category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	28/442	95/9376	6.25215527506549	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/CCL3/CXCL2/IL1B/CXCL3/HLA-DQB1/ITGB2/HLA-DMA/HLA-DQA1/CCL20/HLA-DMB/ATP6V0E1/HLA-DQA2/TNFSF13B/CTSL/ACP5/ATP6V0D1/HLA-DRB5/IL18/CCL2/CD86/ICAM1/ATP6V1D/TNF/CCL5	11.4439452721816
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	35/442	155/9376	4.78995767041308	HLA-DRA/HLA-DRB1/HLA-B/HLA-DPA1/HLA-DPB1/HLA-A/CTSS/HLA-DQB1/MSR1/ITGB2/HLA-DMA/HLA-DQA1/FCGR3A/HLA-DMB/OLR1/NCF2/ATP6V0E1/CD14/HLA-DQA2/CYBA/CTSL/CD36/CYBB/FCGR2A/ATP6V0D1/HLA-DRB5/MARCO/HLA-F/FCGR1A/ATP6V1D/ITGA5/CLEC7A/TUBA1A/CORO1A/NCF4	10.5824200553852
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	24/442	82/9376	6.20858624875842	HLA-DRA/CD74/HLA-DRB1/HLA-B/HLA-DPA1/HLA-DPB1/HLA-A/CTSS/CTSB/HLA-DQB1/LGMN/HLA-DMA/HLA-DQA1/HLA-DMB/HLA-DQA2/CTSL/B2M/HLA-DRB5/CD4/HLA-F/HSPA6/TNF/TAPBPL/IFI30	10.5365698592669
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	22/442	78/9376	5.98306067989326	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/IL1B/HLA-DQB1/ITGB2/HLA-DMA/HLA-DQA1/FCGR3A/HLA-DMB/NFKBIA/NCF2/HLA-DQA2/CYBA/CYBB/FCGR2A/HLA-DRB5/FCGR1A/PTGS2/TNF/NCF4	9.82929806642849
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	24/442	99/9376	5.1424653777595	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/C1QB/C1QA/HLA-DQB1/ITGB2/HLA-DMA/HLA-DQA1/FCGR3A/HLA-DMB/C1QC/C5AR1/HLA-DQA2/FPR3/FCGR2A/HLA-DRB5/ICAM1/FCGR1A/C3AR1/KRT18/KRT14/FPR1	9.21608571159348
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	16/442	44/9376	7.71369806663924	HLA-DRA/HLA-DRB1/HLA-B/HLA-DPA1/HLA-DPB1/HLA-A/IL1B/HLA-DQB1/HLA-DMA/HLA-DQA1/HLA-DMB/HLA-DQA2/HLA-DRB5/CD86/HLA-F/TNF	9.9282928289198
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	16/442	45/9376	7.54228255404726	HLA-DRA/HLA-DRB1/HLA-B/HLA-DPA1/HLA-DPB1/HLA-A/IL1B/HLA-DQB1/HLA-DMA/HLA-DQA1/HLA-DMB/HLA-DQA2/HLA-DRB5/CD86/HLA-F/TNF	9.78464915415879
Human Diseases	Immune disease	hsa05330	Allograft rejection	15/442	39/9376	8.15871910894535	HLA-DRA/HLA-DRB1/HLA-B/HLA-DPA1/HLA-DPB1/HLA-A/HLA-DQB1/HLA-DMA/HLA-DQA1/HLA-DMB/HLA-DQA2/HLA-DRB5/CD86/HLA-F/TNF	9.96409237164253
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	31/442	181/9376	3.63310917227069	HLA-DRA/CD74/HLA-DRB1/CTSD/HLA-DPA1/HLA-DPB1/FCER1G/CTSS/IL1B/HLA-DQB1/ITGB2/HLA-DMA/CALM2/HLA-DQA1/FCGR3A/HLA-DMB/LSP1/CD14/HLA-DQA2/FCGR2A/ATP6V0D1/HLA-DRB5/IL18/ITGAX/FCGR1A/CLEC7A/TNF/SYK/PLK3/CORO1A/TRADD	7.95620721155892
Human Diseases	Immune disease	hsa05310	Asthma	13/442	32/9376	8.61764705882353	HLA-DRA/HLA-DRB1/PRG2/HLA-DPA1/HLA-DPB1/FCER1G/HLA-DQB1/HLA-DMA/HLA-DQA1/HLA-DMB/HLA-DQA2/HLA-DRB5/TNF	9.60070709462414
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	21/442	100/9376	4.45466063348416	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/IL1B/HLA-DQB1/HLA-DMA/HLA-DQA1/CD59/CD44/HLA-DMB/CD14/CD37/HLA-DQA2/CD36/CD9/HLA-DRB5/CD4/FCGR1A/ITGA5/TNF	7.72500590320459
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	31/442	205/9376	3.20776956185851	HLA-DRA/HLA-DRB1/VIM/HLA-B/HLA-DPA1/HLA-DPB1/HLA-A/CDKN1A/HLA-DQB1/HLA-DMA/HLA-DQA1/CD44/HLA-DMB/NFKBIA/HLA-DQA2/GADD45B/B2M/CXCL10/HLA-DRB5/ICAM1/HLA-F/PLCG2/TNFAIP3/DDB2/TNF/SYK/TAPBPL/CCNE2/PSMD7/RB1/TRADD	7.10879718818915
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	28/442	180/9376	3.29974861739568	HLA-DRA/CD74/HLA-DRB1/HLA-B/HLA-DPA1/HLA-DPB1/HLA-A/IL1B/HLA-DQB1/HLA-DMA/HLA-DQA1/HLA-DMB/NFKBIA/HLA-DQA2/B2M/HLA-DRB5/CCL2/SP100/HLA-F/TNFRSF14/ITGA5/BST2/TNF/PILRA/SYK/TAPBPL/CCL5/TRADD	6.92932508538668
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	33/442	238/9376	2.94125251910719	RPL34/RPS15A/RPS4Y1/C1QB/IL1B/C1QA/RPS14/FAU/RPS29/RPS21/RPS25/RPL36A/NFKBIA/C1QC/C5AR1/RPS20/RPL31/RPS27L/CYBB/RPS27/FCGR2A/CXCL10/CCL2/RPS28/CASP1/PLCG2/C3AR1/RPS10/MX2/TNF/F13A1/HBEGF/SYK	6.74712463702223
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	31/442	224/9376	2.93568196509373	HLA-DRA/HLA-DRB1/CDKN2A/HLA-B/HLA-DPA1/HLA-DPB1/HLA-A/CDKN1A/HLA-DQB1/ITGB2/HLA-DMA/HLA-DQA1/HLA-DMB/NFKBIA/ZFP36/TGFBR1/SPI1/HLA-DQA2/B2M/HLA-DRB5/ICAM1/CD4/HLA-F/SLC25A5/MMP7/TNF/NFATC2/CCNE2/CREB5/RB1/KRAS	6.521895051326
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	18/442	88/9376	4.33895516248457	SERPINE2/SERPINE1/C1QB/C1QA/ITGB2/PLAUR/CD59/C1QC/C5AR1/SERPINA1/CLU/A2M/ITGAX/SERPING1/F5/VSIG4/C3AR1/F13A1	6.99946133182173
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	16/442	70/9376	4.8486102133161	HLA-DRA/HLA-DRB1/HLA-B/HLA-DPA1/HLA-DPB1/HLA-A/HLA-DQB1/ITGB2/HLA-DMA/HLA-DQA1/HLA-DMB/HLA-DQA2/HLA-DRB5/CD86/ICAM1/HLA-F	7.18861496673771
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	14/442	54/9376	5.49958102899279	HLA-DRA/HLA-DRB1/HLA-B/HLA-DPA1/HLA-DPB1/HLA-A/HLA-DQB1/HLA-DMA/HLA-DQA1/HLA-DMB/HLA-DQA2/HLA-DRB5/CD86/HLA-F	7.37544462166036
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	23/442	142/9376	3.43585494869671	TYROBP/IL1B/TREM2/FCGR3A/NFKBIA/NCF2/TGFBR1/SPI1/SQSTM1/CYBA/LILRB4/FCGR2A/ACP5/JUNB/PLCG2/FCGR1A/LCP2/JUND/TNF/NFATC2/SYK/FOSB/NCF4	6.5054067964517
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	13/442	50/9376	5.51529411764706	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DQB1/HLA-DMA/HLA-DQA1/HLA-DMB/CXCR4/HLA-DQA2/TNFSF13B/HLA-DRB5/CD86	7.12028111163248
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	34/442	298/9376	2.42023748064017	CSH1/CSH2/CCL3/CXCL2/IL1B/CXCL3/CCL4/CCL20/IL1RN/CXCL16/TGFBR1/CXCR4/CCL18/TNFRSF12A/TNFSF10/TNFSF13B/CXCL10/GDF15/CXCL9/IL18/CCL2/OSM/CD4/TNFRSF14/CSHL1/GH2/TNF/EBI3/CXCR6/TNFRSF10C/TNFRSF1B/IL32/CCL5/INHBA	5.54176124649134
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	18/442	105/9376	3.63645765998707	CXCL2/IL1B/CXCL3/BCL2A1/CCL4/NFKBIA/LY96/UBE2I/CD14/GADD45B/TNFSF13B/ICAM1/PLCG2/TNFAIP3/PTGS2/TNF/SYK/TRADD	6.0426293946772
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	18/442	105/9376	3.63645765998707	FCER1G/IL1B/CALM2/NFKBIA/LSP1/RRAS/CASP1/PLCG2/CLEC7A/PTGS2/TNF/MRAS/NFATC2/SYK/BCL3/IRF1/PLK3/KRAS	6.0426293946772
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	32/442	275/9376	2.46838338132456	MT-ND2/MT-ND3/MT-ND1/MT-ATP6/MT-ND4/MT-ND5/MT-ND4L/MT-CYB/MT-CO2/MT-CO1/MT-CO3/C1QB/IL1B/COX4I1/C1QA/NCF2/C1QC/UQCRQ/CYBA/MT-ATP8/CYBB/UQCRB/HSPA6/PRNP/SLC25A5/TNF/TUBA1A/SOD1/PSMD7/CREB5/CCL5/NCF4	5.49711786906405
