Hepatitis viruses	11/1451	48/9376	1.48081782678612	LAMP2/EGFR/IST1/CD9/SCARB1/CLDN9/PDCD6IP/TGOLN2/CD63/CLDN23/VPS4B	1.42898154543219
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	69/1451	388/9376	1.14912573625015	APOE/MT-ND2/MT-ND4L/LPL/MT-ND3/SLC39A8/MT-ND5/MT-ND1/MT-ATP6/CYBB/MT-ND4/IRS2/SLC11A2/COX4I1/TUBA4A/IL1B/BID/SLC39A13/PTGS2/ADAM10/DDIT3/ATF4/BAD/RTN3/TUBA1A/MT-ATP8/CASP7/ULK1/GNAQ/PLCB2/MT-CYB/IKBKB/RELA/SLC39A6/SLC39A11/DVL1/MAP2K7/FRAT1/TNF/NDUFA13/SLC39A9/GSK3B/PIK3R1/FADD/ARAF/DVL3/MAPK8/WNT7A/IL1A/NFKB1/APC/PSEN1/PSMD9/FZD1/SLC39A1/FZD7/FRAT2/MAP3K5/APH1B/BECN1/CALM2/NDUFB10/CSF1/PIK3CA/CASP8/PPP3R1/MAPK1/CDK5/NCSTN	1.28367960357724
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	26/1451	133/9376	1.26319934916547	GNGT1/GNG11/ARRB2/CREB5/ATF4/ARRB1/PRKCB/GNAQ/PLCB2/CAMK2D/CAMK2G/GNGT2/GSK3B/GNG12/MAPK8/PRKACA/PRKACB/ATF6B/CREB3/GNB4/MAOA/GNAI2/CALM2/CLOCK/PPP2R2D/GNG5	1.30804855075132
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	12/1451	54/9376	1.43594455930776	CDO1/SDS/IL4I1/SDSL/AMD1/DNMT3A/LACC1/BCAT2/SMS/APIP/BCAT1/GCLC	1.37465368787931
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	19/1451	93/9376	1.32014257871842	TGFBR1/SORBS1/PTPN6/WAS/EGFR/MYL12B/SMAD4/PTPRJ/RAC2/SMURF2/MYL12A/LMO7/RAP1A/BAIAP2/KRIT1/CREBBP/EP300/PTPN1/MAPK1	1.32757922266052
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	20/1451	99/9376	1.30540414482523	CDKN1A/MMP9/ADCY7/EGFR/HBEGF/NOTCH2/CDKN2A/SOS2/BAD/PIK3R1/ARAF/MAPK8/PRKACA/PRKACB/NCOR1/NCOA3/SOS1/SP1/PIK3CA/MAPK1	1.30709891696628
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	20/1451	99/9376	1.30540414482523	ADCY7/PTGER4/IL1B/IL1RAP/MAP2K3/PRKCB/GNAQ/PLCB2/CAMK2D/CAMK2G/HRH1/PIK3R1/PLA2G4C/MAPK8/PRKACA/PRKACB/P2RY2/CALM2/PLCG2/PIK3CA	1.30709891696628
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	11/1451	49/9376	1.4505970548109	CREB5/ATF4/RELA/PRKACA/NFKB1/PRKACB/ATF6B/CREB3/MAOA/GNAI2/CDK5	1.35311624912084
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	7/1451	28/9376	1.61543762922123	ATP6V0E1/ATP6V1B2/ATP6V1C1/ATP6V1G1/ATP6V0D1/TCIRG1/ATP6V1F	1.39547936593364
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	5/1451	18/9376	1.7949306991347	TCN2/LMBRD1/CD320/PRDX1/ZNF76	1.44442072190873
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	17/1451	83/9376	1.32349106972341	SOD1/ACSL4/ACSL3/SOD2/ACSL1/ABCD1/HMGCL/ECH1/CROT/ACOX1/CAT/PEX11B/ACSL5/PRDX1/GSTK1/PRDX5/NUDT19	1.26661049623513
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	18/1451	89/9376	1.30687089105537	MAP3K2/ADCY7/TUBA4A/EGFR/PDGFB/SOS2/PRKCB/TUBA1A/GNAQ/PLCB2/PRKG1/PRKACA/ADRB1/PRKACB/SOS1/GNAI2/GNA11/MAPK1	1.24460827432059
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	36/1451	195/9376	1.19293855696337	ITGB2/FCGR3A/NCF2/C5AR1/FPR3/CYBB/AQP9/FCGR1A/NCF4/CASP1/FCGR2A/SYK/ITGAM/ITGAL/FPR1/RAC2/TLR4/PRKCB/SIGLEC9/CASP4/PLCB2/TLR2/SELPLG/RELA/TLR7/ATG7/PIK3R1/FCGR3B/NFKB1/GSDMD/NCF1/CLEC7A/ITGB3/PLCG2/PIK3CA/MAPK1	1.16496008919847
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	7/1451	29/9376	1.55973288338601	STK3/RASSF4/SAV1/RASSF2/LIMD1/LATS2/LATS1	1.29170520120906
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	17/1451	85/9376	1.29235010337698	UCK2/UPP1/NT5E/CDA/NME3/GDA/LACC1/ENTPD4/AMPD3/ENTPD1/TK2/RRM2B/TYMP/NT5C2/CMPK2/AK9/UCKL1	1.15851375236781
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	17/1451	86/9376	1.27732277659353	CCK/VAMP2/ADCY7/CREB5/ATF4/PRKCB/GNAQ/PLCB2/CAMK2D/CAMK2G/ATP1B1/KCNMA1/PRKACA/PRKACB/ATF6B/CREB3/GNA11	1.10546912456239
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	11/1451	52/9376	1.36690876318719	HSD17B1/HSD3B1/ALOX5/ADCY7/SCARB1/PTGS2/CYP19A1/PLA2G4C/PRKACA/PRKACB/ACOT2	1.1352155538609
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	42/1451	235/9376	1.15486604982624	MT-ND2/MT-ND4L/MT-ND3/MT-ND5/MT-ND1/MT-ATP6/MT-ND4/MGLL/COX4I1/ADCY7/PRKAG2/ACSL4/PNPLA2/ACSL3/ACSL1/COX17/CREB5/MAP2K3/SOS2/PRKAB2/MT-ATP8/MT-CYB/COX14/RHEB/NDUFA13/RPS6KA3/CPT1A/SMARCC2/SLC25A20/PRKG1/PRKACA/PRKACB/ACSL5/CREB3/FRS2/SOS1/COA5/MAP3K5/NDUFAF3/CPT2/NDUFB10/ARID1B	1.02875748146846
