ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0023026 MHC class II protein complex binding 15/681 27/18639 0.555555555555556 15.2055800293686 2.74404773603357e-15 2.53001201262295e-12 GO:0023023 MHC protein complex binding 16/681 37/18639 0.432432432432432 11.8356947255626 5.33947339198483e-14 2.46149723370501e-11 GO:0042605 peptide antigen binding 14/681 45/18639 0.311111111111111 8.5151248164464 3.86637031017488e-10 1.18826447532708e-07 GO:0042277 peptide binding 29/681 249/18639 0.116465863453815 3.1876758133857 3.78925082437897e-08 8.73422315019353e-06 GO:0140375 immune receptor activity 22/681 156/18639 0.141025641025641 3.8598780074551 5.73249958250942e-08 1.05707292301474e-05 GO:0098641 cadherin binding involved in cell-cell adhesion 8/681 18/18639 0.444444444444444 12.1644640234949 9.6402857837103e-08 1.2747496761247e-05 GO:0005126 cytokine receptor binding 30/681 275/18639 0.109090909090909 2.9858229875851 9.67814287730246e-08 1.2747496761247e-05 GO:0005125 cytokine activity 27/681 234/18639 0.115384615384615 3.15808200609963 1.35207499121306e-07 1.55826642737306e-05 GO:0032395 MHC class II receptor activity 6/681 10/18639 0.6 16.4220264317181 4.3110193399489e-07 4.03848198718473e-05 GO:0005178 integrin binding 21/681 161/18639 0.130434782608696 3.57000574602567 4.38013230714178e-07 4.03848198718473e-05 GO:0043394 proteoglycan binding 10/681 37/18639 0.27027027027027 7.3973092034766 5.65363742350544e-07 4.73877609497456e-05 GO:0004857 enzyme inhibitor activity 36/681 416/18639 0.0865384615384615 2.36856150457472 1.65812943078609e-06 0.000127399611265398 GO:0008009 chemokine activity 10/681 45/18639 0.222222222222222 6.08223201174743 3.9755433596077e-06 0.000281957767504484 GO:0019955 cytokine binding 18/681 144/18639 0.125 3.42125550660793 5.33006821354358e-06 0.000351023063777656 GO:0004866 endopeptidase inhibitor activity 19/681 161/18639 0.118012422360248 3.23000519878513 6.90665412386157e-06 0.000424529006813358 GO:0001540 amyloid-beta binding 13/681 83/18639 0.156626506024096 4.2868743697256 9.25132440564781e-06 0.000522153872380858 GO:0061134 peptidase regulator activity 23/681 226/18639 0.101769911504425 2.78544696113212 9.62756597665357e-06 0.000522153872380858 GO:0042379 chemokine receptor binding 12/681 72/18639 0.166666666666667 4.56167400881057 1.05785130809033e-05 0.000541854947810714 GO:0016209 antioxidant activity 13/681 86/18639 0.151162790697674 4.13733224054912 1.37675615966141e-05 0.000612741513702529 GO:0061135 endopeptidase regulator activity 20/681 184/18639 0.108695652173913 2.97500478835472 1.38301416127291e-05 0.000612741513702529 GO:0030414 peptidase inhibitor activity 19/681 169/18639 0.112426035502959 3.07710554440477 1.39561516136151e-05 0.000612741513702529 GO:0015078 proton transmembrane transporter activity 20/681 185/18639 0.108108108108108 2.95892368139064 1.49868921027081e-05 0.00062808702357713 GO:0003779 actin binding 35/681 443/18639 0.0790067720090293 2.16241883036167 1.69576472461777e-05 0.000679780467868517 GO:0140311 protein sequestering activity 8/681 33/18639 0.242424242424242 6.63516219463356 1.88091741279648e-05 0.000722585772749315 GO:0009055 electron transfer activity 15/681 116/18639 0.129310344827586 3.539229834422 2.12757894031457e-05 0.000784651113188014 GO:0019864 IgG binding 5/681 11/18639 0.454545454545455 12.4409291149379 2.46767386823609e-05 0.00086336023527172 GO:0022853 active monoatomic ion transmembrane transporter activity 15/681 118/18639 0.127118644067797 3.47924288807586 2.61369074544248e-05 0.00086336023527172 GO:0140313 molecular sequestering activity 10/681 55/18639 0.181818181818182 4.97637164597517 2.62191828499004e-05 0.00086336023527172 GO:0048306 calcium-dependent protein binding 12/681 80/18639 0.15 4.10550660792952 3.17792878379896e-05 0.00100977673080924 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 11/681 68/18639 0.161764705882353 4.4275071261985 3.28560758397799e-05 0.00100977673080924 GO:0004859 phospholipase inhibitor activity 5/681 12/18639 0.416666666666667 11.4041850220264 4.10306931985574e-05 0.00122033222997 GO:0035325 Toll-like receptor binding 5/681 13/18639 0.384615384615385 10.5269400203321 6.46713629940354e-05 0.00186334364626565 GO:0038024 cargo receptor activity 10/681 65/18639 0.153846153846154 4.21077600813284 0.00011555201516209 0.00322845327210445 GO:0005201 extracellular matrix structural constituent 17/681 168/18639 0.101190476190476 2.76958779106356 0.000146139952143334 0.00396297164341629 GO:0098632 cell-cell adhesion mediator activity 9/681 55/18639 0.163636363636364 4.47873448137765 0.000155288746330116 0.00402060906926631 GO:0019956 chemokine binding 7/681 33/18639 0.212121212121212 5.80576692030437 0.000156986905090658 0.00402060906926631 GO:0016675 oxidoreductase activity, acting on a heme group of donors 5/681 16/18639 0.3125 8.55313876651982 0.000200326188515898 0.00486054594241205 GO:0055102 lipase inhibitor activity 5/681 16/18639 0.3125 8.55313876651982 0.000200326188515898 0.00486054594241205 GO:0097110 scaffold protein binding 10/681 70/18639 0.142857142857143 3.91000629326621 0.000217381261367213 0.00513911597386078 GO:0005539 glycosaminoglycan binding 21/681 242/18639 0.0867768595041322 2.37508646739724 0.000230131202296132 0.00530452421292585 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 9/681 59/18639 0.152542372881356 4.17509146569103 0.000269509884574553 0.006060685697018 GO:0033218 amide binding 21/681 247/18639 0.0850202429149798 2.32700779396815 0.000303916447326968 0.00666911229378684 GO:0005131 growth hormone receptor binding 4/681 10/18639 0.4 10.9480176211454 0.000311032352096349 0.00666911229378684 GO:0035254 glutamate receptor binding 8/681 49/18639 0.163265306122449 4.46857862087566 0.000364979172249412 0.00764797265486268 GO:0098631 cell adhesion mediator activity 10/681 76/18639 0.131578947368421 3.60132158590308 0.000429873130269024 0.00880762280240089 GO:0042608 T cell receptor binding 4/681 11/18639 0.363636363636364 9.95274329195034 0.000474664131190057 0.0091227923511876 GO:0050786 RAGE receptor binding 4/681 11/18639 0.363636363636364 9.95274329195034 0.000474664131190057 0.0091227923511876 GO:0072341 modified amino acid binding 11/681 91/18639 0.120879120879121 3.30846686353294 0.00047493929810955 0.0091227923511876 GO:0008201 heparin binding 16/681 172/18639 0.0930232558139535 2.54605060956869 0.000583919531090474 0.0109872205646003 GO:0001530 lipopolysaccharide binding 7/681 41/18639 0.170731707317073 4.67293435048888 0.000641273199636437 0.0118250778012959 GO:0004875 complement receptor activity 4/681 12/18639 0.333333333333333 9.12334801762115 0.000691480850185807 0.012500889095516 GO:0001618 virus receptor activity 10/681 81/18639 0.123456790123457 3.37901778430413 0.000718578563729998 0.0127409506876742 GO:0140272 exogenous protein binding 10/681 82/18639 0.121951219512195 3.3378102503492 0.000792133116363965 0.0137801270431618 GO:0019207 kinase regulator activity 22/681 287/18639 0.0766550522648084 2.09805215736235 0.000903979117165829 0.0154047357999837 GO:0071813 lipoprotein particle binding 6/681 32/18639 0.1875 5.13188325991189 0.000935645558350419 0.0154047357999837 GO:0071814 protein-lipid complex binding 6/681 32/18639 0.1875 5.13188325991189 0.000935645558350419 0.0154047357999837 GO:0004601 peroxidase activity 8/681 57/18639 0.140350877192982 3.84140969162996 0.00103514364905254 0.0167439025337972 GO:0015399 primary active transmembrane transporter activity 15/681 166/18639 0.0903614457831325 2.47319675176477 0.00115256940736885 0.0183218791998979 GO:0005518 collagen binding 9/681 72/18639 0.125 3.42125550660793 0.0011987111819633 0.0187324018605113 GO:1901681 sulfur compound binding 21/681 275/18639 0.0763636363636364 2.09007609130957 0.00122791548305276 0.0188689679229107 GO:0001786 phosphatidylserine binding 8/681 59/18639 0.135593220338983 3.71119241394758 0.00130317575814065 0.0193042815749782 GO:0051427 hormone receptor binding 6/681 34/18639 0.176470588235294 4.83000777403472 0.0013052167649224 0.0193042815749782 GO:0019763 immunoglobulin receptor activity 4/681 14/18639 0.285714285714286 7.82001258653241 0.00131905611629461 0.0193042815749782 GO:0016651 oxidoreductase activity, acting on NAD(P)H 10/681 88/18639 0.113636363636364 3.11023227873448 0.00137475672024149 0.019805089000979 GO:0004129 cytochrome-c oxidase activity 4/681 15/18639 0.266666666666667 7.29867841409692 0.00174708412064881 0.0244062357460334 GO:0005041 low-density lipoprotein particle receptor activity 4/681 15/18639 0.266666666666667 7.29867841409692 0.00174708412064881 0.0244062357460334 GO:0051015 actin filament binding 17/681 209/18639 0.0813397129186603 2.226271525831 0.00178239444589465 0.0245278758076845 GO:0003735 structural constituent of ribosome 15/681 175/18639 0.0857142857142857 2.34600377595972 0.00195083961951506 0.0264510901351895 GO:0005507 copper ion binding 8/681 63/18639 0.126984126984127 3.47556114956996 0.00200351358296932 0.0267715872970683 GO:0048020 CCR chemokine receptor binding 7/681 50/18639 0.14 3.83180616740088 0.00214569922882181 0.0282619241281958 GO:0008198 ferrous iron binding 5/681 26/18639 0.192307692307692 5.26347001016605 0.00222892296259947 0.0285425968266209 GO:0019865 immunoglobulin binding 5/681 26/18639 0.192307692307692 5.26347001016605 0.00222892296259947 0.0285425968266209 GO:0008083 growth factor activity 14/681 162/18639 0.0864197530864197 2.36531244901289 0.00252072396823298 0.0318370890234357 GO:0035255 ionotropic glutamate receptor binding 5/681 27/18639 0.185185185185185 5.06852667645619 0.00265436831506525 0.0330719944120292 GO:0019887 protein kinase regulator activity 19/681 255/18639 0.0745098039215686 2.03933661570355 0.00270677791347688 0.0332753231496757 GO:0008429 phosphatidylethanolamine binding 4/681 17/18639 0.235294117647059 6.44001036537963 0.00287416909306693 0.0344153753741261 GO:0030169 low-density lipoprotein particle binding 4/681 17/18639 0.235294117647059 6.44001036537963 0.00287416909306693 0.0344153753741261 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 6/681 40/18639 0.15 4.10550660792952 0.00309520336822994 0.0363717264452566 GO:0001664 G protein-coupled receptor binding 21/681 297/18639 0.0707070707070707 1.93525564010145 0.00311644944596017 0.0363717264452566 GO:0005179 hormone activity 12/681 132/18639 0.0909090909090909 2.48818582298759 0.00330015116847173 0.0380342422166367 GO:0008137 NADH dehydrogenase (ubiquinone) activity 6/681 41/18639 0.146341463414634 4.00537230041904 0.0035158771114174 0.0400202308237882 GO:0030228 lipoprotein particle receptor activity 4/681 18/18639 0.222222222222222 6.08223201174743 0.00358970885756216 0.0403623361789306 GO:0042056 chemoattractant activity 6/681 42/18639 0.142857142857143 3.91000629326621 0.00397758917643201 0.0441847857912086 GO:0043395 heparan sulfate proteoglycan binding 4/681 19/18639 0.210526315789474 5.76211453744493 0.00441713889037044 0.0484833578204946 GO:0003823 antigen binding 14/681 174/18639 0.0804597701149425 2.20218745252924 0.00479983045016914 0.0504055086569461 GO:0005345 purine nucleobase transmembrane transporter activity 3/681 10/18639 0.3 8.21101321585903 0.00480704476026254 0.0504055086569461 GO:0016175 superoxide-generating NAD(P)H oxidase activity 3/681 10/18639 0.3 8.21101321585903 0.00480704476026254 0.0504055086569461 GO:0004197 cysteine-type endopeptidase activity 9/681 88/18639 0.102272727272727 2.79920905086103 0.00481093791953499 0.0504055086569461 GO:0003954 NADH dehydrogenase activity 6/681 44/18639 0.136363636363636 3.73227873448138 0.00503346666318985 0.0521444523984387 GO:0045296 cadherin binding 22/681 334/18639 0.0658682634730539 1.8028172729431 0.0058286691838098 0.0597114776385848 GO:0008199 ferric iron binding 3/681 11/18639 0.272727272727273 7.46455746896275 0.00643168749616472 0.0638204649604713 GO:0015205 nucleobase transmembrane transporter activity 3/681 11/18639 0.272727272727273 7.46455746896275 0.00643168749616472 0.0638204649604713 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 4/681 21/18639 0.19047619047619 5.21334172435494 0.00643742217063322 0.0638204649604713 GO:0031625 ubiquitin protein ligase binding 20/681 302/18639 0.0662251655629139 1.81258569886513 0.00785725902326107 0.0767661573325323 GO:0004867 serine-type endopeptidase inhibitor activity 9/681 95/18639 0.0947368421052632 2.59295154185022 0.00790974506137806 0.0767661573325323 GO:0004126 cytidine deaminase activity 3/681 12/18639 0.25 6.84251101321586 0.00834508971149103 0.078511966469334 GO:0016208 AMP binding 3/681 12/18639 0.25 6.84251101321586 0.00834508971149103 0.078511966469334 GO:0035259 nuclear glucocorticoid receptor binding 3/681 12/18639 0.25 6.84251101321586 0.00834508971149103 0.078511966469334 GO:0004602 glutathione peroxidase activity 4/681 23/18639 0.173913043478261 4.76000766136755 0.00899076119892523 0.0837321396505965 GO:0005543 phospholipid binding 29/681 497/18639 0.0583501006036217 1.59704482401014 0.00920956509287303 0.0849121901562893 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 22/681 349/18639 0.0630372492836676 1.72533228986532 0.00953030758861164 0.0869994415514844 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 4/681 24/18639 0.166666666666667 4.56167400881057 0.0104829637678479 0.0938377921743282 GO:0019957 C-C chemokine binding 4/681 24/18639 0.166666666666667 4.56167400881057 0.0104829637678479 0.0938377921743282 GO:0050840 extracellular matrix binding 7/681 67/18639 0.104477611940299 2.85955684134394 0.0109845074525592 0.0973818833774956 GO:0002020 protease binding 11/681 136/18639 0.0808823529411765 2.21375356309925 0.011255606809074 0.0988349474092024 GO:0004860 protein kinase inhibitor activity 8/681 84/18639 0.0952380952380952 2.60667086217747 0.011598607067561 0.100885997323502 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 4/681 25/18639 0.16 4.37920704845815 0.0121263161906305 0.104490313343564 GO:0008191 metalloendopeptidase inhibitor activity 3/681 14/18639 0.214285714285714 5.86500943989931 0.0130772000412165 0.109610713072742 GO:0032036 myosin heavy chain binding 3/681 14/18639 0.214285714285714 5.86500943989931 0.0130772000412165 0.109610713072742 GO:0044548 S100 protein binding 3/681 14/18639 0.214285714285714 5.86500943989931 0.0130772000412165 0.109610713072742 GO:0030247 polysaccharide binding 4/681 26/18639 0.153846153846154 4.21077600813284 0.0139258422320907 0.114639522660604 GO:0043548 phosphatidylinositol 3-kinase binding 4/681 26/18639 0.153846153846154 4.21077600813284 0.0139258422320907 0.114639522660604 GO:0044389 ubiquitin-like protein ligase binding 20/681 322/18639 0.062111801242236 1.7000027362027 0.0150941324619931 0.123157434778386 GO:0004364 glutathione transferase activity 4/681 27/18639 0.148148148148148 4.05482134116495 0.0158860985654865 0.126454915152521 GO:0005044 scavenger receptor activity 4/681 27/18639 0.148148148148148 4.05482134116495 0.0158860985654865 0.126454915152521 