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	25/442	187/9376	2.83591840685266	GABARAPL1/CTSB/CXCL2/IL1B/CXCL3/GABARAPL2/TXN/IFI16/NFKBIA/GBP2/GBP3/CYBA/CYBB/CASP4/GABARAP/IL18/CCL2/CASP1/GPSM3/GBP1/TNFAIP3/CARD16/TNF/CCL5/TXNIP	5.64045128103952
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	19/442	119/9376	3.38689684018404	CXCL2/IL1B/CXCL3/CCL20/MMP9/NFKBIA/JUNB/CXCL10/CCL2/ICAM1/TNFAIP3/PTGS2/TNF/TNFRSF1B/CREB5/BCL3/CCL5/IRF1/TRADD	5.82835232644096
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	17/442	100/9376	3.60615384615385	CCL3/CXCL2/CXCL3/CCL4/CCL20/CXCR4/CCL18/TNFSF10/CXCL10/CXCL9/IL18/CCL2/TNFRSF14/TNF/TNFRSF10C/TNFRSF1B/CCL5	5.8276502331557
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	23/442	173/9376	2.82018151858342	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/IL1B/HLA-DQB1/HLA-DMA/HLA-DQA1/HLA-DMB/NFKBIA/TNFSF10/HLA-DQA2/CXCL10/HLA-DRB5/IL18/CCL2/ICAM1/CASP1/SLC25A5/MX2/TNF/CCL5/TRADD	5.37460856331701
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	16/442	94/9376	3.61066718012901	CXCL2/IL1B/CXCL3/CCL20/MMP9/S100A8/NFKBIA/CXCL10/S100A9/CCL2/TNFAIP3/JUND/PTGS2/TNF/FOSB/TRADD	5.65807178404396
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	27/442	227/9376	2.52309286981482	MT-ND2/MT-ND3/MT-ND1/MT-ATP6/MT-ND4/MT-ND5/MT-ND4L/MT-CYB/MT-CO2/MT-CO1/MT-CO3/COX4I1/NFKBIA/NCF2/GSTT1/UQCRQ/CYBA/MT-ATP8/HMOX1/GSTA3/UQCRB/SLC25A5/EPHX2/NFE2L2/PLD1/SOD1/KRAS	5.16685529431432
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	26/442	216/9376	2.55337690631808	CCL3/CXCL2/IL1B/CXCL3/CALM2/MMP9/NFKBIA/OLR1/NCF2/LY96/CD14/TNFSF10/CYBA/CD36/CYBB/IL18/CCL2/ICAM1/CASP1/HSPA6/TNF/NFE2L2/NFATC2/CCL5/NCF4/KRAS	5.1372391297242
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	13/442	66/9376	4.17825311942959	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/IL1B/HLA-DQB1/HLA-DMA/HLA-DQA1/HLA-DMB/HLA-DQA2/HLA-DRB5/IL18/TNF	5.76314316199235
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	25/442	205/9376	2.58691093698267	MT-ND2/MT-ND3/MT-ND1/MT-ATP6/MT-ND4/MT-ND5/MT-ND4L/CTSD/MT-CYB/MT-CO2/MT-CO1/MT-CO3/COX4I1/MMP9/NCF2/TGFBR1/UQCRQ/CYBA/CD36/MT-ATP8/CYBB/PDK4/UQCRB/SLC25A5/NCF4	5.10969450871158
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	14/442	78/9376	3.80740225084116	C1QB/IL1B/C1QA/ITGB2/CALM2/C1QC/LY96/CD14/SERPING1/CASP1/ITGA5/IRF8/TNF/IRF1	5.53771974465925
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	17/442	112/9376	3.21978021978022	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DQB1/HLA-DMA/HLA-DQA1/HLA-DMB/NFKBIA/LY96/HLA-DQA2/BIRC7/HLA-DRB5/HSPA6/ALOX5/TNF/LAMB4	5.2564618174162
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	21/442	160/9376	2.7841628959276	HLA-DRA/HLA-DRB1/HLA-B/HLA-DPA1/HLA-DPB1/HLA-A/HLA-DQB1/ITGB2/HLA-DMA/HLA-DQA1/HLA-DMB/HLA-DQA2/ALCAM/HLA-DRB5/PTPRC/CD86/ICAM1/CD4/ESAM/HLA-F/SDC2	5.06287331534708
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	16/442	109/9376	3.1137863755241	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/IL1B/HLA-DQB1/HLA-DMA/HLA-DQA1/HLA-DMB/NFKBIA/TGFBR1/HLA-DQA2/HLA-DRB5/CD4/EBI3/NFATC2	4.93717544745658
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	23/442	196/9376	2.48924185058639	HLA-B/HLA-A/CDKN1A/CXCL2/CXCL3/CALM2/GNG5/NFKBIA/ZFP36/CLEC2B/RCAN1/CD86/ICAM1/HLA-F/PLCG2/TCF7L1/PTGS2/NFATC2/SYK/RB1/FGF2/TRADD/KRAS	4.68646875735434
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	18/442	138/9376	2.76686995868582	MT-ND2/MT-ND3/MT-ND1/MT-ATP6/MT-ND4/MT-ND5/MT-ND4L/MT-CYB/MT-CO2/MT-CO1/MT-CO3/COX4I1/ATP6V0E1/UQCRQ/MT-ATP8/ATP6V0D1/UQCRB/ATP6V1D	4.65081377102608
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	14/442	93/9376	3.19330511360872	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DQB1/HLA-DMA/HLA-DQA1/HLA-DMB/NFKBIA/HLA-DQA2/HLA-DRB5/CD4/NFATC2/NOTCH2	4.7279203231175
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	18/442	142/9376	2.6889299598496	DUSP1/IL1B/CALM2/TXN/MMP9/NCF2/GSTT1/SQSTM1/CYBA/CTSL/GSTP1/HMOX1/GSTA3/CCL2/ICAM1/TNF/NFE2L2/SDC2	4.51060373911636
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	18/442	143/9376	2.67012625383666	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/C1QB/C1QA/HLA-DQB1/HLA-DMA/HLA-DQA1/FCGR3A/HLA-DMB/C1QC/HLA-DQA2/FCGR2A/HLA-DRB5/CD86/FCGR1A/TNF	4.47630533612993
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	10/442	56/9376	3.7879767291532	CXCL2/IL1B/CXCL3/ITGB2/NFKBIA/CD14/IL18/CASP1/HSPA6/TNF	4.65424242491077
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	17/442	144/9376	2.5042735042735	CXCL2/C1QB/IL1B/C1QA/CXCL3/ACADVL/NFKBIA/C1QC/LY96/C5AR1/CD14/LPIN2/C3AR1/TCF7L1/TNF/PRKAG2/TRADD	4.04607522559432
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	23/442	227/9376	2.14930133354596	CDKN2A/HLA-B/CCL3/HLA-A/CDKN1A/IL1B/CALM2/CCL4/GNG5/NFKBIA/CXCR4/B2M/CCL2/HLA-F/PTGS2/TNF/NFATC2/TAPBPL/CREB5/RB1/CCL5/TRADD/KRAS	3.89882573655304
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	22/442	214/9376	2.18074174313866	HLA-B/HLA-A/CALM2/GNG5/NFKBIA/CXCR4/APOBEC3B/B2M/APOBEC3C/CD4/HLA-F/PLCG2/AP1S2/SAMHD1/BST2/TNF/APOBEC3H/NFATC2/TNFRSF1B/TAPBPL/TRADD/KRAS	3.88633701517274
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	9/442	50/9376	3.81828054298642	IL1B/ITGB2/CD36/IL18/CCL2/ICAM1/TNF/CD81/SDC2	4.44421762894253
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	16/442	133/9376	2.55190011227163	TYROBP/HLA-B/FCER1G/HLA-A/ITGB2/FCGR3A/TNFSF10/CD48/HCST/ICAM1/PLCG2/LCP2/TNF/NFATC2/SYK/KRAS	4.00919248216411
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	23/442	232/9376	2.10298018411609	FN1/TMSB4X/GSN/RGCC/ITGB2/CXCR4/ITGB6/ARPC2/MYL12A/IQGAP2/SCIN/ITGAX/BAIAP2/RRAS/NCKAP1L/MYH10/ITGA5/MRAS/PIP5K1B/MYL12B/FGF2/ARPC5/KRAS	3.78370607814776
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	24/442	248/9376	2.05283900160561	S100A10/ANXA2/DYNLT1/IL1B/TXN/NFKBIA/LY96/CD14/ARPC2/DYNLRB1/MYL12A/TNFSF10/CASP4/IL18/PTPRC/RRAS/CASP1/NCKAP1L/TCF7L1/TNF/TUBA1A/MYL12B/ARPC5/TRADD	3.73743620365312
