category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	131/2452	250/9376	2.00368026101142	CTSC/GNPTG/CD63/LAPTM4A/CTSD/SCARB2/CTSO/NEU1/AP2M1/NAGLU/LAPTM4B/DEPTOR/FUCA2/ROGDI/HYAL2/CTSA/PLA2G15/ATP6V0D1/ATP6V1G1/ARL8A/CD68/VPS35/CLCN7/HEXA/SMPD1/CLTC/ASAH1/CTBS/GUSB/CTSF/MCOLN2/GALNS/IGF2R/RRAGA/M6PR/HEXB/DMXL2/RRAGB/OSBPL1A/AP2A1/ACP2/AP3M2/GGA2/SLC29A3/PPT1/GLA/BLOC1S6/DMXL1/SORT1/LAMP2/MANBA/BLOC1S5/PIKFYVE/SLC11A2/CTSS/ZFYVE26/TPCN1/TLR3/ENTPD4/TMEM175/ATP6V1C1/ARSB/VPS13C/VPS16/NAGA/CTSZ/MCOLN1/SPG11/TELO2/NPC1/LAMP1/VPS11/SUMF1/AP4S1/ABCA2/GLB1/HGSNAT/LAPTM5/ATP6AP1/TFE3/TCIRG1/MFSD8/LAMTOR3/AP2B1/RAB7A/VAMP7/TPP1/STX17/SGSH/GNS/OSBPL2/ATP6V0A1/ATP6V1D/AP3M1/GPR155/LAMTOR5/LIPA/ABCA5/AP1G1/MLST8/RRAGC/OSBPL5/AKT1S1/BLOC1S1/SNAPIN/ACP5/AP1S2/BLOC1S4/NAGPA/SLC17A5/AP3D1/VPS39/IDUA/ARSA/LITAF/FUCA1/BLOC1S3/CTNS/AP5Z1/SLC2A6/OSBPL7/CTSB/AP1M1/VPS18/OSBP/SLC15A4/GGA3/ATP6V0B/PLEKHM1/AP5M1/ATP6V0A2	9.57177534168291
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	89/2452	169/9376	2.01372626620462	GABARAPL2/UBB/RRAS/CTSD/IRS1/ITPR1/OPTN/DEPTOR/TSC2/PIK3R1/DAPK1/NBR1/IGF1R/UVRAG/EIF2AK4/PPP2CB/RB1CC1/WIPI2/AKT2/KRAS/GABARAPL1/PDPK1/STK11/GORASP2/RRAGA/GABARAP/PIK3CA/TAX1BP1/PRKACA/ULK2/RRAGB/SUPT20H/DDIT4/BCL2/PTEN/CALCOCO2/MAPK1/PRKACB/LAMP2/PRKAA1/ULK1/PIK3C3/WDFY3/VPS16/RPS6KB1/LAMP1/MRAS/VPS11/RAB33B/RAF1/ATG14/WDR45/CAMKK2/RHEB/RAB7A/STX17/MAP3K7/PIK3R4/TSC1/MTMR3/BIRC6/BCL2L1/ATG4D/MAPK10/AMBRA1/MLST8/SQSTM1/MAPK8/RRAGC/MAP1LC3B/ATG2B/SH3GLB1/ZFYVE1/WDR41/AKT1S1/MAP2K2/EPG5/AKT3/HIF1A/EIF2AK3/TRAF6/VPS39/PIK3R2/ATG4B/CTSB/VPS18/PLEKHM1/RAB1A/PRKCD	7.91356769329552
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	103/2452	224/9376	1.75827312980657	HLA-B/CCND2/CREB3L1/HLA-A/TNFRSF1A/TGFBR2/TGFBR1/MSX1/CCND3/IL1R1/ADCY3/HLA-DRA/CREBBP/HLA-F/PIK3R1/HLA-C/SMAD3/ADCY9/NRP1/B2M/CDK4/NFATC4/LTBR/TGFB3/CCND1/SMAD4/HLA-E/AKT2/KRAS/HLA-DPA1/JUN/CREB1/PIK3CA/ATM/PRKACA/NFATC3/FOS/CDKN1A/TGFB2/ATF2/JAK3/HLA-DPB1/CHEK2/NFATC2/MYC/PPP3CB/HLA-DQA2/HLA-DMA/TLN2/PTEN/MAPK1/ADCY7/PRKACB/ATF6B/ELK4/DLG1/PPP3CC/CDC16/MAP2K4/ANAPC16/MAP3K3/ADCY6/CREB3/MAP3K1/ANAPC13/NFKB1/KAT2B/RANBP3/CDC27/HLA-DMB/CRTC1/KAT5/XIAP/STAT5A/ANAPC10/TRRAP/BCL2L1/MAPK10/HLA-DRB1/MAPK8/ETS1/CDKN2B/MAP2K2/ATR/TSPO/TCF3/NFKB2/AKT3/CD4/STAT5B/ZFP36/IKBKG/MAD1L1/MMP7/PIK3R2/PPP3R1/IKBKB/HLA-DQA1/NFATC1/RELA/ATF4/CDC23/ITGB2	6.83532252431826
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	112/2452	250/9376	1.71307014681892	HLA-B/PDGFRA/HLA-A/TGFBR2/TGFBR1/BIN1/RAB11FIP1/ARAP1/AP2M1/EHD2/HLA-F/RAB11FIP2/HLA-C/SMAD3/FGFR2/TFRC/WASL/ARFGAP3/SMURF2/IGF1R/IST1/VPS35/FGFR4/PSD3/HLA-E/HSPA1A/CLTC/ASAP1/ARF1/RAB22A/CAPZA2/IGF2R/PLD1/ARAP3/ARFGEF2/AP2A1/WIPF1/CAV2/SH3GL3/AGAP3/RAB5A/ACAP3/SNX1/LDLRAP1/VPS28/PRKCI/PML/FGFR3/CHMP1A/KIF5B/RUFY2/USP8/ZFYVE16/DNM1/SMAP2/AGAP1/RUFY1/RABEP1/RAB11FIP3/VPS4A/VPS36/HSPA1B/ACAP2/CHMP5/ASAP2/WWP1/EPS15L1/GIT2/ARFGAP1/GRK5/AP2B1/RAB7A/DAB2/STAM2/RNF41/ARFGEF1/ARRB1/RAB11B/CYTH3/AGAP6/SNX6/STAMBP/NEDD4L/STAM/PSD/SH3GLB1/ARFGAP2/CYTH1/CYTH2/HSPA6/PDCD6IP/SMAP1/WIPF2/NEDD4/EEA1/VPS37A/ZFYVE9/CHMP6/MVB12B/PIP5K1C/TRAF6/GBF1/ACAP1/VPS4B/VPS37D/PARD6G/PARD3/PIP5K1A/ZFYVE27/SRC/VPS45/HGS	6.80032029456633
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	58/2452	105/9376	2.11220383748932	GABARAPL2/UBB/AMFR/RRAS/OPTN/FOXO3/BNIP3L/SMURF2/NBR1/KRAS/GABARAPL1/JUN/GABARAP/TAX1BP1/TBC1D15/PINK1/RAB5A/CALCOCO2/MUL1/USP8/ULK1/CSNK2A1/SP1/CITED2/MRAS/NLRX1/FKBP8/RHOT1/TFE3/ARIH1/CCZ1/RAB7A/RHOT2/TBC1D17/MTX2/CSNK2B/SIAH1/MTX3/BCL2L1/MAPK10/AMBRA1/CSNK2A2/SQSTM1/MAPK8/FUNDC1/MAP1LC3B/USP30/MFN2/SAMM50/HIF1A/EIF2AK3/RELA/OPA1/MON1A/ATF4/CCZ1B/SRC/MON1B	6.81997982199331
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	123/2452	300/9376	1.56776508972268	HGF/PDGFRA/TNFRSF1A/TGFBR2/TGFBR1/FGF7/CSF1/IGF2/RRAS/IL1R1/KITLG/PDGFC/VEGFA/PDGFA/PRKCA/VEGFC/MAPK14/PDGFRB/GDNF/FGFR1/FGF2/FGFR2/IGF1R/CACNA2D1/EFNA5/TEK/DUSP7/FGFR4/MAP2K5/TGFB3/GADD45B/FAS/ANGPT1/HSPA1A/AKT2/CDC25B/KRAS/JUN/TAOK1/TAOK2/MAP4K3/PRKACA/NFATC3/BDNF/FOS/TGFB2/FLNA/TRADD/ATF2/SOS1/MAPKAPK3/MAPK7/MYC/PPP3CB/HSPB1/PPM1A/MAP3K2/JUND/MAPK1/PRKACB/CACNB4/FGFR3/TAB2/ELK4/PPP3CC/MAP3K12/EFNA2/RPS6KA3/MAP2K4/NRTN/RAP1A/MAP3K3/GADD45G/MAX/HSPA1B/ARAF/MAP3K1/NFKB1/MRAS/FLT3LG/RAF1/RPS6KA4/DUSP8/LAMTOR3/RAPGEF2/MAP3K7/CACNB2/MAP4K4/CRK/ARRB1/MAPK10/SOS2/PLA2G4A/MAPK8/VEGFB/MAP2K7/HSPA6/NTF3/MAP2K2/IRAK4/CACNA1C/NFKB2/AKT3/CACNA1G/DDIT3/IKBKG/TRAF6/MAP3K6/PPP3R1/IKBKB/NTRK2/CACNB1/CACNB3/NFATC1/RELA/PSPN/PPP5C/MAPKAPK2/GNG12/ATF4/CASP3/DUSP10/NF1	5.94770487553962
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	74/2452	157/9376	1.80230878731518	HLA-B/CCND2/HLA-A/TGFBR2/TGFBR1/IGFBP3/CALM2/ZFP36L2/RRAS/ZFP36L1/GATA4/CCND3/CAPN2/HLA-F/ITPR1/CDK6/RBL2/TSC2/PIK3R1/MAPK14/HLA-C/SMAD3/FOXO3/HIPK3/EIF4EBP1/HIPK2/CDK4/NFATC4/TGFB3/CCND1/GADD45B/HLA-E/AKT2/KRAS/PIK3CA/ATM/NFATC3/CDKN1A/TGFB2/CHEK2/NFATC2/MYC/PPP3CB/ITPR2/PTEN/MAPK1/RAD50/RASSF5/TRPM7/FBXW11/PPP3CC/HIPK1/SERPINE1/GADD45G/NFKB1/MRAS/RAF1/E2F4/RHEB/TSC1/BTRC/NBN/SIRT1/SQSTM1/ETS1/CDKN2B/MAP2K2/ATR/AKT3/PIK3R2/PPP3R1/NFATC1/RELA/MAPKAPK2	6.03277056930099
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	35/2452	56/9376	2.38988580750408	CCND2/GAS1/DISP1/CDON/SMO/SMURF2/CCND1/GLI2/SPOP/GLI3/SUFU/PRKACA/GPR161/BCL2/BOC/PRKACB/CSNK1G3/FBXW11/MEGF8/CUL3/SCUBE2/EVC2/SPOPL/EVC/BTRC/PTCH1/ARRB1/KIF7/CSNK1G2/MGRN1/GSK3B/IQCE/EFCAB7/CSNK1D/PTCH2	6.20772570768586
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	55/2452	110/9376	1.91190864600326	PITX2/EMP3/TGFBR2/BAMBI/TGFBR1/BMP5/DCN/GDF6/FBN1/ACVR2A/FMOD/FST/CREBBP/SMAD5/SMAD3/BMPR2/THBS1/SMAD6/TFRC/SMURF2/BMPR1A/LRRC32/NCOR1/SKI/TGFB3/ROCK1/SMAD4/PPP2CB/THSD4/BMP4/SKIL/SMAD7/ACVR1B/TGFB2/BMP6/LEFTY2/MYC/SMAD9/LTBP1/MAPK1/ACVR1/ZFYVE16/SIN3A/RPS6KB1/SP1/NEO1/LEMD3/E2F4/HAMP/TGIF2/CDKN2B/LEFTY1/ZFYVE9/PPP2R1A/ID4	5.72491271437162
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	66/2452	142/9376	1.77726719205937	UBB/SOCS1/UBE2I/KLHL9/SMURF2/UBE2E3/RCHY1/PIAS1/UBA7/UBE3A/STUB1/SOCS3/CDC34/CUL5/PML/PIAS2/RHOBTB1/KEAP1/BIRC2/FBXW11/UBE2L6/CUL7/CDC16/DDB2/UBE2R2/ANAPC16/TRIM32/SYVN1/CUL3/UBE2W/MAP3K1/ANAPC13/CDC27/WWP1/HERC2/UBE2B/UBE2Q1/BIRC7/PIAS3/CUL2/TRIP12/SIAH1/XIAP/BTRC/FZR1/ANAPC10/BIRC6/UBE2D2/UBA2/UBA6/NEDD4L/RHOBTB2/UBE2E1/DET1/NEDD4/FBXW8/MGRN1/UBE4B/UBE2J2/UBE4A/TRAF6/UBE2Z/UBR5/FANCL/CDC23/PIAS4	5.55375753420184
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	43/2452	80/9376	2.05530179445351	HGF/PDGFRA/IL6R/PDGFC/VEGFA/PDGFA/PRKCA/PIK3R1/PDGFRB/FOXO3/FGF2/FGFR2/EIF4EBP1/GAS6/AXL/IGF1R/SHC2/STAT3/AKT2/KRAS/PIK3CA/SOS1/BCL2/PTEN/MAPK1/NRG2/FGFR3/GAB1/SHC1/RPS6KB1/JAK2/BCL2L11/ARAF/RAF1/BCL2L1/SOS2/MAP2K2/AKT3/GSK3B/PLCG1/PIK3R2/SRC/NF1	5.64080327889328
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	58/2452	120/9376	1.84817835780315	ARHGDIG/CALM2/IRS1/ABL1/KIDINS220/PIK3R1/MAPK14/IRAK3/FOXO3/CAMK2D/SHC2/FRS2/MAP2K5/AKT2/KRAS/PDPK1/MAGED1/JUN/PIK3CA/CAMK2A/BDNF/SOS1/MAPK7/BCL2/MAPK1/SH2B1/SORT1/GAB1/RPS6KA3/SHC1/RAP1A/MAP3K3/MAP3K1/NFKB1/RAF1/PSEN1/CRK/MAPK10/SOS2/PSEN2/MAPK8/MAP2K7/NTF3/MAP2K2/IRAK4/AKT3/GSK3B/SH2B3/PLCG1/TRAF6/PIK3R2/IKBKB/NTRK2/RELA/MAPKAPK2/ATF4/ZNF274/PRKCD	5.56459393853573
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	44/2452	83/9376	2.02708386564201	CREBBP/PCGF5/CBX6/CBX4/USP7/SCML1/PHC3/PHF19/CBX8/PCGF2/FBRS/RYBP/PHF1/ASXL1/FOXK1/E2F6/RING1/SCMH1/USP16/MBD6/ASXL2/MAX/EZH1/PHC2/BCOR/MGA/YY1/CSNK2B/WDR5B/ASXL3/KDM2A/UBE2D2/OGT/DCAF7/BAP1/MBD5/CBX7/PCGF3/AUTS2/AEBP2/PHC1/FOXK2/YAF2/BMI1	5.59286486631966
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	87/2452	204/9376	1.63074560982631	HGF/WNT2/GPC3/VTN/SDC2/FZD2/TIMP3/LUM/DCN/COL1A2/COL1A1/IGF2/CD63/WNT2B/RRAS/WNT5B/TWIST1/VEGFA/ITPR1/PRKCA/PIK3R1/MAPK14/SMO/CD44/FGFR1/FZD1/THBS1/ANK2/FGF2/FZD7/CAMK2D/FN1/HSPB2/IGF1R/FRS2/ITGB5/ROCK2/CCND1/ROCK1/FAS/STAT3/PLAUR/AKT2/KRAS/PDPK1/PIK3CA/CAMK2A/PRKACA/CDKN1A/TGFB2/FLNA/SOS1/CAV2/FZD4/MYC/MMP2/MMP9/ITPR2/MAPK1/ARHGEF12/PLAU/PRKACB/TFAP4/GAB1/FZD6/RPS6KB1/PPP1R12B/ARAF/PLCE1/MRAS/PPP1R12A/RAF1/WNT11/MSN/PTCH1/WNT3/SOS2/MAP2K2/SLC9A1/AKT3/HIF1A/PLCG1/PIK3R2/DROSHA/SRC/SDC1/CASP3	5.42006679406401
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	129/2452	333/9376	1.48129859059712	HLA-B/SPP1/WNT2/CCND2/LAMA2/CREB3L1/HLA-A/TNFRSF1A/LAMB2/VTN/LAMC3/FZD2/COL6A1/COL6A2/COL1A2/COL1A1/ITGA1/WNT2B/WNT5B/CCND3/JAG1/NOTCH2/CREBBP/RBPJ/VEGFA/HLA-F/CDK6/RBL2/TSC2/PIK3R1/PDGFRB/HLA-C/FZD1/THBS1/FZD7/EIF4EBP1/FN1/ATP6V0D1/ATP6V1G1/CDK4/HES1/ITGA11/ITGB5/RFNG/CCND1/FAS/APC/PPP2CB/CHD4/HLA-E/AKT2/KRAS/COL4A5/UBE3A/LAMB1/IFNAR1/CREB1/PIK3CA/TNXB/ATM/PRKACA/LAMC1/LLGL2/CDKN1A/MAML2/TRADD/SOS1/FZD4/COL6A6/DLG3/NFX1/DVL3/TCF7L1/DVL2/PTEN/PRKCI/MAPK1/PPP2R5E/PRKACB/DLG1/TADA3/FZD6/CDKN1B/TLR3/ITGA4/ATP6V1C1/RPS6KB1/UBR4/CREB3/TUBG2/NFKB1/THBS3/RAF1/WNT11/ATP6AP1/PSEN1/RHEB/TCIRG1/COL9A2/ATP6V0A1/ATP6V1D/COL9A3/TSC1/PPP2R2D/WNT3/SOS2/MAP2K2/PPP2R3C/FADD/ATR/PPP2R5B/AKT3/GSK3B/LFNG/IKBKG/MAML1/PIK3R2/PPP2R1A/PPP2R5A/IKBKB/PARD6G/PARD3/RELA/HEYL/TICAM1/PTGER4/CASP3/ATP6V0B/ATP6V0A2	5.32166807115142
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	138/2452	362/9376	1.45769830468757	PRLR/HGF/SPP1/PDGFRA/CCND2/LAMA2/CREB3L1/LAMB2/VTN/LAMC3/FGF7/CSF1/COL6A1/COL6A2/COL1A2/COL1A1/IGF2/EPOR/ITGA1/CCND3/KITLG/IRS1/IL6R/PDGFC/OSMR/VEGFA/CDK6/PDGFA/PRKCA/VEGFC/RBL2/TSC2/PIK3R1/LPAR1/PDGFRB/GDNF/FGFR1/GNG11/FOXO3/THBS1/FGF2/FGFR2/EIF4EBP1/FN1/HSP90B1/IGF1R/PKN1/CDK4/IL4R/EFNA5/ITGA11/TEK/ITGB5/FGFR4/CCND1/ANGPT1/PPP2CB/AKT2/KRAS/COL4A5/PDPK1/STK11/LAMB1/IFNAR1/CREB1/PIK3CA/TNXB/LAMC1/BDNF/CDKN1A/ATF2/JAK3/SOS1/PKN2/COL6A6/MAGI2/MYC/DDIT4/BCL2/GNB4/PTEN/CHRM2/MAPK1/PPP2R5E/FGFR3/ATF6B/PHLPP2/CSH2/EFNA2/PRKAA1/CDKN1B/ITGA4/NOS3/NRTN/RPS6KB1/JAK2/G6PC3/GHR/CREB3/BCL2L11/NFKB1/THBS3/FLT3LG/RAF1/CSH1/RHEB/COL9A2/YWHAH/COL9A3/TSC1/PPP2R2D/BCL2L1/GNB3/SOS2/MLST8/VEGFB/GNB2/NTF3/MAP2K2/THEM4/PPP2R3C/PPP2R5B/AKT3/LPAR5/CD19/GSK3B/IKBKG/GNGT1/PIK3R2/PPP2R1A/PPP2R5A/IKBKB/NTRK2/RELA/PSPN/GNG12/LPAR6/ATF4	5.28496546503502
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	58/2452	122/9376	1.81788035193753	CREB3L1/IGFBP3/ADCY3/SOCS1/IRS1/CREBBP/GNAI1/ITPR1/PRKCA/PIK3R1/MAPK14/ADCY9/BCAR1/SHC2/PLCB1/STAT3/SOCS2/SSTR1/AKT2/KRAS/GNAI2/SOCS3/CREB1/PIK3CA/PRKACA/FOS/ATF2/SOS1/ITPR2/MAPK1/ADCY7/PRKACB/ATF6B/CSH2/JUNB/SHC1/MAP2K4/JAK2/ADCY6/GHR/CREB3/MAP3K1/GNA11/RAF1/CSH1/CRK/STAT5A/MAPK10/SOS2/MAPK8/MAP2K2/CACNA1C/AKT3/GSK3B/STAT5B/PLCG1/PIK3R2/ATF4	5.41093459584773
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	94/2452	227/9376	1.58343094911283	HLA-B/PDGFRA/CREB3L1/HLA-A/TNFRSF1A/CALM2/IL1R1/ADCY3/IL6R/GNAI1/VEGFA/HLA-F/ITPR1/CDK6/PRKCA/TSC2/PIK3R1/MAPK14/HLA-C/GNG11/EIF4EBP1/ADCY9/PTGER2/BCAR1/B2M/CDK4/NFATC4/PTGER1/ROCK2/CCND1/ROCK1/PLCB1/FAS/STAT3/HLA-E/AKT2/KRAS/GNAI2/CREB1/PIK3CA/PRKACA/NFATC3/CDKN1A/TRADD/ATF2/SOS1/NFATC2/GNA13/MYC/PPP3CB/RIPK1/IL10RB/ITPR2/GNB4/MAPK1/ARHGEF12/ADCY7/PRKACB/ATF6B/AKAP13/PPP3CC/ARHGEF11/RPS6KB1/SP1/ADCY6/CREB3/NFKB1/GNA11/TAPBPL/TAPBP/RAF1/RHEB/TSC1/CRK/GNB3/SOS2/GNB2/MAP2K2/FADD/AKT3/GSK3B/IKBKG/GNGT1/PIK3R2/PPP3R1/IKBKB/NFATC1/RELA/TRAF5/GNG12/ATF4/SRC/PTGER4/CASP3	5.29520672480907
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	77/2452	178/9376	1.65412321058709	WNT2/CCND2/RSPO2/RSPO3/SERPINF1/FRZB/BAMBI/MCC/FZD2/PRICKLE1/WNT2B/WNT5B/CCND3/RYK/CREBBP/PRKCA/SMAD3/FZD1/FZD7/CAMK2D/DAAM1/NFATC4/TBL1XR1/LZTS2/ROCK2/CCND1/PLCB1/APC/SMAD4/LRP5/SFRP2/ROR2/LRP6/JUN/CAMK2A/PRKACA/NFATC3/CBY1/NFATC2/FZD4/MYC/PPP3CB/DVL3/TCF7L1/DVL2/PRKACB/FBXW11/PPP3CC/VANGL1/FZD6/CSNK2A1/NKD2/ZNRF3/PRICKLE2/WNT11/PSEN1/MAP3K7/CSNK2B/SENP2/SIAH1/BTRC/WNT3/MAPK10/CSNK2A2/SIRT1/MAPK8/RSPO1/DKK1/TLE4/ROR1/DAAM2/GSK3B/MMP7/CTBP2/PPP3R1/NFATC1/CCAR2	5.24312485529488
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	78/2452	184/9376	1.62096602595929	SEMA6D/EPHA3/SLIT2/SLIT3/CFL2/RRAS/ENAH/WNT5B/EFNB2/PLXNB2/RYK/GNAI1/ABL1/PRKCA/PIK3R1/SMO/EPHA7/BMPR2/CAMK2D/FYN/NRP1/DPYSL2/PLXNA4/NFATC4/PLXNA2/EFNA5/ROCK2/TRPC1/ROCK1/UNC5B/LRIG2/KRAS/PDPK1/ROBO1/EFNB1/SEMA6B/GNAI2/PIK3CA/CAMK2A/NFATC3/NFATC2/RGS3/SEMA5A/PPP3CB/BOC/MAPK1/ARHGEF12/ROBO2/ROBO3/SEMA3C/PPP3CC/EFNA2/LIMK1/SEMA3A/MYL9/NEO1/ILK/RAF1/CDK5/PLXNA1/PTCH1/SEMA3G/UNC5C/NCK2/SSH1/EPHB3/EFNB3/GSK3B/PLCG1/PIK3R2/PPP3R1/PLXNB1/NCK1/PLXNA3/PARD6G/PARD3/SRC/SEMA4A	5.062197500674
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	40/2452	77/9376	1.98639859325014	TGFBR2/TGFBR1/ABL1/CDK6/PIK3R1/SMAD3/CDK4/SHC2/TGFB3/CCND1/GADD45B/SMAD4/POLK/AKT2/KRAS/PIK3CA/CDKN1A/TGFB2/SOS1/MYC/MAPK1/DDB2/SHC1/CDKN1B/GADD45G/ARAF/NFKB1/RAF1/CRK/STAT5A/BCL2L1/SOS2/MAP2K2/AKT3/STAT5B/IKBKG/PIK3R2/CTBP2/IKBKB/RELA	5.17186314706497
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	69/2452	158/9376	1.66989489334462	WNT2/TNFRSF1A/FZD2/WNT2B/WNT5B/IRS1/PRR5/PRKCA/DEPTOR/TSC2/PIK3R1/FZD1/FZD7/EIF4EBP1/RICTOR/IGF1R/ATP6V1G1/LPIN2/LRP5/AKT2/KRAS/PDPK1/STK11/LRP6/RRAGA/PIK3CA/ULK2/RRAGB/SOS1/FZD4/DDIT4/DVL3/DVL2/PTEN/MAPK1/FNIP1/RPS6KA3/PRKAA1/FZD6/ULK1/ATP6V1C1/LPIN1/RPS6KB1/SEC13/TELO2/RAF1/WDR24/WNT11/RHEB/LAMTOR3/ATP6V1D/TSC1/LAMTOR5/WNT3/SOS2/MLST8/RRAGC/FLCN/WDR59/AKT1S1/MAP2K2/CAB39/AKT3/GSK3B/NPRL3/PIK3R2/NPRL2/IKBKB/FNIP2	5.05340609992694
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	64/2452	144/9376	1.6994743520029	WNT2/IL6ST/LIFR/FZD2/WNT2B/ACVR2A/KLF4/WNT5B/ZFHX3/PCGF5/SMAD5/PIK3R1/MAPK14/FGFR1/SMAD3/BMPR2/FZD1/FGF2/FZD7/FGFR2/IGF1R/KAT6A/MEIS1/BMPR1A/FGFR4/STAT3/APC/SMAD4/AKT2/KRAS/BMP4/PIK3CA/SKIL/ACVR1B/JAK3/PCGF2/FZD4/LEFTY2/MYC/SMAD9/DVL3/DVL2/MAPK1/FGFR3/ACVR1/RIF1/FZD6/JAK2/RAF1/WNT11/REST/WNT3/SMARCAD1/MAP2K2/LEFTY1/TCF3/AKT3/HAND1/GSK3B/PCGF3/SETDB1/PIK3R2/ID4/BMI1	5.03352794753541
