category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	98/1774	250/9376	2.07181059751973	LAPTM4A/CTSS/LAPTM5/PSAP/GAA/SLC29A1/CTSB/CTSD/CLTB/BLOC1S6/CTSO/SLC15A3/HGSNAT/IGF2R/CTSA/NAGLU/ATP6V1G1/LAMP2/ASAH1/CTSL/VAMP7/HEXA/SLC17A5/ARSG/ATP6V0D1/GALNS/LGMN/ATP6V0E1/CD68/TPP1/OSBPL1A/GUSB/ENTPD4/IDS/RRAGC/AGA/ATP6V1H/VPS35/SUMF1/CLN5/CTBS/AP2A2/MCOLN1/AP5S1/ATP6V1A/GNS/VPS13C/NAGA/ATP6V1D/CLCN7/AP1G1/GLB1/GGA1/LITAF/ATP6V0A1/GM2A/SGSH/ACP2/ATP6AP1/SLC29A3/GNPTG/PLA2G15/AP2B1/SLC38A9/PIKFYVE/SPG11/AP4E1/SLC15A4/SNAP29/SLC11A1/STX17/CD164/ATP6V1E1/GNPTAB/MTOR/ATP6V1B2/AP1S2/TMEM175/ARSA/TPCN1/GGA3/VPS11/SMPD1/OSBP/AP5Z1/LIPA/MFSD8/NEU1/NAGPA/TLR3/PPT2/DMXL2/ROGDI/CTSF/VPS41/NPC1/TELO2/FIG4	8.2974822539514
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	57/1774	119/9376	2.53158129091546	NFKBIA/FOS/CXCL2/CXCL3/PIK3R1/MAPK3/IL1B/CREB5/JUN/MAP2K3/IRF1/CEBPB/MMP9/CCL20/TNFAIP3/ADAM17/ICAM1/XIAP/NFKB1/CREB3L2/ATF4/TNF/MAP3K5/CYLD/CCL2/CCL5/PIK3CA/ATF6B/JUNB/CXCL10/MAP2K1/MAP3K7/MAP2K7/FADD/CASP3/BIRC3/CFLAR/RIPK1/MAP2K4/RHBDF1/BIRC2/MLKL/PTGS2/CREB1/RPS6KA5/ATF2/FRMD8/PIK3R2/MAPK1/TAB2/BCL3/CASP7/PIK3R3/CREB3L4/RPS6KA4/MAPK8/ITCH	8.12226050919236
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	86/1774	224/9376	2.02915123208246	HLA-B/HLA-DRA/HLA-DPA1/NFKBIA/FOS/HLA-DPB1/ETS2/HLA-DRB1/CDKN1A/CDKN2A/HLA-A/CCNE1/PIK3R1/HLA-DQB1/MAPK3/HLA-DQA1/TGFB2/CREB5/JUN/ITGB2/TGFBR1/TLN2/ZFP36/HLA-DMB/ANAPC13/IL2RB/PPP3CA/HLA-DMA/EGR1/ANAPC16/ICAM1/EP300/CD40/XIAP/NFKB1/SPI1/CREB3L2/VAC14/ATF4/CREBBP/HLA-DRB5/TNF/HLA-DQA2/SMAD4/MMP7/NRP1/PPP3R1/CDKN2B/PIK3CA/ATF6B/MAP2K1/CDC23/CD4/TBP/HLA-F/MAP3K1/HLA-E/SMAD2/RB1/SRF/DLG1/MAP2K4/EGR2/MAP3K3/CRTC3/ATM/ELK4/CREB1/KAT5/ITGAL/NFATC3/POLB/ATF2/PIK3R2/GPS2/MAPK1/NFKB2/KRAS/PPP3CB/IL2RG/PIK3R3/CREB3L4/ATR/ADCY7/MAPK8/RANBP3	7.53084510462263
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	111/1774	333/9376	1.76174370537392	SPP1/HLA-B/COL4A1/FN1/COL4A2/TCF7L2/CDKN1A/HLA-A/FOXO1/CCNE1/PIK3R1/MAPK3/PARD6G/LAMC1/ITGA6/CREB5/PPP2CB/NOTCH2/ITGB1/TCF7/MDM2/IRF1/ITGA5/MAML2/ATP6V1G1/WNT7A/SOS1/ATP6V0D1/EP300/ATP6V0E1/ITGB6/STAT2/NFKB1/CREB3L2/CHD4/CREBBP/IFNAR1/TNF/AXIN2/RBL2/LAMC2/ATP6V1H/PTK2/TSC1/ATP6V1A/PTGER4/PIK3CA/FZD6/ATP6V1D/FZD1/RAF1/MAP2K1/LAMA5/ATP6V0A1/PSEN1/TBP/UBE3A/FADD/ATP6AP1/CASP3/ITGA1/WNT6/PPP2R3C/PPP2R5E/HLA-F/STAT1/FZD7/HLA-E/EIF2AK2/TBK1/RB1/TCF7L1/DLG1/IKBKE/ATM/FZD8/PTGS2/RHEB/LFNG/ATP6V1E1/MAML1/TSC2/CREB1/UBR4/HDAC2/PPP2CA/WNT2B/MTOR/ATP6V1B2/MX2/RBPJ/PIK3R2/PPP2R2D/MAPK1/KRAS/ITGAV/GSK3B/TLR3/RPS6KB1/PIK3R3/COL9A3/DVL2/ITGA3/CREB3L4/WNT5B/ATR/HES2/VEGFA/MX1/CDKN1B/ITGA2	6.83712057321345
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	49/1774	109/9376	2.37592958431162	HLA-DRA/EBI3/HLA-DPA1/NFKBIA/FOS/HLA-DPB1/HLA-DRB1/IL1RAP/GATA3/HLA-DQB1/MAPK3/HLA-DQA1/IL1B/IL6ST/JUN/TGFBR1/HLA-DMB/HSP90AB1/IL2RB/PPP3CA/HLA-DMA/RXRA/STAT6/HSP90AA1/NFKB1/RXRB/AHR/HLA-DRB5/IFNGR1/HLA-DQA2/SMAD4/PPP3R1/RUNX1/HIF1A/CD4/STAT1/SMAD2/IL27/NFKBIE/RARA/STAT3/NFATC3/MTOR/MAPK1/IL12RB1/PPP3CB/IL2RG/JAK2/MAPK8	6.97972624722755
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	65/1774	169/9376	2.03278119850837	CTSB/MAP1LC3B/PIK3R1/CTSD/MAPK3/PPP2CB/IRS2/GABARAPL2/UBB/GABARAP/LAMP2/CTSL/DAPK1/STX7/SH3GLB1/GABARAPL1/PDPK1/SQSTM1/RAB1A/DDIT4/RRAGC/TSC1/PIK3CA/SUPT20H/BIRC6/HIF1A/RAF1/MAP2K1/EIF2AK3/MAP3K7/UBC/CFLAR/TBK1/DAPK3/SNAP29/TP53INP2/WDR45B/STX17/OPTN/RHEB/TSC2/RRAS2/WIPI1/PRKAA1/PPP2CA/MTOR/PIK3R2/GORASP1/ULK2/NBR1/MAPK1/TRAF6/ATG14/KRAS/ATG16L2/VPS11/WDFY3/RPS6KB1/RB1CC1/ATG2B/ATG13/PIK3R3/VPS41/MAPK8/CAMKK2	6.54472069502238
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	38/1774	78/9376	2.57485618477727	HLA-DRA/HLA-DPA1/NFKBIA/FOS/EEF1A1/HLA-DPB1/HLA-DRB1/HLA-DQB1/MAPK3/HLA-DQA1/TGFB2/IL1B/JUN/ITGB2/ITGB1/FCGR3A/HLA-DMB/HLA-DMA/NCF2/NFKB1/NOS2/HLA-DRB5/TNF/IFNGR1/HLA-DQA2/CYBB/MAP3K7/FCGR2A/FCGR1A/ITGAM/STAT1/MARCKSL1/PTGS2/MAPK1/TRAF6/TAB2/JAK2/PTPN6	6.74670846512037
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	61/1774	157/9376	2.05349744002183	HLA-B/SERPINE1/IGFBP3/CDKN1A/CDKN2A/HLA-A/FOXO1/CCNE1/ZFP36L1/PIK3R1/MAPK3/TGFB2/FOXO3/GADD45A/MAP2K3/TGFBR1/ITPR2/MDM2/HIPK2/PPP3CA/HIPK3/NFKB1/SQSTM1/RBBP4/RBL2/TSC1/ITPR3/CAPN2/PPP3R1/CDKN2B/PIK3CA/RAF1/MAP2K1/SIRT1/GADD45B/TRPM7/HLA-F/HIPK1/HLA-E/SMAD2/RB1/ZFP36L2/RAD9A/FBXW11/PPP1CC/ATM/RHEB/TSC2/RRAS2/NFATC3/TRAF3IP2/LIN52/MTOR/PIK3R2/MAPK1/KRAS/PPP3CB/PIK3R3/MCU/ATR/RAD1	6.43042854413407
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	48/1774	112/9376	2.26509904976647	HLA-DRA/HLA-DPA1/NFKBIA/HLA-DPB1/HLA-DRB1/HSPA1B/HLA-DQB1/MAPK3/HLA-DQA1/PPIF/TGFB2/LAMC1/ITGA6/ITGB1/MAP2K3/IL10RB/HLA-DMB/HLA-DMA/HSPA8/LY96/LDLR/CD40/XIAP/NFKB1/NOS2/PDPK1/HLA-DRB5/TNF/IL10RA/IFNGR1/HLA-DQA2/HSPA6/LAMC2/SOCS1/LAMA5/MAP3K7/CASP3/STAT1/BIRC3/BIRC2/STAT3/ALOX5/MAPK1/TRAF6/TAB2/JAK2/MAPK8/BIRC7	6.50628047381295
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	56/1774	142/9376	2.08431649649872	HERC1/UBE2A/UBB/MDM2/ANAPC13/ANAPC16/XIAP/UBE2K/SKP1/UBE2Q1/DDB1/MID1/SOCS1/UBE2G2/UBE2E2/UBA7/UBR5/VHL/BIRC6/CUL5/CDC23/UBC/WWP2/HUWE1/KLHL9/UBE3A/UBE2Z/UBE2W/BIRC3/UBE2D1/MAP3K1/PPIL2/SIAH1/BIRC2/HERC2/FBXW11/TRIP12/NEDD4/UBE2D4/RHOBTB1/CUL3/UBE3C/NEDD4L/UBE2H/TRAF6/UBE2O/UBE4A/UBE2J1/WWP1/FBXW8/PIAS1/FBXO2/ITCH/BIRC7/UBE4B/UBE2L6	6.28932178571751
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	76/1774	216/9376	1.85961835567247	NFKBIA/FOS/VLDLR/CCL3/CXCL2/HSPA1B/ABCA1/CXCL3/PIK3R1/MAPK3/VAV3/IL1B/JUN/MAP2K3/ABCG1/OLR1/MMP9/HSP90AB1/PPP3CA/CAMK2G/RXRA/HSPA8/LY96/LDLR/CD36/ICAM1/CD40/NCF2/HSP90AA1/NFKB1/ATF4/PDPK1/RXRB/TNF/MAP3K5/TNFSF10/HSPA6/PTK2/CD14/CCL2/CCL5/CYBB/PPP3R1/PIK3CA/EIF2AK3/MAP3K7/MIB1/MAP2K7/CASP3/TBK1/MAP2K4/IKBKE/NFE2L2/VAV2/ROCK2/DDIT3/STAT3/POU2F1/NFATC3/TNFRSF10A/PIK3R2/PYCARD/MAPK1/TRAF6/ATF6/KRAS/PPP3CB/TAB2/GSK3B/PLCB1/JAK2/CASP7/PIK3R3/CAMK2D/MAPK8/XBP1	6.1742375202188
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	70/1774	196/9376	1.88758254147206	HLA-B/TCF7L2/NFKBIA/FOS/CDKN1A/HLA-A/CXCL2/CCR1/MAP1LC3B/CXCL3/PIK3R1/MAPK3/IL6ST/JUN/UBB/ITPR2/TCF7/ZFP36/GNG12/PPP3CA/ICAM1/EP300/STAT2/NFKB1/CREBBP/IFNAR1/IFNGR1/PREX1/ITPR3/RCAN1/PPP3R1/PIK3CA/HIF1A/RAF1/MAP2K1/UBC/MAP2K7/FADD/CASP3/CD86/HLA-F/STAT1/HLA-E/SYK/EIF2AK2/TBK1/RB1/TCF7L1/MAP2K4/CLEC2B/IKBKE/HCK/PTGS2/CREB1/STAT3/NFATC3/MTOR/PIK3R2/GNG10/GNG4/MAPK1/ATG14/KRAS/PPP3CB/GSK3B/TLR3/JAK2/PIK3R3/VEGFA/MAPK8	6.06616137679025
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	66/1774	181/9376	1.92721134621014	HLA-DRA/CD74/HLA-DPA1/HLA-DPB1/HLA-DRB1/FCER1G/CTSS/HLA-DQB1/CTSD/MAPK3/HLA-DQA1/TGFB2/IL1B/MRC2/ITGB2/IL10RB/FCGR3A/CEBPB/HLA-DMB/PPP3CA/CAMK2G/HLA-DMA/LSP1/LAMP2/ATP6V0D1/EP300/RAB5A/NFKB1/NOS2/PLK3/KSR1/CREBBP/HLA-DRB5/TNF/IL10RA/IFNGR1/HLA-DQA2/RAB5B/ATP6V1H/CD14/ITGAX/PPP3R1/RAF1/ATP6V0A1/FCGR2A/FCGR1A/NFYC/FADD/ATP6AP1/CASP3/ITGAM/STAT1/SYK/CORO1A/CREB1/BCL10/PLA2R1/MAPK1/TRAF6/PPP3CB/JAK2/ARHGEF12/EEA1/CAMK2D/MAPK8/NFYA	6.08472102612815
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	84/1774	250/9376	1.77583765501691	HLA-B/HLA-A/HSPA1B/ASAP3/GRK4/CLTB/PARD6G/CXCR4/TGFBR1/MDM2/IGF2R/VPS36/IL2RB/SH3KBP1/SMAP2/HSPA8/VPS4B/LDLR/IST1/RAB5A/SH3GL1/ARAP1/IQSEC1/RABEP1/CHMP3/EHD3/SH3GLB1/CHMP4C/CYTH2/WIPF2/RAB5B/FGFR3/HSPA6/ARFGAP2/CHMP1A/VPS35/DNM2/VPS4A/AP2A2/ARF1/ASAP1/CYTH3/STAMBP/PDCD6IP/TSG101/USP8/AP2B1/HLA-F/AGAP3/HLA-E/ARFGAP1/ZFYVE9/SMAD2/SNX4/HGS/NEDD4/GBF1/CYTH1/VPS37B/SNX1/RAB22A/RAB11B/PLD1/EPS15L1/RAB11FIP4/ARFGEF2/GIT1/VTA1/NEDD4L/TRAF6/GIT2/EPN2/RAB11FIP1/IL2RG/EEA1/EPS15/WWP1/CHMP7/ZFYVE27/ARFGEF1/ITCH/VPS37C/ACAP3/CHMP6	6.00619100925767
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	65/1774	180/9376	1.90855568082175	HLA-B/HLA-DRA/CD74/HLA-DPA1/NFKBIA/TAPBPL/HLA-DPB1/HLA-DRB1/HLA-A/TAPBP/PIK3R1/HLA-DQB1/HLA-DQA1/IL1B/HLA-DMB/ITGA5/HLA-DMA/STAT2/NFKB1/SRSF2/IFNAR1/TNFRSF14/HLA-DRB5/TNF/OAS2/IFNGR1/HLA-DQA2/SRSF6/TSC1/CCL2/EIF2B1/CCL5/PIK3CA/TAP1/MAP3K7/FADD/CASP3/HLA-F/STAT1/BIRC3/IFIH1/HCFC1/HLA-E/SYK/EIF2AK2/RNASEL/TBK1/IKBKE/BIRC2/PPP1CC/RHEB/TSC2/POU2F1/ZC3HAV1/MTOR/PIK3R2/TRAF6/PILRB/TAB2/PTPN11/TLR3/JAK2/PIK3R3/MAVS/HCFC2	5.94547877106626
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	52/1774	133/9376	2.06640615066415	CDKN1A/FOXO1/PIK3R1/MAPK3/TGFB2/FOXO3/FBXO32/PRKAG2/GADD45A/IRS2/HOMER3/GABARAPL2/TGFBR1/MDM2/CCNG2/GABARAP/BCL6/SOS1/BCL2L11/EP300/USP7/PLK2/GABARAPL1/PDPK1/PLK3/CREBBP/TNFSF10/RBL2/SMAD4/CAT/INSR/CDKN2B/PIK3CA/HOMER1/RAF1/MAP2K1/SGK2/SIRT1/GADD45B/PRKAB2/KLF2/SGK3/ATM/STAT3/PRKAA1/PIK3R2/MAPK1/KRAS/NLK/PIK3R3/MAPK8/CDKN1B	5.9832961401339
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	77/1774	227/9376	1.79278764731883	HLA-B/NFKBIA/TAPBPL/CDKN1A/CDKN2A/HLA-A/CCL3/CCR1/TAPBP/PIK3R1/MAPK3/IL1B/CCL4/GNAQ/CREB5/CXCR4/AKAP13/ITPR2/IL10RB/MDM2/GNG12/PPP3CA/SOS1/NFKB1/CREB3L2/ATF4/TNF/IL10RA/PTK2/TSC1/ITPR3/CCL2/CCL5/PPP3R1/PTGER4/GNA11/PIK3CA/ATF6B/SP1/RAF1/MAP2K1/TAP1/CRKL/FADD/GNA13/CASP3/HLA-F/HLA-E/TBK1/RB1/CRK/RIPK1/RAC2/ROCK2/PTGS2/RHEB/TSC2/CREB1/STAT3/NFATC3/ATF2/MTOR/PIK3R2/GNG10/GNG4/MAPK1/KRAS/ITGAV/PPP3CB/GSK3B/PLCB1/ARHGEF12/RPS6KB1/PIK3R3/CREB3L4/VEGFA/ADCY7	5.84092329213022
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	58/1774	155/9376	1.9776993853875	HLA-B/HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-DRB1/HLA-A/CTSS/HLA-DQB1/HLA-DQA1/MRC2/ITGB2/ITGB1/FCGR3A/HLA-DMB/MSR1/ITGA5/ATP6V1G1/OLR1/HLA-DMA/LAMP2/CTSL/DYNC1I2/CD36/ATP6V0D1/RAB5A/ATP6V0E1/NCF2/STX7/HLA-DRB5/SCARB1/HLA-DQA2/RAB5B/ATP6V1H/CD14/CYBB/ATP6V1A/STX12/ATP6V1D/TAP1/ATP6V0A1/FCGR2A/FCGR1A/ATP6AP1/ITGAM/MARCO/HLA-F/HLA-E/PIKFYVE/RILP/CORO1A/HGS/ATP6V1E1/DYNC1LI2/ATP6V1B2/PLA2R1/ITGAV/EEA1/ITGA2	5.92898966838624
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	71/1774	204/9376	1.83946769237571	TIMP3/FN1/IGF2/CDKN1A/PIK3R1/MAPK3/VAV3/TGFB2/DDX5/ITGB1/ITPR2/HSPG2/MDM2/ITGA5/MMP9/CAMK2G/WNT7A/CTSL/GPC3/TIAM1/SOS1/ERBB3/HCLS1/PDPK1/TNF/CD44/PTK2/ITPR3/FRS2/SLC9A1/PIK3CA/HBEGF/FZD6/FZD1/HIF1A/RAF1/MAP2K1/MET/CASP3/ERBB2/WNT6/FZD7/SMAD2/VAV2/ROCK2/NUDT16L1/PPP1CC/FZD8/STAT3/PTCH1/GAB1/RRAS2/PPP1R12B/WNT2B/SDC2/MTOR/PIK3R2/PLAU/MAPK1/KRAS/ITGAV/SDC4/PTPN11/ARHGEF12/RPS6KB1/PIK3R3/WNT5B/CAMK2D/VEGFA/PTPN6/ITGA2	5.85579090227475
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	60/1774	163/9376	1.94548384642519	NFKBIA/FOS/CDKN1A/CCNE1/PIK3R1/MAPK3/TGFB2/CREB5/JUN/MAP2K3/TGFBR1/HSPG2/MMP9/YWHAZ/EGR3/STAT6/SOS1/EP300/STAT2/NFKB1/CREB3L2/ATF4/CREBBP/DDB1/IFNAR1/TNF/SMAD4/PIK3CA/ATF6B/STAT4/RAF1/MAP2K1/MAP3K7/MAP2K7/FADD/ATP6AP1/CASP3/STAT1/MAP3K1/IFIH1/TBK1/RB1/MAP2K4/EGR2/IKBKE/CREB1/STAT3/NFATC3/ATF2/PIK3R2/MAPK1/TRAF6/KRAS/TAB2/TLR3/JAK2/PIK3R3/CREB3L4/MAVS/MAPK8	5.8822827079281
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	71/1774	205/9376	1.83049467924217	HLA-B/HLA-DRA/HLA-DPA1/NFKBIA/TAPBPL/HLA-DPB1/HLA-DRB1/VIM/CDKN1A/HLA-A/TAPBP/CCNE1/PIK3R1/HLA-DQB1/HLA-DQA1/GADD45A/JUN/MAP2K3/MDM2/HLA-DMB/HLA-DMA/TNFAIP3/ICAM1/ENTPD1/BCL2L11/CD40/USP7/STAT2/BLNK/NFKB1/IFNAR1/HLA-DRB5/TNF/OAS2/CD44/HLA-DQA2/PIK3CA/CXCL10/TAP1/MAP3K7/MAP2K7/GADD45B/FADD/CASP3/HLA-F/STAT1/HLA-E/SYK/EIF2AK2/TBK1/RB1/RIPK1/MAP2K4/IKBKE/NFKBIE/SAP30L/STAT3/ITGAL/NEDD4/HDAC2/RBPJ/PIK3R2/NCOR2/TRAF6/NFKB2/TAB2/SIN3A/PIK3R3/MAVS/MAPK8/CDKN1B	5.80769701735112
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	54/1774	142/9376	2.00987662162377	TYROBP/NFKBIA/FOS/LILRB3/FOSB/JUND/PIK3R1/MAPK3/TGFB2/IL1B/TREM2/JUN/TGFBR1/ITPR2/FCGR3A/PPP3CA/NCF2/STAT2/BLNK/NFKB1/SPI1/SQSTM1/IFNAR1/TNF/IFNGR1/CYLD/ITPR3/SOCS1/TMEM64/PPP3R1/PIK3CA/FOSL2/JUNB/MAP2K1/LILRB4/CSF1R/MAP3K7/FCGR2A/MAP2K7/LCP2/FCGR1A/STAT1/SYK/CREB1/PIK3R2/ATP2A2/MAPK1/TRAF6/NFKB2/PPP3CB/TAB2/SIRPA/PIK3R3/MAPK8	5.85755086985588