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	8/442	42/9376	4.04050851109675	FTL/SLC40A1/GPX4/FTH1/CYBB/HMOX1/LPCAT3/PRNP	4.39248987585436
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	13/442	98/9376	2.81392557022809	GSN/FCGR3A/MARCKS/ARPC2/SCIN/FCGR2A/PTPRC/PLCG2/FCGR1A/PIP5K1B/PLD1/SYK/ARPC5	4.0149405177689
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	16/442	137/9376	2.47739207979654	CTSD/CTSS/CTSB/BCL2A1/PMAIP1/NFKBIA/TNFSF10/CTSZ/GADD45B/CTSL/NOL3/BBC3/TNF/TUBA1A/TRADD/KRAS	3.87451516695539
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	16/442	138/9376	2.45943996327628	FN1/IL1B/NFKBIA/ARPC2/FCGR2A/IL18/CCL2/BAIAP2/CD4/CASP1/LCP2/ITGA5/TNF/PIP5K1B/NFATC2/ARPC5	3.8415863294431
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	17/442	157/9376	2.296913277805	CDKN2A/HLA-B/HLA-A/CDKN1A/SERPINE1/CALM2/TGFBR1/SQSTM1/GADD45B/RRAS/HLA-F/SLC25A5/MRAS/NFATC2/CCNE2/RB1/KRAS	3.644959054974
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	23/442	250/9376	1.95156561085973	CTSD/VAMP8/LAPTM5/CTSS/HEXB/CTSB/CD68/LGMN/CLTB/ATP6V0E1/ASAH1/CTSZ/CTSL/SLC15A3/ACP5/ATP6V0D1/LIPA/ATP6V1D/SLC11A1/AP1S2/BLOC1S2/PSAP/ARSG	3.39189429445453
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	24/442	268/9376	1.89964206118728	MT-ND2/MT-ND3/MT-ND1/MT-ATP6/MT-ND4/MT-ND5/MT-ND4L/MT-CYB/MT-CO2/MT-CO1/MT-CO3/DUSP1/COX4I1/CALM2/TXN/UQCRQ/MT-ATP8/UBE2L6/UQCRB/SLC25A5/NFE2L2/TUBA1A/SOD1/PSMD7	3.32352872549684
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	19/442	195/9376	2.06687550759949	ITGB2/FCGR3A/NCF2/C5AR1/CYBA/CYBB/FPR3/FCGR2A/CASP4/CASP1/PLCG2/FCGR1A/SLC25A5/AQP9/CLEC7A/SYK/HMGB1/FPR1/NCF4	3.34857365338545
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	12/442	103/9376	2.47137899222422	CCL3/SERPINE1/C1QB/IL1B/C1QA/NFKBIA/PPP2R2B/TGFBR1/C1QC/CCL2/TNF/CCL5	3.3396951996165
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	12/442	109/9376	2.33533978164307	SPP1/CCL3/IL1B/CCL4/NFKBIA/LY96/CD14/CXCL10/CXCL9/CD86/TNF/CCL5	3.11895604034517
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	10/442	83/9376	2.55574333533228	IL1B/CCL4/TREX1/IFI16/NFKBIA/CXCL10/IL18/CASP1/SAMHD1/CCL5	3.1664513921018
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	9/442	71/9376	2.6889299598496	CXCL2/CXCL3/NFKBIA/ATP6V0E1/ATP6V0D1/PLCG2/ATP6V1D/HBEGF/CCL5	3.17728684124353
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	9/442	73/9376	2.61526064588111	CXCR4/APOBEC3B/APOBEC3C/CD4/SAMHD1/MX2/BST2/APOBEC3H/ELL2	3.08152950569756
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	10/442	87/9376	2.43823789462735	MT-CYB/MT-CO2/MT-CO1/MT-CO3/COX4I1/UQCRQ/TNNC1/UQCRB/ATP1B1/CACNA2D3	2.9976413510582
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	10/442	87/9376	2.43823789462735	CDKN1A/PMAIP1/TGFBR1/EREG/GADD45B/DDB2/BBC3/TCF7L1/RALGDS/KRAS	2.9976413510582
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	20/442	235/9376	1.8053335900645	MT-ND2/MT-ND3/MT-ND1/MT-ATP6/MT-ND4/MT-ND5/MT-ND4L/MT-CYB/MT-CO2/MT-CO1/MT-CO3/COX4I1/MGLL/UQCRQ/MT-ATP8/UQCRB/NPPB/PRKAG2/CREB5/KRAS	2.78090843343542
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	11/442	101/9376	2.31029075758255	FN1/SERPINE1/IL1B/TGFBR1/PIM1/CYBB/CCL2/ICAM1/PLCG2/TNF/KRAS	2.94472812431842
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	26/442	333/9376	1.65624447977389	SPP1/FN1/HLA-B/HLA-A/CDKN1A/PPP2R2B/ATP6V0E1/ITGB6/ATP6V0D1/HLA-F/ATP6V1D/HES2/MX2/ITGA5/TCF7L1/PTGS2/TNF/NOTCH2/CCNE2/CREB5/RB1/LAMB4/IRF1/HES4/TRADD/KRAS	2.71209759350758
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	18/442	205/9376	1.86257587462752	CDKN2A/HLA-B/HLA-A/GSN/CDKN1A/PMAIP1/NFKBIA/SCIN/YWHAH/ATP6V0D1/SP100/HLA-F/SYK/CCNE2/CREB5/RB1/TRADD/KRAS	2.77740804932109
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	12/442	116/9376	2.19441410516461	ITGB2/MMP9/NCF2/CXCR4/MYL12A/CYBA/CYBB/ICAM1/ESAM/PLCG2/MYL12B/NCF4	2.87906999565369
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	9/442	75/9376	2.54552036199095	CDKN2A/CDKN1A/SERPINE1/PMAIP1/GADD45B/SESN1/DDB2/BBC3/CCNE2	2.98892033335834
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	17/442	193/9376	1.8684734954165	CCL3/CXCL2/CXCL3/CCL4/CCL20/GNG5/NFKBIA/CXCL16/CXCR4/CCL18/CXCL10/CXCL9/CCL2/PLCG2/CXCR6/CCL5/KRAS	2.71154446198791
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	9/442	77/9376	2.47940294999119	CDKN2A/CDKN1A/TGFBR1/GADD45B/DDB2/PLD1/RB1/RALGDS/KRAS	2.89926236402445
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	6/442	41/9376	3.10429312437921	CDKN2A/CDKN1A/MMP9/HBEGF/RB1/KRAS	3.00341124308287
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	10/442	93/9376	2.28093222400623	FN1/CDKN1A/NFKBIA/GADD45B/BIRC7/DDB2/PTGS2/CCNE2/RB1/LAMB4	2.76119608568767
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	5/442	30/9376	3.53544494720965	IL1B/TYMS/GGH/TNF/FOLR2	3.09368237319225
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	15/442	168/9376	1.8939883645766	FTL/IL1B/FTH1/SQSTM1/TNFSF10/GLUL/CYBB/CASP1/TNFAIP3/SLC25A5/TNF/CHMP1B/CHMP5/HMGB1/TRADD	2.60062450676425
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	15/442	170/9376	1.87170614852276	CDKN2A/IGF2/CDKN1A/GSTT1/TGFBR1/GADD45B/GSTP1/HMOX1/GSTA3/PLCG2/DDB2/TCF7L1/NFE2L2/RB1/KRAS	2.5511317247306
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	8/442	69/9376	2.45943996327628	FCER1G/ALOX5AP/PLCG2/ALOX5/LCP2/TNF/SYK/KRAS	2.70632357926723
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	17/442	204/9376	1.76772247360483	FN1/TIMP3/IGF2/CDKN1A/PLAUR/MMP9/CD44/CTSL/RRAS/PLCG2/ITGA5/TNF/MRAS/HBEGF/SDC2/FGF2/KRAS	2.4658185388114
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	23/442	308/9376	1.5840629958277	MT-ND2/MT-ND3/MT-ND1/MT-ATP6/MT-ND4/MT-ND5/MT-ND4L/MT-CYB/MT-CO2/MT-CO1/MT-CO3/COX4I1/CLTB/UQCRQ/MT-ATP8/WIPI1/UQCRB/SLC25A5/BBC3/TUBA1A/SOD1/PSMD7/CREB5	2.31821169836046
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	12/442	133/9376	1.91392508420372	GABARAPL1/CDKN1A/GABARAPL2/TGFBR1/FBXO32/TNFSF10/GADD45B/HOMER3/GABARAP/PRKAG2/PLK3/KRAS	2.36104214947659
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	10/442	103/9376	2.05948249352019	FN1/CXCL2/IL1B/CXCL3/ITGB2/CD14/PRDX1/HSPB1/TNF/LAMB4	2.40478395871231
