ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0031267 small GTPase binding 87/2783 283/18639 0.307420494699647 2.05893302217273 8.97304437994463e-12 4.88341836699881e-09 GO:0030695 GTPase regulator activity 130/2783 489/18639 0.265848670756646 1.78050785994723 9.64365511730599e-12 4.88341836699881e-09 GO:0060589 nucleoside-triphosphatase regulator activity 130/2783 490/18639 0.26530612244898 1.77687417043713 1.12348582062856e-11 4.88341836699881e-09 GO:0051020 GTPase binding 91/2783 315/18639 0.288888888888889 1.93481854114265 1.26929180298638e-10 4.13789127773561e-08 GO:0005096 GTPase activator activity 80/2783 271/18639 0.29520295202952 1.9771066557234 5.38966283212024e-10 1.40562406661696e-07 GO:0035091 phosphatidylinositol binding 78/2783 284/18639 0.274647887323944 1.83944016235393 3.02655163768762e-08 6.5777055592411e-06 GO:0005543 phospholipid binding 118/2783 497/18639 0.237424547283702 1.59013874840853 1.04220118486876e-07 1.94147192152694e-05 GO:0023023 MHC protein complex binding 19/2783 37/18639 0.513513513513513 3.43923046294588 2.22975534432764e-07 3.63450121125405e-05 GO:0140313 molecular sequestering activity 24/2783 55/18639 0.436363636363636 2.92252311109659 3.01540220199768e-07 4.36898274600553e-05 GO:0140375 immune receptor activity 48/2783 156/18639 0.307692307692308 2.06075347577324 3.80916595936426e-07 4.967152411011e-05 GO:0004674 protein serine/threonine kinase activity 102/2783 433/18639 0.235565819861432 1.57769001667166 1.1082489147248e-06 0.000123303836650889 GO:0023026 MHC class II protein complex binding 15/2783 27/18639 0.555555555555556 3.72080488681279 1.14400271954409e-06 0.000123303836650889 GO:0019902 phosphatase binding 54/2783 190/18639 0.284210526315789 1.90348544735897 1.22925604023126e-06 0.000123303836650889 GO:0005085 guanyl-nucleotide exchange factor activity 62/2783 230/18639 0.269565217391304 1.80539924073177 1.5172276062438e-06 0.000128211077394298 GO:0005126 cytokine receptor binding 71/2783 275/18639 0.258181818181818 1.72915950739882 1.56176422058247e-06 0.000128211077394298 GO:0019787 ubiquitin-like protein transferase activity 110/2783 479/18639 0.22964509394572 1.53803625801447 1.57314205391776e-06 0.000128211077394298 GO:0016755 aminoacyltransferase activity 112/2783 496/18639 0.225806451612903 1.51232714754326 2.96215651454502e-06 0.000227214829115689 GO:0140311 protein sequestering activity 16/2783 33/18639 0.484848484848485 3.24724790121844 5.36710138909588e-06 0.000388816678410057 GO:0019955 cytokine binding 42/2783 144/18639 0.291666666666667 1.95342256557672 8.93422397489675e-06 0.000613169898066598 GO:0004842 ubiquitin-protein transferase activity 101/2783 449/18639 0.224944320712695 1.50655306998344 1.06005148552694e-05 0.000691153568563566 GO:0003712 transcription coregulator activity 109/2783 495/18639 0.22020202020202 1.47479175513671 1.30770730032048e-05 0.00081202396172281 GO:0106310 protein serine kinase activity 84/2783 361/18639 0.232686980609418 1.55840913818863 1.55560437346915e-05 0.000922049137728989 GO:0003779 actin binding 99/2783 443/18639 0.223476297968397 1.49672106282176 1.71419316234353e-05 0.000971872992911288 GO:0005484 SNAP receptor activity 16/2783 36/18639 0.444444444444444 2.97664390945023 2.15061425568871e-05 0.00116850041225753 GO:1901981 phosphatidylinositol phosphate binding 49/2783 185/18639 0.264864864864865 1.77391887036156 3.00516726963565e-05 0.00156749524784195 GO:0046915 transition metal ion transmembrane transporter activity 18/2783 45/18639 0.4 2.67897951850521 3.81683179279042e-05 0.0019142879453072 GO:0044389 ubiquitin-like protein ligase binding 74/2783 322/18639 0.229813664596273 1.53916525131511 7.44431328655794e-05 0.00359532760210057 GO:0140297 DNA-binding transcription factor binding 104/2783 488/18639 0.213114754098361 1.42732515330196 8.19558207162938e-05 0.00381679965050168 GO:0042277 peptide binding 60/2783 249/18639 0.240963855421687 1.61384308343687 8.64882294436669e-05 0.00388898797222557 GO:0042578 phosphoric ester hydrolase activity 81/2783 363/18639 0.223140495867769 1.49447204544712 0.000101421148999084 0.00421837560713817 GO:0038187 pattern recognition receptor activity 18/2783 48/18639 0.375 2.51154329859863 0.000103910755807376 0.00421837560713817 GO:0035591 signaling adaptor activity 36/2783 129/18639 0.27906976744186 1.86905547802689 0.000104053026596922 0.00421837560713817 GO:0003714 transcription corepressor activity 51/2783 204/18639 0.25 1.67436219906576 0.000106753370426043 0.00421837560713817 GO:0001540 amyloid-beta binding 26/2783 83/18639 0.313253012048193 2.09799600846794 0.000121181721187108 0.00464767542435261 GO:0032395 MHC class II receptor activity 7/2783 10/18639 0.7 4.68821415738412 0.000129865090868288 0.00483840224263564 GO:0046332 SMAD binding 25/2783 79/18639 0.316455696202532 2.11944582160222 0.000135494952141526 0.00490792826645974 GO:0035325 Toll-like receptor binding 8/2783 13/18639 0.615384615384615 4.12150695154648 0.00015540087839739 0.00547683095757288 GO:0140030 modification-dependent protein binding 44/2783 173/18639 0.254335260115607 1.70339738170852 0.000203375933372594 0.00697900571362796 GO:0043130 ubiquitin binding 29/2783 100/18639 0.29 1.94226015091628 0.000230457733567248 0.0077055611428639 GO:0140767 enzyme-substrate adaptor activity 37/2783 139/18639 0.266187050359712 1.78277414001246 0.000240541172425296 0.00784164222106464 GO:0001221 transcription coregulator binding 32/2783 115/18639 0.278260869565217 1.86363792591667 0.000259991872580315 0.00826900980109098 GO:0008429 phosphatidylethanolamine binding 9/2783 17/18639 0.529411764705882 3.5457081862569 0.000282427724295855 0.00876870839242368 GO:0019864 IgG binding 7/2783 11/18639 0.636363636363636 4.2620128703492 0.000310905425016794 0.00921410623231591 GO:0140031 phosphorylation-dependent protein binding 7/2783 11/18639 0.636363636363636 4.2620128703492 0.000310905425016794 0.00921410623231591 GO:0002020 protease binding 36/2783 136/18639 0.264705882352941 1.77285409312845 0.000325748608999983 0.00943947080302173 GO:0016791 phosphatase activity 62/2783 273/18639 0.227106227106227 1.52103232735644 0.000382657298168107 0.0108475025393742 GO:0140996 histone H3 kinase activity 77/2783 357/18639 0.215686274509804 1.44454777958614 0.000446752089825845 0.0123949941517639 GO:0031625 ubiquitin protein ligase binding 67/2783 302/18639 0.221854304635762 1.48585784552855 0.00045630493292305 0.0123962840110762 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 11/2783 25/18639 0.44 2.94687747035573 0.000470195019990107 0.0125129450217775 GO:0098641 cadherin binding involved in cell-cell adhesion 9/2783 18/18639 0.5 3.34872439813151 0.000490156101129483 0.0127235930774963 GO:0042605 peptide antigen binding 16/2783 45/18639 0.355555555555556 2.38131512756019 0.000501623379630587 0.0127235930774963 GO:0019903 protein phosphatase binding 37/2783 144/18639 0.256944444444444 1.72087226015092 0.00050738254603513 0.0127235930774963 GO:0141003 histone H2AX kinase activity 76/2783 354/18639 0.214689265536723 1.43787036303952 0.000558971751888411 0.0137528144238205 GO:0035173 histone kinase activity 77/2783 360/18639 0.213888888888889 1.43250988142292 0.000579370537250217 0.0139318131575446 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 75/2783 349/18639 0.214899713467049 1.43927982727715 0.000587614818761465 0.0139318131575446 GO:0031593 polyubiquitin modification-dependent protein binding 19/2783 59/18639 0.322033898305085 2.15680554455928 0.000652523426119702 0.0151944740653588 GO:0019207 kinase regulator activity 63/2783 287/18639 0.219512195121951 1.47017168698457 0.000882750444179549 0.0201948522668444 GO:0004721 phosphoprotein phosphatase activity 42/2783 175/18639 0.24 1.60738771110313 0.00100757050331575 0.0219061311326579 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 25/2783 89/18639 0.280898876404494 1.88130584164692 0.00100795081898733 0.0219061311326579 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 25/2783 89/18639 0.280898876404494 1.88130584164692 0.00100795081898733 0.0219061311326579 GO:0140793 histone H2AXY142 phosphatase activity 25/2783 90/18639 0.277777777777778 1.8604024434064 0.00120092732395614 0.02567228246621 GO:0005131 growth hormone receptor binding 6/2783 10/18639 0.6 4.01846927775782 0.00134434128274893 0.0282745327855581 GO:0003924 GTPase activity 70/2783 331/18639 0.211480362537764 1.41637889951182 0.00137219788465936 0.0284023181205684 GO:0035035 histone acetyltransferase binding 10/2783 24/18639 0.416666666666667 2.79060366510959 0.00141881368245183 0.0289083287799561 GO:0051019 mitogen-activated protein kinase binding 11/2783 28/18639 0.392857142857143 2.6311405985319 0.00147176509785949 0.029525872117058 GO:0141110 transporter inhibitor activity 15/2783 45/18639 0.333333333333333 2.23248293208768 0.00159028178237313 0.0314201127911298 GO:0019887 protein kinase regulator activity 56/2783 255/18639 0.219607843137255 1.47081228466953 0.00163147993139333 0.0317529825453269 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 31/2783 122/18639 0.254098360655738 1.70181075970618 0.00167918769205532 0.0322008933888255 GO:0019209 kinase activator activity 36/2783 148/18639 0.243243243243243 1.62910916665857 0.00173086229633538 0.0327107889046569 GO:0004722 protein serine/threonine phosphatase activity 27/2783 103/18639 0.262135922330097 1.75564191746701 0.00199999737765041 0.0372570940065162 GO:0030295 protein kinase activator activity 34/2783 139/18639 0.244604316546763 1.63822488541686 0.0020700838493119 0.0380195681620101 GO:0004713 protein tyrosine kinase activity 34/2783 140/18639 0.242857142857143 1.62652327909245 0.0023496158093654 0.0418288318851625 GO:0061659 ubiquitin-like protein ligase activity 76/2783 372/18639 0.204301075268817 1.36829599063438 0.00236168733021087 0.0418288318851625 GO:0004679 AMP-activated protein kinase activity 54/2783 248/18639 0.217741935483871 1.45831546370243 0.00237372205483284 0.0418288318851625 GO:0019003 GDP binding 21/2783 75/18639 0.28 1.87528566295365 0.00257041320583795 0.0421712141113249 GO:0032182 ubiquitin-like protein binding 30/2783 120/18639 0.25 1.67436219906576 0.00258087308424379 0.0421712141113249 GO:0016176 superoxide-generating NADPH oxidase activator activity 6/2783 11/18639 0.545454545454545 3.65315388887074 0.00258446431202749 0.0421712141113249 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 6/2783 11/18639 0.545454545454545 3.65315388887074 0.00258446431202749 0.0421712141113249 GO:0047676 arachidonate-CoA ligase activity 6/2783 11/18639 0.545454545454545 3.65315388887074 0.00258446431202749 0.0421712141113249 GO:0001784 phosphotyrosine residue binding 15/2783 47/18639 0.319148936170213 2.13748365838182 0.00258719104977454 0.0421712141113249 GO:0140789 histone phosphatase activity 33/2783 136/18639 0.242647058823529 1.62511625203441 0.00273872420911643 0.0440900786257756 GO:0008200 ion channel inhibitor activity 14/2783 43/18639 0.325581395348837 2.18056472436471 0.00288894092201821 0.0454383174280006 GO:0070412 R-SMAD binding 10/2783 26/18639 0.384615384615385 2.57594184471655 0.00289216284242642 0.0454383174280006 GO:0003713 transcription coactivator activity 55/2783 256/18639 0.21484375 1.43890501482213 0.00295630985360201 0.0458931910606788 GO:0000149 SNARE binding 27/2783 106/18639 0.254716981132075 1.70595393867077 0.00310865694081794 0.0473881347605942 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 23/2783 86/18639 0.267441860465116 1.79117816644244 0.00315309566184367 0.0473881347605942 GO:0004896 cytokine receptor activity 25/2783 96/18639 0.260416666666667 1.7441272906935 0.00316163169031571 0.0473881347605942 GO:0140857 histone H3T45 kinase activity 53/2783 246/18639 0.215447154471545 1.44294628537374 0.00327065382653749 0.0484651430659647 GO:0061578 K63-linked deubiquitinase activity 7/2783 15/18639 0.466666666666667 3.12547610492275 0.00349586462000234 0.0512203085896972 GO:0035403 histone H3T6 kinase activity 53/2783 247/18639 0.214574898785425 1.43710439757871 0.00357279160289983 0.0517657805575709 GO:0016248 channel inhibitor activity 14/2783 44/18639 0.318181818181818 2.1310064351746 0.00366432871650139 0.0525086224870089 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 94/2783 484/18639 0.194214876033058 1.30074418770398 0.00388471917476072 0.0525413484462997 GO:0015245 fatty acid transmembrane transporter activity 8/2783 19/18639 0.421052631578947 2.8199784405318 0.00394692169028222 0.0525413484462997 GO:0005507 copper ion binding 18/2783 63/18639 0.285714285714286 1.91355679893229 0.00398467417152273 0.0525413484462997 GO:0005385 zinc ion transmembrane transporter activity 10/2783 27/18639 0.37037037037037 2.48053659120853 0.00398669000111196 0.0525413484462997 GO:0001222 transcription corepressor binding 15/2783 49/18639 0.306122448979592 2.05023942742746 0.00405114643418979 0.0525413484462997 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 52/2783 243/18639 0.213991769547325 1.43319891936493 0.00410386330372197 0.0525413484462997 GO:0001216 DNA-binding transcription activator activity 95/2783 491/18639 0.193482688391039 1.2958403984623 0.00415488763836968 0.0525413484462997 GO:0004725 protein tyrosine phosphatase activity 25/2783 98/18639 0.255102040816327 1.70853285618955 0.00423974021142057 0.0525413484462997 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 22/2783 83/18639 0.265060240963855 1.77522739178056 0.0043077419259003 0.0525413484462997 GO:0030165 PDZ domain binding 22/2783 83/18639 0.265060240963855 1.77522739178056 0.0043077419259003 0.0525413484462997 GO:0004715 non-membrane spanning protein tyrosine kinase activity 14/2783 45/18639 0.311111111111111 2.08365073661516 0.00460099507384965 0.0525413484462997 GO:0001786 phosphatidylserine binding 17/2783 59/18639 0.288135593220339 1.92977338197409 0.00460502293597399 0.0525413484462997 GO:0045309 protein phosphorylated amino acid binding 17/2783 59/18639 0.288135593220339 1.92977338197409 0.00460502293597399 0.0525413484462997 GO:0004676 3-phosphoinositide-dependent protein kinase activity 52/2783 245/18639 0.212244897959184 1.4214993363497 0.00487538586043119 0.0525413484462997 GO:0004711 ribosomal protein S6 kinase activity 52/2783 245/18639 0.212244897959184 1.4214993363497 0.00487538586043119 0.0525413484462997 GO:0035175 histone H3S10 kinase activity 52/2783 245/18639 0.212244897959184 1.4214993363497 0.00487538586043119 0.0525413484462997 GO:0035979 histone H2AXS139 kinase activity 52/2783 245/18639 0.212244897959184 1.4214993363497 0.00487538586043119 0.0525413484462997 GO:0044022 histone H3S28 kinase activity 52/2783 245/18639 0.212244897959184 1.4214993363497 0.00487538586043119 0.0525413484462997 GO:0044023 histone H4S1 kinase activity 52/2783 245/18639 0.212244897959184 1.4214993363497 0.00487538586043119 0.0525413484462997 GO:0044024 histone H2AS1 kinase activity 52/2783 245/18639 0.212244897959184 1.4214993363497 0.00487538586043119 0.0525413484462997 GO:0044025 histone H2BS14 kinase activity 52/2783 245/18639 0.212244897959184 1.4214993363497 0.00487538586043119 0.0525413484462997 GO:0072354 histone H3T3 kinase activity 52/2783 245/18639 0.212244897959184 1.4214993363497 0.00487538586043119 0.0525413484462997 GO:0072371 histone H2AS121 kinase activity 52/2783 245/18639 0.212244897959184 1.4214993363497 0.00487538586043119 0.0525413484462997 GO:0072518 Rho-dependent protein serine/threonine kinase activity 52/2783 245/18639 0.212244897959184 1.4214993363497 0.00487538586043119 0.0525413484462997 GO:0140823 histone H2BS36 kinase activity 52/2783 245/18639 0.212244897959184 1.4214993363497 0.00487538586043119 0.0525413484462997 GO:0140855 histone H3S57 kinase activity 52/2783 245/18639 0.212244897959184 1.4214993363497 0.00487538586043119 0.0525413484462997 GO:0140995 histone H2A kinase activity 52/2783 245/18639 0.212244897959184 1.4214993363497 0.00487538586043119 0.0525413484462997 GO:0140997 histone H4 kinase activity 52/2783 245/18639 0.212244897959184 1.4214993363497 0.00487538586043119 0.0525413484462997 GO:0140998 histone H2B kinase activity 52/2783 245/18639 0.212244897959184 1.4214993363497 0.00487538586043119 0.0525413484462997 GO:1990244 histone H2AT120 kinase activity 52/2783 245/18639 0.212244897959184 1.4214993363497 0.00487538586043119 0.0525413484462997 GO:0032813 tumor necrosis factor receptor superfamily binding 15/2783 50/18639 0.3 2.00923463887891 0.00500318411337135 0.0534766564248872 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 13/2783 41/18639 0.317073170731707 2.12358132564437 0.0051998149992762 0.0546819254762594 GO:0042169 SH2 domain binding 13/2783 41/18639 0.317073170731707 2.12358132564437 0.0051998149992762 0.0546819254762594 GO:0004677 DNA-dependent protein kinase activity 52/2783 246/18639 0.211382113821138 1.41572088376292 0.00530552022003162 0.0553471869353698 GO:0046966 nuclear thyroid hormone receptor binding 10/2783 28/18639 0.357142857142857 2.39194599866537 0.00538387050291892 0.0556634393528196 GO:0005324 long-chain fatty acid transmembrane transporter activity 7/2783 16/18639 0.4375 2.93013384836507 0.00542120920077308 0.0556634393528196 GO:0038024 cargo receptor activity 18/2783 65/18639 0.276923076923077 1.85467812819591 0.00571319756424805 0.058203200185777 GO:0035402 histone H3T11 kinase activity 52/2783 247/18639 0.210526315789474 1.4099892202659 0.00576758118460005 0.0583017508892905 GO:0140416 transcription regulator inhibitor activity 11/2783 33/18639 0.333333333333333 2.23248293208768 0.00649576333765623 0.065157503017721 GO:0019208 phosphatase regulator activity 28/2783 117/18639 0.239316239316239 1.60280825893474 0.00670247412522941 0.0667177577045737 GO:0016209 antioxidant activity 22/2783 86/18639 0.255813953488372 1.71330085485798 0.00677816847796784 0.0669600886005307 GO:0051861 glycolipid binding 10/2783 29/18639 0.344827586206897 2.30946510215966 0.0071360862385289 0.0699658380078323 GO:0016504 peptidase activator activity 16/2783 57/18639 0.280701754385965 1.8799856270212 0.0077291803516076 0.0752153073022113 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 7/2783 17/18639 0.411764705882353 2.75777303375536 0.00804256434840549 0.0767026314587799 GO:0005123 death receptor binding 8/2783 21/18639 0.380952380952381 2.55140906524306 0.00805848198608347 0.0767026314587799 GO:0051010 microtubule plus-end binding 8/2783 21/18639 0.380952380952381 2.55140906524306 0.00805848198608347 0.0767026314587799 GO:0140693 molecular condensate scaffold activity 14/2783 48/18639 0.291666666666667 1.95342256557672 0.00861658533838027 0.0814204875452744 GO:0019838 growth factor binding 31/2783 136/18639 0.227941176470588 1.52662435797172 0.00943194822433312 0.0884838883779164 GO:0005381 iron ion transmembrane transporter activity 5/2783 10/18639 0.5 3.34872439813151 0.0096604866795921 0.088713201621043 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 5/2783 10/18639 0.5 3.34872439813151 0.0096604866795921 0.088713201621043 GO:0045322 unmethylated CpG binding 5/2783 10/18639 0.5 3.34872439813151 0.0096604866795921 0.088713201621043 GO:0061630 ubiquitin protein ligase activity 69/2783 353/18639 0.195467422096317 1.30913305082762 0.0103842621938986 0.0946928524534533 GO:0016922 nuclear receptor binding 31/2783 137/18639 0.226277372262774 1.51548111448287 0.0104910959119161 0.0950027018690178 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 15/2783 54/18639 0.277777777777778 1.8604024434064 0.0107646414970928 0.0968075345669586 GO:0016530 metallochaperone activity 6/2783 14/18639 0.428571428571429 2.87033519839844 0.0112432792701156 0.0983975581760455 GO:0019763 immunoglobulin receptor activity 6/2783 14/18639 0.428571428571429 2.87033519839844 0.0112432792701156 0.0983975581760455 GO:0044548 S100 protein binding 6/2783 14/18639 0.428571428571429 2.87033519839844 0.0112432792701156 0.0983975581760455 GO:0061665 SUMO ligase activity 6/2783 14/18639 0.428571428571429 2.87033519839844 0.0112432792701156 0.0983975581760455 GO:0016854 racemase and epimerase activity 7/2783 18/18639 0.388888888888889 2.60456342076895 0.0114898353786606 0.0985706929853512 GO:0017075 syntaxin-1 binding 7/2783 18/18639 0.388888888888889 2.60456342076895 0.0114898353786606 0.0985706929853512 GO:0030228 lipoprotein particle receptor activity 7/2783 18/18639 0.388888888888889 2.60456342076895 0.0114898353786606 0.0985706929853512 GO:1902936 phosphatidylinositol bisphosphate binding 26/2783 111/18639 0.234234234234234 