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	82/1451	480/9376	1.10388237996784	MT-ND2/MT-ND4L/MAP1LC3B/SQSTM1/PINK1/MT-ND3/MT-ND5/MT-ND1/MT-ATP6/CYBB/MT-ND4/SOD1/COX4I1/TUBA4A/PRNP/IL1B/BID/OPTN/BCL2L1/PTGS2/MAP2K3/DDIT3/GPX1/ATF4/BAD/PRKCB/TUBA1A/UBE2J1/MT-ATP8/ATXN1/CASP7/ULK1/MFN2/UBE2L6/GNAQ/PLCB2/MT-CYB/RELA/CAMK2D/CAMK2G/UBC/C9orf72/DVL1/ATXN2/MAP1LC3B2/MAP2K7/FRAT1/TNF/NDUFA13/DAXX/GSK3B/FADD/ARAF/LRRK2/DVL3/MAPK8/WNT7A/IL1A/NFKB1/CAT/APC/UBA7/PSEN1/PSMD9/FZD1/ATXN1L/FIG4/ACTR1A/FZD7/FRAT2/MAP3K5/BECN1/CALM2/NDUFB10/CSF1/CASP8/PPP3R1/GPR37/MAPK1/CDK5/DCTN1/DNAH11	0.999734849644588
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	37/1451	205/9376	1.16626716646215	MT-ND2/CTSD/MT-ND4L/NCF2/TGFBR1/CD36/MT-ND3/MMP9/MT-ND5/MT-ND1/PDK4/MT-ATP6/CYBB/MT-ND4/COX4I1/NCF4/RAC2/PRKCB/MT-ATP8/PLCB2/MT-CYB/RELA/CAMK2D/CAMK2G/MPC1/NDUFA13/GSK3B/PIK3R1/MAPK8/NFKB1/TGFB1/NCF1/CPT2/SP1/SMAD2/NDUFB10/PIK3CA	1.02989936019252
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	22/1451	116/9376	1.22550440837472	GLUL/HOMER3/SLC38A1/GNGT1/GNG11/ADCY7/SLC38A2/SLC1A3/PRKCB/GNAQ/PLCB2/GNGT2/GNG12/PLA2G4C/PRKACA/PRKACB/PLD1/GNB4/GNAI2/PPP3R1/MAPK1/GNG5	1.0456786634437
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	10/1451	47/9376	1.37484053550743	SOCS2/IRS2/HK3/IKBKB/TNF/PIK3R1/MAPK8/PIK3CA/MAPK1/SOCS1	1.10229450149649
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	15/1451	76/9376	1.2753454967536	ADCY7/KCNJ2/SLC4A2/PRKCB/GNAQ/PLCB2/CAMK2D/CAMK2G/ATP1B1/PRKACA/PRKACB/EZR/MYLK/GNAI2/CALM2	1.03124773781179
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	47/1451	268/9376	1.13321744139399	MT-ND2/MT-ND4L/PINK1/MT-ND3/SLC39A8/MT-ND5/MT-ND1/DUSP1/MT-ATP6/MT-ND4/SOD1/SLC11A2/COX4I1/TUBA4A/TXN/SLC39A13/BCL2L1/NFE2L2/DDIT3/ATF4/TUBA1A/UBE2J1/MT-ATP8/MFN2/UBE2L6/MT-CYB/CAMK2D/SLC39A6/CAMK2G/UBC/SLC39A11/NDUFA13/DAXX/SLC39A9/LRRK2/MAPK8/PRKACA/PRKACB/UBA7/PSMD9/SLC39A1/MAOA/MAP3K5/GNAI2/CALM2/NDUFB10/GPR37	0.94675298539237
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	7/1451	31/9376	1.45910495542562	DPYD/ALDH3B1/ACOX1/ALDH3A2/ABAT/CNDP2/ACADS	1.09552649031051
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	33/1451	184/9376	1.15890090791958	RHOD/CXCR4/RASA1/RRAS/PLXNC1/MYL12B/BMPR2/PAK2/ARHGEF12/RAC2/SEMA3C/MYL12A/SEMA4A/EPHB2/CAMK2D/CAMK2G/EPHB6/DPYSL2/NRP1/GSK3B/PIK3R1/SSH3/PLXNA2/PDPK1/SEMA7A/GNAI2/EPHA1/LIMK2/PLCG2/PIK3CA/PPP3R1/MAPK1/CDK5	0.931429505623396
Organismal Systems	Nervous system	hsa04730	Long-term depression	12/1451	60/9376	1.29235010337698	CRH/PRKCB/GNAQ/PLCB2/PLA2G4C/ARAF/PRKG1/GNA13/GNAI2/GNA11/LYN/MAPK1	0.972039349169905
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	5/1451	21/9376	1.53851202782974	DPYD/PPCS/BCAT2/BCAT1/ALDH3A2	1.05706785975565
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	27/1451	150/9376	1.16311509303928	CDKN1A/TGFBR1/EGFR/GADD45B/CDKN2B/SMAD4/GAB1/SOS2/RXRA/DVL1/DDB2/FRAT1/GSK3B/PIK3R1/ARAF/DVL3/WNT7A/RXRB/TGFB1/APC/FZD1/SOS1/FZD7/FRAT2/SMAD2/PIK3CA/MAPK1	0.861693390044105
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	8/1451	38/9376	1.36036852987051	SCNN1B/PRKCB/ATP1B1/PIK3R1/PDPK1/NEDD4L/PIK3CA/MAPK1	0.95242641221934
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	8/1451	38/9376	1.36036852987051	PTPRC/CD4/CD40/IL2RG/BTK/ORAI1/IL7R/CIITA	0.95242641221934
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	4/1451	16/9376	1.61543762922123	HEXB/GBGT1/HEXA/ST3GAL1	1.05420682219944
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	9/1451	44/9376	1.32172169663555	HEXB/MAN1C1/FUT8/MAN1A1/HEXA/ALG3/MGAT4A/B4GALT3/MAN2A2	0.915248514128545
Human Diseases	Substance dependence	hsa05032	Morphine addiction	17/1451	91/9376	1.20714020645103	GNGT1/GNG11/ARRB2/ADCY7/PDE7A/ARRB1/PRKCB/PDE4B/GRK4/GNGT2/GNG12/PRKACA/PRKACB/GNB4/GNAI2/PDE10A/GNG5	0.849598732567766
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	21/1451	115/9376	1.17997183351811	ALOX5/DUSP1/GNGT1/GNG11/PTGS2/PTGS1/PRKCB/GNAQ/PLCB2/GNGT2/GNG12/PLA2G4C/ARAF/PRKACA/PRKACB/GNB4/MAOA/GNAI2/MAPK1/SLC6A4/GNG5	0.830891331768339
