category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	152/2910	250/9376	1.95897182130584	CTSK/CD68/CTSB/CTSS/CTSC/DEPTOR/CD63/ARSG/BLOC1S6/NPC2/MCOLN1/PSAP/IDS/HEXA/TPP1/RRAGA/CTSO/M6PR/ARL8A/NCOA7/CTSH/AP1S2/CTSD/MITF/GNPTG/ATP6V1D/CLTB/CTSA/LIPA/OSBPL5/FUCA2/SCARB2/ACP2/NAGLU/LAMP1/ARSA/GNS/OSTM1/LAPTM4A/OSBPL1A/SUMF1/SGSH/ATP6V0D1/LAMP2/LITAF/SNAPIN/AP2M1/IGF2R/HYAL2/ATP6V0A1/SMPD1/GLB1/VPS13C/GUSB/GALNS/DNASE2/AP3S1/KXD1/CTBS/BLOC1S1/VPS13A/AP1M1/HGSNAT/VPS26B/ASAH1/VPS41/VPS16/RAB7A/TFE3/DMXL2/PPT1/LAMTOR1/CLTC/AP4M1/ATP6V0E1/AGA/ARL8B/OSBP/ATP6V1H/AP2B1/TMEM175/PLA2G15/ENTPD4/VPS26A/CLCN7/ATP6AP1/SLC15A4/DTNBP1/CTSF/ATP6V1C1/RRAGC/NAGPA/BLOC1S5/BLOC1S2/LAPTM5/RRAGB/SLC17A5/CTSZ/ATP6V1G1/SLC36A4/TCIRG1/AKT1S1/RRAGD/GNPTAB/AP5Z1/SPG11/BLOC1S3/GGA1/ACP5/FIG4/AP2A2/AP5S1/AP5M1/VPS18/TPCN1/SLC15A3/AP4S1/GALC/ATP6V0B/GPR155/PLEKHM1/DMXL1/CLN8/SLC11A1/LAMTOR2/CTNS/IDUA/WDR7/TLR7/VPS39/ARSB/MANBA/SLC2A6/VPS11/LAMTOR4/PIKFYVE/MFSD8/LGMN/TPCN2/OSBPL2/MTOR/AP3S2/CLTCL1/AP2S1/AP4B1/ZFYVE26/ATP6V1E2/AP3M2/ATP6V1G2/MCOLN3/MAN2B1/OSBPL7	10.3097919315916
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	146/2910	248/9376	1.89681853453054	TUBA1A/SNX9/RRAS/DYNLT3/MYL9/AHNAK2/ACTG1/ROCK2/PKN1/TNFRSF1A/AKT3/MAPK14/STX10/M6PR/ARL8A/FLNA/TXN/DYNC2LI1/DCTN2/KPNA3/JUN/PAK3/TRADD/CYTH2/KIF5B/MYD88/RHOB/FADD/DYNC1H1/PLEKHM2/RAB9A/DYNC1LI1/KLC1/FYCO1/ACTR1A/TUBA3E/PODXL/BCL2/DCTN6/ACTR10/EXOC5/BIRC2/WASL/RELA/TUBB2A/RHOG/PFN2/EXOC7/DYNC2H1/MYO6/VPS41/BRK1/TCF7L2/ARF1/VPS16/PIK3CA/RAB7A/MAPK1/DYNC1I2/IKBKG/CASP1/RAB5C/ACTR1B/DYNC1LI2/ABI1/ARL8B/RALA/RAB5A/NFKB1/MAPK10/AKT2/RAF1/RILP/MAP2K1/DCTN1/IKBKB/MAP2K2/MAPK8/MYL5/MAP3K7/ACBD3/LY96/IRAK1/SNX18/GCC2/IL18/KPNA1/RAB5B/DYNLRB1/HSP90B1/NCKAP1L/DCTN3/EXOC4/PYCARD/TLR4/RIPK2/MAP2K7/NAIP/KIF5A/IRAK4/TAB2/SNX33/VPS18/MLKL/MYC/PTPRC/AHNAK/RIPK1/PIK3C3/BIRC3/PLEKHM1/TRAF6/CHUK/RHOA/WASF3/MAP2K4/CYTH1/CYTH4/VPS39/DYNLT1/CD14/PIK3CD/TLR5/NOD1/ELMO2/TLR2/VPS11/KLC2/TUBB2B/EXOC2/ARHGEF26/TUBA3D/TAB3/MAPK12/MAPK11/MYL12B/KIF5C/FHOD1/TLR6/PIK3CG/DYNLRB2/TUBA4A/RHOH/PFN4/RAB9B/RHOJ	9.6018934522992
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	109/2910	169/9376	2.07809024176986	IRS2/RRAS/CTSB/DEPTOR/IRS1/MRAS/PIK3R1/MAP1LC3A/CFLAR/RHEB/WDR45/RRAGA/AKT3/CTSD/IGF1R/GABARAP/VMP1/WDR41/GABARAPL1/PRKACB/RB1CC1/OPTN/CALCOCO2/LAMP1/ERN1/LAMP2/DAPK3/EIF2AK4/BCL2/STX7/WIPI1/GABARAPL2/NBR1/BCL2L1/ULK1/TANK/BECN1/ATG7/HIF1A/VPS41/ULK2/UVRAG/VPS16/PIK3CA/RAB7A/GORASP2/MAPK1/RRAS2/PRKAA1/PDPK1/PPP2CB/PRKACA/CAMKK2/MAPK10/AKT2/SH3GLB1/PPP2CA/WDFY3/WIPI2/RAF1/ATG4A/MAP2K1/MAP2K2/MAPK8/RRAGC/ATG4B/NRBF2/MAP3K7/KRAS/STK11/RRAGB/BIRC6/ATG13/BAD/TAX1BP1/AKT1S1/SUPT20H/RRAGD/RPS6KB1/MTMR3/PTEN/DDIT4/ATG16L2/VPS18/TP53INP2/SQSTM1/MAP1LC3B/ATG14/ATG16L1/PIK3C3/EIF2AK3/PLEKHM1/ZFYVE1/ATG4D/TRAF6/RAB33B/VPS39/ATG2B/PIK3CD/VPS11/PIK3R4/MTOR/TSC2/EPG5/ATG2A/AMBRA1/PIK3R2/DAPK2/PRKAA2	9.48754127693218