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	8/442	76/9376	2.23291259823768	DBI/OLR1/LPL/CYP27A1/CD36/PLIN2/GK/ACADL	2.40033253088692
Human Diseases	Cancer: specific types	hsa05214	Glioma	8/442	76/9376	2.23291259823768	CDKN2A/CDKN1A/CALM2/GADD45B/PLCG2/DDB2/RB1/KRAS	2.40033253088692
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	27/442	388/9376	1.47613938517516	APOE/MT-ND2/MT-ND3/MT-ND1/MT-ATP6/MT-ND4/MT-ND5/MT-ND4L/MT-CYB/MT-CO2/MT-CO1/MT-CO3/IL1B/COX4I1/CALM2/UQCRQ/LPL/MT-ATP8/CYBB/WIPI1/UQCRB/SLC25A5/PTGS2/TNF/TUBA1A/PSMD7/KRAS	2.13055248143543
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	9/442	91/9376	2.09795634230023	NFKBIA/LILRB4/DAPP1/PLCG2/PIK3AP1/NFATC2/SYK/CD81/KRAS	2.34093099897517
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	10/442	106/9376	2.00119525313754	CDKN1A/MMP9/NFKBIA/GSTP1/TCF7L1/FOLR2/CCNE2/CREB5/RB1/KRAS	2.30571511319588
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	8/442	77/9376	2.2039137333255	CDKN2A/CDKN1A/NFKBIA/TGFBR1/GADD45B/DDB2/RB1/KRAS	2.35937191864027
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	14/442	169/9376	1.75726257731131	CTSD/GABARAPL1/VAMP8/CTSB/GABARAPL2/SQSTM1/CTSL/WIPI1/GABARAP/RRAS/OPTN/MRAS/HMGB1/KRAS	2.20955377040824
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	5/442	37/9376	2.86657698422404	IL1B/IL18/ICAM1/APOL1/TNF	2.5302904689793
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	5/442	37/9376	2.86657698422404	CDKN1A/GADD45B/DDB2/TCF7L1/KRAS	2.5302904689793
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	32/442	480/9376	1.41417797888386	MT-ND2/MT-ND3/MT-ND1/MT-ATP6/MT-ND4/MT-ND5/MT-ND4L/MT-CYB/MT-CO2/MT-CO1/MT-CO3/IL1B/COX4I1/CALM2/UQCRQ/SQSTM1/MT-ATP8/CYBB/WIPI1/UBE2L6/UQCRB/PRNP/SLC25A5/OPTN/PTGS2/TNF/TUBA1A/SOD1/TNFRSF1B/PSMD7/ATXN1/KRAS	2.07197272842986
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	19/442	253/9376	1.59304633984941	IL1B/CD44/NFKBIA/CD14/ARPC2/MYL12A/SQSTM1/CASP4/WIPI1/IL18/CASP1/PLCG2/ITGA5/CAST/TNF/MYL12B/CCL5/ARPC5/TRADD	2.12693320731194
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	6/442	52/9376	2.44761573268361	APOE/APOC1/LPL/CYP27A1/CD36/LIPA	2.3282393903263
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	7/442	68/9376	2.18365717327655	BCL2A1/SPI1/CD14/PIM1/FCGR1A/TCF7L1/KRAS	2.17884332431837
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	18/442	250/9376	1.52731221719457	HLA-B/HLA-A/CLTB/TGFBR1/CXCR4/SH3KBP1/ARPC2/HLA-F/NEDD4L/SH3GLB2/HSPA6/PIP5K1B/CHMP1B/PLD1/FOLR2/DAB2/CHMP5/ARPC5	1.8796258297759
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	15/442	200/9376	1.59095022624434	IL1B/NFKBIA/ARPC2/TNFSF10/FCGR2A/CASP4/IL18/BAIAP2/CASP1/NCKAP1L/MYH10/TNF/TUBA1A/ARPC5/TRADD	1.87894036949975
Human Diseases	Cancer: specific types	hsa05218	Melanoma	7/442	73/9376	2.03409161346309	CDKN2A/CDKN1A/GADD45B/DDB2/RB1/FGF2/KRAS	1.97279852425467
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	7/442	73/9376	2.03409161346309	CDKN2A/CDKN1A/GADD45B/PLCG2/DDB2/RB1/KRAS	1.97279852425467
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	8/442	89/9376	1.90675682546139	SPP1/FN1/CD44/ITGB6/CD36/ITGA5/NPNT/LAMB4	1.91170956324668
NA	NA	hsa04518	Integrin signaling	12/442	154/9376	1.65293529999412	SPP1/FN1/ITGB2/ITGB6/FBN1/FERMT3/ITGAX/ICAM1/PARVG/ITGA5/NPNT/LAMB4	1.81715406110153
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	4/442	32/9376	2.65158371040724	GABARAPL1/GABARAPL2/WIPI1/GABARAP	2.08153138671685
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	7/442	75/9376	1.97984917043741	CDKN2A/CDKN1A/PMAIP1/GSTT1/GSTP1/GSTA3/BBC3	1.89495472280411
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	24/442	368/9376	1.38343497934291	MT-ND2/MT-ND3/MT-ND1/MT-ATP6/MT-ND4/MT-ND5/MT-ND4L/MT-CYB/MT-CO2/MT-CO1/MT-CO3/COX4I1/UQCRQ/SQSTM1/MT-ATP8/WIPI1/CASP1/UQCRB/OPTN/TNF/TUBA1A/SOD1/TNFRSF1B/PSMD7	1.66907268115467
Organismal Systems	Digestive system	hsa04978	Mineral absorption	6/442	61/9376	2.08649209999258	MT2A/FTL/SLC40A1/FTH1/HMOX1/ATP1B1	1.89353727834234
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	12/442	157/9376	1.62135054903882	C1QB/C1QA/DUSP2/C1QC/CD36/LIPA/HAVCR2/CASP1/ALOX5/PTGS2/NFATC2/GAS6	1.74629819031944
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	12/442	163/9376	1.56166893373678	CDKN1A/PCNA/MMP9/NFKBIA/TGFBR1/DDB2/TNF/NFATC2/CCNE2/CREB5/RB1/KRAS	1.60896823027956
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	16/442	233/9376	1.45666401258423	FN1/VIM/PDLIM1/CSRP2/ITGB6/FBN1/TNNC1/MYH10/ATP1B1/ITGA5/ZYX/ACTG2/FMNL2/FMNL1/BGN/SDC2	1.57001639581265
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	7/442	82/9376	1.81083765588787	GSTT1/GSTP1/GSTA3/DUT/UPP1/TK2/NME4	1.64026228956529
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	8/442	99/9376	1.71415512591983	CDKN2A/CDKN1A/MMP9/BIK/HBEGF/NOTCH2/RB1/KRAS	1.5888400388782
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	7/442	83/9376	1.7890203347326	CROT/PRDX5/PRDX1/ECH1/EPHX2/PXMP2/SOD1	1.60591691480847
Genetic Information Processing	Translation	hsa03010	Ribosome	15/442	222/9376	1.43328849211202	RPL34/RPS15A/RPS4Y1/RPS14/FAU/RPS29/RPS21/RPS25/RPL36A/RPS20/RPL31/RPS27L/RPS27/RPS28/RPS10	1.45318861446972
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	12/442	170/9376	1.49736491881821	PCNA/MYL6/PPP2R2B/ARPC2/MYL12A/NEDD4L/SYNPO/MYH10/PRKAG2/TUBA1A/MYL12B/ARPC5	1.4555861804066
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	6/442	70/9376	1.81822882999354	NFKBIA/CD36/TNF/PRKAG2/TNFRSF1B/TRADD	1.52832624960472
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	19/442	300/9376	1.34346907993967	IGF2/STMN1/DUSP1/IL1B/DUSP2/TGFBR1/CD14/EREG/GADD45B/HSPB1/RRAS/HSPA6/JUND/TNF/MRAS/FGF2/CACNA2D3/TRADD/KRAS	1.34485304085241
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	11/442	156/9376	1.49576516997331	CDKN1A/NFKBIA/PPP2R2B/YWHAH/CXCL10/MX2/TNF/CD81/RB1/TRADD/KRAS	1.38882219865141
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	8/442	105/9376	1.6162034044387	GABARAPL1/GABARAPL2/SQSTM1/GABARAP/RRAS/OPTN/MRAS/KRAS	1.41230745377481
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	22/442	362/9376	1.28916777080573	SPP1/FN1/CSH1/CSH2/IGF2/CDKN1A/GNG5/PPP2R2B/ITGB6/EREG/YWHAH/OSM/CSHL1/PIK3AP1/ITGA5/GH2/SYK/CCNE2/CREB5/LAMB4/FGF2/KRAS	1.24801324428844