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	11/1451	56/9376	1.26927242295954	ARRB2/KIF3A/SMURF2/ARRB1/SPOPL/SPOP/GSK3B/PRKACA/PRKACB/FBXW11/GLI3	0.864764085247331
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	5/1451	22/9376	1.46857966292839	AOC1/ALDH3B1/ALDH3A2/MAOA/CNDP2	0.941490196605972
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	12/1451	63/9376	1.23080962226379	GPX4/HPGD/ALOX5/TBXAS1/CBR1/PTGS2/PTGS1/LTA4H/PLA2G2F/LTC4S/PLA2G4C/PLA2G12A	0.78650066192482
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	4/1451	17/9376	1.52041188632586	SEPHS2/TXNRD1/PAPSS2/TXNRD2	0.918917777264618
Organismal Systems	Endocrine system	hsa04924	Renin secretion	13/1451	69/9376	1.2174312568044	CTSB/PTGER4/KCNJ2/ORAI1/GNAQ/PLCB2/KCNMA1/PRKACA/ADRB1/PRKACB/GNAI2/CALM2/PPP3R1	0.775642100111468
Organismal Systems	Digestive system	hsa04970	Salivary secretion	17/1451	93/9376	1.18118020201122	LYZ/TRPV6/VAMP2/ADCY7/SLC4A2/PRKCB/GNAQ/PLCB2/ATP1B1/KCNMA1/PRKG1/PRKACA/ADRB1/PRKACB/BST1/CALM2/CD38	0.751324840045996
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	29/1451	166/9376	1.12886003005821	RGS2/IRS2/ADCY7/GTF2I/SLC8A1/CREB5/PIK3R5/ATF4/BAD/CNGA1/GNAQ/PLCB2/MEF2A/ATP1B1/KCNMA1/MEF2C/MEF2D/PRKG1/ADRB1/GNA13/ATF6B/CREB3/MYLK/GNAI2/CALM2/GNA11/PPP3R1/MAPK1/ADORA3	0.716740864543162
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	26/1451	149/9376	1.12755378146985	MT-ND2/MT-ND4L/MT-ND3/MT-ND5/MT-ND1/MT-ND4/GNGT1/GNG11/MGLL/ADCY7/DAGLB/PTGS2/PRKCB/GNAQ/PLCB2/GNGT2/NDUFA13/GNG12/MAPK8/PRKACA/PRKACB/GNB4/GNAI2/NDUFB10/MAPK1/GNG5	0.671546238945183
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	19/1451	107/9376	1.14741364318517	FBP1/PRKAG2/CREB5/ATF4/PRKAB2/GNAQ/PLCB2/CAMK2D/CAMK2G/CRTC2/CPT1A/PRKACA/PRKACB/CREB3/CREBBP/CALM2/PYGB/PPP3R1/EP300	0.656194878148713
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	25/1451	144/9376	1.12183168695919	INHBA/KLF4/SKIL/BMPR2/SMAD4/JAK2/KAT6A/BMI1/STAT3/LIFR/DVL1/ID3/GSK3B/PIK3R1/DVL3/DUSP9/WNT7A/APC/FZD1/FZD7/IL6ST/SMAD2/ISL1/PIK3CA/MAPK1	0.630395805621434
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	12/1451	65/9376	1.19293855696337	LPL/MGLL/LPIN2/GK/PNPLA2/DGKZ/LPIN1/ALDH3A2/DGKA/AGPAT2/AGPAT3/DGKH	0.667878172233345
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	4/1451	18/9376	1.43594455930776	HEXB/HEXA/MANBA/FUCA2	0.792128616686871
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	46/1451	275/9376	1.08087463191529	MT-ND2/MT-ND4L/C1QB/CCL5/C1QA/NCF2/MT-ND3/MT-ND5/MT-ND1/MT-ATP6/CYBB/C1QC/MT-ND4/SOD1/COX4I1/NCF4/TUBA4A/PRNP/IL1B/CREB5/RAC2/DDIT3/ATF4/BAD/HSPA6/TUBA1A/MT-ATP8/MT-CYB/HSPA1A/TNF/NDUFA13/GSK3B/PIK3R1/MAPK8/IL1A/PRKACA/PRKACB/ATF6B/PSMD9/CREB3/NCF1/HSPA1B/NDUFB10/PIK3CA/PPP3R1/MAPK1	0.582443517203895
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	6/1451	30/9376	1.29235010337698	B3GALT4/PGAP3/GPAA1/DPM2/PIGC/PIGQ	0.686231579303226
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	9/1451	48/9376	1.21157822191592	IL4I1/ACAA2/BCAT2/HMGCL/AUH/BCAT1/ALDH3A2/ABAT/ACADS	0.628806499447228
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	21/1451	122/9376	1.11226853159494	FBP1/CD36/IRS2/TBC1D1/PRKAG2/FOXO3/CREB5/CAB39/SREBF1/PRKAB2/ULK1/PFKFB3/ADIPOR1/CRTC2/RHEB/CPT1A/PIK3R1/CREB3/PDPK1/PIK3CA/PPP2R2D	0.534063526451971
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	30/1451	178/9376	1.08905907587948	MMP7/SMAD4/RAC2/TBL1XR1/TLE2/PRKCB/SKP1/PLCB2/PORCN/CAMK2D/CAMK2G/DVL1/FRAT1/GSK3B/DVL3/MAPK8/WNT7A/PRKACA/TLE6/PRKACB/APC/PSEN1/FZD1/ANKRD6/CREBBP/FZD7/FRAT2/FBXW11/PPP3R1/EP300	0.513288095415942
Human Diseases	Cancer: specific types	hsa05218	Melanoma	13/1451	73/9376	1.15072269478772	CDKN1A/EGFR/GADD45B/PDGFB/CDKN2A/MITF/BAD/CDK6/DDB2/PIK3R1/ARAF/PIK3CA/MAPK1	0.553156829672423
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	8/1451	43/9376	1.20218614267626	CD36/ABCA1/SCARB1/PLA2G2F/AGPAT2/SLC27A1/PLA2G12A/SLC27A4	0.568584073631981
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	25/1451	148/9376	1.09151191163596	CDKN1A/EGFR/GADD45B/NOTCH2/SOS2/NFKB2/CDK6/DVL1/DDB2/FRAT1/GSK3B/PIK3R1/ARAF/DVL3/WNT7A/APC/HES1/FZD1/NCOA3/SOS1/FZD7/FRAT2/SP1/PIK3CA/MAPK1	0.480147200859595