GO:0050700 CARD domain binding 3/681 15/18639 0.2 5.47400881057269 0.0159097290213584 0.126454915152521 GO:0042287 MHC protein binding 5/681 41/18639 0.121951219512195 3.3378102503492 0.0162184229474258 0.127806717585698 GO:0019210 kinase inhibitor activity 8/681 90/18639 0.0888888888888889 2.43289280469897 0.0170805516659773 0.133459903695178 GO:0048487 beta-tubulin binding 5/681 42/18639 0.119047619047619 3.25833857772184 0.0178725896732358 0.138475022510281 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 6/681 58/18639 0.103448275862069 2.8313838675376 0.0188257236170336 0.142865401520912 GO:0000062 fatty-acyl-CoA binding 3/681 16/18639 0.1875 5.13188325991189 0.0190590503113581 0.142865401520912 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 3/681 16/18639 0.1875 5.13188325991189 0.0190590503113581 0.142865401520912 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 3/681 16/18639 0.1875 5.13188325991189 0.0190590503113581 0.142865401520912 GO:0019209 kinase activator activity 11/681 148/18639 0.0743243243243243 2.03426003095607 0.0200501295375299 0.148149099059904 GO:0031406 carboxylic acid binding 13/681 187/18639 0.0695187165775401 1.9027303352258 0.0200852900026985 0.148149099059904 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 4/681 29/18639 0.137931034482759 3.77517849005013 0.0203046733666812 0.148578641619683 GO:0043177 organic acid binding 13/681 189/18639 0.0687830687830688 1.88259562268373 0.0217098725228222 0.157610255638126 GO:0016805 dipeptidase activity 3/681 17/18639 0.176470588235294 4.83000777403472 0.022527239143849 0.158550492294876 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 3/681 17/18639 0.176470588235294 4.83000777403472 0.022527239143849 0.158550492294876 GO:0036041 long-chain fatty acid binding 3/681 17/18639 0.176470588235294 4.83000777403472 0.022527239143849 0.158550492294876 GO:1901567 fatty acid derivative binding 3/681 17/18639 0.176470588235294 4.83000777403472 0.022527239143849 0.158550492294876 GO:0141110 transporter inhibitor activity 5/681 45/18639 0.111111111111111 3.04111600587372 0.0234905905881564 0.16407821607788 GO:0005164 tumor necrosis factor receptor binding 4/681 31/18639 0.129032258064516 3.53161858746625 0.0254090795408747 0.176069327497422 GO:0030291 protein serine/threonine kinase inhibitor activity 5/681 46/18639 0.108695652173913 2.97500478835472 0.0255892515017945 0.176069327497422 GO:0034185 apolipoprotein binding 3/681 18/18639 0.166666666666667 4.56167400881057 0.0263147452011064 0.178398493201618 GO:0050811 GABA receptor binding 3/681 18/18639 0.166666666666667 4.56167400881057 0.0263147452011064 0.178398493201618 GO:0005504 fatty acid binding 5/681 47/18639 0.106382978723404 2.91170681413441 0.0278042153375495 0.187120339716939 GO:0051059 NF-kappaB binding 4/681 32/18639 0.125 3.42125550660793 0.0282248813918014 0.188574932197398 GO:0030246 carbohydrate binding 17/681 280/18639 0.0607142857142857 1.66175267463814 0.0287487447399155 0.190693112591382 GO:0038187 pattern recognition receptor activity 5/681 48/18639 0.104166666666667 2.85104625550661 0.0301371951736195 0.196138068296424 GO:0008301 DNA binding, bending 3/681 19/18639 0.157894736842105 4.3215859030837 0.0304205463843694 0.196138068296424 GO:0070003 threonine-type peptidase activity 3/681 19/18639 0.157894736842105 4.3215859030837 0.0304205463843694 0.196138068296424 GO:0120227 acyl-CoA binding 3/681 19/18639 0.157894736842105 4.3215859030837 0.0304205463843694 0.196138068296424 GO:0030296 protein tyrosine kinase activator activity 4/681 33/18639 0.121212121212121 3.31758109731678 0.0312189241787907 0.19988783397809 GO:0030295 protein kinase activator activity 10/681 139/18639 0.0719424460431655 1.96906791747219 0.0314516752008319 0.199989272656324 GO:0016004 phospholipase activator activity 3/681 20/18639 0.15 4.10550660792952 0.034842292172491 0.218534648864195 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 3/681 20/18639 0.15 4.10550660792952 0.034842292172491 0.218534648864195 GO:0032813 tumor necrosis factor receptor superfamily binding 5/681 50/18639 0.1 2.73700440528634 0.035163139220349 0.219056853791634 GO:0005154 epidermal growth factor receptor binding 4/681 35/18639 0.114285714285714 3.12800503461296 0.0377466132985615 0.232203307100327 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 7/681 86/18639 0.0813953488372093 2.22779428337261 0.0377771106996193 0.232203307100327 GO:1901981 phosphatidylinositol phosphate binding 12/681 185/18639 0.0648648648648649 1.77535420883438 0.0393637622600392 0.240353568236796 GO:0004869 cysteine-type endopeptidase inhibitor activity 4/681 36/18639 0.111111111111111 3.04111600587372 0.0412816382556125 0.250405726787334 GO:0008234 cysteine-type peptidase activity 12/681 187/18639 0.0641711229946524 1.75636646328535 0.0421637127534034 0.254084595808091 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 5/681 54/18639 0.0925925925925926 2.5342633382281 0.0466862094243393 0.279510942137927 GO:0042887 amide transmembrane transporter activity 4/681 38/18639 0.105263157894737 2.88105726872247 0.0488944485311543 0.281042887976431 GO:0004090 carbonyl reductase (NADPH) activity 2/681 10/18639 0.2 5.47400881057269 0.0493806375837114 0.281042887976431 GO:0005031 tumor necrosis factor receptor activity 2/681 10/18639 0.2 5.47400881057269 0.0493806375837114 0.281042887976431 GO:0005381 iron ion transmembrane transporter activity 2/681 10/18639 0.2 5.47400881057269 0.0493806375837114 0.281042887976431 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 2/681 10/18639 0.2 5.47400881057269 0.0493806375837114 0.281042887976431 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 2/681 10/18639 0.2 5.47400881057269 0.0493806375837114 0.281042887976431 GO:0035256 G protein-coupled glutamate receptor binding 2/681 10/18639 0.2 5.47400881057269 0.0493806375837114 0.281042887976431 GO:0050308 sugar-phosphatase activity 2/681 10/18639 0.2 5.47400881057269 0.0493806375837114 0.281042887976431 GO:0016493 C-C chemokine receptor activity 3/681 23/18639 0.130434782608696 3.57000574602567 0.0499625060707028 0.28261000366373 GO:1902936 phosphatidylinositol bisphosphate binding 8/681 111/18639 0.0720720720720721 1.97261578759376 0.0505948520976602 0.28444179045148 GO:0170055 lipid transmembrane transporter activity 5/681 56/18639 0.0892857142857143 2.44375393329138 0.0531946004448178 0.297244979455285 GO:0042625 ATPase-coupled ion transmembrane transporter activity 3/681 24/18639 0.125 3.42125550660793 0.0556024406853964 0.303345859833937 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 3/681 24/18639 0.125 3.42125550660793 0.0556024406853964 0.303345859833937 GO:0046961 proton-transporting ATPase activity, rotational mechanism 3/681 24/18639 0.125 3.42125550660793 0.0556024406853964 0.303345859833937 GO:0060229 lipase activator activity 3/681 24/18639 0.125 3.42125550660793 0.0556024406853964 0.303345859833937 GO:0001851 complement component C3b binding 2/681 11/18639 0.181818181818182 4.97637164597517 0.0589248487142773 0.306941867313919 GO:0010854 adenylate cyclase regulator activity 2/681 11/18639 0.181818181818182 4.97637164597517 0.0589248487142773 0.306941867313919 GO:0015217 ADP transmembrane transporter activity 2/681 11/18639 0.181818181818182 4.97637164597517 0.0589248487142773 0.306941867313919 GO:0016176 superoxide-generating NADPH oxidase activator activity 2/681 11/18639 0.181818181818182 4.97637164597517 0.0589248487142773 0.306941867313919 GO:0019203 carbohydrate phosphatase activity 2/681 11/18639 0.181818181818182 4.97637164597517 0.0589248487142773 0.306941867313919 GO:0019215 intermediate filament binding 2/681 11/18639 0.181818181818182 4.97637164597517 0.0589248487142773 0.306941867313919 GO:0032404 mismatch repair complex binding 2/681 11/18639 0.181818181818182 4.97637164597517 0.0589248487142773 0.306941867313919 GO:1990948 ubiquitin ligase inhibitor activity 2/681 11/18639 0.181818181818182 4.97637164597517 0.0589248487142773 0.306941867313919 GO:0001848 complement binding 3/681 25/18639 0.12 3.28440528634361 0.0615310031165007 0.314719697922328 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 3/681 25/18639 0.12 3.28440528634361 0.0615310031165007 0.314719697922328 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 3/681 25/18639 0.12 3.28440528634361 0.0615310031165007 0.314719697922328 GO:0004896 cytokine receptor activity 7/681 96/18639 0.0729166666666667 1.99573237885463 0.0617833680303052 0.314719697922328 GO:1990782 protein tyrosine kinase binding 8/681 117/18639 0.0683760683760684 1.87145600361459 0.064941659141604 0.326439067049628 GO:0001637 G protein-coupled chemoattractant receptor activity 3/681 26/18639 0.115384615384615 3.15808200609963 0.0677403719275108 0.326439067049628 GO:0004529 DNA exonuclease activity 3/681 26/18639 0.115384615384615 3.15808200609963 0.0677403719275108 0.326439067049628 GO:0004950 chemokine receptor activity 3/681 26/18639 0.115384615384615 3.15808200609963 0.0677403719275108 0.326439067049628 GO:0050750 low-density lipoprotein particle receptor binding 3/681 26/18639 0.115384615384615 3.15808200609963 0.0677403719275108 0.326439067049628 GO:0033293 monocarboxylic acid binding 6/681 79/18639 0.0759493670886076 2.07873752300229 0.0688130902252009 0.326439067049628 GO:0046332 SMAD binding 6/681 79/18639 0.0759493670886076 2.07873752300229 0.0688130902252009 0.326439067049628 GO:0003995 acyl-CoA dehydrogenase activity 2/681 12/18639 0.166666666666667 4.56167400881057 0.0690408005148345 0.326439067049628 GO:0008603 cAMP-dependent protein kinase regulator activity 2/681 12/18639 0.166666666666667 4.56167400881057 0.0690408005148345 0.326439067049628 GO:0015132 prostaglandin transmembrane transporter activity 2/681 12/18639 0.166666666666667 4.56167400881057 0.0690408005148345 0.326439067049628 GO:0016840 carbon-nitrogen lyase activity 2/681 12/18639 0.166666666666667 4.56167400881057 0.0690408005148345 0.326439067049628 GO:0035497 cAMP response element binding 2/681 12/18639 0.166666666666667 4.56167400881057 0.0690408005148345 0.326439067049628 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 2/681 12/18639 0.166666666666667 4.56167400881057 0.0690408005148345 0.326439067049628 GO:0097371 MDM2/MDM4 family protein binding 2/681 12/18639 0.166666666666667 4.56167400881057 0.0690408005148345 0.326439067049628 GO:0008200 ion channel inhibitor activity 4/681 43/18639 0.0930232558139535 2.54605060956869 0.0710526966490226 0.333750246909107 GO:0015026 coreceptor activity 5/681 61/18639 0.0819672131147541 2.24344623384127 0.0716519511109443 0.333750246909107 GO:0003714 transcription corepressor activity 12/681 204/18639 0.0588235294117647 1.61000259134491 0.0716730465162725 0.333750246909107 GO:0042578 phosphoric ester hydrolase activity 19/681 363/18639 0.0523415977961433 1.4325918374777 0.0749416799105114 0.347217230540159 GO:0016248 channel inhibitor activity 4/681 44/18639 0.0909090909090909 2.48818582298759 0.0760073324938083 0.349807283411252 GO:0022804 active transmembrane transporter activity 23/681 457/18639 0.050328227571116 1.37748580572398 0.0763183972567049 0.349807283411252 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 2/681 13/18639 0.153846153846154 4.21077600813284 0.0796741101045152 0.349807283411252 GO:0005035 death receptor activity 2/681 13/18639 0.153846153846154 4.21077600813284 0.0796741101045152 0.349807283411252 GO:0005542 folic acid binding 2/681 13/18639 0.153846153846154 4.21077600813284 0.0796741101045152 0.349807283411252 GO:0008035 high-density lipoprotein particle binding 2/681 13/18639 0.153846153846154 4.21077600813284 0.0796741101045152 0.349807283411252 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 2/681 13/18639 0.153846153846154 4.21077600813284 0.0796741101045152 0.349807283411252 GO:0017154 semaphorin receptor activity 2/681 13/18639 0.153846153846154 4.21077600813284 0.0796741101045152 0.349807283411252 GO:0035673 oligopeptide transmembrane transporter activity 2/681 13/18639 0.153846153846154 4.21077600813284 0.0796741101045152 0.349807283411252 GO:0071714 icosanoid transmembrane transporter activity 2/681 13/18639 0.153846153846154 4.21077600813284 0.0796741101045152 0.349807283411252 GO:0089720 caspase binding 2/681 13/18639 0.153846153846154 4.21077600813284 0.0796741101045152 0.349807283411252 GO:0004180 carboxypeptidase activity 4/681 46/18639 0.0869565217391304 2.38000383068378 0.0864205995050338 0.37762934949593 GO:0003785 actin monomer binding 3/681 29/18639 0.103448275862069 2.8313838675376 0.0879670282726646 0.380777465105149 GO:0043236 laminin binding 3/681 29/18639 0.103448275862069 2.8313838675376 0.0879670282726646 0.380777465105149 GO:0005347 ATP transmembrane transporter activity 2/681 14/18639 0.142857142857143 3.91000629326621 0.0907735951150651 0.389270952074837 GO:0071933 Arp2/3 complex binding 2/681 14/18639 0.142857142857143 3.91000629326621 0.0907735951150651 0.389270952074837 GO:0141108 transporter regulator activity 10/681 170/18639 0.0588235294117647 1.61000259134491 0.0942983105581573 0.401974782748631 GO:0050660 flavin adenine dinucleotide binding 6/681 86/18639 0.0697674418604651 1.90953795717652 0.0946079477835716 0.401974782748631 GO:0001968 fibronectin binding 3/681 30/18639 0.1 2.73700440528634 0.0952111703000936 0.40268210558113 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 4/681 48/18639 0.0833333333333333 2.28083700440529 0.0974856583343998 0.408553531746894 GO:0140693 molecular condensate scaffold activity 4/681 48/18639 0.0833333333333333 2.28083700440529 0.0974856583343998 0.408553531746894 GO:0008081 phosphoric diester hydrolase activity 6/681 87/18639 0.0689655172413793 1.88758924502506 0.0986644813396377 0.411622858801566 GO:0019842 vitamin binding 9/681 150/18639 0.06 1.64220264317181 0.0991750673387875 0.411889243632261 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 2/681 15/18639 0.133333333333333 3.64933920704846 0.102291112975635 0.42080065960432 GO:0055105 ubiquitin-protein transferase inhibitor activity 2/681 15/18639 0.133333333333333 3.64933920704846 0.102291112975635 0.42080065960432 GO:0070325 lipoprotein particle receptor binding 3/681 31/18639 0.0967741935483871 2.64871394059969 0.102689965738581 0.42080065960432 GO:0016298 lipase activity 8/681 130/18639 0.0615384615384615 1.68431040325313 0.103887451288254 0.423784948496859 GO:0004620 phospholipase activity 7/681 109/18639 0.0642201834862385 1.75770925110132 0.1043375090117 0.423784948496859 GO:0004175 endopeptidase activity 20/681 405/18639 0.0493827160493827 1.35160711372165 0.107223795990708 0.433597982032599 GO:0005506 iron ion binding 9/681 154/18639 0.0584415584415584 1.59954802906345 0.111822681981029 0.450220579853751 GO:0005149 interleukin-1 receptor binding 2/681 16/18639 0.125 3.42125550660793 0.114181407641961 0.455737046951895 GO:0005159 insulin-like growth factor receptor binding 2/681 16/18639 0.125 3.42125550660793 0.114181407641961 