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	59/2452	130/9376	1.73542477098758	CREB3L1/TGFBR2/TGFBR1/COL1A2/COL1A1/COL3A1/ADCY3/GNAI1/VEGFA/PRKCA/VEGFC/PIK3R1/MAPK14/GNG11/ADCY9/EDNRB/SHC2/PLCB1/AKT2/KRAS/COL4A5/JUN/GNAI2/CREB1/PIK3CA/PRKACA/FOS/ATF2/SOS1/MMP2/MMP9/GNB4/MAPK1/ADCY7/PRKACB/ATF6B/SHC1/MAP2K4/NOS3/ADCY6/CREB3/NFKB1/RAF1/ARRB1/GNB3/MAPK10/SOS2/MAPK8/VEGFB/MAP2K7/GNB2/MAP2K2/AKT3/GNGT1/PIK3R2/RELA/GNG12/ATF4/SRC	5.02458649880104
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	37/2452	71/9376	1.9926935183696	PRLR/CCND2/CISH/SOCS1/GCK/PIK3R1/MAPK14/FOXO3/SHC2/CCND1/STAT3/SOCS2/AKT2/KRAS/SOCS5/SOCS3/PIK3CA/FOS/SOS1/MAPK1/SHC1/JAK2/NFKB1/RAF1/STAT5A/MAPK10/SOS2/MAPK8/MAP2K2/AKT3/GSK3B/STAT5B/SOCS6/PIK3R2/GALT/RELA/SRC	4.99635759058762
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	72/2452	170/9376	1.61949908837923	HGF/WNT2/TGFBR2/TGFBR1/FZD2/IGF2/WNT2B/WNT5B/GSTT1/CDK6/PRKCA/PIK3R1/SMAD3/FZD1/FZD7/SMARCD3/IGF1R/CDK4/GSTM3/SHC2/TGFB3/CCND1/GADD45B/APC/SMAD4/LRP5/POLK/AKT2/KRAS/LRP6/SMARCC2/PIK3CA/CDKN1A/TGFB2/SOS1/FZD4/MYC/DVL3/TCF7L1/DVL2/PTEN/MAPK1/KEAP1/ARID1B/GAB1/DDB2/FZD6/SHC1/RPS6KB1/NFE2L2/PHF10/SMARCE1/GADD45G/BRD7/ARAF/RAF1/WNT11/BCL2L1/WNT3/SOS2/ARID1A/SMARCD2/GSTM2/MGST2/PBRM1/MAP2K2/NQO1/AKT3/GSK3B/PLCG1/PIK3R2/ARID2	4.85061704523741
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	48/2452	101/9376	1.81725970313181	F3/VCAM1/TGFBR2/TGFBR1/COL1A2/COL1A1/COL3A1/VEGFA/PRKCA/VEGFC/PIK3R1/MAPK14/SMAD3/FN1/CDK4/TGFB3/CCND1/PLCB1/STAT3/SMAD4/AKT2/KRAS/COL4A5/PLCD3/JUN/PIK3CA/TGFB2/MMP2/BCL2/MAPK1/CDKN1B/NOS3/JAK2/SERPINE1/PLCE1/NFKB1/STAT5A/MAPK10/MAPK8/VEGFB/AKT3/STAT5B/PLCG1/PIK3R2/NFATC1/RELA/CASP3/PRKCD	4.9139547709663
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	43/2452	90/9376	1.82693492840312	CREB3L1/SESN3/ADCY3/IRS1/TSC2/PIK3R1/FOXO3/EIF4EBP1/ADCY9/IGF1R/APPL1/RB1CC1/AKT2/KRAS/STK11/CREB1/SESN1/PIK3CA/PRKACA/CAT/ATF2/ADCY7/PRKACB/ATF6B/PRKAA1/ULK1/RPS6KB1/ADCY6/CREB3/NFKB1/CAMKK2/RHEB/EHMT2/ADIPOR1/TSC1/SIRT1/AKT1S1/AKT3/EHMT1/PIK3R2/RELA/ATF4/PRKAB1	4.6907857029397
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	37/2452	75/9376	1.88641653072322	CCND2/SESN3/IGFBP3/CCND3/CDK6/TSC2/THBS1/CCNG2/CDK4/CCND1/GADD45B/FAS/CD82/RCHY1/SESN1/ATM/ZMAT3/CDKN1A/CHEK2/BCL2/PTEN/PPM1D/DDB2/GORAB/SERPINE1/BBC3/GADD45G/MDM4/SIAH1/BCL2L1/ATR/STEAP3/RRM2B/CCNG1/ZNF385A/APAF1/CASP3	4.58639016655241
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	95/2452	248/9376	1.46476872072831	TNFRSF1A/S100A10/AHNAK/RRAS/DYNLT3/PFN2/CASP1/MAPK14/WASL/HSP90B1/PKN1/ARL8A/ACTR10/RHOB/ROCK2/PLEKHM2/DYNC1LI2/SNX18/AKT2/DYNC2H1/RAB9A/ARF1/EXOC7/JUN/PIK3CA/TUBB2A/M6PR/FOS/IL18/FLNA/TRADD/LY96/MYC/RAB5A/NCKAP1/RIPK1/BCL2/TCF7L1/MAPK1/FYCO1/BIRC2/TAB2/KIF5B/KLC1/ACBD3/MAP2K4/PIK3C3/FHOD1/DCTN6/VPS16/MYL9/SNX9/ELMO1/TUBA3D/NFKB1/VPS11/DYNC2LI1/RAF1/CASP7/DYNC1H1/DCTN3/RAB7A/MAP3K7/GCC2/TUBA1A/KLC4/KPNA3/MAPK10/NOD1/CYTH3/MAPK8/SNX33/ELMO2/STX10/MAP2K7/CYTH1/DYNLRB1/CYTH2/MAP2K2/IRAK4/FADD/DYNLT1/AKT3/EXOC4/DCTN4/EXOC5/IKBKG/TRAF6/VPS39/IKBKB/RELA/DCTN1/VPS18/CASP3/PLEKHM1	4.41410092007688
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	71/2452	174/9376	1.56029326283025	MAN1A1/RRBP1/BAG2/MBTPS1/AMFR/SEC62/CRYAB/MAN1C1/CAPN2/SEC31A/DNAJC1/SEC63/HSP90B1/HERPUD1/TRAM1/UBXN4/EDEM3/ERLEC1/SEL1L/CKAP4/HSPA1A/UBXN6/SIL1/STUB1/MAN1B1/BCAP29/SEC24D/UGGT2/DERL2/SEC23A/OS9/BCL2/MBTPS2/SEC24B/ATF6B/DNAJB12/UBQLN2/NFE2L2/SEC13/SYVN1/RPN1/HSPA1B/KRTCAP2/DNAJB2/PPP1R15A/TXNDC5/ATF6/UBE2D2/SEC61A1/MAPK10/MAPK8/NPLOC4/YOD1/CRYAA/RNF5/STT3A/MAP2K7/UBQLN4/HSPA6/SAR1B/UBE4B/SEC61A2/UBE2J2/DDIT3/DERL1/EIF2AK3/MOGS/ATF4/TRAM1L1/HSPBP1/DAD1	4.43931795695931
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	15/2452	21/9376	2.73129806571895	DSEL/CSGALNACT1/DSE/CHST14/B3GAT3/CSGALNACT2/UST/CHSY3/CHPF2/CHST12/XYLT1/CHST3/B3GALT6/XYLT2/CHST15	4.72636150888582
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	57/2452	133/9376	1.63877883943137	CCND2/TGFBR2/TGFBR1/GABARAPL2/IRS1/KLF2/CREBBP/RBL2/PIK3R1/MAPK14/SMAD3/FOXO3/USP7/CCNG2/IGF1R/TGFB3/CCND1/GADD45B/STAT3/SMAD4/AKT2/KRAS/GABARAPL1/PDPK1/STK11/GABARAP/PIK3CA/ATM/CAT/CDKN1A/TGFB2/SOS1/PTEN/MAPK1/CDKN2D/PRKAA1/CDKN1B/G6PC3/SETD7/BCL2L11/GADD45G/ARAF/RAF1/HOMER3/FBXO32/MAPK10/SOS2/SIRT1/MAPK8/CDKN2B/MAP2K2/AKT3/PIK3R2/IKBKB/FBXO25/PRKAB1/PLK3	4.41506606449306
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	41/2452	87/9376	1.8020288387617	TGFBR2/TGFBR1/PIK3R1/SMAD3/TGFB3/CCND1/GADD45B/APC/SMAD4/APPL1/POLK/AKT2/KRAS/JUN/PIK3CA/FOS/CDKN1A/TGFB2/SOS1/MYC/BCL2/TCF7L1/MAPK1/DDB2/RALGDS/MSH6/RPS6KB1/BBC3/BCL2L11/GADD45G/ARAF/RAF1/MSH3/MAPK10/SOS2/MAPK8/MAP2K2/AKT3/GSK3B/PIK3R2/CASP3	4.47231588807513
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	67/2452	163/9376	1.57175312002722	CREB3L1/TGFBR2/TGFBR1/CREBBP/PRKCA/PIK3R1/MAPK14/SMAD3/NFATC4/TGFB3/FAS/STAT3/SMAD4/AKT2/KRAS/STAT6/JUN/IFNAR1/CREB1/PIK3CA/NFATC3/FOS/CDKN1A/TGFB2/ATF2/JAK3/SOS1/NFATC2/MYC/MMP9/BCL2/MAPK1/ATF6B/TAB2/DDB2/MAP2K4/TLR3/JAK2/CREB3/ARAF/MAP3K1/NFKB1/RAF1/ATP6AP1/IFIH1/MAP3K7/STAT5A/MAPK10/SOS2/MAPK8/MAP2K7/MAP2K2/IRAK4/FADD/AKT3/STAT5B/IKBKG/TRAF6/PIK3R2/IKBKB/NFATC1/APAF1/RELA/TICAM1/ATF4/SRC/CASP3	4.38196749163528
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	80/2452	203/9376	1.50692307074149	HGF/SPP1/PDGFRA/CCND2/LAMA2/LAMB2/VTN/LAMC3/COL6A1/COL6A2/COL1A2/COL1A1/EMP2/ITGA1/ARHGAP5/CCND3/PDGFC/CAPN2/VEGFA/PDGFA/PRKCA/VEGFC/PIK3R1/PDGFRB/THBS1/FYN/FN1/BCAR1/IGF1R/ARHGAP35/SHC2/ITGA11/ITGB5/ROCK2/CCND1/ROCK1/AKT2/COL4A5/PDPK1/EMP1/LAMB1/JUN/PIK3CA/TNXB/LAMC1/FLNA/SOS1/CAV2/COL6A6/BCL2/TLN2/PTEN/MAPK1/BIRC2/SHC1/ITGA4/RAP1A/MYL9/PPP1R12B/ILK/THBS3/PPP1R12A/RAF1/COL9A2/COL9A3/XIAP/CRK/MYLK/MAPK10/SOS2/MAPK8/MYLK3/VEGFB/DOCK1/AKT3/GSK3B/PIP5K1C/PIK3R2/PIP5K1A/SRC	4.34511945745211
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	54/2452	125/9376	1.65188907014682	TNFRSF1A/SGMS1/CTSD/GNAI1/CERS2/PRKCA/PIK3R1/MAPK14/DEGS1/FYN/ROCK2/ORMDL1/SMPD1/ROCK1/PLCB1/PPP2CB/AKT2/KRAS/ASAH1/PDPK1/GNAI2/PLD1/PIK3CA/CERS6/TRADD/GNA13/BCL2/PTEN/MAPK1/PPP2R5E/ORMDL3/KNG1/NOS3/NFKB1/SGMS2/RAF1/CERS4/S1PR5/SPTLC2/S1PR3/PPP2R2D/ADORA1/MAPK10/MAPK8/MAP2K2/SGPL1/PPP2R3C/PPP2R5B/AKT3/PIK3R2/PPP2R1A/PPP2R5A/SPTLC1/RELA	4.36618071507706
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	45/2452	99/9376	1.73809876909388	PDGFRA/PDGFC/PDGFA/PRKCA/TSC2/PIK3R1/PDGFRB/EIF4EBP1/CHPT1/AKT2/WASF2/KRAS/SLC22A3/SLC44A4/PDPK1/JUN/PLD1/PIK3CA/FOS/SOS1/MAPK1/RALGDS/RPS6KB1/SP1/RAF1/RHEB/SLC44A3/TSC1/MAPK10/SOS2/CHKB/PLA2G4A/MAPK8/DGKQ/DGKH/MAP2K2/AKT3/HIF1A/PIP5K1C/DGKE/PLCG1/PIK3R2/DGKD/CHKA/PIP5K1A	4.39334836628116
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	64/2452	155/9376	1.57886649476398	WNT2/CREB3L1/FZD2/HSD3B2/WNT2B/WNT5B/ADCY3/KMT2A/GNAI1/ITPR1/CDK6/AHR/FZD1/FZD7/CAMK2D/ADCY9/CDK4/ORAI1/CCND1/PLCB1/APC/MRAP/AIP/KCNK3/PBX1/GNAI2/CREB1/CAMK2A/PRKACA/CDKN1A/ATF2/FZD4/ITPR2/DVL3/TCF7L1/DVL2/MAPK1/ADCY7/PRKACB/ATF6B/USP8/FZD6/CDKN1B/RAP1A/SP1/ADCY6/CREB3/GNA11/WNT11/WDR5B/RASD1/WNT3/ASH2L/POMC/CDKN2B/ARMC5/MAP2K2/CACNA1C/CACNA1G/GSK3B/KMT2D/PDE8B/ATF4/RBBP5	4.32436747875285
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	89/2452	233/9376	1.46059973814842	DES/LAMA2/ATP1B1/FMNL2/FBLN2/COL5A2/FHL1/SGCE/SDC2/COL5A1/CSRP2/VCAN/TNNT1/COL6A1/TNNI3/FBLN1/COL6A2/DCN/COL1A2/VIM/COL1A1/COL3A1/SPTBN1/FBN1/NID1/ITGA1/TNNT3/ELN/SYNPO2/PDLIM4/BGN/PDLIM7/MYH10/SGCA/ATP1A1/SGCB/SUN1/THBS1/ANK2/TMEM43/SGCD/SPTAN1/FN1/SNTB1/DAAM1/ITGA11/SNTB2/ITGB5/SYNE1/LMOD1/AMPD2/SNTA1/ATP1A2/MYL3/COL4A5/FMNL1/DMD/CAPZA2/SYNE2/COL6A6/TLN2/PLEC/PDLIM3/LMNA/FHL3/COL11A1/TRIM63/COL5A3/ITGA4/MYOM1/MYL9/PDLIM5/THBS3/COL9A2/COL9A3/EMD/TNNT2/FLNC/NEB/DTNA/DAAM2/ACTN2/MYOM2/ENO3/FBN2/FMNL3/TMOD2/ENO2/SDC1	4.23666991564016
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	49/2452	112/9376	1.67292006525285	LAMA2/TNFRSF1A/LAMB2/LAMC3/HLA-DRA/SOCS1/GNAI1/IFNGR2/MAPK14/TGFB3/STAT3/HSPA1A/AKT2/PDPK1/HLA-DPA1/LAMB1/GNAI2/LAMC1/TGFB2/LY96/HLA-DPB1/IL10RB/HLA-DQA2/HLA-DMA/BCL2/MAPK1/BIRC2/TAB2/JAK2/HSPA1B/NFKB1/IFNGR1/BIRC7/MAP3K7/HLA-DMB/XIAP/BCL2L1/MAPK10/HLA-DRB1/MAPK8/HSPA6/IRAK4/AKT3/IKBKG/TRAF6/IKBKB/HLA-DQA1/RELA/CASP3	4.26324761756058
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	35/2452	73/9376	1.83333705781135	HGF/EML4/CDK6/PRKCA/PIK3R1/RARB/FOXO3/CDK4/CCND1/GADD45B/STAT3/POLK/AKT2/KRAS/PDPK1/PIK3CA/RXRB/CDKN1A/JAK3/SOS1/MAPK1/RASSF5/KIF5B/DDB2/GADD45G/ARAF/RAF1/STAT5A/SOS2/MAP2K2/AKT3/STAT5B/PLCG1/PIK3R2/RASSF1	4.25341693686839
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	42/2452	93/9376	1.72688522864811	MAF/HLA-DRA/JAG1/NOTCH2/RBPJ/IFNGR2/MAPK14/IL4R/STAT6/HLA-DPA1/JUN/NFATC3/FOS/MAML2/JAK3/HLA-DPB1/NFATC2/PPP3CB/HLA-DQA2/HLA-DMA/MAPK1/PPP3CC/JAK2/NFKB1/DLL4/IFNGR1/HLA-DMB/STAT5A/MAPK10/HLA-DRB1/MAPK8/CD4/STAT5B/IKBKG/LAT/MAML1/PLCG1/PPP3R1/IKBKB/HLA-DQA1/NFATC1/RELA	4.19208890041765
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	57/2452	138/9376	1.57940279452443	CALM2/SOCS1/PPP1R3C/IRS1/TRIP10/TSC2/GCK/PIK3R1/RHOQ/EIF4EBP1/PDE3B/SHC2/SOCS2/PRKAR1A/AKT2/KRAS/PDPK1/EXOC7/SOCS3/PIK3CA/PRKACA/SOS1/FLOT1/PRKCI/MAPK1/PRKACB/PTPN1/PRKAA1/SHC1/FBP1/SORBS1/PHKB/RPS6KB1/LIPE/G6PC3/ARAF/RAF1/INPP5A/RHEB/PRKAR1B/TSC1/CRK/MAPK10/SOS2/MAPK8/MAP2K2/PPP1R3E/ACACB/PRKAR2A/AKT3/GSK3B/PIK3R2/IKBKB/PPP1R3D/PRKAB1/SREBF1/INPPL1	4.08036009197727
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	71/2452	181/9376	1.49995042946112	MRC2/TNFRSF1A/CALM2/CTSD/HLA-DRA/CREBBP/IFNGR2/MAPK14/CAMK2D/ATP6V0D1/TGFB3/AKT2/CD74/HLA-DPA1/MALT1/CREB1/CAMK2A/VDR/TGFB2/IL18/TRADD/HLA-DPB1/RAB5A/PPP3CB/IL10RB/HLA-DQA2/HLA-DMA/BCL2/MAPK1/LSP1/ARHGEF12/PLA2R1/LAMP2/PPP3CC/PIK3C3/CTSS/JAK2/FCGR3A/CEBPB/KSR1/NFKB1/RFXAP/LAMP1/RAF1/ATP6AP1/IFNGR1/TCIRG1/RAB7A/ATP6V0A1/HLA-DMB/NFYC/RFXANK/MAPK10/HLA-DRB1/MAPK8/RFX5/IRAK4/FADD/EEA1/AKT3/TRAF6/PPP3R1/HLA-DQA1/APAF1/RELA/SRC/ITGB2/CASP3/ATP6V0B/PLK3/ATP6V0A2	4.04164075241191
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	63/2452	157/9376	1.53439802163319	WNT2/CCND2/TGFBR2/TGFBR1/YAP1/FZD2/BMP5/GDF6/WNT2B/WNT5B/CCND3/SNAI2/SMAD3/BMPR2/FZD1/FZD7/BMPR1A/TGFB3/CCND1/GLI2/APC/SMAD4/PPP2CB/BMP4/LATS2/SMAD7/LLGL2/TGFB2/FZD4/BMP6/DLG3/MYC/DVL3/TCF7L1/DVL2/PRKCI/WTIP/DLG4/BIRC2/AJUBA/DLG1/FBXW11/FZD6/NKD2/SERPINE1/BBC3/NF2/WNT11/YWHAH/LATS1/BTRC/PPP2R2D/WNT3/GSK3B/SAV1/PPP2R1A/PARD6G/PARD3/CSNK1D/RASSF1/ITGB2/TEAD2/TP53BP2	4.01827913164177
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	47/2452	109/9376	1.64880195159914	IL6ST/TGFBR2/TGFBR1/IL1R1/HLA-DRA/IL6R/IFNGR2/AHR/MAPK14/SMAD3/IL4R/STAT3/SMAD4/RARA/STAT6/HLA-DPA1/JUN/RXRB/NFATC3/FOS/JAK3/HLA-DPB1/NFATC2/PPP3CB/HLA-DQA2/HLA-DMA/MAPK1/PPP3CC/JAK2/NFKB1/IFNGR1/HLA-DMB/STAT5A/MAPK10/HLA-DRB1/MAPK8/CD4/STAT5B/HIF1A/IKBKG/LAT/PLCG1/PPP3R1/IKBKB/HLA-DQA1/NFATC1/RELA	4.05436791686455
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	39/2452	86/9376	1.73405667893319	ABL1/PRKCA/PIK3R1/EIF4EBP1/CAMK2D/SHC2/AKT2/KRAS/JUN/PIK3CA/CAMK2A/CDKN1A/SOS1/MYC/MAPK1/NRG2/GAB1/SHC1/MAP2K4/CDKN1B/RPS6KB1/ARAF/RAF1/CRK/STAT5A/MAPK10/SOS2/BTC/NCK2/MAPK8/MAP2K7/MAP2K2/AKT3/GSK3B/STAT5B/PLCG1/PIK3R2/NCK1/SRC	4.06947424886869
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	56/2452	137/9376	1.56302020695157	TNFRSF1A/CTSC/CTSD/CTSO/CAPN2/ITPR1/PIK3R1/SPTAN1/GADD45B/FAS/AKT2/KRAS/CTSF/PDPK1/JUN/NOL3/PIK3CA/ATM/FOS/TRADD/RIPK1/ITPR2/BCL2/MAPK1/BIRC2/LMNA/PTPN13/CTSS/CTSZ/BBC3/BCL2L11/GADD45G/TUBA3D/NFKB1/RAF1/CASP7/HTRA2/PARP3/XIAP/TUBA1A/BCL2L1/MAPK10/MAPK8/MAP2K2/FADD/AKT3/DDIT3/EIF2AK3/IKBKG/PIK3R2/IKBKB/APAF1/RELA/ATF4/CTSB/CASP3	3.95038227202142
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	50/2452	119/9376	1.60664592101115	VCAM1/CREB3L1/TNFRSF1A/CSF1/JAG1/RHBDF1/VEGFC/PIK3R1/MAPK14/FAS/AKT2/JUN/CYLD/SOCS3/CREB1/PIK3CA/FOS/RHBDF2/TRADD/ATF2/RIPK1/MMP9/MAPK1/BCL3/ATF6B/BIRC2/TAB2/JUNB/MAP2K4/CEBPB/IL18R1/CREB3/NFKB1/CASP7/RPS6KA4/MAP3K7/XIAP/MAPK10/MAPK8/BAG4/MAP2K7/FADD/AKT3/IKBKG/PIK3R2/IKBKB/RELA/TRAF5/ATF4/CASP3	3.96315421646226
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	51/2452	122/9376	1.59848099911748	SLC16A10/DIO3/ATP1B1/GATA4/NOTCH2/CREBBP/THRA/PRKCA/MED13L/TSC2/PIK3R1/ATP1A1/PFKM/NCOR1/CCND1/PLCB1/AKT2/ATP1A2/KRAS/BMP4/PDPK1/MED13/PLCD3/PIK3CA/RXRB/MED30/NCOA1/PRKACA/MYC/MAPK1/PRKACB/SIN3A/NCOA2/PLCE1/HDAC3/KAT2B/RAF1/RHEB/MED4/MED14/MED27/MED1/MAP2K2/SLC9A1/AKT3/GSK3B/HIF1A/PLCG1/PIK3R2/MED16/SRC	3.95943188439579
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	75/2452	196/9376	1.46319539234944	HLA-B/IL6ST/HLA-A/TNFRSF1A/CALM2/UBB/CREBBP/VEGFA/HLA-F/ITPR1/CDK6/PIK3R1/MAPK14/HLA-C/GNG11/FGF2/LYN/CDK4/NFATC4/CCND1/FAS/STAT3/HLA-E/AKT2/KRAS/JUN/IFNAR1/CREB1/PIK3CA/NFATC3/FOS/CDKN1A/TRADD/NFATC2/MYC/PPP3CB/ITPR2/GNB4/TCF7L1/MAPK1/PPP3CC/MAP2K4/PIK3C3/TLR3/JAK2/NFKB1/RAF1/ATG14/IFNGR1/GNB3/MAPK10/MAPK8/MAP1LC3B/MAP2K7/GNB2/MAP2K2/FADD/AKT3/GSK3B/HIF1A/ZFP36/IKBKG/GNGT1/PLCG1/PIK3R2/PPP3R1/MICA/IKBKB/NFATC1/RELA/TICAM1/MAPKAPK2/GNG12/SRC/CASP3	3.89976347321298
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	34/2452	73/9376	1.78095599901674	BST2/SERINC3/MAP1B/CREBBP/MLLT3/FEZ1/MDFIC/MAP1A/MAP1S/AFF4/CCNT2/APOBEC3C/SERINC5/ELL2/NELFE/CPSF7/VPS4A/PIN1/KAT2B/CDK9/BICD2/SAMHD1/PDCD6IP/NELFB/RANBP2/CD4/CHMP6/APOBEC3G/PSIP1/APOBEC3F/VPS4B/SUPT4H1/HGS/NUP153	3.98605995260893
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	25/2452	49/9376	1.95092718979925	GALNT1/GXYLT2/GALNT10/POFUT2/RFNG/GALNT12/GALNT11/COLGALT1/PLOD3/XXYLT1/GALNT7/ST6GAL2/B4GALT2/C1GALT1/B4GALT3/ST3GAL3/POMT2/OGT/POFUT1/FUT10/GALNT18/LFNG/C1GALT1C1/FUT11/POGLUT1	3.97138195807942