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	3/1451	14/9376	1.38466082504677	FUT8/ST3GAL1/B4GALT3	0.61627899715944
NA	NA	hsa04081	Hormone signaling	36/1451	219/9376	1.06220556441944	CSH1/CSH2/CSHL1/CCK/GH2/CRH/STAT5B/HAMP/GNGT1/GNG11/IRS2/STAT5A/ADCY7/GNA15/SMAD4/JAK2/SLC16A10/STAT3/GNAQ/PLCB2/GNGT2/ADIPOR1/ITGAV/PIK3R1/GNG12/PRKG1/PRKACA/ADRB1/GNA13/PRKACB/GNB4/GNAI2/GNA11/ITGB3/PIK3CA/GNG5	0.398560627809237
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	6/1451	32/9376	1.21157822191592	GABARAPL2/GABARAPL1/GABARAP/ATG3/ATG7/BECN1	0.512978598019193
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	5/1451	26/9376	1.24264433017017	TCN2/SCARB1/LMBRD1/BTD/SLC46A1	0.530115771586573
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	12/1451	69/9376	1.12378269858868	CREB5/ATF4/PRKCB/CAMK2D/CAMK2G/PRKACA/PRKACB/ATF6B/CREB3/MAOA/CALM2/PPP3R1	0.441569780269256
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	11/1451	63/9376	1.12824215374181	CDKN1A/GADD45B/DVL1/DDB2/GSK3B/DVL3/WNT7A/APC/FZD1/FZD7/GLI3	0.436994514419862
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	14/1451	82/9376	1.10322569800474	UCK2/UPP1/CDA/NME3/DPYD/GSTT1/GSTA3/CES2/TK2/RRM2B/TYMP/GSTM3/GUSB/UCKL1	0.401710449821585
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	22/1451	134/9376	1.06088441321991	ADCY7/ARHGEF12/PPP1R12B/PRKCB/GNAQ/PLCB2/PLA2G2F/KCNMA1/PLA2G4C/ARAF/ADM/PRKG1/PRKACA/PPP1R12C/ARHGEF11/GNA13/PRKACB/MYLK/CALM2/GNA11/PLA2G12A/MAPK1	0.30373528776699
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	11/1451	65/9376	1.09352701054975	SPP1/KISS1/ARRB2/ARRB1/PRKCB/GNAQ/PLCB2/PIK3R1/GNA11/PIK3CA/MAPK1	0.323754099976389
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	10/1451	59/9376	1.09521195201439	GPX4/GSTT1/GSTA3/GPX1/SMS/ANPEP/RRM2B/GSTK1/GCLC/GSTM3	0.313905652496874
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	5/1451	28/9376	1.1538840208723	PPT1/ACAA2/TECR/MECR/ACOT2	0.348925651728408
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	36/1451	226/9376	1.02930539207016	CRH/RRAS/ADCY7/NFKBIA/ORAI1/CREB5/RAC2/BAD/VAV1/SUCNR1/CNGA1/RELA/PDE4B/CAMK2D/CAMK2G/ATP1B1/RAP1A/PIK3R1/RRAS2/MAPK8/ACOX1/PRKACA/NFKB1/ADRB1/PRKACB/CREB3/PLD1/CREBBP/GNAI2/HCAR2/CALM2/GLI3/PIK3CA/PDE10A/EP300/MAPK1	0.190814299615541
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	23/1451	143/9376	1.03930253068778	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DQB1/HLA-DQA1/HLA-DMA/FCGR3A/C1QB/HLA-DMB/C1QA/HLA-DQA2/CD86/C1QC/FCGR1A/FCGR2A/HLA-DRB5/CD40/C2/HLA-DOA/IL10/TNF/FCGR3B	0.2026454352692
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	37/1451	233/9376	1.02611488894739	FN1/FBLN1/FBN1/VIM/FMNL2/FMNL1/PDLIM4/CSRP1/ANK3/PDLIM5/BGN/TMEM43/ZYX/FBN2/SDC2/AMPD3/TRIM55/FHL1/DIAPH2/ATP1B1/SUN2/PLEC/FMNL3/ITGAV/SYNE1/SGCE/LMNA/CAPZA2/SUN1/SNTB1/ITGB6/ITGA3/PDLIM7/THBS3/ITGB3/ITGA2/ITGA4	0.172719548064302
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	3/1451	16/9376	1.21157822191592	IL4I1/ALDH3B1/MAOA	0.362420486467221
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	22/1451	138/9376	1.03013414037296	MT-ND2/MT-ND4L/MT-ND3/MT-ND5/MT-ND1/MT-ATP6/MT-ND4/COX4I1/ATP6V0E1/ATP6AP1/ATP6V1B2/ATP6V1C1/ATP6V1G1/COX17/MT-ATP8/MT-CYB/ATP6V0D1/TCIRG1/NDUFA13/ATP6V0B/ATP6V1F/NDUFB10	0.152591056586882
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	4/1451	23/9376	1.12378269858868	CTSA/LNPEP/ATP6AP2/ANPEP	0.254312733723369
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	6/1451	36/9376	1.07695841948082	GALNT7/B4GALT5/ST3GAL1/B3GNT3/GALNT18/ST6GALNAC2	0.197949159072187
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	12/1451	75/9376	1.03388008270159	ADCY7/CREB5/GPX1/ATF4/PRKCB/GNAQ/PLCB2/ATP1B1/PRKACA/PRKACB/ATF6B/CREB3	0.126046264727137
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	3/1451	17/9376	1.1403089147444	LAMP2/PCDH1/NRP2	0.247750598045715
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	14/1451	89/9376	1.01645513748751	SPP1/FN1/CD44/CD36/LAMB3/LAMB2/CD47/ITGAV/ITGB6/ITGA3/THBS3/ITGB3/ITGA2/ITGA4	0.0667388171019012