1.56877179011566 0.0116121010502063 0.0989684952252877 GO:0048306 calcium-dependent protein binding 20/2783 80/18639 0.25 1.67436219906576 0.0123640023352343 0.104692591202243 GO:0097110 scaffold protein binding 18/2783 70/18639 0.257142857142857 1.72220111903906 0.0127861300169162 0.107060128598498 GO:0098632 cell-cell adhesion mediator activity 15/2783 55/18639 0.272727272727273 1.82657694443537 0.0128078067955259 0.107060128598498 GO:0072341 modified amino acid binding 22/2783 91/18639 0.241758241758242 1.6191634452504 0.0133837856298288 0.110675702823763 GO:0050660 flavin adenine dinucleotide binding 21/2783 86/18639 0.244186046511628 1.63542354327353 0.0137933598001375 0.110675702823763 GO:0001618 virus receptor activity 20/2783 81/18639 0.246913580246914 1.65369106080569 0.0141739588739022 0.110675702823763 GO:0033192 calmodulin-dependent protein phosphatase activity 20/2783 81/18639 0.246913580246914 1.65369106080569 0.0141739588739022 0.110675702823763 GO:0140791 histone H2AXS140 phosphatase activity 20/2783 81/18639 0.246913580246914 1.65369106080569 0.0141739588739022 0.110675702823763 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 20/2783 81/18639 0.246913580246914 1.65369106080569 0.0141739588739022 0.110675702823763 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 20/2783 81/18639 0.246913580246914 1.65369106080569 0.0141739588739022 0.110675702823763 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 20/2783 81/18639 0.246913580246914 1.65369106080569 0.0141739588739022 0.110675702823763 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 20/2783 81/18639 0.246913580246914 1.65369106080569 0.0141739588739022 0.110675702823763 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 20/2783 81/18639 0.246913580246914 1.65369106080569 0.0141739588739022 0.110675702823763 GO:1990439 MAP kinase serine/threonine phosphatase activity 20/2783 81/18639 0.246913580246914 1.65369106080569 0.0141739588739022 0.110675702823763 GO:0019905 syntaxin binding 16/2783 61/18639 0.262295081967213 1.75670788098702 0.0151376486101299 0.117263307916811 GO:0005114 type II transforming growth factor beta receptor binding 5/2783 11/18639 0.454545454545455 3.04429490739228 0.0155571719858959 0.117263307916811 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 5/2783 11/18639 0.454545454545455 3.04429490739228 0.0155571719858959 0.117263307916811 GO:0034713 type I transforming growth factor beta receptor binding 5/2783 11/18639 0.454545454545455 3.04429490739228 0.0155571719858959 0.117263307916811 GO:0042608 T cell receptor binding 5/2783 11/18639 0.454545454545455 3.04429490739228 0.0155571719858959 0.117263307916811 GO:0050786 RAGE receptor binding 5/2783 11/18639 0.454545454545455 3.04429490739228 0.0155571719858959 0.117263307916811 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 20/2783 82/18639 0.24390243902439 1.63352409664952 0.01618652396694 0.119532524976141 GO:0033549 MAP kinase phosphatase activity 20/2783 82/18639 0.24390243902439 1.63352409664952 0.01618652396694 0.119532524976141 GO:0140272 exogenous protein binding 20/2783 82/18639 0.24390243902439 1.63352409664952 0.01618652396694 0.119532524976141 GO:0043394 proteoglycan binding 11/2783 37/18639 0.297297297297297 1.99113342591603 0.0162860407971035 0.119532524976141 GO:0004467 long-chain fatty acid-CoA ligase activity 6/2783 15/18639 0.4 2.67897951850521 0.0164082223701911 0.119532524976141 GO:0005041 low-density lipoprotein particle receptor activity 6/2783 15/18639 0.4 2.67897951850521 0.0164082223701911 0.119532524976141 GO:0019789 SUMO transferase activity 9/2783 28/18639 0.321428571428571 2.15275139879883 0.0171396336807983 0.123481117788735 GO:0036408 histone H3K14 acetyltransferase activity 9/2783 28/18639 0.321428571428571 2.15275139879883 0.0171396336807983 0.123481117788735 GO:0030159 signaling receptor complex adaptor activity 14/2783 52/18639 0.269230769230769 1.80315929130158 0.017769672737153 0.127316776094767 GO:0017124 SH3 domain binding 26/2783 115/18639 0.226086956521739 1.51420581480729 0.018137513448448 0.129242172332111 GO:0019239 deaminase activity 10/2783 33/18639 0.303030303030303 2.02952993826152 0.0188101925797456 0.133307016978197 GO:0042625 ATPase-coupled ion transmembrane transporter activity 8/2783 24/18639 0.333333333333333 2.23248293208768 0.0192895984497035 0.13379593818305 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 8/2783 24/18639 0.333333333333333 2.23248293208768 0.0192895984497035 0.13379593818305 GO:0046961 proton-transporting ATPase activity, rotational mechanism 8/2783 24/18639 0.333333333333333 2.23248293208768 0.0192895984497035 0.13379593818305 GO:0050431 transforming growth factor beta binding 8/2783 24/18639 0.333333333333333 2.23248293208768 0.0192895984497035 0.13379593818305 GO:0045296 cadherin binding 64/2783 334/18639 0.191616766467066 1.28334348191866 0.0197661277654368 0.136375823312855 GO:0048156 tau protein binding 12/2783 43/18639 0.27906976744186 1.86905547802689 0.0205617713204252 0.14111868316755 GO:0017018 myosin phosphatase activity 20/2783 84/18639 0.238095238095238 1.59463066577691 0.0208768794531899 0.14253115605738 GO:0005178 integrin binding 34/2783 161/18639 0.211180124223602 1.41436806877604 0.021251907127752 0.144331412391172 GO:0016004 phospholipase activator activity 7/2783 20/18639 0.35 2.34410707869206 0.0213619345026811 0.144331412391172 GO:0010484 histone H3 acetyltransferase activity 9/2783 29/18639 0.310344827586207 2.0785185919437 0.0216412300298196 0.144718789532742 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 9/2783 29/18639 0.310344827586207 2.0785185919437 0.0216412300298196 0.144718789532742 GO:0070851 growth factor receptor binding 30/2783 139/18639 0.215827338129496 1.44549254595605 0.0220607271467477 0.146740925796693 GO:0008013 beta-catenin binding 24/2783 106/18639 0.226415094339623 1.51640350104069 0.0221686828082428 0.146740925796693 GO:0005149 interleukin-1 receptor binding 6/2783 16/18639 0.375 2.51154329859863 0.023000430271842 0.148478025121198 GO:0005159 insulin-like growth factor receptor binding 6/2783 16/18639 0.375 2.51154329859863 0.023000430271842 0.148478025121198 GO:0005521 lamin binding 6/2783 16/18639 0.375 2.51154329859863 0.023000430271842 0.148478025121198 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 6/2783 16/18639 0.375 2.51154329859863 0.023000430271842 0.148478025121198 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 6/2783 16/18639 0.375 2.51154329859863 0.023000430271842 0.148478025121198 GO:0052866 phosphatidylinositol phosphate phosphatase activity 10/2783 34/18639 0.294117647058824 1.96983788125383 0.0231764892535336 0.148877546732058 GO:0035014 phosphatidylinositol 3-kinase regulator activity 5/2783 12/18639 0.416666666666667 2.79060366510959 0.0234415172353981 0.149841855269407 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 15/2783 59/18639 0.254237288135593 1.7027412193889 0.0241229713933849 0.153445632668165 GO:0019888 protein phosphatase regulator activity 24/2783 107/18639 0.224299065420561 1.50223150570386 0.0246557514778211 0.155889903358874 GO:0004709 MAP kinase kinase kinase activity 8/2783 25/18639 0.32 2.14318361480417 0.0247463266835023 0.155889903358874 GO:0051015 actin filament binding 42/2783 209/18639 0.200956937799043 1.3458988011629 0.0255089488909851 0.159921487278099 GO:0001664 G protein-coupled receptor binding 57/2783 297/18639 0.191919191919192 1.28536896089896 0.025801304746227 0.160980389421435 GO:0001968 fibronectin binding 9/2783 30/18639 0.3 2.00923463887891 0.0269310924020974 0.163676920962888 GO:0035925 mRNA 3'-UTR AU-rich region binding 9/2783 30/18639 0.3 2.00923463887891 0.0269310924020974 0.163676920962888 GO:0043995 histone H4K5 acetyltransferase activity 9/2783 30/18639 0.3 2.00923463887891 0.0269310924020974 0.163676920962888 GO:0043996 histone H4K8 acetyltransferase activity 9/2783 30/18639 0.3 2.00923463887891 0.0269310924020974 0.163676920962888 GO:0043997 histone H4K12 acetyltransferase activity 9/2783 30/18639 0.3 2.00923463887891 0.0269310924020974 0.163676920962888 GO:0030246 carbohydrate binding 54/2783 280/18639 0.192857142857143 1.2916508392793 0.0269866089010896 0.163676920962888 GO:0098631 cell adhesion mediator activity 18/2783 76/18639 0.236842105263158 1.58623787279914 0.0288198351702301 0.171174742365829 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 11/2783 40/18639 0.275 1.84179841897233 0.0288791743255233 0.171174742365829 GO:0061791 GTPase motor activity 11/2783 40/18639 0.275 1.84179841897233 0.0288791743255233 0.171174742365829 GO:0071949 FAD binding 11/2783 40/18639 0.275 1.84179841897233 0.0288791743255233 0.171174742365829 GO:1990606 membrane scission GTPase motor activity 11/2783 40/18639 0.275 1.84179841897233 0.0288791743255233 0.171174742365829 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 6/2783 17/18639 0.352941176470588 2.3638054575046 0.0311592662300801 0.176097917194561 GO:0016805 dipeptidase activity 6/2783 17/18639 0.352941176470588 2.3638054575046 0.0311592662300801 0.176097917194561 GO:0030169 low-density lipoprotein particle binding 6/2783 17/18639 0.352941176470588 2.3638054575046 0.0311592662300801 0.176097917194561 GO:0036041 long-chain fatty acid binding 6/2783 17/18639 0.352941176470588 2.3638054575046 0.0311592662300801 0.176097917194561 GO:0005160 transforming growth factor beta receptor binding 8/2783 26/18639 0.307692307692308 2.06075347577324 0.0311952598711223 0.176097917194561 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 8/2783 26/18639 0.307692307692308 2.06075347577324 0.0311952598711223 0.176097917194561 GO:0008157 protein phosphatase 1 binding 8/2783 26/18639 0.307692307692308 2.06075347577324 0.0311952598711223 0.176097917194561 GO:0019865 immunoglobulin binding 8/2783 26/18639 0.307692307692308 2.06075347577324 0.0311952598711223 0.176097917194561 GO:0043548 phosphatidylinositol 3-kinase binding 8/2783 26/18639 0.307692307692308 2.06075347577324 0.0311952598711223 0.176097917194561 GO:0050681 nuclear androgen receptor binding 8/2783 26/18639 0.307692307692308 2.06075347577324 0.0311952598711223 0.176097917194561 GO:0050750 low-density lipoprotein particle receptor binding 8/2783 26/18639 0.307692307692308 2.06075347577324 0.0311952598711223 0.176097917194561 GO:0035401 histone H3Y41 kinase activity 25/2783 115/18639 0.217391304347826 1.4559671296224 0.0316708766208799 0.177248167869645 GO:0140801 histone H2AXY142 kinase activity 25/2783 115/18639 0.217391304347826 1.4559671296224 0.0316708766208799 0.177248167869645 GO:0005164 tumor necrosis factor receptor binding 9/2783 31/18639 0.290322580645161 1.94442061826991 0.0330692492078234 0.183569492019123 GO:0004197 cysteine-type endopeptidase activity 20/2783 88/18639 0.227272727272727 1.52214745369614 0.0333200374976498 0.183569492019123 GO:0017154 semaphorin receptor activity 5/2783 13/18639 0.384615384615385 2.57594184471655 0.0335042477764964 0.183569492019123 GO:0032396 inhibitory MHC class I receptor activity 5/2783 13/18639 0.384615384615385 2.57594184471655 0.0335042477764964 0.183569492019123 GO:0043560 insulin receptor substrate binding 5/2783 13/18639 0.384615384615385 2.57594184471655 0.0335042477764964 0.183569492019123 GO:0001727 lipid kinase activity 11/2783 41/18639 0.268292682926829 1.79687650631447 0.0343110996695844 0.185962653838721 GO:0032931 histone H3K56 acetyltransferase activity 7/2783 22/18639 0.318181818181818 2.1310064351746 0.035937568073127 0.185962653838721 GO:0043992 histone H3K9 acetyltransferase activity 7/2783 22/18639 0.318181818181818 2.1310064351746 0.035937568073127 0.185962653838721 GO:0043993 histone H3K18 acetyltransferase activity 7/2783 22/18639 0.318181818181818 2.1310064351746 0.035937568073127 0.185962653838721 GO:0043994 histone H3K23 acetyltransferase activity 7/2783 22/18639 0.318181818181818 2.1310064351746 0.035937568073127 0.185962653838721 GO:0043999 histone H2AK5 acetyltransferase activity 7/2783 22/18639 0.318181818181818 2.1310064351746 0.035937568073127 0.185962653838721 GO:0044012 histone H2AK9 acetyltransferase activity 7/2783 22/18639 0.318181818181818 2.1310064351746 0.035937568073127 0.185962653838721 GO:0044014 histone H2BK5 acetyltransferase activity 7/2783 22/18639 0.318181818181818 2.1310064351746 0.035937568073127 0.185962653838721 GO:0044015 histone H2BK12 acetyltransferase activity 7/2783 22/18639 0.318181818181818 2.1310064351746 0.035937568073127 0.185962653838721 GO:0044016 histone H3K4 acetyltransferase activity 7/2783 22/18639 0.318181818181818 2.1310064351746 0.035937568073127 0.185962653838721 GO:0044017 histone H3K27 acetyltransferase activity 7/2783 22/18639 0.318181818181818 2.1310064351746 0.035937568073127 0.185962653838721 GO:0044018 histone H3K36 acetyltransferase activity 7/2783 22/18639 0.318181818181818 2.1310064351746 0.035937568073127 0.185962653838721 GO:0046972 histone H4K16 acetyltransferase activity 7/2783 22/18639 0.318181818181818 2.1310064351746 0.035937568073127 0.185962653838721 GO:0140908 histone H3K122 acetyltransferase activity 7/2783 22/18639 0.318181818181818 2.1310064351746 0.035937568073127 0.185962653838721 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 27/2783 128/18639 0.2109375 1.41274310546173 0.0373663511385811 0.192591786105572 GO:0004683 calcium/calmodulin-dependent protein kinase activity 8/2783 27/18639 0.296296296296296 1.98442927296682 0.0387044238099191 0.197150658781776 GO:0005044 scavenger receptor activity 8/2783 27/18639 0.296296296296296 1.98442927296682 0.0387044238099191 0.197150658781776 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 8/2783 27/18639 0.296296296296296 1.98442927296682 0.0387044238099191 0.197150658781776 GO:0004860 protein kinase inhibitor activity 19/2783 84/18639 0.226190476190476 1.51489913248807 0.039046716005703 0.198120302223489 GO:0005504 fatty acid binding 12/2783 47/18639 0.25531914893617 1.70998692670545 0.0398254937513341 0.199626916559459 GO:0061733 protein-lysine-acetyltransferase activity 12/2783 47/18639 0.25531914893617 1.70998692670545 0.0398254937513341 0.199626916559459 GO:0071813 lipoprotein particle binding 9/2783 32/18639 0.28125 1.88365747394898 0.0401090890633269 0.199626916559459 GO:0071814 protein-lipid complex binding 9/2783 32/18639 0.28125 1.88365747394898 0.0401090890633269 0.199626916559459 GO:0140142 nucleocytoplasmic carrier activity 9/2783 32/18639 0.28125 1.88365747394898 0.0401090890633269 0.199626916559459 GO:0004402 histone acetyltransferase activity 11/2783 42/18639 0.261904761904762 1.7540937323546 0.0404244723706022 0.200210307412547 GO:0004706 JUN kinase kinase kinase activity 6/2783 18/18639 0.333333333333333 2.23248293208768 0.0409939816557898 0.200210307412547 GO:0032393 MHC class I receptor activity 6/2783 18/18639 0.333333333333333 2.23248293208768 0.0409939816557898 0.200210307412547 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 6/2783 18/18639 0.333333333333333 2.23248293208768 0.0409939816557898 0.200210307412547 GO:1990381 ubiquitin-specific protease binding 6/2783 18/18639 0.333333333333333 2.23248293208768 0.0409939816557898 0.200210307412547 GO:0008017 microtubule binding 52/2783 276/18639 0.188405797101449 1.26183817900608 0.0430870871678119 0.209647618159801 GO:0005544 calcium-dependent phospholipid binding 13/2783 53/18639 0.245283018867925 1.64277045946074 0.044777895056776 0.215152006718779 GO:0034212 protein N-acetyltransferase activity 13/2783 53/18639 0.245283018867925 1.64277045946074 0.044777895056776 0.215152006718779 GO:0140296 general transcription initiation factor binding 13/2783 53/18639 0.245283018867925 1.64277045946074 0.044777895056776 0.215152006718779 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 7/2783 23/18639 0.304347826086957 2.03835398147136 0.0452083204301728 0.215152006718779 GO:0005158 insulin receptor binding 7/2783 23/18639 0.304347826086957 2.03835398147136 0.0452083204301728 0.215152006718779 GO:0044013 histone H2B acetyltransferase activity 7/2783 23/18639 0.304347826086957 2.03835398147136 0.0452083204301728 0.215152006718779 GO:0005545 1-phosphatidylinositol binding 5/2783 14/18639 0.357142857142857 2.39194599866537 0.0458714525022635 0.216725992981709 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 5/2783 14/18639 0.357142857142857 2.39194599866537 0.0458714525022635 0.216725992981709 GO:0097718 disordered domain specific binding 8/2783 28/18639 0.285714285714286 1.91355679893229 0.0473303398615675 0.22281141942052 GO:0019956 chemokine binding 9/2783 33/18639 0.272727272727273 1.82657694443537 0.0480961752446699 0.224273685183899 GO:0003725 double-stranded RNA binding 17/2783 75/18639 0.226666666666667 1.51808839381962 0.0481711779241336 0.224273685183899 GO:0001217 DNA-binding transcription repressor activity 52/2783 278/18639 0.18705035971223 1.25276020649524 0.048209134035404 0.224273685183899 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 4/2783 10/18639 0.4 2.67897951850521 0.0491888604007631 0.224273685183899 GO:0008140 cAMP response element binding protein binding 4/2783 10/18639 0.4 2.67897951850521 0.0491888604007631 0.224273685183899 GO:0008641 ubiquitin-like modifier activating enzyme activity 4/2783 10/18639 0.4 2.67897951850521 0.0491888604007631 0.224273685183899 GO:0015279 store-operated calcium channel activity 4/2783 10/18639 0.4 2.67897951850521 0.0491888604007631 0.224273685183899 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 4/2783 10/18639 0.4 2.67897951850521 0.0491888604007631 0.224273685183899 GO:1905394 retromer complex binding 4/2783 10/18639 0.4 2.67897951850521 0.0491888604007631 0.224273685183899 GO:0008028 monocarboxylic acid transmembrane transporter activity 16/2783 70/18639 0.228571428571429 1.53084543914583 0.0506262115455482 0.230022926325418 GO:0015485 cholesterol binding 13/2783 54/18639 0.240740740740741 1.61234878428554 0.0512144543188148 0.231887668165745 GO:0140036 ubiquitin-modified protein reader activity 6/2783 19/18639 0.315789473684211 2.11498383039885 0.0525804954829783 0.237249017680982 GO:0016763 pentosyltransferase activity 12/2783 49/18639 0.244897959183673 1.64019154194197 0.0531170537110959 0.238843579445755 GO:0001223 transcription coactivator binding 11/2783 44/18639 0.25 1.67436219906576 0.0548229101109285 0.245666923658594 GO:0042826 histone deacetylase binding 26/2783 127/18639 0.204724409448819 1.37113124962865 0.0555451256742152 0.247011792927975 GO:0001091 RNA polymerase II general transcription initiation factor binding 7/2783 24/18639 0.291666666666667 1.95342256557672 0.0558807353633072 0.247011792927975 GO:0043998 histone H2A acetyltransferase activity 7/2783 24/18639 0.291666666666667 1.95342256557672 0.0558807353633072 0.247011792927975 GO:0060229 lipase activator activity 7/2783 24/18639 0.291666666666667 1.95342256557672 0.0558807353633072 0.247011792927975 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 10/2783 39/18639 0.256410256410256 1.71729456314437 0.0562038352002593 0.247600679395737 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 9/2783 34/18639 0.264705882352941 1.77285409312845 0.0570672622014789 0.249717147351438 GO:0051427 hormone receptor binding 9/2783 34/18639 0.264705882352941 1.77285409312845 0.0570672622014789 0.249717147351438 GO:0015631 tubulin binding 69/2783 385/18639 0.179220779220779 1.20032199205753 0.0582738531076707 0.254144162048169 GO:0017081 chloride channel regulator activity 5/2783 15/18639 0.333333333333333 2.23248293208768 0.0606030675682995 0.261676821553187 GO:0047372 monoacylglycerol lipase activity 5/2783 15/18639 0.333333333333333 2.23248293208768 0.0606030675682995 0.261676821553187 GO:0120283 protein serine/threonine kinase binding 5/2783 15/18639 0.333333333333333 2.23248293208768 0.0606030675682995 0.261676821553187 GO:0031406 carboxylic acid binding 36/2783 187/18639 0.192513368983957 1.28934843136614 0.0625548952863471 0.26829597572298 GO:1990782 protein tyrosine kinase binding 24/2783 117/18639 0.205128205128205 1.37383565051549 0.0626407387479493 0.26829597572298 GO:0015026 coreceptor activity 14/2783 61/18639 0.229508196721311 1.53711939586365 0.0627532765302983 0.26829597572298 GO:0005518 collagen binding 16/2783 72/18639 0.222222222222222 1.48832195472512 0.063140652190026 0.269069968809784 GO:0033218 amide binding 46/2783 247/18639 0.186234817813765 1.24729815638907 0.0637248835565324 0.269927790995883 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 43/2783 229/18639 0.187772925764192 