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	77/2452	205/9376	1.43626308041221	HLA-B/CCND2/HLA-A/VIM/CCND3/HLA-DRA/RBPJ/HLA-F/CDK6/PIK3R1/MAPK14/HLA-C/CD44/USP7/LYN/B2M/CDK4/HES1/CCND1/GADD45B/FAS/STAT3/CIR1/POLK/HLA-E/AKT2/HLA-DPA1/JUN/IFNAR1/PIK3CA/SAP30L/CDKN1A/TRADD/JAK3/HLA-DPB1/PSMC2/MYC/RIPK1/HLA-DQA2/HLA-DMA/BCL2/TAB2/DDB2/MAP2K4/CDKN1B/SIN3A/SAP30/BCL2L11/GADD45G/NFKB1/TAPBPL/TAPBP/CD58/MAP3K7/HLA-DMB/MAPK10/HLA-DRB1/MAPK8/MAP2K7/IRAK4/FADD/NEDD4/NFKB2/AKT3/CD19/NCOR2/IKBKG/TRAF6/PIK3R2/PSMD6/IKBKB/HLA-DQA1/APAF1/RELA/TRAF5/SNW1/CASP3	3.75823892971938
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	35/2452	77/9376	1.73809876909388	TGFBR2/TGFBR1/VEGFA/CDK6/PIK3R1/SMAD3/CDK4/TGFB3/CCND1/GADD45B/STAT3/SMAD4/POLK/AKT2/KRAS/PLD1/PIK3CA/CDKN1A/TGFB2/MAPK1/DDB2/RALGDS/RPS6KB1/GADD45G/ARAF/NFKB1/RAF1/BCL2L1/MAPK10/MAPK8/AKT3/IKBKG/PIK3R2/IKBKB/RELA	3.86998303616049
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	56/2452	140/9376	1.52952691680261	SPP1/TGFBR1/CALM2/RRAS/ADCY3/JAG1/KLF2/GNAI1/ITPR1/PLAT/SMAD3/GNG11/ADCY9/MEF2A/PDE3B/CCND1/PLCB1/SMAD4/AKT2/MYL3/KRAS/GNAI2/MEF2D/PRKACA/GNA13/ITPR2/GNB4/MAPK1/ADCY7/PRKACB/PRKAA1/SLC8A1/PIK3C3/NOS3/RPS6KB1/LIPE/RYR2/ADCY6/SERPINE1/MRAS/RAF1/PIK3R4/MYLK/HDAC4/GNB3/MAP1LC3B/MYLK3/GNB2/MAP2K2/SLC9A1/AKT3/GNGT1/NRF1/RYR1/GNG12/PRKAB1	3.75644849191621
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	50/2452	122/9376	1.5671382344289	CD36/CREB3L1/IRS1/TSC2/PIK3R1/FOXO3/EIF4EBP1/IGF1R/PFKM/CCND1/PPP2CB/AKT2/PDPK1/STK11/SCD5/CREB1/PIK3CA/EEF2K/RAB14/CPT1A/PPP2R5E/PRKAA1/ULK1/FBP1/RAB2A/RPS6KB1/LIPE/G6PC3/CREB3/MLYCD/CAMKK2/RHEB/MAP3K7/ADIPOR1/TSC1/PPP2R2D/RAB11B/SIRT1/AKT1S1/ACACB/CAB39/PPP2R3C/PPP2R5B/AKT3/TBC1D1/PIK3R2/PPP2R1A/PPP2R5A/PRKAB1/SREBF1	3.75207435418837
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	39/2452	90/9376	1.65698749320283	EML4/IFNGR2/PIK3R1/MAPK14/STAT3/AKT2/KRAS/JUN/PIK3CA/NFATC3/FOS/NFATC2/PPP3CB/PTEN/MAPK1/PPP3CC/CSNK2A1/RPS6KB1/JAK2/MAP3K3/NFKB1/RAF1/IFNGR1/CSNK2B/CSNK2A2/MAP2K2/AKT3/CD4/HIF1A/IKBKG/LAT/PLCG1/TRAF6/PIK3R2/PPP3R1/IKBKB/NFATC1/RELA/TICAM1	3.72675942722266
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	40/2452	93/9376	1.64465259871248	LAMA2/LAMB2/LAMC3/CDK6/PIK3R1/RARB/FN1/CDK4/CCND1/GADD45B/POLK/AKT2/COL4A5/LAMB1/PIK3CA/RXRB/LAMC1/CDKN1A/MYC/BCL2/PTEN/BIRC2/DDB2/CDKN1B/GADD45G/MAX/NFKB1/BIRC7/XIAP/BCL2L1/CDKN2B/AKT3/IKBKG/TRAF6/PIK3R2/IKBKB/APAF1/RELA/TRAF5/CASP3	3.71783728321748
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	79/2452	214/9376	1.4115961031239	HLA-B/HLA-A/BST2/TNFRSF1A/CFL2/CALM2/GNAI1/HLA-F/ITPR1/PRKCA/PIK3R1/MAPK14/HLA-C/GNG11/B2M/NFATC4/FAS/HLA-E/AKT2/KRAS/JUN/GNAI2/PIK3CA/ATM/NFATC3/FOS/TRADD/NFATC2/CUL5/PPP3CB/RIPK1/APOBEC3C/ITPR2/BCL2/GNB4/MAPK1/TAB2/FBXW11/PPP3CC/RPS6KB1/LIMK1/NFKB1/GNA11/TAPBPL/TAPBP/RAF1/MAP3K7/BTRC/CRK/BCL2L1/GNB3/MAPK10/AP1G1/MAPK8/SAMHD1/MAP2K7/GNB2/MAP2K2/IRAK4/FADD/AP1S2/ATR/AKT3/CD4/APOBEC3G/IKBKG/GNGT1/PLCG1/TRAF6/PIK3R2/APOBEC3F/PPP3R1/IKBKB/NFATC1/RELA/TRAF5/GNG12/AP1M1/CASP3	3.62451865039129
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	42/2452	99/9376	1.62222551782095	ADCY3/JAG1/NOTCH2/PIK3R1/MAPK14/ADCY9/IGF1R/CDK4/SHC2/NCOR1/CCND1/AKT2/KRAS/JUN/PIK3CA/PRKACA/FOS/CDKN1A/SOS1/MMP2/MMP9/BCL2/MAPK1/ADCY7/PRKACB/SHC1/CDKN1B/RPS6KB1/SP1/ADCY6/ARAF/RAF1/DLL4/MAPK10/SOS2/MED1/MAPK8/GPER1/MAP2K2/AKT3/PIK3R2/SRC	3.70364181142461
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	47/2452	115/9376	1.56277750195049	CREB3L1/ADCY3/GNAI1/ITPR1/PRKCA/FGFR1/PTH1R/ADCY9/MEF2A/CYP24A1/MMP16/WNK1/PLCB1/LRP5/LRP6/PDE4A/GNAI2/PLD1/CREB1/RXRB/VDR/MEF2D/PRKACA/FOS/CDKN1A/ATF2/GNA13/ITPR2/BCL2/JUND/MAPK1/ADCY7/PRKACB/ATF6B/AKAP13/ARHGEF11/SP1/ADCY6/CREB3/ARAF/GNA11/STK39/RAF1/ARRB1/PDE4B/WNK3/ATF4	3.6134666182857
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	54/2452	138/9376	1.49627633165473	PIK3R1/CASP1/MAPK14/WASL/FN1/BCAR1/PKN1/ROCK2/ROCK1/AKT2/WASF2/JUN/PIK3CA/NFATC3/FOS/IL18/WIPF1/NFATC2/PKN2/MAPK1/ARHGEF12/TAB2/RPS6KA3/MAP2K4/ITGA4/LIMK1/ELMO1/NFKB1/GIT2/MAP3K7/CRK/MAPK10/MAPK8/ELMO2/DOCK1/MAP2K7/MAP2K2/IRAK4/WIPF2/AKT3/CD4/GSK3B/IKBKG/PIP5K1C/LAT/PLCG1/TRAF6/PIK3R2/IKBKB/NFATC1/PIP5K1A/RELA/TICAM1/SRC	3.49495404132268
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	60/2452	157/9376	1.46133144917447	CD36/EPOR/BSG/PROS1/LRP1/CASP1/MAPK14/GULP1/THBS1/ABCA1/CAMK2D/GAS6/PLA2G15/PTGER2/TMEM30A/AXL/BCAR1/NFATC4/ADAM10/ITGB5/DUSP7/PBX1/CREB1/CAMK2A/NFATC3/ATP11B/RAB14/NFATC2/RAB5A/CPT1A/MAPK1/ANO6/VPS16/JAK2/CEBPB/ELMO1/TYRO3/VPS11/DNMT3A/CASP7/SIRPA/DUSP8/RAB7A/TGFBRAP1/XKR8/ADAM9/VPS8/CRK/LIPA/SIRT1/DOCK1/MAP2K2/HIF1A/CD47/VPS39/NFATC1/MAPKAPK2/PTGER4/VPS18/CASP3	3.46887237591653
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	59/2452	154/9376	1.46496896252198	CALM2/ADCY3/GNAI1/ITPR1/PRKCA/CAMK2D/ADCY9/CACNA2D1/GUCY1A2/NFATC4/ROCK2/MAP2K5/CCND1/ROCK1/PLCB1/KRAS/JUN/GNAI2/CAMK2A/PRKACA/EEF2K/NFATC3/FOS/CDKN1A/NFATC2/NPR2/MAPK7/PPP3CB/ITPR2/KCNJ12/MAPK1/ADCY7/PRKACB/CACNB4/PPP3CC/PRKAA1/NOS3/RYR2/ADCY6/MYL9/PPP1R12B/PPP1R12A/RAF1/CAMKK2/CACNB2/MYLK/KCNJ5/PLA2G4A/MYLK3/MAP2K2/CACNA1C/PPP3R1/CACNB1/CACNB3/NFATC1/RYR1/KCNJ6/SRC/PRKAB1	3.46209600598996
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	47/2452	117/9376	1.53606335661801	SMARCA1/BPTF/RSF1/SMARCD3/BAZ2B/BCL7C/CHD4/SMARCC2/EPC1/DPF2/MTA1/GATAD2B/MEAF6/ARID1B/INO80D/MRGBP/EPC2/CHRAC1/PHF10/SMARCE1/BAZ1B/BRD7/CHD3/YY1/BAZ2A/KAT5/TRRAP/ING3/MCRS1/ARID1A/BCL7A/SMARCD2/PBRM1/MORF4L1/MTA3/INO80B/INO80/ZNHIT1/SRCAP/BRD8/ARID2/BCL7B/SS18L1/ACTR8/EP400/DMAP1/PHF6	3.47211700463862
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	54/2452	139/9376	1.48551175372915	CREB3L1/CALM2/CTSD/ADCY3/GNAI1/ITPR1/PIK3R1/ADCY9/HSP90B1/SHC2/PLCB1/RARA/HSPA1A/AKT2/KRAS/JUN/GNAI2/CREB1/PIK3CA/NCOA1/PRKACA/FOS/ATF2/SOS1/EBAG9/GABBR1/MMP2/MMP9/ITPR2/BCL2/MAPK1/ADCY7/PRKACB/ATF6B/SHC1/NOS3/NCOA2/SP1/ADCY6/CREB3/HSPA1B/RAF1/SOS2/KCNJ5/POMC/GPER1/HSPA6/MAP2K2/AKT3/PIK3R2/KCNJ6/ATF4/SRC/PRKCD	3.43169765560667
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	12/2452	19/9376	2.41504250021465	NAGLU/HYAL2/HEXA/GUSB/GALNS/HEXB/ARSB/GLB1/HGSNAT/SGSH/GNS/IDUA	3.67405210534303
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	31/2452	70/9376	1.69340480074575	HLA-B/LAMA2/HLA-A/SGCE/HLA-DRA/ABL1/SGCA/HLA-F/SGCB/HLA-C/SGCD/FYN/SNTB1/SNTB2/CCND1/HLA-E/SNTA1/HLA-DPA1/DMD/EIF4G3/HLA-DPB1/HLA-DQA2/HLA-DMA/HLA-DMB/HLA-DRB1/EIF4G2/DTNA/EIF4G1/HLA-DQA1/ITGB2/CASP3	3.46514714681447
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	43/2452	106/9376	1.55117116562529	PDGFRA/CREB3L1/CREBBP/PDGFC/PDGFA/PIK3R1/PDGFRB/PLAT/FGFR1/FGFR2/HSP90B1/IGF1R/CCND1/AKT2/KRAS/PDPK1/CREB1/PIK3CA/CDKN1A/SOS1/MMP9/BCL2/TCF7L1/PTEN/MAPK1/PLAU/CDKN1B/CREB3/ZEB1/ARAF/NFKB1/RAF1/ERG/SOS2/MAP2K2/AKT3/GSK3B/IKBKG/PIK3R2/IKBKB/RELA/ATF4/SLC46A1	3.39599386164968
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	28/2452	62/9376	1.72688522864811	JAG1/NOTCH2/CREBBP/RBPJ/HES1/ATXN1/RFNG/CIR1/DTX3/MAML2/NUMB/APH1A/DVL3/DVL2/ATXN1L/NUMBL/KAT2B/DLL4/PSEN1/PSEN2/NCSTN/TLE4/LFNG/NCOR2/MAML1/CTBP2/HEYL/SNW1	3.4171253709916
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	17/2452	32/9376	2.03140293637847	TNFRSF1A/BCL2/BIRC2/BBC3/BCL2L11/CASP7/BIRC7/HTRA2/XIAP/BIRC6/BCL2L1/MAPK10/MAPK8/BOK/FADD/APAF1/CASP3	3.47779740665141
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	56/2452	148/9376	1.44684978616463	WNT2/FZD2/FGF7/WNT2B/WNT5B/JAG1/NOTCH2/CDK6/PIK3R1/FGFR1/FZD1/FGF2/FZD7/IGF1R/CDK4/HES1/SHC2/CCND1/GADD45B/APC/LRP5/POLK/AKT2/KRAS/LRP6/JUN/PIK3CA/NCOA1/FOS/CDKN1A/SOS1/FZD4/MYC/DVL3/TCF7L1/DVL2/PTEN/MAPK1/DDB2/FZD6/SHC1/RPS6KB1/SP1/GADD45G/ARAF/RAF1/WNT11/DLL4/WNT3/SOS2/MAP2K2/NFKB2/AKT3/GSK3B/PIK3R2/HEYL	3.26066334043344
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	54/2452	142/9376	1.45412770259403	VCAM1/TNFRSF1A/SDC2/CALM2/ACVR2A/IL1R1/GSTT1/KLF2/VEGFA/PDGFA/PIK3R1/MAPK14/PLAT/BMPR2/MEF2A/HSP90B1/GSTM3/BMPR1A/MAP2K5/AKT2/BMP4/ARHGEF2/JUN/PIK3CA/FOS/CAV2/MAPK7/MMP2/MMP9/BCL2/KEAP1/ACVR1/PRKAA1/MAP2K4/NOS3/NFE2L2/NFKB1/MAP3K7/MAPK10/SQSTM1/MAPK8/MAP2K7/GSTM2/MGST2/NQO1/AKT3/IKBKG/PIK3R2/IKBKB/RELA/SUMO1/SRC/SDC1/PIAS4	3.24484961611338
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	28/2452	63/9376	1.6994743520029	PLOD2/KMT2E/PRDM6/KMT2A/ALDH9A1/ASH1L/SETD2/PHYKPL/NSD1/KMT2B/ALDH3A2/COLGALT1/PLOD3/SETD7/EZH1/SETD1A/EHMT2/KMT2C/SMYD3/DLD/SETD1B/TMLHE/EHMT1/KMT2D/SETDB1/DLST/PRDM2/SETMAR	3.31485555985057
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	28/2452	63/9376	1.6994743520029	WNT2/FZD2/WNT2B/WNT5B/SMO/FZD1/FZD7/GADD45B/GLI2/APC/POLK/GLI3/BMP4/SUFU/CDKN1A/FZD4/DVL3/TCF7L1/DVL2/DDB2/FZD6/GADD45G/WNT11/PTCH1/WNT3/KIF7/GSK3B/PTCH2	3.31485555985057
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	83/2452	238/9376	1.33351611443925	HGF/PDGFRA/FGF7/CSF1/IGF2/CALM2/RRAS/KITLG/PDGFC/ABL1/VEGFA/PDGFA/PRKCA/VEGFC/PIK3R1/PDGFRB/FGFR1/GNG11/FGF2/FGFR2/IGF1R/SHC2/EFNA5/TEK/FGFR4/ANGPT1/AKT2/KRAS/PLD1/RGL1/PIK3CA/PRKACA/BDNF/SOS1/RAB5A/RASA3/GNB4/MAPK1/RASSF5/PRKACB/FGFR3/EFNA2/GAB1/SHC1/RALGDS/RAP1A/KSR1/SHOC2/PLCE1/NFKB1/RALGAPA1/MRAS/SYNGAP1/FLT3LG/RAF1/RASAL2/BCL2L1/GNB3/MAPK10/SOS2/PLA2G4A/RALGAPB/MAPK8/ETS1/VEGFB/GNB2/NTF3/MAP2K2/RALGAPA2/AKT3/IKBKG/GNGT1/LAT/PLCG1/PIK3R2/IKBKB/NTRK2/RELA/RIN1/RASSF1/GNG12/RASA4/NF1	3.10132346921585
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	17/2452	33/9376	1.96984527163973	VAMP5/STX2/VAMP2/STX4/STX18/GOSR1/STX11/STX5/STX1A/VAMP4/VAMP7/STX17/USE1/BET1/STX16/BET1L/VAMP1	3.32111251990874
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	21/2452	44/9376	1.82500370754857	CREB3L1/ARHGDIG/ADCY3/AQP3/ADCY9/VAMP2/STX4/DYNC1LI2/DYNC2H1/CREB1/PRKACA/RAB5A/PRKACB/DCTN6/ADCY6/CREB3/DYNC2LI1/DYNC1H1/RAB11B/DCTN4/DCTN1	3.26409067657202
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	30/2452	70/9376	1.63877883943137	HGF/CREBBP/VEGFA/PIK3R1/TGFB3/AKT2/KRAS/EGLN2/JUN/PIK3CA/CDKN1A/TGFB2/SOS1/MAPK1/PRCC/GAB1/EPAS1/RAP1A/ARAF/RAF1/TFE3/CUL2/CRK/SOS2/ETS1/FLCN/MAP2K2/AKT3/HIF1A/PIK3R2	3.19216519776113
Human Diseases	Cancer: specific types	hsa05214	Glioma	32/2452	76/9376	1.61002833347643	PDGFRA/CALM2/CDK6/PDGFA/PRKCA/PIK3R1/PDGFRB/CAMK2D/IGF1R/CDK4/SHC2/CCND1/GADD45B/POLK/AKT2/KRAS/PIK3CA/CAMK2A/CDKN1A/SOS1/PTEN/MAPK1/DDB2/SHC1/GADD45G/ARAF/RAF1/SOS2/MAP2K2/AKT3/PLCG1/PIK3R2	3.17747886244703
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	39/2452	98/9376	1.52172320804341	CALM2/ITPR1/PRKCA/PIK3R1/PLCB1/CDIPT/PLCD3/PIK3CA/SACM1L/INPP1/ITPR2/PTEN/IP6K1/PIKFYVE/PIK3C3/MTMR2/PI4KB/IP6K3/PLCE1/PIP4K2A/INPP5A/ITPKA/MTMR6/ITPKC/MTMR3/IP6K2/DGKQ/DGKH/PIP4K2B/IPMK/OCRL/PIP5K1C/DGKE/PLCG1/PIK3R2/DGKD/PIP5K1A/INPPL1/INPP5E	3.0895366492141
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	26/2452	59/9376	1.68507202698593	PIK3R1/FOXO3/CCND1/GADD45B/APC/POLK/AKT2/KRAS/PDPK1/PIK3CA/CDKN1A/SOS1/MYC/TCF7L1/PTEN/MAPK1/DDB2/GADD45G/ARAF/ILK/RAF1/SOS2/MAP2K2/AKT3/GSK3B/PIK3R2	3.14117067435
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	36/2452	89/9376	1.54671261249702	GJA1/PDGFRA/ADCY3/PDGFC/PRKG1/GNAI1/ITPR1/PDGFA/PRKCA/LPAR1/PDGFRB/ADCY9/GUCY1A2/MAP2K5/PLCB1/TJP1/KRAS/GNAI2/TUBB2A/PRKACA/SOS1/MAPK7/ITPR2/MAP3K2/MAPK1/ADCY7/PRKACB/ADCY6/TUBA3D/GNA11/RAF1/TUBA1A/SOS2/MAP2K2/CSNK1D/SRC	3.08378232651262
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	55/2452	149/9376	1.41147618161315	PDGFRA/AGPAT4/RRAS/ADCY3/KITLG/PDGFC/PDGFA/PRKCA/TSC2/PIK3R1/LPAR1/PDGFRB/ADCY9/FYN/AGPAT2/PTGFR/SHC2/PLCB1/AKT2/KRAS/ARF1/PLD1/PIK3CA/AGPAT3/SOS1/GNA13/MAPK1/ADCY7/DNM1/GAB1/SHC1/RALGDS/ADCY6/MRAS/RAF1/RHEB/TSC1/AGPAT1/SOS2/PLA2G4A/CYTH3/DGKQ/DGKH/CYTH1/CYTH2/MAP2K2/AKT3/LPAR5/PIP5K1C/DGKE/PLCG1/PIK3R2/DGKD/PIP5K1A/LPAR6	3.0128320071275
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	60/2452	166/9376	1.38210263566501	CREB3L1/ATP1B1/ATP2B1/CALM2/GATA4/ADCY3/IRS1/ADRB3/PRKG1/GNAI1/ITPR1/PDE3A/ATP1A1/GTF2I/ADCY9/MEF2A/PDE3B/GUCY1A2/NFATC4/EDNRB/ROCK2/ROCK1/PLCB1/AKT2/ATP1A2/GNAI2/CREB1/MEF2D/NFATC3/ADRA2A/ATF2/NFATC2/NPR2/GNA13/PPP3CB/ITPR2/MAPK1/ADCY7/ATF6B/PPP3CC/SLC8A1/KNG1/NOS3/KCNMA1/ADCY6/MYL9/CREB3/GNA11/PPP1R12A/RAF1/MYLK/ATP2B4/ADORA1/MYLK3/MAP2K2/CACNA1C/AKT3/PPP3R1/NFATC1/ATF4	2.95577658082354
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	37/2452	93/9376	1.52130365380905	CALM2/ADCY3/ITPR1/PRKCA/MAPK14/CAMK2D/ADCY9/PLCB1/KRAS/JUN/PLD1/CAMK2A/PRKACA/SOS1/MAPK7/MMP2/ITPR2/MAP3K2/MAPK1/ADCY7/PRKACB/MAP2K4/MAP3K3/ADCY6/MAP3K1/GNA11/RAF1/MAPK10/SOS2/PLA2G4A/MAPK8/MAP2K7/MAP2K2/CACNA1C/ATF4/SRC/PRKCD	3.00645985741722
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	55/2452	150/9376	1.40206634040239	HGF/WNT2/TGFBR2/TGFBR1/FZD2/FGF7/WNT2B/WNT5B/PIK3R1/RARB/SMAD3/FZD1/FGF2/FZD7/FGFR2/SHC2/TGFB3/CCND1/GADD45B/APC/SMAD4/LRP5/POLK/AKT2/KRAS/LRP6/PIK3CA/RXRB/CDKN1A/TGFB2/SOS1/FZD4/MYC/BCL2/DVL3/TCF7L1/DVL2/MAPK1/GAB1/DDB2/FZD6/SHC1/CDKN1B/RPS6KB1/GADD45G/ARAF/RAF1/WNT11/WNT3/SOS2/CDKN2B/MAP2K2/AKT3/GSK3B/PIK3R2	2.95395559751187
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	31/2452	75/9376	1.5805111473627	GSTT1/PIK3R1/GSTM3/FAS/XPA/AKT2/TOP2B/ERCC1/PDPK1/PIK3CA/ATM/CDKN1A/BCL2/MAPK1/BIRC2/REV3L/SLC31A1/MSH6/BBC3/MSH3/XIAP/BCL2L1/ATP7A/GSTM2/MGST2/FADD/POLH/AKT3/PIK3R2/APAF1/CASP3	3.00361119807419
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	42/2452	109/9376	1.47339748866306	CD36/CREB3L1/TNFRSF1A/PPP1R3C/IRS1/PIK3R1/MLXIP/GFPT2/STAT3/AKT2/SLC27A3/PDPK1/TRIB3/SOCS3/CREB1/PIK3CA/CPT1A/PTEN/PTPN1/RPS6KA3/PRKAA1/NOS3/RPS6KB1/G6PC3/CREB3/NFKB1/PPARA/MAPK10/OGT/MAPK8/PPP1R3E/ACACB/AKT3/GSK3B/PIK3R2/GFPT1/IKBKB/RELA/PPP1R3D/PRKAB1/SREBF1/PRKCD	2.95826420563176
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	64/2452	180/9376	1.35957948160232	HLA-B/HLA-A/BST2/TNFRSF1A/HLA-DRA/HLA-F/TSC2/IFNGR2/PIK3R1/HLA-C/EIF4EBP1/B2M/FAS/HLA-E/AKT2/CD74/HLA-DPA1/IFNAR1/SOCS3/HCFC2/PIK3CA/TRADD/HLA-DPB1/HLA-DQA2/HLA-DMA/BCL2/PML/BIRC2/TAB2/TNFRSF14/TLR3/SP100/JAK2/RNASEL/NFKB1/TAPBPL/TAPBP/IFNGR1/RHEB/IFIH1/MAP3K7/HLA-DMB/TSC1/BCL2L1/HLA-DRB1/EIF2B4/SRSF4/IRAK4/SRSF5/FADD/AKT3/IKBKG/POU2F1/TRAF6/PIK3R2/IKBKB/HLA-DQA1/APAF1/RELA/TICAM1/TRAF5/SRC/CASP3/SRSF1	2.8986715949594