0.455737046951895 GO:0016597 amino acid binding 4/681 51/18639 0.0784313725490196 2.14667012179321 0.115244639065281 0.457998091457712 GO:0019239 deaminase activity 3/681 33/18639 0.0909090909090909 2.48818582298759 0.118310682940918 0.466164314835584 GO:0071889 14-3-3 protein binding 3/681 33/18639 0.0909090909090909 2.48818582298759 0.118310682940918 0.466164314835584 GO:0005080 protein kinase C binding 4/681 52/18639 0.0769230769230769 2.10538800406642 0.121458599437055 0.474511985936291 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 4/681 52/18639 0.0769230769230769 2.10538800406642 0.121458599437055 0.474511985936291 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 2/681 17/18639 0.117647058823529 3.22000518268982 0.126401963441709 0.479712403505831 GO:0015347 sodium-independent organic anion transmembrane transporter activity 2/681 17/18639 0.117647058823529 3.22000518268982 0.126401963441709 0.479712403505831 GO:0017110 nucleoside diphosphate phosphatase activity 2/681 17/18639 0.117647058823529 3.22000518268982 0.126401963441709 0.479712403505831 GO:0045236 CXCR chemokine receptor binding 2/681 17/18639 0.117647058823529 3.22000518268982 0.126401963441709 0.479712403505831 GO:0048038 quinone binding 2/681 17/18639 0.117647058823529 3.22000518268982 0.126401963441709 0.479712403505831 GO:0070403 NAD+ binding 2/681 17/18639 0.117647058823529 3.22000518268982 0.126401963441709 0.479712403505831 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 3/681 34/18639 0.0882352941176471 2.41500388701736 0.126431793982556 0.479712403505831 GO:0005544 calcium-dependent phospholipid binding 4/681 53/18639 0.0754716981132075 2.0656637021029 0.127812816256843 0.482964822085283 GO:0140297 DNA-binding transcription factor binding 23/681 488/18639 0.0471311475409836 1.28998158445873 0.128376178015332 0.4831136168577 GO:0099106 ion channel regulator activity 9/681 160/18639 0.05625 1.53956497797357 0.13238636242809 0.496179781132922 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 4/681 54/18639 0.0740740740740741 2.02741067058248 0.134302944803443 0.501325162383702 GO:0070851 growth factor receptor binding 8/681 139/18639 0.0575539568345324 1.57525433397775 0.137033011520405 0.502265341943078 GO:0008237 metallopeptidase activity 10/681 184/18639 0.0543478260869565 1.48750239417736 0.137496646378594 0.502265341943078 GO:0008409 5'-3' exonuclease activity 2/681 18/18639 0.111111111111111 3.04111600587372 0.138912865721784 0.502265341943078 GO:0016854 racemase and epimerase activity 2/681 18/18639 0.111111111111111 3.04111600587372 0.138912865721784 0.502265341943078 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 2/681 18/18639 0.111111111111111 3.04111600587372 0.138912865721784 0.502265341943078 GO:0035615 clathrin adaptor activity 2/681 18/18639 0.111111111111111 3.04111600587372 0.138912865721784 0.502265341943078 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 2/681 18/18639 0.111111111111111 3.04111600587372 0.138912865721784 0.502265341943078 GO:0070064 proline-rich region binding 2/681 18/18639 0.111111111111111 3.04111600587372 0.138912865721784 0.502265341943078 GO:0004033 aldo-keto reductase (NADPH) activity 3/681 36/18639 0.0833333333333333 2.28083700440529 0.143242792527687 0.515897869962998 GO:0017022 myosin binding 5/681 76/18639 0.0657894736842105 1.80066079295154 0.144770112394237 0.519369819562206 GO:0030170 pyridoxal phosphate binding 4/681 56/18639 0.0714285714285714 1.9550031466331 0.147672976784555 0.527730560447129 GO:0020037 heme binding 8/681 142/18639 0.0563380281690141 1.54197431283738 0.149141922729168 0.530922211414259 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 2/681 19/18639 0.105263157894737 2.88105726872247 0.151676667996774 0.531733414041923 GO:0005346 purine ribonucleotide transmembrane transporter activity 2/681 19/18639 0.105263157894737 2.88105726872247 0.151676667996774 0.531733414041923 GO:0015245 fatty acid transmembrane transporter activity 2/681 19/18639 0.105263157894737 2.88105726872247 0.151676667996774 0.531733414041923 GO:0042577 lipid phosphatase activity 2/681 19/18639 0.105263157894737 2.88105726872247 0.151676667996774 0.531733414041923 GO:0016504 peptidase activator activity 4/681 57/18639 0.0701754385964912 1.92070484581498 0.15454365004847 0.535834405577262 GO:0070279 vitamin B6 binding 4/681 57/18639 0.0701754385964912 1.92070484581498 0.15454365004847 0.535834405577262 GO:0003697 single-stranded DNA binding 7/681 121/18639 0.0578512396694215 1.58339097826483 0.154589969504937 0.535834405577262 GO:0035091 phosphatidylinositol binding 14/681 284/18639 0.0492957746478873 1.3492275237327 0.158855616027561 0.548557595421016 GO:0016247 channel regulator activity 9/681 168/18639 0.0535714285714286 1.46625235997483 0.162640679989367 0.559532488620136 GO:0010851 cyclase regulator activity 2/681 20/18639 0.1 2.73700440528634 0.164658265310583 0.562277483764289 GO:0016505 peptidase activator activity involved in apoptotic process 2/681 20/18639 0.1 2.73700440528634 0.164658265310583 0.562277483764289 GO:0008238 exopeptidase activity 6/681 102/18639 0.0588235294117647 1.61000259134491 0.169762513274229 0.577568403095346 GO:0030971 receptor tyrosine kinase binding 5/681 81/18639 0.0617283950617284 1.68950889215206 0.174319488608595 0.588906462819438 GO:0001846 opsonin binding 2/681 21/18639 0.0952380952380952 2.60667086217747 0.177824773535613 0.588906462819438 GO:0070182 DNA polymerase binding 2/681 21/18639 0.0952380952380952 2.60667086217747 0.177824773535613 0.588906462819438 GO:0140312 cargo adaptor activity 2/681 21/18639 0.0952380952380952 2.60667086217747 0.177824773535613 0.588906462819438 GO:0015036 disulfide oxidoreductase activity 3/681 40/18639 0.075 2.05275330396476 0.178843611268376 0.588906462819438 GO:0030331 nuclear estrogen receptor binding 3/681 40/18639 0.075 2.05275330396476 0.178843611268376 0.588906462819438 GO:0061791 GTPase motor activity 3/681 40/18639 0.075 2.05275330396476 0.178843611268376 0.588906462819438 GO:0071855 neuropeptide receptor binding 3/681 40/18639 0.075 2.05275330396476 0.178843611268376 0.588906462819438 GO:1990606 membrane scission GTPase motor activity 3/681 40/18639 0.075 2.05275330396476 0.178843611268376 0.588906462819438 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 4/681 61/18639 0.0655737704918033 1.79475698707301 0.183152779654518 0.600949689827281 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 3/681 41/18639 0.0731707317073171 2.00268615020952 0.188094920417875 0.61280394567237 GO:0017080 sodium channel regulator activity 3/681 41/18639 0.0731707317073171 2.00268615020952 0.188094920417875 0.61280394567237 GO:0008093 cytoskeletal anchor activity 2/681 22/18639 0.0909090909090909 2.48818582298759 0.191145414345649 0.618372182549784 GO:0030021 extracellular matrix structural constituent conferring compression resistance 2/681 22/18639 0.0909090909090909 2.48818582298759 0.191145414345649 0.618372182549784 GO:0046906 tetrapyrrole binding 8/681 152/18639 0.0526315789473684 1.44052863436123 0.192990550266077 0.622158347361268 GO:0000295 adenine nucleotide transmembrane transporter activity 2/681 23/18639 0.0869565217391304 2.38000383068378 0.20459140560993 0.657258801297405 GO:0048156 tau protein binding 3/681 43/18639 0.0697674418604651 1.90953795717652 0.206947103978871 0.662518159265692 GO:0004222 metalloendopeptidase activity 6/681 110/18639 0.0545454545454545 1.49291149379255 0.214454636338048 0.681766983468822 GO:0030547 signaling receptor inhibitor activity 3/681 44/18639 0.0681818181818182 1.86613936724069 0.216528062868022 0.681766983468822 GO:0005540 hyaluronic acid binding 2/681 24/18639 0.0833333333333333 2.28083700440529 0.218135856966706 0.681766983468822 GO:0015295 solute:proton symporter activity 2/681 24/18639 0.0833333333333333 2.28083700440529 0.218135856966706 0.681766983468822 GO:0048027 mRNA 5'-UTR binding 2/681 24/18639 0.0833333333333333 2.28083700440529 0.218135856966706 0.681766983468822 GO:0050431 transforming growth factor beta binding 2/681 24/18639 0.0833333333333333 2.28083700440529 0.218135856966706 0.681766983468822 GO:0050699 WW domain binding 2/681 24/18639 0.0833333333333333 2.28083700440529 0.218135856966706 0.681766983468822 GO:0008235 metalloexopeptidase activity 4/681 66/18639 0.0606060606060606 1.65879054865839 0.221080489873607 0.688635850214412 GO:0005200 structural constituent of cytoskeleton 6/681 112/18639 0.0535714285714286 1.46625235997483 0.226215327619055 0.702257683719761 GO:0003924 GTPase activity 15/681 331/18639 0.0453172205438066 1.24033432263732 0.231584755330682 0.716513907432514 GO:0016922 nuclear receptor binding 7/681 137/18639 0.0510948905109489 1.39846940416091 0.235301086344113 0.72350092543186 GO:0004518 nuclease activity 10/681 209/18639 0.0478468899521531 1.30957148578294 0.23541244862208 0.72350092543186 GO:0017124 SH3 domain binding 6/681 115/18639 0.0521739130434783 1.42800229841027 0.244231862501779 0.735728427535373 GO:0004435 phosphatidylinositol phospholipase C activity 2/681 26/18639 0.0769230769230769 2.10538800406642 0.245421445213107 0.735728427535373 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 2/681 26/18639 0.0769230769230769 2.10538800406642 0.245421445213107 0.735728427535373 GO:0015216 purine nucleotide transmembrane transporter activity 2/681 26/18639 0.0769230769230769 2.10538800406642 0.245421445213107 0.735728427535373 GO:0030507 spectrin binding 2/681 26/18639 0.0769230769230769 2.10538800406642 0.245421445213107 0.735728427535373 GO:0070412 R-SMAD binding 2/681 26/18639 0.0769230769230769 2.10538800406642 0.245421445213107 0.735728427535373 GO:0001784 phosphotyrosine residue binding 3/681 47/18639 0.0638297872340425 1.74702408848064 0.245774789241752 0.735728427535373 GO:0043495 protein-membrane adaptor activity 3/681 47/18639 0.0638297872340425 1.74702408848064 0.245774789241752 0.735728427535373 GO:0051213 dioxygenase activity 5/681 93/18639 0.0537634408602151 1.4715077447776 0.252996868439469 0.754896804858221 GO:0032266 phosphatidylinositol-3-phosphate binding 3/681 48/18639 0.0625 1.71062775330396 0.255660731302242 0.760384497615055 GO:0008266 poly(U) RNA binding 2/681 27/18639 0.0740740740740741 2.02741067058248 0.259117388342334 0.765725102729591 GO:0015252 proton channel activity 2/681 27/18639 0.0740740740740741 2.02741067058248 0.259117388342334 0.765725102729591 GO:0019902 phosphatase binding 9/681 190/18639 0.0473684210526316 1.29647577092511 0.26004461424776 0.766010013854423 GO:0019789 SUMO transferase activity 2/681 28/18639 0.0714285714285714 1.9550031466331 0.272821227882755 0.785368094545471 GO:0051019 mitogen-activated protein kinase binding 2/681 28/18639 0.0714285714285714 1.9550031466331 0.272821227882755 0.785368094545471 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 2/681 28/18639 0.0714285714285714 1.9550031466331 0.272821227882755 0.785368094545471 GO:0097718 disordered domain specific binding 2/681 28/18639 0.0714285714285714 1.9550031466331 0.272821227882755 0.785368094545471 GO:0003684 damaged DNA binding 4/681 74/18639 0.0540540540540541 1.47946184069532 0.285315797247912 0.785368094545471 GO:0004181 metallocarboxypeptidase activity 2/681 29/18639 0.0689655172413793 1.88758924502506 0.286514131557576 0.785368094545471 GO:0004629 phospholipase C activity 2/681 29/18639 0.0689655172413793 1.88758924502506 0.286514131557576 0.785368094545471 GO:0051861 glycolipid binding 2/681 29/18639 0.0689655172413793 1.88758924502506 0.286514131557576 0.785368094545471 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 6/681 122/18639 0.0491803278688525 1.34606774030476 0.287731493105866 0.785368094545471 GO:0019003 GDP binding 4/681 75/18639 0.0533333333333333 1.45973568281938 0.293551113013147 0.785368094545471 GO:0044183 protein folding chaperone 4/681 75/18639 0.0533333333333333 1.45973568281938 0.293551113013147 0.785368094545471 GO:0016791 phosphatase activity 12/681 273/18639 0.043956043956044 1.20307885946652 0.29721127273955 0.785368094545471 GO:0001965 G-protein alpha-subunit binding 2/681 30/18639 0.0666666666666667 1.82466960352423 0.300178628790254 0.785368094545471 GO:0008106 alcohol dehydrogenase (NADP+) activity 2/681 30/18639 0.0666666666666667 1.82466960352423 0.300178628790254 0.785368094545471 GO:0008187 poly-pyrimidine tract binding 2/681 30/18639 0.0666666666666667 1.82466960352423 0.300178628790254 0.785368094545471 GO:0015215 nucleotide transmembrane transporter activity 2/681 30/18639 0.0666666666666667 1.82466960352423 0.300178628790254 0.785368094545471 GO:0035925 mRNA 3'-UTR AU-rich region binding 2/681 30/18639 0.0666666666666667 1.82466960352423 0.300178628790254 0.785368094545471 GO:0048019 receptor antagonist activity 2/681 30/18639 0.0666666666666667 1.82466960352423 0.300178628790254 0.785368094545471 GO:0043130 ubiquitin binding 5/681 100/18639 0.05 1.36850220264317 0.302368430802743 0.785368094545471 GO:0016860 intramolecular oxidoreductase activity 3/681 53/18639 0.0566037735849057 1.54924777657718 0.305726576090342 0.785368094545471 GO:1901505 carbohydrate derivative transmembrane transporter activity 3/681 53/18639 0.0566037735849057 1.54924777657718 0.305726576090342 0.785368094545471 GO:0003796 lysozyme activity 1/681 10/18639 0.1 2.73700440528634 0.310849915747407 0.785368094545471 GO:0004382 GDP phosphatase activity 1/681 10/18639 0.1 2.73700440528634 0.310849915747407 0.785368094545471 GO:0004862 cAMP-dependent protein kinase inhibitor activity 1/681 10/18639 0.1 2.73700440528634 0.310849915747407 0.785368094545471 GO:0004935 adrenergic receptor activity 1/681 10/18639 0.1 2.73700440528634 0.310849915747407 0.785368094545471 GO:0004955 prostaglandin receptor activity 1/681 10/18639 0.1 2.73700440528634 0.310849915747407 0.785368094545471 GO:0005522 profilin binding 1/681 10/18639 0.1 2.73700440528634 0.310849915747407 0.785368094545471 GO:0008239 dipeptidyl-peptidase activity 1/681 10/18639 0.1 2.73700440528634 0.310849915747407 0.785368094545471 GO:0015279 store-operated calcium channel activity 1/681 10/18639 0.1 2.73700440528634 0.310849915747407 0.785368094545471 GO:0015643 toxic substance binding 1/681 10/18639 0.1 2.73700440528634 0.310849915747407 0.785368094545471 GO:0015924 mannosyl-oligosaccharide mannosidase activity 1/681 10/18639 0.1 2.73700440528634 0.310849915747407 0.785368094545471 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 1/681 10/18639 0.1 2.73700440528634 0.310849915747407 0.785368094545471 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1/681 10/18639 0.1 2.73700440528634 0.310849915747407 0.785368094545471 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 1/681 10/18639 0.1 2.73700440528634 0.310849915747407 0.785368094545471 GO:0030957 Tat protein binding 1/681 10/18639 0.1 2.73700440528634 0.310849915747407 0.785368094545471 GO:0035374 chondroitin sulfate binding 1/681 10/18639 0.1 2.73700440528634 0.310849915747407 0.785368094545471 