1.25759955563018 0.0637559506339968 0.269927790995883 GO:0032451 demethylase activity 10/2783 40/18639 0.25 1.67436219906576 0.065312055491838 0.273627872265606 GO:0019001 guanyl nucleotide binding 71/2783 400/18639 0.1775 1.18879716133669 0.0656261714699371 0.273627872265606 GO:0032561 guanyl ribonucleotide binding 71/2783 400/18639 0.1775 1.18879716133669 0.0656261714699371 0.273627872265606 GO:0170055 lipid transmembrane transporter activity 13/2783 56/18639 0.232142857142857 1.55476489913249 0.0659214122658598 0.273627872265606 GO:0001614 purinergic nucleotide receptor activity 6/2783 20/18639 0.3 2.00923463887891 0.0659598787602485 0.273627872265606 GO:0016502 nucleotide receptor activity 6/2783 20/18639 0.3 2.00923463887891 0.0659598787602485 0.273627872265606 GO:0010485 histone H4 acetyltransferase activity 9/2783 35/18639 0.257142857142857 1.72220111903906 0.0670495321430792 0.273627872265606 GO:0061631 ubiquitin conjugating enzyme activity 9/2783 35/18639 0.257142857142857 1.72220111903906 0.0670495321430792 0.273627872265606 GO:0032452 histone demethylase activity 8/2783 30/18639 0.266666666666667 1.78598634567014 0.0680932401490359 0.273627872265606 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 4/2783 11/18639 0.363636363636364 2.43543592591383 0.0684069680664015 0.273627872265606 GO:0008432 JUN kinase binding 4/2783 11/18639 0.363636363636364 2.43543592591383 0.0684069680664015 0.273627872265606 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 4/2783 11/18639 0.363636363636364 2.43543592591383 0.0684069680664015 0.273627872265606 GO:0019206 nucleoside kinase activity 4/2783 11/18639 0.363636363636364 2.43543592591383 0.0684069680664015 0.273627872265606 GO:0032050 clathrin heavy chain binding 4/2783 11/18639 0.363636363636364 2.43543592591383 0.0684069680664015 0.273627872265606 GO:0032794 GTPase activating protein binding 4/2783 11/18639 0.363636363636364 2.43543592591383 0.0684069680664015 0.273627872265606 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 4/2783 11/18639 0.363636363636364 2.43543592591383 0.0684069680664015 0.273627872265606 GO:0097493 structural molecule activity conferring elasticity 4/2783 11/18639 0.363636363636364 2.43543592591383 0.0684069680664015 0.273627872265606 GO:0140537 transcription regulator activator activity 4/2783 11/18639 0.363636363636364 2.43543592591383 0.0684069680664015 0.273627872265606 GO:0022804 active transmembrane transporter activity 80/2783 457/18639 0.175054704595186 1.17241992057121 0.0693797156373692 0.276670181012628 GO:0016298 lipase activity 26/2783 130/18639 0.2 1.33948975925261 0.070253284844963 0.279299644627536 GO:0043177 organic acid binding 36/2783 189/18639 0.19047619047619 1.27570453262153 0.0709646236413207 0.2812701192349 GO:0019210 kinase inhibitor activity 19/2783 90/18639 0.211111111111111 1.41390585698886 0.0713004066246804 0.281744637086616 GO:0016407 acetyltransferase activity 20/2783 96/18639 0.208333333333333 1.3953018325548 0.0733931229069024 0.288810343566721 GO:0005525 GTP binding 67/2783 378/18639 0.177248677248677 1.18711394007837 0.0735314678406068 0.288810343566721 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 49/2783 268/18639 0.182835820895522 1.22453354857048 0.0742181688747436 0.28901928795404 GO:0004601 peroxidase activity 13/2783 57/18639 0.228070175438596 1.52748832195473 0.0742225083078358 0.28901928795404 GO:1990841 promoter-specific chromatin binding 15/2783 68/18639 0.220588235294118 1.47737841094037 0.0742495870127327 0.28901928795404 GO:0008238 exopeptidase activity 21/2783 102/18639 0.205882352941176 1.37888651687768 0.075229710529143 0.289697116293105 GO:0001530 lipopolysaccharide binding 10/2783 41/18639 0.24390243902439 1.63352409664952 0.0753123638215972 0.289697116293105 GO:0016877 ligase activity, forming carbon-sulfur bonds 10/2783 41/18639 0.24390243902439 1.63352409664952 0.0753123638215972 0.289697116293105 GO:0061650 ubiquitin-like protein conjugating enzyme activity 10/2783 41/18639 0.24390243902439 1.63352409664952 0.0753123638215972 0.289697116293105 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 5/2783 16/18639 0.3125 2.0929527488322 0.0776951754303257 0.295377576563104 GO:0022858 alanine transmembrane transporter activity 5/2783 16/18639 0.3125 2.0929527488322 0.0776951754303257 0.295377576563104 GO:0055102 lipase inhibitor activity 5/2783 16/18639 0.3125 2.0929527488322 0.0776951754303257 0.295377576563104 GO:0070411 I-SMAD binding 5/2783 16/18639 0.3125 2.0929527488322 0.0776951754303257 0.295377576563104 GO:0016409 palmitoyltransferase activity 9/2783 36/18639 0.25 1.67436219906576 0.0780600608647871 0.295902091185123 GO:0070273 phosphatidylinositol-4-phosphate binding 8/2783 31/18639 0.258064516129032 1.72837388290659 0.0802754978677187 0.301669306108084 GO:0070325 lipoprotein particle receptor binding 8/2783 31/18639 0.258064516129032 1.72837388290659 0.0802754978677187 0.301669306108084 GO:0140457 protein demethylase activity 8/2783 31/18639 0.258064516129032 1.72837388290659 0.0802754978677187 0.301669306108084 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 6/2783 21/18639 0.285714285714286 1.91355679893229 0.081138365959956 0.303809599807286 GO:0008198 ferrous iron binding 7/2783 26/18639 0.269230769230769 1.80315929130158 0.0815439876783359 0.303809599807286 GO:0052742 phosphatidylinositol kinase activity 7/2783 26/18639 0.269230769230769 1.80315929130158 0.0815439876783359 0.303809599807286 GO:0002039 p53 binding 15/2783 69/18639 0.217391304347826 1.4559671296224 0.0823555102788862 0.305089731260419 GO:0008080 N-acetyltransferase activity 15/2783 69/18639 0.217391304347826 1.4559671296224 0.0823555102788862 0.305089731260419 GO:0043178 alcohol binding 19/2783 92/18639 0.206521739130435 1.38316877314128 0.08518662219776 0.314683726192292 GO:0004520 DNA endonuclease activity 10/2783 42/18639 0.238095238095238 1.59463066577691 0.0862148299000332 0.316898824332625 GO:0005246 calcium channel regulator activity 12/2783 53/18639 0.226415094339623 1.51640350104069 0.0879499955418907 0.316898824332625 GO:1901505 carbohydrate derivative transmembrane transporter activity 12/2783 53/18639 0.226415094339623 1.51640350104069 0.0879499955418907 0.316898824332625 GO:0015101 organic cation transmembrane transporter activity 17/2783 81/18639 0.209876543209877 1.40563740168483 0.0883467064611103 0.316898824332625 GO:0008234 cysteine-type peptidase activity 35/2783 187/18639 0.18716577540107 1.25353319716153 0.0901569454194058 0.316898824332625 GO:0008081 phosphoric diester hydrolase activity 18/2783 87/18639 0.206896551724138 1.3856790612958 0.0907189956218889 0.316898824332625 GO:0004000 adenosine deaminase activity 4/2783 12/18639 0.333333333333333 2.23248293208768 0.0908896934819032 0.316898824332625 GO:0004859 phospholipase inhibitor activity 4/2783 12/18639 0.333333333333333 2.23248293208768 0.0908896934819032 0.316898824332625 GO:0004875 complement receptor activity 4/2783 12/18639 0.333333333333333 2.23248293208768 0.0908896934819032 0.316898824332625 GO:0005049 nuclear export signal receptor activity 4/2783 12/18639 0.333333333333333 2.23248293208768 0.0908896934819032 0.316898824332625 GO:0035197 siRNA binding 4/2783 12/18639 0.333333333333333 2.23248293208768 0.0908896934819032 0.316898824332625 GO:0035259 nuclear glucocorticoid receptor binding 4/2783 12/18639 0.333333333333333 2.23248293208768 0.0908896934819032 0.316898824332625 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 4/2783 12/18639 0.333333333333333 2.23248293208768 0.0908896934819032 0.316898824332625 GO:0070008 serine-type exopeptidase activity 4/2783 12/18639 0.333333333333333 2.23248293208768 0.0908896934819032 0.316898824332625 GO:0070410 co-SMAD binding 4/2783 12/18639 0.333333333333333 2.23248293208768 0.0908896934819032 0.316898824332625 GO:0097677 STAT family protein binding 4/2783 12/18639 0.333333333333333 2.23248293208768 0.0908896934819032 0.316898824332625 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 4/2783 12/18639 0.333333333333333 2.23248293208768 0.0908896934819032 0.316898824332625 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 4/2783 12/18639 0.333333333333333 2.23248293208768 0.0908896934819032 0.316898824332625 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 4/2783 12/18639 0.333333333333333 2.23248293208768 0.0908896934819032 0.316898824332625 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 4/2783 12/18639 0.333333333333333 2.23248293208768 0.0908896934819032 0.316898824332625 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 4/2783 12/18639 0.333333333333333 2.23248293208768 0.0908896934819032 0.316898824332625 GO:0051213 dioxygenase activity 19/2783 93/18639 0.204301075268817 1.36829599063438 0.0927489585524471 0.320878766487222 GO:0051219 phosphoprotein binding 19/2783 93/18639 0.204301075268817 1.36829599063438 0.0927489585524471 0.320878766487222 GO:0004879 nuclear receptor activity 13/2783 59/18639 0.220338983050847 1.47570905680372 0.0927693979798181 0.320878766487222 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 5/2783 17/18639 0.294117647058824 1.96983788125383 0.0970851375970948 0.331366889581456 GO:0019198 transmembrane receptor protein phosphatase activity 5/2783 17/18639 0.294117647058824 1.96983788125383 0.0970851375970948 0.331366889581456 GO:0004857 enzyme inhibitor activity 72/2783 416/18639 0.173076923076923 1.15917383012245 0.0974575401431425 0.331366889581456 GO:0004712 protein serine/threonine/tyrosine kinase activity 10/2783 43/18639 0.232558139534884 1.55754623168908 0.098021664458649 0.331366889581456 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 6/2783 22/18639 0.272727272727273 1.82657694443537 0.098088665167517 0.331366889581456 GO:0031683 G-protein beta/gamma-subunit complex binding 6/2783 22/18639 0.272727272727273 1.82657694443537 0.098088665167517 0.331366889581456 GO:0033691 sialic acid binding 6/2783 22/18639 0.272727272727273 1.82657694443537 0.098088665167517 0.331366889581456 GO:0061133 endopeptidase activator activity 6/2783 22/18639 0.272727272727273 1.82657694443537 0.098088665167517 0.331366889581456 GO:0140035 ubiquitin-like protein reader activity 6/2783 22/18639 0.272727272727273 1.82657694443537 0.098088665167517 0.331366889581456 GO:0016651 oxidoreductase activity, acting on NAD(P)H 18/2783 88/18639 0.204545454545455 1.36993270832653 0.0988681690932725 0.33313718991635 GO:0005516 calmodulin binding 38/2783 207/18639 0.183574879227053 1.22948335390336 0.100258165047026 0.336950121704439 GO:0015291 secondary active transmembrane transporter activity 51/2783 287/18639 0.177700348432056 1.19013898470179 0.102726050908285 0.344356736206694 GO:0098531 ligand-modulated transcription factor activity 13/2783 60/18639 0.216666666666667 1.45111390585699 0.103023387319955 0.344467941192875 GO:0061134 peptidase regulator activity 41/2783 226/18639 0.18141592920354 1.21502389666719 0.104289296428103 0.347808804455874 GO:0030296 protein tyrosine kinase activator activity 8/2783 33/18639 0.242424242424242 1.62362395060922 0.108246100981027 0.360083968569537 GO:0008374 O-acyltransferase activity 12/2783 55/18639 0.218181818181818 1.4612615555483 0.109661473750327 0.363864024861136 GO:0001046 core promoter sequence-specific DNA binding 10/2783 44/18639 0.227272727272727 1.52214745369614 0.110727180443273 0.36461677600512 GO:0016790 thiolester hydrolase activity 10/2783 44/18639 0.227272727272727 1.52214745369614 0.110727180443273 0.36461677600512 GO:0019205 nucleobase-containing compound kinase activity 10/2783 44/18639 0.227272727272727 1.52214745369614 0.110727180443273 0.36461677600512 GO:0141052 histone H3 demethylase activity 7/2783 28/18639 0.25 1.67436219906576 0.11294033342252 0.370967745045254 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 13/2783 61/18639 0.213114754098361 1.42732515330196 0.11392987565882 0.37314955978352 GO:0005338 nucleotide-sugar transmembrane transporter activity 4/2783 13/18639 0.307692307692308 2.06075347577324 0.11639433601764 0.37314955978352 GO:0008035 high-density lipoprotein particle binding 4/2783 13/18639 0.307692307692308 2.06075347577324 0.11639433601764 0.37314955978352 GO:0019855 calcium channel inhibitor activity 4/2783 13/18639 0.307692307692308 2.06075347577324 0.11639433601764 0.37314955978352 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 4/2783 13/18639 0.307692307692308 2.06075347577324 0.11639433601764 0.37314955978352 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 4/2783 13/18639 0.307692307692308 2.06075347577324 0.11639433601764 0.37314955978352 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 4/2783 13/18639 0.307692307692308 2.06075347577324 0.11639433601764 0.37314955978352 GO:0004602 glutathione peroxidase activity 6/2783 23/18639 0.260869565217391 1.74716055554688 0.116752316251285 0.37314955978352 GO:0042171 lysophosphatidic acid acyltransferase activity 6/2783 23/18639 0.260869565217391 1.74716055554688 0.116752316251285 0.37314955978352 GO:0071617 lysophospholipid acyltransferase activity 6/2783 23/18639 0.260869565217391 1.74716055554688 0.116752316251285 0.37314955978352 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 6/2783 23/18639 0.260869565217391 1.74716055554688 0.116752316251285 0.37314955978352 GO:0000900 mRNA regulatory element binding translation repressor activity 5/2783 18/18639 0.277777777777778 1.8604024434064 0.118658659112981 0.374651068966895 GO:0015172 acidic amino acid transmembrane transporter activity 5/2783 18/18639 0.277777777777778 1.8604024434064 0.118658659112981 0.374651068966895 GO:0034185 apolipoprotein binding 5/2783 18/18639 0.277777777777778 1.8604024434064 0.118658659112981 0.374651068966895 GO:0050811 GABA receptor binding 5/2783 18/18639 0.277777777777778 1.8604024434064 0.118658659112981 0.374651068966895 GO:0070064 proline-rich region binding 5/2783 18/18639 0.277777777777778 1.8604024434064 0.118658659112981 0.374651068966895 GO:0008009 chemokine activity 10/2783 45/18639 0.222222222222222 1.48832195472512 0.124317890160914 0.391571325530994 GO:0015179 L-amino acid transmembrane transporter activity 13/2783 62/18639 0.209677419354839 1.4043037798616 0.125482925928184 0.394288519061088 GO:0032934 sterol binding 14/2783 68/18639 0.205882352941176 1.37888651687768 0.1286140149563 0.402735274054596 GO:0004620 phospholipase activity 21/2783 109/18639 0.192660550458716 1.2903341717571 0.128788810798134 0.402735274054596 GO:0004629 phospholipase C activity 7/2783 29/18639 0.241379310344828 1.61662557151177 0.130702408969884 0.405799860230305 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 7/2783 29/18639 0.241379310344828 1.61662557151177 0.130702408969884 0.405799860230305 GO:0097472 cyclin-dependent protein kinase activity 7/2783 29/18639 0.241379310344828 1.61662557151177 0.130702408969884 0.405799860230305 GO:0015036 disulfide oxidoreductase activity 9/2783 40/18639 0.225 1.50692597915918 0.132361707483616 0.409975455008635 GO:0015295 solute:proton symporter activity 6/2783 24/18639 0.25 1.67436219906576 0.137042843213945 0.421471385733453 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 6/2783 24/18639 0.25 1.67436219906576 0.137042843213945 0.421471385733453 GO:0050699 WW domain binding 6/2783 24/18639 0.25 1.67436219906576 0.137042843213945 0.421471385733453 GO:0030291 protein serine/threonine kinase inhibitor activity 10/2783 46/18639 0.217391304347826 1.4559671296224 0.138772728982764 0.42578738492594 GO:0005154 epidermal growth factor receptor binding 8/2783 35/18639 0.228571428571429 1.53084543914583 0.140865703796648 0.431194548710867 GO:0043395 heparan sulfate proteoglycan binding 5/2783 19/18639 0.263157894736842 1.76248652533238 0.142258003266554 0.431494165237123 GO:0097001 ceramide binding 5/2783 19/18639 0.263157894736842 1.76248652533238 0.142258003266554 0.431494165237123 GO:1990380 K48-linked deubiquitinase activity 5/2783 19/18639 0.263157894736842 1.76248652533238 0.142258003266554 0.431494165237123 GO:0005080 protein kinase C binding 11/2783 52/18639 0.211538461538462 1.4167680145941 0.143717925720122 0.431494165237123 GO:0005161 platelet-derived growth factor receptor binding 4/2783 14/18639 0.285714285714286 1.91355679893229 0.14460348942379 0.431494165237123 GO:0008191 metalloendopeptidase inhibitor activity 4/2783 14/18639 0.285714285714286 1.91355679893229 0.14460348942379 0.431494165237123 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 4/2783 14/18639 0.285714285714286 1.91355679893229 0.14460348942379 0.431494165237123 GO:0032036 myosin heavy chain binding 4/2783 14/18639 0.285714285714286 1.91355679893229 0.14460348942379 0.431494165237123 GO:0032454 histone H3K9 demethylase activity 4/2783 14/18639 0.285714285714286 1.91355679893229 0.14460348942379 0.431494165237123 GO:0046030 inositol trisphosphate phosphatase activity 4/2783 14/18639 0.285714285714286 1.91355679893229 0.14460348942379 0.431494165237123 GO:0070742 C2H2 zinc finger domain binding 4/2783 14/18639 0.285714285714286 1.91355679893229 0.14460348942379 0.431494165237123 GO:0004536 DNA nuclease activity 13/2783 64/18639 0.203125 1.36041928674093 0.150485059028097 0.44801944514301 GO:0140034 methylation-dependent protein binding 15/2783 76/18639 0.197368421052632 1.32186489399928 0.154422539564895 0.458694741668844 GO:0015078 proton transmembrane transporter activity 33/2783 185/18639 0.178378378378378 1.19468005554962 0.155868848121491 0.461335621593679 GO:0016798 hydrolase activity, acting on glycosyl bonds 24/2783 130/18639 0.184615384615385 1.23645208546394 0.156093679601948 0.461335621593679 GO:0051018 protein kinase A binding 11/2783 53/18639 0.207547169811321 1.39003654262063 0.158323812195373 0.461335621593679 GO:0003707 nuclear steroid receptor activity 6/2783 25/18639 0.24 1.60738771110313 0.158849458662241 0.461335621593679 GO:0015645 fatty acid ligase activity 6/2783 25/18639 0.24 1.60738771110313 0.158849458662241 0.461335621593679 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 6/2783 25/18639 0.24 1.60738771110313 0.158849458662241 0.461335621593679 GO:0019211 phosphatase activator activity 6/2783 25/18639 0.24 1.60738771110313 0.158849458662241 0.461335621593679 GO:0019706 protein-cysteine S-palmitoyltransferase activity 6/2783 25/18639 0.24 1.60738771110313 0.158849458662241 0.461335621593679 GO:0019707 protein-cysteine S-acyltransferase activity 6/2783 25/18639 0.24 1.60738771110313 0.158849458662241 0.461335621593679 GO:0120515 fatty acid-CoA ligase activity 6/2783 25/18639 0.24 1.60738771110313 0.158849458662241 0.461335621593679 GO:0048487 beta-tubulin binding 9/2783 42/18639 0.214285714285714 1.43516759919922 0.165368291430884 0.479200560057495 GO:0016505 peptidase activator activity involved in apoptotic process 5/2783 20/18639 0.25 1.67436219906576 0.167690711435322 0.481649091875903 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 5/2783 20/18639 0.25 1.67436219906576 0.167690711435322 0.481649091875903 GO:0052745 inositol phosphate phosphatase activity 5/2783 20/18639 0.25 1.67436219906576 0.167690711435322 0.481649091875903 GO:0061608 nuclear import signal receptor activity 5/2783 20/18639 0.25 1.67436219906576 0.167690711435322 0.481649091875903 GO:0016411 acylglycerol O-acyltransferase activity 7/2783 31/18639 0.225806451612903 1.51232714754326 0.170022920422008 0.486205895241883 GO:0047499 calcium-independent phospholipase A2 activity 7/2783 31/18639 0.225806451612903 1.51232714754326 0.170022920422008 0.486205895241883 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 11/2783 54/18639 0.203703703703704 1.36429512516469 0.173641426731621 0.486528470914557 GO:0015929 hexosaminidase activity 4/2783 15/18639 0.266666666666667 1.78598634567014 0.175149097371241 0.486528470914557 GO:0050780 dopamine receptor binding 4/2783 15/18639 0.266666666666667 1.78598634567014 0.175149097371241 0.486528470914557 GO:0001098 basal transcription machinery binding 12/2783 60/18639 0.2 1.33948975925261 0.176149207185627 0.486528470914557 GO:0001099 basal RNA polymerase II transcription machinery binding 12/2783 60/18639 0.2 1.33948975925261 0.176149207185627 0.486528470914557 GO:0001094 TFIID-class transcription factor complex binding 3/2783 10/18639 0.3 2.00923463887891 0.177970920725647 0.486528470914557 GO:0004090 carbonyl reductase (NADPH) activity 3/2783 10/18639 0.3 2.00923463887891 0.177970920725647 0.486528470914557 GO:0004445 inositol-polyphosphate 5-phosphatase activity 3/2783 10/18639 