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	37/1774	83/9376	2.35606688309042	JARID2/L3MBTL3/DCAF7/EP300/USP7/SKP1/PHC2/LCOR/CREBBP/USP16/BMI1/RBBP4/MTF2/YAF2/MGA/FBRSL1/SUZ12/CBX4/ASXL2/UBE2D1/KDM2A/HCFC1/AEBP2/L3MBTL2/FBRS/E2F6/FOXK2/UBE2D4/HDAC2/SCML1/RING1/PHC3/RBBP7/PHF1/TEX10/OGT/PHC1	5.9943307305882
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	94/1774	300/9376	1.65603908305148	IGF2/FOS/IL1RAP/RASGRF2/HSPA1B/JUND/MAPK3/DUSP1/TGFB2/IL1B/EFNA1/GADD45A/JUN/DUSP2/MAP2K3/TGFBR1/HSPB1/GNG12/PPP3CA/DUSP9/HSPA8/MAP3K2/SOS1/ERBB3/MAPK8IP2/RASA1/RASGRF1/NFKB1/EREG/ATF4/RAPGEF2/TNF/MAP3K5/PAK2/DUSP4/FGFR3/HSPA6/CD14/TAOK1/INSR/PPP3R1/TAOK3/STK3/PPM1A/RAF1/MAP2K1/CSF1R/MAP3K7/CRKL/MAP2K7/MET/FLT4/GADD45B/PTPRR/CASP3/ERBB2/MAP3K1/CRK/SRF/RPS6KA3/MAP2K4/NF1/EFNA5/MAP3K3/RAC2/DUSP8/PPM1B/DDIT3/ELK4/RRAS2/NFATC3/DUSP7/MAP3K13/RPS6KA5/ATF2/MAP3K11/MAP4K3/MAPK1/TRAF6/NFKB2/KRAS/MAPK8IP3/PPP3CB/TAB2/RASA2/CACNA1G/DUSP3/NLK/DUSP10/RPS6KA4/VEGFA/MAPK8/MAP3K9/MAP2K5	5.57881050469476
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	52/1774	137/9376	2.00607312436738	NFKBIA/FOS/CSF2RB/CTSS/CTSB/PIK3R1/CTSD/MAPK3/BCL2A1/GADD45A/JUN/ITPR2/CTSO/CTSL/MCL1/BCL2L11/PARP4/XIAP/NFKB1/ATF4/PDPK1/DFFB/TNF/MAP3K5/TNFSF10/ITPR3/CAPN2/PMAIP1/ENDOG/PIK3CA/RAF1/MAP2K1/EIF2AK3/BBC3/GADD45B/FADD/CASP3/BIRC3/CFLAR/CASP2/RIPK1/BIRC2/ATM/DDIT3/TNFRSF10A/PIK3R2/MAPK1/KRAS/CASP7/PIK3R3/CTSF/MAPK8	5.73028023081392
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	38/1774	93/9376	2.15955680013577	HLA-DRA/HLA-DPA1/NFKBIA/FOS/HLA-DPB1/HLA-DRB1/GATA3/HLA-DQB1/MAPK3/HLA-DQA1/JUN/NOTCH2/HLA-DMB/MAML2/IL2RB/PPP3CA/HLA-DMA/STAT6/JAG2/NFKB1/HLA-DRB5/IFNGR1/HLA-DQA2/PPP3R1/STAT4/CD4/STAT1/MAF/NFKBIE/MAML1/NFATC3/RBPJ/MAPK1/IL12RB1/PPP3CB/IL2RG/JAK2/MAPK8	5.42859996419251
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	46/1774	122/9376	1.99279206017706	CSH2/CSH1/IGFBP3/FOS/PIK3R1/MAPK3/GNAQ/CREB5/IRS2/MAP2K3/ITPR2/SOS1/EP300/CREB3L2/ATF4/CREBBP/CSHL1/PTK2/ITPR3/SOCS1/GNA11/PIK3CA/ATF6B/JUNB/RAF1/MAP2K1/CRKL/STAT1/MAP3K1/CRK/MAP2K4/CREB1/STAT3/ATF2/MTOR/PIK3R2/MAPK1/KRAS/GH2/GSK3B/PLCB1/JAK2/PIK3R3/CREB3L4/ADCY7/MAPK8	5.33177699306088
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	41/1774	105/9376	2.06375691200945	NFKBIA/FCER1G/PIK3R1/MAPK3/IL1B/JUN/ITPR2/MDM2/IRF1/PPP3CA/LSP1/EGR3/STAT2/NFKB1/PLK3/KSR1/TNF/CYLD/ITPR3/PPP3R1/PIK3CA/RAF1/STAT1/SYK/EGR2/IKBKE/PTGS2/RRAS2/NFATC3/BCL10/PIK3R2/PYCARD/MAPK1/NFKB2/KRAS/PPP3CB/BCL3/PTPN11/ARHGEF12/PIK3R3/MAPK8	5.29507684669102
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	55/1774	157/9376	1.85151408526558	ABCA1/MAPK3/C1QB/C1QA/DUSP2/LRP1/CEBPB/ADAM10/CAMK2G/RXRA/CD36/TMEM30A/ADAM17/RAB5A/C1QC/DUSP4/ANO6/RAB5B/HAVCR2/PTK2/RAB14/PTGER4/STAB2/HIF1A/MAP2K1/CRKL/SIRT1/CASP3/PLA2G15/CRK/TGFBRAP1/PPARD/TMEM30B/DUSP8/PTGS2/CREB1/VPS8/NFATC3/DUSP7/ALOX5/ATP11C/ATP2A2/MFGE8/MAPK1/VPS11/ITGAV/GPR132/LIPA/PTPN11/JAK2/CASP7/SIRPA/CAMK2D/VPS41/PTPN6	5.19754512123975
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	38/1774	95/9376	2.1140924464487	HLA-DRA/HLA-DPA1/FOS/HLA-DPB1/HLA-DRB1/CCL3/CXCL2/CXCL3/HLA-DQB1/HLA-DQA1/TGFB2/IL1B/JUN/ITGB2/HLA-DMB/ATP6V1G1/HLA-DMA/CTSL/CCL20/ICAM1/ATP6V0D1/ATP6V0E1/HLA-DRB5/TNF/HLA-DQA2/ATP6V1H/CCL2/CCL5/ATP6V1A/ATP6V1D/TNFSF13B/ATP6V0A1/ATP6AP1/CD86/ATP6V1E1/ITGAL/ATP6V1B2/VEGFA	5.2721063135031
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	30/1774	68/9376	2.33171961005372	TCF7L2/PIM1/PIK3R1/MAPK3/BCL2A1/TCF7/CEBPA/SOS1/NFKB1/SPI1/PER2/CD14/PIK3CA/RUNX1/RAF1/MAP2K1/CSF1R/JUP/FCGR1A/ITGAM/TCF7L1/PPARD/RARA/STAT3/MTOR/PIK3R2/MAPK1/KRAS/RPS6KB1/PIK3R3	5.32399424433443
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	37/1774	93/9376	2.10272635802694	COL4A1/FN1/COL4A2/NFKBIA/CDKN1A/CCNE1/PIK3R1/LAMC1/ITGA6/GADD45A/ITGB1/RXRA/XIAP/NFKB1/NOS2/RXRB/LAMC2/PTK2/CDKN2B/PIK3CA/LAMA5/CKS2/CKS1B/GADD45B/CASP3/BIRC3/RB1/BIRC2/PTGS2/PIK3R2/TRAF6/ITGAV/PIK3R3/ITGA3/CDKN1B/BIRC7/ITGA2	5.16254164263297
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	36/1774	90/9376	2.1140924464487	FOXO1/PIK3R1/FOXO3/PRKAG2/CREB5/IRS2/NFKB1/CREB3L2/ATF4/SESN1/TSC1/CAT/INSR/PIK3CA/ATF6B/SIRT1/PRKAB2/SESN3/RHEB/TSC2/CREB1/PRKAA1/ATF2/EHMT1/MTOR/PIK3R2/EHMT2/SESN2/KRAS/RPS6KB1/RB1CC1/ATG13/PIK3R3/CREB3L4/ADCY7/CAMKK2	5.13010977226838
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	50/1774	144/9376	1.83514969309783	TCF7L2/NFKBIA/FOXO1/CXCL2/CXCL3/C1QB/C1QA/IL1B/FOXO3/PRKAG2/MAP2K3/ACOX1/TCF7/LY96/FASN/NFKB1/C1QC/TNF/MAP3K5/TRA2A/C2/CD14/MLYCD/C5AR1/SREBF1/MAP3K7/LPIN2/LPIN1/SIRT1/MAP2K7/FADD/CASP3/C3AR1/ALDH9A1/ACADVL/TBK1/PRKAB2/RIPK1/TCF7L1/MAP2K4/IKBKE/PPARA/PRKAA1/TRAF6/TAB2/GSK3B/NOX4/MAPK8/ACOX3/CAMKK2	4.87861096225619
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	33/1774	82/9376	2.126983254049	HLA-B/HLA-DRA/CD74/HLA-DPA1/TAPBPL/HLA-DPB1/HLA-DRB1/HLA-A/CTSS/HSPA1B/CTSB/TAPBP/HLA-DQB1/HLA-DQA1/HLA-DMB/HSP90AB1/HLA-DMA/CTSL/HSPA8/LGMN/HSP90AA1/HLA-DRB5/TNF/HLA-DQA2/HSPA6/TAP1/CD4/NFYC/HLA-F/HLA-E/CREB1/IFI30/NFYA	4.95132653210427
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	36/1774	94/9376	2.02413106574876	NFKBIA/FOS/IL17RE/CXCL2/FOSB/JUND/CXCL3/MAPK3/IL1B/JUN/S100A9/CEBPB/MMP9/HSP90AB1/CCL20/TNFAIP3/HSP90AA1/NFKB1/TNF/CCL2/S100A8/MAPK6/CXCL10/MAP3K7/FADD/CASP3/TBK1/IKBKE/IL17B/PTGS2/TRAF3IP2/MAPK1/TRAF6/TAB2/GSK3B/MAPK8	4.82055673045402
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	34/1774	87/9376	2.06549262009356	TCF7L2/FOS/CDKN1A/PIK3R1/MAPK3/TGFB2/GADD45A/JUN/TGFBR1/TCF7/RALGDS/SOS1/BCL2L11/EREG/AXIN2/SMAD4/PMAIP1/PIK3CA/RAF1/MAP2K1/BBC3/GADD45B/CASP3/SMAD2/TCF7L1/RAC2/MTOR/PIK3R2/MAPK1/KRAS/GSK3B/RPS6KB1/PIK3R3/MAPK8	4.82307598658187
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	35/1774	91/9376	2.03278119850837	NFKBIA/FOS/LILRB3/PIK3R1/MAPK3/VAV3/JUN/DAPP1/PPP3CA/SOS1/BLNK/NFKB1/CD22/PPP3R1/PIK3CA/PIK3AP1/RAF1/MAP2K1/LILRB4/SYK/NFKBIE/RAC2/VAV2/NFATC3/BCL10/PIK3R2/MAPK1/CD72/KRAS/PPP3CB/GSK3B/PIK3R3/BANK1/INPPL1/PTPN6	4.7822973798541
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	64/1774	205/9376	1.65002337283801	HLA-B/NFKBIA/CDKN1A/CDKN2A/HLA-A/REL/CCNE1/PIK3R1/MAPK3/YWHAG/IL6ST/CREB5/JUN/MDM2/YWHAZ/EGR3/ATP6V0D1/EP300/USP7/NFKB1/CREB3L2/VAC14/ATF4/CHD4/CREBBP/HNRNPK/DDB1/RBL2/PMAIP1/CDKN2B/PIK3CA/ATF6B/SCIN/TBP/GTF2B/UBE3A/CASP3/HLA-F/DNAJA3/HLA-E/SYK/EIF2AK2/RB1/SRF/DLG1/EGR2/GSN/CREB1/STAT3/UBR4/HDAC2/POLB/ATF2/RBPJ/PIK3R2/MRPS18B/MAPK1/NFKB2/KRAS/RASA2/PIK3R3/CREB3L4/GTF2E1/CDKN1B	4.54565080065855
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	43/1774	122/9376	1.86282736060029	MED13L/FOXO1/PIK3R1/MAPK3/NOTCH2/PLCD3/MDM2/DIO2/THRB/NCOA1/RXRA/EP300/NCOA2/PDPK1/CREBBP/RXRB/MED13/RCAN1/NCOR1/SLC9A1/PIK3CA/ATP1B1/HIF1A/RAF1/MAP2K1/MED17/STAT1/MED1/MED4/RHEB/TSC2/HDAC2/MTOR/PIK3R2/ATP2A2/MAPK1/KRAS/ITGAV/GSK3B/PLCB1/SIN3A/PIK3R3/MED12	4.63380324517466
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	47/1774	138/9376	1.8000424815777	FN1/NFKBIA/FOS/PIK3R1/MAPK3/VAV3/IL1B/GNAQ/JUN/ITGB1/MAP2K3/ITGA5/ARHGEF7/NFKB1/TNF/SKAP2/WIPF2/PTK2/CCL2/PKN2/PIK3CA/MAP2K1/MAP3K7/CRKL/CD4/FCGR2A/MAP2K7/LCP2/BAIAP2/TBK1/CRK/RPS6KA3/MAP2K4/RAC2/VAV2/ROCK2/NFATC3/PIK3R2/PYCARD/MAPK1/TRAF6/GIT2/TAB2/GSK3B/ARHGEF12/PIK3R3/MAPK8	4.5736415625192
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	34/1774	90/9376	1.99664286609044	NFKBIA/FOS/PIK3R1/MAPK3/JUN/MAP2K3/BATF3/PPP3CA/NFKB1/IFNGR1/PPP3R1/PIK3CA/CSNK2A2/CD274/HIF1A/RAF1/MAP2K1/CD4/STAT1/NFKBIE/MAP3K3/STAT3/NFATC3/MTOR/PIK3R2/MAPK1/TRAF6/KRAS/PPP3CB/PTPN11/JAK2/RPS6KB1/PIK3R3/PTPN6	4.58928459939752
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	51/1774	155/9376	1.73901152853039	TCF7L2/CDKN1A/CDKN2A/CCNE1/MAPK3/GNAQ/CREB5/ITPR2/TCF7/CAMK2G/WNT7A/LDLR/CREB3L2/ATF4/CRH/AHR/AXIN2/SCARB1/ITPR3/GNA11/CDKN2B/ATF6B/FZD6/SP1/FZD1/MAP2K1/USP8/WNT6/FZD7/ARMC5/RB1/TCF7L1/FZD8/CREB1/ATF2/WNT2B/RBBP5/PDE8A/KMT2D/MAPK1/CACNA1G/GSK3B/PLCB1/DVL2/CREB3L4/WNT5B/CAMK2D/RASD1/ADCY7/CDKN1B/NCEH1	4.48153264997543
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	26/1774	62/9376	2.21638724224461	TLE3/TLE4/TLE6/NOTCH2/NCSTN/MAML2/DTX4/ADAM17/JAG2/ATXN1/EP300/CREBBP/SPEN/PSEN1/CTBP1/ATXN1L/DTX3L/NUMB/LFNG/MAML1/NRARP/HDAC2/RBPJ/NCOR2/DVL2/ITCH	4.64192477059162
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	24/1774	56/9376	2.26509904976647	NFKBIA/EEF1A1/CXCL2/HSPA1B/CXCL3/IL1B/ITGB2/HSPA8/CLK1/NFKB1/TNF/RAB1A/HSPA6/CD14/ARF1/RAB1B/CASP3/ITGAM/EEF1G/CLK4/PYCARD/NFKB2/CASP7/HBS1L	4.58679256824352
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	28/1774	70/9376	2.1140924464487	HLA-B/HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-DRB1/HLA-A/DAG1/HLA-DQB1/HLA-DQA1/ITGB2/HLA-DMB/HLA-DMA/EIF4G2/ICAM1/CD40/HLA-DRB5/HLA-DQA2/SNTB1/SGCE/CASP3/CD86/ABL2/HLA-F/HLA-E/EIF4G1/RAC2/SSPN/ITGAL	4.51946720096677
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	42/1774	122/9376	1.8195057940747	FOXO1/PIK3R1/FOXO3/PRKAG2/CREB5/PPP2CB/IRS2/FBP1/CD36/FASN/CREB3L2/PDPK1/TSC1/RAB14/INSR/MLYCD/PIK3CA/STRADB/SREBF1/MAP3K7/HMGCR/SIRT1/PPP2R3C/PPP2R5E/PRKAB2/RHEB/TSC2/CREB1/PRKAA1/PPP2CA/TBC1D1/RAB11B/MTOR/PIK3R2/PPP2R2D/CAB39/PFKFB4/RPS6KB1/PIK3R3/EEF2K/CREB3L4/CAMKK2	4.40114532921258
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	54/1774	170/9376	1.67883811923868	IGF2/TCF7L2/GSTT1/CDKN1A/CDKN2A/BRD7/PIK3R1/MAPK3/TGFB2/GADD45A/HMOX1/TGFBR1/TCF7/WNT7A/SOS1/SMARCE1/ARID1A/AXIN2/SMAD4/SMARCD2/PBRM1/PIK3CA/SMARCD1/FZD6/FZD1/RAF1/MAP2K1/MET/GADD45B/WNT6/FZD7/SMAD2/RB1/TCF7L1/NFE2L2/ARID1B/GSTM4/FZD8/FRAT1/TXNRD3/GAB1/FRAT2/DPF1/WNT2B/MTOR/PIK3R2/MAPK1/KRAS/GSK3B/RPS6KB1/PIK3R3/DVL2/WNT5B/ARID2	4.31473085373636
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	28/1774	71/9376	2.08431649649872	NFKBIA/CXCL2/CXCL3/TJP1/JUN/JAM2/ADAM10/ATP6V1G1/ADAM17/ATP6V0D1/ATP6V0E1/NFKB1/ATP6V1H/CCL5/ATP6V1A/HBEGF/ATP6V1D/CSK/ATP6V0A1/MET/ATP6AP1/CASP3/MAP2K4/ATP6V1E1/ATP6V1B2/GIT1/PTPN11/MAPK8	4.43022276082741
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	41/1774	120/9376	1.80578729800827	ARHGDIB/NFKBIA/PIK3R1/MAPK3/FOXO3/JUN/CAMK2G/SOS1/NFKB1/ATF4/PDPK1/MAP3K5/SH2B3/FRS2/PIK3CA/RAF1/MAP2K1/KIDINS220/CRKL/PSEN1/MAP2K7/MAGED1/MAP3K1/RAPGEF1/CRK/RPS6KA3/NFKBIE/MAP3K3/SH2B1/GAB1/RPS6KA5/PIK3R2/MAPK1/TRAF6/KRAS/GSK3B/PTPN11/PIK3R3/CAMK2D/MAPK8/MAP2K5	4.2913889687531
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	32/1774	86/9376	1.96659762460345	CDKN1A/PIK3R1/MAPK3/JUN/CAMK2G/SOS1/ERBB3/EREG/PAK2/PTK2/PIK3CA/HBEGF/RAF1/MAP2K1/CRKL/MAP2K7/ERBB2/ABL2/NCK1/CRK/MAP2K4/GAB1/MTOR/PIK3R2/MAPK1/KRAS/GSK3B/RPS6KB1/PIK3R3/CAMK2D/MAPK8/CDKN1B	4.34996342601172
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	36/1774	101/9376	1.88384475426122	COL4A1/FN1/COL4A2/SERPINE1/FOXO1/PIM1/PIK3R1/MAPK3/TGFB2/IL1B/JUN/TGFBR1/PLCD3/EGR1/ICAM1/NFKB1/TNF/SMAD4/CCL2/CYBB/PRKCE/PIK3CA/CASP3/STAT1/SMAD2/STAT3/PIK3R2/MAPK1/KRAS/NOX4/PLCB1/JAK2/PIK3R3/VEGFA/MAPK8/CDKN1B	4.31398101704719
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	38/1774	109/9376	1.84255763681309	SPP1/NFKBIA/FOS/CCL3/PIK3R1/MAPK3/IL1B/CCL4/JUN/MAP2K3/LY96/CD40/STAT2/NFKB1/IFNAR1/TNF/CD14/CCL5/PIK3CA/CXCL9/CXCL10/MAP2K1/MAP3K7/MAP2K7/FADD/CD86/STAT1/TBK1/RIPK1/MAP2K4/IKBKE/PIK3R2/MAPK1/TRAF6/TAB2/TLR3/PIK3R3/MAPK8	4.27407166727108
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	54/1774	173/9376	1.64972531948309	HLA-DRA/HLA-DPA1/NFKBIA/HLA-DPB1/HLA-DRB1/PIK3R1/HLA-DQB1/MAPK3/HLA-DQA1/IL1B/DNAJB1/HLA-DMB/HLA-DMA/ICAM1/EP300/STAT2/NFKB1/CREBBP/IFNAR1/HLA-DRB5/TNF/OAS2/TNFSF10/IFNGR1/HLA-DQA2/KPNA6/HNRNPUL1/CCL2/CCL5/TRIM25/PIK3CA/CXCL10/RAF1/MAP2K1/FADD/CASP3/PABPN1/STAT1/IFIH1/EIF2AK2/RNASEL/TBK1/IKBKE/TNFRSF10A/RAB11B/MX2/PIK3R2/PYCARD/MAPK1/TLR3/JAK2/PIK3R3/MAVS/MX1	4.16664639359652