Organismal Systems	Immune system	hsa04611	Platelet activation	9/442	126/9376	1.51519069166128	FCER1G/VAMP8/MYL12A/FCGR2A/FERMT3/PLCG2/LCP2/SYK/MYL12B	1.29495957952424
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	3/442	28/9376	2.27278603749192	ATP6V0E1/ATP6V0D1/ATP6V1D	1.50019897727352
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	5/442	59/9376	1.79768387146254	TYMS/DUT/UPP1/TK2/NME4	1.36707571327905
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	5/442	59/9376	1.79768387146254	CDKN1A/GADD45B/DDB2/TCF7L1/KRAS	1.36707571327905
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	8/442	110/9376	1.54273961332785	HAMP/TGFBR1/EMP3/FBN1/SKIL/TNF/NOG/INHBA	1.27354857533048
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	5/442	60/9376	1.76772247360483	HSPB1/PLCG2/PTGS2/NFATC2/KRAS	1.32690227286948
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	6/442	78/9376	1.63174382178907	FN1/CLTB/ARPC2/ELMO3/ITGA5/ARPC5	1.24614142289001
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	10/442	149/9376	1.42366910625892	FCER1G/RRAS/PLCG2/DGKH/MRAS/PIP5K1B/PLD1/SYK/RALGDS/KRAS	1.15948055393002
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	4/442	46/9376	1.84457997245721	FTL/FTH1/HMOX1/BLVRA	1.27718165410546
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	4/442	46/9376	1.84457997245721	PSMB9/PSMB8/PSMB10/PSMD7	1.27718165410546
NA	NA	hsa04517	IgSF CAM signaling	18/442	299/9376	1.27701690400884	MYL6/ITGB2/ARPC2/MYL12A/CD84/CD48/CD86/ITGAX/ICAM1/BAIAP2/ESAM/PLCG2/MYH10/LCP2/ITGA5/TUBA1A/MYL12B/ARPC5	1.08279064878689
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	5/442	63/9376	1.68354521295698	HPGD/GPX4/ALOX5/EPHX2/PTGS2	1.21078356766023
NA	NA	hsa04981	Folate transport and metabolism	3/442	31/9376	2.05283900160561	TYMS/SLCO2B1/FOLR2	1.30595122631177
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/442	17/9376	2.49560819803034	GLUL/CA8	1.37278135782968
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	3/442	32/9376	1.98868778280543	PMAIP1/BIRC7/BBC3	1.24606741917159
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	10/442	154/9376	1.37744608332844	CDKN1A/MYL6/CALM2/RGS2/RCAN1/PTGS2/PRKAG2/NFATC2/CACNA2D3/KRAS	1.05045275262849
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	5/442	65/9376	1.63174382178907	MGLL/LPL/LPIN2/DGKH/GK	1.13677186730438
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	10/442	157/9376	1.35112545753235	MT-CYB/MT-CO2/MT-CO1/MT-CO3/IL1B/COX4I1/UQCRQ/UQCRB/TNF/PRKAG2	0.986833844457615
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	9/442	139/9376	1.37348220970735	CTSD/CALM2/MMP9/HSPA6/KRT18/HBEGF/CREB5/KRT14/KRAS	0.986701178160838
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	6/442	85/9376	1.49736491881821	TYMS/DUT/UPP1/TK2/GMPR/NME4	1.02453590066081
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	9/442	140/9376	1.36367162249515	SPP1/SERPINE1/CALM2/GNG5/TGFBR1/RRAS/PRKAG2/MRAS/KRAS	0.964284683680014
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	8/442	122/9376	1.39099473332839	NFKBIA/PPP2R2B/PTPRC/CD4/LCP2/TNF/NFATC2/KRAS	0.966851719819766
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	8/442	122/9376	1.39099473332839	CSH1/CSH2/JUNB/PLCG2/CSHL1/GH2/CREB5/KRAS	0.966851719819766
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	4/442	51/9376	1.6637387986869	ATP6V0E1/ATP6V0D1/PLCG2/ATP6V1D	1.05713796901417
NA	NA	hsa04382	Cornified envelope formation	13/442	217/9376	1.27080509623204	S100A10/KRT8/KRT7/S100A8/PPP2R2B/S100A11/COL17A1/DST/S100A6/S100A9/EPHX2/KRT18/KRT14	0.897710839651314
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	5/442	70/9376	1.51519069166128	GSTT1/GSTP1/GSTA3/SULT1A1/PTGS2	0.962297377891422
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	8/442	125/9376	1.35761085972851	CTSD/FCER1G/PPP2R2B/ASAH1/TNF/PLD1/TRADD/KRAS	0.895251718967262
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	12/442	201/9376	1.26642804079152	HPGD/CDKN1A/BCL2A1/MMP9/NUPR1/SPI1/CD14/GADD45B/CD86/FCGR1A/NR4A3/DDB2	0.849275747427787
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/442	20/9376	2.12126696832579	CYB5R1/NPL	1.1164845519966
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	4/442	54/9376	1.57130886542651	SDS/IL4I1/SDSL/CDO1	0.936455388105336
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	18/442	323/9376	1.182130199067	TIMP3/VIM/CDKN2A/STMN1/CDKN1A/MMP9/MARCKS/CD44/UBE2I/PIM1/ZEB2/HMOX1/PLCG2/ITGA5/PTGS2/NOTCH2/CCNE2/KRAS	0.740901991361849
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	3/442	38/9376	1.67468444867826	NEDD4L/ATP1B1/KRAS	0.926913830235845
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	9/442	149/9376	1.28130219563303	MT-ND2/MT-ND3/MT-ND1/MT-ND4/MT-ND5/MT-ND4L/MGLL/GNG5/PTGS2	0.76985652433903
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	9/442	150/9376	1.27276018099547	CDKN1A/TGFBR1/GADD45B/DDB2/TCF7L1/CCNE2/RB1/FGF2/KRAS	0.749020446628501
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	2/442	23/9376	1.84457997245721	PCNA/RPA3	0.901992711821272
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	7/442	115/9376	1.29120598072005	CDKN1A/NR4A2/MAFB/JUND/HBEGF/PLD1/CREB5	0.698866248777268
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	4/442	59/9376	1.43814709717003	GPX4/GSTT1/GSTP1/GSTA3	0.750899293333643
Human Diseases	Infectious disease: viral	hsa05162	Measles	8/442	136/9376	1.24780409901517	IL1B/NFKBIA/HSPA6/TNFAIP3/MX2/BBC3/CCNE2/TRADD	0.647464189813861
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	5/442	79/9376	1.34257403058594	CLTB/ATP6V0E1/ATP6V0D1/ATP6V1D/SLC6A2	0.680096228426156
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	6/442	99/9376	1.28561634443987	ITGB6/TNNC1/ITGA5/TNF/PRKAG2/CACNA2D3	0.635434329788793
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	9/442	158/9376	1.20831662752735	CDKN2A/CDKN1A/PCNA/GADD45B/YWHAH/SMC1B/TFDP2/CCNE2/RB1	0.587364813793925
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	3/442	43/9376	1.47995369883195	ACADVL/ECI1/ACADL	0.701611561053442
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	4/442	62/9376	1.36855933440374	HSPA6/PRKAG2/SOD1/KRAS	0.647603133833821