0.3 2.00923463887891 0.177970920725647 0.486528470914557 GO:0005345 purine nucleobase transmembrane transporter activity 3/2783 10/18639 0.3 2.00923463887891 0.177970920725647 0.486528470914557 GO:0015924 mannosyl-oligosaccharide mannosidase activity 3/2783 10/18639 0.3 2.00923463887891 0.177970920725647 0.486528470914557 GO:0016175 superoxide-generating NAD(P)H oxidase activity 3/2783 10/18639 0.3 2.00923463887891 0.177970920725647 0.486528470914557 GO:0016303 1-phosphatidylinositol-3-kinase activity 3/2783 10/18639 0.3 2.00923463887891 0.177970920725647 0.486528470914557 GO:0016783 sulfurtransferase activity 3/2783 10/18639 0.3 2.00923463887891 0.177970920725647 0.486528470914557 GO:0031419 cobalamin binding 3/2783 10/18639 0.3 2.00923463887891 0.177970920725647 0.486528470914557 GO:0031957 very long-chain fatty acid-CoA ligase activity 3/2783 10/18639 0.3 2.00923463887891 0.177970920725647 0.486528470914557 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 3/2783 10/18639 0.3 2.00923463887891 0.177970920725647 0.486528470914557 GO:0043208 glycosphingolipid binding 3/2783 10/18639 0.3 2.00923463887891 0.177970920725647 0.486528470914557 GO:0043422 protein kinase B binding 3/2783 10/18639 0.3 2.00923463887891 0.177970920725647 0.486528470914557 GO:0051864 histone H3K36 demethylase activity 3/2783 10/18639 0.3 2.00923463887891 0.177970920725647 0.486528470914557 GO:0070097 delta-catenin binding 3/2783 10/18639 0.3 2.00923463887891 0.177970920725647 0.486528470914557 GO:0070513 death domain binding 3/2783 10/18639 0.3 2.00923463887891 0.177970920725647 0.486528470914557 GO:0042379 chemokine receptor binding 14/2783 72/18639 0.194444444444444 1.30228171038448 0.179069903036499 0.48850868945522 GO:0051117 ATPase binding 16/2783 84/18639 0.19047619047619 1.27570453262153 0.180090381926659 0.49026692699867 GO:0004435 phosphatidylinositol phospholipase C activity 6/2783 26/18639 0.230769230769231 1.54556510682993 0.182041099957412 0.492492934324616 GO:0030247 polysaccharide binding 6/2783 26/18639 0.230769230769231 1.54556510682993 0.182041099957412 0.492492934324616 GO:0097602 cullin family protein binding 6/2783 26/18639 0.230769230769231 1.54556510682993 0.182041099957412 0.492492934324616 GO:0060590 ATPase regulator activity 10/2783 49/18639 0.204081632653061 1.36682628495164 0.187005524202131 0.504876197845918 GO:0043425 bHLH transcription factor binding 7/2783 32/18639 0.21875 1.46506692418254 0.191403333915466 0.515088779904405 GO:0043539 protein serine/threonine kinase activator activity 14/2783 73/18639 0.191780821917808 1.28444223489976 0.193021313232683 0.515088779904405 GO:0033293 monocarboxylic acid binding 15/2783 79/18639 0.189873417721519 1.27166749296133 0.193167031515623 0.515088779904405 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 5/2783 21/18639 0.238095238095238 1.59463066577691 0.194738319396374 0.515088779904405 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 5/2783 21/18639 0.238095238095238 1.59463066577691 0.194738319396374 0.515088779904405 GO:0010314 phosphatidylinositol-5-phosphate binding 5/2783 21/18639 0.238095238095238 1.59463066577691 0.194738319396374 0.515088779904405 GO:0035613 RNA stem-loop binding 5/2783 21/18639 0.238095238095238 1.59463066577691 0.194738319396374 0.515088779904405 GO:0061891 calcium ion sensor activity 5/2783 21/18639 0.238095238095238 1.59463066577691 0.194738319396374 0.515088779904405 GO:0072542 protein phosphatase activator activity 5/2783 21/18639 0.238095238095238 1.59463066577691 0.194738319396374 0.515088779904405 GO:0140312 cargo adaptor activity 5/2783 21/18639 0.238095238095238 1.59463066577691 0.194738319396374 0.515088779904405 GO:0051087 protein-folding chaperone binding 24/2783 134/18639 0.17910447761194 1.19954306798741 0.19548592597903 0.51601952930497 GO:0031490 chromatin DNA binding 23/2783 128/18639 0.1796875 1.20344783057851 0.197113223333983 0.519263925712149 GO:0003774 cytoskeletal motor activity 27/2783 153/18639 0.176470588235294 1.1819027287523 0.200165003774058 0.526240251857604 GO:0015297 antiporter activity 24/2783 135/18639 0.177777777777778 1.19065756378009 0.206053636182284 0.531933977162574 GO:0001671 ATPase activator activity 6/2783 27/18639 0.222222222222222 1.48832195472512 0.206470604221735 0.531933977162574 GO:0004364 glutathione transferase activity 6/2783 27/18639 0.222222222222222 1.48832195472512 0.206470604221735 0.531933977162574 GO:0016405 CoA-ligase activity 6/2783 27/18639 0.222222222222222 1.48832195472512 0.206470604221735 0.531933977162574 GO:0035064 methylated histone binding 14/2783 74/18639 0.189189189189189 1.26708490740111 0.207463933399875 0.531933977162574 GO:0000062 fatty-acyl-CoA binding 4/2783 16/18639 0.25 1.67436219906576 0.207633738018213 0.531933977162574 GO:0004707 MAP kinase activity 4/2783 16/18639 0.25 1.67436219906576 0.207633738018213 0.531933977162574 GO:0004708 MAP kinase kinase activity 4/2783 16/18639 0.25 1.67436219906576 0.207633738018213 0.531933977162574 GO:0005024 transforming growth factor beta receptor activity 4/2783 16/18639 0.25 1.67436219906576 0.207633738018213 0.531933977162574 GO:0015923 mannosidase activity 4/2783 16/18639 0.25 1.67436219906576 0.207633738018213 0.531933977162574 GO:0016722 oxidoreductase activity, acting on metal ions 4/2783 16/18639 0.25 1.67436219906576 0.207633738018213 0.531933977162574 GO:0031435 mitogen-activated protein kinase kinase kinase binding 4/2783 16/18639 0.25 1.67436219906576 0.207633738018213 0.531933977162574 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 4/2783 16/18639 0.25 1.67436219906576 0.207633738018213 0.531933977162574 GO:0001851 complement component C3b binding 3/2783 11/18639 0.272727272727273 1.82657694443537 0.219057402972864 0.552516157595 GO:0003953 NAD+ nucleosidase activity 3/2783 11/18639 0.272727272727273 1.82657694443537 0.219057402972864 0.552516157595 GO:0004143 ATP-dependent diacylglycerol kinase activity 3/2783 11/18639 0.272727272727273 1.82657694443537 0.219057402972864 0.552516157595 GO:0008199 ferric iron binding 3/2783 11/18639 0.272727272727273 1.82657694443537 0.219057402972864 0.552516157595 GO:0015205 nucleobase transmembrane transporter activity 3/2783 11/18639 0.272727272727273 1.82657694443537 0.219057402972864 0.552516157595 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 3/2783 11/18639 0.272727272727273 1.82657694443537 0.219057402972864 0.552516157595 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 3/2783 11/18639 0.272727272727273 1.82657694443537 0.219057402972864 0.552516157595 GO:0070697 activin receptor binding 3/2783 11/18639 0.272727272727273 1.82657694443537 0.219057402972864 0.552516157595 GO:0030971 receptor tyrosine kinase binding 15/2783 81/18639 0.185185185185185 1.24026829560426 0.221313804528796 0.557129731863996 GO:0050321 tau-protein kinase activity 5/2783 22/18639 0.227272727272727 1.52214745369614 0.223164688287214 0.559628372166399 GO:0140784 metal ion sensor activity 5/2783 22/18639 0.227272727272727 1.52214745369614 0.223164688287214 0.559628372166399 GO:0022853 active monoatomic ion transmembrane transporter activity 21/2783 118/18639 0.177966101694915 1.19191885357223 0.223614039387997 0.559678900886657 GO:0046625 sphingolipid binding 6/2783 28/18639 0.214285714285714 1.43516759919922 0.231978859894248 0.5777997127148 GO:0051959 dynein light intermediate chain binding 6/2783 28/18639 0.214285714285714 1.43516759919922 0.231978859894248 0.5777997127148 GO:0016410 N-acyltransferase activity 17/2783 94/18639 0.180851063829787 1.2112407397497 0.232183320139996 0.5777997127148 GO:0046943 carboxylic acid transmembrane transporter activity 32/2783 188/18639 0.170212765957447 1.1399912844703 0.236606402528796 0.587685235995333 GO:0015035 protein-disulfide reductase activity 7/2783 34/18639 0.205882352941176 1.37888651687768 0.237072882150237 0.587724407459904 GO:0004177 aminopeptidase activity 8/2783 40/18639 0.2 1.33948975925261 0.239901647629213 0.587891593955411 GO:0004180 carboxypeptidase activity 9/2783 46/18639 0.195652173913043 1.31037041666016 0.241259871244278 0.587891593955411 GO:0030276 clathrin binding 9/2783 46/18639 0.195652173913043 1.31037041666016 0.241259871244278 0.587891593955411 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 11/2783 58/18639 0.189655172413793 1.27020580618781 0.241276203054255 0.587891593955411 GO:0004659 prenyltransferase activity 4/2783 17/18639 0.235294117647059 1.57587030500306 0.241648691993942 0.587891593955411 GO:0008484 sulfuric ester hydrolase activity 4/2783 17/18639 0.235294117647059 1.57587030500306 0.241648691993942 0.587891593955411 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 4/2783 17/18639 0.235294117647059 1.57587030500306 0.241648691993942 0.587891593955411 GO:0032977 membrane insertase activity 4/2783 17/18639 0.235294117647059 1.57587030500306 0.241648691993942 0.587891593955411 GO:1901567 fatty acid derivative binding 4/2783 17/18639 0.235294117647059 1.57587030500306 0.241648691993942 0.587891593955411 GO:1990226 histone methyltransferase binding 4/2783 17/18639 0.235294117647059 1.57587030500306 0.241648691993942 0.587891593955411 GO:0141108 transporter regulator activity 29/2783 170/18639 0.170588235294118 1.14250597112722 0.245906239398604 0.597135449116907 GO:0005342 organic acid transmembrane transporter activity 32/2783 189/18639 0.169312169312169 1.13395958455247 0.246434182982659 0.59730515726652 GO:0031681 G-protein beta-subunit binding 5/2783 23/18639 0.217391304347826 1.4559671296224 0.252723680519417 0.608792897932165 GO:0043274 phospholipase binding 5/2783 23/18639 0.217391304347826 1.4559671296224 0.252723680519417 0.608792897932165 GO:0004519 endonuclease activity 22/2783 127/18639 0.173228346456693 1.16018798045501 0.257484936581632 0.608792897932165 GO:0016417 S-acyltransferase activity 6/2783 29/18639 0.206896551724138 1.3856790612958 0.258398803613647 0.608792897932165 GO:0070063 RNA polymerase binding 11/2783 59/18639 0.186440677966102 1.24867689421853 0.259552739684658 0.608792897932165 GO:0004864 protein phosphatase inhibitor activity 10/2783 53/18639 0.188679245283019 1.26366958420057 0.260989944099699 0.608792897932165 GO:0004623 phospholipase A2 activity 7/2783 35/18639 0.2 1.33948975925261 0.261124676738635 0.608792897932165 GO:0043015 gamma-tubulin binding 7/2783 35/18639 0.2 1.33948975925261 0.261124676738635 0.608792897932165 GO:0140566 histone reader activity 7/2783 35/18639 0.2 1.33948975925261 0.261124676738635 0.608792897932165 GO:0003995 acyl-CoA dehydrogenase activity 3/2783 12/18639 0.25 1.67436219906576 0.261779972803185 0.608792897932165 GO:0004126 cytidine deaminase activity 3/2783 12/18639 0.25 1.67436219906576 0.261779972803185 0.608792897932165 GO:0005078 MAP-kinase scaffold activity 3/2783 12/18639 0.25 1.67436219906576 0.261779972803185 0.608792897932165 GO:0005247 voltage-gated chloride channel activity 3/2783 12/18639 0.25 1.67436219906576 0.261779972803185 0.608792897932165 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 3/2783 12/18639 0.25 1.67436219906576 0.261779972803185 0.608792897932165 GO:0008504 monoamine transmembrane transporter activity 3/2783 12/18639 0.25 1.67436219906576 0.261779972803185 0.608792897932165 GO:0008603 cAMP-dependent protein kinase regulator activity 3/2783 12/18639 0.25 1.67436219906576 0.261779972803185 0.608792897932165 GO:0015368 calcium:monoatomic cation antiporter activity 3/2783 12/18639 0.25 1.67436219906576 0.261779972803185 0.608792897932165 GO:0016208 AMP binding 3/2783 12/18639 0.25 1.67436219906576 0.261779972803185 0.608792897932165 GO:0016840 carbon-nitrogen lyase activity 3/2783 12/18639 0.25 1.67436219906576 0.261779972803185 0.608792897932165 GO:0043047 single-stranded telomeric DNA binding 3/2783 12/18639 0.25 1.67436219906576 0.261779972803185 0.608792897932165 GO:0045295 gamma-catenin binding 3/2783 12/18639 0.25 1.67436219906576 0.261779972803185 0.608792897932165 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 3/2783 12/18639 0.25 1.67436219906576 0.261779972803185 0.608792897932165 GO:0140938 histone H3 methyltransferase activity 9/2783 47/18639 0.191489361702128 1.28249019502909 0.261911668512227 0.608792897932165 GO:0019199 transmembrane receptor protein kinase activity 14/2783 78/18639 0.179487179487179 1.20210619420106 0.269583621173453 0.625510750907799 GO:0015399 primary active transmembrane transporter activity 28/2783 166/18639 0.168674698795181 1.12969015840581 0.270951119535541 0.627567069048571 GO:0008235 metalloexopeptidase activity 12/2783 66/18639 0.181818181818182 1.21771796295691 0.275498984928812 0.635444483469379 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 4/2783 18/18639 0.222222222222222 1.48832195472512 0.276788701388503 0.635444483469379 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 4/2783 18/18639 0.222222222222222 1.48832195472512 0.276788701388503 0.635444483469379 GO:0031690 adrenergic receptor binding 4/2783 18/18639 0.222222222222222 1.48832195472512 0.276788701388503 0.635444483469379 GO:0035615 clathrin adaptor activity 4/2783 18/18639 0.222222222222222 1.48832195472512 0.276788701388503 0.635444483469379 GO:0009055 electron transfer activity 20/2783 116/18639 0.172413793103448 1.15473255107983 0.277626545657624 0.636247830470195 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 11/2783 60/18639 0.183333333333333 1.22786561264822 0.278275981674236 0.636617333514392 GO:0003925 G protein activity 10/2783 54/18639 0.185185185185185 1.24026829560426 0.280841879865171 0.641362191495943 GO:0004622 lysophospholipase activity 5/2783 24/18639 0.208333333333333 1.3953018325548 0.28316600612612 0.643290020885819 GO:0030215 semaphorin receptor binding 5/2783 24/18639 0.208333333333333 1.3953018325548 0.28316600612612 0.643290020885819 GO:0070840 dynein complex binding 5/2783 24/18639 0.208333333333333 1.3953018325548 0.28316600612612 0.643290020885819 GO:0004190 aspartic-type endopeptidase activity 7/2783 36/18639 0.194444444444444 1.30228171038448 0.285821281039676 0.64706762235371 GO:0045505 dynein intermediate chain binding 7/2783 36/18639 0.194444444444444 1.30228171038448 0.285821281039676 0.64706762235371 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 3/2783 13/18639 0.230769230769231 1.54556510682993 0.305395663838848 0.683080524263908 GO:0005172 vascular endothelial growth factor receptor binding 3/2783 13/18639 0.230769230769231 1.54556510682993 0.305395663838848 0.683080524263908 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 3/2783 13/18639 0.230769230769231 1.54556510682993 0.305395663838848 0.683080524263908 GO:0046974 histone H3K9 methyltransferase activity 3/2783 13/18639 0.230769230769231 1.54556510682993 0.305395663838848 0.683080524263908 GO:0070123 transforming growth factor beta receptor activity, type III 3/2783 13/18639 0.230769230769231 1.54556510682993 0.305395663838848 0.683080524263908 GO:0071714 icosanoid transmembrane transporter activity 3/2783 13/18639 0.230769230769231 1.54556510682993 0.305395663838848 0.683080524263908 GO:0089720 caspase binding 3/2783 13/18639 0.230769230769231 1.54556510682993 0.305395663838848 0.683080524263908 GO:0048029 monosaccharide binding 13/2783 74/18639 0.175675675675676 1.17657884258675 0.307375376164338 0.686331319380646 GO:0008375 acetylglucosaminyltransferase activity 8/2783 43/18639 0.186046511627907 1.24603698535126 0.308071128820111 0.686708977746024 GO:0042805 actinin binding 7/2783 37/18639 0.189189189189189 1.26708490740111 0.311034837322376 0.687543064533028 GO:0070001 aspartic-type peptidase activity 7/2783 37/18639 0.189189189189189 1.26708490740111 0.311034837322376 0.687543064533028 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 12/2783 68/18639 0.176470588235294 1.1819027287523 0.312056691510183 0.687543064533028 GO:0005125 cytokine activity 38/2783 234/18639 0.162393162393162 1.08761988999143 0.312428878067919 0.687543064533028 GO:0120227 acyl-CoA binding 4/2783 19/18639 0.210526315789474 1.4099892202659 0.312663554221022 0.687543064533028 GO:0016878 acid-thiol ligase activity 6/2783 31/18639 0.193548387096774 1.29628041217994 0.31328785894785 0.687543064533028 GO:0001848 complement binding 5/2783 25/18639 0.2 1.33948975925261 0.31424514299209 0.687543064533028 GO:0008139 nuclear localization sequence binding 5/2783 25/18639 0.2 1.33948975925261 0.31424514299209 0.687543064533028 GO:0017025 TBP-class protein binding 5/2783 25/18639 0.2 1.33948975925261 0.31424514299209 0.687543064533028 GO:0042974 nuclear retinoic acid receptor binding 5/2783 25/18639 0.2 1.33948975925261 0.31424514299209 0.687543064533028 GO:0120020 cholesterol transfer activity 5/2783 25/18639 0.2 1.33948975925261 0.31424514299209 0.687543064533028 GO:0019212 phosphatase inhibitor activity 10/2783 56/18639 0.178571428571429 1.19597299933268 0.321727134863585 0.701558835889824 GO:0030170 pyridoxal phosphate binding 10/2783 56/18639 0.178571428571429 1.19597299933268 0.321727134863585 0.701558835889824 GO:0015605 organophosphate ester transmembrane transporter activity 9/2783 50/18639 0.18 1.20554078332734 0.326685578219976 0.7111819599313 GO:0061135 endopeptidase regulator activity 30/2783 184/18639 0.16304347826087 1.0919753472168 0.329694806801588 0.716536713448784 GO:0003954 NADH dehydrogenase activity 8/2783 44/18639 0.181818181818182 1.21771796295691 0.331680266495174 0.719652358585204 GO:0140104 molecular carrier activity 40/2783 249/18639 0.160642570281124 1.07589538895792 0.332754719090204 0.720784308461172 GO:0042887 amide transmembrane transporter activity 7/2783 38/18639 0.184210526315789 1.23374056773266 0.336637530830898 0.726780364575316 GO:0043531 ADP binding 7/2783 38/18639 0.184210526315789 1.23374056773266 0.336637530830898 0.726780364575316 GO:0047498 calcium-dependent phospholipase A2 activity 6/2783 32/18639 0.1875 1.25577164929932 0.341415057032246 0.729838926051302 GO:0051059 NF-kappaB binding 6/2783 32/18639 0.1875 1.25577164929932 0.341415057032246 0.729838926051302 GO:0070279 vitamin B6 binding 10/2783 57/18639 0.175438596491228 1.17499101688825 0.342626811148422 0.729838926051302 GO:0005496 steroid binding 18/2783 108/18639 0.166666666666667 1.11624146604384 0.344987548608404 0.729838926051302 GO:0034237 protein kinase A regulatory subunit binding 5/2783 26/18639 0.192307692307692 1.28797092235827 0.345722296095584 0.729838926051302 GO:0051139 metal cation:proton antiporter activity 5/2783 26/18639 0.192307692307692 1.28797092235827 0.345722296095584 0.729838926051302 GO:0070006 metalloaminopeptidase activity 5/2783 26/18639 0.192307692307692 1.28797092235827 0.345722296095584 0.729838926051302 GO:0015095 magnesium ion transmembrane transporter activity 4/2783 20/18639 0.2 1.33948975925261 0.348906764917447 0.729838926051302 GO:0031418 L-ascorbic acid binding 4/2783 20/18639 0.2 1.33948975925261 0.348906764917447 0.729838926051302 GO:0042288 MHC class I protein binding 4/2783 20/18639 0.2 1.33948975925261 0.348906764917447 0.729838926051302 GO:0043024 ribosomal small subunit binding 4/2783 20/18639 0.2 1.33948975925261 0.348906764917447 0.729838926051302 GO:0016830 carbon-carbon lyase activity 9/2783 51/18639 0.176470588235294 1.1819027287523 0.348948519810516 0.729838926051302 GO:0004705 JUN kinase activity 3/2783 14/18639 0.214285714285714 1.43516759919922 0.349248075042954 0.729838926051302 GO:0008474 palmitoyl-(protein) hydrolase activity 3/2783 14/18639 0.214285714285714 1.43516759919922 0.349248075042954 0.729838926051302 GO:0008494 translation activator activity 3/2783 14/18639 0.214285714285714 1.43516759919922 0.349248075042954 0.729838926051302 GO:0034236 protein kinase A catalytic subunit binding 3/2783 14/18639 0.214285714285714 1.43516759919922 0.349248075042954 0.729838926051302 GO:0043176 amine binding 3/2783 14/18639 0.214285714285714 1.43516759919922 0.349248075042954 0.729838926051302 GO:0071933 Arp2/3 complex binding 3/2783 14/18639 0.214285714285714 1.43516759919922 0.349248075042954 0.729838926051302 GO:0098599 palmitoyl hydrolase activity 3/2783 14/18639 0.214285714285714 1.43516759919922 0.349248075042954 0.729838926051302 GO:0098847 sequence-specific single stranded DNA binding 3/2783 14/18639 0.214285714285714 1.43516759919922 0.349248075042954 0.729838926051302 GO:0099106 ion channel regulator activity 26/2783 160/18639 0.1625 1.08833542939274 0.351651910419921 0.733686545900124 GO:0016247 channel regulator activity 27/2783 168/18639 0.160714285714286 1.07637569939941 