GO:0042166 acetylcholine binding 1/681 10/18639 0.1 2.73700440528634 0.310849915747407 0.785368094545471 GO:0043121 neurotrophin binding 1/681 10/18639 0.1 2.73700440528634 0.310849915747407 0.785368094545471 GO:0043208 glycosphingolipid binding 1/681 10/18639 0.1 2.73700440528634 0.310849915747407 0.785368094545471 GO:0047429 nucleoside triphosphate diphosphatase activity 1/681 10/18639 0.1 2.73700440528634 0.310849915747407 0.785368094545471 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 1/681 10/18639 0.1 2.73700440528634 0.310849915747407 0.785368094545471 GO:0070513 death domain binding 1/681 10/18639 0.1 2.73700440528634 0.310849915747407 0.785368094545471 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 1/681 10/18639 0.1 2.73700440528634 0.310849915747407 0.785368094545471 GO:0098505 G-rich strand telomeric DNA binding 1/681 10/18639 0.1 2.73700440528634 0.310849915747407 0.785368094545471 GO:0003925 G protein activity 3/681 54/18639 0.0555555555555556 1.52055800293686 0.315810319107219 0.785368094545471 GO:0051287 NAD binding 3/681 54/18639 0.0555555555555556 1.52055800293686 0.315810319107219 0.785368094545471 GO:0140463 chromatin-protein adaptor activity 3/681 54/18639 0.0555555555555556 1.52055800293686 0.315810319107219 0.785368094545471 GO:0004722 protein serine/threonine phosphatase activity 5/681 103/18639 0.0485436893203883 1.32864291518755 0.323982274826116 0.785368094545471 GO:0005319 lipid transporter activity 8/681 178/18639 0.0449438202247191 1.23011433945454 0.325983639299777 0.785368094545471 GO:0070717 poly-purine tract binding 2/681 32/18639 0.0625 1.71062775330396 0.327358889004303 0.785368094545471 GO:0002162 dystroglycan binding 1/681 11/18639 0.0909090909090909 2.48818582298759 0.33604242245072 0.785368094545471 GO:0004143 ATP-dependent diacylglycerol kinase activity 1/681 11/18639 0.0909090909090909 2.48818582298759 0.33604242245072 0.785368094545471 GO:0004954 prostanoid receptor activity 1/681 11/18639 0.0909090909090909 2.48818582298759 0.33604242245072 0.785368094545471 GO:0005114 type II transforming growth factor beta receptor binding 1/681 11/18639 0.0909090909090909 2.48818582298759 0.33604242245072 0.785368094545471 GO:0005221 intracellularly cyclic nucleotide-activated monoatomic cation channel activity 1/681 11/18639 0.0909090909090909 2.48818582298759 0.33604242245072 0.785368094545471 GO:0008432 JUN kinase binding 1/681 11/18639 0.0909090909090909 2.48818582298759 0.33604242245072 0.785368094545471 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 1/681 11/18639 0.0909090909090909 2.48818582298759 0.33604242245072 0.785368094545471 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 1/681 11/18639 0.0909090909090909 2.48818582298759 0.33604242245072 0.785368094545471 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 1/681 11/18639 0.0909090909090909 2.48818582298759 0.33604242245072 0.785368094545471 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 1/681 11/18639 0.0909090909090909 2.48818582298759 0.33604242245072 0.785368094545471 GO:0019206 nucleoside kinase activity 1/681 11/18639 0.0909090909090909 2.48818582298759 0.33604242245072 0.785368094545471 GO:0031731 CCR6 chemokine receptor binding 1/681 11/18639 0.0909090909090909 2.48818582298759 0.33604242245072 0.785368094545471 GO:0032050 clathrin heavy chain binding 1/681 11/18639 0.0909090909090909 2.48818582298759 0.33604242245072 0.785368094545471 GO:0032794 GTPase activating protein binding 1/681 11/18639 0.0909090909090909 2.48818582298759 0.33604242245072 0.785368094545471 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 1/681 11/18639 0.0909090909090909 2.48818582298759 0.33604242245072 0.785368094545471 GO:0043855 cyclic nucleotide-activated monoatomic ion channel activity 1/681 11/18639 0.0909090909090909 2.48818582298759 0.33604242245072 0.785368094545471 GO:0048185 activin binding 1/681 11/18639 0.0909090909090909 2.48818582298759 0.33604242245072 0.785368094545471 GO:0050998 nitric-oxide synthase binding 1/681 11/18639 0.0909090909090909 2.48818582298759 0.33604242245072 0.785368094545471 GO:0070697 activin receptor binding 1/681 11/18639 0.0909090909090909 2.48818582298759 0.33604242245072 0.785368094545471 GO:0097493 structural molecule activity conferring elasticity 1/681 11/18639 0.0909090909090909 2.48818582298759 0.33604242245072 0.785368094545471 GO:0099528 G protein-coupled neurotransmitter receptor activity 1/681 11/18639 0.0909090909090909 2.48818582298759 0.33604242245072 0.785368094545471 GO:0140031 phosphorylation-dependent protein binding 1/681 11/18639 0.0909090909090909 2.48818582298759 0.33604242245072 0.785368094545471 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 6/681 130/18639 0.0461538461538462 1.26323280243985 0.339197049991049 0.785368094545471 GO:0033192 calmodulin-dependent protein phosphatase activity 4/681 81/18639 0.0493827160493827 1.35160711372165 0.34344623229554 0.785368094545471 GO:0140791 histone H2AXS140 phosphatase activity 4/681 81/18639 0.0493827160493827 1.35160711372165 0.34344623229554 0.785368094545471 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 4/681 81/18639 0.0493827160493827 1.35160711372165 0.34344623229554 0.785368094545471 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 4/681 81/18639 0.0493827160493827 1.35160711372165 0.34344623229554 0.785368094545471 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 4/681 81/18639 0.0493827160493827 1.35160711372165 0.34344623229554 0.785368094545471 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 4/681 81/18639 0.0493827160493827 1.35160711372165 0.34344623229554 0.785368094545471 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 4/681 81/18639 0.0493827160493827 1.35160711372165 0.34344623229554 0.785368094545471 GO:1990439 MAP kinase serine/threonine phosphatase activity 4/681 81/18639 0.0493827160493827 1.35160711372165 0.34344623229554 0.785368094545471 GO:0005516 calmodulin binding 9/681 207/18639 0.0434782608695652 1.19000191534189 0.345182031562278 0.785368094545471 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 4/681 82/18639 0.0487804878048781 1.33512410013968 0.351802999586076 0.785368094545471 GO:0033549 MAP kinase phosphatase activity 4/681 82/18639 0.0487804878048781 1.33512410013968 0.351802999586076 0.785368094545471 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 6/681 132/18639 0.0454545454545455 1.24409291149379 0.352238655473446 0.785368094545471 GO:0008376 acetylgalactosaminyltransferase activity 2/681 34/18639 0.0588235294117647 1.61000259134491 0.354246749794282 0.785368094545471 GO:0015035 protein-disulfide reductase activity 2/681 34/18639 0.0588235294117647 1.61000259134491 0.354246749794282 0.785368094545471 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 4/681 83/18639 0.0481927710843374 1.31903826760788 0.360160661835534 0.785368094545471 GO:0030165 PDZ domain binding 4/681 83/18639 0.0481927710843374 1.31903826760788 0.360160661835534 0.785368094545471 GO:0000340 RNA 7-methylguanosine cap binding 1/681 12/18639 0.0833333333333333 2.28083700440529 0.360315297172163 0.785368094545471 GO:0005025 transforming growth factor beta receptor activity, type I 1/681 12/18639 0.0833333333333333 2.28083700440529 0.360315297172163 0.785368094545471 GO:0005026 transforming growth factor beta receptor activity, type II 1/681 12/18639 0.0833333333333333 2.28083700440529 0.360315297172163 0.785368094545471 GO:0005095 GTPase inhibitor activity 1/681 12/18639 0.0833333333333333 2.28083700440529 0.360315297172163 0.785368094545471 GO:0008179 adenylate cyclase binding 1/681 12/18639 0.0833333333333333 2.28083700440529 0.360315297172163 0.785368094545471 GO:0008504 monoamine transmembrane transporter activity 1/681 12/18639 0.0833333333333333 2.28083700440529 0.360315297172163 0.785368094545471 GO:0010853 cyclase activator activity 1/681 12/18639 0.0833333333333333 2.28083700440529 0.360315297172163 0.785368094545471 GO:0015166 polyol transmembrane transporter activity 1/681 12/18639 0.0833333333333333 2.28083700440529 0.360315297172163 0.785368094545471 GO:0016361 activin receptor activity, type I 1/681 12/18639 0.0833333333333333 2.28083700440529 0.360315297172163 0.785368094545471 GO:0016362 activin receptor activity, type II 1/681 12/18639 0.0833333333333333 2.28083700440529 0.360315297172163 0.785368094545471 GO:0016801 hydrolase activity, acting on ether bonds 1/681 12/18639 0.0833333333333333 2.28083700440529 0.360315297172163 0.785368094545471 GO:0016803 ether hydrolase activity 1/681 12/18639 0.0833333333333333 2.28083700440529 0.360315297172163 0.785368094545471 GO:0017002 activin receptor activity 1/681 12/18639 0.0833333333333333 2.28083700440529 0.360315297172163 0.785368094545471 GO:0035014 phosphatidylinositol 3-kinase regulator activity 1/681 12/18639 0.0833333333333333 2.28083700440529 0.360315297172163 0.785368094545471 GO:0043047 single-stranded telomeric DNA binding 1/681 12/18639 0.0833333333333333 2.28083700440529 0.360315297172163 0.785368094545471 GO:0097677 STAT family protein binding 1/681 12/18639 0.0833333333333333 2.28083700440529 0.360315297172163 0.785368094545471 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 1/681 12/18639 0.0833333333333333 2.28083700440529 0.360315297172163 0.785368094545471 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 1/681 12/18639 0.0833333333333333 2.28083700440529 0.360315297172163 0.785368094545471 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 1/681 12/18639 0.0833333333333333 2.28083700440529 0.360315297172163 0.785368094545471 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 1/681 12/18639 0.0833333333333333 2.28083700440529 0.360315297172163 0.785368094545471 GO:1990459 transferrin receptor binding 1/681 12/18639 0.0833333333333333 2.28083700440529 0.360315297172163 0.785368094545471 GO:0051087 protein-folding chaperone binding 6/681 134/18639 0.0447761194029851 1.22552436057597 0.365318435649334 0.790671809115617 GO:0015459 potassium channel regulator activity 3/681 59/18639 0.0508474576271186 1.39169715523034 0.366178809644651 0.790671809115617 GO:0031593 polyubiquitin modification-dependent protein binding 3/681 59/18639 0.0508474576271186 1.39169715523034 0.366178809644651 0.790671809115617 GO:0045309 protein phosphorylated amino acid binding 3/681 59/18639 0.0508474576271186 1.39169715523034 0.366178809644651 0.790671809115617 GO:0004527 exonuclease activity 4/681 84/18639 0.0476190476190476 1.30333543108874 0.368515379580952 0.791439154062116 GO:0017018 myosin phosphatase activity 4/681 84/18639 0.0476190476190476 1.30333543108874 0.368515379580952 0.791439154062116 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 3/681 60/18639 0.05 1.36850220264317 0.376196575946266 0.791439154062116 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 3/681 60/18639 0.05 1.36850220264317 0.376196575946266 0.791439154062116 GO:0044325 transmembrane transporter binding 6/681 136/18639 0.0441176470588235 1.20750194350868 0.378420991792167 0.791439154062116 GO:0005484 SNAP receptor activity 2/681 36/18639 0.0555555555555556 1.52055800293686 0.380744354988954 0.791439154062116 GO:0045505 dynein intermediate chain binding 2/681 36/18639 0.0555555555555556 1.52055800293686 0.380744354988954 0.791439154062116 GO:0055106 ubiquitin-protein transferase regulator activity 2/681 36/18639 0.0555555555555556 1.52055800293686 0.380744354988954 0.791439154062116 GO:0004465 lipoprotein lipase activity 1/681 13/18639 0.0769230769230769 2.10538800406642 0.383702062761134 0.791439154062116 GO:0005172 vascular endothelial growth factor receptor binding 1/681 13/18639 0.0769230769230769 2.10538800406642 0.383702062761134 0.791439154062116 GO:0019104 DNA N-glycosylase activity 1/681 13/18639 0.0769230769230769 2.10538800406642 0.383702062761134 0.791439154062116 GO:0019855 calcium channel inhibitor activity 1/681 13/18639 0.0769230769230769 2.10538800406642 0.383702062761134 0.791439154062116 GO:0031432 titin binding 1/681 13/18639 0.0769230769230769 2.10538800406642 0.383702062761134 0.791439154062116 GO:0032396 inhibitory MHC class I receptor activity 1/681 13/18639 0.0769230769230769 2.10538800406642 0.383702062761134 0.791439154062116 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 1/681 13/18639 0.0769230769230769 2.10538800406642 0.383702062761134 0.791439154062116 GO:0045159 myosin II binding 1/681 13/18639 0.0769230769230769 2.10538800406642 0.383702062761134 0.791439154062116 GO:0061459 L-arginine transmembrane transporter activity 1/681 13/18639 0.0769230769230769 2.10538800406642 0.383702062761134 0.791439154062116 GO:0070123 transforming growth factor beta receptor activity, type III 1/681 13/18639 0.0769230769230769 2.10538800406642 0.383702062761134 0.791439154062116 GO:0140666 annealing activity 1/681 13/18639 0.0769230769230769 2.10538800406642 0.383702062761134 0.791439154062116 GO:1901338 catecholamine binding 1/681 13/18639 0.0769230769230769 2.10538800406642 0.383702062761134 0.791439154062116 GO:0042805 actinin binding 2/681 37/18639 0.0540540540540541 1.47946184069532 0.39382051937275 0.80033583678358 GO:0004065 arylsulfatase activity 1/681 14/18639 0.0714285714285714 1.9550031466331 0.406235021810831 0.80033583678358 GO:0005161 platelet-derived growth factor receptor binding 1/681 14/18639 0.0714285714285714 1.9550031466331 0.406235021810831 0.80033583678358 GO:0005344 oxygen carrier activity 1/681 14/18639 0.0714285714285714 1.9550031466331 0.406235021810831 0.80033583678358 GO:0005545 1-phosphatidylinositol binding 1/681 14/18639 0.0714285714285714 1.9550031466331 0.406235021810831 0.80033583678358 GO:0008195 phosphatidate phosphatase activity 1/681 14/18639 0.0714285714285714 1.9550031466331 0.406235021810831 0.80033583678358 GO:0008494 translation activator activity 1/681 14/18639 0.0714285714285714 1.9550031466331 0.406235021810831 0.80033583678358 GO:0016530 metallochaperone activity 1/681 14/18639 0.0714285714285714 1.9550031466331 0.406235021810831 0.80033583678358 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 1/681 14/18639 0.0714285714285714 1.9550031466331 0.406235021810831 0.80033583678358 GO:0030983 mismatched DNA binding 1/681 14/18639 0.0714285714285714 1.9550031466331 0.406235021810831 0.80033583678358 GO:0042043 neurexin family protein binding 1/681 14/18639 0.0714285714285714 1.9550031466331 0.406235021810831 0.80033583678358 GO:0046030 inositol trisphosphate phosphatase activity 1/681 14/18639 0.0714285714285714 1.9550031466331 0.406235021810831 0.80033583678358 GO:0061783 peptidoglycan muralytic activity 1/681 14/18639 0.0714285714285714 1.9550031466331 0.406235021810831 0.80033583678358 GO:0098821 BMP receptor activity 1/681 14/18639 0.0714285714285714 1.9550031466331 0.406235021810831 0.80033583678358 GO:0098847 sequence-specific single stranded DNA binding 1/681 14/18639 0.0714285714285714 1.9550031466331 0.406235021810831 0.80033583678358 GO:1901612 cardiolipin