NA	NA	hsa04081	Hormone signaling	12/442	219/9376	1.16233806483605	CSH1/CSH2/IGF2/SLC40A1/GNG5/HAMP/CRH/NPPB/CSHL1/GH2/ADRB1/DIO2	0.540679139273045
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	3/442	44/9376	1.44631838749486	STX4/CREB5/ARHGDIB	0.660020692321425
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	4/442	63/9376	1.34683617036558	CDKN1A/GADD45B/DDB2/TCF7L1	0.614361022195152
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	11/442	203/9376	1.14945500746718	SPP1/FN1/ITGB6/MYL12A/PARVG/EMP2/ITGA5/ZYX/PIP5K1B/MYL12B/LAMB4	0.478824751115372
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	10/442	184/9376	1.15286248278576	CXCR4/MYL12A/RRAS/PLCG2/PLXNC1/NTN4/NFATC2/DPYSL2/MYL12B/KRAS	0.465777613721811
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	6/442	105/9376	1.21215255332902	ITGB6/TNNC1/ITGA5/TNF/ADRB1/CACNA2D3	0.486243065594336
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	5/442	86/9376	1.23329474902662	CDKN1A/EREG/PLCG2/HBEGF/KRAS	0.483415010210393
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	9/442	166/9376	1.15008450089953	CALM2/RGS2/CNGB1/NPPB/SLC25A5/ATP1B1/NFATC2/ADRB1/CREB5	0.433944185011695
NA	NA	hsa03272	Virion - Hepatitis viruses	3/442	48/9376	1.32579185520362	CD9/CHMP1B/CD81	0.503315577053462
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	8/442	148/9376	1.14663079368962	CDKN1A/GADD45B/DDB2/TCF7L1/NOTCH2/RB1/FGF2/KRAS	0.39992269366212
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/442	29/9376	1.46294273677641	CALM2/CNGB1	0.555346387493138
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	6/442	109/9376	1.16766989082154	NFKBIA/CD36/TNF/PRKAG2/PPP1R3D/CREB5	0.391626929678059
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	5/442	89/9376	1.19172301591337	GABARAPL1/GABARAPL2/GNG5/GLUL/GABARAP	0.404208397140636
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	6/442	110/9376	1.15705470999589	CDKN1A/SERPINE1/CYBB/HMOX1/PLCG2/PFKFB3	0.368531791769879
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	2/442	31/9376	1.36855933440374	GLUL/ACSS1	0.457164404053405
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/442	51/9376	1.24780409901517	PLA2G7/PLD1/PLD3	0.394678030671912
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	4/442	72/9376	1.17848164906988	NFKBIA/CXCL10/TNF/TRADD	0.338141726752047
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	3/442	52/9376	1.2238078663418	HSD17B1/ALOX5/PTGS2	0.359956222163936
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	5/442	93/9376	1.14046611200311	TGFBR1/MYL12A/BAIAP2/TCF7L1/MYL12B	0.302790788900379
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	2/442	33/9376	1.28561634443987	VAMP8/STX4	0.365570085827583
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	3/442	55/9376	1.15705470999589	HEXB/ASAH1/PSAP	0.259821361844345
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	5/442	98/9376	1.08227906547234	CALM2/PLCG2/DGKH/PIP5K1B/INPP1	0.182116377403253
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/442	35/9376	1.21215255332902	FBP1/PFKFB3	0.279678703660557
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	5/442	99/9376	1.07134695369989	DGKH/PIP5K1B/PLD1/RALGDS/KRAS	0.158731475244088
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	4/442	78/9376	1.08782921452605	ISYNA1/PLCG2/PIP5K1B/INPP1	0.173246842447702
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	2/442	36/9376	1.17848164906988	GALNT18/GALNT11	0.238641066368998
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	2/442	36/9376	1.17848164906988	PCNA/RPA3	0.238641066368998
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/442	15/9376	1.41417797888386	HEXB	0.357063378736471
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	6/442	122/9376	1.04324604999629	PPP2R2B/FBP1/CD36/PRKAG2/CREB5/PFKFB3	0.106938826153467
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	6/442	122/9376	1.04324604999629	RCAN1/PLCG2/ATP1B1/DIO2/NOTCH2/KRAS	0.106938826153467
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	4/442	80/9376	1.0606334841629	PLCG2/GAS6/FGF2/KRAS	0.121138797832189
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/442	37/9376	1.14663079368962	GLUL/IL4I1	0.198769460283442
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	3/442	59/9376	1.07861032287752	MGLL/PTGS2/ADRB1	0.134722873388235
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/442	16/9376	1.32579185520362	IL4I1	0.290092224623315
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/442	16/9376	1.32579185520362	HEXB	0.290092224623315
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	2/442	38/9376	1.11645629911884	PTPRC/CD4	0.159993244964818
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	5/442	104/9376	1.01983988861817	LPIN2/LPCAT3/DGKH/PLD1/PLD3	0.0452525426804513
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/442	17/9376	1.24780409901517	CYP27A1	0.227453184577225
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/442	17/9376	1.24780409901517	CDO1	0.227453184577225
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/442	17/9376	1.24780409901517	MYH10	0.227453184577225
Cellular Processes	Cell motility	hsa04814	Motor proteins	9/442	194/9376	0.98409292345011	DYNLT1/MYL6/DYNLRB1/MYL12A/TNNC1/MYH10/ACTG2/TUBA1A/MYL12B	-0.0497962215605337
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	5/442	107/9376	0.991246246881211	CALM2/FBP1/PRKAG2/CREB5/PPP4C	-0.0202555267058843
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	10/442	217/9376	0.977542381716955	GSTT1/GSTA3/EPHX2/ADRB1/KLF4/NOTCH2/CREB5/RB1/FGF2/KRAS	-0.0744463366677802
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	3/442	63/9376	1.01012712777419	PCNA/DDB2/RPA3	0.0179384767300718
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	6/442	130/9376	0.979046293073442	MMP9/GNG5/NFKBIA/TGFBR1/CREB5/KRAS	-0.0535093155285501
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/442	18/9376	1.17848164906988	HEXB	0.168582348971542
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/442	18/9376	1.17848164906988	PRDX1	0.168582348971542
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	2/442	41/9376	1.03476437479307	SDS/SDSL	0.0496184266833327