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	6/1451	37/9376	1.04785143517053	HK3/GALT/UAP1/NANP/GALE/PGM2	0.124785852710674
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	6/1451	37/9376	1.04785143517053	CDKN1A/GADD45B/RXRA/DDB2/RXRB/MAPK1	0.124785852710674
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	4/1451	24/9376	1.07695841948082	HS3ST3B1/EXTL1/B3GAT3/GLCE	0.161521084018791
NA	NA	hsa04981	Folate transport and metabolism	5/1451	31/9376	1.04221782530402	SLCO2B1/ABCC3/MTHFR/FOLR2/SLC46A1	0.100741116899892
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	5/1451	32/9376	1.00964851826327	HK3/GALT/GALM/GALE/PGM2	0.0233931608217223
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	16/1451	105/9376	0.984647697811034	ADCY7/SLC8A1/TNF/ITGAV/SGCE/LMNA/PRKACA/SNTB1/ADRB1/TGFB1/PRKACB/ITGB6/ITGA3/ITGB3/ITGA2/ITGA4	-0.0676900100024181
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	2/1451	12/9376	1.07695841948082	COQ6/NQO1	0.114139448388235
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/1451	12/9376	1.07695841948082	FCGR2B/NPC1	0.114139448388235
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	7/1451	46/9376	0.983309861265095	FTL/HMOX1/BLVRA/HMOX2/EARS2/GUSB/FXN	-0.0485531878574197
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	4/1451	26/9376	0.99411546413614	PLA2G2F/PLA2G4C/ACOX1/PLA2G12A	-0.0128562050788967
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	7/1451	48/9376	0.942338617045716	HK3/PRKCB/PLCB2/ATP1B1/PIK3R1/SLC2A5/PIK3CA	-0.171368546537735
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	5/1451	35/9376	0.923107216697844	FBP1/HSD17B14/HK3/PFKFB3/ENOSF1	-0.195003598878235
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	4/1451	28/9376	0.923107216697844	ALPP/CBR1/PCBD1/MOCOS	-0.174351205374208
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	17/1451	117/9376	0.938886827239687	BAZ2B/SRCAP/SMARCA1/MBD2/MEAF6/BCL7B/INO80C/BRD7/SMARCC2/BAZ1B/DPF2/GATAD2B/EPC2/BRD8/EPC1/KAT5/ARID1B	-0.284620009622175
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	8/1451	56/9376	0.923107216697844	MAN1C1/FUT8/MAN1A1/ALG3/MGAT4A/DPM2/B4GALT3/MAN2A2	-0.246939945366788
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	9/1451	63/9376	0.923107216697844	ASH1L/KMT2E/EZH1/SETDB2/KMT2B/ALDH3A2/KMT2C/EHMT2/DOT1L	-0.262017780590054
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	7/1451	50/9376	0.904645072363887	AOC1/SAT1/AMD1/SMS/ALDH3A2/MAOA/CNDP2	-0.289267835881823
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	37/1451	254/9376	0.941278618601345	CXCR4/ADCY7/EGFR/PTAFR/GNA15/PDGFB/MCOLN1/ORAI1/TPCN1/SLC8A1/CAMK1/PRKCB/VEGFB/P2RX7/GNAQ/PLCB2/CAMK2D/CAMK2G/FLT1/CAMK1D/ORAI3/HRH1/STIM2/ORAI2/P2RX4/PRKACA/ADRB1/ITPKC/PRKACB/PLCD3/MYLK/CALM2/CD38/GNA11/PLCG2/PPP3R1/SPHK1	-0.405964256103903
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	14/1451	99/9376	0.913782901377664	PRKAG2/SLC8A1/PRKAB2/TNF/ITGAV/SGCE/LMNA/SNTB1/TGFB1/ITGB6/ITGA3/ITGB3/ITGA2/ITGA4	-0.369000480650713
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	6/1451	44/9376	0.881147797757033	GTF2I/TBP/GTF2A1/TAF10/TAF6/TAF7	-0.338116150204839
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	18/1451	128/9376	0.90868366643694	NT5E/ADCY7/NME3/GDA/NUDT9/PDE7A/LACC1/ENTPD4/AMPD3/ENTPD1/PAPSS2/PDE4B/RRM2B/NT5C2/ADPRM/PGM2/PDE10A/AK9	-0.445091447260811
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	15/1451	110/9376	0.881147797757033	ADCY7/ANAPC13/CPEB4/CPEB2/CPEB3/ANAPC16/RPS6KA3/PIK3R1/ARAF/MAPK8/PRKACA/PRKACB/GNAI2/PIK3CA/MAPK1	-0.536509154678265
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	19/1451	138/9376	0.889661303049371	ADCY7/ANAPC13/YWHAG/CPEB4/SKP1/CPEB2/CAMK2D/CAMK2G/CPEB3/ANAPC16/RPS6KA3/YWHAH/PRKACA/PRKACB/YWHAZ/FBXW11/CALM2/PPP3R1/MAPK1	-0.558725025560253
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	2/1451	17/9376	0.76020594316293	CYP27A1/HSD3B7	-0.423416581173188
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	2/1451	17/9376	0.76020594316293	CDO1/ADO	-0.423416581173188