binding 1/681 14/18639 0.0714285714285714 1.9550031466331 0.406235021810831 0.80033583678358 GO:1990825 sequence-specific mRNA binding 1/681 14/18639 0.0714285714285714 1.9550031466331 0.406235021810831 0.80033583678358 GO:0000146 microfilament motor activity 2/681 38/18639 0.0526315789473684 1.44052863436123 0.406769353260502 0.80033583678358 GO:0043531 ADP binding 2/681 38/18639 0.0526315789473684 1.44052863436123 0.406769353260502 0.80033583678358 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 4/681 89/18639 0.0449438202247191 1.23011433945454 0.410117262402001 0.80033583678358 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 4/681 89/18639 0.0449438202247191 1.23011433945454 0.410117262402001 0.80033583678358 GO:0004536 DNA nuclease activity 3/681 64/18639 0.046875 1.28297081497797 0.415886093794967 0.80033583678358 GO:0140793 histone H2AXY142 phosphatase activity 4/681 90/18639 0.0444444444444444 1.21644640234949 0.418379188350729 0.80033583678358 GO:0019208 phosphatase regulator activity 5/681 117/18639 0.0427350427350427 1.16966000225912 0.425802289771677 0.80033583678358 GO:0000774 adenyl-nucleotide exchange factor activity 1/681 15/18639 0.0666666666666667 1.82466960352423 0.427945301013346 0.80033583678358 GO:0004089 carbonate dehydratase activity 1/681 15/18639 0.0666666666666667 1.82466960352423 0.427945301013346 0.80033583678358 GO:0004559 alpha-mannosidase activity 1/681 15/18639 0.0666666666666667 1.82466960352423 0.427945301013346 0.80033583678358 GO:0004953 icosanoid receptor activity 1/681 15/18639 0.0666666666666667 1.82466960352423 0.427945301013346 0.80033583678358 GO:0005402 carbohydrate:monoatomic cation symporter activity 1/681 15/18639 0.0666666666666667 1.82466960352423 0.427945301013346 0.80033583678358 GO:0005523 tropomyosin binding 1/681 15/18639 0.0666666666666667 1.82466960352423 0.427945301013346 0.80033583678358 GO:0008242 omega peptidase activity 1/681 15/18639 0.0666666666666667 1.82466960352423 0.427945301013346 0.80033583678358 GO:0010181 FMN binding 1/681 15/18639 0.0666666666666667 1.82466960352423 0.427945301013346 0.80033583678358 GO:0015250 water channel activity 1/681 15/18639 0.0666666666666667 1.82466960352423 0.427945301013346 0.80033583678358 GO:0015556 C4-dicarboxylate transmembrane transporter activity 1/681 15/18639 0.0666666666666667 1.82466960352423 0.427945301013346 0.80033583678358 GO:0015929 hexosaminidase activity 1/681 15/18639 0.0666666666666667 1.82466960352423 0.427945301013346 0.80033583678358 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 1/681 15/18639 0.0666666666666667 1.82466960352423 0.427945301013346 0.80033583678358 GO:0016846 carbon-sulfur lyase activity 1/681 15/18639 0.0666666666666667 1.82466960352423 0.427945301013346 0.80033583678358 GO:0017081 chloride channel regulator activity 1/681 15/18639 0.0666666666666667 1.82466960352423 0.427945301013346 0.80033583678358 GO:0030553 cGMP binding 1/681 15/18639 0.0666666666666667 1.82466960352423 0.427945301013346 0.80033583678358 GO:0031386 protein tag activity 1/681 15/18639 0.0666666666666667 1.82466960352423 0.427945301013346 0.80033583678358 GO:0033130 acetylcholine receptor binding 1/681 15/18639 0.0666666666666667 1.82466960352423 0.427945301013346 0.80033583678358 GO:0047372 monoacylglycerol lipase activity 1/681 15/18639 0.0666666666666667 1.82466960352423 0.427945301013346 0.80033583678358 GO:0051371 muscle alpha-actinin binding 1/681 15/18639 0.0666666666666667 1.82466960352423 0.427945301013346 0.80033583678358 GO:0061578 K63-linked deubiquitinase activity 1/681 15/18639 0.0666666666666667 1.82466960352423 0.427945301013346 0.80033583678358 GO:0120283 protein serine/threonine kinase binding 1/681 15/18639 0.0666666666666667 1.82466960352423 0.427945301013346 0.80033583678358 GO:0141047 molecular tag activity 1/681 15/18639 0.0666666666666667 1.82466960352423 0.427945301013346 0.80033583678358 GO:0015144 carbohydrate transmembrane transporter activity 2/681 40/18639 0.05 1.36850220264317 0.432253182507742 0.802037961589534 GO:0071949 FAD binding 2/681 40/18639 0.05 1.36850220264317 0.432253182507742 0.802037961589534 GO:0140662 ATP-dependent protein folding chaperone 2/681 40/18639 0.05 1.36850220264317 0.432253182507742 0.802037961589534 GO:0051219 phosphoprotein binding 4/681 93/18639 0.043010752688172 1.17720619582208 0.442990636369854 0.802037961589534 GO:0001727 lipid kinase activity 2/681 41/18639 0.0487804878048781 1.33512410013968 0.444774119025171 0.802037961589534 GO:0008227 G protein-coupled amine receptor activity 2/681 41/18639 0.0487804878048781 1.33512410013968 0.444774119025171 0.802037961589534 GO:0042169 SH2 domain binding 2/681 41/18639 0.0487804878048781 1.33512410013968 0.444774119025171 0.802037961589534 GO:0061650 ubiquitin-like protein conjugating enzyme activity 2/681 41/18639 0.0487804878048781 1.33512410013968 0.444774119025171 0.802037961589534 GO:0003712 transcription coregulator activity 19/681 495/18639 0.0383838383838384 1.05056734748365 0.445951234397703 0.802037961589534 GO:0140030 modification-dependent protein binding 7/681 173/18639 0.0404624277456647 1.10745842988465 0.446235455375858 0.802037961589534 GO:0032182 ubiquitin-like protein binding 5/681 120/18639 0.0416666666666667 1.14041850220264 0.447399392841395 0.802037961589534 GO:0016829 lyase activity 8/681 200/18639 0.04 1.09480176211454 0.448025528494783 0.802037961589534 GO:0005024 transforming growth factor beta receptor activity 1/681 16/18639 0.0625 1.71062775330396 0.448862893904772 0.802037961589534 GO:0005324 long-chain fatty acid transmembrane transporter activity 1/681 16/18639 0.0625 1.71062775330396 0.448862893904772 0.802037961589534 GO:0005521 lamin binding 1/681 16/18639 0.0625 1.71062775330396 0.448862893904772 0.802037961589534 GO:0008142 oxysterol binding 1/681 16/18639 0.0625 1.71062775330396 0.448862893904772 0.802037961589534 GO:0008296 3'-5'-DNA exonuclease activity 1/681 16/18639 0.0625 1.71062775330396 0.448862893904772 0.802037961589534 GO:0015378 sodium:chloride symporter activity 1/681 16/18639 0.0625 1.71062775330396 0.448862893904772 0.802037961589534 GO:0015923 mannosidase activity 1/681 16/18639 0.0625 1.71062775330396 0.448862893904772 0.802037961589534 GO:0016722 oxidoreductase activity, acting on metal ions 1/681 16/18639 0.0625 1.71062775330396 0.448862893904772 0.802037961589534 GO:0019841 retinol binding 1/681 16/18639 0.0625 1.71062775330396 0.448862893904772 0.802037961589534 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity 1/681 16/18639 0.0625 1.71062775330396 0.448862893904772 0.802037961589534 GO:0070411 I-SMAD binding 1/681 16/18639 0.0625 1.71062775330396 0.448862893904772 0.802037961589534 GO:0004540 RNA nuclease activity 5/681 121/18639 0.0413223140495868 1.13099355590345 0.45455406935203 0.808987787855731 GO:1990841 promoter-specific chromatin binding 3/681 68/18639 0.0441176470588235 1.20750194350868 0.454725748889758 0.808987787855731 GO:0004402 histone acetyltransferase activity 2/681 42/18639 0.0476190476190476 1.30333543108874 0.457139520035614 0.808987787855731 GO:0008307 structural constituent of muscle 2/681 42/18639 0.0476190476190476 1.30333543108874 0.457139520035614 0.808987787855731 GO:0035198 miRNA binding 2/681 42/18639 0.0476190476190476 1.30333543108874 0.457139520035614 0.808987787855731 GO:0002039 p53 binding 3/681 69/18639 0.0434782608695652 1.19000191534189 0.464269900824812 0.809800373217478 GO:0004029 aldehyde dehydrogenase (NAD+) activity 1/681 17/18639 0.0588235294117647 1.61000259134491 0.469016702058713 0.809800373217478 GO:0004549 tRNA-specific ribonuclease activity 1/681 17/18639 0.0588235294117647 1.61000259134491 0.469016702058713 0.809800373217478 GO:0004550 nucleoside diphosphate kinase activity 1/681 17/18639 0.0588235294117647 1.61000259134491 0.469016702058713 0.809800373217478 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 1/681 17/18639 0.0588235294117647 1.61000259134491 0.469016702058713 0.809800373217478 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 1/681 17/18639 0.0588235294117647 1.61000259134491 0.469016702058713 0.809800373217478 GO:0005092 GDP-dissociation inhibitor activity 1/681 17/18639 0.0588235294117647 1.61000259134491 0.469016702058713 0.809800373217478 GO:0008484 sulfuric ester hydrolase activity 1/681 17/18639 0.0588235294117647 1.61000259134491 0.469016702058713 0.809800373217478 GO:0019198 transmembrane receptor protein phosphatase activity 1/681 17/18639 0.0588235294117647 1.61000259134491 0.469016702058713 0.809800373217478 GO:0030548 acetylcholine receptor regulator activity 1/681 17/18639 0.0588235294117647 1.61000259134491 0.469016702058713 0.809800373217478 GO:0046965 nuclear retinoid X receptor binding 1/681 17/18639 0.0588235294117647 1.61000259134491 0.469016702058713 0.809800373217478 GO:0051787 misfolded protein binding 1/681 17/18639 0.0588235294117647 1.61000259134491 0.469016702058713 0.809800373217478 GO:0070492 oligosaccharide binding 1/681 17/18639 0.0588235294117647 1.61000259134491 0.469016702058713 0.809800373217478 GO:0008028 monocarboxylic acid transmembrane transporter activity 3/681 70/18639 0.0428571428571429 1.17300188797986 0.473740089206905 0.816426845324796 GO:0019205 nucleobase-containing compound kinase activity 2/681 44/18639 0.0454545454545455 1.24409291149379 0.481382883624891 0.817767064469516 GO:0030020 extracellular matrix structural constituent conferring tensile strength 2/681 44/18639 0.0454545454545455 1.24409291149379 0.481382883624891 0.817767064469516 GO:0004725 protein tyrosine phosphatase activity 4/681 98/18639 0.0408163265306122 1.11714465521892 0.483258637959729 0.817767064469516 GO:0042626 ATPase-coupled transmembrane transporter activity 4/681 98/18639 0.0408163265306122 1.11714465521892 0.483258637959729 0.817767064469516 GO:0000400 four-way junction DNA binding 1/681 18/18639 0.0555555555555556 1.52055800293686 0.488434574784414 0.817767064469516 GO:0000900 mRNA regulatory element binding translation repressor activity 1/681 18/18639 0.0555555555555556 1.52055800293686 0.488434574784414 0.817767064469516 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 1/681 18/18639 0.0555555555555556 1.52055800293686 0.488434574784414 0.817767064469516 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 1/681 18/18639 0.0555555555555556 1.52055800293686 0.488434574784414 0.817767064469516 GO:0005372 water transmembrane transporter activity 1/681 18/18639 0.0555555555555556 1.52055800293686 0.488434574784414 0.817767064469516 GO:0015373 monoatomic anion:sodium symporter activity 1/681 18/18639 0.0555555555555556 1.52055800293686 0.488434574784414 0.817767064469516 GO:0017128 phospholipid scramblase activity 1/681 18/18639 0.0555555555555556 1.52055800293686 0.488434574784414 0.817767064469516 GO:0031690 adrenergic receptor binding 1/681 18/18639 0.0555555555555556 1.52055800293686 0.488434574784414 0.817767064469516 GO:0032393 MHC class I receptor activity 1/681 18/18639 0.0555555555555556 1.52055800293686 0.488434574784414 0.817767064469516 GO:0099602 neurotransmitter receptor regulator activity 1/681 18/18639 0.0555555555555556 1.52055800293686 0.488434574784414 0.817767064469516 GO:1901611 phosphatidylglycerol binding 1/681 18/18639 0.0555555555555556 1.52055800293686 0.488434574784414 0.817767064469516 GO:0003774 cytoskeletal motor activity 6/681 153/18639 0.0392156862745098 1.07333506089661 0.488708950675383 0.817767064469516 GO:0046915 transition metal ion transmembrane transporter activity 2/681 45/18639 0.0444444444444444 1.21644640234949 0.493251888092659 0.823873624676506 GO:0004521 RNA endonuclease activity 3/681 73/18639 0.0410958904109589 1.12479633093959 0.501673391920112 0.830526050244755 GO:0043539 protein serine/threonine kinase activator activity 3/681 73/18639 0.0410958904109589 1.12479633093959 0.501673391920112 0.830526050244755 GO:0030276 clathrin binding 2/681 46/18639 0.0434782608695652 1.19000191534189 0.504947369866842 0.830526050244755 GO:0003756 protein disulfide isomerase activity 1/681 19/18639 0.0526315789473684 1.44052863436123 0.507143347383728 0.830526050244755 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 1/681 19/18639 0.0526315789473684 1.44052863436123 0.507143347383728 0.830526050244755 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 1/681 19/18639 0.0526315789473684 1.44052863436123 0.507143347383728 0.830526050244755 GO:0016918 retinal binding 1/681 19/18639 0.0526315789473684 1.44052863436123 0.507143347383728 0.830526050244755 GO:0030506 ankyrin binding 1/681 19/18639 0.0526315789473684 1.44052863436123 0.507143347383728 0.830526050244755 GO:0042834 peptidoglycan binding 1/681 19/18639 0.0526315789473684 1.44052863436123 0.507143347383728 0.830526050244755 GO:0097001 ceramide binding 1/681 19/18639 0.0526315789473684 1.44052863436123 0.507143347383728 0.830526050244755 GO:0140036 ubiquitin-modified protein reader activity 1/681 19/18639 0.0526315789473684 1.44052863436123 0.507143347383728 0.830526050244755 GO:0035064 methylated histone binding 3/681 74/18639 0.0405405405405405 1.10959638052149 0.510815262117529 0.833578179951083 GO:0048029 monosaccharide binding 3/681 74/18639 0.0405405405405405 1.10959638052149 0.510815262117529 0.833578179951083 GO:0061733 protein-lysine-acetyltransferase activity 2/681 47/18639 0.0425531914893617 1.16468272565376 0.516466151227956 0.83917799919179 GO:0031072 heat shock protein binding 5/681 131/18639 0.0381679389312977 1.04465816995662 0.524400571802815 0.83917799919179 GO:0000339 RNA cap binding 1/681 20/18639 0.05 1.36850220264317 0.525168878019157 0.83917799919179 GO:0001614 purinergic nucleotide receptor activity 1/681 20/18639 0.05 1.36850220264317 0.525168878019157 0.83917799919179 GO:0005326 neurotransmitter transmembrane transporter activity 1/681 20/18639 0.05 1.36850220264317 0.525168878019157 0.83917799919179 GO:0015464 acetylcholine receptor activity 1/681 20/18639 0.05 1.36850220264317 0.525168878019157 0.83917799919179 GO:0016502 nucleotide receptor activity 1/681 20/18639 0.05 1.36850220264317 0.525168878019157 0.83917799919179 GO:0030742 GTP-dependent protein binding 1/681 20/18639 0.05 1.36850220264317 0.525168878019157 0.83917799919179 GO:0031418 L-ascorbic acid binding 1/681 20/18639 0.05 1.36850220264317 0.525168878019157 0.83917799919179 GO:0042288 MHC class I protein binding 1/681 20/18639 0.05 1.36850220264317 0.525168878019157 0.83917799919179 GO:0043024 ribosomal small subunit binding 1/681 20/18639 0.05 1.36850220264317 0.525168878019157 0.83917799919179 GO:0052745 inositol phosphate phosphatase activity 1/681 20/18639 0.05 1.36850220264317 0.525168878019157 0.83917799919179 GO:0001216 DNA-binding transcription activator activity 18/681 491/18639 0.0366598778004073 1.00338247036974 0.528464239298274 0.842107575226025 GO:0140034 methylation-dependent protein binding 3/681 76/18639 0.0394736842105263 1.08039647577093 0.528828943661463 0.842107575226025 