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	46/2452	122/9376	1.44176717567459	PIK3R1/MAPK14/FYN/CDK4/PPP2CB/AKT2/KRAS/PDPK1/JUN/MALT1/PIK3CA/NFATC3/FOS/SOS1/NFATC2/PPP3CB/MAPK1/PPP2R5E/DLG1/PPP3CC/NFKB1/RAF1/MAP3K7/PPP2R2D/MAPK10/SOS2/NCK2/MAPK8/MAP2K7/MAP2K2/PPP2R3C/PPP2R5B/AKT3/CD4/GSK3B/IKBKG/LAT/PLCG1/PIK3R2/PPP2R1A/PPP3R1/PPP2R5A/IKBKB/NCK1/NFATC1/RELA	2.92264423335869
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	39/2452	101/9376	1.4765235087946	WNT2/CREB3L1/FZD2/CALM2/WNT2B/WNT5B/ADCY3/KITLG/CREBBP/GNAI1/PRKCA/FZD1/FZD7/CAMK2D/ADCY9/EDNRB/PLCB1/KRAS/GNAI2/CREB1/CAMK2A/PRKACA/FZD4/DVL3/TCF7L1/DVL2/MAPK1/ADCY7/PRKACB/FZD6/ADCY6/CREB3/RAF1/WNT11/WNT3/POMC/MAP2K2/GSK3B/MC1R	2.86520301997705
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	49/2452	133/9376	1.40877479179188	CREB3L1/CALM2/GNAI1/ITPR1/PRKCA/MAPK14/GNG11/CAMK2D/COMT/PLCB1/PPP2CB/AKT2/GNAI2/CREB1/CAMK2A/PRKACA/FOS/ATF2/CLOCK/PPP3CB/ITPR2/GNB4/PPP2R5E/PRKACB/ATF6B/KIF5B/PPP3CC/CREB3/MAOA/ARRB1/PPP2R2D/GNB3/MAPK10/KCNJ5/MAPK8/DRD4/GNB2/GSK3A/CACNA1C/PPP2R3C/PPP2R5B/AKT3/GSK3B/GNGT1/PPP2R1A/PPP2R5A/GNG12/KCNJ6/ATF4	2.82534047756985
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	15/2452	30/9376	1.91190864600326	PIGC/PIGM/PIGT/PIGQ/PIGH/GPAA1/PIGP/PIGL/PIGX/PIGV/PGAP3/PIGF/MPPE1/PIGS/PIGU	2.97691485956958
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	20/2452	44/9376	1.73809876909388	MAN1A1/MAN1C1/CHST9/MGAT2/HEXA/ALG1/MGAT4B/ALG2/MAN1B1/HEXB/ALG12/B4GALT2/RPN1/ALG14/KRTCAP2/B4GALT3/ST3GAL3/STT3A/ALG11/DAD1	2.92025513163742
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	40/2452	105/9376	1.45669230171677	CALM2/RRAS/ITPR1/PIK3R1/CASP1/MAPK14/NFATC4/AKT2/KRAS/JUN/CYLD/MALT1/PIK3CA/NFATC3/NFATC2/PPP3CB/ITPR2/MAPK1/LSP1/ARHGEF12/BCL3/PPP3CC/KSR1/NFKB1/MRAS/RAF1/MAPK10/MAPK8/NFKB2/AKT3/IKBKG/PIK3R2/PPP3R1/IKBKB/NFATC1/RELA/MAPKAPK2/SRC/PLK3/PRKCD	2.80041497572874
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	24/2452	56/9376	1.63877883943137	MAN1A1/MAN1C1/MGAT2/ALG1/MGAT4B/ALG2/ALG5/MAN1B1/MGAT3/DOLK/ALG12/ST6GAL2/B4GALT2/RPN1/ALG14/KRTCAP2/B4GALT3/DPM1/STT3A/DHRSX/MOGS/ALG11/ALG8/DAD1	2.85301411213396
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	26/2452	62/9376	1.60353628374467	ADCY3/IRS1/CRYAB/PIK3R1/FOXO3/ADCY9/IGF1R/HSPA1A/AKT2/KRAS/PIK3CA/PRKACA/CAT/ADCY7/PRKACB/PRKAA1/RPS6KB1/ADCY6/HSPA1B/EIF4EBP2/SIRT1/AKT1S1/HSPA6/AKT3/PIK3R2/PRKAB1	2.83725554766544
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	31/2452	78/9376	1.51972225707952	MINPP1/PLCB1/CDIPT/PLCD3/PIK3CA/SACM1L/INPP1/INPP5K/PTEN/IP6K1/PIKFYVE/PIK3C3/MTMR2/PI4KB/IP6K3/PLCE1/PIP4K2A/INPP5A/ITPKA/MTMR6/ITPKC/MTMR3/IP6K2/PIP4K2B/IPMK/OCRL/PIP5K1C/PLCG1/PIP5K1A/INPPL1/INPP5E	2.74278135036666
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	59/2452	168/9376	1.34288821564515	PRLR/PDGFRA/CCND2/IL6ST/FHL1/LIFR/EPOR/CISH/CNTFR/IL11RA/CCND3/SOCS1/IL6R/CREBBP/OSMR/PDGFA/IFNGR2/PIK3R1/PDGFRB/IL4R/CTF1/CCND1/STAT3/SOCS2/AKT2/PIAS1/STAT6/IFNAR1/SOCS5/SOCS3/PIK3CA/CDKN1A/JAK3/SOS1/MYC/IL10RB/BCL2/IL11/CLCF1/PIAS2/CSH2/JAK2/GHR/RAF1/CSH1/IFNGR1/PIAS3/STAM2/STAT5A/BCL2L1/SOS2/STAM/TSLP/AKT3/STAT5B/SOCS6/PIK3R2/PTPN2/PIAS4	2.66865164626499
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	55/2452	155/9376	1.3568383939378	HLA-B/CD36/MRC2/HLA-A/COLEC12/C1R/HLA-DRA/HLA-F/HLA-C/THBS1/TFRC/ATP6V0D1/ATP6V1G1/ITGB5/DYNC1LI2/HLA-E/DYNC2H1/HLA-DPA1/TUBB2A/M6PR/HLA-DPB1/RAB5A/HLA-DQA2/HLA-DMA/STX18/PLA2R1/LAMP2/PIKFYVE/PIK3C3/CTSS/ATP6V1C1/FCGR3A/TUBA3D/LAMP1/THBS3/DYNC1H1/ATP6AP1/TCIRG1/RAB7A/MSR1/ATP6V0A1/OLR1/ATP6V1D/HLA-DMB/STX12/TUBA1A/SEC61A1/HLA-DRB1/EEA1/SEC61A2/HLA-DQA1/ITGB2/ATP6V0B/HGS/ATP6V0A2	2.6657275207199
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	51/2452	142/9376	1.3733428302277	TNFRSF1A/TGFBR2/TGFBR1/CSF1/IL1R1/SOCS1/ITPR1/IFNGR2/PIK3R1/MAPK14/FYN/AKT2/JUN/IFNAR1/CYLD/SOCS3/TNFRSF11B/CREB1/PIK3CA/FOS/TGFB2/TMEM64/NFATC2/PPP3CB/ITPR2/JUND/MAPK1/TAB2/JUNB/PPP3CC/TREM2/FCGR3A/NFKB1/FOSB/SIRPA/IFNGR1/MAP3K7/MAPK10/SQSTM1/MAPK8/MAP2K7/ACP5/NFKB2/AKT3/IKBKG/TRAF6/PIK3R2/PPP3R1/IKBKB/NFATC1/RELA	2.66762263659126
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	22/2452	51/9376	1.64948981223811	ADCY3/PRKCA/ADCY9/ATP6V0D1/ATP6V1G1/TJP1/ARF1/KDELR3/PRKACA/KDELR1/PRKACB/ATP6V1C1/ATP6AP1/TCIRG1/ATP6V0A1/ATP6V1D/SLC12A2/SEC61A1/SEC61A2/PLCG1/ATP6V0B/ATP6V0A2	2.76758107721632
Organismal Systems	Immune system	hsa04611	Platelet activation	46/2452	126/9376	1.39599678914524	COL1A2/COL1A1/COL3A1/ADCY3/PRKG1/GNAI1/ITPR1/PIK3R1/MAPK14/ADCY9/FYN/LYN/P2RY1/GUCY1A2/ARHGAP35/ORAI1/ROCK2/PTGIR/ROCK1/PLCB1/AKT2/TBXA2R/GNAI2/PIK3CA/PRKACA/GNA13/ITPR2/TLN2/PRKCI/MAPK1/ARHGEF12/ADCY7/PRKACB/NOS3/RAP1A/ADCY6/PPP1R12A/ADAMTS13/MYLK/PLA2G4A/P2RX1/MYLK3/AKT3/PIK3R2/PTGS1/SRC	2.66301377096889
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	72/2452	212/9376	1.29865492936071	HGF/PDGFRA/FGF7/CSF1/CALM2/RRAS/ENAH/ADCY3/KITLG/PDGFC/PFN2/GNAI1/VEGFA/PDGFA/PRKCA/VEGFC/PIK3R1/LPAR1/MAPK14/PDGFRB/FGFR1/THBS1/FGF2/FGFR2/ADCY9/BCAR1/IGF1R/P2RY1/ADORA2B/EFNA5/TEK/FGFR4/PLCB1/ANGPT1/AKT2/KRAS/GNAI2/PIK3CA/DOCK4/ARAP3/KRIT1/MAGI2/TLN2/PRKD2/PRKCI/MAPK1/PRKD1/RASSF5/ADCY7/FGFR3/EFNA2/RALGDS/MAGI3/RAP1A/ADCY6/PLCE1/MRAS/RAF1/RAPGEF2/CRK/VEGFB/MAP2K2/AKT3/LPAR5/LAT/PLCG1/PIK3R2/EVL/PARD6G/PARD3/SRC/ITGB2	2.61735372018713
Human Diseases	Infectious disease: viral	hsa05162	Measles	49/2452	136/9376	1.37769887726706	CCND2/CCND3/CDK6/PIK3R1/CDK4/CCND1/FAS/STAT3/RCHY1/HSPA1A/AKT2/RAB9A/JUN/IFNAR1/PIK3CA/FOS/TRADD/JAK3/BCL2/CD46/TAB2/CSNK2A1/CDKN1B/BBC3/HSPA1B/NFKB1/ADAR/IFIH1/MAP3K7/MSN/CSNK2B/STAT5A/BCL2L1/MAPK10/CSNK2A2/MAPK8/HSPA6/IRAK4/FADD/AKT3/GSK3B/STAT5B/IKBKG/TRAF6/PIK3R2/IKBKB/APAF1/RELA/CASP3	2.6402588313467
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	73/2452	216/9376	1.29230862183554	CD36/VCAM1/TNFRSF1A/CALM2/VLDLR/ITPR1/PRKCA/PIK3R1/CASP1/MAPK14/ABCA1/CAMK2D/HSP90B1/LYN/ROCK2/PLCB1/FAS/STAT3/MIB1/HSPA1A/AKT2/KRAS/PDPK1/JUN/PIK3CA/RXRB/CAMK2A/NFATC3/FOS/IL18/LY96/NFATC2/PPP3CB/MMP9/BCL2/MAPK1/TAB2/PPP3CC/MAP2K4/NOS3/JAK2/RAP1A/NFE2L2/HSPA1B/NFKB1/CASP7/MAP3K7/OLR1/ATF6/BCL2L1/MAPK10/MAPK8/MAP2K7/HSPA6/IRAK4/AKT3/GSK3B/DDIT3/EIF2AK3/IKBKG/PLCG1/POU2F1/TRAF6/PIK3R2/PPP3R1/IKBKB/NFATC1/APAF1/RELA/TICAM1/ATF4/SRC/CASP3	2.58635482273098
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	28/2452	70/9376	1.52952691680261	CD36/TNFRSF1A/IRS1/STAT3/APPL1/AKT2/STK11/SOCS3/RXRB/ACSL3/TRADD/CPT1A/PRKAA1/JAK2/G6PC3/NFKB1/CAMKK2/ADIPOR1/PPARA/MAPK10/MAPK8/POMC/ACACB/AKT3/IKBKG/IKBKB/RELA/PRKAB1	2.64620129965445
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	21/2452	49/9376	1.63877883943137	CREB3L1/GNAI1/GPSM1/JUN/GNAI2/CREB1/PRKACA/BDNF/ATF2/DLG4/PRKACB/ATF6B/GRIN2D/RGS9/CREB3/NFKB1/FOSB/MAOA/CDK5/RELA/ATF4	2.6677486828999
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	23/2452	55/9376	1.59905086756637	SGMS1/NEU1/CERS2/DEGS1/HEXA/SMPD1/ASAH1/CERS6/ACER3/HEXB/UGCG/CERK/GLA/B4GALT6/SGMS2/GLB1/CERS4/SPTLC2/SGPL1/SPTLC1/SAMD8/KDSR/ARSA	2.6514359090603
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	39/2452	105/9376	1.42027499417385	VCAM1/TNFRSF1A/IL1R1/UBE2I/LYN/LTBR/TNFSF13B/GADD45B/CYLD/MALT1/ATM/TRADD/LY96/RIPK1/BCL2/ERC1/EDA/PLAU/BIRC2/TAB2/CSNK2A1/GADD45G/NFKB1/MAP3K7/CSNK2B/XIAP/BCL2L1/CSNK2A2/IRAK4/NFKB2/IKBKG/LAT/PLCG1/TRAF6/IKBKB/RELA/TICAM1/TRAF5/PIAS4	2.57710581760293
NA	NA	hsa04518	Integrin signaling	54/2452	154/9376	1.34081905044385	HGF/SPP1/PDGFRA/CCND2/VCAM1/LAMA2/LAMB2/VTN/LAMC3/COL6A1/COL6A2/COL1A2/COL1A1/FBN1/ITGA1/CCND3/PDGFC/VEGFA/ICAM4/PDGFA/VEGFC/PIK3R1/PDGFRB/THBS1/FN1/IGF1R/FREM1/ITGA11/ITGB5/CCND1/AKT2/COL4A5/LAMB1/PIK3CA/TNXB/LAMC1/FLNA/COL6A6/LIMS2/TLN2/FERMT2/ITGA4/ILK/THBS3/COL9A2/COL9A3/NCK2/VEGFB/AKT3/GSK3B/PIK3R2/FRAS1/SRC/ITGB2	2.53769255243817
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	42/2452	115/9376	1.39652457621108	CREB3L1/SLC18A3/ADCY3/GNAI1/ITPR1/PRKCA/PIK3R1/GNG11/CAMK2D/ADCY9/FYN/PLCB1/AKT2/KRAS/GNAI2/CREB1/PIK3CA/CAMK2A/PRKACA/FOS/ITPR2/CHAT/BCL2/GNB4/CHRM2/KCNJ12/MAPK1/ADCY7/PRKACB/JAK2/ADCY6/CREB3/GNA11/GNB3/GNB2/CACNA1C/AKT3/GNGT1/PIK3R2/GNG12/KCNJ6/ATF4	2.54599431303255
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	69/2452	205/9376	1.28704094218756	HLA-B/CCND2/IL6ST/CREB3L1/HLA-A/CCND3/CREBBP/RBPJ/HLA-F/CDK6/RBL2/PIK3R1/HLA-C/USP7/ATP6V0D1/LYN/GSN/CDK4/LTBR/CCND1/STAT3/CHD4/HLA-E/KRAS/UBE3A/JUN/CREB1/PIK3CA/PRKACA/CDKN1A/TRADD/ATF2/JAK3/HDAC7/MAPK1/PRKACB/ATF6B/DLG1/CDKN1B/SP100/UBR4/CREB3/HDAC9/HDAC3/NFKB1/KAT2B/YWHAH/SCIN/GTF2H2/STAT5A/GTF2A1/HDAC4/GTF2H1/CDKN2B/GTF2E2/NFKB2/GTF2H2C/STAT5B/IKBKG/MAD1L1/HDAC11/PIK3R2/RELA/MAPKAPK2/TRAF5/ATF4/SRC/SNW1/CASP3	2.47274750440341
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	35/2452	93/9376	1.43907102387342	TGFBR2/LMO7/TGFBR1/SSX2IP/CREBBP/SNAI2/FGFR1/SMAD3/WASL/FYN/SMURF2/IGF1R/ROCK2/ROCK1/SMAD4/WASF2/TJP1/KRIT1/PTPRJ/TCF7L1/MAPK1/PTPN1/SORBS1/CSNK2A1/RAP1A/MYL9/MAP3K7/CSNK2B/RADIL/CSNK2A2/CCM2/PTPRM/FER/PARD3/SRC	2.53220824021705
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	27/2452	68/9376	1.51828039535553	RUNX1T1/PIK3R1/EIF4EBP1/CCND1/STAT3/RARA/AKT2/KRAS/PIK3CA/SOS1/MYC/TCF7L1/MAPK1/PML/RPS6KB1/ARAF/NFKB1/RAF1/STAT5A/SOS2/MAP2K2/AKT3/STAT5B/IKBKG/PIK3R2/IKBKB/RELA	2.55245675009185
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	26/2452	65/9376	1.52952691680261	CREB3L1/HSD3B2/ADCY3/ITPR1/ADCY9/ORAI1/PLCB1/MRAP/KCNK3/PBX1/CREB1/PRKACA/ATF2/ITPR2/ADCY7/PRKACB/ATF6B/SP1/ADCY6/CREB3/GNA11/POMC/CACNA1C/CACNA1G/PDE8B/ATF4	2.54925862587343
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	9/2452	16/9376	2.15089722675367	GBGT1/ST3GAL2/ST3GAL1/HEXA/HEXB/B3GALNT1/GLA/NAGA/A4GALT	2.74173800454607
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	18/2452	41/9376	1.67874905502725	VEGFA/DAPK1/THBS1/CDK4/CCND1/KRAS/CDKN1A/MYC/MMP2/MMP9/MAPK1/FGFR3/ARAF/RAF1/TYMP/MAP2K2/RASSF1/SRC	2.59185885055679
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	38/2452	103/9376	1.41072870967231	TNFRSF1A/TGFBR2/TGFBR1/GNAI1/IFNGR2/PIK3R1/MAPK14/TGFB3/PLCB1/FAS/PPP2CB/AKT2/JUN/GNAI2/PIK3CA/FOS/TGFB2/GNA14/MAPK1/MAP2K4/KNG1/SERPINE1/NFKB1/GNA11/IFNGR1/PPP2R2D/MAPK10/MAPK8/IRAK4/FADD/AKT3/IKBKG/TRAF6/PIK3R2/PPP2R1A/IKBKB/RELA/TICAM1	2.49419775968309
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	36/2452	97/9376	1.41914868569314	CALM2/ADCY3/PRKG1/GNAI1/ITPR1/PRKCA/GNG11/CAMK2D/ADCY9/GUCY1A2/PLCB1/NOS1AP/GNAI2/CREB1/CAMK2A/PRKACA/FOS/GNB4/MAPK1/ADCY7/PRKACB/GRIN2D/RYR2/ADCY6/PER1/RASD1/GNB3/KCNJ5/GNB2/PER3/CACNA1C/CACNA1G/GNGT1/RYR1/GNG12/KCNJ6	2.46928222396506
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	40/2452	110/9376	1.3904790152751	TIMP1/IL6R/CREBBP/VEGFA/PRKCA/IFNGR2/PIK3R1/TFRC/EIF4EBP1/CAMK2D/IGF1R/LTBR/PFKM/TEK/STAT3/ANGPT1/AKT2/EGLN2/PIK3CA/CAMK2A/PDHB/CDKN1A/BCL2/MAPK1/EPAS1/CDKN1B/NOS3/RPS6KB1/SERPINE1/NFKB1/IFNGR1/CUL2/MAP2K2/AKT3/HIF1A/ENO3/PLCG1/PIK3R2/RELA/ENO2	2.45140594843722
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	24/2452	60/9376	1.52952691680261	VEGFA/PRKCA/PIK3R1/MAPK14/SHC2/AKT2/KRAS/PIK3CA/MAPKAPK3/NFATC2/PPP3CB/HSPB1/MAPK1/PPP3CC/NOS3/RAF1/PLA2G4A/MAP2K2/AKT3/PLCG1/PIK3R2/PPP3R1/MAPKAPK2/SRC	2.44859110644346
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	8/2452	14/9376	2.18503845257516	CHST2/ST3GAL2/ST3GAL1/B4GALT4/B4GALT2/B4GALT3/ST3GAL3/CHST1	2.64045933662159
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	39/2452	108/9376	1.38082291100236	UBE2I/TNPO1/TPR/KPNA5/THOC2/UPF3A/RNPS1/PHAX/SEC13/POM121/DDX19A/AHCTF1/POM121C/XPO6/SNUPN/NUP93/SENP2/NUP35/NXT1/KPNA3/AAAS/NUP133/THOC6/RANBP2/NUP54/DDX39B/NUP188/IPO9/IPO13/KPNA6/XPOT/RAE1/NUP214/NMD3/IPO8/SUMO1/RANBP17/XPO4/NUP153	2.36869571907949
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	82/2452	253/9376	1.23933999187563	TNFRSF1A/UBB/IL1R1/CAST/PFN2/CAPN2/ITPR1/PIK3R1/CASP1/MAPK14/CD44/FOXO3/WASL/BCAR1/ROCK2/ROCK1/PLCB1/WIPI2/AKT2/WASF2/ARF1/ARHGEF2/PLCD3/JUN/RRAGA/MALT1/PIK3CA/ATM/RRAGB/IL18/TRADD/RIPK1/ITPR2/BCL2/TLN2/CALCOCO2/MAPK1/TAB2/CAPNS1/FBXW11/RBCK1/TIFA/PIK3C3/SHARPIN/RPS6KB1/MYL9/PLCE1/ELMO1/NFKB1/ILK/ATG14/MAP3K7/PIK3R4/BTRC/CRK/U2AF1L4/UBE2D2/BCL2L1/MAPK10/NOD1/CYTH3/SQSTM1/MAPK8/RRAGC/MAP1LC3B/ELMO2/DOCK1/CYTH1/AKT1S1/CYTH2/GSK3A/AKT3/GSK3B/IKBKG/PLCG1/TRAF6/PIK3R2/IKBKB/RELA/TRAF5/SRC/PRKCD	2.29654011888487
Human Diseases	Cancer: specific types	hsa05218	Melanoma	28/2452	73/9376	1.46666964624908	HGF/PDGFRA/FGF7/PDGFC/CDK6/PDGFA/PIK3R1/PDGFRB/FGFR1/FGF2/IGF1R/CDK4/CCND1/GADD45B/POLK/AKT2/KRAS/PIK3CA/CDKN1A/PTEN/MAPK1/DDB2/GADD45G/ARAF/RAF1/MAP2K2/AKT3/PIK3R2	2.38191804705217
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	21/2452	52/9376	1.54423390638725	CD36/APOC1/ANGPTL4/APOE/PLTP/LRP1/ABCA1/CYP27A1/STARD3NL/LDLRAP1/SOAT1/LRPAP1/SORT1/LPL/NPC1/LCAT/MYLIP/STARD3/LIPA/OSBPL5/TSPO	2.3418198140942
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	16/2452	37/9376	1.65354261275958	CCND1/GADD45B/TPR/TFG/POLK/KRAS/RXRB/CDKN1A/MYC/TCF7L1/MAPK1/DDB2/GADD45G/MAP2K2/CCDC6/PAX8	2.3702378327891
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	75/2452	232/9376	1.23614783146763	PDGFRA/IQGAP2/FGF7/C7/ITGA1/CFL2/RRAS/ENAH/PDGFC/PFN2/MYH10/PDGFA/PIK3R1/LPAR1/PDGFRB/FGFR1/FGF2/FGFR2/WASL/FN1/BCAR1/GSN/ARHGAP35/ITGA11/ITGB5/ROCK2/FGFR4/ROCK1/APC/ABI2/AKT2/WASF2/KRAS/PIK3CA/RGCC/BDKRB1/FGD1/SOS1/GNA13/NCKAP1/CHRM2/MAPK1/ARHGEF12/FGFR3/TMSB4X/PIKFYVE/KNG1/ITGA4/LIMK1/MYL9/PPP1R12B/ARAF/MRAS/PIP4K2A/PPP1R12A/RAF1/MSN/SCIN/CRK/MYLK/SOS2/SSH1/MYLK3/DOCK1/PIP4K2B/MAP2K2/SLC9A1/AKT3/LPAR5/PIP5K1C/PIK3R2/PIP5K1A/GNG12/SRC/ITGB2	2.16734070258138