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/1451	17/9376	0.76020594316293	GLUL/CA12	-0.423416581173188
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	5/1451	41/9376	0.788018355717672	RAD50/POLD4/ATM/UIMC1/MUS81	-0.582039866893485
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	10/1451	78/9376	0.828429553446783	FN1/CLTB/GAB1/BCAR1/ELMO3/PIK3R1/HCLS1/CLTC/ACTR3C/PIK3CA	-0.651050566330347
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	6/1451	49/9376	0.79123475716958	GALNT7/LFNG/MFNG/GALNT18/B4GALT3/POGLUT1	-0.6269096508943
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	43/1451	308/9376	0.902127507227438	MT-ND2/CLTB/MT-ND4L/TGM2/MT-ND3/MT-ND5/MT-ND1/MT-ATP6/MT-ND4/SOD1/COX4I1/TUBA4A/BBC3/AP2A2/SLC1A3/SOD2/CREB5/GPX1/TUBA1A/MT-ATP8/ULK1/GNAQ/PLCB2/MT-CYB/AP2M1/MAP2K7/NDUFA13/MAPK8/POLR2C/PSMD9/CREB3/CLTC/TBP/ACTR1A/CREBBP/MAP3K5/BECN1/SP1/NDUFB10/CASP8/EP300/DCTN1/DNAH11	-0.747308567530213
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	5/1451	42/9376	0.76925601391487	AOC1/IL4I1/CAT/ALDH3A2/MAOA	-0.641269887051021
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	21/1451	158/9376	0.85884025857331	CDKN1A/ANAPC13/GADD45B/CDKN2B/YWHAG/SMAD4/CDKN2A/SKP1/ANAPC16/CDK6/TFDP2/ATM/GSK3B/YWHAH/RBL2/TGFB1/PDS5A/YWHAZ/CREBBP/SMAD2/EP300	-0.765668454784991
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	19/1451	144/9376	0.852592082088981	RBPJ/PRKCB/ATXN1/ULK1/GNAQ/PLCB2/ATXN2/PIK3R1/PUM2/MAPK8/PSMD9/ATXN1L/TBP/MAP3K5/BECN1/SP1/KAT5/PIK3CA/NFYA	-0.762735339925368
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	3/1451	27/9376	0.717972279653879	HMGCL/ABAT/ACADS	-0.627929386553252
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	3/1451	27/9376	0.717972279653879	TECR/ACOX1/ACOT2	-0.627929386553252
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/1451	10/9376	0.646175051688491	PAPSS2	-0.478995114817919
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	13/1451	102/9376	0.823556438426508	CCK/ADCY7/SLC4A2/PRKCB/GNAQ/PLCB2/ATP1B1/PLA2G2F/KCNMA1/RAP1A/BST1/CD38/PLA2G12A	-0.766641040638798
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	51/1451	368/9376	0.895514337937854	MT-ND2/MT-ND4L/MAP1LC3B/SQSTM1/PINK1/MT-ND3/MT-ND5/MT-ND1/MT-ATP6/MT-ND4/SOD1/ANXA11/COX4I1/PFN2/TUBA4A/CASP1/CHCHD10/BID/OPTN/NUP214/BCL2L1/MAP2K3/DDIT3/GPX1/ATF4/BAD/TUBA1A/MT-ATP8/ULK1/MT-CYB/ANXA7/UBQLN4/C9orf72/ATXN2/MAP1LC3B2/NXT1/TNF/NDUFA13/DAXX/CAT/PSMD9/SETX/FIG4/ACTR1A/MAP3K5/UBQLN2/BECN1/NDUFB10/PPP3R1/DCTN1/DNAH11	-0.874955828376417
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	3/1451	28/9376	0.692330412523383	ST3GAL6/B3GNT3/B4GALT3	-0.697628062476823
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	5/1451	44/9376	0.734289831464194	POLD4/POLB/PNKP/PARP4/XRCC1	-0.755904371649301
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	8/1451	67/9376	0.771552300523571	BPGM/FBP1/HK3/GALM/ALDH3B1/MINPP1/ALDH3A2/PGM2	-0.802957176748256
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	20/1451	154/9376	0.839188378816222	ADCY7/SLC8A1/CREB5/PIK3R5/ATF4/GNAQ/PLCB2/CAMK2D/CAMK2G/ATP1B1/RPS6KA5/PRKACA/ADRB1/PRKACB/ATF6B/CREB3/GNAI2/CALM2/MAPK1/PPP2R2D	-0.860963897357673
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/1451	20/9376	0.646175051688491	LIPA/SOAT1	-0.677763305427058
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	44/1451	323/9376	0.880238460504445	TIMP3/CDKN1A/MARCKS/CD44/VIM/MMP9/ZEB2/IRS2/HMOX1/PLAU/EGFR/DNMT3A/NOTCH2/PDGFB/BMPR2/PTGS2/DICER1/BMI1/CDKN2A/STAT3/SOS2/PRKCB/BCL2L11/ST14/IKBKB/PIM1/MIR29A/CDK6/RPS6KA5/ATM/PIK3R1/NFKB1/APC/EZR/FOXP1/SOS1/CREBBP/ITGB3/BMF/PLCG2/PIK3CA/EP300/MAPK1/SOCS1	-0.93722114871582
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	4/1451	37/9376	0.698567623447017	IL4I1/ALDH3B1/FAHD1/MAOA	-0.786068296775726
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	5/1451	45/9376	0.717972279653879	ABCA1/ABCA5/ABCC3/ABCD1/ABCA12	-0.81143487244234
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/1451	29/9376	0.668456950022577	GNGT1/CNGA1/CALM2	-0.765107598270604