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	125/2910	224/9376	1.79798723613157	IL15/HLA-B/CHEK2/HLA-A/HLA-C/B2M/HLA-E/PIK3R1/IL1R1/IL15RA/TNFRSF1A/ADCY1/HLA-F/HLA-DPB1/AKT3/TGFBR2/PRKACB/HLA-DQA2/RELB/JAK1/JUN/TGFBR1/HLA-DRA/CREB3/ADCY3/CREB3L2/HLA-DPA1/CREB3L1/CREBBP/TSPO/HLA-DMB/TLN2/ETS1/TLN1/BCL2L1/RELA/ANAPC13/CDK4/HLA-DMA/CDKN2B/PPP3CB/RB1/PPP3CC/ETS2/SMAD2/CDC27/NFATC4/PIK3CA/HLA-DQA1/LTBR/MAPK1/XIAP/IKBKG/CDC26/STAT5B/PRKACA/NFKB1/MAP3K3/MAPK10/ATF2/AKT2/ATF6B/ANAPC7/CREB1/SMAD4/ELK4/MAP2K1/IKBKB/MAP2K2/MAPK8/CREB5/CCND2/NFKB2/KRAS/MMP7/CRTC1/MAD1L1/CDC16/SMAD3/NRP1/ITGB2/ZFP36/SPI1/ATM/PTEN/ADCY7/CD4/HLA-DQB1/VAC14/CD40/IL1R2/HLA-DOA/TGFB2/HLA-DRB1/ANAPC16/KAT5/GPS2/CDKN2C/MYC/RANBP3/ELK1/ATR/IL2RA/CHUK/FOSL1/MAP2K4/CRTC2/ADCY9/CDKN1A/PIK3CD/STAT5A/SRF/IL2RG/ICAM1/ITGAL/KAT2B/TBP/TGFB3/JAK3/TRRAP/ANAPC2/ADCY6/NFATC2/PIK3R2/NFATC1	8.10916674733968
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	136/2910	250/9376	1.75276426116839	RAB31/PDGFRA/ARFGAP3/HLA-B/PIP5K1C/HLA-A/HLA-C/HLA-E/EHD2/PSD3/SMAP1/HLA-F/TGFBR2/IGF1R/GRK5/CLTB/RAB22A/EGFR/PLD1/TGFBR1/CYTH2/KIF5B/BIN1/CHMP3/PSD/AP2M1/IGF2R/SNX1/VPS37A/ASAP2/CAV2/ZFYVE16/RUFY2/AGAP3/STAM/WASL/SMAP2/RAB11FIP2/RABEP1/PDCD6IP/GIT2/EEA1/RAB11B/SH3KBP1/VPS26B/CAPZA2/STAM2/HGS/SMAD2/ARF5/RUFY1/SRC/ARF1/CHMP4A/RAB7A/PML/VPS28/CLTC/RAB5C/VPS4B/RAB5A/SNF8/IST1/EPN2/AP2B1/CHMP4B/USP8/RNF41/SH3GLB1/ACAP2/CAPZB/ARF3/CHMP1B/VPS26A/VPS4A/ARAP1/ACAP1/RAB4A/STAMBP/GRK4/EHD1/ARFGEF1/CHMP1A/CHMP7/SPG21/PRKCI/SMAD3/RAB5B/ARFGAP2/GBF1/CHMP6/SNX12/SMURF2/ACAP3/AP2A2/ARF4/KIF5A/LDLR/RAB35/DNM1/AMPH/CHMP5/ZFYVE27/EHD4/WIPF3/CXCR4/WIPF2/VPS45/PARD6G/WWP1/HSPA1A/ZFYVE9/ARAP2/RAB11FIP3/TRAF6/GRK6/IL2RA/ARRB2/RHOA/CAV1/CYTH1/CYTH4/SNX6/IQSEC2/IL2RG/VPS37C/CLTCL1/AP2S1/FOLR2/PIP5K1B/ARAP3/KIF5C/HSPA1B/HSPA6/PARD6A/VPS37D	8.09287899160198
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	93/2910	155/9376	1.93319587628866	C3/ITGB5/TUBA1A/HLA-B/CTSS/HLA-A/HLA-C/ACTG1/HLA-E/THBS1/C1R/PLA2R1/HLA-F/HLA-DPB1/M6PR/ITGAV/ATP6V1D/HLA-DQA2/LAMP1/STX12/HLA-DRA/TAP1/HLA-DPA1/ATP6V0D1/LAMP2/DYNC1H1/HLA-DMB/THBS3/DYNC1LI1/TUBA3E/VAMP3/ATP6V0A1/COLEC11/STX7/FCGR3A/STX18/TUBB2A/HLA-DMA/MSR1/EEA1/DYNC2H1/HGS/HLA-DQA1/THBS2/RAB7A/SEC61A1/DYNC1I2/RAB5C/DYNC1LI2/ATP6V0E1/RAB5A/ATP6V1H/ITGB3/SEC61B/ATP6AP1/RILP/ATP6V1C1/MRC2/ATP6V1G1/TCIRG1/NCF2/RAB5B/ITGB2/SCARB1/HLA-DQB1/TLR4/CLEC4M/HLA-DOA/HLA-DRB1/FCGR2A/ITGB1/PIK3C3/FCGR1A/ATP6V0B/ITGA2/CD36/CD14/TLR2/PIKFYVE/ITGAM/TUBB2B/CYBB/TUBA3D/ATP6V1E2/CYBA/CORO1A/SEC61A2/MARCO/ATP6V1G2/TLR6/TUBA4A/SEC61G/COMP	7.85893924959388