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	55/1774	178/9376	1.63307703026234	NOTUM/SFRP1/TCF7L2/TLE3/TLE4/TLE6/JUN/ANKRD6/TCF7/BAMBI/PPP3CA/CAMK2G/WNT7A/EP300/SKP1/CREBBP/DAAM1/AXIN2/SMAD4/MMP7/PPP3R1/FZD6/CSNK2A2/FZD1/TBL1XR1/MAP3K7/PSEN1/SERPINF1/SIRT1/WNT6/RYK/FZD7/CTBP1/SIAH1/TCF7L1/PPARD/RAC2/FBXW11/ROCK2/FZD8/FRAT1/FRAT2/NFATC3/WNT2B/CCAR2/ROR1/PPP3CB/GSK3B/PLCB1/NLK/CBY1/DVL2/WNT5B/CAMK2D/MAPK8	4.11925206686009
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	41/1774	122/9376	1.77618422754912	NFKBIA/FOS/PIK3R1/MAPK3/VAV3/PPP2CB/JUN/PPP3CA/SOS1/NFKB1/PDPK1/TNF/PAK2/PTPRC/PPP3R1/PIK3CA/RAF1/MAP2K1/MAP3K7/CD4/MAP2K7/LCP2/PPP2R3C/PPP2R5E/NCK1/DLG1/NFKBIE/VAV2/PPP2CA/NFATC3/BCL10/PIK3R2/PPP2R2D/MAPK1/KRAS/PPP3CB/GSK3B/PTPN11/PIK3R3/MAPK8/PTPN6	4.16848741325051
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	36/1774	103/9376	1.84726524446974	NFKBIA/SERPINE1/FOS/CCL3/PIK3R1/MAPK3/C1QB/C1QA/TGFB2/IL1B/GNAQ/PPP2CB/JUN/TGFBR1/NFKB1/NOS2/C1QC/TNF/IFNGR1/CCL2/CCL5/GNAL/GNA11/PIK3CA/FADD/CFLAR/SMAD2/MAP2K4/PPP2CA/PIK3R2/PPP2R2D/MAPK1/TRAF6/PLCB1/PIK3R3/MAPK8	4.1766336910947
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	29/1774	77/9376	1.99054158918871	CDKN1A/CDKN2A/PIK3R1/MAPK3/TGFB2/GADD45A/TGFBR1/RALGDS/NFKB1/SMAD4/PIK3CA/RAF1/MAP2K1/GADD45B/ERBB2/STAT1/SMAD2/RB1/RAC2/STAT3/PLD1/MTOR/PIK3R2/MAPK1/KRAS/RPS6KB1/PIK3R3/VEGFA/MAPK8	4.21597926946705
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	29/1774	77/9376	1.99054158918871	NFKBIA/CDKN1A/CDKN2A/PIK3R1/MAPK3/TGFB2/GADD45A/TGFBR1/MDM2/SOS1/NFKB1/SMAD4/PIK3CA/RUNX1/RAF1/MAP2K1/CRKL/GADD45B/CTBP1/RB1/CRK/HDAC2/PIK3R2/MAPK1/BCR/KRAS/PTPN11/PIK3R3/CDKN1B	4.21597926946705
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	27/1774	70/9376	2.03858914478982	EPAS1/CDKN1A/PIK3R1/MAPK3/TGFB2/JUN/SOS1/EP300/CREBBP/PAK2/PIK3CA/VHL/HIF1A/RAF1/MAP2K1/CRKL/MET/RAPGEF1/CRK/ARNT2/GAB1/PIK3R2/MAPK1/KRAS/PTPN11/PIK3R3/VEGFA	4.2131778113387
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	60/1774	201/9376	1.5776809301856	HPGD/ASPSCR1/IGFBP3/CDKN1A/FOXO1/REL/BCL2A1/GADD45A/DDX5/MDM2/NFKBIZ/CEBPB/MMP9/IL2RB/BCL6/CEBPA/RXRA/FUS/CD40/NFKB1/SPI1/RXRB/CCNT1/BMI1/FUT8/PER2/PTK2/SMAD1/CD14/NUPR1/NCOR1/RUNX1/NR4A3/SP1/CSF1R/JUP/MET/FCGR1A/JMJD1C/GADD45B/ITGAM/ETV6/CD86/BIRC3/ARNT2/BIRC2/MAF/ATM/DDIT3/RARA/ELK4/ELANE/CCNT2/SIX4/HDAC2/SUPT3H/PLAU/SIN3A/CDKN1B/DOT1L	3.99927747284889
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	36/1774	105/9376	1.81207923981317	NFKBIA/CXCL2/CXCL3/IL1B/CCL4/BCL2A1/GADD45A/LY96/TNFAIP3/ICAM1/CD40/XIAP/BLNK/NFKB1/TNF/CYLD/CD14/TRIM25/CSNK2A2/TNFSF13B/EDARADD/MAP3K7/GADD45B/BIRC3/CFLAR/SYK/RIPK1/BIRC2/ATM/PTGS2/BCL10/PLAU/TRAF6/NFKB2/TAB2/EDA2R	4.04229756993108
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	37/1774	109/9376	1.79406927794959	PTPRF/NFKBIA/FOXO1/PIK3R1/PRKAG2/CREB5/IRS2/CD36/PPP1R3D/NFKB1/CREB3L2/PDPK1/TNF/MLXIP/SLC27A1/PRKCE/INSR/PIK3CA/SREBF1/PRKAB2/RPS6KA3/PPP1CC/CREB1/STAT3/PPARA/PRKAA1/MTOR/PIK3R2/PPARGC1B/GFPT1/OGT/GSK3B/PTPN11/RPS6KB1/PIK3R3/CREB3L4/MAPK8	4.02810306909321
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	49/1774	158/9376	1.63909066259472	PIK3R1/MAPK3/ATP6V1G1/WNT7A/SOS1/PDPK1/TNF/DDIT4/RRAGC/ATP6V1H/TSC1/INSR/ATP6V1A/PIK3CA/FZD6/ATP6V1D/FZD1/RAF1/MAP2K1/STRADB/LPIN2/LPIN1/WNT6/SLC38A9/FZD7/RPS6KA3/FZD8/RHEB/ATP6V1E1/TSC2/RICTOR/FNIP1/PRKAA1/WNT2B/MTOR/ATP6V1B2/PIK3R2/ULK2/SESN2/MAPK1/CAB39/KRAS/GRB10/GSK3B/RPS6KB1/PIK3R3/DVL2/WNT5B/TELO2	3.91355261742361
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	36/1774	106/9376	1.79498415264513	TCF7L2/NFKBIA/CDKN1A/FOXO1/CCNE1/PIK3R1/MAPK3/CREB5/TCF7/MDM2/MMP9/HSP90AB1/SOS1/EP300/HSP90AA1/NFKB1/CREB3L2/ATF4/PDPK1/CREBBP/PIK3CA/RAF1/MAP2K1/ERBB2/RB1/TCF7L1/CREB1/MTOR/PIK3R2/PLAU/MAPK1/KRAS/GSK3B/PIK3R3/CREB3L4/CDKN1B	3.97621674862171
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	96/1774	362/9376	1.4016082517892	SPP1/CSH2/CSH1/COL4A1/FN1/IGF2/COL4A2/CDKN1A/CCNE1/PIK3R1/MAPK3/YWHAG/LAMC1/FOXO3/ITGA6/CREB5/EFNA1/PPP2CB/ITGB1/MDM2/ITGA5/HSP90AB1/GNG12/IL2RB/YWHAZ/RXRA/MCL1/SOS1/CSF3R/ERBB3/BCL2L11/ITGB6/HSP90AA1/NFKB1/EREG/CREB3L2/ATF4/PDPK1/IFNAR1/OSMR/CSHL1/RBL2/FGFR3/LAMC2/DDIT4/PTK2/TSC1/PKN2/INSR/PIK3CA/PIK3AP1/ATF6B/RAF1/MAP2K1/LAMA5/SGK2/CSF1R/MET/FLT4/ITGA1/ERBB2/PPP2R3C/PPP2R5E/SYK/OSM/EFNA5/SGK3/RHEB/TSC2/CREB1/PRKAA1/PPP2CA/LPAR2/ATF2/MTOR/PIK3R2/PPP2R2D/GNG10/GNG4/MAPK1/KRAS/ITGAV/CDC37/GH2/GSK3B/IL2RG/JAK2/RPS6KB1/PIK3R3/COL9A3/ITGA3/CREB3L4/VEGFA/CDKN1B/PRLR/ITGA2	3.76440766746085
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	18/1774	41/9376	2.32034536805345	CDKN1A/CDKN2A/MAPK3/MDM2/MMP9/DAPK1/FGFR3/HBEGF/RAF1/MAP2K1/ERBB2/RB1/RASSF1/DAPK3/RPS6KA5/MAPK1/KRAS/VEGFA	4.09280286447774
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	48/1774	156/9376	1.6262249588067	NFKBIA/CDKN1A/CLDN19/PIK3R1/MAPK3/YWHAG/PPP2CB/YWHAZ/RXRA/LDLR/SOS1/CLDN23/STAT2/NFKB1/IFNAR1/TNF/OAS2/SCARB1/PIK3CA/CXCL10/RAF1/MAP2K1/FADD/CASP3/STAT1/CFLAR/EIF2AK2/RNASEL/TBK1/RB1/RIPK1/IKBKE/STAT3/PPARA/PPP2CA/MX2/PIK3R2/PPP2R2D/MAPK1/TRAF6/KRAS/GSK3B/TLR3/PIK3R3/MAVS/PIAS1/MX1/CLDN12	3.8100065721428
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	25/1774	66/9376	2.00198148337945	HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-DRB1/GATA3/HLA-DQB1/HLA-DQA1/TGFB2/IL1B/JUN/HLA-DMB/HLA-DMA/STAT6/NFKB1/HLA-DRB5/TNF/IFNGR1/HLA-DQA2/STAT4/STAT1/SMAD2/MAF/STAT3/IL12RB1/IL2RG	3.94598414968932
Human Diseases	Immune disease	hsa05330	Allograft rejection	17/1774	39/9376	2.30381869164282	HLA-B/HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-DRB1/HLA-A/HLA-DQB1/HLA-DQA1/HLA-DMB/HLA-DMA/CD40/HLA-DRB5/TNF/HLA-DQA2/CD86/HLA-F/HLA-E	3.94134398697221
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	69/1774	248/9376	1.47048768956613	TCF7L2/NFKBIA/FOS/RHOB/DYNLT1/MAPK3/IL1B/JUN/MAP2K3/TCF7/CYFIP2/HSP90AB1/DYNC1I2/LY96/RAB5A/HSP90AA1/SKP1/NFKB1/TNF/CYTH2/TNFSF10/DCTN4/RAB5B/PTPRC/DNM2/CD14/PIK3CA/ARF1/DCTN1/CYTH3/RAF1/MAP2K1/EXOC2/MAP3K7/MYO6/DCTN6/AHNAK/MAP2K7/FADD/CASP3/BIRC3/RIPK1/TCF7L1/RILP/MAP2K4/BIRC2/ROCK2/MLKL/DYNC1LI2/KLC4/NCKAP1L/GCC2/CYTH1/TNFRSF10A/PLEKHM2/PYCARD/MAPK1/DYNLL2/TRAF6/RAB9B/VPS11/TAB2/SNX33/CASP7/EXOC4/VPS41/AHNAK2/MAPK8/MYL10	3.62731108014165
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	36/1774	110/9376	1.72971200163985	FBN1/SKIL/BMPR2/MAPK3/TGFB2/PPP2CB/TGFBR1/NOG/BAMBI/FST/HAMP/EP300/ID4/SKP1/CREBBP/TNF/SMAD4/SMAD1/NCOR1/CDKN2B/SP1/RGMB/ACVR1/ZFYVE9/SMAD2/SMAD7/SKI/HDAC2/PPP2CA/LEMD3/ACVR2B/LTBP1/MAPK1/RPS6KB1/SIN3A/ACVR2A	3.71877752142329
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	61/1774	214/9376	1.50653784151134	HLA-B/NFKBIA/TAPBPL/FOS/HLA-A/TAPBP/PIK3R1/MAPK3/GNAQ/JUN/CXCR4/MAP2K3/ITPR2/GNG12/PPP3CA/SKP1/NFKB1/DDB1/TNF/PAK2/LIMK2/PTK2/ITPR3/PPP3R1/GNA11/PIK3CA/AP1G1/CUL5/RAF1/MAP2K1/TAP1/MAP3K7/CRKL/CD4/MAP2K7/FADD/CASP3/HLA-F/HLA-E/TBK1/CRK/RIPK1/RAC2/FBXW11/ATM/NFATC3/MTOR/PIK3R2/AP1S2/GNG10/GNG4/MAPK1/TRAF6/KRAS/PPP3CB/TAB2/RPS6KB1/PIK3R3/ATR/MAPK8/APOBEC3B	3.62094686318909
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	44/1774	144/9376	1.61493172992609	KLF4/SKIL/PIK3R1/BMPR2/JARID2/MAPK3/IL6ST/KAT6A/TCF7/ZFHX3/DUSP9/WNT7A/ID4/ISL1/AXIN2/BMI1/SMAD4/FGFR3/SMAD1/PIK3CA/FZD6/FZD1/RAF1/MAP2K1/ACVR1/RIF1/WNT6/FZD7/SMAD2/FZD8/STAT3/REST/HOXA1/WNT2B/PIK3R2/ACVR2B/MAPK1/KRAS/GSK3B/JAK2/ACVR2A/PIK3R3/DVL2/WNT5B	3.59218557277871
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	54/1774	187/9376	1.52621647203516	NFKBIA/CXCL2/CTSB/MAP1LC3B/CXCL3/MAPK3/IL1B/JUN/GABARAPL2/ITPR2/GABARAP/HSP90AB1/GBP3/ANTXR2/TNFAIP3/IFI16/XIAP/STAT2/HSP90AA1/NFKB1/GABARAPL1/IFNAR1/TNF/OAS2/GBP2/ITPR3/CCL2/PKN2/CCL5/CYBB/NEK7/MAP3K7/FADD/TRPM7/STAT1/BIRC3/RNASEL/TBK1/ANTXR1/RIPK1/IKBKE/BIRC2/GPSM3/PYCARD/MAPK1/TRAF6/CARD6/TAB2/GBP1/PLCB1/NAMPT/MCU/MAVS/MAPK8	3.51115198906486
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	23/1774	62/9376	1.96065025275485	FOXO1/HSPA1B/PIK3R1/FOXO3/PRKAG2/IRS2/HSPA8/SOD1/EIF4EBP2/HSPA6/CAT/INSR/PIK3CA/SIRT1/PRKAB2/HDAC2/PRKAA1/MTOR/PIK3R2/KRAS/RPS6KB1/PIK3R3/ADCY7	3.66599225087983
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	45/1774	150/9376	1.58556933483653	TCF7L2/CDKN1A/CCNE1/PIK3R1/MAPK3/TGFB2/GADD45A/TGFBR1/TCF7/WNT7A/RXRA/SOS1/RXRB/AXIN2/SMAD4/CDKN2B/PIK3CA/FZD6/FZD1/RAF1/MAP2K1/JUP/MET/GADD45B/ERBB2/WNT6/FZD7/SMAD2/RB1/TCF7L1/FZD8/FRAT1/GAB1/FRAT2/WNT2B/MTOR/PIK3R2/MAPK1/KRAS/GSK3B/RPS6KB1/PIK3R3/DVL2/WNT5B/CDKN1B	3.49233376737824
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	26/1774	75/9376	1.83221345358888	GSTT1/CDKN1A/CDKN2A/PIK3R1/MAPK3/MDM2/XIAP/PDPK1/MAP3K5/PMAIP1/PIK3CA/BBC3/FADD/CASP3/ERBB2/BIRC3/REV3L/TOP2B/BIRC2/GSTM4/ATM/PIK3R2/MAPK1/ATP7A/POLH/PIK3R3	3.49541749139276
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	36/1774	115/9376	1.65450713200333	FOS/CDKN1A/JUND/GATA3/MAPK3/WNK2/WNK1/GNAQ/CREB5/AKAP13/ITPR2/NR4A2/EGR1/RXRA/CREB3L2/ATF4/RXRB/MAFB/ITPR3/GNA11/HBEGF/ATF6B/SP1/RAF1/MAP2K1/PDE4C/GNA13/CREB1/PDE4A/ATF2/PLD1/MAPK1/PLCB1/CREB3L4/ADCY7/PTH1R	3.41140180337808
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	32/1774	99/9376	1.7083575324838	FOS/PIK3R1/MAPK3/JUN/DGKH/CHKB/RALGDS/SOS1/LYPLA1/PDPK1/GPCPD1/TSC1/SLC44A2/PIK3CA/SP1/HIF1A/RAF1/MAP2K1/SLC22A4/SLC44A5/RAC2/RHEB/TSC2/PLD1/MTOR/PIK3R2/MAPK1/KRAS/RPS6KB1/PIK3R3/SLC22A5/MAPK8	3.42266858545042
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	50/1774	174/9376	1.51874457359821	MAN1A1/HSPA1B/RRBP1/DNAJB1/OS9/DNAJA1/HSP90AB1/MBTPS1/PPP1R15A/HSPA8/EDEM3/SEC31A/HSP90AA1/SKP1/GANAB/ATF4/MAP3K5/SEL1L/HSPA6/CAPN2/UBE2G2/SEC63/ATF6B/DERL3/HERPUD1/AMFR/FBXO6/SEC24D/EIF2AK3/SEC24A/MAP2K7/UBQLN1/RPN2/UBE2D1/UGGT2/NFE2L2/DDIT3/UBQLN2/RNF5/SEC24C/UBE2D4/ATF6/DNAJB2/UBXN2A/DNAJC1/UBE2J1/FBXO2/MAPK8/XBP1/UBE4B	3.33645744302035
Human Diseases	Immune disease	hsa05310	Asthma	14/1774	32/9376	2.31228861330327	HLA-DRA/PRG2/HLA-DPA1/HLA-DPB1/HLA-DRB1/FCER1G/HLA-DQB1/HLA-DQA1/HLA-DMB/HLA-DMA/CD40/HLA-DRB5/TNF/HLA-DQA2	3.59200099314209
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	24/1774	69/9376	1.83834125778148	FCER1G/PIK3R1/MAPK3/VAV3/MAP2K3/SOS1/ALOX5AP/PDPK1/TNF/PIK3CA/RAF1/MAP2K1/MAP2K7/LCP2/SYK/MAP2K4/RAC2/VAV2/PIK3R2/ALOX5/MAPK1/KRAS/PIK3R3/MAPK8	3.37628455144145
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	41/1774	138/9376	1.57024982435502	PTPRF/FOXO1/PIK3R1/MAPK3/PRKAG2/IRS2/FBP1/SOS1/PPP1R3D/FASN/PRKAR1A/PDPK1/PHKA2/TSC1/PDE3B/SOCS1/INSR/PIK3CA/PHKB/FLOT2/RAF1/MAP2K1/SREBF1/PRKAR2A/CRKL/RAPGEF1/PRKAB2/CRK/PPP1CC/RHEB/TSC2/PRKAA1/MTOR/PIK3R2/MAPK1/KRAS/GSK3B/RPS6KB1/PIK3R3/INPPL1/MAPK8	3.25997476102283
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	41/1774	139/9376	1.55895306302872	KRT14/FOS/HSPA1B/PIK3R1/CTSD/MAPK3/GNAQ/CREB5/JUN/ITPR2/MMP9/HSP90AB1/NCOA1/KRT19/HSPA8/SOS1/KRT16/HSP90AA1/CREB3L2/ATF4/NCOA2/HSPA6/ITPR3/PIK3CA/HBEGF/ATF6B/SP1/RAF1/MAP2K1/RARA/CREB1/ATF2/PIK3R2/MAPK1/KRAS/PLCB1/PIK3R3/CREB3L4/KRT17/ADCY7/GABBR2	3.20712422338856
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	31/1774	98/9376	1.67185882244668	MARCKS/ASAP3/PIK3R1/MAPK3/VAV3/FCGR3A/LIMK2/PTPRC/DNM2/PRKCE/PIK3CA/ASAP1/RAF1/SCIN/MAP2K1/CRKL/FCGR2A/FCGR1A/SYK/CRK/MARCKSL1/GSN/RAC2/VAV2/HCK/PLD1/PIK3R2/MAPK1/RPS6KB1/PIK3R3/INPPL1	3.22970154676819
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	17/1774	44/9376	2.04202111304704	HLA-B/HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-DRB1/HLA-A/HLA-DQB1/HLA-DQA1/IL1B/HLA-DMB/HLA-DMA/HLA-DRB5/TNF/HLA-DQA2/CD86/HLA-F/HLA-E	3.34667858764736
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	21/1774	59/9376	1.88118395658571	TCF7L2/CDKN1A/PIK3R1/MAPK3/FOXO3/GADD45A/TCF7/SOS1/PDPK1/AXIN2/PIK3CA/RAF1/MAP2K1/GADD45B/ERBB2/TCF7L1/PIK3R2/MAPK1/KRAS/GSK3B/PIK3R3	3.2798429815176