0.370577194973774 0.771937160137063 GO:0035255 ionotropic glutamate receptor binding 5/2783 27/18639 0.185185185185185 1.24026829560426 0.377370407885095 0.784834149732318 GO:0001846 opsonin binding 4/2783 21/18639 0.19047619047619 1.27570453262153 0.385181693275346 0.790394686075604 GO:0008373 sialyltransferase activity 4/2783 21/18639 0.19047619047619 1.27570453262153 0.385181693275346 0.790394686075604 GO:0009931 calcium-dependent protein serine/threonine kinase activity 4/2783 21/18639 0.19047619047619 1.27570453262153 0.385181693275346 0.790394686075604 GO:0015144 carbohydrate transmembrane transporter activity 7/2783 40/18639 0.175 1.17205353934603 0.388509805245484 0.790394686075604 GO:0030331 nuclear estrogen receptor binding 7/2783 40/18639 0.175 1.17205353934603 0.388509805245484 0.790394686075604 GO:0019842 vitamin binding 24/2783 150/18639 0.16 1.07159180740208 0.390338093372228 0.790394686075604 GO:0042626 ATPase-coupled transmembrane transporter activity 16/2783 98/18639 0.163265306122449 1.09346102796131 0.390781032635577 0.790394686075604 GO:0004518 nuclease activity 33/2783 209/18639 0.157894736842105 1.05749191519943 0.392288199819237 0.790394686075604 GO:0004559 alpha-mannosidase activity 3/2783 15/18639 0.2 1.33948975925261 0.392772819460883 0.790394686075604 GO:0004865 protein serine/threonine phosphatase inhibitor activity 3/2783 15/18639 0.2 1.33948975925261 0.392772819460883 0.790394686075604 GO:0005402 carbohydrate:monoatomic cation symporter activity 3/2783 15/18639 0.2 1.33948975925261 0.392772819460883 0.790394686075604 GO:0015556 C4-dicarboxylate transmembrane transporter activity 3/2783 15/18639 0.2 1.33948975925261 0.392772819460883 0.790394686075604 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 3/2783 15/18639 0.2 1.33948975925261 0.392772819460883 0.790394686075604 GO:0030553 cGMP binding 3/2783 15/18639 0.2 1.33948975925261 0.392772819460883 0.790394686075604 GO:0031386 protein tag activity 3/2783 15/18639 0.2 1.33948975925261 0.392772819460883 0.790394686075604 GO:0033130 acetylcholine receptor binding 3/2783 15/18639 0.2 1.33948975925261 0.392772819460883 0.790394686075604 GO:0042809 nuclear vitamin D receptor binding 3/2783 15/18639 0.2 1.33948975925261 0.392772819460883 0.790394686075604 GO:0048531 beta-1,3-galactosyltransferase activity 3/2783 15/18639 0.2 1.33948975925261 0.392772819460883 0.790394686075604 GO:0050700 CARD domain binding 3/2783 15/18639 0.2 1.33948975925261 0.392772819460883 0.790394686075604 GO:0051371 muscle alpha-actinin binding 3/2783 15/18639 0.2 1.33948975925261 0.392772819460883 0.790394686075604 GO:0141047 molecular tag activity 3/2783 15/18639 0.2 1.33948975925261 0.392772819460883 0.790394686075604 GO:0031072 heat shock protein binding 21/2783 131/18639 0.16030534351145 1.07363682993529 0.398181668763387 0.796424221856924 GO:0008376 acetylgalactosaminyltransferase activity 6/2783 34/18639 0.176470588235294 1.1819027287523 0.398212110928462 0.796424221856924 GO:0016831 carboxy-lyase activity 6/2783 34/18639 0.176470588235294 1.1819027287523 0.398212110928462 0.796424221856924 GO:0030332 cyclin binding 6/2783 34/18639 0.176470588235294 1.1819027287523 0.398212110928462 0.796424221856924 GO:0004714 transmembrane receptor protein tyrosine kinase activity 10/2783 60/18639 0.166666666666667 1.11624146604384 0.406350249021915 0.811065754450951 GO:0000287 magnesium ion binding 36/2783 230/18639 0.156521739130435 1.04829633332813 0.406776843106535 0.811065754450951 GO:0046875 ephrin receptor binding 5/2783 28/18639 0.178571428571429 1.19597299933268 0.408977266143974 0.814208175651516 GO:0046982 protein heterodimerization activity 57/2783 369/18639 0.154471544715447 1.03456526121136 0.411769803285388 0.816554195461475 GO:0008137 NADH dehydrogenase (ubiquinone) activity 7/2783 41/18639 0.170731707317073 1.14346686765466 0.414539016407589 0.816554195461475 GO:0015175 neutral L-amino acid transmembrane transporter activity 7/2783 41/18639 0.170731707317073 1.14346686765466 0.414539016407589 0.816554195461475 GO:0017080 sodium channel regulator activity 7/2783 41/18639 0.170731707317073 1.14346686765466 0.414539016407589 0.816554195461475 GO:0042287 MHC protein binding 7/2783 41/18639 0.170731707317073 1.14346686765466 0.414539016407589 0.816554195461475 GO:0140318 protein transporter activity 7/2783 41/18639 0.170731707317073 1.14346686765466 0.414539016407589 0.816554195461475 GO:0140828 metal cation:monoatomic cation antiporter activity 7/2783 41/18639 0.170731707317073 1.14346686765466 0.414539016407589 0.816554195461475 GO:0140463 chromatin-protein adaptor activity 9/2783 54/18639 0.166666666666667 1.11624146604384 0.416630838044111 0.819258865574395 GO:0050840 extracellular matrix binding 11/2783 67/18639 0.164179104477612 1.09958114565512 0.417168624801686 0.819258865574395 GO:0008970 phospholipase A1 activity 4/2783 22/18639 0.181818181818182 1.21771796295691 0.421185472161597 0.823427070013077 GO:0015377 chloride:monoatomic cation symporter activity 4/2783 22/18639 0.181818181818182 1.21771796295691 0.421185472161597 0.823427070013077 GO:0016881 acid-amino acid ligase activity 4/2783 22/18639 0.181818181818182 1.21771796295691 0.421185472161597 0.823427070013077 GO:0015293 symporter activity 23/2783 146/18639 0.157534246575342 1.05507755009623 0.42488418972986 0.829414645819966 GO:0003684 damaged DNA binding 12/2783 74/18639 0.162162162162162 1.08607277777238 0.42678793306147 0.831885597477066 GO:0032266 phosphatidylinositol-3-phosphate binding 8/2783 48/18639 0.166666666666667 1.11624146604384 0.427916470035704 0.832840413323222 GO:0015378 sodium:chloride symporter activity 3/2783 16/18639 0.1875 1.25577164929932 0.43549722287073 0.833522111634584 GO:0015562 efflux transmembrane transporter activity 3/2783 16/18639 0.1875 1.25577164929932 0.43549722287073 0.833522111634584 GO:0016675 oxidoreductase activity, acting on a heme group of donors 3/2783 16/18639 0.1875 1.25577164929932 0.43549722287073 0.833522111634584 GO:0030275 LRR domain binding 3/2783 16/18639 0.1875 1.25577164929932 0.43549722287073 0.833522111634584 GO:0034450 ubiquitin-ubiquitin ligase activity 3/2783 16/18639 0.1875 1.25577164929932 0.43549722287073 0.833522111634584 GO:0030145 manganese ion binding 11/2783 68/18639 0.161764705882353 1.08341083468961 0.437453383857941 0.833522111634584 GO:0003785 actin monomer binding 5/2783 29/18639 0.172413793103448 1.15473255107983 0.440347779171126 0.833522111634584 GO:0035250 UDP-galactosyltransferase activity 5/2783 29/18639 0.172413793103448 1.15473255107983 0.440347779171126 0.833522111634584 GO:0042056 chemoattractant activity 7/2783 42/18639 0.166666666666667 1.11624146604384 0.440479134913849 0.833522111634584 GO:0043175 RNA polymerase core enzyme binding 7/2783 42/18639 0.166666666666667 1.11624146604384 0.440479134913849 0.833522111634584 GO:0016829 lyase activity 31/2783 200/18639 0.155 1.03810456342077 0.440509463225645 0.833522111634584 GO:0035254 glutamate receptor binding 8/2783 49/18639 0.163265306122449 1.09346102796131 0.451957826807475 0.833522111634584 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 2/2783 10/18639 0.2 1.33948975925261 0.453195687997638 0.833522111634584 GO:0004382 GDP phosphatase activity 2/2783 10/18639 0.2 1.33948975925261 0.453195687997638 0.833522111634584 GO:0004862 cAMP-dependent protein kinase inhibitor activity 2/2783 10/18639 0.2 1.33948975925261 0.453195687997638 0.833522111634584 GO:0004955 prostaglandin receptor activity 2/2783 10/18639 0.2 1.33948975925261 0.453195687997638 0.833522111634584 GO:0005522 profilin binding 2/2783 10/18639 0.2 1.33948975925261 0.453195687997638 0.833522111634584 GO:0008190 eukaryotic initiation factor 4E binding 2/2783 10/18639 0.2 1.33948975925261 0.453195687997638 0.833522111634584 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 2/2783 10/18639 0.2 1.33948975925261 0.453195687997638 0.833522111634584 GO:0015187 glycine transmembrane transporter activity 2/2783 10/18639 0.2 1.33948975925261 0.453195687997638 0.833522111634584 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 2/2783 10/18639 0.2 1.33948975925261 0.453195687997638 0.833522111634584 GO:0016868 intramolecular phosphotransferase activity 2/2783 10/18639 0.2 1.33948975925261 0.453195687997638 0.833522111634584 GO:0016889 DNA endonuclease activity, producing 3'-phosphomonoesters 2/2783 10/18639 0.2 1.33948975925261 0.453195687997638 0.833522111634584 GO:0030957 Tat protein binding 2/2783 10/18639 0.2 1.33948975925261 0.453195687997638 0.833522111634584 GO:0031434 mitogen-activated protein kinase kinase binding 2/2783 10/18639 0.2 1.33948975925261 0.453195687997638 0.833522111634584 GO:0031996 thioesterase binding 2/2783 10/18639 0.2 1.33948975925261 0.453195687997638 0.833522111634584 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 2/2783 10/18639 0.2 1.33948975925261 0.453195687997638 0.833522111634584 GO:0035256 G protein-coupled glutamate receptor binding 2/2783 10/18639 0.2 1.33948975925261 0.453195687997638 0.833522111634584 GO:0043121 neurotrophin binding 2/2783 10/18639 0.2 1.33948975925261 0.453195687997638 0.833522111634584 GO:0050308 sugar-phosphatase activity 2/2783 10/18639 0.2 1.33948975925261 0.453195687997638 0.833522111634584 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 2/2783 10/18639 0.2 1.33948975925261 0.453195687997638 0.833522111634584 GO:0050815 phosphoserine residue binding 2/2783 10/18639 0.2 1.33948975925261 0.453195687997638 0.833522111634584 GO:0051880 G-quadruplex DNA binding 2/2783 10/18639 0.2 1.33948975925261 0.453195687997638 0.833522111634584 GO:0071723 lipopeptide binding 2/2783 10/18639 0.2 1.33948975925261 0.453195687997638 0.833522111634584 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 2/2783 10/18639 0.2 1.33948975925261 0.453195687997638 0.833522111634584 GO:0098505 G-rich strand telomeric DNA binding 2/2783 10/18639 0.2 1.33948975925261 0.453195687997638 0.833522111634584 GO:0140999 histone H3K4 trimethyltransferase activity 2/2783 10/18639 0.2 1.33948975925261 0.453195687997638 0.833522111634584 GO:0141109 transporter activator activity 2/2783 10/18639 0.2 1.33948975925261 0.453195687997638 0.833522111634584 GO:1990763 arrestin family protein binding 2/2783 10/18639 0.2 1.33948975925261 0.453195687997638 0.833522111634584 GO:0005283 amino acid:sodium symporter activity 4/2783 23/18639 0.173913043478261 1.16477370369792 0.45665111250732 0.836181070526973 GO:0016849 phosphorus-oxygen lyase activity 4/2783 23/18639 0.173913043478261 1.16477370369792 0.45665111250732 0.836181070526973 GO:0017134 fibroblast growth factor binding 4/2783 23/18639 0.173913043478261 1.16477370369792 0.45665111250732 0.836181070526973 GO:0015171 amino acid transmembrane transporter activity 16/2783 102/18639 0.156862745098039 1.05058020333538 0.457206367550408 0.836181070526973 GO:0017022 myosin binding 12/2783 76/18639 0.157894736842105 1.05749191519943 0.465429573793434 0.84633360092498 GO:0008514 organic anion transmembrane transporter activity 41/2783 269/18639 0.152416356877323 1.02080074589883 0.469180478159398 0.84633360092498 GO:0015294 solute:monoatomic cation symporter activity 18/2783 116/18639 0.155172413793103 1.03925929597185 0.469196407876255 0.84633360092498 GO:0044325 transmembrane transporter binding 21/2783 136/18639 0.154411764705882 1.03416488765826 0.470240990305951 0.84633360092498 GO:0001965 G-protein alpha-subunit binding 5/2783 30/18639 0.166666666666667 1.11624146604384 0.471305502771621 0.84633360092498 GO:0016769 transferase activity, transferring nitrogenous groups 5/2783 30/18639 0.166666666666667 1.11624146604384 0.471305502771621 0.84633360092498 GO:0031210 phosphatidylcholine binding 5/2783 30/18639 0.166666666666667 1.11624146604384 0.471305502771621 0.84633360092498 GO:0031624 ubiquitin conjugating enzyme binding 5/2783 30/18639 0.166666666666667 1.11624146604384 0.471305502771621 0.84633360092498 GO:0033612 receptor serine/threonine kinase binding 5/2783 30/18639 0.166666666666667 1.11624146604384 0.471305502771621 0.84633360092498 GO:0051721 protein phosphatase 2A binding 5/2783 30/18639 0.166666666666667 1.11624146604384 0.471305502771621 0.84633360092498 GO:0048020 CCR chemokine receptor binding 8/2783 50/18639 0.16 1.07159180740208 0.475819207490809 0.84633360092498 GO:0004029 aldehyde dehydrogenase (NAD+) activity 3/2783 17/18639 0.176470588235294 1.1819027287523 0.477036193772899 0.84633360092498 GO:0004550 nucleoside diphosphate kinase activity 3/2783 17/18639 0.176470588235294 1.1819027287523 0.477036193772899 0.84633360092498 GO:0005092 GDP-dissociation inhibitor activity 3/2783 17/18639 0.176470588235294 1.1819027287523 0.477036193772899 0.84633360092498 GO:0017110 nucleoside diphosphate phosphatase activity 3/2783 17/18639 0.176470588235294 1.1819027287523 0.477036193772899 0.84633360092498 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 3/2783 17/18639 0.176470588235294 1.1819027287523 0.477036193772899 0.84633360092498 GO:0045125 bioactive lipid receptor activity 3/2783 17/18639 0.176470588235294 1.1819027287523 0.477036193772899 0.84633360092498 GO:0045236 CXCR chemokine receptor binding 3/2783 17/18639 0.176470588235294 1.1819027287523 0.477036193772899 0.84633360092498 GO:0046965 nuclear retinoid X receptor binding 3/2783 17/18639 0.176470588235294 1.1819027287523 0.477036193772899 0.84633360092498 GO:0048038 quinone binding 3/2783 17/18639 0.176470588235294 1.1819027287523 0.477036193772899 0.84633360092498 GO:0051787 misfolded protein binding 3/2783 17/18639 0.176470588235294 1.1819027287523 0.477036193772899 0.84633360092498 GO:0070403 NAD+ binding 3/2783 17/18639 0.176470588235294 1.1819027287523 0.477036193772899 0.84633360092498 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 20/2783 130/18639 0.153846153846154 1.03037673788662 0.479762689434952 0.850014330194535 GO:0004806 triacylglycerol lipase activity 4/2783 24/18639 0.166666666666667 1.11624146604384 0.49134813378356 0.861760968331645 GO:0005315 phosphate transmembrane transporter activity 4/2783 24/18639 0.166666666666667 1.11624146604384 0.49134813378356 0.861760968331645 GO:0019957 C-C chemokine binding 4/2783 24/18639 0.166666666666667 1.11624146604384 0.49134813378356 0.861760968331645 GO:0030552 cAMP binding 4/2783 24/18639 0.166666666666667 1.11624146604384 0.49134813378356 0.861760968331645 GO:0070300 phosphatidic acid binding 4/2783 24/18639 0.166666666666667 1.11624146604384 0.49134813378356 0.861760968331645 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 4/2783 24/18639 0.166666666666667 1.11624146604384 0.49134813378356 0.861760968331645 GO:0140033 acetylation-dependent protein binding 4/2783 24/18639 0.166666666666667 1.11624146604384 0.49134813378356 0.861760968331645 GO:0043014 alpha-tubulin binding 7/2783 44/18639 0.159090909090909 1.0655032175873 0.491679570888607 0.861760968331645 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 14/2783 91/18639 0.153846153846154 1.03037673788662 0.496500259307056 0.862323624445156 GO:0005021 vascular endothelial growth factor receptor activity 8/2783 51/18639 0.156862745098039 1.05058020333538 0.499423056361561 0.862323624445156 GO:0005048 signal sequence binding 8/2783 51/18639 0.156862745098039 1.05058020333538 0.499423056361561 0.862323624445156 GO:0016597 amino acid binding 8/2783 51/18639 0.156862745098039 1.05058020333538 0.499423056361561 0.862323624445156 GO:0030544 Hsp70 protein binding 8/2783 51/18639 0.156862745098039 1.05058020333538 0.499423056361561 0.862323624445156 GO:0008327 methyl-CpG binding 5/2783 31/18639 0.161290322580645 1.08023367681662 0.501693511199269 0.862323624445156 GO:0000099 sulfur amino acid transmembrane transporter activity 2/2783 11/18639 0.181818181818182 1.21771796295691 0.505226418003144 0.862323624445156 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 2/2783 11/18639 0.181818181818182 1.21771796295691 0.505226418003144 0.862323624445156 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 2/2783 11/18639 0.181818181818182 1.21771796295691 0.505226418003144 0.862323624445156 GO:0004954 prostanoid receptor activity 2/2783 11/18639 0.181818181818182 1.21771796295691 0.505226418003144 0.862323624445156 GO:0005225 volume-sensitive anion channel activity 2/2783 11/18639 0.181818181818182 1.21771796295691 0.505226418003144 0.862323624445156 GO:0010854 adenylate cyclase regulator activity 2/2783 11/18639 0.181818181818182 1.21771796295691 0.505226418003144 0.862323624445156 GO:0019107 myristoyltransferase activity 2/2783 11/18639 0.181818181818182 1.21771796295691 0.505226418003144 0.862323624445156 GO:0019203 carbohydrate phosphatase activity 2/2783 11/18639 0.181818181818182 1.21771796295691 0.505226418003144 0.862323624445156 GO:0019215 intermediate filament binding 2/2783 11/18639 0.181818181818182 1.21771796295691 0.505226418003144 0.862323624445156 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 2/2783 11/18639 0.181818181818182 1.21771796295691 0.505226418003144 0.862323624445156 GO:0043522 leucine zipper domain binding 2/2783 11/18639 0.181818181818182 1.21771796295691 0.505226418003144 0.862323624445156 GO:0048185 activin binding 2/2783 11/18639 0.181818181818182 1.21771796295691 0.505226418003144 0.862323624445156 GO:0050998 nitric-oxide synthase binding 2/2783 11/18639 0.181818181818182 1.21771796295691 0.505226418003144 0.862323624445156 GO:0180030 inositol phosphate kinase activity 2/2783 11/18639 0.181818181818182 1.21771796295691 0.505226418003144 0.862323624445156 GO:0061980 regulatory RNA binding 9/2783 58/18639 0.155172413793103 1.03925929597185 0.506166940053516 0.862799594548739 GO:0000146 microfilament motor activity 6/2783 38/18639 0.157894736842105 1.05749191519943 0.509893064470497 0.866884688486999 GO:0005109 frizzled binding 6/2783 38/18639 0.157894736842105 1.05749191519943 0.509893064470497 0.866884688486999 GO:0052689 carboxylic ester hydrolase activity 14/2783 92/18639 0.152173913043478 1.01917699073568 0.514005975231358 0.872739312111576 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 3/2783 18/18639 0.166666666666667 1.11624146604384 0.517085692249778 0.873942429004505 GO:0008308 voltage-gated monoatomic anion channel activity 3/2783 18/18639 0.166666666666667 1.11624146604384 0.517085692249778 0.873942429004505 GO:0015373 monoatomic anion:sodium symporter activity 3/2783 18/18639 0.166666666666667 1.11624146604384 0.517085692249778 0.873942429004505 GO:0016757 glycosyltransferase activity 40/2783 267/18639 0.149812734082397 1.00336311554502 0.517395364410643 0.873942429004505 GO:0008483 transaminase activity 4/2783 25/18639 0.16 1.07159180740208 0.525082036791459 0.88213006458777 GO:0015296 monoatomic anion:monoatomic cation symporter activity 4/2783 25/18639 0.16 1.07159180740208 0.525082036791459 0.88213006458777 GO:0047617 fatty acyl-CoA hydrolase activity 4/2783 25/18639 0.16 1.07159180740208 0.525082036791459 0.88213006458777 GO:0008378 galactosyltransferase activity 5/2783 32/18639 0.15625 1.0464763744161 0.531374706415385 0.88213006458777 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 5/2783 32/18639 0.15625 1.0464763744161 0.531374706415385 0.88213006458777 GO:0042910 xenobiotic transmembrane transporter activity 5/2783 32/18639 0.15625 1.0464763744161 0.531374706415385 0.88213006458777 GO:0070717 poly-purine tract binding 5/2783 32/18639 0.15625 1.0464763744161 0.531374706415385 0.88213006458777 GO:0120015 sterol transfer activity 5/2783 32/18639 0.15625 1.0464763744161 0.531374706415385 0.88213006458777 GO:0019783 ubiquitin-like protein peptidase activity 19/2783 127/18639 0.149606299212598 1.00198052857478 0.534556843866254 0.88213006458777 GO:0016776 phosphotransferase activity, phosphate group as acceptor 6/2783 39/18639 0.153846153846154 1.03037673788662 0.536691189344654 0.88213006458777 GO:0004866 endopeptidase inhibitor activity 24/2783 161/18639 0.149068322981366 0.998377460312501 0.537554863119704 0.88213006458777 GO:0016251 RNA polymerase II general transcription initiation factor activity 8/2783 53/18639 0.150943396226415 1.01093566736046 0.54557733760971 0.88213006458777 GO:0038064 collagen receptor activity 8/2783 53/18639 0.150943396226415 1.01093566736046 0.54557733760971 0.88213006458777 GO:0003697 single-stranded DNA binding 18/2783 121/18639 0.148760330578512 0.996314696964748 0.546029803420379 0.88213006458777 GO:0008083 growth factor activity 24/2783 162/18639 0.148148148148148 0.992214636483411 0.55062490021973 