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	37/2452	104/9376	1.36039653657924	PLD3/LPCAT2/AGPAT4/SGMS1/LPGAT1/AGPAT2/PLA2G15/LPIN2/CDIPT/CHPT1/CEPT1/PLD1/MBOAT2/GPAT2/AGPAT3/CHAT/PGS1/LPIN1/LCAT/SGMS2/PTDSS2/AGPAT1/PTDSS1/LPCAT3/CHKB/GNPAT/PLA2G4A/DGKQ/DGKH/GPD1L/PISD/DGKE/SAMD8/DGKD/CHKA/ETNK2/GDPD5	2.19926675060725
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	8/2452	15/9376	2.03936922240348	ST3GAL2/ST3GAL1/HEXA/HEXB/ST6GALNAC6/ST6GALNAC4/GLB1/ST3GAL5	2.39729622144083
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	35/2452	98/9376	1.36564903285947	CREB3L1/ATP1B1/HSD3B2/ATP2B1/CALM2/ADCY3/ITPR1/PRKCA/ATP1A1/CAMK2D/ADCY9/ORAI1/PLCB1/KCNK3/ATP1A2/CREB1/CAMK2A/PRKACA/ATF2/ITPR2/PRKD2/PRKD1/ADCY7/PRKACB/ATF6B/LIPE/ADCY6/CREB3/GNA11/ATP2B4/KCNJ5/POMC/CACNA1C/CACNA1G/ATF4	2.1652977486005
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	70/2452	217/9376	1.23348944903436	CREB3L1/FGF7/KLF4/CCND3/ADCY3/GSTT1/ADRB3/JAG1/NOTCH2/PAQR8/GNAI1/VEGFA/PRKCA/PIK3R1/AHR/FGF2/EIF4EBP1/ADCY9/HSP90B1/GSTM3/CCND1/STAT3/AIP/EPHX2/AKT2/KRAS/JUN/GNAI2/CREB1/EPHX1/PIK3CA/KPNA5/RXRB/VDR/PRKACA/FOS/ATF2/SOS1/MYC/BCL2/MAPK1/ADCY7/PRKACB/ATF6B/RPS6KA3/RPS6KB1/JAK2/ADCY6/CREB3/NFKB1/RAF1/DLL4/XIAP/STAT5A/ARRB1/KPNA3/PPARA/SOS2/GSTM2/MGST2/MAP2K2/CACNA1C/AKT3/STAT5B/KPNA6/PIK3R2/RELA/ATF4/SRC/CHRNA9	2.07081088576861
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	9/2452	18/9376	1.91190864600326	NEU1/FUCA2/HEXA/HEXB/MANBA/GLB1/MAN2B2/MAN2C1/FUCA1	2.30442939828732
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	26/2452	71/9376	1.40027112101647	MAPK14/ATP6V0D1/LYN/ATP6V1G1/ADAM10/TJP1/JAM3/JUN/MAP2K4/ATP6V1C1/NFKB1/ATP6AP1/TCIRG1/ATP6V0A1/ATP6V1D/MAPK10/NOD1/MAPK8/IKBKG/PLCG1/IKBKB/RELA/SRC/CASP3/ATP6V0B/ATP6V0A2	2.0146174189475
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	52/2452	158/9376	1.25847151382493	CCND2/CCND3/CREBBP/ABL1/CDK6/RBL2/ATRX/SMAD3/CDK4/NIPBL/TGFB3/CCND1/GADD45B/SMAD4/PPP2CB/CDC25B/ATM/CDKN1A/TGFB2/CHEK2/STAG2/MYC/PPP2R5E/RAD21/CDKN2D/CDC16/CDKN1B/STAG1/ANAPC16/MAU2/GADD45G/MAD2L1BP/ANAPC13/CDC27/E2F4/YWHAH/FZR1/ANAPC10/CDKN2B/PDS5B/MAD2L2/ATR/PPP2R5B/ESCO1/GSK3B/ORC3/MAD1L1/ORC4/PPP2R1A/PPP2R5A/CDC23/SMC3	1.94980068902887
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	24/2452	65/9376	1.41187100012549	SPP1/ITPR1/PRKCA/PIK3R1/TRPC1/PLCB1/AKT2/KRAS/PIK3CA/GABBR1/ITPR2/MAPK1/GNA11/RAF1/ARRB1/KCNJ5/HCN3/GPER1/MAP2K2/CACNA1C/AKT3/CACNA1G/PIK3R2/KCNJ6	1.9828372581264
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	36/2452	105/9376	1.31102307154509	DES/LAMA2/SGCE/TNNI3/ITGA1/ADCY3/SGCA/SGCB/SGCD/ADCY9/SNTB1/CACNA2D1/ITGA11/SNTB2/ITGB5/TGFB3/SNTA1/MYL3/DMD/PRKACA/TGFB2/ADCY7/PRKACB/CACNB4/LMNA/SLC8A1/ITGA4/RYR2/ADCY6/CACNB2/EMD/TNNT2/DTNA/CACNA1C/CACNB1/CACNB3	1.9071783432255
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	22/2452	59/9376	1.4258301766804	ADCY3/IRS1/ADRB3/PRKG1/GNAI1/PIK3R1/ADCY9/PDE3B/NPY1R/AKT2/GNAI2/PIK3CA/PRKACA/ADCY7/PRKACB/LIPE/ADCY6/ADORA1/AKT3/PIK3R2/PTGS1/PNPLA2	1.95250310996749
Organismal Systems	Endocrine system	hsa04924	Renin secretion	25/2452	69/9376	1.38544104782845	CALM2/ADRB3/GNAI1/ITPR1/PDE3A/PTGER2/PDE3B/GUCY1A2/ORAI1/PLCB1/GNAI2/CREB1/PRKACA/PPP3CB/ITPR2/PRKACB/PPP3CC/KCNMA1/ADCY6/ADORA1/AQP1/CACNA1C/PPP3R1/CTSB/PTGER4	1.91225142499284
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	15/2452	38/9376	1.50940156263415	PGM3/GCK/GFPT2/HEXA/HEXB/GNPDA2/UGDH/GMPPA/GNPDA1/GALK1/UAP1L1/PMM2/GALT/GFPT1/GALK2	1.87237346567601
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	61/2452	193/9376	1.20856401457201	CXCL14/ADCY3/GNAI1/PIK3R1/GNG11/FOXO3/ADCY9/LYN/BCAR1/SHC2/ROCK2/ROCK1/PLCB1/STAT3/AKT2/KRAS/GNAI2/PIK3CA/PRKACA/JAK3/SOS1/GNB4/MAPK1/ADCY7/PRKACB/SHC1/JAK2/RAP1A/XCL1/ADCY6/ELMO1/NFKB1/RAF1/GRK5/CCL18/CCL28/CXCL9/CRK/CXCL16/ARRB1/GNB3/PF4/SOS2/CCL26/GNB2/GSK3A/AKT3/GSK3B/STAT5B/IKBKG/GNGT1/PLCG1/PIK3R2/IKBKB/PARD3/RELA/GNG12/SRC/PPBP/CCR10/PRKCD	1.74218023224493
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	31/2452	91/9376	1.30261907749673	CD81/IFITM1/PIK3R1/LYN/AKT2/KRAS/JUN/MALT1/PIK3CA/NFATC3/FOS/SOS1/NFATC2/PPP3CB/MAPK1/PPP3CC/NFKB1/RAF1/CD22/SOS2/MAP2K2/AKT3/CD19/GSK3B/IKBKG/PIK3R2/PPP3R1/IKBKB/NFATC1/RELA/INPPL1	1.72620904014902
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	70/2452	226/9376	1.18436818778963	CREB3L1/FXYD1/ATP1B1/TNNI3/ATP2B1/CALM2/RRAS/ADCY3/CREBBP/GNAI1/PDE3A/PIK3R1/ATP1A1/CAMK2D/ADCY9/PTGER2/PDE3B/ORAI1/ROCK2/NPY1R/ROCK1/SSTR1/AKT2/GLI3/ATP1A2/PDE4A/JUN/GNAI2/PLD1/CREB1/PIK3CA/CAMK2A/ARAP3/PRKACA/BDNF/FOS/GABBR1/CHRM2/MAPK1/ADCY7/PRKACB/GRIN2D/ABCC4/LIPE/RAP1A/RYR2/ADCY6/MYL9/CREB3/PLCE1/NFKB1/PPP1R12A/RAF1/GIP/PTCH1/VIPR2/ATP2B4/ADORA1/PPARA/MAPK10/MAPK8/POMC/PDE4B/MAP2K2/CACNA1C/SLC9A1/AKT3/PIK3R2/NFATC1/RELA	1.66954066241447
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	28/2452	82/9376	1.30569370946564	HLA-B/HLA-A/HLA-DRA/HLA-F/HLA-C/B2M/HLA-E/HSPA1A/CD74/HLA-DPA1/CREB1/HLA-DPB1/HLA-DQA2/HLA-DMA/CTSS/HSPA1B/RFXAP/TAPBPL/TAPBP/HLA-DMB/NFYC/RFXANK/HLA-DRB1/RFX5/HSPA6/CD4/HLA-DQA1/CTSB	1.65447205317741
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	6/2452	12/9376	1.91190864600326	GGCX/VKORC1L1/COQ7/COQ5/COQ4/NQO1	1.88095582201334
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	49/2452	154/9376	1.21666913836571	CREB3L1/ATP1B1/TNNI3/ATP2B1/CALM2/ADCY3/GNAI1/PRKCA/ATP1A1/MAPK14/CAMK2D/ADCY9/CACNA2D1/PLCB1/PPP2CB/AKT2/ATP1A2/MYL3/GNAI2/CREB1/CAMK2A/PRKACA/ATF2/BCL2/MAPK1/PPP2R5E/ADCY7/PRKACB/CACNB4/ATF6B/SLC8A1/RYR2/ADCY6/CREB3/SCN7A/CACNB2/PPP2R2D/TNNT2/ATP2B4/CACNA1C/PPP2R3C/SLC9A1/PPP2R5B/AKT3/PPP2R1A/PPP2R5A/CACNB1/CACNB3/ATF4	1.61328909888638
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	30/2452	89/9376	1.28892717708085	SPP1/CD36/LAMA2/LAMB2/VTN/LAMC3/COL6A1/COL6A2/COL1A2/COL1A1/ITGA1/CD44/THBS1/FN1/FREM1/ITGA11/ITGB5/COL4A5/LAMB1/TNXB/LAMC1/COL6A6/ITGA4/SV2A/THBS3/COL9A2/COL9A3/CD47/FRAS1/SDC1	1.6297200795527
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	62/2452	200/9376	1.18538336052202	TNFRSF1A/IL1R1/ABL1/MYH10/LPAR1/CASP1/MAPK14/WASL/FYN/CLDN11/ROCK2/ROCK1/FAS/MYO1D/MYO1C/WASF2/TJP1/ARF1/ARHGEF2/JUN/TUBB2A/SEC24D/FOS/IL18/TRADD/WIPF1/GNA13/NCKAP1/RIPK1/MAPK1/ARHGEF12/SEC24B/TAB2/ARHGEF11/CLDN23/TUBA3D/NFKB1/CASP7/MAP3K7/TUBA1A/MAPK10/MYO10/CYTH3/NCK2/MAPK8/CYTH1/MYO5A/CYTH2/CLDN12/IRAK4/FADD/WIPF2/LPAR5/IKBKG/TRAF6/IKBKB/NCK1/RELA/CLDN15/SRC/CASP3/RAB1A	1.57698073349488
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	23/2452	66/9376	1.33254238963864	MAF/HLA-DRA/IFNGR2/SMAD3/IL4R/TGFB3/STAT3/STAT6/HLA-DPA1/JUN/TGFB2/IL18/HLA-DPB1/HLA-DQA2/HLA-DMA/IL18R1/NFKB1/IFNGR1/HLA-DMB/HLA-DRB1/HLA-DQA1/NFATC1/RELA	1.61328643480131
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	58/2452	187/9376	1.18599680714641	TXNIP/ANTXR2/GABARAPL2/NLRP1/ANTXR1/IFI16/ITPR1/CASP1/MAPK14/AIM2/PKN1/NEK7/PLCB1/GABARAPL1/TRIP6/JUN/IFNAR1/GABARAP/IL18/PKN2/RIPK1/ITPR2/BCL2/MAPK1/TRPV2/BIRC2/TAB2/TRPM7/RBCK1/SHARPIN/TP53BP1/RNASEL/GBP3/NFKB1/NLRX1/GPSM3/MAP3K7/XIAP/CARD16/BCL2L1/MAPK10/NOD1/MAPK8/MAP1LC3B/MFN2/IRAK4/FADD/GBP4/CARD6/IKBKG/TRAF6/IKBKB/GBP1/RELA/TICAM1/TRAF5/CTSB/PRKCD	1.52883109799855
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	19/2452	53/9376	1.3708024254363	ATP1B1/ATP2B1/AP2M1/PRKCA/ATP1A1/PTH1R/ADCY9/PLCB1/CLTC/ATP1A2/VDR/PRKACA/AP2A1/PRKACB/DNM1/SLC8A1/ADCY6/AP2B1/ATP2B4	1.61090526311491
Organismal Systems	Nervous system	hsa04730	Long-term depression	21/2452	60/9376	1.33833605220228	PRKG1/GNAI1/ITPR1/PRKCA/LYN/IGF1R/GUCY1A2/PLCB1/PPP2CB/KRAS/GNAI2/GNA13/ITPR2/MAPK1/ARAF/GNA11/RAF1/PLA2G4A/MAP2K2/PPP2R1A/RYR1	1.5645033748502
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	23/2452	67/9376	1.31265369725597	CALM2/CREBBP/ITPR1/PRKCA/CAMK2D/PLCB1/KRAS/CAMK2A/PRKACA/PPP3CB/ITPR2/MAPK1/PRKACB/PPP3CC/RPS6KA3/GRIN2D/RAP1A/ARAF/RAF1/MAP2K2/CACNA1C/PPP3R1/ATF4	1.52832879785856
NA	NA	hsa04517	IgSF CAM signaling	89/2452	299/9376	1.13819310698522	NRP2/PMP22/LMO7/CLMP/SPTBN1/SLIT2/SLIT3/EPB41L2/SSX2IP/PTPRD/CASK/NFASC/ABL1/MYH10/PRKCA/PIK3R1/MAPK14/FGFR1/ANK2/MPDZ/WASL/SPTAN1/FYN/NRP1/LYN/BCAR1/PLXNA4/PLXNA2/MBP/IL1RAPL1/UNC5B/CADM3/AKT2/TJP1/PPFIA1/NLGN4Y/PDPK1/ROBO1/JAM3/PIK3CA/TUBB2A/DOK1/MAGI2/ERC1/PRKCI/MAPK1/ROBO2/ROBO3/SORBS1/ITGA4/RAP1A/NCAM2/MYL9/TUBA3D/CABLES2/NRCAM/RAPGEF2/MSN/PLXNA1/MYLK/TUBA1A/PPFIA4/CABLES1/MAPK10/UNC5C/EPB41L1/PPFIA3/NLGN2/NCK2/MAPK8/MYLK3/CNTNAP1/MAP2K2/LRFN5/AKT3/CADM1/GSK3B/MAG/PLCG1/TRAF6/PIK3R2/NCK1/PLXNA3/PARD6G/PARD3/NLGN4X/SRC/ITGB2/CD84	1.44516737635218
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	26/2452	78/9376	1.27460576400218	PABPC4L/TOB1/XRN1/CNOT4/PFKM/MPHOSPH6/C1D/CNOT6L/CNOT1/DDX6/BTG2/CNOT2/DCP1B/TOB2/EXOSC6/CNOT8/DCP2/DIS3L/DHX36/ENO3/EDC3/ZCCHC7/PABPC5/CNOT3/ENO2/PAN2	1.44920398914745
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	26/2452	78/9376	1.27460576400218	HLA-DRA/IFNGR2/MAPK14/TGFB3/HLA-DPA1/JUN/FOS/TGFB2/HLA-DPB1/HLA-DQA2/HLA-DMA/MAPK1/TAB2/ITGA4/JAK2/FCGR3A/NFKB1/IFNGR1/MAP3K7/HLA-DMB/HLA-DRB1/IRAK4/TRAF6/HLA-DQA1/RELA/ITGB2	1.44920398914745
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	76/2452	254/9376	1.14413430784447	HGF/PDGFRA/FGF7/ATP2B1/ORAI3/CALM2/ADCY3/ADRB3/PDGFC/VEGFA/ITPR1/PDGFA/PRKCA/VEGFC/PDGFRB/GDNF/FGFR1/FGF2/FGFR2/CAMK2D/CYSLTR2/ADCY9/ADORA2B/NFATC4/PTGFR/EDNRB/ORAI1/PTGER1/FGFR4/PLCB1/TBXA2R/MCOLN2/PLCD3/CAMK2A/PRKACA/NFATC3/BDKRB1/ORAI2/NFATC2/PPP3CB/ITPR2/GNA14/CHRM2/P2RX6/ADCY7/PRKACB/FGFR3/PPP3CC/HRH2/SLC8A1/GRIN2D/TPCN1/NOS3/PHKB/RYR2/MST1R/MCOLN1/PLCE1/GNA11/HRC/ASPH/ITPKA/ITPKC/MYLK/P2RX4/ATP2B4/P2RX1/MYLK3/VEGFB/CACNA1C/CACNA1G/PLCG1/PPP3R1/NTRK2/NFATC1/RYR1	1.38581906836734
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	14/2452	38/9376	1.40877479179188	ATP1B1/IRS1/PRKCA/PIK3R1/ATP1A1/HSD11B2/ATP1A2/KRAS/PDPK1/PIK3CA/NR3C2/MAPK1/NEDD4L/PIK3R2	1.5025063323923
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	45/2452	144/9376	1.19494290375204	TNFRSF1A/ALDH9A1/MAPK14/FOXO3/LPIN2/CCND1/FAS/AKT2/IL17RC/SCD5/TRADD/LY96/RIPK1/TCF7L1/CPT1A/ALDH3A2/TAB2/PRKAA1/MAP2K4/LPIN1/C2/MLYCD/NFKB1/CAMKK2/MAP3K7/ADIPOR1/ACADM/PPARA/MAPK10/SIRT1/MAPK8/MAP2K7/IRAK4/ACACB/FADD/AKT3/GSK3B/IKBKG/TRAF6/IKBKB/RELA/TICAM1/CASP3/PRKAB1/SREBF1	1.4028399345878
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	61/2452	201/9376	1.16046196424079	MAF/CCND2/NUPR1/TGFBR2/IGFBP3/RUNX1T1/KLF3/KMT2A/HOXA10/PDGFA/PLAT/MLLT3/HOXA11/IGF1R/MEIS1/JMJD1C/FUS/NCOR1/GADD45B/RARA/POLK/PBX1/LDB1/ATM/RXRB/PBX3/CDKN1A/HOXA9/MYC/CCNT2/MMP9/PML/PLAU/BIRC2/PRCC/ELK4/DDB2/CDKN1B/SIN3A/CEBPB/CDK14/SP1/GADD45G/MAX/ZEB1/NFKB1/ERG/TFE3/CDK9/SLC45A3/BCL2L1/SUPT3H/TCF3/DDIT3/EWSR1/SS18L1/RELA/MLF1/LYL1/BMI1/PAX8	1.36846734311937
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	32/2452	99/9376	1.2359813469112	DES/LAMA2/SGCE/TNNI3/ITGA1/SGCA/SGCB/SGCD/SNTB1/CACNA2D1/ITGA11/SNTB2/ITGB5/TGFB3/SNTA1/MYL3/DMD/TGFB2/CACNB4/LMNA/PRKAA1/SLC8A1/ITGA4/RYR2/CACNB2/EMD/TNNT2/DTNA/CACNA1C/CACNB1/CACNB3/PRKAB1	1.40461996190281
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	138/2452	480/9376	1.09934747145188	WNT2/TNFRSF1A/FZD2/CSF1/CCS/GPX7/CALM2/UBB/WNT2B/WNT5B/GPX8/CAPN2/ITPR1/PRKCA/OPTN/PRNP/SDHD/MAPK14/FZD1/FZD7/CAMK2D/ACTR10/ATXN1/FUS/GPR37/PLCB1/FAS/APC/LRP5/ATXN2L/UQCRC2/RB1CC1/COX7A1/WIPI2/UBA7/KRAS/LRP6/HIP1/IFT57/TUBB2A/CAMK2A/CAT/BDNF/ULK2/PSMC2/FZD4/PINK1/RAB5A/PPP3CB/ITPR2/BCL2/DVL3/DVL2/MAPK1/UQCRB/ATXN2/DLG4/ATXN1L/SIGMAR1/KIF5B/KLC1/UBE2L6/PPP3CC/FZD6/ULK1/PIK3C3/GRIN2D/CSNK2A1/DCTN6/RYR2/NDUFS1/NDUFB5/SPG11/ARAF/TUBA3D/NFKB1/NDUFS4/STX1A/RAF1/TRAP1/DNAL4/ATG14/CASP7/WNT11/PSEN1/DCTN3/HTRA2/NEFM/ATF6/CDK5/PIK3R4/MT-ND4L/CSNK2B/TUBA1A/BCL2L1/WNT3/KLC4/MAPK10/AMBRA1/NDUFB10/PSEN2/CSNK2A2/SQSTM1/MAPK8/NDUFA5/MT-ND3/MAP1LC3B/ATG2B/DKK1/MAP2K7/MFN2/ZFYVE1/WDR41/MAP2K2/CACNA1C/FADD/LRRK2/UBE2J2/GSK3B/DDIT3/DERL1/DCTN4/EIF2AK3/DNAH10/MT-ND2/PLCG1/PSMD6/PPP3R1/APAF1/RELA/DNALI1/HTT/DNAL1/RYR1/ATF4/DCTN1/CASP3/RAB1A	1.32968077986289
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	53/2452	173/9376	1.17145847674188	TNFRSF1A/CCND3/HLA-DRA/CREBBP/CDK6/PRKCA/IFNGR2/PIK3R1/CASP1/CDK4/FAS/AKT2/HLA-DPA1/IFNAR1/SOCS3/PIK3CA/KPNA5/IL18/TRADD/HLA-DPB1/HLA-DQA2/HLA-DMA/CALCOCO2/MAPK1/PML/TLR3/JAK2/RNASEL/NFKB1/ADAR/RAF1/NLRX1/IFNGR1/IFIH1/HNRNPUL1/HLA-DMB/NXT1/RAB11B/HLA-DRB1/MAP2K2/IRAK4/FADD/AKT3/KPNA6/IKBKG/RAE1/PIK3R2/IKBKB/HLA-DQA1/APAF1/RELA/TICAM1/CASP3	1.35451757105525
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	12/2452	32/9376	1.43393148450245	ACSS1/ACSS3/HIBCH/MLYCD/SUCLA2/ACADS/MCEE/DLD/ACACB/ABAT/ECHDC1/SUCLG1	1.4631777147794
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	12/2452	32/9376	1.43393148450245	GABARAPL2/PPP2CB/WIPI2/GABARAPL1/GABARAP/ULK2/PIK3C3/PIK3R4/ATG4D/MLST8/ATG2B/ATG4B	1.4631777147794
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	33/2452	103/9376	1.22510651103122	SLC16A10/COL15A1/COL14A1/DPP4/ATP1B1/COL5A2/MME/COL5A1/COL21A1/COL16A1/COL8A2/COL6A1/COL6A2/COL1A2/COL1A1/COL3A1/ELN/ATP1A1/SLC38A2/CPA1/SLC7A7/SLC1A5/KCNE3/ATP1A2/COL4A5/XPNPEP2/COL6A6/COL11A1/COL5A3/SLC8A1/SLC15A1/COL9A2/COL9A3	1.36698541465992
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	28/2452	86/9376	1.2449637694905	CREB3L1/ATP1B1/ADCY3/PRKCA/GCK/ATP1A1/CAMK2D/ADCY9/VAMP2/PLCB1/ATP1A2/CREB1/CAMK2A/PRKACA/ATF2/ADCY7/PRKACB/ATF6B/KCNMA1/RYR2/ADCY6/CREB3/GNA11/STX1A/PCLO/GIP/CACNA1C/ATF4	1.35803376013981
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	28/2452	86/9376	1.2449637694905	GJA1/DES/LAMA2/SGCE/ITGA1/SGCA/SGCB/SGCD/SNTB1/CACNA2D1/ITGA11/SNTB2/ITGB5/SNTA1/DMD/TCF7L1/CACNB4/LMNA/SLC8A1/ITGA4/RYR2/CACNB2/EMD/DTNA/CACNA1C/ACTN2/CACNB1/CACNB3	1.35803376013981