Human Diseases	Infectious disease: viral	hsa05162	Measles	40/1774	136/9376	1.55447974003581	NFKBIA/FOS/CD46/HSPA1B/CCNE1/PIK3R1/IL1B/JUN/IL2RB/HSPA8/TNFAIP3/STAT2/NFKB1/IFNAR1/OAS2/HSPA6/PIK3CA/CSNK2A2/MAP3K7/BBC3/FADD/CASP3/STAT1/IFIH1/EIF2AK2/TBK1/IKBKE/STAT3/MX2/PIK3R2/TRAF6/RAB9B/TAB2/GSK3B/IL2RG/PIK3R3/MAVS/MAPK8/MX1/CDKN1B	3.14642702856815
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	32/1774	103/9376	1.64201355063977	COL4A1/FN1/COL4A2/CXCL2/CXCL3/PIK3R1/PRDX1/TGFB2/IL1B/LAMC1/SERPINB9/GNAQ/ITGB2/SERPINB6/HSPB1/RAB5A/NFKB1/NOS2/TNF/RAB5B/LAMC2/PTK2/CD14/GNAL/GNA11/PIK3CA/LAMA5/CASP3/ITGAM/PIK3R2/PLCB1/PIK3R3	3.16483585659126
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	31/1774	99/9376	1.65497135959368	FOS/CDKN1A/CDKN2A/PIK3R1/MAPK3/JUN/NOTCH2/MDM2/MMP9/SOS1/JAG2/PTK2/NCOR1/PIK3CA/HBEGF/SP1/RAF1/MAP2K1/ERBB2/RB1/MED1/CARM1/MTOR/PIK3R2/MAPK1/KRAS/RPS6KB1/PIK3R3/ADCY7/MAPK8/CDKN1B	3.16471526601901
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	25/1774	75/9376	1.76174370537392	SERPINE1/IGFBP3/CDKN1A/CDKN2A/CCNE1/GADD45A/MDM2/CCNG2/SESN1/PMAIP1/RRM2B/GORAB/BBC3/GADD45B/CASP3/ZMAT3/SESN3/SIAH1/ATM/MDM4/CCNG1/TSC2/TNFRSF10A/SESN2/ATR	3.19943430407182
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	51/1774	184/9376	1.46492818979462	PIK3R1/BMPR2/MAPK3/PARD6G/EFNB2/EFNA1/CXCR4/ITGB1/PLXNB2/PPP3CA/CAMK2G/SSH2/SEMA4C/RASA1/NTN4/PDPK1/DPYSL2/PAK2/LIMK2/SEMA3C/PTK2/NRP1/PPP3R1/EPHB3/PIK3CA/EFNB1/RAF1/SRGAP2/SEMA4B/MET/EPHB2/RYK/SEMA5B/NCK1/EFNA5/RAC2/ROCK2/PLXNC1/PTCH1/NFATC3/PIK3R2/MAPK1/KRAS/PPP3CB/GSK3B/PTPN11/ARHGEF12/PIK3R3/WNT5B/CAMK2D/SEMA4G	3.07672227916041
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	17/1774	45/9376	1.99664286609044	HLA-B/HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-DRB1/HLA-A/HLA-DQB1/HLA-DQA1/IL1B/HLA-DMB/HLA-DMA/HLA-DRB5/TNF/HLA-DQA2/CD86/HLA-F/HLA-E	3.23727980437573
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	41/1774	142/9376	1.52601743493656	FOS/GSTT1/PIK3R1/BMPR2/DUSP1/IL1B/HMOX1/JUN/MMP9/HSP90AB1/CTSL/ICAM1/NCF2/HSP90AA1/NFKB1/SQSTM1/TNF/MAP3K5/PTK2/CCL2/PIK3CA/ARHGEF2/ACVR1/MAP3K7/MAP2K7/KLF2/MAP2K4/NFE2L2/RAC2/GSTM4/PRKAA1/SDC2/PIK3R2/ACVR2B/ITGAV/SDC4/ACVR2A/PIK3R3/VEGFA/MAPK8/MAP2K5	3.05103991675523
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	10/1774	21/9376	2.51677672196274	DSE/XYLT1/CHST14/CHPF2/B4GALT7/B3GALT6/B3GAT3/CHST11/CSGALNACT1/CHST12	3.3613049857259
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	45/1774	160/9376	1.48647125140924	HLA-B/HLA-DRA/PTPRF/HLA-DPA1/HLA-DPB1/HLA-DRB1/HLA-A/CLDN19/HLA-DQB1/HLA-DQA1/ITGA6/ESAM/ITGB2/ITGB1/MAG/JAM2/HLA-DMB/HLA-DMA/ICAM1/CLDN23/GLG1/CD40/NLGN4X/PTPRS/HLA-DRB5/PDCD1LG2/HLA-DQA2/PTPRC/CD22/CD99L2/CD99/CD274/CD4/ALCAM/ITGAM/CD86/HLA-F/HLA-E/PVR/ITGAL/CD276/SDC2/ITGAV/SDC4/CLDN12	2.9980885225395
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	32/1774	105/9376	1.61073710205616	MAP1LC3B/FOXO3/JUN/GABARAPL2/UBB/FIS1/GABARAP/RAB5A/ATF4/GABARAPL1/SQSTM1/CCZ1B/MON1B/RAB5B/MUL1/CSNK2A2/SP1/AMFR/HIF1A/EIF2AK3/UBC/HUWE1/USP8/TBK1/SIAH1/OPTN/RRAS2/NBR1/KRAS/ARIH1/MAPK8/TBC1D15	3.04007414852313
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	44/1774	157/9376	1.48121126821247	TCF7L2/SERPINE1/WWTR1/BMPR2/YWHAG/TGFB2/PARD6G/PPP2CB/TEAD1/ITGB2/TGFBR1/TCF7/YWHAZ/WNT7A/LATS1/AXIN2/SMAD4/TEAD3/SMAD1/RASSF6/FZD6/FZD1/STK3/BBC3/WNT6/BIRC3/FZD7/SMAD2/TCF7L1/DLG1/RASSF1/BIRC2/FBXW11/PPP1CC/FZD8/SMAD7/PPP2CA/WNT2B/PPP2R2D/WTIP/GSK3B/TEAD2/DVL2/WNT5B	2.93725884593349
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	25/1774	78/9376	1.69398433209031	FOS/MAPK3/C1QB/C1QA/IL1B/JUN/ITGB2/ITGB1/IRF1/ITGA5/SERPING1/LY96/NFKB1/NOS2/C1QC/TNF/C2/CD14/CASP3/ITGAM/PYCARD/MAPK1/TRAF6/CASP7/MAPK8	2.97303970561399
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	54/1774	203/9376	1.40592354813091	SPP1/COL4A1/FN1/COL4A2/PIK3R1/MAPK3/VAV3/LAMC1/ITGA6/JUN/ITGB1/TLN2/ITGA5/SOS1/ITGB6/XIAP/RASGRF1/PDPK1/PAK2/LAMC2/PTK2/EMP2/CAPN2/PIK3CA/PARVG/RAF1/FLNB/MAP2K1/LAMA5/CRKL/MET/FLT4/ITGA1/ERBB2/BIRC3/RAPGEF1/CRK/BIRC2/RAC2/VAV2/ROCK2/PPP1CC/PPP1R12B/PIK3R2/MAPK1/ITGAV/GSK3B/PIK3R3/COL9A3/ITGA3/VEGFA/MAPK8/ITGA2/MYL10	2.82445774255936
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	38/1774	133/9376	1.51006603317765	HLA-B/TYROBP/HLA-A/FCER1G/PIK3R1/MAPK3/VAV3/ITGB2/FCGR3A/PPP3CA/SOS1/HCST/ICAM1/IFNAR1/TNF/TNFSF10/IFNGR1/CD48/PPP3R1/PIK3CA/RAF1/MAP2K1/LCP2/CASP3/HLA-E/SYK/RAC2/VAV2/ITGAL/TNFRSF10A/PIK3R2/MAPK1/KRAS/PPP3CB/LAT2/PTPN11/PIK3R3/PTPN6	2.86183282572455
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	65/1774	253/9376	1.35786570177041	NFKBIA/FOXO1/MAP1LC3B/PIK3R1/MAPK3/IL1B/FOXO3/JUN/ITGB1/UBB/ITPR2/TLN2/PLCD3/MDM2/ITGA5/HCLS1/SKP1/NFKB1/SQSTM1/TNF/CYTH2/CD44/TECPR1/RRAGC/PTK2/CD14/ITPR3/CAPN2/CCL5/PRKCE/PIK3CA/ARHGEF2/ARF1/FNBP1/CYTH3/MAP3K7/CRKL/UBC/FNBP1L/UBE2D1/TBK1/CRK/RIPK1/FBXW11/ROCK2/ATM/UBE2D4/CYTH1/WIPI1/TNIP1/RPS6KA5/BCL10/MTOR/PIK3R2/PYCARD/MAPK1/TRAF6/ATG14/TAB2/GSK3B/PLCB1/RPS6KB1/PIK3R3/MAPK8/MYL10	2.78746879077466
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	26/1774	83/9376	1.65561456649597	PIPOX/PRDX1/FAR2/IDH1/ACSL5/ACOX1/ABCD1/NUDT19/AGXT/SOD1/NOS2/PEX11B/EPHX2/CAT/MLYCD/CRAT/SCP2/PEX19/DECR2/FAR1/GSTK1/ABCD4/PEX7/AMACR/ACAA1/ACOX3	2.89806542167877
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	9/1774	19/9376	2.50353052868925	HGSNAT/NAGLU/HEXA/GALNS/GUSB/IDS/GNS/GLB1/SGSH	3.16897818669847
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	21/1774	63/9376	1.76174370537392	PIPOX/PRDM2/KMT2C/ASH1L/PRDM16/PLOD3/SMYD3/AADAT/ALDH9A1/SETD2/SETD1B/PLOD2/NSD1/KMT2B/EHMT1/EHMT2/KMT2D/TMLHE/PLOD1/KMT2E/DOT1L	2.93044018193861
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	36/1774	125/9376	1.52214656144307	FCER1G/PIK3R1/CTSD/MAPK3/GNAQ/PPP2CB/CERS6/ASAH1/NFKB1/PDPK1/TNF/MAP3K5/CERS2/PRKCE/PIK3CA/RAF1/MAP2K1/GNA13/PPP2R3C/PPP2R5E/RAC2/ROCK2/SPTSSA/NSMAF/PPP2CA/PLD1/SPTLC2/PIK3R2/PPP2R2D/MAPK1/KRAS/SMPD1/PLCB1/PIK3R3/MAPK8/DEGS2	2.83890985010604
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	23/1774	71/9376	1.71211712212395	FOS/PIK3R1/MAPK3/FOXO3/IRF1/SOS1/TH/NFKB1/SOCS1/PIK3CA/RAF1/MAP2K1/STAT1/CISH/STAT3/PIK3R2/MAPK1/KRAS/GSK3B/JAK2/PIK3R3/MAPK8/PRLR	2.90951718709017
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	30/1774	100/9376	1.58556933483653	HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-DRB1/CSF2RA/CD59/HLA-DQB1/HLA-DQA1/IL1B/ITGA6/HLA-DMB/ITGA5/HLA-DMA/CD36/CSF3R/CD37/HLA-DRB5/TNF/CD44/MME/HLA-DQA2/CD14/CD22/CSF1R/CD4/FCGR1A/ITGAM/ITGA1/ITGA3/ITGA2	2.84378309884841
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	16/1774	44/9376	1.92190222404428	ARHGDIB/CREB5/VAMP2/DYNC1I2/RAB5A/CREB3L2/STX4/DCTN4/RAB5B/DCTN1/DCTN6/DYNC1LI2/CREB1/RAB11B/DYNLL2/CREB3L4	2.96089051793921
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	53/1774	200/9376	1.40058624577227	NFKBIA/FOS/CLDN19/MAPK3/IL1B/TJP1/JUN/ITGB1/CYFIP2/CLDN23/HCLS1/NFKB1/TNF/PAK2/CYTH2/WIPF2/TNFSF10/RAB1A/MYO1D/ARHGEF2/ARF1/CYTH3/SEC24D/MAP3K7/MYO1F/MYO6/SEC24A/FCGR2A/FADD/GNA13/CASP3/BAIAP2/NCK1/RIPK1/ROCK2/NCKAP1L/SEC24C/CYTH1/LPAR2/TNFRSF10A/PYCARD/MAPK1/TRAF6/BAIAP2L1/TAB2/PTPN11/CASP7/ARHGEF12/MYO5B/MAPK8/PTPN6/CLDN12/MYO5C	2.76619532051287
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	13/1774	33/9376	2.08206074271463	VAMP2/SNAP23/VAMP7/STX11/STX7/STX4/GOSR1/STX16/SNAP29/STX17/BET1/STX3/STX5	3.00790385222987
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	41/1774	148/9376	1.46415186324995	TCF7L2/FOS/CDKN1A/PIK3R1/MAPK3/GADD45A/JUN/NOTCH2/TCF7/WNT7A/NCOA1/SOS1/JAG2/AXIN2/PIK3CA/FZD6/SP1/FZD1/RAF1/MAP2K1/FLT4/GADD45B/ERBB2/WNT6/FZD7/RB1/TCF7L1/FZD8/FRAT1/FRAT2/WNT2B/MTOR/PIK3R2/MAPK1/NFKB2/KRAS/GSK3B/RPS6KB1/PIK3R3/DVL2/WNT5B	2.74938574286496
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	12/1774	30/9376	2.1140924464487	PIGT/PGAP3/PIGP/B3GALT4/PIGM/PIGN/MPPE1/PIGV/PIGC/PIGU/PIGQ/PIGG	2.95234755541591
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	51/1774	193/9376	1.39661547628088	NFKBIA/CCL3/CXCL2/CCR1/CXCL3/PIK3R1/MAPK3/VAV3/GRK4/FOXO3/CCL4/GNAQ/CXCR6/CXCR4/GNG12/TIAM1/CCL20/SOS1/STAT2/NFKB1/CXCL16/CCL18/PREX1/PTK2/CCL2/CCL5/PIK3CA/CXCL9/CXCL10/RAF1/MAP2K1/CRKL/STAT1/FGR/CRK/RAC2/VAV2/ROCK2/HCK/STAT3/PIK3R2/GNG10/GNG4/MAPK1/KRAS/GSK3B/PLCB1/XCR1/JAK2/PIK3R3/ADCY7	2.68939462403532
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	23/1774	73/9376	1.6652098037096	CDKN1A/CDKN2A/PIK3R1/MAPK3/FOXO3/GADD45A/RXRA/SOS1/PDPK1/RXRB/PIK3CA/RAF1/MAP2K1/MET/GADD45B/ERBB2/RB1/RASSF1/STAT3/PIK3R2/MAPK1/KRAS/PIK3R3	2.75617680812565
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	29/1774	99/9376	1.54819901381344	HLA-DRA/HLA-DPA1/KRT14/HLA-DPB1/HLA-DRB1/HLA-DQB1/C1QB/HLA-DQA1/C1QA/ITGB2/FCGR3A/HLA-DMB/HLA-DMA/KRT19/KRT16/ICAM1/C1QC/HLA-DRB5/HLA-DQA2/FPR3/C2/C5AR1/FCGR2A/FPR1/FCGR1A/ITGAM/C3AR1/ITGAL/KRT17	2.64880862715621
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	59/1774	232/9376	1.34408894763441	FN1/PIK3R1/MAPK3/VAV3/DIAPH2/ITGA6/ITGB2/CXCR4/ITGB1/RGCC/ITGA5/CYFIP2/ARHGEF7/GNG12/SSH2/TIAM1/SOS1/ITGB6/PAK2/LIMK2/CHRM5/FGFR3/PTK2/PIP4K2A/ITGAX/SLC9A1/PIK3CA/RAF1/SCIN/MAP2K1/CRKL/FGD3/GNA13/ITGAM/ITGA1/BAIAP2/PIKFYVE/CRK/GSN/RAC2/VAV2/ROCK2/PIP4K2C/PPP1CC/ITGAL/RRAS2/NCKAP1L/PPP1R12B/LPAR2/PIK3R2/GIT1/MAPK1/KRAS/ITGAV/ARHGEF12/PIK3R3/ITGA3/ITGA2/MYL10	2.56356964254175
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	36/1774	130/9376	1.46360246292603	COL4A1/COL4A2/NFKBIA/FOS/PIK3R1/MAPK3/CREB5/JUN/TGFBR1/MMP9/GNG12/SOS1/NFKB1/CREB3L2/NOS2/ATF4/PIK3CA/ATF6B/RAF1/MAP2K1/MAP2K7/SMAD2/MAP2K4/CREB1/ATF2/PIK3R2/GNG10/GNG4/MAPK1/KRAS/PLCB1/PIK3R3/CREB3L4/VEGFA/ADCY7/MAPK8	2.57121847185378
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	29/1774	101/9376	1.51754160759932	TCF7L2/MAPK3/GNAQ/TCF7/CAMK2G/WNT7A/EP300/CREB3L2/CREBBP/FZD6/FZD1/RAF1/MAP2K1/WNT6/FZD7/TCF7L1/FZD8/CREB1/WNT2B/MAPK1/KRAS/GSK3B/PLCB1/DVL2/CREB3L4/WNT5B/CAMK2D/MC1R/ADCY7	2.52608239167721
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	12/1774	32/9376	1.98196166854566	BCL2L11/XIAP/PMAIP1/BIRC6/BBC3/FADD/CASP3/BIRC3/BIRC2/CASP7/MAPK8/BIRC7	2.6878289218443
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	24/1774	80/9376	1.58556933483653	PIK3R1/MAPK3/FOXO3/SOS1/ERBB3/BCL2L11/FGFR3/PIK3CA/RAF1/MAP2K1/MET/ERBB2/NF1/STAT3/GAB1/MTOR/PIK3R2/MAPK1/KRAS/GSK3B/JAK2/RPS6KB1/PIK3R3/VEGFA	2.540819271327
NA	NA	hsa04518	Integrin signaling	41/1774	154/9376	1.40710698546099	SPP1/FBN1/COL4A1/FN1/COL4A2/LIMS2/PIK3R1/LAMC1/ITGA6/ITGB2/ITGB1/TLN2/ITGA5/FERMT1/ICAM1/ITGB6/LAMC2/PTK2/LIMS1/ITGAX/PIK3CA/PARVG/FLNB/LAMA5/MET/FLT4/ITGAM/ITGA1/ERBB2/RAC2/ITGAL/FERMT3/MTOR/PIK3R2/ITGAV/GSK3B/PIK3R3/COL9A3/ITGA3/VEGFA/ITGA2	2.46067846908988
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	44/1774	168/9376	1.38422719707951	IL1B/GLUL/HSP90AB1/CAMK2G/FTL/VPS4B/STAT6/TNFAIP3/XIAP/STAT2/HSP90AA1/CHMP3/CHMP4C/SQSTM1/IFNAR1/TNF/TNFSF10/IFNGR1/CYLD/CHMP1A/CAPN2/CYBB/VPS4A/STAT4/FADD/TRPM7/STAT1/BIRC3/CFLAR/EIF2AK2/RIPK1/BIRC2/MLKL/STAT3/TNFRSF10A/PYCARD/SMPD1/SPATA2L/TLR3/JAK2/CAMK2D/CHMP7/MAPK8/CHMP6	2.42749643910891
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	44/1774	168/9376	1.38422719707951	CSH2/CSH1/CSF2RA/CDKN1A/CSF2RB/PIM1/PIK3R1/IL6ST/IL10RB/IL2RB/MCL1/STAT6/SOS1/CSF3R/EP300/STAT2/CREBBP/IFNAR1/OSMR/IL10RA/CSHL1/IFNGR1/IL13RA1/SOCS1/PIK3CA/STAT4/RAF1/IL20RA/STAT1/CISH/OSM/IL27/STAT3/MTOR/PIK3R2/IL12RB1/GH2/IL2RG/PTPN11/JAK2/PIK3R3/PIAS1/PTPN6/PRLR	2.42749643910891
NA	NA	hsa03272	Virion - Hepatitis viruses	16/1774	48/9376	1.76174370537392	CLDN19/HSPG2/LAMP2/DPP4/VPS4B/LDLR/IST1/CLDN23/SCARB1/CHMP1A/VPS4A/PDCD6IP/TSG101/TGOLN2/CHMP7/CLDN12	2.55584043951686
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	28/1774	98/9376	1.51006603317765	PIK3R1/IP6K2/DGKH/ITPR2/PLCD3/ITPR3/PIP4K2A/IPMK/PIK3CA/INPP5B/PIKFYVE/PI4KA/PIP4K2C/CDIPT/PI4KB/PIK3R2/OCRL/ITPKC/PI4K2A/IPPK/PLCB1/PIK3R3/INPPL1/MTMR6/CDS1/SYNJ2/PPIP5K2/IP6K1	2.45194526181651