0.88213006458777 GO:0030414 peptidase inhibitor activity 25/2783 169/18639 0.14792899408284 0.990746863352519 0.55348399161203 0.88213006458777 GO:0000995 RNA polymerase III general transcription initiation factor activity 2/2783 12/18639 0.166666666666667 1.11624146604384 0.553915707043136 0.88213006458777 GO:0005025 transforming growth factor beta receptor activity, type I 2/2783 12/18639 0.166666666666667 1.11624146604384 0.553915707043136 0.88213006458777 GO:0005026 transforming growth factor beta receptor activity, type II 2/2783 12/18639 0.166666666666667 1.11624146604384 0.553915707043136 0.88213006458777 GO:0005095 GTPase inhibitor activity 2/2783 12/18639 0.166666666666667 1.11624146604384 0.553915707043136 0.88213006458777 GO:0005165 neurotrophin receptor binding 2/2783 12/18639 0.166666666666667 1.11624146604384 0.553915707043136 0.88213006458777 GO:0005527 macrolide binding 2/2783 12/18639 0.166666666666667 1.11624146604384 0.553915707043136 0.88213006458777 GO:0015132 prostaglandin transmembrane transporter activity 2/2783 12/18639 0.166666666666667 1.11624146604384 0.553915707043136 0.88213006458777 GO:0015166 polyol transmembrane transporter activity 2/2783 12/18639 0.166666666666667 1.11624146604384 0.553915707043136 0.88213006458777 GO:0016273 arginine N-methyltransferase activity 2/2783 12/18639 0.166666666666667 1.11624146604384 0.553915707043136 0.88213006458777 GO:0016274 protein-arginine N-methyltransferase activity 2/2783 12/18639 0.166666666666667 1.11624146604384 0.553915707043136 0.88213006458777 GO:0016361 activin receptor activity, type I 2/2783 12/18639 0.166666666666667 1.11624146604384 0.553915707043136 0.88213006458777 GO:0016362 activin receptor activity, type II 2/2783 12/18639 0.166666666666667 1.11624146604384 0.553915707043136 0.88213006458777 GO:0016801 hydrolase activity, acting on ether bonds 2/2783 12/18639 0.166666666666667 1.11624146604384 0.553915707043136 0.88213006458777 GO:0016803 ether hydrolase activity 2/2783 12/18639 0.166666666666667 1.11624146604384 0.553915707043136 0.88213006458777 GO:0017002 activin receptor activity 2/2783 12/18639 0.166666666666667 1.11624146604384 0.553915707043136 0.88213006458777 GO:0031543 peptidyl-proline dioxygenase activity 2/2783 12/18639 0.166666666666667 1.11624146604384 0.553915707043136 0.88213006458777 GO:0035251 UDP-glucosyltransferase activity 2/2783 12/18639 0.166666666666667 1.11624146604384 0.553915707043136 0.88213006458777 GO:0035497 cAMP response element binding 2/2783 12/18639 0.166666666666667 1.11624146604384 0.553915707043136 0.88213006458777 GO:0042301 phosphate ion binding 2/2783 12/18639 0.166666666666667 1.11624146604384 0.553915707043136 0.88213006458777 GO:0070679 inositol 1,4,5 trisphosphate binding 2/2783 12/18639 0.166666666666667 1.11624146604384 0.553915707043136 0.88213006458777 GO:1990247 N6-methyladenosine-containing RNA reader activity 2/2783 12/18639 0.166666666666667 1.11624146604384 0.553915707043136 0.88213006458777 GO:1990459 transferrin receptor binding 2/2783 12/18639 0.166666666666667 1.11624146604384 0.553915707043136 0.88213006458777 GO:0004843 cysteine-type deubiquitinase activity 16/2783 108/18639 0.148148148148148 0.992214636483411 0.555051265051997 0.88213006458777 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 3/2783 19/18639 0.157894736842105 1.05749191519943 0.55541484313017 0.88213006458777 GO:0008381 mechanosensitive monoatomic ion channel activity 3/2783 19/18639 0.157894736842105 1.05749191519943 0.55541484313017 0.88213006458777 GO:0008574 plus-end-directed microtubule motor activity 3/2783 19/18639 0.157894736842105 1.05749191519943 0.55541484313017 0.88213006458777 GO:0030506 ankyrin binding 3/2783 19/18639 0.157894736842105 1.05749191519943 0.55541484313017 0.88213006458777 GO:0042577 lipid phosphatase activity 3/2783 19/18639 0.157894736842105 1.05749191519943 0.55541484313017 0.88213006458777 GO:0042800 histone H3K4 methyltransferase activity 3/2783 19/18639 0.157894736842105 1.05749191519943 0.55541484313017 0.88213006458777 GO:0042834 peptidoglycan binding 3/2783 19/18639 0.157894736842105 1.05749191519943 0.55541484313017 0.88213006458777 GO:0050145 nucleoside monophosphate kinase activity 3/2783 19/18639 0.157894736842105 1.05749191519943 0.55541484313017 0.88213006458777 GO:0070003 threonine-type peptidase activity 3/2783 19/18639 0.157894736842105 1.05749191519943 0.55541484313017 0.88213006458777 GO:0031491 nucleosome binding 11/2783 74/18639 0.148648648648649 0.995566712958017 0.556383337695106 0.88213006458777 GO:0004112 cyclic-nucleotide phosphodiesterase activity 4/2783 26/18639 0.153846153846154 1.03037673788662 0.557692898736164 0.88213006458777 GO:0015145 monosaccharide transmembrane transporter activity 4/2783 26/18639 0.153846153846154 1.03037673788662 0.557692898736164 0.88213006458777 GO:0016289 acyl-CoA hydrolase activity 4/2783 26/18639 0.153846153846154 1.03037673788662 0.557692898736164 0.88213006458777 GO:0101005 deubiquitinase activity 17/2783 115/18639 0.147826086956522 0.99005764814323 0.558096091476158 0.88213006458777 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 5/2783 33/18639 0.151515151515152 1.01476496913076 0.560231658197027 0.883364065645615 GO:0071889 14-3-3 protein binding 5/2783 33/18639 0.151515151515152 1.01476496913076 0.560231658197027 0.883364065645615 GO:0050997 quaternary ammonium group binding 6/2783 40/18639 0.15 1.00461731943945 0.562840845362154 0.886406355497886 GO:0003777 microtubule motor activity 10/2783 68/18639 0.147058823529412 0.984918940626916 0.572950640448118 0.90123960813552 GO:0008266 poly(U) RNA binding 4/2783 27/18639 0.148148148148148 0.992214636483411 0.589053331927654 0.92343726354003 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 4/2783 27/18639 0.148148148148148 0.992214636483411 0.589053331927654 0.92343726354003 GO:0005326 neurotransmitter transmembrane transporter activity 3/2783 20/18639 0.15 1.00461731943945 0.59185744516771 0.92343726354003 GO:0005262 calcium channel activity 19/2783 131/18639 0.145038167938931 0.97138570327479 0.592400608303655 0.92343726354003 GO:0008194 UDP-glycosyltransferase activity 21/2783 145/18639 0.144827586206897 0.969975342907059 0.596214256885526 0.92343726354003 GO:0004465 lipoprotein lipase activity 2/2783 13/18639 0.153846153846154 1.03037673788662 0.599101169443915 0.92343726354003 GO:0004535 poly(A)-specific ribonuclease activity 2/2783 13/18639 0.153846153846154 1.03037673788662 0.599101169443915 0.92343726354003 GO:0005542 folic acid binding 2/2783 13/18639 0.153846153846154 1.03037673788662 0.599101169443915 0.92343726354003 GO:0008253 5'-nucleotidase activity 2/2783 13/18639 0.153846153846154 1.03037673788662 0.599101169443915 0.92343726354003 GO:0015651 quaternary ammonium group transmembrane transporter activity 2/2783 13/18639 0.153846153846154 1.03037673788662 0.599101169443915 0.92343726354003 GO:0031432 titin binding 2/2783 13/18639 0.153846153846154 1.03037673788662 0.599101169443915 0.92343726354003 GO:0031994 insulin-like growth factor I binding 2/2783 13/18639 0.153846153846154 1.03037673788662 0.599101169443915 0.92343726354003 GO:0035673 oligopeptide transmembrane transporter activity 2/2783 13/18639 0.153846153846154 1.03037673788662 0.599101169443915 0.92343726354003 GO:0045159 myosin II binding 2/2783 13/18639 0.153846153846154 1.03037673788662 0.599101169443915 0.92343726354003 GO:0061459 L-arginine transmembrane transporter activity 2/2783 13/18639 0.153846153846154 1.03037673788662 0.599101169443915 0.92343726354003 GO:0140410 monoatomic cation:bicarbonate symporter activity 2/2783 13/18639 0.153846153846154 1.03037673788662 0.599101169443915 0.92343726354003 GO:0140852 histone ubiquitin ligase activity 2/2783 13/18639 0.153846153846154 1.03037673788662 0.599101169443915 0.92343726354003 GO:0005343 organic acid:sodium symporter activity 5/2783 35/18639 0.142857142857143 0.956778399466147 0.615097901990414 0.945858094570164 GO:0016229 steroid dehydrogenase activity 5/2783 35/18639 0.142857142857143 0.956778399466147 0.615097901990414 0.945858094570164 GO:0051119 sugar transmembrane transporter activity 4/2783 28/18639 0.142857142857143 0.956778399466147 0.619066009558267 0.948604085151563 GO:0051537 2 iron, 2 sulfur cluster binding 4/2783 28/18639 0.142857142857143 0.956778399466147 0.619066009558267 0.948604085151563 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 4/2783 28/18639 0.142857142857143 0.956778399466147 0.619066009558267 0.948604085151563 GO:0015085 calcium ion transmembrane transporter activity 21/2783 147/18639 0.142857142857143 0.956778399466147 0.622612087545268 0.952918030703086 GO:0015174 basic amino acid transmembrane transporter activity 3/2783 21/18639 0.142857142857143 0.956778399466147 0.626303403816437 0.956322761799336 GO:0051428 peptide hormone receptor binding 3/2783 21/18639 0.142857142857143 0.956778399466147 0.626303403816437 0.956322761799336 GO:0140299 molecular sensor activity 10/2783 71/18639 0.140845070422535 0.94330264736099 0.630255670835191 0.961232040665601 GO:0015932 nucleobase-containing compound transmembrane transporter activity 8/2783 57/18639 0.140350877192982 0.9399928135106 0.632056143948543 0.962851882837501 GO:0004065 arylsulfatase activity 2/2783 14/18639 0.142857142857143 0.956778399466147 0.640743351844075 0.962923436885922 GO:0005313 L-glutamate transmembrane transporter activity 2/2783 14/18639 0.142857142857143 0.956778399466147 0.640743351844075 0.962923436885922 GO:0008195 phosphatidate phosphatase activity 2/2783 14/18639 0.142857142857143 0.956778399466147 0.640743351844075 0.962923436885922 GO:0019992 diacylglycerol binding 2/2783 14/18639 0.142857142857143 0.956778399466147 0.640743351844075 0.962923436885922 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 2/2783 14/18639 0.142857142857143 0.956778399466147 0.640743351844075 0.962923436885922 GO:0030983 mismatched DNA binding 2/2783 14/18639 0.142857142857143 0.956778399466147 0.640743351844075 0.962923436885922 GO:0031404 chloride ion binding 2/2783 14/18639 0.142857142857143 0.956778399466147 0.640743351844075 0.962923436885922 GO:0042043 neurexin family protein binding 2/2783 14/18639 0.142857142857143 0.956778399466147 0.640743351844075 0.962923436885922 GO:0042813 Wnt receptor activity 2/2783 14/18639 0.142857142857143 0.956778399466147 0.640743351844075 0.962923436885922 GO:0098821 BMP receptor activity 2/2783 14/18639 0.142857142857143 0.956778399466147 0.640743351844075 0.962923436885922 GO:0000993 RNA polymerase II complex binding 5/2783 36/18639 0.138888888888889 0.930201221703198 0.640964373632654 0.962923436885922 GO:0044390 ubiquitin-like protein conjugating enzyme binding 5/2783 36/18639 0.138888888888889 0.930201221703198 0.640964373632654 0.962923436885922 GO:0005416 amino acid:monoatomic cation symporter activity 4/2783 29/18639 0.137931034482759 0.923786040863866 0.64766092642021 0.969632431747363 GO:0043236 laminin binding 4/2783 29/18639 0.137931034482759 0.923786040863866 0.64766092642021 0.969632431747363 GO:0106222 lncRNA binding 4/2783 29/18639 0.137931034482759 0.923786040863866 0.64766092642021 0.969632431747363 GO:0120013 lipid transfer activity 9/2783 65/18639 0.138461538461538 0.927339064097957 0.649996898395023 0.970900292677102 GO:0160215 deacylase activity 9/2783 65/18639 0.138461538461538 0.927339064097957 0.649996898395023 0.970900292677102 GO:0005010 insulin-like growth factor receptor activity 7/2783 51/18639 0.137254901960784 0.919257677918455 0.655268867632302 0.977655152623023 GO:0008093 cytoskeletal anchor activity 3/2783 22/18639 0.136363636363636 0.913288472217685 0.658690445656674 0.979398336529422 GO:0030021 extracellular matrix structural constituent conferring compression resistance 3/2783 22/18639 0.136363636363636 0.913288472217685 0.658690445656674 0.979398336529422 GO:0140517 protein-RNA adaptor activity 3/2783 22/18639 0.136363636363636 0.913288472217685 0.658690445656674 0.979398336529422 GO:0005319 lipid transporter activity 25/2783 178/18639 0.140449438202247 0.940652920823459 0.662378645869832 0.983760540107358 GO:0019213 deacetylase activity 5/2783 37/18639 0.135135135135135 0.905060648143652 0.665718662078376 0.986474017443412 GO:0030551 cyclic nucleotide binding 5/2783 37/18639 0.135135135135135 0.905060648143652 0.665718662078376 0.986474017443412 GO:0008187 poly-pyrimidine tract binding 4/2783 30/18639 0.133333333333333 0.89299317283507 0.674792530058454 0.991350542589036 GO:0070566 adenylyltransferase activity 4/2783 30/18639 0.133333333333333 0.89299317283507 0.674792530058454 0.991350542589036 GO:0004089 carbonate dehydratase activity 2/2783 15/18639 0.133333333333333 0.89299317283507 0.678892664518412 0.991350542589036 GO:0004129 cytochrome-c oxidase activity 2/2783 15/18639 0.133333333333333 0.89299317283507 0.678892664518412 0.991350542589036 GO:0004953 icosanoid receptor activity 2/2783 15/18639 0.133333333333333 0.89299317283507 0.678892664518412 0.991350542589036 GO:0005523 tropomyosin binding 2/2783 15/18639 0.133333333333333 0.89299317283507 0.678892664518412 0.991350542589036 GO:0008252 nucleotidase activity 2/2783 15/18639 0.133333333333333 0.89299317283507 0.678892664518412 0.991350542589036 GO:0010181 FMN binding 2/2783 15/18639 0.133333333333333 0.89299317283507 0.678892664518412 0.991350542589036 GO:0015250 water channel activity 2/2783 15/18639 0.133333333333333 0.89299317283507 0.678892664518412 0.991350542589036 GO:0016846 carbon-sulfur lyase activity 2/2783 15/18639 0.133333333333333 0.89299317283507 0.678892664518412 0.991350542589036 GO:0031005 filamin binding 2/2783 15/18639 0.133333333333333 0.89299317283507 0.678892664518412 0.991350542589036 GO:0045504 dynein heavy chain binding 2/2783 15/18639 0.133333333333333 0.89299317283507 0.678892664518412 0.991350542589036 GO:0140776 protein-containing complex destabilizing activity 2/2783 15/18639 0.133333333333333 0.89299317283507 0.678892664518412 0.991350542589036 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 9/2783 67/18639 0.134328358208955 0.899657300990556 0.686430095663119 0.996546004265271 GO:0042054 histone methyltransferase activity 9/2783 67/18639 0.134328358208955 0.899657300990556 0.686430095663119 0.996546004265271 GO:0003887 DNA-directed DNA polymerase activity 3/2783 23/18639 0.130434782608696 0.873580277773438 0.688996345629078 0.996546004265271 GO:0005212 structural constituent of eye lens 3/2783 23/18639 0.130434782608696 0.873580277773438 0.688996345629078 0.996546004265271 GO:0016493 C-C chemokine receptor activity 3/2783 23/18639 0.130434782608696 0.873580277773438 0.688996345629078 0.996546004265271 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 3/2783 23/18639 0.130434782608696 0.873580277773438 0.688996345629078 0.996546004265271 GO:0070577 lysine-acetylated histone binding 3/2783 23/18639 0.130434782608696 0.873580277773438 0.688996345629078 0.996546004265271 GO:0140103 catalytic activity, acting on a glycoprotein 3/2783 23/18639 0.130434782608696 0.873580277773438 0.688996345629078 0.996546004265271 GO:0042162 telomeric DNA binding 5/2783 38/18639 0.131578947368421 0.881243262666188 0.689328601109873 0.996546004265271 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 8/2783 60/18639 0.133333333333333 0.89299317283507 0.690491133873422 0.997121194430722 GO:0003727 single-stranded RNA binding 12/2783 89/18639 0.134831460674157 0.90302680399052 0.694121802869936 1 GO:0003823 antigen binding 24/2783 174/18639 0.137931034482759 0.923786040863866 0.6956585220396 1 GO:0005003 ephrin receptor activity 7/2783 53/18639 0.132075471698113 0.8845687089404 0.695721407333192 1 GO:0005005 transmembrane-ephrin receptor activity 7/2783 53/18639 0.132075471698113 0.8845687089404 0.695721407333192 1 GO:0005310 dicarboxylic acid transmembrane transporter activity 4/2783 31/18639 0.129032258064516 0.864186941453294 0.700436829148704 1 GO:0017147 Wnt-protein binding 4/2783 31/18639 0.129032258064516 0.864186941453294 0.700436829148704 1 GO:0072349 modified amino acid transmembrane transporter activity 4/2783 31/18639 0.129032258064516 0.864186941453294 0.700436829148704 1 GO:0140223 general transcription initiation factor activity 9/2783 68/18639 0.132352941176471 0.886427046564224 0.703740521034899 1 GO:0005201 extracellular matrix structural constituent 23/2783 168/18639 0.136904761904762 0.916912632821724 0.706933388558376 1 GO:0005506 iron ion binding 21/2783 154/18639 0.136363636363636 0.913288472217685 0.708154665306983 1 GO:0016836 hydro-lyase activity 8/2783 61/18639 0.131147540983607 0.878353940493512 0.708601895194993 1 GO:0019841 retinol binding 2/2783 16/18639 0.125 0.837181099532878 0.713663441896653 1 GO:0097027 ubiquitin-protein transferase activator activity 2/2783 16/18639 0.125 0.837181099532878 0.713663441896653 1 GO:0140327 flippase activity 2/2783 16/18639 0.125 0.837181099532878 0.713663441896653 1 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 3/2783 24/18639 0.125 0.837181099532878 0.717231804464152 1 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 3/2783 24/18639 0.125 0.837181099532878 0.717231804464152 1 GO:0015149 hexose transmembrane transporter activity 3/2783 24/18639 0.125 0.837181099532878 0.717231804464152 1 GO:0055056 D-glucose transmembrane transporter activity 3/2783 24/18639 0.125 0.837181099532878 0.717231804464152 1 GO:0004386 helicase activity 21/2783 155/18639 0.135483870967742 0.907396288525958 0.719394932024798 1 GO:0043495 protein-membrane adaptor activity 6/2783 47/18639 0.127659574468085 0.854993463352727 0.722641317487953 1 GO:0140359 ABC-type transporter activity 6/2783 47/18639 0.127659574468085 0.854993463352727 0.722641317487953 1 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 5/2783 40/18639 0.125 0.837181099532878 0.733051627017567 1 GO:1901682 sulfur compound transmembrane transporter activity 8/2783 63/18639 0.126984126984127 0.850469688414352 0.742691486240736 1 GO:0005537 D-mannose binding 3/2783 25/18639 0.12 0.803693855551563 0.743434045510428 1 GO:0015662 P-type ion transporter activity 3/2783 25/18639 0.12 0.803693855551563 0.743434045510428 1 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 3/2783 25/18639 0.12 0.803693855551563 0.743434045510428 1 GO:0140358 P-type transmembrane transporter activity 3/2783 25/18639 0.12 0.803693855551563 0.743434045510428 1 GO:0008569 minus-end-directed microtubule motor activity 2/2783 17/18639 0.117647058823529 0.787935152501532 0.745213741646486 1 GO:0015278 intracellularly gated calcium channel activity 2/2783 17/18639 0.117647058823529 0.787935152501532 0.745213741646486 1 GO:0015347 sodium-independent organic anion transmembrane transporter activity 2/2783 17/18639 0.117647058823529 0.787935152501532 0.745213741646486 1 GO:0030548 acetylcholine receptor regulator activity 2/2783 17/18639 0.117647058823529 0.787935152501532 0.745213741646486 1 GO:0038191 neuropilin binding 2/2783 17/18639 0.117647058823529 0.787935152501532 0.745213741646486 1 GO:0070492 oligosaccharide binding 2/2783 17/18639 0.117647058823529 0.787935152501532 0.745213741646486 1 GO:0008201 heparin binding 23/2783 172/18639 0.133720930232558 0.895589083221218 0.748707569065256 1 GO:0004175 endopeptidase activity 56/2783 405/18639 0.138271604938272 0.926066994051184 0.755722958750098 1 GO:0005004 GPI-linked ephrin receptor activity 6/2783 49/18639 0.122448979591837 0.820095770970983 0.759882697161225 1 GO:0005008 hepatocyte growth factor receptor activity 6/2783 49/18639 0.122448979591837 0.820095770970983 0.759882697161225 1 GO:0005009 insulin receptor activity 6/2783 49/18639 0.122448979591837 0.820095770970983 0.759882697161225 1 GO:0005011 macrophage colony-stimulating factor receptor activity 6/2783 49/18639 0.122448979591837 0.820095770970983 0.759882697161225 1 GO:0005018 platelet-derived growth factor alpha-receptor activity 6/2783 49/18639 0.122448979591837 0.820095770970983 0.759882697161225 1 GO:0005020 stem cell factor receptor activity 6/2783 49/18639 0.122448979591837 0.820095770970983 0.759882697161225 1 GO:0008288 boss receptor activity 6/2783 49/18639 0.122448979591837 0.820095770970983 0.759882697161225 1 GO:0036332 placental growth factor receptor activity 6/2783 49/18639 0.122448979591837 0.820095770970983 0.759882697161225 1 GO:0038062 protein tyrosine kinase collagen receptor activity 6/2783 49/18639 0.122448979591837 0.820095770970983 0.759882697161225 1 GO:0060175 brain-derived neurotrophic factor receptor activity 