GO:0051540 metal cluster binding 3/681 77/18639 0.038961038961039 1.06636535270897 0.537696001669491 0.843538395869062 GO:0016763 pentosyltransferase activity 2/681 49/18639 0.0408163265306122 1.11714465521892 0.538963186618614 0.843538395869062 GO:0060590 ATPase regulator activity 2/681 49/18639 0.0408163265306122 1.11714465521892 0.538963186618614 0.843538395869062 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 1/681 21/18639 0.0476190476190476 1.30333543108874 0.542536083243334 0.843538395869062 GO:0005123 death receptor binding 1/681 21/18639 0.0476190476190476 1.30333543108874 0.542536083243334 0.843538395869062 GO:0010314 phosphatidylinositol-5-phosphate binding 1/681 21/18639 0.0476190476190476 1.30333543108874 0.542536083243334 0.843538395869062 GO:0015125 bile acid transmembrane transporter activity 1/681 21/18639 0.0476190476190476 1.30333543108874 0.542536083243334 0.843538395869062 GO:0015174 basic amino acid transmembrane transporter activity 1/681 21/18639 0.0476190476190476 1.30333543108874 0.542536083243334 0.843538395869062 GO:0019200 carbohydrate kinase activity 1/681 21/18639 0.0476190476190476 1.30333543108874 0.542536083243334 0.843538395869062 GO:0035613 RNA stem-loop binding 1/681 21/18639 0.0476190476190476 1.30333543108874 0.542536083243334 0.843538395869062 GO:0051010 microtubule plus-end binding 1/681 21/18639 0.0476190476190476 1.30333543108874 0.542536083243334 0.843538395869062 GO:0051428 peptide hormone receptor binding 1/681 21/18639 0.0476190476190476 1.30333543108874 0.542536083243334 0.843538395869062 GO:0061891 calcium ion sensor activity 1/681 21/18639 0.0476190476190476 1.30333543108874 0.542536083243334 0.843538395869062 GO:0072542 protein phosphatase activator activity 1/681 21/18639 0.0476190476190476 1.30333543108874 0.542536083243334 0.843538395869062 GO:0008013 beta-catenin binding 4/681 106/18639 0.0377358490566038 1.03283185105145 0.545067296558871 0.846047217891042 GO:0015605 organophosphate ester transmembrane transporter activity 2/681 50/18639 0.04 1.09480176211454 0.54993728305584 0.852171722651235 GO:0019888 protein phosphatase regulator activity 4/681 107/18639 0.0373831775700935 1.02317921692947 0.552524780126621 0.85371853046997 GO:0019838 growth factor binding 5/681 136/18639 0.0367647058823529 1.00625161959057 0.557842890511985 0.85371853046997 GO:0140789 histone phosphatase activity 5/681 136/18639 0.0367647058823529 1.00625161959057 0.557842890511985 0.85371853046997 GO:0008970 phospholipase A1 activity 1/681 22/18639 0.0454545454545455 1.24409291149379 0.559268972238462 0.85371853046997 GO:0015377 chloride:monoatomic cation symporter activity 1/681 22/18639 0.0454545454545455 1.24409291149379 0.559268972238462 0.85371853046997 GO:0061133 endopeptidase activator activity 1/681 22/18639 0.0454545454545455 1.24409291149379 0.559268972238462 0.85371853046997 GO:0140035 ubiquitin-like protein reader activity 1/681 22/18639 0.0454545454545455 1.24409291149379 0.559268972238462 0.85371853046997 GO:0140517 protein-RNA adaptor activity 1/681 22/18639 0.0454545454545455 1.24409291149379 0.559268972238462 0.85371853046997 GO:0140784 metal ion sensor activity 1/681 22/18639 0.0454545454545455 1.24409291149379 0.559268972238462 0.85371853046997 GO:0003743 translation initiation factor activity 2/681 51/18639 0.0392156862745098 1.07333506089661 0.560726309438061 0.854528359176681 GO:0015101 organic cation transmembrane transporter activity 3/681 81/18639 0.037037037037037 1.01370533529124 0.572185004239135 0.861217868160896 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 1/681 23/18639 0.0434782608695652 1.19000191534189 0.575390679812486 0.861217868160896 GO:0004022 alcohol dehydrogenase (NAD+) activity 1/681 23/18639 0.0434782608695652 1.19000191534189 0.575390679812486 0.861217868160896 GO:0005158 insulin receptor binding 1/681 23/18639 0.0434782608695652 1.19000191534189 0.575390679812486 0.861217868160896 GO:0005212 structural constituent of eye lens 1/681 23/18639 0.0434782608695652 1.19000191534189 0.575390679812486 0.861217868160896 GO:0031681 G-protein beta-subunit binding 1/681 23/18639 0.0434782608695652 1.19000191534189 0.575390679812486 0.861217868160896 GO:0042171 lysophosphatidic acid acyltransferase activity 1/681 23/18639 0.0434782608695652 1.19000191534189 0.575390679812486 0.861217868160896 GO:0043274 phospholipase binding 1/681 23/18639 0.0434782608695652 1.19000191534189 0.575390679812486 0.861217868160896 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 1/681 23/18639 0.0434782608695652 1.19000191534189 0.575390679812486 0.861217868160896 GO:0071617 lysophospholipid acyltransferase activity 1/681 23/18639 0.0434782608695652 1.19000191534189 0.575390679812486 0.861217868160896 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 1/681 23/18639 0.0434782608695652 1.19000191534189 0.575390679812486 0.861217868160896 GO:0005246 calcium channel regulator activity 2/681 53/18639 0.0377358490566038 1.03283185105145 0.581744908508112 0.862082674214553 GO:0017046 peptide hormone binding 2/681 53/18639 0.0377358490566038 1.03283185105145 0.581744908508112 0.862082674214553 GO:0034212 protein N-acetyltransferase activity 2/681 53/18639 0.0377358490566038 1.03283185105145 0.581744908508112 0.862082674214553 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 1/681 24/18639 0.0416666666666667 1.14041850220264 0.590923498197085 0.862082674214553 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 1/681 24/18639 0.0416666666666667 1.14041850220264 0.590923498197085 0.862082674214553 GO:0004622 lysophospholipase activity 1/681 24/18639 0.0416666666666667 1.14041850220264 0.590923498197085 0.862082674214553 GO:0004806 triacylglycerol lipase activity 1/681 24/18639 0.0416666666666667 1.14041850220264 0.590923498197085 0.862082674214553 GO:0015149 hexose transmembrane transporter activity 1/681 24/18639 0.0416666666666667 1.14041850220264 0.590923498197085 0.862082674214553 GO:0030215 semaphorin receptor binding 1/681 24/18639 0.0416666666666667 1.14041850220264 0.590923498197085 0.862082674214553 GO:0030552 cAMP binding 1/681 24/18639 0.0416666666666667 1.14041850220264 0.590923498197085 0.862082674214553 GO:0035035 histone acetyltransferase binding 1/681 24/18639 0.0416666666666667 1.14041850220264 0.590923498197085 0.862082674214553 GO:0055056 D-glucose transmembrane transporter activity 1/681 24/18639 0.0416666666666667 1.14041850220264 0.590923498197085 0.862082674214553 GO:0070300 phosphatidic acid binding 1/681 24/18639 0.0416666666666667 1.14041850220264 0.590923498197085 0.862082674214553 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 1/681 24/18639 0.0416666666666667 1.14041850220264 0.590923498197085 0.862082674214553 GO:0003713 transcription coactivator activity 9/681 256/18639 0.03515625 0.96222811123348 0.594252643285594 0.862082674214553 GO:0051117 ATPase binding 3/681 84/18639 0.0357142857142857 0.977501573316551 0.596978070932004 0.862082674214553 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 17/681 484/18639 0.0351239669421488 0.961344522517931 0.601397464440779 0.862082674214553 GO:0008374 O-acyltransferase activity 2/681 55/18639 0.0363636363636364 0.995274329195034 0.60201366298748 0.862082674214553 GO:0019001 guanyl nucleotide binding 14/681 400/18639 0.035 0.95795154185022 0.603791451173471 0.862082674214553 GO:0032561 guanyl ribonucleotide binding 14/681 400/18639 0.035 0.95795154185022 0.603791451173471 0.862082674214553 GO:0003707 nuclear steroid receptor activity 1/681 25/18639 0.04 1.09480176211454 0.605888907690922 0.862082674214553 GO:0008139 nuclear localization sequence binding 1/681 25/18639 0.04 1.09480176211454 0.605888907690922 0.862082674214553 GO:0015296 monoatomic anion:monoatomic cation symporter activity 1/681 25/18639 0.04 1.09480176211454 0.605888907690922 0.862082674214553 GO:0015645 fatty acid ligase activity 1/681 25/18639 0.04 1.09480176211454 0.605888907690922 0.862082674214553 GO:0015662 P-type ion transporter activity 1/681 25/18639 0.04 1.09480176211454 0.605888907690922 0.862082674214553 GO:0019211 phosphatase activator activity 1/681 25/18639 0.04 1.09480176211454 0.605888907690922 0.862082674214553 GO:0019706 protein-cysteine S-palmitoyltransferase activity 1/681 25/18639 0.04 1.09480176211454 0.605888907690922 0.862082674214553 GO:0019707 protein-cysteine S-acyltransferase activity 1/681 25/18639 0.04 1.09480176211454 0.605888907690922 0.862082674214553 GO:0042974 nuclear retinoic acid receptor binding 1/681 25/18639 0.04 1.09480176211454 0.605888907690922 0.862082674214553 GO:0120020 cholesterol transfer activity 1/681 25/18639 0.04 1.09480176211454 0.605888907690922 0.862082674214553 GO:0120515 fatty acid-CoA ligase activity 1/681 25/18639 0.04 1.09480176211454 0.605888907690922 0.862082674214553 GO:0140358 P-type transmembrane transporter activity 1/681 25/18639 0.04 1.09480176211454 0.605888907690922 0.862082674214553 GO:0019903 protein phosphatase binding 5/681 144/18639 0.0347222222222222 0.950348751835536 0.608785673083779 0.862629883721285 GO:0001221 transcription coregulator binding 4/681 115/18639 0.0347826086956522 0.952001532273511 0.609731115261558 0.862629883721285 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 2/681 56/18639 0.0357142857142857 0.977501573316551 0.611866457917134 0.862629883721285 GO:0015294 solute:monoatomic cation symporter activity 4/681 116/18639 0.0344827586206897 0.943794622512532 0.616558446992821 0.862629883721285 GO:0004721 phosphoprotein phosphatase activity 6/681 175/18639 0.0342857142857143 0.938401510383889 0.620182390616829 0.862629883721285 GO:0004112 cyclic-nucleotide phosphodiesterase activity 1/681 26/18639 0.0384615384615385 1.05269400203321 0.620307606190035 0.862629883721285 GO:0005112 Notch binding 1/681 26/18639 0.0384615384615385 1.05269400203321 0.620307606190035 0.862629883721285 GO:0005160 transforming growth factor beta receptor binding 1/681 26/18639 0.0384615384615385 1.05269400203321 0.620307606190035 0.862629883721285 GO:0008143 poly(A) binding 1/681 26/18639 0.0384615384615385 1.05269400203321 0.620307606190035 0.862629883721285 GO:0008157 protein phosphatase 1 binding 1/681 26/18639 0.0384615384615385 1.05269400203321 0.620307606190035 0.862629883721285 GO:0015145 monosaccharide transmembrane transporter activity 1/681 26/18639 0.0384615384615385 1.05269400203321 0.620307606190035 0.862629883721285 GO:0034237 protein kinase A regulatory subunit binding 1/681 26/18639 0.0384615384615385 1.05269400203321 0.620307606190035 0.862629883721285 GO:0050681 nuclear androgen receptor binding 1/681 26/18639 0.0384615384615385 1.05269400203321 0.620307606190035 0.862629883721285 GO:0051139 metal cation:proton antiporter activity 1/681 26/18639 0.0384615384615385 1.05269400203321 0.620307606190035 0.862629883721285 GO:0052742 phosphatidylinositol kinase activity 1/681 26/18639 0.0384615384615385 1.05269400203321 0.620307606190035 0.862629883721285 GO:0015932 nucleobase-containing compound transmembrane transporter activity 2/681 57/18639 0.0350877192982456 0.960352422907489 0.621531839926643 0.863030657247537 GO:0005525 GTP binding 13/681 378/18639 0.0343915343915344 0.941297811341864 0.627952502654975 0.870634898417875 GO:0008408 3'-5' exonuclease activity 2/681 58/18639 0.0344827586206897 0.943794622512532 0.631010331059215 0.871433641891729 GO:0061980 regulatory RNA binding 2/681 58/18639 0.0344827586206897 0.943794622512532 0.631010331059215 0.871433641891729 GO:0001671 ATPase activator activity 1/681 27/18639 0.037037037037037 1.01370533529124 0.634199537645716 0.871433641891729 GO:0005104 fibroblast growth factor receptor binding 1/681 27/18639 0.037037037037037 1.01370533529124 0.634199537645716 0.871433641891729 GO:0008395 steroid hydroxylase activity 1/681 27/18639 0.037037037037037 1.01370533529124 0.634199537645716 0.871433641891729 GO:0016405 CoA-ligase activity 1/681 27/18639 0.037037037037037 1.01370533529124 0.634199537645716 0.871433641891729 GO:0004879 nuclear receptor activity 2/681 59/18639 0.0338983050847458 0.927798103486896 0.640302665143937 0.877205137091694 GO:0070063 RNA polymerase binding 2/681 59/18639 0.0338983050847458 0.927798103486896 0.640302665143937 0.877205137091694 GO:0016853 isomerase activity 6/681 180/18639 0.0333333333333333 0.912334801762114 0.647268109341318 0.878047608483328 GO:0036408 histone H3K14 acetyltransferase activity 1/681 28/18639 0.0357142857142857 0.977501573316551 0.647583919488788 0.878047608483328 GO:0046625 sphingolipid binding 1/681 28/18639 0.0357142857142857 0.977501573316551 0.647583919488788 0.878047608483328 GO:0046875 ephrin receptor binding 1/681 28/18639 0.0357142857142857 0.977501573316551 0.647583919488788 0.878047608483328 GO:0051119 sugar transmembrane transporter activity 1/681 28/18639 0.0357142857142857 0.977501573316551 0.647583919488788 0.878047608483328 GO:0051393 alpha-actinin binding 1/681 28/18639 0.0357142857142857 0.977501573316551 0.647583919488788 0.878047608483328 GO:0051537 2 iron, 2 sulfur cluster binding 1/681 28/18639 0.0357142857142857 0.977501573316551 0.647583919488788 0.878047608483328 GO:0098531 ligand-modulated transcription factor activity 2/681 60/18639 0.0333333333333333 0.912334801762114 0.649409771667995 0.878142074705922 GO:0051082 unfolded protein binding 4/681 121/18639 0.0330578512396694 0.904794844722758 0.649558454392016 0.878142074705922 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 3/681 91/18639 0.032967032967033 0.902309144599894 0.65107206799313 0.878899629121034 GO:0010484 histone H3 acetyltransferase activity 1/681 29/18639 0.0344827586206897 0.943794622512532 0.66047926905776 0.88899545411862 GO:0016417 S-acyltransferase activity 1/681 29/18639 0.0344827586206897 0.943794622512532 0.66047926905776 0.88899545411862 GO:0042562 hormone binding 3/681 94/18639 0.0319148936170213 0.873512044240322 0.67260912323794 0.895262570851024 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 1/681 30/18639 0.0333333333333333 0.912334801762114 0.672903429066985 0.895262570851024 GO:0031210 phosphatidylcholine binding 1/681 30/18639 0.0333333333333333 0.912334801762114 0.672903429066985 0.895262570851024 GO:0033612 receptor serine/threonine kinase binding 1/681 30/18639 0.0333333333333333 0.912334801762114 0.672903429066985 0.895262570851024 GO:0043995 histone H4K5 acetyltransferase activity 1/681 30/18639 0.0333333333333333 0.912334801762114 0.672903429066985 0.895262570851024 GO:0043996 histone H4K8 acetyltransferase activity 1/681 30/18639 0.0333333333333333 0.912334801762114 0.672903429066985 0.895262570851024 GO:0043997 histone H4K12 acetyltransferase activity 1/681 30/18639 0.0333333333333333 0.912334801762114 0.672903429066985 0.895262570851024 GO:0051721 protein phosphatase 2A binding 1/681 30/18639 0.0333333333333333 0.912334801762114 0.672903429066985 0.895262570851024 GO:1901682 sulfur compound transmembrane transporter activity 2/681 63/18639 0.0317460317460317 