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	48/2452	156/9376	1.17655916677124	TNFRSF1A/CD81/CDK6/PIK3R1/CDK4/CLDN11/CCND1/FAS/STAT3/PPP2CB/AKT2/PIAS1/KRAS/IFNAR1/SOCS3/PIK3CA/EIF3E/CDKN1A/TRADD/SOS1/MYC/RIPK1/MAPK1/TLR3/CLDN23/RNASEL/ARAF/NFKB1/RAF1/YWHAH/PPP2R2D/PPARA/SOS2/CLDN12/MAP2K2/FADD/AKT3/GSK3B/IKBKG/TRAF6/PIK3R2/PPP2R1A/IKBKB/APAF1/RELA/CLDN15/TICAM1/CASP3	1.3232882333594
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	11/2452	29/9376	1.45041345558868	YAP1/DCHS1/LATS2/FAT4/WTIP/AJUBA/NF2/LATS1/SAV1/RASSF1/TEAD2	1.4455781500011
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	23/2452	69/9376	1.27460576400218	PRKCA/PIK3R1/MAPK14/FYN/LYN/AKT2/KRAS/PDPK1/PIK3CA/SOS1/MAPK1/MAP2K4/RAF1/MAPK10/SOS2/PLA2G4A/MAPK8/MAP2K7/MAP2K2/AKT3/LAT/PLCG1/PIK3R2	1.36237504148266
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	23/2452	69/9376	1.27460576400218	CREB3L1/CALM2/PRKCA/CAMK2D/JUN/CREB1/CAMK2A/PRKACA/FOS/ATF2/PPP3CB/PRKACB/ATF6B/PPP3CC/GRIN2D/CREB3/FOSB/STX1A/MAOA/SIRT1/CACNA1C/PPP3R1/ATF4	1.36237504148266
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	34/2452	107/9376	1.21504474699273	CREB3L1/CALM2/CREBBP/ITPR1/GCK/CAMK2D/PDE3B/PFKM/PLCB1/AKT2/CREB1/CAMK2A/PDHB/PRKACA/ATF2/PPP3CB/SIK2/ITPR2/CPT1A/PRKACB/PPP3CC/PRKAA1/PPP4C/FBP1/PHKB/G6PC3/CREB3/PPARA/SIRT1/ACACB/AKT3/PPP3R1/ATF4/PRKAB1	1.33128680511787
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	27/2452	83/9376	1.24389237209851	EPHX2/PEX2/ABCD4/ACSL3/CAT/PEX6/DHRS4/NUDT7/PEX11B/ACOX2/DECR2/MLYCD/PEX14/HSD17B4/PEX12/HMGCLL1/ABCD3/AMACR/GNPAT/PEX3/ECI2/PEX26/MPV17/PEX10/PEX1/PEX5/HMGCL	1.3280873399958
Human Diseases	Immune disease	hsa05330	Allograft rejection	14/2452	39/9376	1.37265236123311	HLA-B/HLA-A/HLA-DRA/HLA-F/HLA-C/FAS/HLA-E/HLA-DPA1/HLA-DPB1/HLA-DQA2/HLA-DMA/HLA-DMB/HLA-DRB1/HLA-DQA1	1.38771359519992
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	9/2452	23/9376	1.49627633165473	POMGNT2/FKRP/B4GALT2/FUT4/FKTN/B4GALT3/POMGNT1/ST3GAL3/POMT2	1.41801020299651
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	21/2452	63/9376	1.27460576400218	ERCC4/XPA/ERCC1/POLR2C/POLD4/ERCC6/RFC1/POLR2B/DDB2/POLR2J3/POLR2M/POLD2/XPC/POLR2K/GTF2H2/UVSSA/GTF2H1/POLR2G/GTF2H2C/ERCC3/CETN2	1.30137501248344
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	31/2452	98/9376	1.20957485767553	MARCKS/BIN1/CFL2/PRKCA/PIK3R1/LYN/GSN/AKT2/WASF2/ASAP1/PLD1/PIK3CA/MAPK1/RPS6KB1/LIMK1/FCGR3A/ASAP2/RAF1/SCIN/CRK/MYO10/PLA2G4A/DOCK1/AKT3/PIP5K1C/LAT/PLCG1/PIK3R2/PIP5K1A/INPPL1/PRKCD	1.2410588479869
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	30/2452	95/9376	1.20752125010732	CSF1/HLA-DRA/VEGFA/ATP6V0D1/ATP6V1G1/TEK/TNFSF13B/TGFB3/ANGPT1/HLA-DPA1/JUN/FOS/TGFB2/IL18/HLA-DPB1/HLA-DQA2/HLA-DMA/IL11/ATP6V1C1/ATP6AP1/TCIRG1/ATP6V0A1/ATP6V1D/HLA-DMB/HLA-DRB1/ACP5/HLA-DQA1/ITGB2/ATP6V0B/ATP6V0A2	1.20974638431842
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	23/2452	71/9376	1.2387013762838	PDGFRA/GCK/PIK3R1/PDGFRB/FGFR1/FGFR2/GLS/PFKM/SLC1A5/AKT2/KRAS/PIK3CA/PDHB/MYC/PTEN/MAPK1/FGFR3/RAF1/MAP2K2/AKT3/HIF1A/PIK3R2/SIRT3	1.20141555395474
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	51/2452	170/9376	1.14714518760196	GATA4/AMOTL1/MYH10/MPDZ/CDK4/CLDN11/ROCK2/CCND1/ROCK1/PPP2CB/TJP1/STK11/JAM3/ARHGEF2/JUN/PRKACA/LLGL2/DLG3/PRKCI/PRKACB/DLG1/PRKAA1/CLDN23/RAP1A/YBX3/MYL9/MAP3K1/TUBA3D/NF2/RAPGEF2/MSN/MICALL2/TUBA1A/PPP2R2D/AMOTL2/MAPK10/MAPK8/NEDD4L/MAP2K7/CLDN12/SYNPO/NEDD4/TJAP1/PPP2R1A/PARD6G/PARD3/CLDN15/WHAMM/SRC/PRKAB1/SYMPK	1.15213237355046
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	25/2452	78/9376	1.22558246538671	C1R/CFL2/CALM2/GNAI1/CASP1/MAPK14/C1S/JUN/GNAI2/FOS/LY96/SERPING1/MAPK1/C2/NFKB1/CASP7/MAPK10/NOD1/MAPK8/IRAK4/TRAF6/RELA/TICAM1/ITGB2/CASP3	1.19048851690361
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	31/2452	99/9376	1.19735692982023	CALM2/IL1R1/ADCY3/ITPR1/PRKCA/PIK3R1/MAPK14/CAMK2D/ADCY9/PTGER2/PLCB1/PIK3CA/CAMK2A/PRKACA/BDKRB1/TRPV3/ITPR2/TRPV2/ADCY7/PRKACB/KNG1/ADCY6/MAPK10/PLA2G4A/MAPK8/ASIC1/PLCG1/PIK3R2/SRC/PTGER4/PRKCD	1.17471777695063
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	13/2452	37/9376	1.34350337286716	PGM3/GCK/GFPT2/TGDS/NANP/UGDH/GMPPA/GALK1/UAP1L1/PMM2/GALT/GFPT1/GALK2	1.24580199387843
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	9/2452	24/9376	1.43393148450245	EXT1/B3GAT3/EXT2/HS2ST1/XYLT1/B3GALT6/XYLT2/EXTL2/EXTL3	1.26660697536605
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	15/2452	44/9376	1.30357407682041	TAF7/GTF2I/TAF1/TAF6/TAF12/GTF2F1/GTF2F2/GTF2H2/GTF2A1/GTF2H1/GTF2E2/GTF2H2C/TAF8/ERCC3/TAF4	1.2010774069644
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	32/2452	103/9376	1.187982071303	PABPC4L/FUS/PPP2CB/NUDT21/PELO/FIP1L1/RNMT/UPF3A/GSPT2/PPP2R5E/CSTF2T/RNPS1/CPSF7/DDX19A/WDR82/PPP2R2D/NXT1/PCF11/PPP2R3C/DDX39B/PPP2R5B/CSTF1/HBS1L/SMG6/PPP2R1A/PABPC5/PPP2R5A/PAPOLG/CPSF2/CPSF1/WDR33/SYMPK	1.14154294565529
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	28/2452	89/9376	1.20299869860879	GLUL/GABARAPL2/ADCY3/GNAI1/PRKCA/SLC38A2/GNG11/ADCY9/TRAK2/GLS/GABARAPL1/GNAI2/GABARAP/PRKACA/GABBR1/GNB4/ADCY7/PRKACB/ADCY6/GNB3/GNB2/CACNA1C/ABAT/GNGT1/GNG12/KCNJ6/SRC/GPHN	1.1450326638994
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	12/2452	34/9376	1.34958257364936	FBXL3/CRY2/CREB1/CLOCK/FBXW11/PRKAA1/PER1/BTRC/PER3/CRY1/CSNK1D/PRKAB1	1.21516889406466
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	16/2452	48/9376	1.27460576400218	ALDH9A1/ACAA2/AUH/HADHB/IVD/ALDH3A2/HIBCH/ACADS/ACSF3/HMGCLL1/ACADM/MCEE/DLD/ABAT/AACS/HMGCL	1.13501954565801
NA	NA	hsa03272	Virion - Hepatitis viruses	16/2452	48/9376	1.27460576400218	DPP4/CD81/CD63/CD9/CLDN11/IST1/TGOLN2/CHMP1A/LAMP2/CLDN23/VPS4A/LAMP1/CLDN12/PDCD6IP/VPS4B/CLDN15	1.13501954565801
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	110/2452	388/9376	1.08407191268226	WNT2/TNFRSF1A/APOE/MME/FZD2/SLC39A13/CSF1/CALM2/WNT2B/LRP1/WNT5B/IRS1/CAPN2/ITPR1/SDHD/PIK3R1/FZD1/RTN3/FZD7/ADAM10/SLC39A7/PLCB1/FAS/APC/LRP5/UQCRC2/RB1CC1/COX7A1/WIPI2/AKT2/KRAS/LRP6/BACE1/PIK3CA/TUBB2A/SLC39A6/ULK2/RTN4/PSMC2/FZD4/PPP3CB/APH1A/ITPR2/DVL3/DVL2/MAPK1/UQCRB/APBB1/KIF5B/KLC1/PPP3CC/FZD6/SLC11A2/ULK1/PIK3C3/GRIN2D/CSNK2A1/SLC39A4/NDUFS1/LPL/NDUFB5/ARAF/SLC39A9/TUBA3D/NFKB1/NDUFS4/RAF1/ATG14/CASP7/WNT11/PSEN1/ATF6/CDK5/PIK3R4/MT-ND4L/CSNK2B/TUBA1A/WNT3/KLC4/MAPK10/AMBRA1/NDUFB10/PSEN2/CSNK2A2/MAPK8/NDUFA5/MT-ND3/NCSTN/ATG2B/DKK1/MAP2K7/MAP2K2/SLC39A14/CACNA1C/FADD/AKT3/GSK3B/DDIT3/EIF2AK3/IKBKG/MT-ND2/SLC39A2/PIK3R2/PSMD6/PPP3R1/IKBKB/APAF1/RELA/ATF4/CASP3	1.00647409285695
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	18/2452	56/9376	1.22908412957353	CASP1/HSPA1A/ARF1/IL18/CLK4/HSPA1B/NFKB1/CASP7/HSPA6/SAR1B/NFKB2/HBS1L/APAF1/RELA/ITGB2/CASP3/RAB1A/CLK1	1.02317142365111
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	33/2452	110/9376	1.14714518760196	ADCY3/GNAI1/PIK3R1/MAPK14/ADCY9/IGF1R/PDE3B/AKT2/CDC25B/KRAS/GNAI2/PIK3CA/PRKACA/MAPK1/ADCY7/PRKACB/RPS6KA3/CDC16/ANAPC16/ADCY6/ARAF/ANAPC13/RAF1/CDC27/FZR1/ANAPC10/MAPK10/MAPK8/MAD2L2/AKT3/MAD1L1/PIK3R2/CDC23	0.923769457667836
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	12/2452	36/9376	1.27460576400218	GALNT1/ST3GAL2/GALNT10/ST3GAL1/GALNT12/GALNT11/GCNT1/GALNT7/C1GALT1/ST6GALNAC4/GALNT18/C1GALT1C1	0.982324108283833
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	16/2452	50/9376	1.22362153344209	AOC1/CKB/ALDH9A1/P4HA2/OAT/SAT2/ALDH3A2/NOS3/SMOX/MAOA/P4HA1/PYCR1/PYCR2/ALDH18A1/L3HYPDH/P4HA3	0.943448632609712
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	23/2452	75/9376	1.172637302882	CREB3L1/ATP1B1/GPX7/ADCY3/GPX8/ITPR1/PRKCA/ATP1A1/ADCY9/HSP90B1/PLCB1/ATP1A2/CREB1/PRKACA/ATF2/ITPR2/ADCY7/PRKACB/ATF6B/ADCY6/CREB3/ATF4/PAX8	0.893239240103219
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	15/2452	47/9376	1.22036722085315	SOCS1/IRS1/GCK/PIK3R1/SOCS2/SOCS3/PIK3CA/MAPK1/MAPK10/MAPK8/CACNA1C/CACNA1G/PIK3R2/IKBKB/PRKCD	0.901250914842228
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	10/2452	30/9376	1.27460576400218	MTHFR/MTR/ABCC4/NFKB1/SHMT2/IKBKG/ABCC3/IKBKB/RELA/SLC46A1	0.896447229625903
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	14/2452	44/9376	1.21666913836571	HLA-B/HLA-A/HLA-DRA/HLA-F/HLA-C/FAS/HLA-E/HLA-DPA1/HLA-DPB1/HLA-DQA2/HLA-DMA/HLA-DMB/HLA-DRB1/HLA-DQA1	0.857241862029791
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	23/2452	76/9376	1.15720786468619	ATP1B1/CALM2/ADCY3/GNAI1/ITPR1/PRKCA/ATP1A1/SLC4A2/CAMK2D/ADCY9/PLCB1/ATP1A2/GNAI2/CAMK2A/PRKACA/ITPR2/ADCY7/PRKACB/HRH2/ADCY6/MYLK/MYLK3/SLC9A1	0.818854862370235
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	34/2452	116/9376	1.12077403386398	GLUL/ADCY3/GNAI1/ITPR1/PRKCA/SLC38A2/GNG11/ADCY9/GLS/SLC1A3/TRPC1/PLCB1/GNAI2/PLD1/PRKACA/PPP3CB/ITPR2/GNB4/MAPK1/ADCY7/DLG4/PRKACB/PPP3CC/GRIN2D/ADCY6/HOMER3/GNB3/PLA2G4A/GNB2/CACNA1C/NCDN/GNGT1/PPP3R1/GNG12	0.778868993032461
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	46/2452	160/9376	1.09934747145188	HLA-B/VCAM1/HLA-A/SDC2/VCAN/CD99/GLG1/PTPRD/HLA-DRA/NFASC/HLA-F/HLA-C/ALCAM/CLDN11/CADM3/HLA-E/NLGN4Y/JAM3/HLA-DPA1/HLA-DPB1/HLA-DQA2/HLA-DMA/ICOSLG/CD99L2/ITGA4/CLDN23/NCAM2/NEO1/CD58/CD22/NRCAM/HLA-DMB/HLA-DRB1/NLGN2/CNTNAP1/CLDN12/CDH15/PTPRM/CD4/CADM1/MAG/HLA-DQA1/CLDN15/NLGN4X/SDC1/ITGB2	0.754245830269371
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	4/2452	10/9376	1.52952691680261	SELENBP1/PAPSS2/TST/BPNT1	0.99696131275302
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	7/2452	20/9376	1.33833605220228	CYB5R3/TGDS/NANP/CYB5R2/UGDH/GMPPA/UAP1L1	0.901333494735897
Human Diseases	Substance dependence	hsa05032	Morphine addiction	27/2452	91/9376	1.13453919652941	ADCY3/GNAI1/PRKCA/PDE3A/GNG11/ADCY9/PDE3B/PDE4A/GNAI2/PRKACA/GABBR1/GNB4/PDE7B/ADCY7/PRKACB/ADCY6/GRK5/ARRB1/GNB3/ADORA1/KCNJ5/PDE4B/GNB2/GNGT1/PDE8B/GNG12/KCNJ6	0.767442618702586
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	11/2452	34/9376	1.23711735917858	POLR2C/POLR3GL/POLR3D/POLR2B/POLR2J3/POLR2M/CRCP/POLR3E/POLR2K/POLR2G/POLR3A	0.824233416753714
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	6/2452	17/9376	1.34958257364936	FMO1/GGT5/CSAD/ADO/GGT7/FMO4	0.858473421603012
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	6/2452	17/9376	1.34958257364936	NRP2/PCDH7/MYH10/TFRC/LAMP2/LAMP1	0.858473421603012
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	14/2452	45/9376	1.18963204640203	HLA-B/HLA-A/HLA-DRA/HLA-F/HLA-C/FAS/HLA-E/HLA-DPA1/HLA-DPB1/HLA-DQA2/HLA-DMA/HLA-DMB/HLA-DRB1/HLA-DQA1	0.75878936522908
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	12/2452	38/9376	1.20752125010732	ENPP1/NNMT/NADK2/QPRT/BST1/NNT/SIRT2/SARM1/SIRT1/NT5C2/NMNAT1/SIRT3	0.762772065824865
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	10/2452	31/9376	1.23348944903436	SEC62/TMEM208/SEC63/SPCS1/OXA1L/SEC61A1/SRP54/SEC61A2/IMMP2L/SGTA	0.774864556316485
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	13/2452	42/9376	1.18356249514488	SLC40A1/FTL/PRNP/TFRC/ACSL3/SAT2/GCLM/SLC11A2/LPCAT3/MAP1LC3B/SLC39A14/SLC7A11/STEAP3	0.709483076920782
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	29/2452	100/9376	1.10890701468189	CD36/MME/CSF1/EPOR/ITGA1/CD7/IL11RA/IL1R1/HLA-DRA/KITLG/IL6R/CD44/CD9/TFRC/IL4R/ANPEP/HLA-DPA1/HLA-DPB1/HLA-DQA2/HLA-DMA/IL11/ITGA4/FLT3LG/CD22/HLA-DMB/HLA-DRB1/CD19/CD4/HLA-DQA1	0.651542612673039
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	9/2452	28/9376	1.22908412957353	B4GALT4/B3GALT2/B3GALNT1/B4GALT2/FUT4/ST3GAL4/B4GALT3/ST3GAL3/A4GALT	0.722407104905788
NA	NA	hsa04081	Hormone signaling	61/2452	219/9376	1.06508152882374	PRLR/SLC16A10/SLC40A1/IGF2/EPOR/ADCY3/IRS1/ADRB3/PRKG1/GNAI1/SMAD5/THRA/PIK3R1/GNG11/PTH1R/ADCY9/IGF1R/BMPR1A/PLCB1/STAT3/SMAD4/APPL1/SSTR1/STK11/GNAI2/PIK3CA/PRKACA/ADRA2A/NPR2/GNA13/RAMP2/SMAD9/GNB4/GNA14/ADCY7/PRKACB/ACVR1/CSH2/JAK2/ADCY6/GHR/GNA11/CSH1/ADIPOR1/GIP/STAT5A/VIPR2/GNB3/HAMP/POMC/DRD4/UCN/GPER1/GNB2/STAT5B/GNGT1/PIK3R2/OPRL1/MC1R/GNG12/SRC	0.579923273477045
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	38/2452	134/9376	1.08436609773319	CALD1/CALM2/ADCY3/PRKG1/MYH10/ITPR1/PRKCA/ADCY9/GUCY1A2/ADORA2B/ROCK2/PTGIR/ROCK1/PLCB1/PRKACA/NPR2/GNA13/RAMP2/ITPR2/MAPK1/ARHGEF12/ADCY7/PRKACB/ARHGEF11/KCNMA1/ADCY6/MYL9/PPP1R12B/ARAF/GNA11/PPP1R12A/RAF1/MYLK/PLA2G4A/MYLK3/MAP2K2/CACNA1C/PRKCD	0.585335305799753
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	63/2452	227/9376	1.06123563610754	HGF/GSTT1/ABL1/VEGFA/SDHD/PIK3R1/AHR/MAPK14/FOXO3/GSTM3/UQCRC2/COX7A1/EPHX2/AKT2/KRAS/PDPK1/JUN/PLD1/EPHX1/PIK3CA/CAT/FOS/SOS1/PTPRJ/PRKD2/PTEN/MAPK1/PRKD1/UQCRB/KEAP1/PTPN1/MAP2K4/NFE2L2/NDUFS1/NDUFB5/ARAF/NFKB1/NDUFS4/RAF1/AKR1C1/AKR1A1/MT-ND4L/SLC26A2/MAPK10/SOS2/NDUFB10/MAPK8/NDUFA5/MT-ND3/MAP2K7/GSTM2/MGST2/MAP2K2/NQO1/AKT3/HIF1A/IKBKG/MT-ND2/PIK3R2/IKBKB/RELA/SRC/PRKCD	0.555773314061687
Organismal Systems	Digestive system	hsa04978	Mineral absorption	18/2452	61/9376	1.12833952878881	SLC40A1/ATP1B1/FTL/ATP2B1/CYBRD1/ATP1A1/ATP1A2/VDR/TRPM7/CLCN2/SLC11A2/SLC8A1/SLC31A1/SLC39A4/ATP2B4/ATP7A/HMOX2/SLC46A1	0.598413344731321
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	27/2452	94/9376	1.09833049876783	MAPK14/HSP90B1/IL17RC/JUN/FOS/TRADD/MAPK7/MMP9/JUND/MAPK1/TAB2/CEBPB/NFKB1/FOSB/MAP3K7/MAPK10/MAPK8/FADD/IL17RE/GSK3B/IKBKG/TRAF6/IKBKB/RELA/TRAF5/CASP3/SRSF1	0.570162602790056
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	21/2452	72/9376	1.1152800435019	MAPK14/CYLD/TBKBP1/TRADD/RIPK1/ZNFX1/AZI2/MAP3K1/NFKB1/PIN1/ADAR/NLRX1/IFIH1/MAP3K7/MAPK10/MAPK8/FADD/IKBKG/TRAF6/IKBKB/RELA	0.584322851074485
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	7/2452	22/9376	1.21666913836571	AOC1/ALDH9A1/ALDH3B1/ASPA/HNMT/ALDH3A2/MAOA	0.605448287870605
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	29/2452	103/9376	1.07660875211834	LAMA2/LAMB2/LAMC3/COL1A2/COL1A1/COL3A1/IL1R1/PRKCA/PIK3R1/FN1/TGFB3/PLCB1/COL4A5/LAMB1/PIK3CA/PRKACA/LAMC1/TGFB2/RAB5A/HSPB1/GNA14/PRKACB/NFKB1/GNA11/RAB7A/PIK3R2/RELA/ITGB2/CASP3	0.465215538641388