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	4/442	86/9376	0.986635799221299	ITGB6/ITGA5/TCF7L1/CACNA2D3	-0.0276922446083536
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	7/442	154/9376	0.964212258329905	CALM2/PPP2R2B/TNNC1/ATP1B1/ADRB1/CREB5/CACNA2D3	-0.0995992100810759
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/442	42/9376	1.01012712777419	AOC1/IL4I1	0.014630219273273
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	3/442	65/9376	0.979046293073442	SPP1/KISS1/KRAS	-0.0377044994003987
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/442	19/9376	1.11645629911884	HEXB	0.113017388818176
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	7/442	155/9376	0.957991534082616	CDKN2A/CDKN1A/CRH/TCF7L1/CCNE2/CREB5/RB1	-0.117297149699205
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	7/442	157/9376	0.945787820272646	SERPINE1/ITGB2/PPP2R2B/TGFBR1/YWHAH/BBC3/TCF7L1	-0.152362674335121
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	4/442	90/9376	0.942785319255907	SESN1/PRKAG2/CREB5/KRAS	-0.121307650904925
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	4/442	90/9376	0.942785319255907	NFKBIA/CD4/NFATC2/KRAS	-0.121307650904925
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/442	20/9376	1.0606334841629	LIPA	0.0603748708505023
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	2/442	44/9376	0.964212258329905	HEXB/MAN1A1	-0.052923318186142
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	2/442	44/9376	0.964212258329905	PCNA/HMGB1	-0.052923318186142
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	5/442	115/9376	0.922289986228605	DUSP1/GNG5/ALOX5/PTGS2/KRAS	-0.186496533081354
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/442	21/9376	1.01012712777419	DSE	0.0103335094214855
Organismal Systems	Endocrine system	hsa04924	Renin secretion	3/442	69/9376	0.922289986228605	CTSB/CALM2/ADRB1	-0.144102154186999
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	3/442	69/9376	0.922289986228605	CALM2/CREB5/FOSB	-0.144102154186999
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	6/442	138/9376	0.922289986228605	CALM2/FBP1/RHOQ/PRKAG2/PPP1R3D/KRAS	-0.204550878471807
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	4/442	93/9376	0.912372889602491	CALM2/HBEGF/PLD1/KRAS	-0.188890270457078
Organismal Systems	Digestive system	hsa04970	Salivary secretion	4/442	93/9376	0.912372889602491	LYZ/CALM2/ATP1B1/ADRB1	-0.188890270457078
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/442	22/9376	0.964212258329905	AOC1	-0.0373784036961991
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	2/442	47/9376	0.902666795032252	ACSS1/ACYP1	-0.148787417297603
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/442	23/9376	0.922289986228605	GLUL	-0.0829925742300028
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/442	23/9376	0.922289986228605	ATP1B1	-0.0829925742300028
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	5/442	120/9376	0.883861236802413	CALM2/NFKBIA/PLCG2/ARHGDIB/KRAS	-0.28479341651641
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	9/442	212/9376	0.900537863911893	ITGB2/CALM2/RRAS/LCP2/MRAS/FGF2/FPR1/RALGDS/KRAS	-0.325804419440366
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3/442	73/9376	0.871753548627038	GSTT1/GSTP1/GSTA3	-0.244663438631116
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	6/442	144/9376	0.883861236802413	ISL1/SKIL/KLF4/FGF2/INHBA/KRAS	-0.312380807858385
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	2/442	49/9376	0.865823252377874	GALNT18/GALNT11	-0.209448913109171
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	2/442	49/9376	0.865823252377874	CREB5/FOSB	-0.209448913109171
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	7/442	168/9376	0.883861236802413	CSH1/CSH2/CDKN1A/PIM1/OSM/CSHL1/GH2	-0.337849267087474
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	4/442	98/9376	0.865823252377874	CALM2/NR4A2/ATP1B1/CREB5	-0.296986640142453
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	10/442	238/9376	0.891288642153694	IGF2/CALM2/GNG5/RRAS/PLCG2/MRAS/PLD1/FGF2/RALGDS/KRAS	-0.377843208768271
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	3/442	75/9376	0.848506787330317	SDS/GLUL/SDSL	-0.29297649830436
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	2/442	53/9376	0.800478101255016	CLTB/ATP1B1	-0.323984669586215
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	4/442	103/9376	0.823792997408074	COL17A1/SLC7A7/COL14A1/ATP1B1	-0.399949764000292
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3/442	79/9376	0.805544418351567	GSTT1/GSTP1/GSTA3	-0.386043587277512
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	2/442	54/9376	0.785654432713256	RMI2/RPA3	-0.351342458605668
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/442	28/9376	0.75759534583064	GGH	-0.285715904762605
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	9/442	226/9376	0.844752332519121	CALM2/NFKBIA/RRAS/CNGB1/CRH/ATP1B1/ADRB1/PLD1/CREB5	-0.525463501146097
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/442	29/9376	0.731471368388204	RASSF4	-0.322127109159316
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	2/442	57/9376	0.744304199412558	ACADVL/ACADL	-0.430675499650118
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	5/442	134/9376	0.791517525494698	MYL6/CALM2/NPPB/MYH10/ACTG2	-0.540645719661971
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/442	31/9376	0.684279667201868	FBP1	-0.391622418204956
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/442	60/9376	0.707088989441931	CRH/KRAS	-0.506256230631144
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/442	32/9376	0.66289592760181	ACSS1	-0.424860515918918
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	2/442	62/9376	0.684279667201868	NOTCH2/ATXN1	-0.554758644943586
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	3/442	89/9376	0.71503380954802	ADRB1/TUBA1A/KRAS	-0.600792380263396
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	4/442	116/9376	0.731471368388204	SDS/FBP1/ACSS1/SDSL	-0.647273607122141
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	4/442	116/9376	0.731471368388204	GNG5/GLUL/HOMER3/PLD1	-0.647273607122141