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	11/1774	29/9376	2.00474283714963	WWTR1/TEAD1/LATS1/TEAD3/RASSF2/RASSF4/RASSF6/STK3/RASSF1/WTIP/TEAD2	2.61767852234373
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	22/1774	73/9376	1.59280937746135	CXCR4/VPS4B/ELL2/EP300/CREBBP/SERINC3/CCNT1/VPS4A/NUP153/PDCD6IP/TSG101/CD4/SUPT5H/ELL/HGS/CCNT2/AFF4/MX2/MDFIC/MX1/APOBEC3B/CHMP6	2.4561987040583
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	21/1774	69/9376	1.6085486005588	FOS/FOSB/CREB5/JUN/PPP3CA/CAMK2G/TH/CREB3L2/ATF4/PPP3R1/ATF6B/SIRT1/PPP1CC/GRIN3B/CREB1/DRD1/HDAC2/ATF2/PPP3CB/CREB3L4/CAMK2D	2.45083159130828
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	13/1774	37/9376	1.85697309485359	TCF7L2/CDKN1A/MAPK3/GADD45A/TCF7/RXRA/RXRB/MAP2K1/GADD45B/TCF7L1/NCOA4/MAPK1/KRAS	2.52299491298297
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	23/1774	78/9376	1.55846558552308	IP6K2/PLCD3/PIP4K2A/PLCH1/IPMK/PIK3CA/INPP5B/PIKFYVE/PI4KA/PIP4K2C/CDIPT/PI4KB/OCRL/ITPKC/PI4K2A/IPPK/PLCB1/INPPL1/MTMR6/SYNJ2/PPIP5K2/IP6K1/FIG4	2.39247528107455
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	32/1774	117/9376	1.44553329671706	MORF4L2/SMARCA1/BRD7/MBD3/BAZ2B/MORF4L1/SMARCE1/EPC1/CHD4/ARID1A/RBBP4/SMARCD2/GATAD2B/PBRM1/ING3/SMARCD1/EPC2/INO80D/PHF6/BRD8/CDK2AP2/RSF1/ARID1B/BPTF/CHD3/KAT5/HDAC2/DPF1/RBBP7/INO80/POLE3/ARID2	2.34255377121797
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	38/1774	144/9376	1.39471376675435	VLDLR/PIK3R1/PPIF/GNAQ/ITPR2/ATXN1/PUM1/MAP3K5/BEAN1/ITPR3/PIK3CA/ATXN2/SP1/PUM2/ATXN2L/TBP/GTF2B/ATXN1L/AFG3L2/PSMA6/GRIN3B/KAT5/WIPI1/MTOR/RBPJ/PIK3R2/ATP2A2/ULK2/ATG14/PLCB1/RB1CC1/ATG2B/ATG13/PIK3R3/MCU/MAPK8/XBP1/NFYA	2.30576018330122
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	23/1774	79/9376	1.53873817304811	SLC17A8/CLTB/SLC6A2/VAMP2/ATP6V1G1/ATP6V0D1/ATP6V0E1/SLC6A4/ATP6V1H/DNM2/AP2A2/ATP6V1A/ATP6V1D/NAPA/ATP6V0A1/AP2B1/SYT1/CPLX1/ATP6V1E1/ATP6V1B2/STX3/SLC1A3/STXBP1	2.32283516788849
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	19/1774	63/9376	1.5939585905764	TCF7L2/CDKN1A/GADD45A/TCF7/WNT7A/AXIN2/FZD6/FZD1/GADD45B/WNT6/FZD7/TCF7L1/GLI3/FZD8/PTCH1/WNT2B/GSK3B/DVL2/WNT5B	2.28496816967896
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	26/1774	93/9376	1.47759149482974	MAPK3/GNAQ/JUN/MAP2K3/ITPR2/CAMK2G/EGR1/MAP3K2/SOS1/ATF4/ITPR3/GNA11/HBEGF/RAF1/MAP2K1/MAP2K7/MAP3K1/MAP2K4/MAP3K3/PLD1/MAPK1/KRAS/PLCB1/CAMK2D/ADCY7/MAPK8	2.23590010547805
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	22/1774	76/9376	1.52993532308788	FABP7/ACSL5/ACOX1/OLR1/RXRA/CD36/PLIN2/CYP27A1/PDPK1/RXRB/FABP4/LPL/SLC27A1/HMGCS1/SCP2/UBC/PPARD/CPT2/PPARA/ACAA1/PLIN5/ACOX3	2.24071542460803
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	17/1774	55/9376	1.63361689043763	PSAP/B4GALT5/CERS6/ASAH1/HEXA/UGCG/CERS2/GLB1/GBA2/GM2A/KDSR/SPTLC2/ARSA/SMPD1/CERK/NEU1/DEGS2	2.27654033748529
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	29/1774	107/9376	1.43244581651898	FOXO1/PRKAG2/GNAQ/CREB5/ITPR2/PPP3CA/CAMK2G/FBP1/EP300/CREB3L2/ATF4/CREBBP/PHKA2/SIK1/ITPR3/PDE3B/PPP3R1/PHKB/SIRT1/PRKAB2/CREB1/PPARA/PRKAA1/SIK2/ATF2/PPP3CB/PLCB1/CREB3L4/CAMK2D	2.17322984800737
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	9/1774	24/9376	1.98196166854566	EXTL3/XYLT1/NDST1/EXT2/GLCE/B4GALT7/B3GALT6/B3GAT3/HS2ST1	2.32673230777841
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	16/1774	52/9376	1.6262249588067	APOE/MYLIP/ABCA1/LRP1/SOAT1/LDLR/CD36/CYP27A1/LPL/LIPG/SCARB1/LCAT/STARD3NL/LIPA/NPC1/NCEH1	2.18740613359509
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	19/1774	65/9376	1.54491371086636	GNAQ/CREB5/ITPR2/LDLR/CREB3L2/ATF4/SCARB1/ITPR3/GNA11/ATF6B/SP1/CREB1/ATF2/PDE8A/CACNA1G/PLCB1/CREB3L4/ADCY7/NCEH1	2.12953490952486
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	88/1774	388/9376	1.1987122119039	APOE/SLC39A8/PIK3R1/MAPK3/SLC39A11/PPIF/IL1B/BACE2/NDUFA13/GNAQ/IRS2/LRP1/ITPR2/NCSTN/ADAM10/MT-ND3/PPP3CA/WNT7A/MT-ND4L/ADAM17/NFKB1/NOS2/ATF4/SLC39A13/LPL/TNF/MAP3K5/AXIN2/MME/CHRM5/ITPR3/CAPN2/CYBB/INSR/PPP3R1/PIK3CA/FZD6/CSNK2A2/FZD1/RAF1/MAP2K1/SLC39A7/EIF2AK3/PSEN1/MT-ND2/MAP2K7/FADD/CASP3/WNT6/SLC39A9/FZD7/EIF2AK2/FZD8/DDIT3/PTGS2/FRAT1/PSMA6/KLC4/FRAT2/WIPI1/WNT2B/COX7A2/SDHD/MTOR/PIK3R2/ATP2A2/ULK2/MAPK1/ATF6/BACE1/ATG14/KRAS/PPP3CB/GSK3B/NOX4/PLCB1/CASP7/RB1CC1/ATG2B/ATG13/PIK3R3/MCU/DVL2/WNT5B/MT-ATP8/UQCR10/MAPK8/XBP1	1.93111172989254
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	16/1774	54/9376	1.56599440477682	HLA-B/HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-DRB1/HLA-A/HLA-DQB1/HLA-DQA1/HLA-DMB/HLA-DMA/CD40/HLA-DRB5/HLA-DQA2/CD86/HLA-F/HLA-E	2.01489761060916
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	19/1774	67/9376	1.49879688367632	MAPK3/GNAQ/ITPR2/PPP3CA/CAMK2G/EP300/ATF4/CREBBP/ITPR3/PPP3R1/RAF1/MAP2K1/RPS6KA3/PPP1CC/MAPK1/KRAS/PPP3CB/PLCB1/CAMK2D	1.97928407765384
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	13/1774	42/9376	1.63590486927578	SLC39A8/MAP1LC3B/HMOX1/ACSL5/GPX4/FTL/SAT1/PRNP/LPCAT3/CYBB/NCOA4/GCLC/GSS	1.99517691284143
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	39/1774	158/9376	1.304582364106	CDKN1A/CDKN2A/CCNE1/YWHAG/TGFB2/GADD45A/PPP2CB/MDM2/ANAPC13/YWHAZ/ANAPC16/EP300/SKP1/CREBBP/RBL2/SMAD4/CDKN2B/CDC23/MAD2L2/NIPBL/ESCO1/GADD45B/PPP2R5E/ATRX/STAG1/MCM3/SMAD2/RB1/ATM/MAU2/HDAC2/PPP2CA/MCM4/PDS5A/TFDP2/STAG2/GSK3B/ATR/CDKN1B	1.86514868395758
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	56/1774	238/9376	1.24358379202865	RPS4Y1/NFKBIA/FOS/RPS10/PIK3R1/MAPK3/C1QB/C1QA/IL1B/IL6ST/RPS12/JUN/RPS27L/RPL10A/RPL26/RPL27A/RPL36A/RPS8/ADAM17/RPL17/STAT2/NFKB1/RPS21/C1QC/IFNAR1/TNF/OAS2/RPS29/C2/CCL2/CYBB/NRP1/PIK3CA/C5AR1/HBEGF/CXCL10/MAP3K7/FCGR2A/C3AR1/STAT1/IFIH1/SYK/EIF2AK2/TBK1/IKBKE/STAT3/MX2/PIK3R2/MAPK1/TRAF6/TAB2/TLR3/PIK3R3/MAVS/MAPK8/MX1	1.83869545313921
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	12/1774	38/9376	1.6690203524595	PIK3R1/MAPK3/PDPK1/INSR/PIK3CA/ATP1B1/NR3C2/PIK3R2/NEDD4L/MAPK1/KRAS/PIK3R3	1.99619381937859
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	14/1774	47/9376	1.57432416224903	PIK3R1/MAPK3/IRS2/TNF/SOCS1/PRKCE/INSR/PIK3CA/MTOR/PIK3R2/MAPK1/CACNA1G/PIK3R3/MAPK8	1.90672027002616
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	17/1774	60/9376	1.49748214956783	PIK3R1/MAPK3/HSPB1/PPP3CA/PTK2/PPP3R1/PIK3CA/RAF1/MAP2K1/RAC2/PTGS2/PIK3R2/MAPK1/KRAS/PPP3CB/PIK3R3/VEGFA	1.86739804918025
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	26/1774	100/9376	1.37416009019166	CCL3/CXCL2/CCR1/CXCL3/ACKR3/IL6ST/CCL4/CXCR4/IL10RB/IL2RB/CCL20/TNFRSF14/TNF/IL10RA/TNFSF10/CCL18/CCL2/CCL5/CXCL9/CXCL10/CSF1R/TNFRSF10D/IL20RA/TNFRSF10A/XCR1/IL2RG	1.8170865129877
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	18/1774	65/9376	1.46360246292603	SPP1/KISS1/PIK3R1/MAPK3/GNAQ/ITPR2/ITPR3/GNA11/PIK3CA/RAF1/MAP2K1/PIK3R2/MAPK1/KRAS/CACNA1G/PLCB1/PIK3R3/GABBR2	1.81176874293185
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	28/1774	110/9376	1.34533155683099	EPAS1/SERPINE1/CDKN1A/PIK3R1/MAPK3/HMOX1/CAMK2G/EP300/NFKB1/NOS2/CREBBP/IFNGR1/CYBB/INSR/PIK3CA/VHL/HIF1A/MAP2K1/ERBB2/STAT3/MTOR/PIK3R2/MAPK1/RPS6KB1/PIK3R3/CAMK2D/VEGFA/CDKN1B	1.75988777503352
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	19/1774	70/9376	1.43456273151876	NFKBIA/PRKAG2/IRS2/ACSL5/RXRA/CD36/NFKB1/RXRB/TNF/PRKAB2/NFKBIE/STAT3/PPARA/PRKAA1/MTOR/PTPN11/JAK2/MAPK8/CAMKK2	1.76286269431413
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	24/1774	93/9376	1.36393061061207	PTPRF/TCF7L2/MAPK3/TJP1/TGFBR1/TCF7/EP300/CREBBP/SMAD4/INSR/CSNK2A2/MAP3K7/MET/ERBB2/BAIAP2/TCF7L1/RAC2/ROCK2/KRIT1/MAPK1/SNAI1/NLK/PTPN6/MYL10	1.70378346235898
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	10/1774	32/9376	1.65163472378805	PPP2CB/GABARAPL2/GABARAP/GABARAPL1/WIPI1/PPP2CA/MTOR/ULK2/ATG2B/ATG13	1.7836568505465
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	9/1774	28/9376	1.69882428732485	CA2/ATP6V1G1/ATP6V0D1/ATP6V0E1/ATP6V1A/ATP6V1D/ATP6V0A1/ATP6V1E1/ATP6V1B2	1.78890042567976
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	14/1774	50/9376	1.47986471251409	HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-DRB1/HLA-DQB1/HLA-DQA1/CXCR4/HLA-DMB/HLA-DMA/CD40/HLA-DRB5/HLA-DQA2/TNFSF13B/CD86	1.64344291936215
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	28/1774	115/9376	1.28683888044704	FOS/PIK3R1/MAPK3/GNAQ/CREB5/ITPR2/GNG12/CAMK2G/CREB3L2/ATF4/CHRM5/ITPR3/GNA11/PIK3CA/MAP2K1/CREB1/KCNQ1/PIK3R2/GNG10/GNG4/MAPK1/KRAS/PLCB1/JAK2/PIK3R3/CREB3L4/CAMK2D/ADCY7	1.49505272928178
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	14/1774	51/9376	1.45084775736676	TJP1/ATP6V1G1/ATP6V0D1/ATP6V0E1/TJP2/ATP6V1H/ATP6V1A/ARF1/ATP6V1D/ATP6V0A1/ATP6AP1/ATP6V1E1/KCNQ1/ATP6V1B2	1.55951334288591
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	21/1774	83/9376	1.33722714986213	NFKBIA/IL1B/CCL4/IFI16/POLR2K/NFKB1/ZCCHC3/CCL5/CXCL10/POLR3D/FADD/CASP3/TBK1/RIPK1/IKBKE/MLKL/PYCARD/CASP7/MAVS/POLR3K/POLR3A	1.49067209944722
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	10/1774	34/9376	1.55447974003581	PRKAG2/SKP1/PER2/CRY1/CLOCK/PRKAB2/FBXW11/FBXL3/CREB1/PRKAA1	1.5646014290624
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	28/1774	116/9376	1.27574544182249	CLDN19/PIK3R1/VAV3/ESAM/ITGB2/CXCR4/ITGB1/JAM2/MMP9/ICAM1/CLDN23/NCF2/PTK2/CD99L2/CYBB/PIK3CA/CD99/ITGAM/RAC2/VAV2/ROCK2/ITGAL/SIPA1/PIK3R2/PTPN11/PIK3R3/CLDN12/MYL10	1.44354509939432
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	24/1774	98/9376	1.29434231415227	GNAQ/CREB5/ITPR2/NR4A2/CAMK2G/LDLR/CREB3L2/ATF4/SCARB1/ITPR3/PRKCE/GNA11/ATF6B/ATP1B1/ATP2B3/PRKD2/CREB1/ATF2/DAGLB/CACNA1G/PLCB1/CREB3L4/CAMK2D/ADCY7	1.41493688188094
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	22/1774	89/9376	1.30646162420987	SPP1/COL4A1/FN1/COL4A2/DAG1/LAMC1/ITGA6/ITGB1/HSPG2/ITGA5/CD36/ITGB6/CD44/LAMC2/LAMA5/ITGA1/ITGAV/SDC4/COL9A3/ITGA3/AGRN/ITGA2	1.40323979599522
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	6/1774	18/9376	1.76174370537392	HEXA/MAN2B2/AGA/GLB1/GBA2/NEU1	1.56261547014203
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	6/1774	18/9376	1.76174370537392	PRDX1/LMBRD1/HCFC1/ZNF76/ABCD4/MTR	1.56261547014203
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	25/1774	104/9376	1.27048824906773	LPCAT1/PCYT2/DGKH/CHKB/MBOAT7/PLD3/LYPLA1/LPCAT3/GPCPD1/PLB1/ETNK1/AGPAT1/CEPT1/LPIN2/LPIN1/LCAT/PLA2G15/GDPD5/CDIPT/LYPLA2/PLD1/GPD2/AGPAT4/PGS1/CDS1	1.33991384346894
Human Diseases	Cancer: specific types	hsa05214	Glioma	19/1774	76/9376	1.32130777903044	CDKN1A/CDKN2A/PIK3R1/MAPK3/GADD45A/MDM2/CAMK2G/SOS1/PIK3CA/RAF1/MAP2K1/GADD45B/RB1/MTOR/PIK3R2/MAPK1/KRAS/PIK3R3/CAMK2D	1.35857955707675
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	9/1774	31/9376	1.53442193693858	GCSH/GLDC/GLUL/AGXT/CAT/HYI/ACO1/MCEE/SHMT1	1.43970656200247
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	31/1774	133/9376	1.23189597443439	FOS/GNAQ/CREB5/PPP2CB/ITPR2/GNG12/PPP3CA/CAMK2G/TH/CREB3L2/ATF4/ITPR3/GNAL/ATF6B/CLOCK/PPP2R3C/PPP2R5E/PPP1CC/CREB1/DRD1/PPP2CA/ATF2/PPP2R2D/GNG10/GNG4/PPP3CB/GSK3B/PLCB1/CREB3L4/CAMK2D/MAPK8	1.30110116851988
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	13/1774	49/9376	1.40220417366496	FOSB/CREB5/JUN/TH/NFKB1/CREB3L2/ATF4/ATF6B/GRIN3B/CREB1/DRD1/ATF2/CREB3L4	1.36355336006059
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	8/1774	27/9376	1.56599440477682	ACOX1/ELOVL4/ELOVL5/ELOVL1/SCP2/ACOT2/ACAA1/ACOX3	1.42268893382696