NA	NA	hsa04082	Neuroactive ligand signaling	26/1451	199/9376	0.844248811251294	GNGT1/GNG11/ADCY7/SLC1A3/TAC3/P2RY11/PRKCB/SLC6A2/GNAQ/PLCB2/GNGT2/HRH1/GNG12/P2RX4/OGFR/PRKACA/ADRB1/PRKACB/P2RY2/GNB4/GNAI2/GNA11/OGFRL1/SLC6A4/GNG5/ADORA3	-0.950226748261761
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	5/1451	46/9376	0.702364186617925	PSMB9/PSMB10/PSMB8/PSMD9/PSME2	-0.865850655274236
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	6/1451	54/9376	0.717972279653879	POLI/WDR48/ERCC4/HES1/ERCC1/MUS81	-0.889311352970224
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	3/1451	30/9376	0.646175051688491	PLA2G2F/PLA2G4C/PLA2G12A	-0.830531100457982
Cellular Processes	Cell motility	hsa04814	Motor proteins	25/1451	194/9376	0.832699808876921	DYNLRB1/KIFC3/DYNLT1/TUBA4A/MYL12B/KIF3A/MYO5B/MYL12A/TUBA1A/DYNLT3/MYO1F/DYNC1LI2/MYO5A/MYO1G/KIF1B/CAPZA2/MYO1C/KIF2A/MYO9B/ACTR1A/KIF3B/DYNLRB2/DYNC1H1/DCTN1/DNAH11	-1.00750768341007
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	9/1451	78/9376	0.745586598102105	CNOT6L/LSM1/EXOSC4/BTG2/PATL1/EXOSC6/CNOT2/CNOT4/C1D	-0.965410959260274
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	5/1451	47/9376	0.687420267753714	HAGH/ME2/LDHD/ACYP2/ALDH3A2	-0.919204001423957
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	7/1451	63/9376	0.717972279653879	XPC/POLD4/DDB2/ERCC4/POLR2C/RAD23A/ERCC1	-0.961030075599971
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	10/1451	86/9376	0.751366339172664	SLC8A1/ITGAV/SGCE/LMNA/SNTB1/ITGB6/ITGA3/ITGB3/ITGA2/ITGA4	-0.991108046543159
NA	NA	hsa04382	Cornified envelope formation	28/1451	217/9376	0.833774260243214	S100A6/SPTLC3/S100A7/COL17A1/S100A11/KRT8/S100A9/TCHH/DST/S100A8/CLDN9/KRT18/KRT81/LAMB3/FURIN/ST14/UGCG/ABCA12/KRT27/TMEM79/CLDN23/PLEC/TCHHL1/SLC27A1/S100A4/SLC27A4/KRT7/PPP2R2D	-1.0600438256138
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	3/1451	31/9376	0.62533069518241	HSD17B14/ALDH3A2/GUSB	-0.894044256510727
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/1451	13/9376	0.49705773206807	RAD50	-0.776429466868068
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	2/1451	23/9376	0.56189134929434	GGPS1/PCYOX1	-0.900098397426623
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	2/1451	23/9376	0.56189134929434	POLD4/MLH3	-0.900098397426623
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	3/1451	32/9376	0.60578911095796	ACOX1/ABAT/ACADS	-0.955777713573219
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	4/1451	41/9376	0.630414684574137	BPGM/SDS/SDSL/MAOA	-1.01477365422148
NA	NA	hsa04519	Cadherin signaling	54/1451	404/9376	0.863699326514319	VIM/MRAS/KRT8/STK3/RRAS/AMOTL2/NFKBIA/NCKAP1L/EGFR/PCDH1/SAV1/AMOTL1/LHFPL2/YWHAG/TMC5/RAC2/KRT18/ADAM10/MAP2K3/VAV1/KRT81/IKBKB/RELA/MYO1F/KRT27/DVL1/LIMD1/MYO1G/GSK3B/YWHAH/TMC4/RRAS2/DVL3/MAPK8/WNT7A/NFKB1/TMC8/MYO1C/APC/PSEN1/FZD1/YWHAZ/LATS2/ANKRD6/CREBBP/FZD7/APH1B/ACTR3C/LATS1/TAOK3/EP300/MAPK1/KRT7/NCSTN	-1.19829503767248
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	3/1451	33/9376	0.587431865171355	OGDH/BCAT2/BCAT1	-1.01584906730665
Organismal Systems	Digestive system	hsa04976	Bile secretion	10/1451	90/9376	0.717972279653879	AQP9/ADCY7/ABCC3/NCEH1/SCARB1/SLC4A2/RXRA/ATP1B1/PRKACA/PRKACB	-1.15031933862505
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	3/1451	34/9376	0.570154457372198	POLR3D/POLR2C/CRCP	-1.07436453466738
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/1451	15/9376	0.430783367792327	ALPP	-0.944021308510447
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	12/1451	108/9376	0.717972279653879	NUP214/KPNA3/DDX19B/XPOT/NXT1/KPNA6/KPNA1/DDX19A/RANGAP1/SUMO3/XPO7/XPO6	-1.26133478005546
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	2/1451	26/9376	0.49705773206807	HES1/HHEX	-1.09880015840984
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	7/1451	70/9376	0.646175051688491	GSTT1/CBR1/GSTA3/PTGS2/GSTK1/SULT1A1/GSTM3	-1.27138082405542
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	3/1451	36/9376	0.538479209740409	HK3/PGM2/PYGB	-1.18710406142097
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	3/1451	37/9376	0.523925717585263	GLUL/IL4I1/ABAT	-1.24149537151893