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	5/442	142/9376	0.74692498884711	UBE2I/BIRC7/UBE2L6/NEDD4L/DDB2	-0.675884209955514
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/442	34/9376	0.623902049507586	PRKAG2	-0.488645937667637
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	2/442	67/9376	0.633214020395759	FBP1/ACSS1	-0.670150601006282
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	2/442	67/9376	0.633214020395759	CALM2/KRAS	-0.670150601006282
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/442	37/9376	0.573315396844809	IL4I1	-0.578404209281844
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/442	68/9376	0.623902049507586	DHRS4L2/ALDH1A1	-0.692310685239904
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1/442	38/9376	0.558228149559419	HEXB	-0.60692734030621
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/442	39/9376	0.543914607263024	TYMS	-0.63481705503844
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	2/442	70/9376	0.606076276664512	CDKN1A/KRAS	-0.735789237248473
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	3/442	99/9376	0.642808172219937	IL1B/CALM2/PLCG2	-0.794674233845322
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	9/442	254/9376	0.751630028146934	CALM2/CXCR4/TNNC1/PLCG2/ORAI3/SLC25A5/NFATC2/ADRB1/FGF2	-0.892574984943284
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	2/442	71/9376	0.597539991077688	IRF1/KRAS	-0.757124878399037
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	3/442	101/9376	0.630079297522512	CALM2/TCF7L1/KRAS	-0.831354331127883
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	1/442	41/9376	0.517382187396535	RPA3	-0.688829777416553
NA	NA	hsa04519	Cadherin signaling	15/442	404/9376	0.787599121903141	VIM/KRT8/KRT7/NFKBIA/CDH8/ARPC2/YWHAH/RRAS/NCKAP1L/TCF7L1/MRAS/KRT18/KRT14/ARPC5/KRAS	-0.970680168286836
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	2/442	75/9376	0.565671191553545	ATP1B1/CREB5	-0.839959303581476
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/442	43/9376	0.493317899610649	CD36	-0.740683987387047
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	4/442	133/9376	0.637975028067907	CALM2/GNG5/PPP2R2B/CREB5	-0.93525851589846
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	2/442	76/9376	0.558228149559419	CALM2/ATP1B1	-0.860076655359327
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	2/442	78/9376	0.543914607263024	BTG3/BTG2	-0.899647737994608
Human Diseases	Substance dependence	hsa05034	Alcoholism	6/442	191/9376	0.666366586908626	CALM2/GNG5/CRH/CREB5/FOSB/KRAS	-1.03614477298161
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	4/442	138/9376	0.61485999081907	CALM2/YWHAH/SMC1B/CCNE2	-1.01377832005479
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	13/442	370/9376	0.745310015898251	CSH1/CSH2/KISS1/C5AR1/FPR3/TAC3/CRH/C3AR1/CSHL1/GH2/ADRB1/CHRNB1/FPR1	-1.11178434850895
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/442	47/9376	0.451333397516126	TNF	-0.838713641126644
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/442	48/9376	0.441930618401207	IL4I1	-0.862160942174912
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/442	48/9376	0.441930618401207	ATP1B1	-0.862160942174912
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/442	50/9376	0.424253393665158	AOC1	-0.907909336437364
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	3/442	115/9376	0.553373991737163	GNG5/CREB5/KRAS	-1.07185931493998
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	4/442	144/9376	0.589240824534942	WIPI1/SLC25A5/PSMD7/ATXN1	-1.10482735939524
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	2/442	86/9376	0.493317899610649	ATP1B1/CREB5	-1.04990675424585
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	3/442	117/9376	0.543914607263024	SMARCA1/SRCAP/BCL7C	-1.10415705251648
Organismal Systems	Digestive system	hsa04976	Bile secretion	2/442	90/9376	0.471392659627954	ATP1B1/AQP9	-1.12076330546079
Human Diseases	Substance dependence	hsa05032	Morphine addiction	2/442	91/9376	0.466212520511163	GNG5/PDE7A	-1.13807772628044
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	1/442	56/9376	0.37879767291532	MAN1A1	-1.03703384427064
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	4/442	158/9376	0.537029612234378	LPIN2/ATP6V1D/TNF/KRAS	-1.30538075059013
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	3/442	128/9376	0.497171945701357	GMPR/NME4/PDE7A	-1.27401450733998
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	2/442	97/9376	0.437374632644493	CALM2/GNG5	-1.23887756434332
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	1/442	63/9376	0.336709042591396	PLOD2	-1.17490661420009
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	1/442	65/9376	0.326348764357814	CREB5	-1.21218086610517
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/442	66/9376	0.321404086109968	HSD17B1	-1.23050155350533
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	4/442	174/9376	0.487647578925469	MAN1A1/HSPA6/HSPA4L/NFE2L2	-1.5173162228853
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	1/442	71/9376	0.298769995538844	KRAS	-1.31918369549083
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	3/442	154/9376	0.413233824998531	GGH/NME4/PNPO	-1.63300182702716
NA	NA	hsa04082	Neuroactive ligand signaling	4/442	199/9376	0.426385320266491	GNG5/TAC3/ADRB1/SLC6A2	-1.81915719418093
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	3/442	178/9376	0.35751690477401	MMP7/TCF7L1/NFATC2	-1.92485847028502
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	1/442	102/9376	0.207967349835862	ATP1B1	-1.78888912493573
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	1/442	103/9376	0.205948249352019	PPP2R2B	-1.80231662535659
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	1/442	108/9376	0.196413608178314	UBE2I	-1.86820804378957
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	1/442	110/9376	0.192842451665981	KRAS	-1.89401016713163
Genetic Information Processing	Transcription	hsa03040	Spliceosome	2/442	243/9376	0.174589873936279	CTNNBL1/HSPA6	-2.89961274003397
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	3/442	449/9376	0.141732759576334	CALM2/RGS2/CNGB1	-4.14540281504912