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	18/1774	72/9376	1.32130777903044	NFKBIA/NFKB1/TNF/CYLD/TRIM25/CXCL10/MAP3K7/FADD/MAP3K1/IFIH1/TBK1/RIPK1/IKBKE/TRAF6/ZNFX1/RNF125/MAVS/MAPK8	1.32205995540507
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	101/1774	480/9376	1.11210071401729	GPX3/MAP1LC3B/MAPK3/PPIF/IL1B/NDUFA13/GNAQ/MAP2K3/UBB/ITPR2/HIP1/MT-ND3/PPP3CA/CAMK2G/WNT7A/FUS/MT-ND4L/ATXN1/RAB5A/SOD1/NFKB1/NOS2/ATF4/PRNP/SQSTM1/TNF/MAP3K5/AXIN2/RAB1A/CHRM5/DCTN4/ITPR3/CAPN2/UBE2G2/CYBB/CAT/GPX8/UBA7/PPP3R1/ATXN2/FZD6/CSNK2A2/FZD1/ATXN2L/DCTN1/RAF1/MAP2K1/EIF2AK3/UBC/DCTN6/PSEN1/MT-ND2/MAP2K7/FADD/CASP3/WNT6/TARDBP/FZD7/ATXN1L/TBK1/SPG11/GPR37/FZD8/OPTN/DDIT3/PTGS2/FRAT1/PSMA6/KLC4/FRAT2/WIPI1/WNT2B/COX7A2/SDHD/MTOR/ATP2A2/ULK2/DNAH11/MAPK1/ATF6/ATG14/KRAS/PPP3CB/GSK3B/NOX4/PLCB1/UBE2J1/CASP7/RB1CC1/ATG2B/ATG13/MCU/DVL2/WNT5B/CAMK2D/MT-ATP8/UQCR10/MAPK8/XBP1/UBE2L6/FIG4	1.21795186198669
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	7/1774	23/9376	1.6085486005588	IDI1/PCYOX1/HMGCS1/HMGCR/ICMT/ZMPSTE24/FNTB	1.4115043866932
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	34/1774	149/9376	1.20602589226939	FCER1G/PIK3R1/MAPK3/DGKH/RALGDS/SOS1/CYTH2/AGPAT1/DNM2/TSC1/INSR/PIK3CA/ARF1/CYTH3/RAF1/MAP2K1/GNA13/SYK/RHEB/TSC2/GAB1/RRAS2/CYTH1/LPAR2/PLD1/MTOR/PIK3R2/MAPK1/KRAS/PLCB1/PTPN11/PIK3R3/AGPAT4/ADCY7	1.22456880216742
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	5/1774	15/9376	1.76174370537392	HEXA/ST8SIA1/ST3GAL5/B3GALT4/GLB1	1.42623764191801
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	32/1774	140/9376	1.20805282654212	SPP1/SERPINE1/MAP1LC3B/MAPK3/PRKAG2/GNAQ/TGFBR1/ITPR2/GNG12/EGR1/NOS2/SMAD4/ITPR3/PDE3B/PRKCE/SLC9A1/RAF1/MAP2K1/GNA13/SMAD2/PRKAB2/KLF2/RRAS2/PRKAA1/MTOR/GNG10/GNG4/MAPK1/KRAS/PLCB1/RPS6KB1/ADCY7	1.19810309315876
Organismal Systems	Nervous system	hsa04730	Long-term depression	15/1774	60/9376	1.32130777903044	MAPK3/GNAQ/PPP2CB/ITPR2/CRH/ITPR3/GNA11/RAF1/MAP2K1/GNA13/PRKG1/PPP2CA/MAPK1/KRAS/PLCB1	1.20609256084689
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	37/1774	166/9376	1.17803344154521	MAPK3/RGS2/PPIF/GNAQ/CREB5/IRS2/GTF2I/ITPR2/PPP3CA/CREB3L2/ATF4/ITPR3/PDE3B/PRKCE/INSR/PPP3R1/GNA11/ATF6B/ATP1B1/ATP2B3/RAF1/MAP2K1/GNA13/SRF/ROCK2/PPP1CC/PRKG1/CREB1/KCNMB4/NFATC3/ATF2/ATP2A2/MAPK1/PPP3CB/PLCB1/CREB3L4/ADCY7	1.11795501751928
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	9/1774	33/9376	1.44142666803321	IDH1/AGXT/BCAT1/AADAT/DBT/GPT/OGDH/ACO1/BCKDHB	1.22707434327857
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	35/1774	157/9376	1.1782362360781	FOS/PIK3R1/IL1B/NDUFA13/PRKAG2/IRS2/JUN/CEBPA/RXRA/BCL2L11/NFKB1/ATF4/TNF/MAP3K5/MLXIP/INSR/PIK3CA/SREBF1/EIF2AK3/CASP3/PRKAB2/DDIT3/PPARA/PRKAA1/COX7A2/SDHD/MAP3K11/PIK3R2/GSK3B/CASP7/PIK3R3/UQCR10/MAPK8/XBP1/ITCH	1.08793371159201
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	10/1774	38/9376	1.39085029371625	GNPDA1/UGP2/HEXA/UXS1/GNE/RENBP/PMM1/PMM2/GFPT1/MPI	1.16620210095315
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	17/1774	71/9376	1.26547787287422	PIK3R1/MAPK3/IDH1/SLC1A5/FGFR3/PIK3CA/HIF1A/RAF1/MAP2K1/MET/ERBB2/MTOR/PIK3R2/MAPK1/KRAS/SIRT6/PIK3R3	1.08467049860549
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	14/1774	57/9376	1.29812694080184	ACSL5/ACOX1/ELOVL4/FASN/ELOVL5/ACAA2/ELOVL1/SCP2/ACADVL/CPT2/MECR/PPT2/ACAA1/ACOX3	1.09056739401272
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	63/1774	298/9376	1.11734751783782	CSH2/CSH1/EBI3/GDF15/IL1RAP/CSF2RA/IL17RE/CSF2RB/CCL3/CXCL2/CCR1/CXCL3/BMPR2/ACKR3/TGFB2/IL1B/IL6ST/CCL4/CXCR6/CXCR4/TGFBR1/IL10RB/INHA/IL2RB/IL1RN/CCL20/CSF3R/CD40/CXCL16/IFNAR1/TNFRSF14/TNF/OSMR/IL10RA/CSHL1/TNFSF10/IFNGR1/CCL18/IL13RA1/CCL2/TNFRSF18/CCL5/CXCL9/TNFSF13B/CXCL10/ACVR1/CSF1R/CD4/TNFRSF10D/IL20RA/OSM/IL27/IL17B/RELL2/TNFRSF10A/ACVR2B/IL12RB1/GH2/XCR1/IL2RG/ACVR2A/EDA2R/PRLR	0.994455751518908
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	12/1774	48/9376	1.32130777903044	BCAT1/HIBADH/ACAA2/HMGCS1/DBT/ABAT/ALDH9A1/MCEE/IL4I1/BCKDHB/ACAA1/MCCC1	1.0780678716265
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	11/1774	44/9376	1.32130777903044	TAF5L/GTF2I/TAF7/TBP/GTF2B/TAF11/TAF13/TAF1/TAF3/GTF2E1/TAF4	1.03195016939849
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	12/1774	49/9376	1.29434231415227	GALNT7/GALNT6/PLOD3/POGLUT1/POFUT2/LFNG/FUT11/GALNT12/OGT/GALNT11/POMT1/GALNT3	0.997879877309946
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	13/1774	54/9376	1.27237045388116	AMD1/SDS/BCAT1/TST/MAT2A/LACC1/DNMT1/MAT2B/IL4I1/GCLC/GSS/AHCYL2/MTR	0.969618378015754
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	48/1774	227/9376	1.11758191001694	NFKBIA/FOS/GSTT1/PIK3R1/MAPK3/PPIF/NDUFA13/FOXO3/HMOX1/JUN/MT-ND3/MT-ND4L/SOS1/SOD1/NCF2/NFKB1/PDPK1/AHR/MAP3K5/EPHX2/PTK2/CAT/PIK3CA/HIF1A/RAF1/MAP2K1/MT-ND2/MAP2K7/MET/ABL2/EPHX3/MAP2K4/NFE2L2/GSTM4/PRKD2/COX7A2/SDHD/PLD1/PIK3R2/MAPK1/KRAS/NOX4/PTPN11/PIK3R3/MT-ATP8/UQCR10/VEGFA/MAPK8	0.866293665490067
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	67/1774	323/9376	1.09631729034105	TIMP3/SOX4/VIM/CDKN1A/CDKN2A/MARCKS/PIM1/CCNE1/PIK3R1/BMPR2/MAPK3/TGFB2/EFNA1/HMOX1/IRS2/NOTCH2/FOXP1/MDM2/ITGA5/MMP9/MCL1/DICER1/SOS1/ERBB3/BCL2L11/EP300/NFKB1/CREBBP/HNRNPK/BMI1/CD44/DNMT1/FGFR3/DDIT4/SOCS1/PRKCE/TPM1/PIK3CA/ST14/RAF1/MAP2K1/CRKL/ZEB2/SIRT1/MET/CASP3/ERBB2/TRIM71/CRK/RASSF1/EFNA5/FSCN1/ATM/MDM4/CCNG1/PTGS2/STAT3/HDAC2/RPS6KA5/MTOR/PIK3R2/PLAU/MAPK1/KRAS/PIK3R3/VEGFA/CDKN1B	0.850957304446506
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	50/1774	238/9376	1.11034267145415	IGF2/ETS2/RASGRF2/REL/PIK3R1/MAPK3/EFNA1/GNG12/TIAM1/RALGDS/SOS1/SHOC2/RAB5A/RASA1/RASGRF1/NFKB1/RASAL2/KSR1/PAK2/RAB5B/FGFR3/RGL2/INSR/PIK3CA/RAF1/MAP2K1/CSF1R/EXOC2/MET/FLT4/ABL2/TBK1/RASSF1/NF1/EFNA5/RAC2/RALGAPB/GAB1/RRAS2/PLD1/PIK3R2/GNG10/GNG4/MAPK1/KRAS/RASA2/PTPN11/PIK3R3/VEGFA/MAPK8	0.832923104613293
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	12/1774	50/9376	1.26845546786922	TGFB2/IL1B/ITGB2/LRP1/CD36/ICAM1/CD40/TNF/CCL2/MET/ITGAL/SDC2	0.919407546185779
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	8/1774	32/9376	1.32130777903044	ACOX1/ECHDC1/MLYCD/DBT/ABAT/MCEE/BCKDHB/ACOX3	0.879484779248708
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	36/1774	170/9376	1.11922541282578	CLDN19/PARD6G/TJP1/PRKAG2/PPP2CB/JUN/ITGB1/JAM2/SYNPO/AMOTL2/TIAM1/MICALL2/CLDN23/HCLS1/RAPGEF2/MAP3K5/SYMPK/TJP2/PRKCE/ARHGEF2/RUNX1/TJAP1/MAP2K7/ERBB2/MAP3K1/PRKAB2/DLG1/ROCK2/NEDD4/PRKAA1/PPP2CA/PPP2R2D/NEDD4L/RAP2C/MAPK8/CLDN12	0.757803005885703
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	47/1774	226/9376	1.09914098432621	NFKBIA/FOS/PIK3R1/MAPK3/VAV3/PDE10A/CREB5/JUN/ACOX1/CAMK2G/TIAM1/EP300/NFKB1/CREB3L2/CREBBP/CRH/PDE3B/SLC9A1/PIK3CA/ATP1B1/ATP2B3/RAF1/MAP2K1/PDE4C/RAC2/VAV2/ROCK2/PPP1CC/GLI3/GRIN3B/CREB1/PTCH1/RRAS2/PPARA/DRD1/PDE4A/PLD1/PIK3R2/ATP2A2/MAPK1/PIK3R3/CREB3L4/CAMK2D/ADCY7/MAPK8/ACOX3/GABBR2	0.728778265924152
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	45/1774	217/9376	1.09601566924184	KLF4/FOS/GSTT1/PIK3R1/MAPK3/CREB5/JUN/NOTCH2/HSP90AB1/BCL6/RXRA/SOS1/XIAP/HSP90AA1/NFKB1/CREB3L2/ATF4/RXRB/AHR/EPHX2/KPNA6/PIK3CA/ATF6B/RAF1/MAP2K1/EPHX3/RB1/RPS6KA3/IKBKE/GSTM4/CREB1/STAT3/PPARA/KLF5/ATF2/MTOR/PIK3R2/MAPK1/KRAS/JAK2/RPS6KB1/PIK3R3/CREB3L4/VEGFA/ADCY7	0.691268017479088
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	7/1774	28/9376	1.32130777903044	ELOVL4/ELOVL5/ACAA2/ELOVL1/ACOT2/MECR/PPT2	0.822506648820263
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	44/1774	212/9376	1.0969347599498	PIK3R1/MAPK3/VAV3/PARD6G/GNAQ/EFNA1/ITGB2/ITGB1/MAP2K3/TLN2/TIAM1/RALGDS/RAPGEF2/FGFR3/INSR/PIK3CA/RAF1/MAP2K1/CSF1R/CRKL/FPR1/MET/LCP2/FLT4/ITGAM/RAPGEF1/CRK/EFNA5/RAC2/VAV2/KRIT1/PRKD2/ITGAL/EVL/LPAR2/SIPA1/PIK3R2/DOCK4/MAPK1/KRAS/PLCB1/PIK3R3/VEGFA/ADCY7	0.689609828706875
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	48/1774	233/9376	1.08880297671178	FBN1/FBLN1/COL4A1/FN1/COL4A2/FMNL2/VIM/BGN/SYNE1/TNNI2/DAG1/DIAPH2/ITGA6/SUN2/ITGB1/HSPG2/TLN2/ITGA5/ITGB6/PKP2/COL11A1/DAAM1/TNNT3/MYOZ1/SYNE3/SNTB1/SGCE/TPM1/TMEM43/ATP1B1/PDLIM3/FBN2/JUP/ITGA1/NEBL/COL27A1/SSPN/SUN1/ACTG2/SDC2/ITGAV/SDC4/COL9A3/ITGA3/SPTBN5/AGRN/FMNL1/ITGA2	0.66307039481786
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	5/1774	19/9376	1.39085029371625	GCSH/GLDC/DBT/OGDH/BCKDHB	0.823791756414334
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	9/1774	38/9376	1.25176526434463	QPRT/NMNAT2/NT5E/SIRT1/NMRK1/NT5C2/SIRT6/NAMPT/NADSYN1	0.75120624174043
NA	NA	hsa04519	Cadherin signaling	81/1774	404/9376	1.05966267427194	TCF7L2/NFKBIA/KRT14/KRT7/VIM/WWTR1/MAPK3/VAV3/YWHAG/TJP1/TEAD1/MAP2K3/ANKRD6/TCF7/NCSTN/ADAM10/CYFIP2/AMOTL2/YWHAZ/WNT7A/TMC4/KRT19/KRT16/FAT2/EP300/SHOC2/NFKB1/CDH23/PKP2/CREBBP/LATS1/DAAM1/AXIN2/RERE/TEAD3/LIMA1/PTK2/TAOK1/MYO1D/TAOK3/FZD6/FZD1/STK3/RAF1/MAP2K1/TMC1/MYO1F/JUP/PSEN1/MET/FLT4/FAT1/ERBB2/WNT6/RYK/FZD7/LHFPL2/TCF7L1/RAC2/VAV2/ROCK2/PPP1CC/FZD8/RRAS2/NCKAP1L/EVL/MYO7A/WNT2B/MAPK1/WTIP/KRAS/CDH18/TMC7/GSK3B/TEAD2/DVL2/GABRE/KRT17/WNT5B/ATN1/MAPK8	0.592171196603531
Human Diseases	Cancer: specific types	hsa05218	Melanoma	16/1774	73/9376	1.15840681997189	CDKN1A/CDKN2A/PIK3R1/MAPK3/GADD45A/MDM2/PIK3CA/RAF1/MAP2K1/MET/GADD45B/RB1/PIK3R2/MAPK1/KRAS/PIK3R3	0.656330079654188
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	22/1774	103/9376	1.12888431606484	PABPC1/PPP2CB/FUS/SYMPK/WDR82/UPF2/PCF11/SMG1/PABPN1/PPP2R3C/PPP2R5E/TARDBP/PPP1CC/PNN/DDX19A/PPP2CA/PPP2R2D/RNPS1/CASC3/UPF3A/HBS1L/CSTF2T	0.635341270332658
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	17/1774	78/9376	1.15190934582141	PABPC1/EXOSC6/DCP2/CNOT6/CNOT6L/DHX36/CNOT1/PARN/DCP1B/XRN1/CNOT4/CNOT7/DDX6/XRN2/DIS3L/CNOT2/DCP1A	0.650782007456222
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	13/1774	59/9376	1.16454244931496	PIK3R1/IRS2/MGLL/FABP4/PDE3B/INSR/PIK3CA/PTGS2/PRKG1/PIK3R2/PNPLA2/PIK3R3/ADCY7	0.612441242846103
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	5/1774	20/9376	1.32130777903044	GMDS/UGP2/CYB5R1/GNE/NPL	0.694847732717216
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	7/1774	30/9376	1.23322059376174	IL1B/ABCC3/NFKB1/TNF/SHMT1/MTHFR/MTR	0.618035111951398
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	16/1774	75/9376	1.12751597143931	GPX3/GNAQ/CREB5/ITPR2/CREB3L2/ATF4/ITPR3/GPX8/ATF6B/ATP1B1/TTF2/CREB1/ATF2/PLCB1/CREB3L4/ADCY7	0.53558561818335
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	11/1774	50/9376	1.16275084554679	AOC1/OAT/AMD1/NOS2/SAT1/ALDH9A1/CNDP2/P4HA1/ALDH18A1/PYCR1/L3HYPDH	0.557389859597594
Organismal Systems	Immune system	hsa04611	Platelet activation	26/1774	126/9376	1.09060324618385	FCER1G/PIK3R1/MAPK3/GNAQ/ITGB1/ITPR2/TLN2/SNAP23/ITPR3/PIK3CA/FCGR2A/LCP2/GNA13/SYK/ROCK2/PPP1CC/STIM1/PRKG1/FERMT3/PIK3R2/MAPK1/PLCB1/ARHGEF12/PIK3R3/ADCY7/ITGA2	0.494602921841112
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	18/1774	86/9376	1.10621116383944	TCF7L2/DAG1/ITGA6/ITGB1/TCF7/ITGA5/ITGB6/PKP2/SNTB1/SGCE/JUP/ITGA1/TCF7L1/SSPN/ATP2A2/ITGAV/ITGA3/ITGA2	0.477980357468019
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	4/1774	16/9376	1.32130777903044	HEXA/ST8SIA1/NAGA/A4GALT	0.621357894396809
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	6/1774	26/9376	1.21966871910502	LMBRD1/PLB1/SCARB1/ABCD4/SLC5A6/SLC19A3	0.541810727481014
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	31/1774	154/9376	1.0639101597388	FOS/CDKN1A/MAPK3/RGS2/PRKAG2/GNAQ/JUN/ITPR2/PPP3CA/CAMK2G/ITPR3/RCAN1/PPP3R1/RAF1/MAP2K1/PRKAB2/ROCK2/PPP1CC/PTGS2/PPP1R12B/PRKAA1/NFATC3/MAPK1/KRAS/PPP3CB/PLCB1/EEF2K/CAMK2D/ADCY7/MAP2K5/CAMKK2	0.38629244803371
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	18/1774	88/9376	1.08107000102491	SERPINE1/SERPINE2/CD46/CD59/C1QB/C1QA/ITGB2/CLU/SERPING1/C1QC/SERPINA1/C2/A2M/ITGAX/C5AR1/ITGAM/C3AR1/PLAU	0.369095648054516