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	163/2910	333/9376	1.5771317709462	FOXO1/ITGB5/PDGFRB/TNXB/WNT4/ITGB8/HLA-B/VEGFA/HLA-A/HLA-C/HLA-E/THBS1/WNT5A/LAMA4/PIK3R1/TNFRSF1A/RHEB/HLA-F/AKT3/TADA3/STAT1/IFNAR1/ITGAV/WNT5B/ATP6V1D/LAMB2/PRKACB/COL6A3/EGFR/RFNG/JAK1/TRADD/LAMC1/FAS/LFNG/VTN/HES4/COL4A4/MX2/FADD/CREB3/CREB3L2/CREB3L1/MAGI1/ATP6V0D1/CREBBP/THBS3/ATP6V0A1/PPP2R3C/RELA/CHD4/CDK4/RBPJ/RB1/MX1/PPP2R5E/TCF7L2/WNT9A/PIK3CA/THBS2/MAPK1/STAT2/PPP2CB/TNC/IKBKG/WNT2/ATP6V0E1/EIF2AK2/APC/UBE3A/MAML2/PRKACA/SPP1/ATP6V1H/NFKB1/AKT2/RBL2/PPP2CA/LAMB1/CREB1/ITGB3/PTK2/PPP2R5B/RAF1/ATP6AP1/FZD2/UBR4/MAP2K1/IKBKB/ITGA1/MAP2K2/ATP6V1C1/CREB5/CCND2/CDKN1B/KRAS/ATP6V1G1/PPP2R2D/PRKCI/TCIRG1/NOTCH2/BAD/WNT6/ITGA3/SOS2/RPS6KB1/LAMC3/TRAF3/ATM/PTEN/PSEN1/DVL2/HES6/LAMA3/PTGER4/CSNK1A1/MAML1/NFX1/NOTCH1/ITGB1/ATP6V0B/SOS1/COL4A6/PARD6G/NOTCH3/TUBG2/PPP2R3A/ITGA2/OASL/ATR/FZD3/CHUK/COL4A3/TICAM1/COL4A5/CDKN1A/PIK3CD/IRF9/WNT3/MTOR/MAML3/TSC2/ITGA4/FZD10/NOTCH4/FZD1/TBP/DLG3/FZD4/IKBKE/MFNG/ATP6V1E2/LAMB3/FZD8/HES1/HEYL/TYK2/ATP6V1G2/PARD6A/JAG1/PIK3R2/COL6A2/COMP	7.19374628419881
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	110/2910	203/9376	1.74590760584362	PDGFRA/ZYX/ITGB5/PDGFRB/EMP1/TNXB/RAP1B/FYN/ITGB8/VEGFA/MYL9/PIP5K1C/ACTG1/CAPN2/THBS1/LAMA4/PIK3R1/ROCK2/PDGFD/AKT3/ITGAV/IGF1R/PARVA/LAMB2/FLNA/COL6A3/EGFR/JUN/ILK/PAK3/LAMC1/VTN/VCL/COL4A4/THBS3/RAP1A/BCAR1/TLN2/CAV2/BCL2/VEGFB/MYLK/TLN1/BIRC2/ARHGAP5/PRKCA/SHC1/SRC/PIK3CA/THBS2/MAPK1/PARVB/XIAP/PDPK1/TNC/SHC2/CRK/SPP1/KDR/PDGFC/MAPK10/ARHGAP35/AKT2/LAMB1/VEGFC/ITGB3/PTK2/RAF1/IGF1/MAP2K1/ITGA1/MAPK8/CCND2/MYL5/PPP1R12A/ROCK1/BAD/ITGA3/SOS2/LAMC3/PTEN/LAMA3/PPP1R12C/ITGB1/PAK2/BIRC3/SOS1/COL4A6/DOCK1/ELK1/EMP2/PPP1R12B/PARVG/ITGA2/COL4A3/RHOA/CAV1/VAV1/COL4A5/PIK3CD/RAC2/PDGFA/ITGA4/PIP5K1B/LAMB3/MYL12B/SHC3/PIK3R2/COL6A2/COMP	7.2076159940398
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	70/2910	112/9376	2.01374570446735	IFNGR2/LAMA4/STAT3/TNFRSF1A/HLA-DPB1/AKT3/MAPK14/STAT1/LAMB2/HLA-DQA2/GNAI2/JAK1/LAMC1/IFNGR1/MYD88/HLA-DRA/HLA-DPA1/HLA-DMB/BCL2/BIRC2/BCL2L1/RELA/HLA-DMA/SOCS1/HLA-DQA1/MAPK1/XIAP/PDPK1/IKBKG/NFKB1/MAPK10/AKT2/LAMB1/GNAO1/IKBKB/MAPK8/MAP3K7/LY96/IRAK1/BAD/LAMC3/ALOX5/JAK2/HLA-DQB1/TLR4/LAMA3/CD40/HLA-DOA/TGFB2/IRAK4/LDLR/HLA-DRB1/TAB2/ITGB1/BIRC3/HSPA1A/TRAF6/CHUK/TLR2/CIITA/PIK3R5/IL10/TGFB3/LAMB3/MAPK12/MAPK11/TYK2/HSPA1B/HSPA6/PIK3CG	7.24024142089288