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	17/2452	59/9376	1.10177786379849	ENPP1/NME4/NME3/DCTD/TK2/ENTPD4/UCK1/ASMTL/TYMP/NME7/NT5C2/CANT1/RRM2B/NT5C3B/NT5C3A/AK9/CDADC1	0.466668654489339
Organismal Systems	Digestive system	hsa04970	Salivary secretion	26/2452	93/9376	1.06902418916311	ATP1B1/ATP2B1/CALM2/ADCY3/ADRB3/PRKG1/LYZ/ITPR1/PRKCA/ATP1A1/SLC4A2/ADCY9/VAMP2/GUCY1A2/PLCB1/ATP1A2/PRKACA/BST1/ITPR2/ADCY7/PRKACB/KCNMA1/ADCY6/SLC12A2/ATP2B4/SLC9A1	0.398075962816271
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	30/2452	109/9376	1.05242677761647	SPP1/PIK3R1/MAPK14/AKT2/JUN/IFNAR1/PIK3CA/FOS/LY96/RIPK1/MAPK1/TAB2/MAP2K4/TLR3/NFKB1/MAP3K7/CXCL9/MAPK10/MAPK8/MAP2K7/MAP2K2/IRAK4/FADD/AKT3/IKBKG/TRAF6/PIK3R2/IKBKB/RELA/TICAM1	0.327615298673076
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	9/2452	31/9376	1.11014050413093	ALDH9A1/ALDH3B1/CSAD/ALDH3A2/HIBCH/MLYCD/ACADS/SMOX/ABAT	0.365515329360018
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	9/2452	31/9376	1.11014050413093	GLUL/ACSS1/CAT/HYI/AFMID/GRHPR/MCEE/DLD/SHMT2	0.365515329360018
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	6/2452	20/9376	1.14714518760196	CYP24A1/SOAT1/LIPA/LSS/SC5D/CYP2R1	0.391997498674918
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	18/2452	65/9376	1.05890325009411	AGPAT4/ALDH9A1/AGPAT2/LPIN2/MBOAT2/GPAT2/AGPAT3/GLA/ALDH3A2/LPIN1/LPL/AKR1A1/AGPAT1/DGKQ/DGKH/DGKE/DGKD/PNPLA2	0.2835731548853
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	14/2452	50/9376	1.07066884176183	HLA-DRA/LTBR/TNFSF13B/HLA-DPA1/HLA-DPB1/HLA-DQA2/HLA-DMA/ICOSLG/ITGA4/HLA-DMB/CCL28/HLA-DRB1/HLA-DQA1/CCR10	0.298148488216025
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	14/2452	50/9376	1.07066884176183	HGF/CD36/VCAM1/SDC2/CD81/LRP1/THBS1/TGFB3/GYPC/TGFB2/IL18/THBS3/SDC1/ITGB2	0.298148488216025
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	15/2452	54/9376	1.06217147000181	HES1/POLK/ERCC4/ERCC1/WDR48/REV3L/REV1/TELO2/FAN1/PALB2/POLI/ATR/POLH/RMI2/FANCL	0.272647053247081
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	8/2452	28/9376	1.09251922628758	ELOVL2/ACAA2/HADHB/PPT1/ACOT2/THEM4/MBLAC2/ELOVL3	0.291755463527566
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	23/2452	85/9376	1.03467997313118	ENPP1/NME4/NME3/IMPDH1/DCTD/AMPD2/TK2/AK1/ENTPD2/ENTPD4/LACC1/UCK1/ASMTL/TYMP/NME7/NT5C2/CANT1/HPRT1/RRM2B/NT5C3B/NT5C3A/AK9/GMPR2	0.191128005009833
Human Diseases	Immune disease	hsa05310	Asthma	9/2452	32/9376	1.07544861337684	HLA-DRA/PRG2/HLA-DPA1/HLA-DPB1/HLA-DQA2/HLA-DMA/HLA-DMB/HLA-DRB1/HLA-DQA1	0.254405899656192
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	5/2452	17/9376	1.1246521447078	CYP27A1/ACOX2/HSD17B4/AMACR/CYP46A1	0.306109518161491
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	6/2452	21/9376	1.09251922628758	ENPP1/CSAD/AASDHPPT/PANK3/ALDH3A2/PANK1	0.252573094498273
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	12/2452	44/9376	1.04285926145633	MPG/PARG/POLD4/RFC1/OGG1/NTHL1/POLD2/PARP3/XRCC1/MBD4/POLL/APTX	0.169570772160581
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	54/2452	205/9376	1.00724943301635	CD36/TGFBR2/TGFBR1/TNNI3/COL1A2/COL1A1/COL3A1/PDK4/CTSD/IRS1/PRKCA/SDHD/PIK3R1/MAPK14/SMAD3/CAMK2D/GFPT2/TGFB3/PLCB1/UQCRC2/COX7A1/AKT2/PDK2/PIK3CA/CAMK2A/PDHB/TGFB2/MMP2/MMP9/PTEN/UQCRB/NOS3/SP1/RYR2/NDUFS1/NDUFB5/MPC2/NFKB1/NDUFS4/MT-ND4L/PPARA/MAPK10/NDUFB10/MAPK8/NDUFA5/MT-ND3/AKT3/GSK3B/MT-ND2/PIK3R2/MPC1/GFPT1/RELA/PRKCD	0.062451081935946
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	38/2452	144/9376	1.00906289650172	RBPJ/VLDLR/ITPR1/PRKCA/PIK3R1/ATXN10/ATXN1/PLCB1/ATXN2L/RB1CC1/WIPI2/AKT2/PIK3CA/ULK2/CIC/PSMC2/ITPR2/PUM2/ATXN2/ATXN1L/ULK1/PIK3C3/GRIN2D/SP1/MYOD1/ATG14/PIK3R4/KAT5/MAPK10/AMBRA1/MAPK8/ATG2B/OMA1/AKT3/PIK3R2/PSMD6/OPA1/RYR1	0.0652180350807903
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	21/2452	79/9376	1.01645776116629	SLC18A3/AP2M1/STX2/ATP6V0D1/ATP6V1G1/VAMP2/SLC1A3/CLTC/AP2A1/SLC6A2/DNM1/ATP6V1C1/NAPA/STX1A/TCIRG1/AP2B1/ATP6V0A1/ATP6V1D/STXBP1/ATP6V0B/ATP6V0A2	0.0874138457383861
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	22/2452	83/9376	1.01354193282101	IFI16/CASP1/AIM2/ZCCHC3/ZDHHC1/POLR3GL/POLR3D/IL18/RIPK1/NFKB1/ADAR/TREX1/CASP7/POLR3E/POLR2K/SAMHD1/FADD/IKBKG/IKBKB/RELA/CASP3/POLR3A	0.07374100872408
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	5/2452	18/9376	1.06217147000181	THAP11/LMBRD1/ABCD4/MTR/MMADHC	0.157109776110624
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	41/2452	157/9376	0.99857649026922	TNFRSF1A/IRS1/IL6R/SDHD/PIK3R1/MAPK14/MLXIP/FAS/UQCRC2/COX7A1/AKT2/JUN/SOCS3/PIK3CA/FOS/UQCRB/PRKAA1/NDUFS1/NDUFB5/BCL2L11/NFKB1/NDUFS4/CASP7/ADIPOR1/PPARA/MAPK10/NDUFB10/MAPK8/NDUFA5/GSK3A/AKT3/GSK3B/DDIT3/EIF2AK3/PIK3R2/IKBKB/RELA/ATF4/CASP3/PRKAB1/SREBF1	-0.0107037436766723
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	36/2452	138/9376	0.997517554436485	CALM2/ADCY3/ITPR1/MAPK14/CAMK2D/ADCY9/IGF1R/PPP2CB/CAMK2A/PRKACA/PPP3CB/ITPR2/MAPK1/PPP2R5E/ADCY7/PRKACB/FBXW11/PPP3CC/RPS6KA3/CDC16/ANAPC16/SLK/ADCY6/ANAPC13/CDC27/YWHAH/BTRC/ANAPC10/MAD2L2/PPP2R5B/MAD1L1/PPP2R1A/PPP3R1/PPP2R5A/CDC23/SMC3	-0.0174822626048725
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	11/2452	42/9376	1.00147595743028	INMT/AOC1/ALDH9A1/HAAO/TDO2/CAT/ALDH3A2/AFMID/MAOA/DLD/DLST	0.00570468830363725
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	14/2452	54/9376	0.991360038668358	HLA-B/HLA-A/HLA-DRA/HLA-F/HLA-C/FAS/HLA-E/HLA-DPA1/HLA-DPB1/HLA-DQA2/HLA-DMA/HLA-DMB/HLA-DRB1/HLA-DQA1	-0.0378897265445408
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	33/2452	128/9376	0.985827895595432	ENPP1/PAPSS2/NME4/NME3/ADCY3/PDE3A/ADCY9/PDE3B/GUCY1A2/NUDT9/IMPDH1/AMPD2/PDE4A/NPR2/AK1/PDE7B/ADCY7/ENTPD2/ENTPD4/ADCY6/LACC1/PDE6B/NME7/PDE9A/NT5C2/CANT1/PDE4B/HPRT1/RRM2B/PDE8B/AK9/GMPR2/PRPS1	-0.0960688869219645
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	6/2452	23/9376	0.997517554436485	MLH3/POLD4/RFC1/MSH6/POLD2/MSH3	-0.00709309091108711
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	6/2452	23/9376	0.997517554436485	MME/ENPEP/CTSA/ANPEP/ATP6AP2/LNPEP	-0.00709309091108711
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	7/2452	27/9376	0.991360038668358	ELOVL2/SCD5/FADS2/FADS1/HSD17B4/ACOT2/ELOVL3	-0.0267533667104557
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	20/2452	78/9376	0.980465972309365	PIK3R1/WASL/FN1/BCAR1/SHC2/CLTC/WASF2/PIK3CA/CAV2/DNM1/GAB1/SHC1/ELMO1/ILK/CRK/ELMO2/DOCK1/MAD2L2/PIK3R2/SRC	-0.103088844315591
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	12/2452	47/9376	0.976293776682517	ALDH9A1/ACSS1/PDHB/ALDH3A2/ME3/ACYP2/GRHPR/AKR1A1/ME2/DLD/ACACB/HAGH	-0.0969529650082282
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	34/2452	133/9376	0.977517202467834	HLA-B/HLA-A/PRKCA/IFNGR2/PIK3R1/HLA-C/SH3BP2/FYN/SHC2/FAS/HLA-E/KRAS/IFNAR1/PIK3CA/SOS1/NFATC2/PPP3CB/MAPK1/PPP3CC/SHC1/FCGR3A/ARAF/RAF1/IFNGR1/SOS2/MAP2K2/LAT/PLCG1/PIK3R2/PPP3R1/MICA/NFATC1/ITGB2/CASP3	-0.155394997911169
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	8/2452	32/9376	0.955954323001631	GCK/PFKM/GLA/B4GALT2/G6PC3/GLB1/GALK1/GALT	-0.148518038718209
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	7/2452	28/9376	0.955954323001631	ATP6V0D1/ATP6V1G1/ATP6V1C1/TCIRG1/ATP6V0A1/ATP6V1D/ATP6V0A2	-0.138896177850655
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	12/2452	48/9376	0.955954323001631	ATP1B1/PIK3R1/ATP1A1/PLCB1/AKT2/ATP1A2/PIK3CA/G6PC3/TAS1R3/SLC37A4/AKT3/PIK3R2	-0.182052639996632
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	22/2452	88/9376	0.955954323001631	F3/CLU/F10/VTN/CFD/SERPINE2/C7/C1R/PROS1/PLAT/C1S/PLAUR/CFH/BDKRB1/SERPING1/PLAU/CD46/KNG1/C2/SERPINE1/SERPIND1/ITGB2	-0.247030662944755
Cellular Processes	Cell motility	hsa04814	Motor proteins	49/2452	194/9376	0.965809522207834	TNNT1/TNNI3/TNNT3/DYNLT3/MYH10/MYO9A/ACTR10/KIF1B/MYO1D/DYNC1LI2/MYO1C/DYNC2H1/MYL3/CAPZA2/TUBB2A/KIF26A/KIFAP3/KIF26B/KIFC3/KIF5B/KIF3B/STARD9/KLC1/HOOK3/DCTN6/KIF13A/MYO15B/MYL9/TUBG2/TUBA3D/DYNC2LI1/DNAL4/DYNC1H1/DCTN3/TUBA1A/TNNT2/KLC4/MYO10/KIF7/DYNLRB1/MYO5A/TUBD1/DYNLT1/DCTN4/DNAH10/DNALI1/DNAL1/DCTN1/TUBE1	-0.286354974589119
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	3/2452	12/9376	0.955954323001631	CD46/NCAM2/NPC1	-0.0908511756607517
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	29/2452	116/9376	0.955954323001631	VCAM1/CD99/ARHGAP5/GNAI1/PRKCA/PIK3R1/MAPK14/BCAR1/CLDN11/ARHGAP35/ROCK2/ROCK1/JAM3/GNAI2/PIK3CA/MMP2/MMP9/RASSF5/CD99L2/ITGA4/CLDN23/RAP1A/MYL9/MSN/CLDN12/PLCG1/PIK3R2/CLDN15/ITGB2	-0.284049567556785
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	14/2452	57/9376	0.939183194527918	ELOVL2/ACAA2/SCD5/ACSL3/HADHB/PPT1/CPT1A/FADS2/FADS1/ACADS/HSD17B4/ACSF3/ACADM/ELOVL3	-0.274058778483207
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	42/2452	168/9376	0.955954323001631	GLUL/TNFRSF1A/FTL/CAPN2/IFNGR2/CASP1/CAMK2D/SMPD1/FAS/STAT3/STAT6/IFNAR1/CYLD/CAMK2A/TRADD/JAK3/RIPK1/BCL2/CHMP1A/BIRC2/TRPM7/RBCK1/SHARPIN/TLR3/JAK2/VPS4A/CHMP5/IFNGR1/XIAP/STAT5A/SPATA2L/MAPK10/PLA2G4A/SQSTM1/MAPK8/FADD/STAT5B/CHMP6/USP21/VPS4B/TICAM1/TRAF5	-0.342801423523391
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	93/2452	368/9376	0.966345130860345	TNFRSF1A/CCS/GPX7/GPX8/PFN2/OPTN/SDHD/CASP1/MAPK14/ACTR10/FUS/ANXA11/ATXN2L/TPR/UQCRC2/RB1CC1/COX7A1/WIPI2/TUBB2A/CAT/ULK2/PSMC2/PINK1/RAB5A/PPP3CB/BCL2/ANG/UQCRB/ATXN2/NRG2/SIGMAR1/KIF5B/SETX/KLC1/MATR3/PPP3CC/ULK1/PIK3C3/GRIN2D/DCTN6/UBQLN2/SEC13/POM121/NDUFS1/NDUFB5/SPG11/POM121C/TUBA3D/NDUFS4/DNAL4/ATG14/DCTN3/NEFM/ATF6/PIK3R4/MT-ND4L/NUP93/NUP35/TUBA1A/NXT1/BCL2L1/KLC4/AMBRA1/NDUFB10/SQSTM1/NDUFA5/MT-ND3/MAP1LC3B/ATG2B/NUP133/WDR41/UBQLN4/RANBP2/NUP54/NUP188/DDIT3/DERL1/DCTN4/EIF2AK3/DNAH10/MT-ND2/RAE1/PSMD6/PPP3R1/NUP214/APAF1/DNALI1/DNAL1/ATF4/DCTN1/CASP3/RAB1A/NUP153	-0.391944855386669
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	4/2452	17/9376	0.899721715766241	PAPSS2/INMT/MTR/SEPHS2	-0.246254385280029
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	3/2452	13/9376	0.882419375078429	RAD50/LIG4/POLL	-0.252445288715659
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	21/2452	87/9376	0.922990380829161	ATP1B1/TNNI3/ATP1A1/CACNA2D1/UQCRC2/COX7A1/ATP1A2/MYL3/UQCRB/CACNB4/SLC8A1/RYR2/HRC/ASPH/CACNB2/TNNT2/CACNA1C/SLC9A1/SLC9A6/CACNB1/CACNB3	-0.429425136238388
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	14/2452	59/9376	0.907346476069345	GPX7/GSTT1/GPX8/GSTM3/ANPEP/GGT5/GCLM/LANCL1/GGT7/TXNDC12/GSTM2/MGST2/RRM2B/PGD	-0.424832018797549
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	10/2452	43/9376	0.889259835350355	ALDH9A1/ACAA2/ACSL3/HADHB/CPT1A/ALDH3A2/ACADS/CYP2U1/ACADM/ECI2	-0.433107895852724
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	28/2452	116/9376	0.922990380829161	PHGDH/ACSS1/GCK/SDHD/H6PD/PFKM/ESD/PDHB/CAT/ADPGK/HIBCH/FBP1/ME3/SDS/SUCLA2/ACADS/ME2/CPS1/MCEE/DLD/SHMT2/PGD/ENO3/DLST/SUCLG1/SDSL/ENO2/PRPS1	-0.496633279674634
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	9/2452	39/9376	0.882419375078429	AHCYL1/MTHFR/MTR/MAT2B/MTHFS/ALDH1L2/DLD/SHMT2/SARDH	-0.437856427893925
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	18/2452	76/9376	0.905640937580493	CD36/ANGPTL4/PLTP/CYP27A1/PDPK1/SCD5/RXRB/ACSL3/CPT1A/ME3/SORBS1/ACOX2/LPL/FADS2/ILK/OLR1/ACADM/PPARA	-0.491491804339098
NA	NA	hsa04981	Folate transport and metabolism	7/2452	31/9376	0.863442614324054	MTHFR/MTR/ABCC4/MTHFS/SHMT2/ABCC3/SLC46A1	-0.453183124552914
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	12/2452	52/9376	0.882419375078429	HSD17B2/HSD3B2/ADCY3/ADCY9/IGF1R/PRKACA/BMP6/ADCY7/PRKACB/ADCY6/PLA2G4A/ACOT2	-0.505945392161925
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	5/2452	23/9376	0.831264628697071	ATP1B1/ATP1A1/GLS/ATP1A2/AQP1	-0.482127522213618
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	57/2452	235/9376	0.927479087848391	CREB3L1/ADCY3/ADRB3/PRKG1/TSC2/SDHD/MAPK14/FGFR1/ADCY9/SMARCD3/FRS2/UQCRC2/COX7A1/KRAS/CREB1/SMARCC2/ACSL3/PRKACA/ATF2/SOS1/CPT1A/UQCRB/ADCY7/PRKACB/ARID1B/RPS6KA3/PRKAA1/RPS6KB1/LIPE/SLC25A20/NDUFS1/ADCY6/SMARCE1/CREB3/NDUFB5/NDUFAF3/NDUFS4/RHEB/MT-ND4L/TSC1/COA5/SOS2/NDUFB10/MLST8/NDUFA5/MT-ND3/ARID1A/SMARCD2/AKT1S1/KDM3A/KDM3B/MT-ND2/COX18/SLC25A29/ZNF516/PRKAB1/PNPLA2	-0.669989005657362
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	27/2452	115/9376	0.897765798992836	GNAI1/ITPR1/PRKCA/GNG11/TRPC1/PLCB1/KRAS/GNAI2/PRKACA/ITPR2/GNB4/MAPK1/PRKACB/KCND2/ARAF/RAF1/MAOA/GNB3/KCNJ5/PLA2G4A/GNB2/CACNA1C/GNGT1/PTGS1/GNG12/KCNJ6/CASP3	-0.656422602726919
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	10/2452	45/9376	0.84973717600145	ABCA1/ABCA8/ABCD4/ABCC4/ABCA2/ABCD3/ABCA5/ABCC3/ABCB7/ABCC9	-0.601258252508992
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	12/2452	54/9376	0.84973717600145	PHGDH/AHCYL1/TST/MTR/MAT2B/GCLM/SDS/APIP/DNMT3A/LACC1/SDSL/CISD1	-0.658963286127785
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	15/2452	67/9376	0.856078498210416	ALDH9A1/ACSS1/GCK/ALDH3B1/MINPP1/PFKM/PDHB/ADPGK/ALDH3A2/FBP1/G6PC3/AKR1A1/DLD/ENO3/ENO2	-0.703523987550964
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	8/2452	38/9376	0.805014166738216	ORAI1/JAK3/RFXAP/RFXANK/RFX5/CD19/CD4/IKBKG	-0.71669646731
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	23/2452	102/9376	0.862233310942648	ATP1B1/ATP2B1/ADCY3/ITPR1/PRKCA/ATP1A1/SLC4A2/ADCY9/CPA1/TRPC1/PLCB1/ATP1A2/BST1/ITPR2/ADCY7/KCNMA1/RAP1A/RYR2/ADCY6/RAB3D/SLC12A2/ATP2B4/SLC9A1	-0.832488231435987