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	8/1774	37/9376	1.14275267375606	GMDS/UGP2/UXS1/GNE/PMM1/PMM2/GFPT1/MPI	0.420274885949341
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	16/1774	78/9376	1.0841499725378	FN1/PIK3R1/CLTB/ITGB1/ITGA5/HCLS1/PTK2/DNM2/PIK3CA/CRKL/MAD2L2/MET/CRK/GAB1/PIK3R2/PIK3R3	0.360499795186501
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	4/1774	17/9376	1.24358379202865	CYP27A1/CYP39A1/SCP2/AMACR	0.485575356289215
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	46/1774	235/9376	1.03455587804937	NDUFA13/PRKAG2/CREB5/MAP2K3/ACSL5/MT-ND3/MGLL/PRDM16/MT-ND4L/SOS1/SMARCE1/CREB3L2/ARID1A/MAP3K5/TSC1/SMARCD2/COX14/FRS2/SMARCD1/MT-ND2/PRKAB2/RPS6KA3/COX19/ARID1B/RHEB/TSC2/PRKG1/CREB1/CPT2/PRKAA1/KDM3B/DPF1/ATF2/COX7A2/SDHD/MTOR/KRAS/PNPLA2/RPS6KB1/SIRT6/CREB3L4/KDM3A/MT-ATP8/UQCR10/ADCY7/SLC25A20	0.259153764986197
NA	NA	hsa04517	IgSF CAM signaling	58/1774	299/9376	1.02522877837813	PTPRF/IL1RAP/FOXO1/EPB41L3/PIK3R1/MAPK3/VAV3/PARD6G/TJP1/ESAM/ITGB2/ITGB1/MAG/JAM2/ITGA5/ICAM1/RASA1/NLGN4X/PTPRS/RAPGEF2/PDPK1/PAK2/CD84/TJP2/PTK2/CD48/CABLES1/ITGAX/EPB41L2/NRP1/PIK3CA/MAP2K1/CSK/SRGAP2/LCP2/GRIP1/ITGAM/CD86/BAIAP2/NCK1/VAV2/DOK2/PVR/ITGAL/MBP/PIK3R2/DOK1/GIT1/MAPK1/DYNLL2/TRAF6/GSK3B/PTPN11/PIK3R3/PPFIA1/SPTBN5/MAPK8/PTPN6	0.214170258801837
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	12/1774	59/9376	1.07496226090612	ENTPD1/UPP1/ENTPD4/NT5E/TK2/RRM2B/NT5C2/DCTD/AK9/CANT1/CMPK2/CTPS2	0.279016025512166
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	12/1774	59/9376	1.07496226090612	GPX3/GSTT1/IDH1/GPX4/GPX8/RRM2B/GSTK1/GSTM4/GCLC/PGD/GSS/GGT7	0.279016025512166
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	11/1774	54/9376	1.07662115328406	FANCE/RPA1/REV1/RMI1/REV3L/WDR48/POLH/RPA4/ATR/TELO2/POLI	0.272765556286817
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	4/1774	18/9376	1.17449580358261	ACSL5/FASN/OLAH/MECR	0.357954834715976
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	27/1774	138/9376	1.03406695750208	CCNE1/MAPK3/YWHAG/PPP2CB/ITPR2/ANAPC13/CPEB2/PPP3CA/CAMK2G/YWHAZ/ANAPC16/SKP1/ITPR3/CPEB4/PPP3R1/MAP2K1/CDC23/MAD2L2/PPP2R5E/RPS6KA3/FBXW11/PPP1CC/PPP2CA/MAPK1/PPP3CB/CAMK2D/ADCY7	0.194752224197948
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	8/1774	39/9376	1.0841499725378	GCSH/GLDC/MAT2A/MAT2B/SHMT1/MTHFR/AHCYL2/MTR	0.254378918166776
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	17/1774	86/9376	1.04475498807058	GNAQ/CREB5/VAMP2/CAMK2G/CREB3L2/ATF4/ITPR3/GNA11/ATF6B/ATP1B1/CREB1/KCNMB4/ATF2/PLCB1/CREB3L4/CAMK2D/ADCY7	0.201410138286327
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	53/1774	275/9376	1.01860817874347	HSPA1B/PIK3R1/MAPK3/C1QB/C1QA/PPIF/IL1B/NDUFA13/LAMC1/CREB5/ITPR2/MT-ND3/PPP3CA/EGR1/HSPA8/MT-ND4L/SOD1/NCF2/CREB3L2/ATF4/PRNP/C1QC/TNF/HSPA6/ITPR3/CCL5/CYBB/PPP3R1/PIK3CA/ATF6B/CSNK2A2/EIF2AK3/MT-ND2/CASP3/RAC2/DDIT3/PSMA6/GRIN3B/CREB1/KLC4/ATF2/COX7A2/SDHD/PIK3R2/MAPK1/PPP3CB/GSK3B/PIK3R3/MCU/CREB3L4/MT-ATP8/UQCR10/MAPK8	0.151294859411444
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	7/1774	34/9376	1.08813581802507	CRCP/POLR2K/POLR3D/POLR2J3/POLR2M/POLR3K/POLR3A	0.248696961993054
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	9/1774	45/9376	1.05704622322435	ABCA1/ABCD1/ABCG1/ABCC3/ABCA4/TAP1/ABCB10/ABCD4/ABCC10	0.185296652033975
Organismal Systems	Digestive system	hsa04978	Mineral absorption	12/1774	61/9376	1.03971759661412	MT1X/MT1H/MT1G/MT1F/MT1M/HMOX1/FTL/MT2A/ATP1B1/ATP2B3/TRPM7/ATP7A	0.150333220727014
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	11/1774	56/9376	1.03817039780963	MAN1A1/MAN2A1/GANAB/FUT8/MGAT5/MGAT2/RPN2/ALG13/ALG8/ALG6/ALG10	0.138392086400218
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	7/1774	35/9376	1.05704622322435	GMDS/FBP1/PMM1/PMM2/AKR1B1/PFKFB4/MPI	0.163328790674643
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	10/1774	51/9376	1.03631982669054	GDPD3/LPCAT1/PAFAH1B2/PLD3/PLB1/PAFAH2/GDPD1/CEPT1/PLA2G7/PLD1	0.125632773834839
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	19/1774	99/9376	1.01433728491226	DAG1/TGFB2/ITGA6/PRKAG2/ITGB1/ITGA5/ITGB6/TNF/SNTB1/SGCE/TPM1/ITGA1/PRKAB2/SSPN/PRKAA1/ATP2A2/ITGAV/ITGA3/ITGA2	0.0692754328421792
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	21/1774	110/9376	1.00899866762324	PIK3R1/MAPK3/ANAPC13/CPEB2/HSP90AB1/ANAPC16/HSP90AA1/PDE3B/CPEB4/PIK3CA/RAF1/MAP2K1/CDC23/MAD2L2/RPS6KA3/PIK3R2/MAPK1/KRAS/PIK3R3/ADCY7/MAPK8	0.0458592469424656
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	17/1774	89/9376	1.00953852779854	MAPK3/TJP1/GNAQ/ITPR2/MAP3K2/SOS1/ITPR3/GNA11/RAF1/MAP2K1/PRKG1/DRD1/MAPK1/KRAS/PLCB1/ADCY7/MAP2K5	0.0436754253868637
NA	NA	hsa04382	Cornified envelope formation	41/1774	217/9376	0.99859205419812	COL4A1/COL17A1/COL4A2/KRT14/KRT7/CLDN19/PCSK6/ITGA6/TJP1/PPP2CB/S100A9/DST/KRT19/KRT16/ELOVL4/CLDN23/S100A4/PKP2/EPHX2/SLC27A1/LAMC2/UGCG/S100A8/ST14/ELOVL1/LAMA5/S100A5/GBA2/JUP/KDSR/PPP2R3C/PPP2R5E/EPHX3/PPP2CA/SPTLC2/PPP2R2D/PRSS8/KAZN/KRT17/CLDN12/S100A13	-0.0101365528238101
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	22/1774	116/9376	1.00237141857482	SLC17A8/MAPK3/GNAQ/HOMER3/ITPR2/GLUL/GNG12/PPP3CA/ITPR3/PPP3R1/HOMER1/SLC38A1/SLC38A2/GRIN3B/PLD1/GNG10/GNG4/MAPK1/PPP3CB/SLC1A3/PLCB1/ADCY7	0.0124145285581631
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	7/1774	36/9376	1.02768382813479	GALNT7/GALNT6/B4GALT5/B3GNT3/GALNT12/GALNT11/GALNT3	0.080390081693188
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	7/1774	36/9376	1.02768382813479	RPA1/MCM3/RFC1/MCM4/PRIM2/POLE3/RPA4	0.080390081693188
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	4/1774	20/9376	1.05704622322435	SOAT1/MSMO1/DHCR24/LIPA	0.123365948335057
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	6/1774	31/9376	1.02294795795905	ACOX1/MLYCD/ABAT/ALDH9A1/CNDP2/ACOX3	0.0618206764629846
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	18/1774	97/9376	0.980764537012285	FOS/MAPK3/GNAQ/GNG12/CAMK2G/PER2/ITPR3/PRKG1/CREB1/RPS6KA5/GNG10/GNG4/MAPK1/CACNA1G/PLCB1/CAMK2D/RASD1/ADCY7	-0.0919891142459711
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	4/1774	21/9376	1.0067106887851	BCAT1/AASDHPPT/PANK1/PANK3	0.0148714516410907
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	8/1774	43/9376	0.983298812301723	ACSL5/ACOX1/ACAA2/ALDH9A1/ACADVL/CPT2/ACAA1/ACOX3	-0.0530236310841725
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	38/1774	205/9376	0.97970137762257	MPC1/PIK3R1/CTSD/PPIF/TGFB2/NDUFA13/TGFBR1/MT-ND3/MMP9/CAMK2G/CD36/MT-ND4L/NCF2/NFKB1/CYBB/INSR/PIK3CA/SP1/MT-ND2/SMAD2/RAC2/PPP1CC/CPT2/PPARA/COX7A2/SDHD/PDK4/MTOR/PIK3R2/ATP2A2/GFPT1/GSK3B/PLCB1/PIK3R3/CAMK2D/MT-ATP8/UQCR10/MAPK8	-0.141949432770974
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/1774	10/9376	1.05704622322435	TST/SUOX	0.0871863172795086
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	7/1774	38/9376	0.973595205601377	CD40/BLNK/PTPRC/DCLRE1C/TAP1/CD4/IL2RG	-0.0787854766850085
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	18/1774	99/9376	0.960951112022138	IL1RAP/PIK3R1/IL1B/GNAQ/MAP2K3/ITPR2/CAMK2G/ITPR3/PRKCE/PTGER4/PIK3CA/PPP1CC/PIK3R2/PLCB1/PIK3R3/CAMK2D/ADCY7/MAPK8	-0.188677886589224
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	4/1774	22/9376	0.960951112022138	AOC1/HNMT/ALDH9A1/CNDP2	-0.088576770442842
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	10/1774	56/9376	0.943791270736028	MEGF8/IQCE/FBXW11/GLI3/CSNK1G3/PTCH1/CUL3/SPOPL/HHAT/GSK3B	-0.203792566049267
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	3/1774	17/9376	0.932687844021487	ADO/FMO4/GGT7	-0.13418431435708
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	3/1774	17/9376	0.932687844021487	SEPHS2/TXNRD3/MTR	-0.13418431435708
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	11/1774	63/9376	0.922818131386339	POLR2K/DDB1/RPA1/XPC/POLR2J3/POLR2M/RFC1/POLE3/RPA4/CETN2/ERCC5	-0.296919879359626
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	7/1774	41/9376	0.902356532020788	GCSH/PIPOX/GLDC/AGXT/SDS/BPGM/SHMT1	-0.30267494786764
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	18/1774	103/9376	0.923632622234871	COL4A1/COL17A1/COL4A2/PRCP/COL21A1/COL12A1/DPP4/SLC7A9/SLC1A5/COL11A1/MME/ATP1B1/SLC38A2/COL27A1/KCNQ1/SLC7A7/KCNE3/COL9A3	-0.376456564170782
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/1774	12/9376	0.88087185268696	CD46/NPC1	-0.199467810921979
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	9/1774	53/9376	0.897492076322563	CLTB/GNAQ/DNM2/AP2A2/ATP1B1/ATP2B3/AP2B1/PLCB1/PTH1R	-0.361506443747621
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	13/1774	76/9376	0.904052690915564	GNAQ/CA2/ITPR2/CAMK2G/ITPR3/SLC9A1/ATP1B1/KCNQ1/SLC4A2/KCNJ15/PLCB1/CAMK2D/ADCY7	-0.4056921779858
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	27/1774	154/9376	0.926631429449919	MAPK3/GNAQ/CREB5/PPP2CB/CAMK2G/CREB3L2/ATF4/TPM1/SLC9A1/ATF6B/ATP1B1/ATP2B3/PPP2R3C/PPP2R5E/PPP1CC/CREB1/PPP2CA/RPS6KA5/ATF2/KCNQ1/ATP2A2/PPP2R2D/MAPK1/PLCB1/CREB3L4/CAMK2D/ADCY7	-0.443461960388757
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	7/1774	42/9376	0.88087185268696	AOC1/AADAT/CAT/ALDH9A1/IL4I1/ASMT/KMO	-0.373769317821454
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	11/1774	65/9376	0.894423727343682	DGKH/MGLL/LPL/LIPG/AGPAT1/LPIN2/LPIN1/ALDH9A1/AKR1B1/PNPLA2/AGPAT4	-0.412594423219207
NA	NA	hsa04981	Folate transport and metabolism	5/1774	31/9376	0.852456631632542	ABCC3/SHMT1/SLCO2B1/MTHFR/MTR	-0.397474618716843
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	6/1774	37/9376	0.857064505317042	GLUL/AGXT/ABAT/GPT/IL4I1/GFPT1	-0.42081312486411
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	6/1774	37/9376	0.857064505317042	IL1B/GNAQ/APOL1/ICAM1/TNF/PLCB1	-0.42081312486411
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	2/1774	13/9376	0.813112479403348	DCLRE1C/POLM	-0.325718915514047
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	5/1774	32/9376	0.825817361894025	GAA/UGP2/GALM/GLB1/AKR1B1	-0.476773327697984
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	7/1774	44/9376	0.840832223019371	MAN1A1/HEXA/MAN2A1/FUT8/MGAT2/RPN2/ALG13	-0.511202109434086
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	7/1774	44/9376	0.840832223019371	PARP4/TDG/RFC1/POLB/POLE3/PARG/TDP1	-0.511202109434086
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	4/1774	26/9376	0.813112479403348	ACOX1/PLB1/ACAA1/ACOX3	-0.460956224919694
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	14/1774	85/9376	0.870508654420054	ENTPD1/UPP1/LACC1/ENTPD4/NT5E/TK2/RRM2B/NT5C2/DCTD/GDA/AK9/CANT1/CMPK2/CTPS2	-0.579318623235624
Organismal Systems	Endocrine system	hsa04924	Renin secretion	11/1774	69/9376	0.842573076483179	CTSB/GNAQ/ITPR2/PPP3CA/ITPR3/PDE3B/PPP3R1/PTGER4/CREB1/PPP3CB/PLCB1	-0.634011609135597
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	12/1774	75/9376	0.845636978579481	IDH1/GLUL/SDS/BCAT1/MAT2A/GPT/MAT2B/ACO1/SHMT1/ALDH18A1/PYCR1/MTR	-0.648347131100416
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	19/1774	116/9376	0.865684406950978	GCSH/IDH1/GLDC/ACOX1/AGXT/FBP1/H6PD/SDS/CAT/GPT/OGDH/ACO1/MCEE/ME2/ADPGK/SHMT1/SDHD/PGD/ACOX3	-0.703150756859914
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	17/1774	105/9376	0.855704085467332	DAG1/TGFB2/ITGA6/ITGB1/ITGA5/ITGB6/TNF/SNTB1/SGCE/TPM1/ITGA1/SSPN/ATP2A2/ITGAV/ITGA3/ADCY7/ITGA2	-0.71826368175669
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	4/1774	28/9376	0.755033016588823	ST8SIA1/B3GNT3/ST3GAL6/A4GALT	-0.627084016468983