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	99/2910	181/9376	1.76230563308082	SPHK1/C3/IFNGR2/CTSS/PLA2R1/TNFRSF1A/HLA-DPB1/AKT3/MAPK14/STAT1/CTSD/HLA-DQA2/CALM2/JAK1/TRADD/LAMP1/IFNGR1/MYD88/HLA-DRA/LSP1/FADD/HLA-DPA1/ATP6V0D1/CREBBP/LAMP2/HLA-DMB/CARD9/ATP6V0A1/BCL2/FCGR3A/RELA/HLA-DMA/PPP3CB/EEA1/PPP3CC/PLK3/SRC/HLA-DQA1/RAB7A/ARHGEF12/MAPK1/RAB5C/RAB5A/ATP6V1H/NFKB1/MAPK10/AKT2/CD74/CREB1/MALT1/RAF1/ATP6AP1/MAPK8/IRAK1/BID/MRC2/CAMK2D/IL18/TCIRG1/BAD/RAB5B/ITGB2/JAK2/HLA-DQB1/TLR4/RIPK2/CLEC4M/HLA-DOA/TGFB2/IRAK4/CAMP/HLA-DRB1/SYK/FCGR2A/PIK3C3/FCGR1A/ATP6V0B/VDR/CR1/SPHK2/TRAF6/TLR1/RHOA/CD14/TLR2/CIITA/RFX5/ITGAM/CASP10/ITGAX/IL10/CEBPB/TGFB3/MAPK12/MAPK11/CORO1A/FCER1G/RFXAP/TLR6	6.94715249757969
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	107/2910	204/9376	1.68996698335692	SDC2/CD44/ITGB5/WNT4/RRAS/VEGFA/TIMP3/DCN/LUM/CD63/ACTG1/MRAS/THBS1/MSN/ESR1/WNT5A/PIK3R1/ROCK2/STAT3/PLAU/AKT3/MAPK14/ITGAV/WNT5B/IGF1R/TWIST1/FLNA/PRKACB/FGF2/EGFR/FAS/VTN/PLAUR/PTPN11/MMP2/TWIST2/CAV2/HSPB2/PRKCA/HIF1A/SMAD2/SRC/WNT9A/PIK3CA/ARHGEF12/MAPK1/RRAS2/PDPK1/WNT2/CTTN/PRKACA/KDR/ITPR2/AKT2/ITGB3/PTK2/RAF1/FZD2/IGF1/MAP2K1/MAP2K2/DDX5/KRAS/NUDT16L1/PPP1R12A/ARAF/FRS2/CAMK2D/HOXD10/ROCK1/WNT6/SOS2/RPS6KB1/PTCH1/TLR4/TGFB2/HPSE/MYC/PPP1R12C/ITGB1/SOS1/ELK1/MMP9/PPP1R12B/ITGA2/PLCE1/FZD3/RHOA/CAV1/VAV1/CDKN1A/PIK3CD/TLR2/PLCG1/SMO/WNT3/MTOR/FZD10/HBEGF/FZD1/FZD4/FZD8/MAPK12/MAPK11/PLCG2/ANK2/PIK3R2	6.68383395690721
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	76/2910	133/9376	1.84113892979872	FOXO1/IRS2/IRS1/HOMER3/GADD45G/PIK3R1/STAT3/AKT3/MAPK14/INSR/TGFBR2/IGF1R/GABARAP/GABARAPL1/SETD7/FBXO32/EGFR/TGFBR1/SOD2/CREBBP/CAT/CSNK1E/GABARAPL2/CDKN2B/PRKAG1/PLK3/PIK3CA/MAPK1/PRKAA1/PDPK1/PRKAG2/MAPK10/AKT2/RBL2/SMAD4/RAF1/IGF1/MAP2K1/IKBKB/MAP2K2/G6PC3/MAPK8/CCND2/CDKN1B/KRAS/STK11/ARAF/SOS2/SMAD3/STK4/ATM/PTEN/CCNG2/FBXO25/TGFB2/SGK1/SGK3/SOS1/CDKN2D/FOXO3/USP7/CHUK/BCL2L11/GADD45B/CDKN1A/PIK3CD/HOMER2/IL10/GADD45A/SIRT1/S1PR4/TGFB3/MAPK12/MAPK11/PIK3R2/PRKAA2	6.55392338329903
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	106/2910	205/9376	1.66600620233006	CD44/HLA-B/HLA-A/HLA-C/VIM/B2M/HLA-E/GADD45G/PIK3R1/STAT3/HLA-F/LYN/HLA-DPB1/AKT3/MAPK14/STAT1/IFNAR1/NCOR2/HLA-DQA2/RELB/JAK1/JUN/TRADD/FAS/MYD88/HLA-DRA/TAP1/FADD/HLA-DPA1/HLA-DMB/TAPBP/TAPBPL/BCL2/POLK/SAP30/RELA/CDK4/HLA-DMA/RBPJ/RB1/PSMC2/CD58/PSMD3/PIK3CA/SAP30L/HLA-DQA1/STAT2/OAS2/IKBKG/EIF2AK2/NFKB1/MAPK10/AKT2/OAS1/IKBKB/MAPK8/CCND2/NFKB2/CDKN1B/SNW1/MAP3K7/IRAK1/BID/ENTPD3/PSMC5/TRAF3/HLA-DQB1/MAP2K7/MAVS/CD40/HLA-DOA/IRAK4/HLA-DRB1/TAB2/SYK/MYC/RIPK1/CXCL10/TRAF5/USP7/TRAF6/DDB2/CHUK/BCL2L11/GADD45B/MAP2K4/NFKBIE/BTK/CDKN1A/PIK3CD/IRF9/TLR2/SIN3A/RUNX3/ICAM1/GADD45A/ITGAL/IKBKE/JAK3/HES1/MAPK12/MAPK11/TYK2/PLCG2/CD247/PIK3R2	6.46786788117598