0.86889028739249 0.675631641589414 0.897597080036657 GO:0005184 neuropeptide hormone activity 1/681 31/18639 0.032258064516129 0.882904646866562 0.684873592149653 0.902076359945686 GO:0005310 dicarboxylic acid transmembrane transporter activity 1/681 31/18639 0.032258064516129 0.882904646866562 0.684873592149653 0.902076359945686 GO:0016411 acylglycerol O-acyltransferase activity 1/681 31/18639 0.032258064516129 0.882904646866562 0.684873592149653 0.902076359945686 GO:0016878 acid-thiol ligase activity 1/681 31/18639 0.032258064516129 0.882904646866562 0.684873592149653 0.902076359945686 GO:0047499 calcium-independent phospholipase A2 activity 1/681 31/18639 0.032258064516129 0.882904646866562 0.684873592149653 0.902076359945686 GO:0072349 modified amino acid transmembrane transporter activity 1/681 31/18639 0.032258064516129 0.882904646866562 0.684873592149653 0.902076359945686 GO:0004519 endonuclease activity 4/681 127/18639 0.031496062992126 0.86204863158625 0.68659226996026 0.903050032672411 GO:0001217 DNA-binding transcription repressor activity 9/681 278/18639 0.0323741007194245 0.886080562862485 0.690735991449963 0.904347367883753 GO:0120013 lipid transfer activity 2/681 65/18639 0.0307692307692308 0.842155201626567 0.692211269255746 0.904347367883753 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 4/681 128/18639 0.03125 0.855313876651982 0.692488170705916 0.904347367883753 GO:0022884 macromolecule transmembrane transporter activity 1/681 32/18639 0.03125 0.855313876651982 0.696406324509181 0.904347367883753 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1/681 32/18639 0.03125 0.855313876651982 0.696406324509181 0.904347367883753 GO:0042910 xenobiotic transmembrane transporter activity 1/681 32/18639 0.03125 0.855313876651982 0.696406324509181 0.904347367883753 GO:0043425 bHLH transcription factor binding 1/681 32/18639 0.03125 0.855313876651982 0.696406324509181 0.904347367883753 GO:0120015 sterol transfer activity 1/681 32/18639 0.03125 0.855313876651982 0.696406324509181 0.904347367883753 GO:0160041 neuropeptide activity 1/681 32/18639 0.03125 0.855313876651982 0.696406324509181 0.904347367883753 GO:0016798 hydrolase activity, acting on glycosyl bonds 4/681 130/18639 0.0307692307692308 0.842155201626567 0.70404204955175 0.912977172555152 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 1/681 33/18639 0.0303030303030303 0.829395274329195 0.707517588711322 0.913629155170643 GO:0042923 neuropeptide binding 1/681 33/18639 0.0303030303030303 0.829395274329195 0.707517588711322 0.913629155170643 GO:0140416 transcription regulator inhibitor activity 1/681 33/18639 0.0303030303030303 0.829395274329195 0.707517588711322 0.913629155170643 GO:0005262 calcium channel activity 4/681 131/18639 0.0305343511450382 0.835726535965296 0.709700048850928 0.914982333557534 GO:0031267 small GTPase binding 9/681 283/18639 0.0318021201413428 0.870425429243007 0.710550272046849 0.914982333557534 GO:0032934 sterol binding 2/681 68/18639 0.0294117647058824 0.805001295672454 0.715763223979421 0.918448529719338 GO:0008236 serine-type peptidase activity 6/681 194/18639 0.0309278350515464 0.846496207820519 0.716587921087219 0.918448529719338 GO:0019825 oxygen binding 1/681 34/18639 0.0294117647058824 0.805001295672454 0.718222765648202 0.918448529719338 GO:0030332 cyclin binding 1/681 34/18639 0.0294117647058824 0.805001295672454 0.718222765648202 0.918448529719338 GO:0090482 vitamin transmembrane transporter activity 1/681 34/18639 0.0294117647058824 0.805001295672454 0.718222765648202 0.918448529719338 GO:0008080 N-acetyltransferase activity 2/681 69/18639 0.0289855072463768 0.793334610227926 0.723270487357171 0.920151801368984 GO:0098960 postsynaptic neurotransmitter receptor activity 2/681 69/18639 0.0289855072463768 0.793334610227926 0.723270487357171 0.920151801368984 GO:0004623 phospholipase A2 activity 1/681 35/18639 0.0285714285714286 0.782001258653241 0.728536675704293 0.920151801368984 GO:0005343 organic acid:sodium symporter activity 1/681 35/18639 0.0285714285714286 0.782001258653241 0.728536675704293 0.920151801368984 GO:0010485 histone H4 acetyltransferase activity 1/681 35/18639 0.0285714285714286 0.782001258653241 0.728536675704293 0.920151801368984 GO:0016229 steroid dehydrogenase activity 1/681 35/18639 0.0285714285714286 0.782001258653241 0.728536675704293 0.920151801368984 GO:0043015 gamma-tubulin binding 1/681 35/18639 0.0285714285714286 0.782001258653241 0.728536675704293 0.920151801368984 GO:0061631 ubiquitin conjugating enzyme activity 1/681 35/18639 0.0285714285714286 0.782001258653241 0.728536675704293 0.920151801368984 GO:0140566 histone reader activity 1/681 35/18639 0.0285714285714286 0.782001258653241 0.728536675704293 0.920151801368984 GO:0017171 serine hydrolase activity 6/681 198/18639 0.0303030303030303 0.829395274329195 0.734563291265624 0.926494329065534 GO:0004190 aspartic-type endopeptidase activity 1/681 36/18639 0.0277777777777778 0.760279001468429 0.738473599153303 0.927619425639435 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 1/681 36/18639 0.0277777777777778 0.760279001468429 0.738473599153303 0.927619425639435 GO:0016409 palmitoyltransferase activity 1/681 36/18639 0.0277777777777778 0.760279001468429 0.738473599153303 0.927619425639435 GO:0005085 guanyl-nucleotide exchange factor activity 7/681 230/18639 0.0304347826086957 0.833001340739322 0.739906189459895 0.928154430859896 GO:0030280 structural constituent of skin epidermis 1/681 37/18639 0.027027027027027 0.73973092034766 0.748047295813874 0.934371742819624 GO:0030551 cyclic nucleotide binding 1/681 37/18639 0.027027027027027 0.73973092034766 0.748047295813874 0.934371742819624 GO:0070001 aspartic-type peptidase activity 1/681 37/18639 0.027027027027027 0.73973092034766 0.748047295813874 0.934371742819624 GO:0000149 SNARE binding 3/681 106/18639 0.0283018867924528 0.774623888288588 0.748916179982323 0.934371742819624 GO:0015631 tubulin binding 12/681 385/18639 0.0311688311688312 0.853092282167172 0.752934125087621 0.938115220717279 GO:0005109 frizzled binding 1/681 38/18639 0.0263157894736842 0.720264317180617 0.757271023990992 0.938446080806041 GO:0005501 retinoid binding 1/681 38/18639 0.0263157894736842 0.720264317180617 0.757271023990992 0.938446080806041 GO:0019840 isoprenoid binding 1/681 38/18639 0.0263157894736842 0.720264317180617 0.757271023990992 0.938446080806041 GO:0042162 telomeric DNA binding 1/681 38/18639 0.0263157894736842 0.720264317180617 0.757271023990992 0.938446080806041 GO:0031491 nucleosome binding 2/681 74/18639 0.027027027027027 0.73973092034766 0.758330537530074 0.938497658527152 GO:0005496 steroid binding 3/681 108/18639 0.0277777777777778 0.760279001468429 0.760143151490424 0.93947987355787 GO:0000217 DNA secondary structure binding 1/681 39/18639 0.0256410256410256 0.701796001355473 0.766157558729024 0.943120519556956 GO:0016776 phosphotransferase activity, phosphate group as acceptor 1/681 39/18639 0.0256410256410256 0.701796001355473 0.766157558729024 0.943120519556956 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 1/681 39/18639 0.0256410256410256 0.701796001355473 0.766157558729024 0.943120519556956 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 8/681 268/18639 0.0298507462686567 0.817016240383983 0.767327641691605 0.943301447519546 GO:0008514 organic anion transmembrane transporter activity 8/681 269/18639 0.0297397769516729 0.813979005289619 0.770831084711129 0.9455932429698 GO:0051536 iron-sulfur cluster binding 2/681 76/18639 0.0263157894736842 0.720264317180617 0.771243078864739 0.9455932429698 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 1/681 40/18639 0.025 0.684251101321586 0.774719209401365 0.947335691071695 GO:0050997 quaternary ammonium group binding 1/681 40/18639 0.025 0.684251101321586 0.774719209401365 0.947335691071695 GO:0005096 GTPase activator activity 8/681 271/18639 0.029520295202952 0.80797178015833 0.777723508631171 0.949749768156212 GO:0016877 ligase activity, forming carbon-sulfur bonds 1/681 41/18639 0.024390243902439 0.66756205006984 0.78296783666077 0.953627933158824 GO:0140828 metal cation:monoatomic cation antiporter activity 1/681 41/18639 0.024390243902439 0.66756205006984 0.78296783666077 0.953627933158824 GO:0015293 symporter activity 4/681 146/18639 0.0273972602739726 0.749864220626395 0.785201226763788 0.95508645260714 GO:0015370 solute:sodium symporter activity 2/681 79/18639 0.0253164556962025 0.692912507667429 0.789482782597229 0.956244058079777 GO:0015085 calcium ion transmembrane transporter activity 4/681 147/18639 0.0272108843537415 0.744763103479277 0.789626657858225 0.956244058079777 GO:0031492 nucleosomal DNA binding 1/681 42/18639 0.0238095238095238 0.651667715544368 0.790914868773578 0.956244058079777 GO:0051879 Hsp90 protein binding 1/681 42/18639 0.0238095238095238 0.651667715544368 0.790914868773578 0.956244058079777 GO:0030695 GTPase regulator activity 15/681 489/18639 0.0306748466257669 0.839571903462069 0.791338629408752 0.956244058079777 GO:0060589 nucleoside-triphosphatase regulator activity 15/681 490/18639 0.0306122448979592 0.837858491414187 0.793810445910617 0.957975433415692 GO:0046982 protein heterodimerization activity 11/681 369/18639 0.029810298102981 0.815909172307582 0.794978184108288 0.958130569605022 GO:0005245 voltage-gated calcium channel activity 1/681 43/18639 0.0232558139534884 0.636512652392173 0.798571317360189 0.959951440164399 GO:0008375 acetylglucosaminyltransferase activity 1/681 43/18639 0.0232558139534884 0.636512652392173 0.798571317360189 0.959951440164399 GO:0043014 alpha-tubulin binding 1/681 44/18639 0.0227272727272727 0.622046455746896 0.805947792563335 0.967557115551295 GO:0008135 translation factor activity, RNA binding 2/681 83/18639 0.0240963855421687 0.659519133803938 0.811801736684305 0.971031431719011 GO:0004715 non-membrane spanning protein tyrosine kinase activity 1/681 45/18639 0.0222222222222222 0.608223201174743 0.813054517664942 0.971031431719011 GO:0051539 4 iron, 4 sulfur cluster binding 1/681 45/18639 0.0222222222222222 0.608223201174743 0.813054517664942 0.971031431719011 GO:0140303 intramembrane lipid transporter activity 1/681 45/18639 0.0222222222222222 0.608223201174743 0.813054517664942 0.971031431719011 GO:0180051 translation factor activity 2/681 84/18639 0.0238095238095238 0.651667715544368 0.81704133828802 0.973651808445595 GO:0051020 GTPase binding 9/681 315/18639 0.0285714285714286 0.782001258653241 0.817360628781877 0.973651808445595 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 1/681 46/18639 0.0217391304347826 0.595000957670944 0.819901343171566 0.974161131964154 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 1/681 46/18639 0.0217391304347826 0.595000957670944 0.819901343171566 0.974161131964154 GO:0046943 carboxylic acid transmembrane transporter activity 5/681 188/18639 0.0265957446808511 0.727926703533602 0.821215364529402 0.974466623032315 GO:0005342 organic acid transmembrane transporter activity 5/681 189/18639 0.0264550264550265 0.724075239493742 0.824700437022119 0.977344219710018 GO:0015291 secondary active transmembrane transporter activity 8/681 287/18639 0.0278745644599303 0.762928057222674 0.827466042592682 0.978416981123622 GO:0008528 G protein-coupled peptide receptor activity 3/681 122/18639 0.0245901639344262 0.67303387015238 0.827728031753172 0.978416981123622 GO:0008188 neuropeptide receptor activity 1/681 48/18639 0.0208333333333333 0.570209251101322 0.832852914495732 0.981957016835122 GO:0016879 ligase activity, forming carbon-nitrogen bonds 1/681 48/18639 0.0208333333333333 0.570209251101322 0.832852914495732 0.981957016835122 GO:0003727 single-stranded RNA binding 2/681 89/18639 0.0224719101123595 0.615057169727268 0.841326460579044 0.990680710924494 GO:0042826 histone deacetylase binding 3/681 127/18639 0.0236220472440945 0.646536473689687 0.847572969965527 0.994795937574439 GO:0005048 signal sequence binding 1/681 51/18639 0.0196078431372549 0.536667530448303 0.850557319656847 0.994795937574439 GO:0005272 sodium channel activity 1/681 51/18639 0.0196078431372549 0.536667530448303 0.850557319656847 0.994795937574439 GO:0016830 carbon-carbon lyase activity 1/681 51/18639 0.0196078431372549 0.536667530448303 0.850557319656847 0.994795937574439 GO:0030544 Hsp70 protein binding 1/681 51/18639 0.0196078431372549 0.536667530448303 0.850557319656847 0.994795937574439 GO:0001653 peptide receptor activity 3/681 128/18639 0.0234375 0.641485407488987 0.851295005147757 0.994795937574439 GO:0015081 sodium ion transmembrane transporter activity 4/681 164/18639 0.024390243902439 0.66756205006984 0.854196861927782 0.99596735196937 GO:0043178 alcohol binding 2/681 92/18639 0.0217391304347826 0.595000957670944 0.8544578908978 0.99596735196937 GO:0030159 signaling receptor complex adaptor activity 1/681 52/18639 0.0192307692307692 0.526347001016605 0.856032382348567 0.996542748138105 GO:0004864 protein phosphatase inhibitor activity 1/681 53/18639 0.0188679245283019 0.516415925525725 0.861307141460884 0.997644704053938 GO:0008146 sulfotransferase activity 1/681 53/18639 0.0188679245283019 0.516415925525725 0.861307141460884 0.997644704053938 GO:0051018 protein kinase A binding 1/681 53/18639 0.0188679245283019 0.516415925525725 0.861307141460884 0.997644704053938 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 1/681 53/18639 0.0188679245283019 0.516415925525725 0.861307141460884 0.997644704053938 GO:0016410 N-acyltransferase activity 2/681 94/18639 0.0212765957446809 0.582341362826882 0.862653416389584 0.997852588692373 GO:0016874 ligase activity 4/681 167/18639 0.0239520958083832 0.655569917433855 0.863651155939819 0.997852588692373 GO:0015485 cholesterol binding 1/681 54/18639 0.0185185185185185 0.506852667645619 0.866388914659266 0.998513224144804 GO:0050661 NADP binding 1/681 54/18639 0.0185185185185185 0.506852667645619 0.866388914659266 0.998513224144804 GO:0016407 acetyltransferase activity 2/681 96/18639 0.0208333333333333 0.570209251101322 0.870424271358825 0.9999808750663 GO:0030594 neurotransmitter receptor activity 2/681 97/18639 0.0206185567010309 0.564330805213679 0.874156292238941 0.9999808750663 GO:0019212 phosphatase inhibitor activity 1/681 56/18639 0.0178571428571429 0.488750786658276 0.876001448921117 0.9999808750663 GO:0005249 voltage-gated potassium channel activity 2/681 98/18639 0.0204081632653061 0.558572327609458 0.877789099756562 0.9999808750663 GO:0005261 monoatomic cation channel activity 9/681 341/18639 0.0263929618768328 0.72237652925446 0.879668407353671 0.9999808750663 GO:0005244 voltage-gated monoatomic ion channel activity 4/681 173/18639 0.023121387283237 0.632833388505513 0.880992824990897 0.9999808750663 GO:0008017 microtubule binding 7/681 276/18639 0.0253623188405797 0.694167783949435 0.88148746112497 0.9999808750663 GO:0022832 voltage-gated channel activity 4/681 175/18639 0.0228571428571429 0.625601006922593 0.886332303652205 