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	6/2452	30/9376	0.764763458401305	SDHD/PDHB/SUCLA2/DLD/DLST/SUCLG1	-0.767926874329041
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	77/2452	323/9376	0.911560159394744	PDGFRA/CCND2/ZEB2/MARCKS/TIMP3/VIM/SOCS1/IRS1/NOTCH2/CREBBP/FSCN1/ABL1/VEGFA/CDK6/PDGFA/PRKCA/PIK3R1/PDGFRB/UBE2I/CD44/BMPR2/THBS1/CYP24A1/GLS/MMP16/EFNA5/DICER1/ZFPM2/CCND1/ROCK1/STAT3/APC/CDC25B/KRAS/PIK3CA/TNXB/ATM/CDKN1A/TGFB2/SOS1/MAPK7/MYC/DDIT4/RECK/MMP9/BCL2/PTEN/MAPK1/PLAU/FGFR3/BCL2L2/EFNA2/SHC1/CDKN1B/BCL2L11/IGF2BP1/ZEB1/MDM4/NFKB1/RAF1/DNMT3A/SLC45A3/BMF/CRK/HDAC4/WNT3/SOS2/SIRT1/MIR145/MAP2K2/PLCG1/PIK3R2/IKBKB/CCNG1/RASSF1/CASP3/BMI1	-0.962543340624183
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	34/2452	149/9376	0.872548912269945	ADCY3/GNAI1/ITPR1/PRKCA/MAPK14/GNG11/ADCY9/PLCB1/GNAI2/PRKACA/ITPR2/GNB4/MAPK1/ADCY7/PRKACB/NAPEPLD/NDUFS1/ADCY6/NDUFB5/NDUFS4/MT-ND4L/GNB3/MAPK10/NDUFB10/KCNJ5/MAPK8/NDUFA5/MT-ND3/GNB2/CACNA1C/MT-ND2/GNGT1/GNG12/KCNJ6	-0.933197919138207
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	5/2452	26/9376	0.735349479232024	LMBRD1/SLC19A3/ABCD4/BTD/SLC46A1	-0.804120183306223
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	73/2452	308/9376	0.906294358170378	CREB3L1/GPX7/GPX8/CREBBP/AP2M1/ITPR1/SDHD/ACTR10/SLC1A3/PLCB1/UQCRC2/RB1CC1/COX7A1/WIPI2/CLTC/POLR2C/HIP1/IFT57/CREB1/TUBB2A/BDNF/ULK2/AP2A1/PSMC2/UQCRB/DLG4/KIF5B/KLC1/POLR2B/POLR2J3/ULK1/PIK3C3/DCTN6/SIN3A/SP1/NDUFS1/BBC3/CREB3/NDUFB5/TUBA3D/NDUFS4/STX1A/DNAL4/ATG14/DCTN3/AP2B1/REST/PIK3R4/MT-ND4L/POLR2K/TUBA1A/KLC4/MAPK10/AMBRA1/NDUFB10/POLR2G/MAPK8/NDUFA5/MT-ND3/ATG2B/MAP2K7/DCTN4/DNAH10/MT-ND2/PSMD6/APAF1/DNALI1/HTT/NRF1/DNAL1/DCTN1/CASP3/TAF4	-0.995067824869047
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	35/2452	154/9376	0.869049384546938	NME4/NME3/HSD17B6/GGCX/HAAO/GUSB/NADK2/UROD/TDO2/QPRT/VKORC1L1/RDH11/PANK3/MAT2B/ALDH3A2/AK1/COQ7/GCLM/AFMID/MOCS2/AKR1A1/EARS2/UGDH/COQ5/GMPPA/NME7/DLD/COQ4/SHMT2/NMNAT1/PMM2/NQO1/AK9/PANK1/GPHN	-0.975040571058636
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	3/2452	17/9376	0.674791286824681	GLUL/CPS1/CA14	-0.79861828872155
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	5/2452	27/9376	0.708114313334542	ACADS/HMGCLL1/ABAT/AACS/HMGCL	-0.903814787260225
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	8/2452	41/9376	0.746110691123224	PHGDH/SDS/GRHPR/MAOA/DLD/SHMT2/SARDH/SDSL	-0.969497117381023
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	8/2452	41/9376	0.746110691123224	POLD4/ATM/RAD50/POLD2/UIMC1/NBN/PALB2/RAD51B	-0.969497117381023
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	7/2452	37/9376	0.723424893082316	GLUL/GLS/GFPT2/ASPA/CPS1/ABAT/GFPT1	-1.00306968394293
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	7/2452	37/9376	0.723424893082316	VCAM1/APOL1/PRKCA/PLCB1/FAS/IL18/KNG1	-1.00306968394293
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	3/2452	18/9376	0.637302882001088	ACSL3/ACSF3/ACACB	-0.916550034977725
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	4/2452	23/9376	0.665011702957657	GLUL/GLS/NOS3/CPS1	-0.957161953516149
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	10/2452	51/9376	0.749768096471868	ENPP2/PLD3/LPCAT2/CHPT1/CEPT1/PLD1/PAFAH1B1/TMEM86A/PLA2G4A/TMEM86B	-1.06627858985783
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	3/2452	19/9376	0.603760625053662	PDHB/DLD/DLST	-1.02880592598496
Organismal Systems	Sensory system	hsa04744	Phototransduction	5/2452	29/9376	0.659278843449401	CALM2/RCVRN/RGS9/PDE6B/GNGT1	-1.09352652111361
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	15/2452	75/9376	0.764763458401305	GLUL/PHGDH/PFKM/MTR/MAT2B/SDS/PYCR1/CPS1/SHMT2/PYCR2/ALDH18A1/ENO3/SDSL/ENO2/PRPS1	-1.21713271786775
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	62/2452	275/9376	0.862096989470562	CREB3L1/C7/ITPR1/PRNP/SDHD/PIK3R1/MAPK14/FYN/UQCRC2/COX7A1/HSPA1A/CREB1/PIK3CA/TUBB2A/PRKACA/LAMC1/ATF2/CAV2/PSMC2/PPP3CB/ITPR2/MAPK1/UQCRB/PRKACB/ATF6B/KIF5B/KLC1/PPP3CC/GRIN2D/CSNK2A1/NCAM2/RYR2/NDUFS1/CREB3/NDUFB5/HSPA1B/TUBA3D/NDUFS4/MT-ND4L/CSNK2B/TUBA1A/KLC4/MAPK10/NDUFB10/CSNK2A2/MAPK8/NDUFA5/MT-ND3/HSPA6/CACNA1C/GSK3B/DDIT3/EIF2AK3/MT-ND2/PIK3R2/PSMD6/PPP3R1/APAF1/RYR1/ATF4/CASP3/PRKCD	-1.3812200643402
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	60/2452	268/9376	0.856078498210416	SLC39A13/CALM2/UBB/GNAI1/ITPR1/SDHD/CAMK2D/GPR37/SLC39A7/UQCRC2/COX7A1/UBA7/GNAI2/TUBB2A/CAMK2A/PRKACA/SLC39A6/PSMC2/PINK1/ITPR2/UQCRB/KEAP1/PRKACB/KIF5B/KLC1/UBE2L6/SLC11A2/NFE2L2/SLC39A4/NDUFS1/NDUFB5/SLC39A9/TUBA3D/NDUFS4/TRAP1/HTRA2/MAOA/ATF6/MT-ND4L/TUBA1A/BCL2L1/KLC4/MAPK10/NDUFB10/MAPK8/NDUFA5/MT-ND3/MFN2/SLC39A14/LRRK2/UBE2J2/DDIT3/EIF2AK3/MT-ND2/SLC39A2/PLCG1/PSMD6/APAF1/ATF4/CASP3	-1.42248897700737
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	5/2452	31/9376	0.616744724517182	H6PD/PFKM/FBP1/PGD/PRPS1	-1.27188157846585
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	5/2452	31/9376	0.616744724517182	ALDH9A1/GUSB/ALDH3A2/AKR1A1/UGDH	-1.27188157846585
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	16/2452	82/9376	0.746110691123224	NME4/NME3/GSTT1/GSTM3/IMPDH1/CES2/GUSB/TK2/UCK1/TYMP/NME7/GSTM2/MGST2/HPRT1/RRM2B/CDADC1	-1.37409685947222
NA	NA	hsa04519	Cadherin signaling	93/2452	404/9376	0.880235168704472	CDH11/GJA1/PCDH10/WNT2/PDGFRA/DES/PCDH18/YAP1/FZD2/VIM/PRICKLE1/WNT2B/RRAS/ENAH/WNT5B/RYK/CREBBP/PCDH7/AMOTL1/MAPK14/PDGFRB/FGFR1/FZD1/FZD7/MPDZ/DCHS1/IGF1R/DAAM1/ARHGAP35/ADAM10/ROCK2/ROCK1/MYO1D/APC/LRP5/ABI2/MYO1C/TJP1/KRAS/PKP1/LRP6/LATS2/TAOK1/TAOK2/RERE/ATN1/FZD4/FAT4/LHFPL2/NCKAP1/APH1A/DVL3/TCF7L1/DVL2/MAPK1/WTIP/AJUBA/VANGL1/PCDHGC3/FZD6/SHOC2/CDH18/NFKB1/PCDHAC2/MRAS/NF2/RAF1/PRICKLE2/WNT11/PSEN1/YWHAH/CDH7/LATS1/AMOTL2/WNT3/MAPK10/PSEN2/MAPK8/NCSTN/PCDHGA3/CDH15/MAP2K2/CDH8/DAAM2/GSK3B/SAV1/IKBKG/FAT1/EVL/IKBKB/RELA/TEAD2/PCDHGA10	-1.46434260614936
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	20/2452	100/9376	0.764763458401305	IL6ST/TNFRSF1A/CSF1/CXCL14/IL6R/IL34/LTBR/IL18/IL10RB/TNFRSF14/XCL1/IL18R1/CCL18/CCL28/CXCL9/PF4/CCL26/TNFRSF10D/PPBP/CCR10	-1.40731642821229
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/2452	16/9376	0.477977161500816	ALDH3B1/MAOA	-1.24359484260062
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	66/2452	298/9376	0.846885708967888	PRLR/IL6ST/TNFRSF1A/TGFBR2/TGFBR1/LIFR/BMP5/CSF1/CXCL14/GDF6/EPOR/ACVR2A/CNTFR/IL11RA/IL1R1/IL6R/OSMR/IFNGR2/IL34/BMPR2/LTBR/IL4R/TNFRSF12A/BMPR1A/CTF1/TNFSF13B/TGFB3/FAS/IL17RC/BMP4/IFNAR1/ACVRL1/TNFRSF11B/TNFSF15/ACVR1B/TGFB2/IL18/TNFSF12/BMP6/IL10RB/IL11/EDA/CLCF1/TNFRSF21/ACVR1/CSH2/TNFRSF14/XCL1/IL18R1/GHR/IL1RL1/CSH1/IFNGR1/CCL18/CCL28/CXCL9/CXCL16/PF4/CCL26/TSLP/IL17RE/CD4/TNFRSF10D/IL16/PPBP/CCR10	-1.59843916509367
Human Diseases	Substance dependence	hsa05034	Alcoholism	40/2452	191/9376	0.800799432880948	CREB3L1/CALM2/GNAI1/GNG11/ADORA2B/SHC2/KRAS/PKIA/GNAI2/CREB1/PRKACA/BDNF/ATF2/SOS1/HDAC7/GNB4/SLC29A3/MAPK1/PRKACB/ATF6B/SHC1/GRIN2D/CREB3/HDAC9/ARAF/HDAC3/FOSB/RAF1/CAMKK2/MAOA/HDAC4/GNB3/SOS2/CAMKK1/GNB2/GNGT1/HDAC11/NTRK2/GNG12/ATF4	-1.65514107046079
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	3/2452	23/9376	0.498758777218242	PCYOX1/ZMPSTE24/GGPS1	-1.43219638481868
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	5/2452	36/9376	0.531085735000906	ENPP1/GCK/G6PC3/GYG2/GYG1	-1.67740756972296
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	5/2452	37/9376	0.516732066487368	ALDH3B1/COMT/FAHD1/FAH/MAOA	-1.75269357655005
NA	NA	hsa04082	Neuroactive ligand signaling	39/2452	199/9376	0.749391328584193	SLC18A3/ADCY3/GNAI1/PRKCA/GNG11/ADCY9/P2RY1/ADORA2B/SLC1A3/PLCB1/GNAI2/OGFR/PRKACA/ADRA2A/SLC6A2/GABBR1/CHAT/GNB4/CHRM2/P2RX6/ADCY7/PRKACB/HRH2/GRIN2D/TAC3/ADCY6/GNA11/SLC17A9/P2RX4/GNB3/ADORA1/GLRB/POMC/P2RX1/DRD4/GNB2/GNGT1/OPRL1/GNG12	-2.12637377797807
Organismal Systems	Digestive system	hsa04976	Bile secretion	15/2452	90/9376	0.637302882001088	ATP1B1/ADCY3/ATP1A1/SLC4A2/ADCY9/ATP1A2/EPHX1/PRKACA/ADCY7/PRKACB/ABCC4/ADCY6/AQP1/SLC9A1/ABCC3	-2.05739822707955
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/2452	15/9376	0.254921152800435	AK1	-1.71851798818574
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	6/2452	46/9376	0.498758777218242	FTL/GUSB/UROD/EARS2/HMOX2/BLVRA	-2.02792652733654
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	4/2452	35/9376	0.437007690515031	PFKM/FBP1/GMPPA/PMM2	-1.98567030006034
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	4/2452	36/9376	0.424868588000725	POLD4/RFC1/POLD2/RNASEH2B	-2.05736923800964
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	16/2452	99/9376	0.6179906734556	CFD/C1R/HLA-DRA/C1S/HLA-DPA1/CFH/HLA-DPB1/HLA-DQA2/HLA-DMA/FCGR3A/C2/HLA-DMB/HLA-DRB1/HLA-DQA1/FPR3/ITGB2	-2.27381499733208
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	9/2452	66/9376	0.521429630728163	HSD17B2/HSD3B2/HSD17B11/HSD17B6/COMT/HSD11B2/HSD11B1/AKR1C1/HSD11B1L	-2.32172230939668
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/2452	26/9376	0.29413979169281	FADS2/PLA2G4A	-2.14470176913111
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	2/2452	26/9376	0.29413979169281	GCK/HES1	-2.14470176913111
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	3/2452	33/9376	0.347619753818775	PDHB/DLD/DLST	-2.2339936757855
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	5/2452	46/9376	0.415632314348535	PSMB8/PSMB9/PSMC2/PSMF1/PSMD6	-2.36424036489681
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	8/2452	63/9376	0.485564100572257	PTGIS/EPHX2/PTGES/GGT5/CYP2U1/PLA2G4A/PTGDS/PTGS1	-2.4379460040555
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/2452	28/9376	0.273129806571895	MOCS2/GPHN	-2.29215438474176
Genetic Information Processing	Transcription	hsa03040	Spliceosome	45/2452	243/9376	0.708114313334542	FUS/HSPA1A/THOC2/DDX42/SLU7/SF1/PRPF38B/WBP11/SF3B3/PRPF8/SF3B1/PRPF6/DHX38/CCDC12/PQBP1/U2SURP/HSPA1B/CDC40/SF3B5/SNRNP200/XAB2/CDC5L/PLRG1/SYF2/U2AF1L4/PPIE/SF3B4/HSPA6/SRSF4/SRSF5/THOC6/PRPF18/DHX15/DDX39B/SF3B2/CHERP/SF3A1/GPKOW/CWC15/USP39/SRSF10/DHX8/SNW1/AQR/SRSF1	-2.74332049652962
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/2452	36/9376	0.318651441000544	GUSB/AKR1A1/UGDH	-2.43733090629632
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	4/2452	43/9376	0.355703934140142	CD36/ABCA1/AGPAT2/AGPAT1	-2.51986001893348
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	22/2452	138/9376	0.609594061044518	SDHD/ATP6V0D1/ATP6V1G1/UQCRC2/COX7A1/UQCRB/ATP6V1C1/NDUFS1/NDUFB5/NDUFS4/ATP6AP1/TCIRG1/ATP6V0A1/ATP6V1D/MT-ND4L/NDUFB10/NDUFA5/MT-ND3/LHPP/MT-ND2/ATP6V0B/ATP6V0A2	-2.74937716565963
Organismal Systems	Sensory system	hsa04742	Taste transduction	11/2452	86/9376	0.489092909442695	P2RY1/PLCB1/PRKACA/GABBR1/PRKACB/ENTPD2/ADCY6/TAS1R3/GNB3/CACNA1C/TAS2R14	-2.83237426789574
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	8/2452	70/9376	0.437007690515031	GSTT1/SULT1A1/GSTM3/EPHX1/HSD11B1/HSD11B1L/GSTM2/MGST2	-2.81343768141238
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	8/2452	73/9376	0.419048470356879	GSTT1/FMO1/ALDH3B1/GSTM3/FMO4/MAOA/GSTM2/MGST2	-2.96522163813702
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	9/2452	79/9376	0.435624754785554	GSTT1/ALDH3B1/GSTM3/EPHX1/HSD11B1/AKR1C1/HSD11B1L/GSTM2/MGST2	-2.99762586935486
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/2452	30/9376	0.127460576400217	PLA2G4A	-2.84839450427272
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	28/2452	195/9376	0.549060944493245	PRKCA/PIK3R1/CASP1/MAPK14/PLCB1/AKT2/PIK3CA/HDAC7/MAPK1/FCGR3A/HDAC9/CLCN3/HDAC3/NFKB1/RAF1/CLCN5/MAP3K7/CLCN4/HDAC4/MAP2K2/AKT3/HDAC11/PLCG1/PIK3R2/RELA/SRC/FPR3/ITGB2	-3.78667039600416
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	5/2452	68/9376	0.28116303617695	CYP2W1/HSD17B6/DHRS4L2/DHRS4/RDH11	-3.54016913811109
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	35/2452	238/9376	0.562326072353901	RPS4Y1/IL6ST/TNFRSF1A/CFD/C7/C1R/IL6R/PRKCA/PIK3R1/CASP1/MAPK14/C1S/NRP1/STAT3/JUN/IFNAR1/PIK3CA/FOS/MAPK1/TAB2/TLR3/C2/NFKB1/ADAR/IFIH1/MAP3K7/MAPK10/MAPK8/IRAK4/IKBKG/PLCG1/TRAF6/PIK3R2/IKBKB/RELA	-4.06987358303483
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/2452	41/9376	0.0932638363904031	GRIN2D	-3.46244629493749
NA	NA	hsa04382	Cornified envelope formation	30/2452	217/9376	0.528638335300441	S100A4/S100A10/DST/PPL/CLDN11/S100A16/PPP2CB/EPHX2/TJP1/COL4A5/PKP1/UGCG/KAZN/PLEC/PPP2R5E/CLDN23/SPTLC2/S100A6/PPP2R2D/BLMH/CLDN12/PPP2R3C/PPP2R5B/PPP2R1A/PPP2R5A/SPTLC1/KDSR/CLDN15/TMEM79/S100A13	-4.180492396683
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	20/2452	183/9376	0.417903529181041	RPP25/XRN1/UTP14C/SBDS/CSNK2A1/RIOK2/MPHOSPH10/TBL3/CSNK2B/RPP25L/NXT1/REXO2/CSNK2A2/WDR75/IMP3/HEATR1/NMD3/SNORD3B-1/DROSHA/WDR36	-4.73215784609194
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	56/2452	370/9376	0.578739914465852	PRLR/NR3C1/NPW/ADRB3/THRA/LPAR1/GLP2R/CYSLTR2/PTH1R/LYPD6/PTGER2/P2RY1/ADORA2B/PTGFR/EDNRB/PTGER1/PTGIR/NPY1R/SSTR1/TBXA2R/PGRMC1/OGFR/BDKRB1/ADRA2A/GABBR1/CHRM2/P2RX6/CSH2/HRH2/GRIN2D/KNG1/TAC3/PGRMC2/GHR/CSH1/S1PR5/S1PR3/GIP/PTH2R/NMUR1/VIPR2/P2RX4/ADORA1/GLRB/POMC/P2RX1/DRD4/UCN/TSPO/OPRL1/MC1R/NPFFR2/LPAR6/FPR3/PTGER4/CHRNA9	-4.9198577255076
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	13/2452	143/9376	0.347619753818775	C7/C1R/HLA-DRA/C1S/HLA-DPA1/HLA-DPB1/HLA-DQA2/HLA-DMA/FCGR3A/C2/HLA-DMB/HLA-DRB1/HLA-DQA1	-4.67804876604224
Genetic Information Processing	Translation	hsa03010	Ribosome	6/2452	222/9376	0.103346413297474	RPS4Y1/MRPS6/MRPL10/MRPL43/MRPL28/MRPL32	-8.04568573034078
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	10/2452	449/9376	0.0851629686415707	CALM2/ADCY3/PRKG1/CAMK2D/CAMK2A/PRKACA/PRKACB/SLC8A1/NCALD/ARRB1	-11.8217420976537