6/2783 49/18639 0.122448979591837 0.820095770970983 0.759882697161225 1 GO:0046906 tetrapyrrole binding 20/2783 152/18639 0.131578947368421 0.881243262666188 0.763531566287662 1 GO:0001637 G protein-coupled chemoattractant receptor activity 3/2783 26/18639 0.115384615384615 0.772782553414964 0.767661151611418 1 GO:0004529 DNA exonuclease activity 3/2783 26/18639 0.115384615384615 0.772782553414964 0.767661151611418 1 GO:0004950 chemokine receptor activity 3/2783 26/18639 0.115384615384615 0.772782553414964 0.767661151611418 1 GO:0005227 calcium-activated cation channel activity 3/2783 26/18639 0.115384615384615 0.772782553414964 0.767661151611418 1 GO:0008143 poly(A) binding 3/2783 26/18639 0.115384615384615 0.772782553414964 0.767661151611418 1 GO:0030507 spectrin binding 3/2783 26/18639 0.115384615384615 0.772782553414964 0.767661151611418 1 GO:0015020 glucuronosyltransferase activity 4/2783 34/18639 0.117647058823529 0.787935152501532 0.76847080068367 1 GO:0090482 vitamin transmembrane transporter activity 4/2783 34/18639 0.117647058823529 0.787935152501532 0.76847080068367 1 GO:0019894 kinesin binding 5/2783 42/18639 0.119047619047619 0.797315332888455 0.772115907683808 1 GO:0031492 nucleosomal DNA binding 5/2783 42/18639 0.119047619047619 0.797315332888455 0.772115907683808 1 GO:0035198 miRNA binding 5/2783 42/18639 0.119047619047619 0.797315332888455 0.772115907683808 1 GO:0051879 Hsp90 protein binding 5/2783 42/18639 0.119047619047619 0.797315332888455 0.772115907683808 1 GO:0005372 water transmembrane transporter activity 2/2783 18/18639 0.111111111111111 0.744160977362558 0.773729747821075 1 GO:0008409 5'-3' exonuclease activity 2/2783 18/18639 0.111111111111111 0.744160977362558 0.773729747821075 1 GO:0015280 ligand-gated sodium channel activity 2/2783 18/18639 0.111111111111111 0.744160977362558 0.773729747821075 1 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 2/2783 18/18639 0.111111111111111 0.744160977362558 0.773729747821075 1 GO:0070628 proteasome binding 2/2783 18/18639 0.111111111111111 0.744160977362558 0.773729747821075 1 GO:0099602 neurotransmitter receptor regulator activity 2/2783 18/18639 0.111111111111111 0.744160977362558 0.773729747821075 1 GO:0005006 epidermal growth factor receptor activity 6/2783 50/18639 0.12 0.803693855551563 0.777065119580664 1 GO:0005007 fibroblast growth factor receptor activity 6/2783 50/18639 0.12 0.803693855551563 0.777065119580664 1 GO:0005017 platelet-derived growth factor receptor activity 6/2783 50/18639 0.12 0.803693855551563 0.777065119580664 1 GO:0005019 platelet-derived growth factor beta-receptor activity 6/2783 50/18639 0.12 0.803693855551563 0.777065119580664 1 GO:0004521 RNA endonuclease activity 9/2783 73/18639 0.123287671232877 0.825712865292702 0.78083351838519 1 GO:0005179 hormone activity 17/2783 132/18639 0.128787878787879 0.862550223761147 0.781028437058253 1 GO:0042393 histone binding 33/2783 247/18639 0.133603238866397 0.894800851322591 0.782123662378834 1 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 5/2783 43/18639 0.116279069767442 0.778773115844538 0.789936539724225 1 GO:0015252 proton channel activity 3/2783 27/18639 0.111111111111111 0.744160977362558 0.789987129071889 1 GO:0017171 serine hydrolase activity 26/2783 198/18639 0.131313131313131 0.87946297324666 0.790158868137566 1 GO:0005030 neurotrophin receptor activity 6/2783 51/18639 0.117647058823529 0.787935152501532 0.793304619840445 1 GO:0008237 metallopeptidase activity 24/2783 184/18639 0.130434782608696 0.873580277773438 0.79345669120863 1 GO:0043021 ribonucleoprotein complex binding 23/2783 177/18639 0.129943502824859 0.870289956576551 0.795326979651871 1 GO:0005539 glycosaminoglycan binding 32/2783 242/18639 0.132231404958678 0.885613063968664 0.798207319044312 1 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 2/2783 19/18639 0.105263157894737 0.70499461013295 0.799413854255299 1 GO:0005229 intracellularly calcium-gated chloride channel activity 2/2783 19/18639 0.105263157894737 0.70499461013295 0.799413854255299 1 GO:0005346 purine ribonucleotide transmembrane transporter activity 2/2783 19/18639 0.105263157894737 0.70499461013295 0.799413854255299 1 GO:0005520 insulin-like growth factor binding 2/2783 19/18639 0.105263157894737 0.70499461013295 0.799413854255299 1 GO:0008301 DNA binding, bending 2/2783 19/18639 0.105263157894737 0.70499461013295 0.799413854255299 1 GO:0016918 retinal binding 2/2783 19/18639 0.105263157894737 0.70499461013295 0.799413854255299 1 GO:0031420 alkali metal ion binding 2/2783 19/18639 0.105263157894737 0.70499461013295 0.799413854255299 1 GO:0046527 glucosyltransferase activity 2/2783 19/18639 0.105263157894737 0.70499461013295 0.799413854255299 1 GO:0046624 sphingolipid transporter activity 2/2783 19/18639 0.105263157894737 0.70499461013295 0.799413854255299 1 GO:0141147 intracellularly calcium-gated channel activity 2/2783 19/18639 0.105263157894737 0.70499461013295 0.799413854255299 1 GO:0000182 rDNA binding 1/2783 10/18639 0.1 0.669744879626303 0.801607071632634 1 GO:0003680 minor groove of adenine-thymine-rich DNA binding 1/2783 10/18639 0.1 0.669744879626303 0.801607071632634 1 GO:0003796 lysozyme activity 1/2783 10/18639 0.1 0.669744879626303 0.801607071632634 1 GO:0004935 adrenergic receptor activity 1/2783 10/18639 0.1 0.669744879626303 0.801607071632634 1 GO:0005031 tumor necrosis factor receptor activity 1/2783 10/18639 0.1 0.669744879626303 0.801607071632634 1 GO:0005337 nucleoside transmembrane transporter activity 1/2783 10/18639 0.1 0.669744879626303 0.801607071632634 1 GO:0005528 FK506 binding 1/2783 10/18639 0.1 0.669744879626303 0.801607071632634 1 GO:0008239 dipeptidyl-peptidase activity 1/2783 10/18639 0.1 0.669744879626303 0.801607071632634 1 GO:0015643 toxic substance binding 1/2783 10/18639 0.1 0.669744879626303 0.801607071632634 1 GO:0015658 branched-chain amino acid transmembrane transporter activity 1/2783 10/18639 0.1 0.669744879626303 0.801607071632634 1 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 1/2783 10/18639 0.1 0.669744879626303 0.801607071632634 1 GO:0019911 structural constituent of myelin sheath 1/2783 10/18639 0.1 0.669744879626303 0.801607071632634 1 GO:0031956 medium-chain fatty acid-CoA ligase activity 1/2783 10/18639 0.1 0.669744879626303 0.801607071632634 1 GO:0032052 bile acid binding 1/2783 10/18639 0.1 0.669744879626303 0.801607071632634 1 GO:0032356 oxidized DNA binding 1/2783 10/18639 0.1 0.669744879626303 0.801607071632634 1 GO:0042975 peroxisome proliferator activated receptor binding 1/2783 10/18639 0.1 0.669744879626303 0.801607071632634 1 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 1/2783 10/18639 0.1 0.669744879626303 0.801607071632634 1 GO:0043295 glutathione binding 1/2783 10/18639 0.1 0.669744879626303 0.801607071632634 1 GO:0051378 serotonin binding 1/2783 10/18639 0.1 0.669744879626303 0.801607071632634 1 GO:0070739 protein-glutamic acid ligase activity 1/2783 10/18639 0.1 0.669744879626303 0.801607071632634 1 GO:0070740 tubulin-glutamic acid ligase activity 1/2783 10/18639 0.1 0.669744879626303 0.801607071632634 1 GO:0099122 RNA polymerase II C-terminal domain binding 1/2783 10/18639 0.1 0.669744879626303 0.801607071632634 1 GO:0140940 histone H2A methyltransferase activity 1/2783 10/18639 0.1 0.669744879626303 0.801607071632634 1 GO:1990259 histone H2AQ104 methyltransferase activity 1/2783 10/18639 0.1 0.669744879626303 0.801607071632634 1 GO:1990757 ubiquitin ligase activator activity 1/2783 10/18639 0.1 0.669744879626303 0.801607071632634 1 GO:0004033 aldo-keto reductase (NADPH) activity 4/2783 36/18639 0.111111111111111 0.744160977362558 0.806672911939874 1 GO:0004869 cysteine-type endopeptidase inhibitor activity 4/2783 36/18639 0.111111111111111 0.744160977362558 0.806672911939874 1 GO:0055106 ubiquitin-protein transferase regulator activity 4/2783 36/18639 0.111111111111111 0.744160977362558 0.806672911939874 1 GO:0045499 chemorepellent activity 3/2783 28/18639 0.107142857142857 0.71758379959961 0.810497663413524 1 GO:0050698 proteoglycan sulfotransferase activity 3/2783 28/18639 0.107142857142857 0.71758379959961 0.810497663413524 1 GO:0051393 alpha-actinin binding 3/2783 28/18639 0.107142857142857 0.71758379959961 0.810497663413524 1 GO:0008236 serine-type peptidase activity 25/2783 194/18639 0.128865979381443 0.863073298487503 0.816097819010445 1 GO:0004540 RNA nuclease activity 15/2783 121/18639 0.12396694214876 0.830262247470623 0.818168022414359 1 GO:0140658 ATP-dependent chromatin remodeler activity 20/2783 158/18639 0.126582278481013 0.847778328640889 0.819517018367662 1 GO:0016779 nucleotidyltransferase activity 17/2783 136/18639 0.125 0.837181099532878 0.820013195966285 1 GO:0016853 isomerase activity 23/2783 180/18639 0.127777777777778 0.855785123966942 0.820259643248787 1 GO:0000510 H3-H4 histone complex chaperone activity 19/2783 151/18639 0.125827814569536 0.842725345225149 0.82238635688215 1 GO:0140584 chromatin extrusion motor activity 19/2783 151/18639 0.125827814569536 0.842725345225149 0.82238635688215 1 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 19/2783 151/18639 0.125827814569536 0.842725345225149 0.82238635688215 1 GO:0140849 ATP-dependent H2AZ histone chaperone activity 19/2783 151/18639 0.125827814569536 0.842725345225149 0.82238635688215 1 GO:0001972 retinoic acid binding 2/2783 20/18639 0.1 0.669744879626303 0.822475677487253 1 GO:0010851 cyclase regulator activity 2/2783 20/18639 0.1 0.669744879626303 0.822475677487253 1 GO:0016408 C-acyltransferase activity 2/2783 20/18639 0.1 0.669744879626303 0.822475677487253 1 GO:0030742 GTP-dependent protein binding 2/2783 20/18639 0.1 0.669744879626303 0.822475677487253 1 GO:0016860 intramolecular oxidoreductase activity 6/2783 53/18639 0.113207547169811 0.758201750520343 0.823031946000341 1 GO:0004527 exonuclease activity 10/2783 84/18639 0.119047619047619 0.797315332888455 0.823781062503118 1 GO:0140597 protein carrier chaperone 24/2783 188/18639 0.127659574468085 0.854993463352727 0.82583091612465 1 GO:0016279 protein-lysine N-methyltransferase activity 8/2783 69/18639 0.115942028985507 0.776515802465278 0.827878959503364 1 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 23/2783 181/18639 0.12707182320442 0.85105702935939 0.828067458973228 1 GO:0004181 metallocarboxypeptidase activity 3/2783 29/18639 0.103448275862069 0.692839530647899 0.829286517681983 1 GO:0099604 ligand-gated calcium channel activity 3/2783 29/18639 0.103448275862069 0.692839530647899 0.829286517681983 1 GO:0015616 DNA translocase activity 19/2783 152/18639 0.125 0.837181099532878 0.830794184109934 1 GO:0140674 ATP-dependent histone chaperone activity 19/2783 152/18639 0.125 0.837181099532878 0.830794184109934 1 GO:0003724 RNA helicase activity 9/2783 77/18639 0.116883116883117 0.782818690472302 0.831167416394042 1 GO:0002162 dystroglycan binding 1/2783 11/18639 0.0909090909090909 0.608858981478457 0.831245136995583 1 GO:0004016 adenylate cyclase activity 1/2783 11/18639 0.0909090909090909 0.608858981478457 0.831245136995583 1 GO:0005221 intracellularly cyclic nucleotide-activated monoatomic cation channel activity 1/2783 11/18639 0.0909090909090909 0.608858981478457 0.831245136995583 1 GO:0005536 D-glucose binding 1/2783 11/18639 0.0909090909090909 0.608858981478457 0.831245136995583 1 GO:0008046 axon guidance receptor activity 1/2783 11/18639 0.0909090909090909 0.608858981478457 0.831245136995583 1 GO:0008172 S-methyltransferase activity 1/2783 11/18639 0.0909090909090909 0.608858981478457 0.831245136995583 1 GO:0008271 secondary active sulfate transmembrane transporter activity 1/2783 11/18639 0.0909090909090909 0.608858981478457 0.831245136995583 1 GO:0008526 phosphatidylinositol transfer activity 1/2783 11/18639 0.0909090909090909 0.608858981478457 0.831245136995583 1 GO:0015173 aromatic amino acid transmembrane transporter activity 1/2783 11/18639 0.0909090909090909 0.608858981478457 0.831245136995583 1 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 1/2783 11/18639 0.0909090909090909 0.608858981478457 0.831245136995583 1 GO:0031731 CCR6 chemokine receptor binding 1/2783 11/18639 0.0909090909090909 0.608858981478457 0.831245136995583 1 GO:0032404 mismatch repair complex binding 1/2783 11/18639 0.0909090909090909 0.608858981478457 0.831245136995583 1 GO:0034056 estrogen response element binding 1/2783 11/18639 0.0909090909090909 0.608858981478457 0.831245136995583 1 GO:0035252 UDP-xylosyltransferase activity 1/2783 11/18639 0.0909090909090909 0.608858981478457 0.831245136995583 1 GO:0042285 xylosyltransferase activity 1/2783 11/18639 0.0909090909090909 0.608858981478457 0.831245136995583 1 GO:0043855 cyclic nucleotide-activated monoatomic ion channel activity 1/2783 11/18639 0.0909090909090909 0.608858981478457 0.831245136995583 1 GO:0048407 platelet-derived growth factor binding 1/2783 11/18639 0.0909090909090909 0.608858981478457 0.831245136995583 1 GO:0070990 snRNP binding 1/2783 11/18639 0.0909090909090909 0.608858981478457 0.831245136995583 1 GO:0099528 G protein-coupled neurotransmitter receptor activity 1/2783 11/18639 0.0909090909090909 0.608858981478457 0.831245136995583 1 GO:1900750 oligopeptide binding 1/2783 11/18639 0.0909090909090909 0.608858981478457 0.831245136995583 1 GO:1990948 ubiquitin ligase inhibitor activity 1/2783 11/18639 0.0909090909090909 0.608858981478457 0.831245136995583 1 GO:0003689 DNA clamp loader activity 20/2783 160/18639 0.125 0.837181099532878 0.835875205164415 1 GO:0050661 NADP binding 6/2783 54/18639 0.111111111111111 0.744160977362558 0.836568023597652 1 GO:0051287 NAD binding 6/2783 54/18639 0.111111111111111 0.744160977362558 0.836568023597652 1 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 5/2783 46/18639 0.108695652173913 0.727983564811198 0.836886959714237 1 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 5/2783 46/18639 0.108695652173913 0.727983564811198 0.836886959714237 1 GO:0016758 hexosyltransferase activity 25/2783 197/18639 0.126903553299492 0.849930050287186 0.838368502360567 1 GO:0061775 cohesin loader activity 19/2783 153/18639 0.124183006535948 0.831709327640506 0.83890550423096 1 GO:0005501 retinoid binding 4/2783 38/18639 0.105263157894737 0.70499461013295 0.839573531377047 1 GO:0019840 isoprenoid binding 4/2783 38/18639 0.105263157894737 0.70499461013295 0.839573531377047 1 GO:0016278 lysine N-methyltransferase activity 8/2783 70/18639 0.114285714285714 0.765422719572917 0.839671683869293 1 GO:0015125 bile acid transmembrane transporter activity 2/2783 21/18639 0.0952380952380952 0.637852266310764 0.843125390505234 1 GO:0019200 carbohydrate kinase activity 2/2783 21/18639 0.0952380952380952 0.637852266310764 0.843125390505234 1 GO:0036122 BMP binding 2/2783 21/18639 0.0952380952380952 0.637852266310764 0.843125390505234 1 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 3/2783 30/18639 0.1 0.669744879626303 0.84645251630682 1 GO:0008106 alcohol dehydrogenase (NADP+) activity 3/2783 30/18639 0.1 0.669744879626303 0.84645251630682 1 GO:0022839 monoatomic ion-gated channel activity 3/2783 30/18639 0.1 0.669744879626303 0.84645251630682 1 GO:0048019 receptor antagonist activity 3/2783 30/18639 0.1 0.669744879626303 0.84645251630682 1 GO:0042562 hormone binding 11/2783 94/18639 0.117021276595745 0.783744008073333 0.848334250160965 1 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 16/2783 132/18639 0.121212121212121 0.811811975304609 0.849615582325681 1 GO:0008186 ATP-dependent activity, acting on RNA 9/2783 79/18639 0.113924050632911 0.7630004957768 0.852731624414445 1 GO:0015370 solute:sodium symporter activity 9/2783 79/18639 0.113924050632911 0.7630004957768 0.852731624414445 1 GO:0016835 carbon-oxygen lyase activity 9/2783 79/18639 0.113924050632911 0.7630004957768 0.852731624414445 1 GO:0000340 RNA 7-methylguanosine cap binding 1/2783 12/18639 0.0833333333333333 0.558120733021919 0.856456903354897 1 GO:0004300 enoyl-CoA hydratase activity 1/2783 12/18639 0.0833333333333333 0.558120733021919 0.856456903354897 1 GO:0005436 sodium:phosphate symporter activity 1/2783 12/18639 0.0833333333333333 0.558120733021919 0.856456903354897 1 GO:0008179 adenylate cyclase binding 1/2783 12/18639 0.0833333333333333 0.558120733021919 0.856456903354897 1 GO:0010853 cyclase activator activity 1/2783 12/18639 0.0833333333333333 0.558120733021919 0.856456903354897 1 GO:0015269 calcium-activated potassium channel activity 1/2783 12/18639 0.0833333333333333 0.558120733021919 0.856456903354897 1 GO:0034452 dynactin binding 1/2783 12/18639 0.0833333333333333 0.558120733021919 0.856456903354897 1 GO:0036009 protein-glutamine N-methyltransferase activity 1/2783 12/18639 0.0833333333333333 0.558120733021919 0.856456903354897 1 GO:0097371 MDM2/MDM4 family protein binding 1/2783 12/18639 0.0833333333333333 0.558120733021919 0.856456903354897 1 GO:0140829 bicarbonate:monoatomic anion antiporter activity 1/2783 12/18639 0.0833333333333333 0.558120733021919 0.856456903354897 1 GO:0140900 chloride:bicarbonate antiporter activity 1/2783 12/18639 0.0833333333333333 0.558120733021919 0.856456903354897 1 GO:0004867 serine-type endopeptidase inhibitor activity 11/2783 95/18639 0.115789473684211 0.775494071146245 0.857709027431179 1 GO:0005184 neuropeptide hormone activity 3/2783 31/18639 0.0967741935483871 0.64814020608997 0.862097054216618 1 GO:0005452 solute:inorganic anion antiporter activity 3/2783 31/18639 0.0967741935483871 0.64814020608997 0.862097054216618 1 GO:0016879 ligase activity, forming carbon-nitrogen bonds 5/2783 48/18639 0.104166666666667 0.697650916277399 0.863132239793602 1 GO:0004532 RNA exonuclease activity 4/2783 40/18639 0.1 0.669744879626303 0.86763764799685 1 GO:0071855 neuropeptide receptor binding 4/2783 40/18639 0.1 0.669744879626303 0.86763764799685 1 GO:0020037 heme binding 17/2783 142/18639 0.119718309859155 0.801807250256841 0.868595836676392 1 GO:1901681 sulfur compound binding 35/2783 275/18639 0.127272727272727 0.85240257406984 0.869528885136423 1 GO:0043022 ribosome binding 13/2783 112/18639 0.116071428571429 0.777382449566244 0.871524956084672 1 GO:0015103 inorganic anion transmembrane transporter activity 20/2783 165/18639 0.121212121212121 0.811811975304609 0.871927294761285 1 GO:0015106 bicarbonate transmembrane transporter activity 3/2783 32/18639 0.09375 0.627885824649659 0.876322070759604 1 GO:0160041 neuropeptide activity 3/2783 32/18639 0.09375 0.627885824649659 0.876322070759604 1 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 1/2783 13/18639 0.0769230769230769 0.51518836894331 0.877903214514145 1 GO:0005035 death receptor activity 1/2783 13/18639 0.0769230769230769 0.51518836894331 0.877903214514145 1 GO:0008417 fucosyltransferase activity 1/2783 13/18639 0.0769230769230769 0.51518836894331 0.877903214514145 1 GO:0030955 potassium ion binding 1/2783 13/18639 0.0769230769230769 0.51518836894331 0.877903214514145 1 GO:0039706 co-receptor binding 1/2783 13/18639 0.0769230769230769 0.51518836894331 0.877903214514145 1 GO:0046975 histone H3K36 methyltransferase activity 1/2783 13/18639 0.0769230769230769 0.51518836894331 0.877903214514145 1 GO:0051011 microtubule minus-end binding 1/2783 13/18639 0.0769230769230769 0.51518836894331 0.877903214514145 1 GO:0070700 BMP receptor binding 1/2783 13/18639 0.0769230769230769 0.51518836894331 0.877903214514145 1 GO:0097157 pre-mRNA intronic binding 1/2783 13/18639 0.0769230769230769 0.51518836894331 0.877903214514145 1 GO:0140333 glycerophospholipid flippase activity 1/2783 13/18639 0.0769230769230769 0.51518836894331 0.877903214514145 1 GO:0140666 annealing activity 1/2783 13/18639 0.0769230769230769 0.51518836894331 0.877903214514145 1 GO:1901338 catecholamine binding 1/2783 13/18639 0.0769230769230769 0.51518836894331 0.877903214514145 1 GO:0000295 adenine nucleotide transmembrane transporter activity 2/2783 23/18639 0.0869565217391304 0.582386851848959 0.878004364929234 1 GO:0015108 chloride transmembrane transporter activity 14/2783 121/18639 0.115702479338843 0.774911430972582 0.881480547790684 1 GO:0008408 3'-5' exonuclease activity 6/2783 58/18639 0.103448275862069 0.692839530647899 0.882552638582378 1 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 14/2783 122/18639 0.114754098360656 0.768559697931823 0.888460505964575 1 GO:0008135 translation factor activity, RNA binding 9/2783 83/18639 0.108433734939759 0.726229387546593 0.88924923597155 1 GO:0044183 protein folding chaperone 8/2783 75/18639 