0.9999808750663 GO:0004252 serine-type endopeptidase activity 4/681 176/18639 0.0227272727272727 0.622046455746896 0.888922896833089 0.9999808750663 GO:0036002 pre-mRNA binding 1/681 59/18639 0.0169491525423729 0.463899051743448 0.8891409581101 0.9999808750663 GO:0042393 histone binding 6/681 247/18639 0.0242914979757085 0.664859369705185 0.891823633858419 0.9999808750663 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 1/681 60/18639 0.0166666666666667 0.456167400881057 0.893204198558271 0.9999808750663 GO:0016836 hydro-lyase activity 1/681 61/18639 0.0163934426229508 0.448689246768253 0.897118722525213 0.9999808750663 GO:0019905 syntaxin binding 1/681 61/18639 0.0163934426229508 0.448689246768253 0.897118722525213 0.9999808750663 GO:0022843 voltage-gated monoatomic cation channel activity 3/681 143/18639 0.020979020979021 0.57419672838175 0.89828982523911 0.9999808750663 GO:0015179 L-amino acid transmembrane transporter activity 1/681 62/18639 0.0161290322580645 0.441452323433281 0.900889965390986 0.9999808750663 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 4/681 181/18639 0.0220994475138122 0.604862851996982 0.901115756162865 0.9999808750663 GO:0008194 UDP-glycosyltransferase activity 3/681 145/18639 0.0206896551724138 0.566276773507519 0.903428164410861 0.9999808750663 GO:0004497 monooxygenase activity 2/681 106/18639 0.0188679245283019 0.516415925525725 0.903543536963421 0.9999808750663 GO:0022824 transmitter-gated monoatomic ion channel activity 1/681 63/18639 0.0158730158730159 0.434445143696245 0.904523164161979 0.9999808750663 GO:0022835 transmitter-gated channel activity 1/681 63/18639 0.0158730158730159 0.434445143696245 0.904523164161979 0.9999808750663 GO:0004843 cysteine-type deubiquitinase activity 2/681 108/18639 0.0185185185185185 0.506852667645619 0.909140115630612 0.9999808750663 GO:0019843 rRNA binding 1/681 65/18639 0.0153846153846154 0.421077600813284 0.91139542869194 0.9999808750663 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 1/681 67/18639 0.0149253731343284 0.408508120191992 0.917773712919918 0.9999808750663 GO:0003777 microtubule motor activity 1/681 68/18639 0.0147058823529412 0.402500647836227 0.920788794844403 0.9999808750663 GO:0005548 phospholipid transporter activity 1/681 68/18639 0.0147058823529412 0.402500647836227 0.920788794844403 0.9999808750663 GO:0030145 manganese ion binding 1/681 68/18639 0.0147058823529412 0.402500647836227 0.920788794844403 0.9999808750663 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 5/681 229/18639 0.0218340611353712 0.597599215128023 0.924578442213958 0.9999808750663 GO:0000287 magnesium ion binding 5/681 230/18639 0.0217391304347826 0.595000957670944 0.926245835782785 0.9999808750663 GO:0101005 deubiquitinase activity 2/681 115/18639 0.0173913043478261 0.476000766136755 0.926422033799777 0.9999808750663 GO:0016782 transferase activity, transferring sulphur-containing groups 1/681 70/18639 0.0142857142857143 0.39100062932662 0.926491792635737 0.9999808750663 GO:0140299 molecular sensor activity 1/681 71/18639 0.0140845070422535 0.385493578209344 0.929187634588188 0.9999808750663 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 1/681 73/18639 0.0136986301369863 0.374932110313198 0.934286746434238 0.9999808750663 GO:0015079 potassium ion transmembrane transporter activity 3/681 160/18639 0.01875 0.513188325991189 0.935059166312153 0.9999808750663 GO:0015108 chloride transmembrane transporter activity 2/681 121/18639 0.0165289256198347 0.452397422361379 0.938719003973809 0.9999808750663 GO:0003725 double-stranded RNA binding 1/681 75/18639 0.0133333333333333 0.364933920704846 0.939019177702796 0.9999808750663 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 2/681 122/18639 0.0163934426229508 0.448689246768253 0.940568853510819 0.9999808750663 GO:0046873 metal ion transmembrane transporter activity 11/681 450/18639 0.0244444444444444 0.669045521292217 0.942033208101131 0.9999808750663 GO:0005267 potassium channel activity 2/681 124/18639 0.0161290322580645 0.441452323433281 0.944110642068642 0.9999808750663 GO:0019199 transmembrane receptor protein kinase activity 1/681 78/18639 0.0128205128205128 0.350898000677736 0.94548738023392 0.9999808750663 GO:0016835 carbon-oxygen lyase activity 1/681 79/18639 0.0126582278481013 0.346456253833714 0.94748743917798 0.9999808750663 GO:0019783 ubiquitin-like protein peptidase activity 2/681 127/18639 0.015748031496063 0.431024315793125 0.949049133873412 0.9999808750663 GO:0000049 tRNA binding 1/681 80/18639 0.0125 0.342125550660793 0.949414220100383 0.9999808750663 GO:0031490 chromatin DNA binding 2/681 128/18639 0.015625 0.427656938325991 0.950600786710327 0.9999808750663 GO:0035591 signaling adaptor activity 2/681 129/18639 0.0155038759689922 0.424341768261449 0.952107293117732 0.9999808750663 GO:0016755 aminoacyltransferase activity 12/681 496/18639 0.0241935483870968 0.662178485149922 0.953220159916604 0.9999808750663 GO:0005254 chloride channel activity 1/681 83/18639 0.0120481927710843 0.329759566901969 0.954781218093908 0.9999808750663 GO:0015297 antiporter activity 2/681 135/18639 0.0148148148148148 0.405482134116495 0.960264658304926 0.9999808750663 GO:0099094 ligand-gated monoatomic cation channel activity 2/681 136/18639 0.0147058823529412 0.402500647836227 0.961487755538163 0.9999808750663 GO:0140767 enzyme-substrate adaptor activity 2/681 139/18639 0.0143884892086331 0.393813583494438 0.964944101824671 0.9999808750663 GO:0019787 ubiquitin-like protein transferase activity 11/681 479/18639 0.022964509394572 0.628539633781833 0.965536261764133 0.9999808750663 GO:0052689 carboxylic ester hydrolase activity 1/681 92/18639 0.0108695652173913 0.297500478835472 0.967704506224258 0.9999808750663 GO:0005216 monoatomic ion channel activity 10/681 448/18639 0.0223214285714286 0.610938483322845 0.967901602106229 0.9999808750663 GO:0016757 glycosyltransferase activity 5/681 267/18639 0.0187265917602996 0.51254764143939 0.96891151104955 0.9999808750663 GO:0008509 monoatomic anion transmembrane transporter activity 2/681 149/18639 0.0134228187919463 0.367383141649174 0.974439283158745 0.9999808750663 GO:0016758 hexosyltransferase activity 3/681 197/18639 0.0152284263959391 0.416802701312641 0.976810975927273 0.9999808750663 GO:0022836 gated channel activity 6/681 318/18639 0.0188679245283019 0.516415925525725 0.976972753241338 0.9999808750663 GO:0015171 amino acid transmembrane transporter activity 1/681 102/18639 0.00980392156862745 0.268333765224151 0.977785408713345 0.9999808750663 GO:0005253 monoatomic anion channel activity 1/681 103/18639 0.00970873786407767 0.265728583037509 0.978601513620623 0.9999808750663 GO:0004386 helicase activity 2/681 155/18639 0.0129032258064516 0.353161858746625 0.978888043849655 0.9999808750663 GO:0140658 ATP-dependent chromatin remodeler activity 2/681 158/18639 0.0126582278481013 0.346456253833714 0.980821532843869 0.9999808750663 GO:0140104 molecular carrier activity 4/681 249/18639 0.0160642570281124 0.439679422535959 0.982275144635423 0.9999808750663 GO:0015103 inorganic anion transmembrane transporter activity 2/681 165/18639 0.0121212121212121 0.331758109731678 0.984688853939629 0.9999808750663 GO:0043022 ribosome binding 1/681 112/18639 0.00892857142857143 0.244375393329138 0.984722743237086 0.9999808750663 GO:0004842 ubiquitin-protein transferase activity 9/681 449/18639 0.0200445434298441 0.548620036694367 0.984804714108194 0.9999808750663 GO:0140097 catalytic activity, acting on DNA 6/681 336/18639 0.0178571428571429 0.488750786658276 0.984992681451286 0.9999808750663 GO:0035401 histone H3Y41 kinase activity 1/681 115/18639 0.00869565217391304 0.238000383068378 0.986346309457495 0.9999808750663 GO:0140801 histone H2AXY142 kinase activity 1/681 115/18639 0.00869565217391304 0.238000383068378 0.986346309457495 0.9999808750663 GO:0003730 mRNA 3'-UTR binding 4/681 262/18639 0.0152671755725191 0.417863267982648 0.987539033083011 0.9999808750663 GO:0043021 ribonucleoprotein complex binding 2/681 177/18639 0.0112994350282486 0.309266034495632 0.989626918693682 0.9999808750663 GO:0061630 ubiquitin protein ligase activity 6/681 353/18639 0.0169971671388102 0.465213213363118 0.990094951799826 0.9999808750663 GO:0015276 ligand-gated monoatomic ion channel activity 2/681 186/18639 0.010752688172043 0.294301548955521 0.992273287493056 0.9999808750663 GO:0022834 ligand-gated channel activity 2/681 188/18639 0.0106382978723404 0.291170681413441 0.992764784958961 0.9999808750663 GO:0140597 protein carrier chaperone 2/681 188/18639 0.0106382978723404 0.291170681413441 0.992764784958961 0.9999808750663 GO:0016779 nucleotidyltransferase activity 1/681 136/18639 0.00735294117647059 0.201250323918114 0.993784770479239 0.9999808750663 GO:0061659 ubiquitin-like protein ligase activity 6/681 372/18639 0.0161290322580645 0.441452323433281 0.993847324668607 0.9999808750663 GO:0140101 catalytic activity, acting on a tRNA 1/681 139/18639 0.00719424460431655 0.196906791747219 0.994446109002708 0.9999808750663 GO:0004713 protein tyrosine kinase activity 1/681 140/18639 0.00714285714285714 0.19550031466331 0.994650552233474 0.9999808750663 GO:0000510 H3-H4 histone complex chaperone activity 1/681 151/18639 0.00662251655629139 0.181258569886513 0.996459396400147 0.9999808750663 GO:0140584 chromatin extrusion motor activity 1/681 151/18639 0.00662251655629139 0.181258569886513 0.996459396400147 0.9999808750663 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 1/681 151/18639 0.00662251655629139 0.181258569886513 0.996459396400147 0.9999808750663 GO:0140849 ATP-dependent H2AZ histone chaperone activity 1/681 151/18639 0.00662251655629139 0.181258569886513 0.996459396400147 0.9999808750663 GO:0008094 ATP-dependent activity, acting on DNA 2/681 210/18639 0.00952380952380952 0.260667086217747 0.996509504735779 0.9999808750663 GO:0015616 DNA translocase activity 1/681 152/18639 0.00657894736842105 0.180066079295154 0.996589813484283 0.9999808750663 GO:0140674 ATP-dependent histone chaperone activity 1/681 152/18639 0.00657894736842105 0.180066079295154 0.996589813484283 0.9999808750663 GO:0061775 cohesin loader activity 1/681 153/18639 0.0065359477124183 0.178889176816101 0.996715433488459 0.9999808750663 GO:0003689 DNA clamp loader activity 1/681 160/18639 0.00625 0.171062775330396 0.997474470815143 0.9999808750663 GO:0140713 histone chaperone activity 1/681 164/18639 0.00609756097560976 0.16689051251746 0.997826708691175 0.9999808750663 GO:0016887 ATP hydrolysis activity 6/681 417/18639 0.0143884892086331 0.393813583494438 0.998094015340792 0.9999808750663 GO:0140098 catalytic activity, acting on RNA 5/681 387/18639 0.0129198966408269 0.353618140217874 0.998696438314242 0.9999808750663 GO:0004674 protein serine/threonine kinase activity 6/681 433/18639 0.0138568129330254 0.379261580409193 0.998760229385695 0.9999808750663 GO:0004679 AMP-activated protein kinase activity 2/681 248/18639 0.00806451612903226 0.220726161716641 0.999030548649924 0.9999808750663 GO:0045182 translation regulator activity 4/681 356/18639 0.0112359550561798 0.307528584863634 0.999167519021982 0.9999808750663 GO:0008168 methyltransferase activity 1/681 204/18639 0.00490196078431373 0.134166882612076 0.999516962595449 0.9999808750663 GO:0016741 transferase activity, transferring one-carbon groups 1/681 215/18639 0.00465116279069767 0.127302530478435 0.999680761800513 0.9999808750663 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 1/681 243/18639 0.00411522633744856 0.112633926143471 0.999888883107106 0.9999808750663 GO:0004676 3-phosphoinositide-dependent protein kinase activity 1/681 245/18639 0.00408163265306122 0.111714465521892 0.999896957901935 0.9999808750663 GO:0004711 ribosomal protein S6 kinase activity 1/681 245/18639 0.00408163265306122 0.111714465521892 0.999896957901935 0.9999808750663 GO:0035175 histone H3S10 kinase activity 1/681 245/18639 0.00408163265306122 0.111714465521892 0.999896957901935 0.9999808750663 GO:0035979 histone H2AXS139 kinase activity 1/681 245/18639 0.00408163265306122 0.111714465521892 0.999896957901935 0.9999808750663 GO:0044022 histone H3S28 kinase activity 1/681 245/18639 0.00408163265306122 0.111714465521892 0.999896957901935 0.9999808750663 GO:0044023 histone H4S1 kinase activity 1/681 245/18639 0.00408163265306122 0.111714465521892 0.999896957901935 0.9999808750663 GO:0044024 histone H2AS1 kinase activity 1/681 245/18639 0.00408163265306122 0.111714465521892 0.999896957901935 0.9999808750663 GO:0044025 histone H2BS14 kinase activity 1/681 245/18639 0.00408163265306122 0.111714465521892 0.999896957901935 0.9999808750663 GO:0072354 histone H3T3 kinase activity 1/681 245/18639 0.00408163265306122 0.111714465521892 0.999896957901935 0.9999808750663 GO:0072371 histone H2AS121 kinase activity 1/681 245/18639 0.00408163265306122 0.111714465521892 0.999896957901935 0.9999808750663 GO:0072518 Rho-dependent protein serine/threonine kinase activity 1/681 245/18639 0.00408163265306122 0.111714465521892 0.999896957901935 0.9999808750663 GO:0140823 histone H2BS36 kinase activity 1/681 245/18639 0.00408163265306122 0.111714465521892 0.999896957901935 0.9999808750663 GO:0140855 histone H3S57 kinase activity 1/681 245/18639 0.00408163265306122 0.111714465521892 0.999896957901935 0.9999808750663 GO:0140995 histone H2A kinase activity 1/681 245/18639 0.00408163265306122 0.111714465521892 0.999896957901935 0.9999808750663 GO:0140997 histone H4 kinase activity 1/681 245/18639 0.00408163265306122 0.111714465521892 0.999896957901935 0.9999808750663 GO:0140998 histone H2B kinase activity 1/681 245/18639 0.00408163265306122 0.111714465521892 0.999896957901935 0.9999808750663 GO:1990244 histone H2AT120 kinase activity 1/681 245/18639 0.00408163265306122 0.111714465521892 0.999896957901935 0.9999808750663 GO:0004677 DNA-dependent protein kinase activity 1/681 246/18639 0.0040650406504065 0.111260341678307 0.999900772823582 0.9999808750663 GO:0140857 histone H3T45 kinase activity 1/681 246/18639 0.0040650406504065 0.111260341678307 0.999900772823582 0.9999808750663 GO:0035402 histone H3T11 kinase activity 1/681 247/18639 0.00404858299595142 0.110809894950864 0.999904446705338 0.9999808750663 GO:0035403 histone H3T6 kinase activity 1/681 247/18639 0.00404858299595142 0.110809894950864 0.999904446705338 0.9999808750663 GO:0030371 translation repressor activity 2/681 329/18639 0.0060790273556231 0.166383246521966 0.999941038827944 0.9999808750663 GO:0141003 histone H2AX kinase activity 2/681 354/18639 0.00564971751412429 0.154633017247816 0.999975514281091 0.9999808750663 GO:0140996 histone H3 kinase activity 2/681 357/18639 0.00560224089635854 0.153333580128086 0.999977973534683 0.9999808750663 GO:0035173 histone kinase activity 2/681 360/18639 0.00555555555555556 0.152055800293686 0.999980187379952 0.9999808750663 GO:0106310 protein serine kinase activity 2/681 361/18639 0.00554016620498615 0.151634593090656 0.9999808750663 0.9999808750663