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	79/2910	142/9376	1.7925173031315	CTSK/IFNGR2/FYN/PIK3R1/IL1R1/TNFRSF1A/AKT3/MAPK14/STAT1/IFNAR1/TGFBR2/MITF/FOSL2/RELB/JAK1/JUN/TGFBR1/IFNGR1/ATP2A2/FCGR3A/RELA/TREM2/PPP3CB/PPP3CC/SOCS1/CYLD/PIK3CA/MAPK1/STAT2/IKBKG/NFKB1/MAPK10/ITPR2/AKT2/CREB1/ITGB3/CSF1/LILRB4/JUND/MAP2K1/IKBKB/MAPK8/NFKB2/MAP3K7/NCF2/SIRPA/TNFRSF11B/SPI1/GAB2/OSCAR/ACP5/MAP2K7/LCP2/TGFB2/TAB2/SYK/SQSTM1/FCGR2A/SOCS3/FCGR1A/TRAF6/CHUK/FOSL1/LILRB2/BTK/PIK3CD/IRF9/LILRB1/TYROBP/LILRB3/JUNB/MAPK12/CYBA/MAPK11/TYK2/PLCG2/NFATC2/PIK3R2/NFATC1	6.38369710945999
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	96/2910	184/9376	1.68103989242492	DPYSL2/CFL2/WNT4/FYN/RRAS/ABLIM1/MYL9/TRPC4/WNT5A/PIK3R1/CXCL12/SEMA3C/ROCK2/WNT5B/ABL1/GNAI2/PLXNA4/ILK/PAK3/UNC5B/PTPN11/RHOD/BMPR2/NCK1/TRPC6/ABLIM3/PPP3CB/PRKCA/PPP3CC/BOC/SRC/NFATC4/PIK3CA/PLXNB2/ARHGEF12/MAPK1/PDPK1/PLXNC1/SSH1/LIMK1/CDK5/SEMA5A/SRGAP1/EFNA5/RGMA/PTK2/RAF1/MYL5/KRAS/NEO1/RYK/CAMK2D/SEMA6C/ROCK1/NRP1/SLIT3/PTCH1/EFNB1/GDF7/CXCR4/NTN4/NCK2/ITGB1/PAK2/CFL1/LRIG2/PARD6G/PLXNB1/EFNB2/FZD3/TRPC1/RHOA/ABLIM2/ENAH/PIK3CD/SEMA4D/PLCG1/PLXNA1/RAC2/SMO/EPHB6/RGS3/SEMA4A/EPHA2/ROBO2/MYL12B/PLCG2/EPHB2/SRGAP3/PARD6A/NTNG2/NFATC2/PIK3R2/EPHA6/UNC5C/EFNB3	6.25879515938591
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	57/2910	93/9376	1.97476998115508	IFNGR2/MAF/HLA-DPB1/MAPK14/STAT1/HLA-DQA2/JAK1/JUN/IFNGR1/HLA-DRA/HLA-DPA1/HLA-DMB/IL4R/RELA/HLA-DMA/PPP3CB/RBPJ/PPP3CC/HLA-DQA1/DLL1/MAPK1/IKBKG/STAT5B/MAML2/NFKB1/MAPK10/STAT6/IKBKB/MAPK8/NOTCH2/JAK2/CD4/HLA-DQB1/HLA-DOA/MAML1/HLA-DRB1/NOTCH1/NOTCH3/IL2RA/CHUK/NFKBIE/STAT5A/PLCG1/IL2RG/RUNX3/MAML3/IL12RB1/JAK3/MAPK12/MAPK11/LAT/TYK2/JAG1/CD247/NFATC2/STAT4/NFATC1	6.33743806225285
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	73/2910	130/9376	1.80927306370605	GNG4/VEGFA/PIK3R1/ADCY1/AKT3/MAPK14/TGFBR2/PRKACB/GNG11/GNAI2/EGFR/JUN/TGFBR1/EDNRB/COL4A4/CREB3/ADCY3/CREB3L2/CREB3L1/MMP2/GNB5/VEGFB/GNB2/RELA/RXFP1/PRKCA/SHC1/SMAD2/SRC/PIK3CA/MAPK1/SHC2/PRKACA/NFKB1/GNB1/MAPK10/ATF2/AKT2/ATF6B/CREB1/VEGFC/RAF1/GNAO1/MAP2K1/MAP2K2/MAPK8/CREB5/KRAS/SOS2/GNG2/GNB4/ADCY7/MAP2K7/ACTA2/MMP1/SOS1/COL4A6/MMP9/ARRB2/COL4A3/GNA15/MAP2K4/COL4A5/ADCY9/PIK3CD/PLCB2/MAPK12/MAPK11/GNGT2/ADCY6/GNB3/SHC3/PIK3R2	6.2331000716472
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	85/2910	163/9376	1.68018046507706	PIK3R1/STAT3/AKT3/MAPK14/STAT1/IFNAR1/TGFBR2/JAK1/JUN/TGFBR1/FAS/MYD88/FADD/CREB3/CREB3L2/CREB3L1/CREBBP/BCL2/RELA/RB1/PRKCA/SRC/NFATC4/PIK3CA/MAPK1/STAT2/IKBKG/STAT5B/NFKB1/MAPK10/ATF2/AKT2/ATF6B/YWHAQ/CREB1/SMAD4/STAT6/RAF1/ATP6AP1/MAP2K1/IKBKB/MAP2K2/MAPK8/CREB5/MAP3K7/KRAS/IRAK1/BID/ARAF/BAD/SOS2/SMAD3/TRAF3/JAK2/TLR4/MAP2K7/MAVS/TGFB2/IRAK4/TAB2/MYC/SOS1/ELK1/MMP9/TRAF6/DDB2/CHUK/TICAM1/MAP2K4/CDKN1A/PIK3CD/IFIH1/TLR2/STAT5A/CASP10/IKBKE/TGFB3/JAK3/MAPK12/MAPK11/TYK2/NFATC2/PIK3R2/STAT4/NFATC1	5.87667541270578