0.106666666666667 0.714394538268056 0.889316196649122 1 GO:0016500 protein-hormone receptor activity 7/2783 67/18639 0.104477611940299 0.699733456325988 0.890183776183616 1 GO:0070888 E-box binding 6/2783 59/18639 0.101694915254237 0.681096487755562 0.892174418930693 1 GO:0005540 hyaluronic acid binding 2/2783 24/18639 0.0833333333333333 0.558120733021919 0.892620052244242 1 GO:0048027 mRNA 5'-UTR binding 2/2783 24/18639 0.0833333333333333 0.558120733021919 0.892620052244242 1 GO:0140612 DNA damage sensor activity 2/2783 24/18639 0.0833333333333333 0.558120733021919 0.892620052244242 1 GO:0004252 serine-type endopeptidase activity 21/2783 176/18639 0.119318181818182 0.799127413190475 0.893050037551968 1 GO:0003743 translation initiation factor activity 5/2783 51/18639 0.0980392156862745 0.65661262708461 0.895778245446745 1 GO:0005344 oxygen carrier activity 1/2783 14/18639 0.0714285714285714 0.478389199733073 0.896146280873382 1 GO:0008174 mRNA methyltransferase activity 1/2783 14/18639 0.0714285714285714 0.478389199733073 0.896146280873382 1 GO:0008559 ABC-type xenobiotic transporter activity 1/2783 14/18639 0.0714285714285714 0.478389199733073 0.896146280873382 1 GO:0015386 potassium:proton antiporter activity 1/2783 14/18639 0.0714285714285714 0.478389199733073 0.896146280873382 1 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 1/2783 14/18639 0.0714285714285714 0.478389199733073 0.896146280873382 1 GO:0061783 peptidoglycan muralytic activity 1/2783 14/18639 0.0714285714285714 0.478389199733073 0.896146280873382 1 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 1/2783 14/18639 0.0714285714285714 0.478389199733073 0.896146280873382 1 GO:1901612 cardiolipin binding 1/2783 14/18639 0.0714285714285714 0.478389199733073 0.896146280873382 1 GO:0180051 translation factor activity 9/2783 84/18639 0.107142857142857 0.71758379959961 0.897105416787762 1 GO:0051536 iron-sulfur cluster binding 8/2783 76/18639 0.105263157894737 0.70499461013295 0.897529491185657 1 GO:0019825 oxygen binding 3/2783 34/18639 0.0882352941176471 0.590951364376149 0.900914652166057 1 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 6/2783 60/18639 0.1 0.669744879626303 0.901115860042025 1 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 5/2783 52/18639 0.0961538461538462 0.643985461179137 0.905050459623104 1 GO:0051540 metal cluster binding 8/2783 77/18639 0.103896103896104 0.695838835975379 0.905223644784685 1 GO:0000030 mannosyltransferase activity 2/2783 25/18639 0.08 0.535795903701042 0.905592748481965 1 GO:0017056 structural constituent of nuclear pore 2/2783 25/18639 0.08 0.535795903701042 0.905592748481965 1 GO:0140713 histone chaperone activity 19/2783 164/18639 0.115853658536585 0.775923945908521 0.909856070540369 1 GO:0030547 signaling receptor inhibitor activity 4/2783 44/18639 0.0909090909090909 0.608858981478457 0.9112871875588 1 GO:0000175 3'-5'-RNA exonuclease activity 3/2783 35/18639 0.0857142857142857 0.574067039679688 0.911475945919628 1 GO:0034061 DNA polymerase activity 3/2783 35/18639 0.0857142857142857 0.574067039679688 0.911475945919628 1 GO:0000774 adenyl-nucleotide exchange factor activity 1/2783 15/18639 0.0666666666666667 0.446496586417535 0.911664396327308 1 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 1/2783 15/18639 0.0666666666666667 0.446496586417535 0.911664396327308 1 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 1/2783 15/18639 0.0666666666666667 0.446496586417535 0.911664396327308 1 GO:0008242 omega peptidase activity 1/2783 15/18639 0.0666666666666667 0.446496586417535 0.911664396327308 1 GO:0015116 sulfate transmembrane transporter activity 1/2783 15/18639 0.0666666666666667 0.446496586417535 0.911664396327308 1 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 1/2783 15/18639 0.0666666666666667 0.446496586417535 0.911664396327308 1 GO:0034483 heparan sulfate sulfotransferase activity 1/2783 15/18639 0.0666666666666667 0.446496586417535 0.911664396327308 1 GO:0055105 ubiquitin-protein transferase inhibitor activity 1/2783 15/18639 0.0666666666666667 0.446496586417535 0.911664396327308 1 GO:0140161 monocarboxylate:sodium symporter activity 1/2783 15/18639 0.0666666666666667 0.446496586417535 0.911664396327308 1 GO:0141050 histone H3K deacetylase activity 1/2783 15/18639 0.0666666666666667 0.446496586417535 0.911664396327308 1 GO:0141051 histone H4K deacetylase activity 1/2783 15/18639 0.0666666666666667 0.446496586417535 0.911664396327308 1 GO:0016782 transferase activity, transferring sulphur-containing groups 7/2783 70/18639 0.1 0.669744879626303 0.914221110956829 1 GO:0015216 purine nucleotide transmembrane transporter activity 2/2783 26/18639 0.0769230769230769 0.51518836894331 0.917087048221177 1 GO:0120014 phospholipid transfer activity 2/2783 26/18639 0.0769230769230769 0.51518836894331 0.917087048221177 1 GO:0008276 protein methyltransferase activity 10/2783 95/18639 0.105263157894737 0.70499461013295 0.917303027452607 1 GO:0051539 4 iron, 4 sulfur cluster binding 4/2783 45/18639 0.0888888888888889 0.595328781890047 0.919970068508193 1 GO:0140303 intramembrane lipid transporter activity 4/2783 45/18639 0.0888888888888889 0.595328781890047 0.919970068508193 1 GO:0016874 ligase activity 19/2783 167/18639 0.11377245508982 0.761985192389206 0.923997172824024 1 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 1/2783 16/18639 0.0625 0.418590549766439 0.924864459956018 1 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 1/2783 16/18639 0.0625 0.418590549766439 0.924864459956018 1 GO:0008142 oxysterol binding 1/2783 16/18639 0.0625 0.418590549766439 0.924864459956018 1 GO:0008296 3'-5'-DNA exonuclease activity 1/2783 16/18639 0.0625 0.418590549766439 0.924864459956018 1 GO:0015385 sodium:proton antiporter activity 1/2783 16/18639 0.0625 0.418590549766439 0.924864459956018 1 GO:0017070 U6 snRNA binding 1/2783 16/18639 0.0625 0.418590549766439 0.924864459956018 1 GO:0043023 ribosomal large subunit binding 1/2783 16/18639 0.0625 0.418590549766439 0.924864459956018 1 GO:0140328 floppase activity 1/2783 16/18639 0.0625 0.418590549766439 0.924864459956018 1 GO:0046873 metal ion transmembrane transporter activity 57/2783 450/18639 0.126666666666667 0.848343514193317 0.926286385301378 1 GO:0005104 fibroblast growth factor receptor binding 2/2783 27/18639 0.0740740740740741 0.496107318241706 0.92725504175312 1 GO:0008395 steroid hydroxylase activity 2/2783 27/18639 0.0740740740740741 0.496107318241706 0.92725504175312 1 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 2/2783 27/18639 0.0740740740740741 0.496107318241706 0.92725504175312 1 GO:0030280 structural constituent of skin epidermis 3/2783 37/18639 0.0810810810810811 0.543036388886191 0.929583954954754 1 GO:0061749 forked DNA-dependent helicase activity 4/2783 47/18639 0.0851063829787234 0.569995642235151 0.9350822910365 1 GO:1990518 single-stranded 3'-5' DNA helicase activity 4/2783 47/18639 0.0851063829787234 0.569995642235151 0.9350822910365 1 GO:0016887 ATP hydrolysis activity 52/2783 417/18639 0.124700239808153 0.835173470996828 0.93537582442108 1 GO:0140097 catalytic activity, acting on DNA 41/2783 336/18639 0.12202380952381 0.817248216210667 0.935458023458945 1 GO:0004549 tRNA-specific ribonuclease activity 1/2783 17/18639 0.0588235294117647 0.393967576250766 0.936092629850364 1 GO:0009881 photoreceptor activity 1/2783 17/18639 0.0588235294117647 0.393967576250766 0.936092629850364 1 GO:0016018 cyclosporin A binding 1/2783 17/18639 0.0588235294117647 0.393967576250766 0.936092629850364 1 GO:0031489 myosin V binding 1/2783 17/18639 0.0588235294117647 0.393967576250766 0.936092629850364 1 GO:0032183 SUMO binding 1/2783 17/18639 0.0588235294117647 0.393967576250766 0.936092629850364 1 GO:0016866 intramolecular transferase activity 2/2783 28/18639 0.0714285714285714 0.478389199733073 0.936236378548474 1 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 3/2783 38/18639 0.0789473684210526 0.528745957599713 0.937299134118557 1 GO:0003678 DNA helicase activity 7/2783 74/18639 0.0945945945945946 0.633542453700557 0.9391147979209 1 GO:0009378 four-way junction helicase activity 4/2783 48/18639 0.0833333333333333 0.558120733021919 0.941623204785854 1 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 4/2783 48/18639 0.0833333333333333 0.558120733021919 0.941623204785854 1 GO:0036121 double-stranded DNA helicase activity 4/2783 48/18639 0.0833333333333333 0.558120733021919 0.941623204785854 1 GO:0043138 3'-5' DNA helicase activity 4/2783 48/18639 0.0833333333333333 0.558120733021919 0.941623204785854 1 GO:0005254 chloride channel activity 8/2783 83/18639 0.0963855421686747 0.645537233374749 0.941782313890695 1 GO:0000217 DNA secondary structure binding 3/2783 39/18639 0.0769230769230769 0.51518836894331 0.94422580813686 1 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 3/2783 39/18639 0.0769230769230769 0.51518836894331 0.94422580813686 1 GO:0008509 monoatomic anion transmembrane transporter activity 16/2783 149/18639 0.10738255033557 0.71918913248462 0.945547077160225 1 GO:0000400 four-way junction DNA binding 1/2783 18/18639 0.0555555555555556 0.372080488681279 0.945643387616793 1 GO:0003746 translation elongation factor activity 1/2783 18/18639 0.0555555555555556 0.372080488681279 0.945643387616793 1 GO:0008525 phosphatidylcholine transporter activity 1/2783 18/18639 0.0555555555555556 0.372080488681279 0.945643387616793 1 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 1/2783 18/18639 0.0555555555555556 0.372080488681279 0.945643387616793 1 GO:1901611 phosphatidylglycerol binding 1/2783 18/18639 0.0555555555555556 0.372080488681279 0.945643387616793 1 GO:0017116 single-stranded DNA helicase activity 5/2783 58/18639 0.0862068965517241 0.577366275539916 0.946909118298739 1 GO:0140662 ATP-dependent protein folding chaperone 3/2783 40/18639 0.075 0.502308659719727 0.950435658959023 1 GO:0015215 nucleotide transmembrane transporter activity 2/2783 30/18639 0.0666666666666667 0.446496586417535 0.951137595761488 1 GO:0036002 pre-mRNA binding 5/2783 59/18639 0.0847457627118644 0.567580406462968 0.951977146018002 1 GO:0005548 phospholipid transporter activity 6/2783 68/18639 0.0882352941176471 0.590951364376149 0.952282975690148 1 GO:0003756 protein disulfide isomerase activity 1/2783 19/18639 0.0526315789473684 0.352497305066475 0.95376725058132 1 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 1/2783 19/18639 0.0526315789473684 0.352497305066475 0.95376725058132 1 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 1/2783 19/18639 0.0526315789473684 0.352497305066475 0.95376725058132 1 GO:0022821 solute:potassium antiporter activity 1/2783 19/18639 0.0526315789473684 0.352497305066475 0.95376725058132 1 GO:0034987 immunoglobulin receptor binding 1/2783 19/18639 0.0526315789473684 0.352497305066475 0.95376725058132 1 GO:0005253 monoatomic anion channel activity 10/2783 103/18639 0.0970873786407767 0.650237747210002 0.955210434458117 1 GO:0005272 sodium channel activity 4/2783 51/18639 0.0784313725490196 0.525290101667688 0.957797647069692 1 GO:0051082 unfolded protein binding 12/2783 121/18639 0.0991735537190083 0.664209797976498 0.959771036787821 1 GO:0000339 RNA cap binding 1/2783 20/18639 0.05 0.334872439813151 0.960677333375745 1 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 1/2783 20/18639 0.05 0.334872439813151 0.960677333375745 1 GO:0140664 ATP-dependent DNA damage sensor activity 1/2783 20/18639 0.05 0.334872439813151 0.960677333375745 1 GO:0140939 histone H4 methyltransferase activity 1/2783 20/18639 0.05 0.334872439813151 0.960677333375745 1 GO:0016859 cis-trans isomerase activity 3/2783 42/18639 0.0714285714285714 0.478389199733073 0.960966392464418 1 GO:0008094 ATP-dependent activity, acting on DNA 23/2783 210/18639 0.10952380952381 0.733530106257379 0.96216205753624 1 GO:0022884 macromolecule transmembrane transporter activity 2/2783 32/18639 0.0625 0.418590549766439 0.962675406231581 1 GO:0030515 snoRNA binding 2/2783 32/18639 0.0625 0.418590549766439 0.962675406231581 1 GO:0031369 translation initiation factor binding 2/2783 32/18639 0.0625 0.418590549766439 0.962675406231581 1 GO:0015081 sodium ion transmembrane transporter activity 17/2783 164/18639 0.103658536585366 0.694247741076045 0.965773771986906 1 GO:0008146 sulfotransferase activity 4/2783 53/18639 0.0754716981132075 0.505467833680228 0.966160526940425 1 GO:0017046 peptide hormone binding 4/2783 53/18639 0.0754716981132075 0.505467833680228 0.966160526940425 1 GO:0008170 N-methyltransferase activity 9/2783 98/18639 0.0918367346938776 0.615071828228237 0.966360638166765 1 GO:0005248 voltage-gated sodium channel activity 1/2783 21/18639 0.0476190476190476 0.318926133155382 0.96655493051927 1 GO:0009975 cyclase activity 1/2783 21/18639 0.0476190476190476 0.318926133155382 0.96655493051927 1 GO:0070182 DNA polymerase binding 1/2783 21/18639 0.0476190476190476 0.318926133155382 0.96655493051927 1 GO:1904047 S-adenosyl-L-methionine binding 1/2783 21/18639 0.0476190476190476 0.318926133155382 0.96655493051927 1 GO:0042923 neuropeptide binding 2/2783 33/18639 0.0606060606060606 0.405905987652305 0.967413920828687 1 GO:0030020 extracellular matrix structural constituent conferring tensile strength 3/2783 44/18639 0.0681818181818182 0.456644236108843 0.969365666427132 1 GO:0017069 snRNA binding 4/2783 54/18639 0.0740740740740741 0.496107318241706 0.96973706078417 1 GO:0004407 histone deacetylase activity 1/2783 22/18639 0.0454545454545455 0.304429490739228 0.97155426602066 1 GO:0033558 protein lysine deacetylase activity 1/2783 22/18639 0.0454545454545455 0.304429490739228 0.97155426602066 1 GO:0034062 5'-3' RNA polymerase activity 1/2783 22/18639 0.0454545454545455 0.304429490739228 0.97155426602066 1 GO:0097747 RNA polymerase activity 1/2783 22/18639 0.0454545454545455 0.304429490739228 0.97155426602066 1 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 2/2783 34/18639 0.0588235294117647 0.393967576250766 0.971570125120101 1 GO:0019843 rRNA binding 5/2783 65/18639 0.0769230769230769 0.51518836894331 0.974172789696383 1 GO:0004222 metalloendopeptidase activity 10/2783 110/18639 0.0909090909090909 0.608858981478457 0.974785344052999 1 GO:0004022 alcohol dehydrogenase (NAD+) activity 1/2783 23/18639 0.0434782608695652 0.291193425924479 0.975806534252089 1 GO:0008171 O-methyltransferase activity 1/2783 23/18639 0.0434782608695652 0.291193425924479 0.975806534252089 1 GO:0140102 catalytic activity, acting on a rRNA 1/2783 23/18639 0.0434782608695652 0.291193425924479 0.975806534252089 1 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 2/2783 36/18639 0.0555555555555556 0.372080488681279 0.978400943770535 1 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 2/2783 36/18639 0.0555555555555556 0.372080488681279 0.978400943770535 1 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 2/2783 36/18639 0.0555555555555556 0.372080488681279 0.978400943770535 1 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 2/2783 36/18639 0.0555555555555556 0.372080488681279 0.978400943770535 1 GO:0022829 wide pore channel activity 2/2783 37/18639 0.0540540540540541 0.362024259257461 0.98119048598858 1 GO:0008188 neuropeptide receptor activity 3/2783 48/18639 0.0625 0.418590549766439 0.981306630475942 1 GO:0015459 potassium channel regulator activity 4/2783 59/18639 0.0677966101694915 0.454064325170375 0.982890904840131 1 GO:0004497 monooxygenase activity 9/2783 106/18639 0.0849056603773585 0.568651312890257 0.983356025066016 1 GO:0008320 protein transmembrane transporter activity 1/2783 27/18639 0.037037037037037 0.248053659120853 0.987341540831165 1 GO:0005242 inward rectifier potassium channel activity 1/2783 28/18639 0.0357142857142857 0.239194599866537 0.989234324619413 1 GO:0008227 G protein-coupled amine receptor activity 2/2783 41/18639 0.0487804878048781 0.326704819329904 0.989239574993818 1 GO:0008307 structural constituent of muscle 2/2783 42/18639 0.0476190476190476 0.318926133155382 0.990653234120288 1 GO:0005245 voltage-gated calcium channel activity 2/2783 43/18639 0.0465116279069767 0.311509246337815 0.991884817729051 1 GO:0003730 mRNA 3'-UTR binding 26/2783 262/18639 0.099236641221374 0.664632323293277 0.993609227373606 1 GO:0001653 peptide receptor activity 10/2783 128/18639 0.078125 0.523238187208049 0.994989147582977 1 GO:0000049 tRNA binding 5/2783 80/18639 0.0625 0.418590549766439 0.995112320877582 1 GO:0099095 ligand-gated monoatomic anion channel activity 2/2783 47/18639 0.0425531914893617 0.284997821117576 0.99540755288663 1 GO:0008175 tRNA methyltransferase activity 1/2783 34/18639 0.0294117647058824 0.196983788125383 0.995926968987056 1 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 1/2783 34/18639 0.0294117647058824 0.196983788125383 0.995926968987056 1 GO:0005200 structural constituent of cytoskeleton 8/2783 112/18639 0.0714285714285714 0.478389199733073 0.996189347068668 1 GO:0099094 ligand-gated monoatomic cation channel activity 10/2783 136/18639 0.0735294117647059 0.492459470313458 0.997686546982481 1 GO:0008173 RNA methyltransferase activity 3/2783 67/18639 0.0447761194029851 0.299885766996852 0.998427632939738 1 GO:0008528 G protein-coupled peptide receptor activity 8/2783 122/18639 0.0655737704918033 0.439176970246756 0.998666945842085 1 GO:0004812 aminoacyl-tRNA ligase activity 1/2783 41/18639 0.024390243902439 0.163352409664952 0.998690053942089 1 GO:0016875 ligase activity, forming carbon-oxygen bonds 1/2783 41/18639 0.024390243902439 0.163352409664952 0.998690053942089 1 GO:0005261 monoatomic cation channel activity 32/2783 341/18639 0.093841642228739 0.628499593784213 0.999169339530126 1 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 12/2783 167/18639 0.0718562874251497 0.481253805719499 0.999293038587424 1 GO:0005216 monoatomic ion channel activity 43/2783 448/18639 0.0959821428571429 0.642835487141317 0.999719363751623 1 GO:0140098 catalytic activity, acting on RNA 35/2783 387/18639 0.0904392764857881 0.605712423434641 0.999816474605047 1 GO:0008168 methyltransferase activity 14/2783 204/18639 0.0686274509803922 0.459628838959227 0.999879313748487 1 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 1/2783 56/18639 0.0178571428571429 0.119597299933268 0.999884955465679 1 GO:0022832 voltage-gated channel activity 11/2783 175/18639 0.0628571428571429 0.420982495765105 0.999885873498656 1 GO:0015276 ligand-gated monoatomic ion channel activity 12/2783 186/18639 0.0645161290322581 0.432093470726647 0.999897380462976 1 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 2/2783 73/18639 0.0273972602739726 0.183491747842823 0.999898930247191 1 GO:0022834 ligand-gated channel activity 12/2783 188/18639 0.0638297872340425 0.427496731676363 0.999916822081138 1 GO:0005244 voltage-gated monoatomic ion channel activity 10/2783 173/18639 0.0578034682080925 0.387135768570117 0.999953634672033 1 GO:0016741 transferase activity, transferring one-carbon groups 14/2783 215/18639 0.0651162790697674 0.436112944872941 0.999960534428206 1 GO:0022843 voltage-gated monoatomic cation channel activity 7/2783 143/18639 0.048951048951049 0.327847143873015 0.999964818201156 1 GO:0005249 voltage-gated potassium channel activity 3/2783 98/18639 0.0306122448979592 0.205023942742746 0.999979136088583 1 GO:0005267 potassium channel activity 5/2783 124/18639 0.0403225806451613 0.270058419204154 0.999979720993099 1 GO:0015079 potassium ion transmembrane transporter activity 8/2783 160/18639 0.05 0.334872439813151 0.999982665983744 1 GO:0098960 postsynaptic neurotransmitter receptor activity 1/2783 69/18639 0.0144927536231884 0.0970644753081598 0.99998604977764 1 GO:0140101 catalytic activity, acting on a tRNA 5/2783 139/18639 0.0359712230215827 0.240915424326008 0.999997257792001 1 GO:0030594 neurotransmitter receptor activity 2/2783 97/18639 0.0206185567010309 0.138091727758001 0.999997326700898 1 GO:0022836 gated channel activity 20/2783 318/18639 0.0628930817610063 0.421223194733524 0.999999560413555 1 GO:0003735 structural constituent of ribosome 4/2783 175/18639 0.0228571428571429 0.153084543914583 0.999999997597804 1 GO:0045182 translation regulator activity 13/2783 356/18639 0.0365168539325843 0.244569759414099 0.999999999999473 1 GO:0030371 translation repressor activity 8/2783 329/18639 0.0243161094224924 0.162855897781472 0.999999999999998 1 GO:1903231 mRNA base-pairing translational repressor activity 1/2783 298/18639 0.00335570469798658 0.0224746603901444 1 1