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	17/1451	154/9376	0.713310121993788	ALPP/NME3/PNPO/PPCS/BCAT2/NADK/BCAT1/ALDH3A2/NMNAT2/COQ6/NADK2/GCLC/EARS2/CMPK2/NQO1/AK9/GUSB	-1.534899237283
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/1451	19/9376	0.340092132467627	OGDH	-1.23200224959558
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	2/1451	31/9376	0.416887130121607	FBP1/PGM2	-1.39143694321604
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	2/1451	31/9376	0.416887130121607	GLUL/CAT	-1.39143694321604
Human Diseases	Substance dependence	hsa05034	Alcoholism	21/1451	191/9376	0.710454245311953	CRH/GNGT1/GNG11/SLC29A3/CREB5/SOS2/ATF4/GNGT2/GNG12/ARAF/PRKACA/PRKACB/ATF6B/CREB3/SOS1/GNB4/MAOA/GNAI2/CALM2/MAPK1/GNG5	-1.72987217848595
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	6/1451	71/9376	0.546063423962105	EGFR/HK3/SCO2/PIK3R1/PIK3CA/MAPK1	-1.64280445579552
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	6/1451	73/9376	0.531102782209718	GSTT1/GSTA3/ALDH3B1/GSTK1/MAOA/GSTM3	-1.72086691258003
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/1451	23/9376	0.28094567464717	GLUL	-1.47730396300162
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/1451	23/9376	0.28094567464717	B4GALT3	-1.47730396300162
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/1451	23/9376	0.28094567464717	ATP1B1	-1.47730396300162
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	5/1451	66/9376	0.489526554309463	HSD17B1/HSD3B1/HSD17B11/STS/CYP19A1	-1.78069685516864
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	6/1451	79/9376	0.490765862041892	GSTT1/CBR1/GSTA3/ALDH3B1/GSTK1/GSTM3	-1.94481971894362
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/1451	30/9376	0.215391683896164	OGDH	-1.84170622029879
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	8/1451	103/9376	0.501883535292032	SLC7A7/COL17A1/SLC38A2/SLC8A1/SLC16A10/ATP1B1/SLC7A8/COL8A2	-2.174999134869
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	5/1451	75/9376	0.430783367792327	GLUL/SDS/SDSL/BCAT2/BCAT1	-2.11769348210537
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/1451	31/9376	0.208443565060803	TMEM208	-1.88882962992135
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	9/1451	116/9376	0.501342712516932	FBP1/SDS/SDSL/OGDH/ME2/HK3/ACOX1/CAT/ACADS	-2.3123063963578
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/1451	36/9376	0.17949306991347	GUSB	-2.11047287508307
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/1451	36/9376	0.17949306991347	POLD4	-2.11047287508307
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/1451	39/9376	0.165685910689357	MTHFR	-2.23397295319495
Organismal Systems	Sensory system	hsa04742	Taste transduction	4/1451	86/9376	0.300546535669065	SCNN1B/PLCB2/PRKACA/PRKACB	-2.78817419320505
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	4/1451	87/9376	0.297091977787812	COX4I1/SLC8A1/MT-CYB/ATP1B1	-2.81833980027422
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	5/1451	103/9376	0.31367720955752	SYMPK/DDX19B/NXT1/DDX19A/PPP2R2D	-2.99679207819086
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/1451	68/9376	0.190051485790733	ALDH1A1/DHRS4L2	-2.86816010795269
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	29/1451	370/9376	0.506461526999087	CSH1/CSH2/CSHL1/CCK/KISS1/GH2/CRH/C5AR1/FPR3/C3AR1/NR3C1/PTGER4/PTAFR/FPR1/NPFFR2/TAC3/P2RY11/P2RX7/S1PR4/HRH1/ADM/P2RX4/OGFR/ADRB1/P2RY2/PPY/LPAR6/OGFRL1/ADORA3	-4.14453310289738
Genetic Information Processing	Transcription	hsa03040	Spliceosome	10/1451	243/9376	0.265915659131066	HSPA6/SART1/SNRNP27/DDX42/HSPA1A/CCDC12/SF3A1/SLU7/HSPA1B/PRPF6	-4.96091832446192
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	3/1451	183/9376	0.105930336342376	SBDS/NXT1/REXO1	-5.22622355523531
Genetic Information Processing	Translation	hsa03010	Ribosome	5/1451	222/9376	0.145534921551462	RPS4Y1/MRPL46/MRPL1/MRPS10/MRPL55	-5.51296277706474
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	10/1451	449/9376	0.143914265409463	RGS2/ARRB2/SLC8A1/ARRB1/CAMK2D/CAMK2G/PRKG1/PRKACA/PRKACB/CALM2	-7.95439900937911