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	48/2910	77/9376	2.00851519614406	GADD45G/PIK3R1/AKT3/TGFBR2/ABL1/TGFBR1/PTPN11/POLK/CTBP2/BCL2L1/RELA/CDK4/RB1/SHC1/PIK3CA/MAPK1/SHC2/CRK/IKBKG/STAT5B/NFKB1/AKT2/SMAD4/RAF1/MAP2K1/IKBKB/MAP2K2/CDKN1B/KRAS/ARAF/BAD/SOS2/SMAD3/GAB2/TGFB2/MYC/SOS1/RUNX1/DDB2/CHUK/GADD45B/CDKN1A/PIK3CD/STAT5A/GADD45A/TGFB3/SHC3/PIK3R2	5.96106651424304
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	69/2910	125/9376	1.77854020618557	SPHK1/MAP3K5/FYN/SPTLC2/CERS6/S1PR3/PIK3R1/SPTSSA/ROCK2/TNFRSF1A/AKT3/MAPK14/CTSD/BDKRB2/GNAI2/TRADD/PLD1/DEGS1/CERS4/CERS2/ORMDL1/SMPD1/BCL2/PPP2R3C/RELA/PRKCA/PPP2R5E/ASAH1/SGPL1/PIK3CA/MAPK1/PDPK1/PPP2CB/GNA13/SPTLC1/ORMDL2/NFKB1/MAPK10/AKT2/PPP2CA/PPP2R5B/RAF1/MAP2K1/MAP2K2/MAPK8/ADORA1/KRAS/BID/PPP2R2D/ROCK1/SGMS1/GAB2/GNAQ/PTEN/NSMAF/SGMS2/ABCC1/PPP2R3A/SPHK2/ORMDL3/RHOA/PIK3CD/RAC2/PLCB2/S1PR4/MAPK12/MAPK11/FCER1G/PIK3R2	5.87835749494201
NA	NA	hsa04518	Integrin signaling	81/2910	154/9376	1.69468469674655	C3/FBN1/PDGFRA/ITGB5/PDGFRB/TNXB/ITGB8/VEGFA/ACTG1/THBS1/VCAM1/LAMA4/PIK3R1/FERMT2/PDGFD/AKT3/ITGAV/IGF1R/PARVA/LAMB2/FLNA/COL6A3/EGFR/LIMS2/ILK/LAMC1/VTN/VCL/COL4A4/FERMT3/THBS3/ITGAE/TLN2/LIMS1/VEGFB/TLN1/SRC/PIK3CA/THBS2/PARVB/TNC/SPP1/KDR/PDGFC/AKT2/LAMB1/ICAM2/VEGFC/ITGB3/PTK2/IGF1/ITGA1/CCND2/ITGA3/ITGB2/LAMC3/LAMA3/NCK2/ITGB1/COL4A6/PARVG/ARHGEF6/ITGA2/COL4A3/COL4A5/PIK3CD/FREM1/RAC2/ITGAM/ITGAX/PDGFA/MTOR/FGG/ITGA4/ICAM1/ITGAL/LAMB3/ITGAD/PIK3R2/COL6A2/COMP	5.83109095753655
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	98/2910	196/9376	1.61099656357388	CLEC2B/C3/GNG4/HLA-B/VEGFA/HLA-A/HLA-C/HLA-E/PIK3R1/MAP1LC3A/STAT3/TNFRSF1A/HLA-F/LYN/AKT3/MAPK14/STAT1/IFNAR1/MAPKAPK2/CALM2/FGF2/GNG11/IL6ST/JAK1/JUN/TRADD/FAS/IFNGR1/FADD/CREBBP/GNB5/MICA/GNB2/RELA/CDK4/PPP3CB/BECN1/RB1/PPP3CC/HIF1A/SRC/TCF7L2/NFATC4/PIK3CA/MAPK1/STAT2/IKBKG/EIF2AK2/NFKB1/GNB1/MAPK10/ITPR2/AKT2/CREB1/RAF1/MAP2K1/IKBKB/MAP2K2/MAPK8/KRAS/CD86/BID/ZFP36/GNG2/TRAF3/GNB4/JAK2/MAP2K7/RCAN1/SYK/MYC/MAP1LC3B/ATG14/PIK3C3/CHUK/TICAM1/MAP2K4/CDKN1A/PIK3CD/IRF9/PLCG1/HCK/MTOR/PIK3R5/ICAM1/MICB/IKBKE/MAPK12/MAPK11/TYK2/PLCG2/GNGT2/ANGPT2/PIK3CG/GNB3/NFATC2/PIK3R2/NFATC1	5.79908861624793
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	62/2910	109/9376	1.83269333837763	IFNGR2/IL1R1/STAT3/HLA-DPB1/MAPK14/STAT1/TGFBR2/HLA-DQA2/IL6ST/JAK1/JUN/TGFBR1/IFNGR1/HLA-DRA/HLA-DPA1/HLA-DMB/IL4R/RELA/HLA-DMA/PPP3CB/PPP3CC/HIF1A/SMAD2/RORA/HLA-DQA1/MAPK1/IKBKG/RARA/STAT5B/IL6R/NFKB1/MAPK10/SMAD4/STAT6/IKBKB/MAPK8/RXRB/SMAD3/JAK2/CD4/HLA-DQB1/HLA-DOA/HLA-DRB1/RUNX1/IL2RA/CHUK/NFKBIE/AHR/STAT5A/PLCG1/IL2RG/MTOR/IL12RB1/IL27RA/JAK3/MAPK12/MAPK11/LAT/TYK2/CD247/NFATC2/NFATC1	5.86601325908802