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	63/1774	368/9376	0.904808587814323	GPX3/MAP1LC3B/NDUFA13/MAP2K3/MT-ND3/PPP3CA/FUS/MT-ND4L/RAB5A/SOD1/NOS2/ATF4/ANXA11/SQSTM1/TNF/MAP3K5/RAB1A/DCTN4/ITPR3/CAT/SETX/NUP153/GPX8/PPP3R1/ATXN2/ATXN2L/DCTN1/EIF2AK3/DCTN6/MT-ND2/MATR3/UBQLN1/CASP3/TARDBP/TBK1/POM121/SPG11/NUP50/OPTN/DDIT3/PSMA6/UBQLN2/KLC4/NUP62/WIPI1/NUP214/COX7A2/SDHD/MTOR/ULK2/DNAH11/ATF6/ATG14/PPP3CB/RB1CC1/ATG2B/ATG13/MCU/NUP133/MT-ATP8/UQCR10/XBP1/FIG4	-0.899924351199589
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	17/1774	108/9376	0.831934527537684	EEF1A1/TNPO1/KPNA6/NUP153/UPF2/POM121/NUP50/XPOT/PNN/DDX19A/NUP62/NUP214/RNPS1/CASC3/RANGAP1/NUP133/UPF3A	-0.84858603268348
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	3/1774	23/9376	0.689377971668055	GLUL/NOS2/GPT	-0.720475497259346
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	3/1774	23/9376	0.689377971668055	CHST10/FKRP/POMT1	-0.720475497259346
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	3/1774	23/9376	0.689377971668055	RPA1/RFC1/RPA4	-0.720475497259346
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	3/1774	23/9376	0.689377971668055	PRCP/CTSA/MME	-0.720475497259346
Human Diseases	Substance dependence	hsa05032	Morphine addiction	14/1774	91/9376	0.813112479403348	PDE10A/GRK4/GNG12/PDE3B/PDE7A/PDE4C/DRD1/PDE4A/PDE8A/GNG10/GNG4/GABRE/ADCY7/GABBR2	-0.865383395212494
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	4/1774	30/9376	0.704697482149568	IDH1/OGDH/ACO1/SDHD	-0.78255235412731
NA	NA	hsa04081	Hormone signaling	36/1774	219/9376	0.868805114978919	CSH2/CSH1/IGF2/PIK3R1/GNAQ/IRS2/DIO2/GNG12/THRB/HAMP/CRH/OPRK1/CSHL1/SMAD4/SMAD1/INSR/GNA11/PIK3CA/ACVR1/GNA13/PRKG1/STAT3/DRD1/PIK3R2/GNG10/GNG4/ITGAV/GH2/PLCB1/JAK2/PIK3R3/MC1R/ADCY7/VIPR1/PRLR/PTH1R	-0.948988319261852
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/1774	17/9376	0.621791896014324	CA2/GLUL	-0.753943985003375
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/1774	17/9376	0.621791896014324	DAG1/LAMP2	-0.753943985003375
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	21/1774	134/9376	0.82828248834744	MAPK3/GNAQ/ITPR2/CALD1/ITPR3/PRKCE/GNA11/RAF1/MAP2K1/GNA13/ROCK2/PPP1CC/PRKG1/PPP1R12B/ACTG2/KCNMB4/MAPK1/PLCB1/ARHGEF12/ADM/ADCY7	-0.967124793031151
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	51/1774	308/9376	0.87515190559159	GPX3/PPIF/CLTB/NDUFA13/GNAQ/CREB5/HIP1/MT-ND3/MT-ND4L/EP300/POLR2K/SOD1/CREB3L2/CREBBP/MAP3K5/DCTN4/AP2A2/GPX8/SP1/DCTN1/DCTN6/TBP/MT-ND2/MAP2K7/BBC3/CASP3/AP2B1/POLR2J3/PSMA6/CREB1/KLC4/REST/WIPI1/HDAC2/COX7A2/SDHD/MTOR/ULK2/DNAH11/ATG14/SLC1A3/PLCB1/SIN3A/RB1CC1/ATG2B/ATG13/CREB3L4/MT-ATP8/UQCR10/MAPK8/TAF4	-1.07621746068827
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	24/1774	154/9376	0.823672381733261	QPRT/NMNAT2/RFK/UGP2/BCAT1/MAT2A/GUSB/CPOX/MAT2B/EARS2/PANK1/PANK3/AK9/COQ7/SHMT1/KMO/PMM1/GCLC/PMM2/CMPK2/GSS/CTPS2/NADSYN1/MPI	-1.06577776670561
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	13/1774	89/9376	0.77200005066947	GABARAPL2/GABARAP/GLUL/GNG12/GABARAPL1/SLC38A1/ABAT/SLC38A2/GNG10/GNG4/GABRE/ADCY7/GABBR2	-1.04397607109982
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	7/1774	52/9376	0.711473419477929	LDLR/SCARB1/INSR/ACOT2/PTGS2/ALOX5/ADCY7	-1.0078244296456
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	6/1774	46/9376	0.689377971668055	HMOX1/FTL/GUSB/BLVRA/CPOX/EARS2	-1.02016133309343
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	17/1774	115/9376	0.78129503455713	MAPK3/DUSP1/GNAQ/ITPR2/GNG12/SLC6A4/ITPR3/RAF1/MAP2K1/CASP3/PTGS2/ALOX5/GNG10/GNG4/MAPK1/KRAS/PLCB1	-1.13992724760064
Cellular Processes	Cell motility	hsa04814	Motor proteins	30/1774	194/9376	0.817303780843571	TNNI2/DYNLT1/DYNC1I2/KIF21A/MYO7B/KIF12/TNNT3/DCTN4/TPM1/MYO1D/DCTN1/MYO1F/MYO6/DCTN6/HOOK3/MYO9A/DYNC1LI2/KIF1C/KIF3B/KLC4/ACTG2/KIF19/MYO9B/MYO7A/DNAH11/DYNLL2/MYO5B/KIF26A/MYO5C/MYL10	-1.24211067409906
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	6/1774	48/9376	0.66065388951522	PIK3R1/PIK3CA/ATP1B1/PIK3R2/PLCB1/PIK3R3	-1.13859098020904
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	30/1774	195/9376	0.813112479403348	PIK3R1/MAPK3/PPIF/ITGB2/FCGR3A/NCF2/NFKB1/AQP9/FPR3/CYBB/PIK3CA/C5AR1/RAF1/MAP2K1/MAP3K7/FCGR2A/FPR1/FCGR1A/ITGAM/SYK/RAC2/ELANE/ITGAL/CLCN3/HDAC2/MTOR/PIK3R2/MAPK1/PLCB1/PIK3R3	-1.27394631719962
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/1774	12/9376	0.44043592634348	COQ7	-0.936932398936364
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	40/1774	254/9376	0.832319860806576	PPIF/GNAQ/CXCR4/P2RX4/ITPR2/PLCD3/PPP3CA/CAMK2G/ERBB3/NOS2/PHKA2/CHRM5/FGFR3/ITPR3/MCOLN1/GNAL/PPP3R1/GNA11/PHKB/ATP2B3/ASPH/MET/STIM2/FLT4/ERBB2/ORAI3/STIM1/GRIN3B/DRD1/NFATC3/ATP2A2/ITPKC/TPCN1/PPP3CB/CACNA1G/PLCB1/MCU/CAMK2D/VEGFA/ADCY7	-1.30873574257343
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	22/1774	149/9376	0.780369694997844	SLC17A8/MAPK3/NDUFA13/GNAQ/ITPR2/MT-ND3/GNG12/MGLL/MT-ND4L/FAAH/ITPR3/MT-ND2/PTGS2/NAPEPLD/DAGLB/GNG10/GNG4/MAPK1/PLCB1/GABRE/ADCY7/MAPK8	-1.30543018915544
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	21/1774	143/9376	0.77615282124865	HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-DRB1/HLA-DQB1/C1QB/HLA-DQA1/C1QA/FCGR3A/HLA-DMB/HLA-DMA/CD40/C1QC/HLA-DRB5/TNF/HLA-DQA2/C2/FCGR2A/FCGR1A/CD86/ELANE	-1.30300697172805
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	4/1774	36/9376	0.587247901791307	UGP2/DCXR/GUSB/AKR1B1	-1.1985761048826
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	4/1774	36/9376	0.587247901791307	GAA/UGP2/PGM2L1/AGL	-1.1985761048826
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	5/1774	43/9376	0.614561757688577	ABCA1/CD36/SCARB1/SLC27A1/AGPAT1	-1.22370549539784
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	42/1774	268/9376	0.82828248834744	SLC39A8/SLC39A11/DUSP1/PPIF/NDUFA13/UBB/ITPR2/MT-ND3/CAMK2G/MT-ND4L/SOD1/TH/ATF4/SLC39A13/MAP3K5/ITPR3/UBE2G2/GNAL/UBA7/SLC39A7/EIF2AK3/UBC/MT-ND2/CASP3/SLC39A9/NFE2L2/GPR37/DDIT3/PSMA6/KLC4/DRD1/COX7A2/SDHD/ATF6/UBE2J1/MCU/CAMK2D/MT-ATP8/UQCR10/MAPK8/XBP1/UBE2L6	-1.37774545137315
Organismal Systems	Digestive system	hsa04976	Bile secretion	12/1774	90/9376	0.704697482149568	CA2/ABCC3/RXRA/LDLR/SCARB1/AQP9/SLC9A1/ATP1B1/HMGCR/SLC4A2/ADCY7/NCEH1	-1.35979230218191
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/1774	14/9376	0.377516508294411	FUT8	-1.12591615654085
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/1774	23/9376	0.45958531444537	CA2/ATP1B1	-1.25347046824748
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	3/1774	31/9376	0.511473978979525	FBP1/H6PD/PGD	-1.3160652090765
Organismal Systems	Digestive system	hsa04970	Salivary secretion	12/1774	93/9376	0.681965305306033	LYZ/GNAQ/VAMP2/ITPR2/ITPR3/SLC9A1/ATP1B1/ATP2B3/PRKG1/SLC4A2/PLCB1/ADCY7	-1.48891639635548
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	19/1774	138/9376	0.727676747871836	NDUFA13/ATP6V1G1/MT-ND3/MT-ND4L/ATP6V0D1/ATP6V0E1/ATP6V1H/LHPP/ATP6V1A/ATP6V1D/ATP6V0A1/MT-ND2/ATP6AP1/ATP6V1E1/COX7A2/SDHD/ATP6V1B2/MT-ATP8/UQCR10	-1.55680351113055
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	13/1774	102/9376	0.673607887348852	GNAQ/RAB27B/CA2/ITPR2/ITPR3/SLC9A1/ATP1B1/ATP2B3/KCNQ1/ATP2A2/SLC4A2/PLCB1/ADCY7	-1.60104931376155
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	17/1774	128/9376	0.701944757609921	PDE10A/ENTPD1/LACC1/ENTPD4/NT5E/PDE3B/RRM2B/PDE7A/PDE6H/PDE4C/NT5C2/GDA/AK9/CANT1/PDE4A/PDE8A/ADCY7	-1.64012274914389
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/1774	16/9376	0.33032694475761	IL4I1	-1.29504066411124
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	7/1774	63/9376	0.587247901791307	HPGD/PTGES/GPX4/PLB1/EPHX2/PTGS2/ALOX5	-1.58786390387892
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	2/1774	27/9376	0.391498601194204	HMGCS1/ABAT	-1.52953491941426
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/1774	28/9376	0.377516508294411	TH/AKR1B1	-1.59347779332848
Human Diseases	Substance dependence	hsa05034	Alcoholism	26/1774	191/9376	0.719455544602962	FOSB/SLC29A1/MAPK3/CREB5/GNG12/SOS1/TH/CREB3L2/ATF4/CRH/ATF6B/RAF1/MAP2K1/SLC29A3/PPP1CC/GRIN3B/CREB1/DRD1/HDAC2/ATF2/GNG10/GNG4/MAPK1/KRAS/CREB3L4/CAMKK2	-1.89224473909434
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	4/1774	47/9376	0.449806903499724	GLO1/HAGH/ALDH9A1/ME2	-1.82660664217475
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	2/1774	31/9376	0.340982652653017	GUSB/ALDH9A1	-1.77536050425633
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/1774	31/9376	0.340982652653017	SEC63/IMMP1L	-1.77536050425633
Genetic Information Processing	Transcription	hsa03040	Spliceosome	33/1774	243/9376	0.717747435522708	HSPA1B/DDX5/HSPA8/FUS/SRSF2/HNRNPK/TRA2A/SRSF6/PRPF6/HSPA6/CDC5L/SF1/HNRNPU/SLU7/SNRNP27/CWC25/DHX38/CDC40/DHX8/SNIP1/PRPF18/SNRPB2/DHX15/SMNDC1/RBMXL1/CRNKL1/DDX42/DHX16/PPIL1/PHF5A/CASC3/AQR/ISY1	-2.15344020833087
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	3/1774	41/9376	0.386724228008909	RPA1/ATM/RPA4	-1.90103051599323
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	3/1774	41/9376	0.386724228008909	SLC17A8/GRIN3B/GABRE	-1.90103051599323
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	8/1774	82/9376	0.515632304011879	GSTT1/UPP1/GUSB/TK2/RRM2B/CES2/GSTM4/CES1	-2.12803749818267
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	6/1774	70/9376	0.453019809953294	GSTT1/GSTK1/GSTM4/PTGS2/SULT1A1/SULT1A3	-2.2188993708508
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	3/1774	46/9376	0.344688985834028	PSMB8/PSMB10/PSMA6	-2.15220717407702
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/1774	37/9376	0.285688168439014	TH/IL4I1	-2.10298914649101
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	5/1774	67/9376	0.3944202325464	FBP1/BPGM/GALM/ALDH9A1/ADPGK	-2.40301098642796
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/1774	29/9376	0.182249348831785	SLC24A1	-2.1305036841749
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/1774	30/9376	0.176174370537392	PLB1	-2.18313982020602
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	7/1774	87/9376	0.425248480607498	TPM1/SLC9A1/ATP1B1/ASPH/COX7A2/ATP2A2/UQCR10	-2.60167944775629
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4/1774	73/9376	0.289601704992973	GSTT1/FMO4/GSTK1/GSTM4	-2.94340716915404
NA	NA	hsa04082	Neuroactive ligand signaling	20/1774	199/9376	0.531179006645403	SLC17A8/SLC6A2/GNAQ/P2RX4/GNG12/TAC3/OPRK1/SLC6A4/CHRM5/GNAL/GNA11/GRIN3B/DRD1/GNG10/GNG4/SLC1A3/PLCB1/GABRE/ADCY7/GABBR2	-3.22910179770434
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3/1774	68/9376	0.233171961005372	RDH10/DHRS4L2/ALDH1A1	-3.06565138425571
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3/1774	79/9376	0.200704979093231	GSTT1/GSTK1/GSTM4	-3.44625771286234
Organismal Systems	Sensory system	hsa04742	Taste transduction	3/1774	86/9376	0.184368527306573	ITPR3/PLCB1/GABBR2	-3.67057293025737
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	11/1774	183/9376	0.317691487854313	SBDS/CSNK2A2/UTP14C/REXO2/XRN1/FCF1/GNL3L/SNORD3A/XRN2/MDN1/SNORD3D	-4.50273323070461
Genetic Information Processing	Translation	hsa03010	Ribosome	14/1774	222/9376	0.33330286317885	RPS4Y1/RPS10/RPS12/RPS27L/RPL10A/RPL26/RPL27A/RPL36A/RPS8/RPL17/RPS21/RPS29/MRPS18B/MRPL49	-4.85621757664661
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	29/1774	370/9376	0.41424784423657	CSH2/CSH1/KISS1/P2RX4/TAC3/THRB/NPB/NR3C1/CRH/OPRK1/CSHL1/CHRM5/FPR3/PTGER4/PGRMC1/C5AR1/FPR1/C3AR1/GRIN3B/DRD1/LPAR2/GH2/GABRE/ADM/MC1R/VIPR1/PRLR/GABBR2/PTH1R	-5.5532509510416
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	8/1774	449/9376	0.0941689285723253	RGS2/NCALD/CAMK2G/GNAL/PRKG1/ANO2/OR5AC2/CAMK2D	-9.5020241531096