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	82/2910	157/9376	1.68282443583514	AXL/SPHK1/ITGB5/MFGE8/THBS1/PROS1/MAPK14/ITGAV/MAPKAPK2/LIPA/ATP8A2/ABCA1/TMEM30A/PTPN11/NR1H2/BCAR1/ATP2A2/C1QB/GAS6/LRP1/ADAM10/RAB14/C1QA/HIF1A/PBX1/VPS41/NFATC4/VPS16/RAB7A/MAPK1/CRK/CASP1/RAB5C/ADAM9/RAB5A/PLA2G15/CREB1/ITGB3/PTK2/CPT1C/HAVCR2/MAP2K1/MAP2K2/ATP11B/NR1H3/C1QC/CAMK2D/SIRPA/RAB5B/ALOX5/JAK2/PTGER4/SGK1/VPS18/PANX1/DOCK1/ATP11C/DUSP7/EPOR/SPHK2/CD36/VPS39/VPS8/DUSP8/GULP1/VPS11/TGFBRAP1/IL10/SIRT1/CPT1A/SIGLEC10/CEBPB/MERTK/PTGER2/MAPK12/MAPK11/DUSP2/XKR6/CX3CR1/NFATC2/NFATC1/GPR132	5.78803642893804
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	48/2910	78/9376	1.9827650013217	C3/IFNGR2/MARCKSL1/HLA-DPB1/MAPK14/STAT1/HLA-DQA2/EEF1A1/JAK1/JUN/IFNGR1/MYD88/HLA-DRA/HLA-DPA1/HLA-DMB/FCGR3A/RELA/HLA-DMA/HLA-DQA1/MAPK1/NFKB1/MAP3K7/IRAK1/NCF2/ITGB2/JAK2/HLA-DQB1/TLR4/HLA-DOA/TGFB2/IRAK4/HLA-DRB1/TAB2/FCGR2A/ITGB1/FCGR1A/ELK1/CR1/TRAF6/TLR2/ITGAM/ITGA4/IL10/CYBB/TGFB3/MAPK12/CYBA/MAPK11	5.84677652740158
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	59/2910	103/9376	1.84560771360891	C3/IFNGR2/SERPINE1/PIK3R1/CFLAR/ACE/TNFRSF1A/ADCY1/AKT3/MAPK14/TGFBR2/BDKRB2/GNAI2/JUN/TGFBR1/FAS/IFNGR1/MYD88/FADD/C1QB/RELA/C1QA/SMAD2/PIK3CA/MAPK1/PPP2CB/IKBKG/NFKB1/MAPK10/AKT2/PPP2CA/GNAO1/IKBKB/GNA11/MAPK8/C1QC/IRAK1/PPP2R2D/GNAQ/TLR4/TGFB2/IRAK4/TRAF6/CHUK/GNA15/TICAM1/MAP2K4/PIK3CD/TLR2/IL10/PLCB2/TGFB3/MAPK12/MAPK11/GNA14/TLR6/CD247/PIK3R2/GNAL	5.78884206412995
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	57/2910	99/9376	1.85508695199417	ESR1/NCOR1/PIK3R1/ADCY1/AKT3/MAPK14/IGF1R/PRKACB/EGFR/JUN/ADCY3/MMP2/BCL2/CDK4/RB1/SHC1/SRC/PIK3CA/DLL1/MAPK1/SHC2/PRKACA/MAPK10/AKT2/PTK2/RAF1/IGF1/MAP2K1/MAP2K2/MAPK8/CDKN1B/KRAS/ARAF/NOTCH2/BAD/SOS2/RPS6KB1/ADCY7/MED1/CDKN2C/NOTCH1/SOS1/NOTCH3/MMP9/SP1/ADCY9/CDKN1A/PIK3CD/MTOR/NOTCH4/HBEGF/MAPK12/MAPK11/ADCY6/JAG1/SHC3/PIK3R2	5.73770718621913
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	75/2910	142/9376	1.70175693335269	SDC2/PLAT/NFE2L2/MAP3K5/GSTT1/VEGFA/ACTG1/VCAM1/PIK3R1/IL1R1/TNFRSF1A/AKT3/MAPK14/ITGAV/GSTM3/MAPK7/MGST1/TXN/MEF2A/CALM2/DUSP1/ASS1/JUN/MMP2/BMPR2/CAV2/BCL2/RELA/ACVR1/ARHGEF2/SRC/PIK3CA/KEAP1/PRKAA1/IKBKG/NFKB1/KDR/MAPK10/AKT2/BMP4/ITGB3/PTK2/IKBKB/BMPR1A/MAPK8/MAP3K7/SUMO1/SUMO3/NCF2/HSP90B1/MAP2K7/NQO1/IL1R2/GSTM5/SQSTM1/SUMO2/GSTO1/MMP9/MAP2K5/CHUK/RHOA/CAV1/MAP2K4/PIK3CD/RAC2/MEF2C/ACVR2A/PDGFA/ICAM1/PIAS4/MAPK12/CYBA/MAPK11/PIK3R2/PRKAA2	5.65262573988716
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	137/2910	300/9376	1.47137686139748	PDGFRA/RASGRP2/PDGFRB/RAP1B/MAP3K5/RRAS/VEGFA/MRAS/DAXX/GADD45G/IL1R1/PDGFD/TNFRSF1A/AKT3/MAPK14/INSR/MAPK7/TGFBR2/IGF1R/MAPKAPK2/FLNA/PRKACB/FGF2/DUSP1/EGFR/MAP3K4/FGF7/MAP4K4/CACNB3/RELB/JUN/TRADD/RPS6KA3/TGFBR1/FAS/MYD88/NTRK1/RAP1A/MAP3K2/TAOK1/CDC25B/CACNA2D1/VEGFB/HSPB1/RELA/PPP3CB/PRKCA/PPP3CC/MAX/MAPK1/RRAS2/CACNB2/DUSP3/CRK/IKBKG/PRKACA/NFKB1/KDR/PDGFC/MAP3K3/MAPK10/ATF2/EFNA5/AKT2/VEGFC/CSF1/RAF1/JUND/MAPKAPK3/IGF1/ELK4/MAP2K1/IKBKB/MAP2K2/MAPK8/NFKB2/MAP3K7/KRAS/IRAK1/ARAF/MAP3K13/PPM1A/MAP4K3/SOS2/STK4/RASA2/FGF10/FLT3LG/MAP2K7/TGFB2/IRAK4/TAB2/MYC/PAK2/SOS1/HSPA1A/CACNA1G/ELK1/MAPK8IP1/TAOK2/MAP2K5/DUSP7/TRAF6/CHUK/ARRB2/GADD45B/MAP2K4/MAP3K10/DUSP8/CD14/CACNB1/NTRK2/RPS6KA2/RAC2/PTPN7/SRF/MAP3K12/MEF2C/CACNA2D4/PDGFA/DUSP10/PTPN5/GADD45A/CACNA1C/EPHA2/TGFB3/MAPK12/MAPK11/DUSP2/CACNA1H/HSPA1B/TEK/HSPA6/ANGPT2/CACNA1A/KITLG/NFATC1	5.56667577061921
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	47/2910	77/9376	1.96667112955773	VEGFA/GADD45G/PIK3R1/STAT3/AKT3/STAT1/TGFBR2/EGFR/JAK1/PLD1/TGFBR1/POLK/BCL2L1/RELA/CDK4/RB1/SMAD2/PIK3CA/MAPK1/IKBKG/RALA/NFKB1/MAPK10/AKT2/SMAD4/RAF1/MAP2K1/IKBKB/MAPK8/KRAS/ARAF/BAD/SMAD3/RPS6KB1/TGFB2/RALGDS/ARHGEF6/DDB2/CHUK/GADD45B/CDKN1A/PIK3CD/RAC2/MTOR/GADD45A/TGFB3/PIK3R2	5.71373730680894
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	73/2910	138/9376	1.7043876687086	PIP5K1C/ACTG1/PIK3R1/ROCK2/PKN1/AKT3/MAPK14/JUN/RPS6KA3/MYD88/BCAR1/WASF2/WASL/RELA/RHOG/GIT2/SRC/PIK3CA/ARHGEF12/MAPK1/CRK/IKBKG/CASP1/LIMK1/NFKB1/MAPK10/AKT2/PTK2/MAP2K1/IKBKB/MAP2K2/MAPK8/MAP3K7/IRAK1/IL18/ROCK1/PKN2/GNAQ/PYCARD/CD4/TLR4/MAP2K7/LCP2/IRAK4/TAB2/WIPF3/BAIAP2/FCGR2A/WIPF2/ITGB1/DOCK1/ARHGEF7/TRAF6/CHUK/RHOA/VAV1/TICAM1/MAP2K4/PIK3CD/ELMO2/PLCG1/RPS6KA2/RAC2/ITGA4/IL10/ARHGEF28/PIP5K1B/MAPK12/MAPK11/LAT/NFATC2/PIK3R2/NFATC1	5.59212140310998
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	65/2910	119/9376	1.7599122123076	IL15/MAP3K5/VCAM1/PIK3R1/CFLAR/TNFRSF1A/AKT3/MAPK14/TNFRSF1B/JUN/TRADD/MMP14/FAS/FADD/CREB3/CREB3L2/CREB3L1/BIRC2/RELA/RHBDF1/CYLD/PIK3CA/MAPK1/XIAP/IKBKG/NFKB1/MAPK10/ATF2/AKT2/ATF6B/CREB1/VEGFC/CSF1/MAP2K1/IKBKB/MAPK8/CREB5/BCL3/MAP3K7/TRAF3/MAP2K7/TAB2/MLKL/SOCS3/RIPK1/BIRC3/CXCL10/TRAF5/MMP9/CHUK/MAP2K4/PIK3CD/CASP10/ICAM1/IL18R1/MMP3/CEBPB/TAB3/JUNB/MAPK12/MAPK11/JAG1/PIK3R2/TRAF1/LIF	5.59649416587127
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	57/2910	101/9376	1.81835255690517	F3/FOXO1/SERPINE1/VEGFA/VCAM1/PIK3R1/PIM1/STAT3/AKT3/MAPK14/STAT1/TGFBR2/PLCD3/JUN/TGFBR1/COL4A4/MMP2/BCL2/VEGFB/RELA/PLCD1/CDK4/PRKCA/SMAD2/PIK3CA/MAPK1/STAT5B/NFKB1/MAPK10/AKT2/VEGFC/SMAD4/MAPK8/CDKN1B/KRAS/SMAD3/JAK2/TGFB2/AGTR1/COL4A6/PLCE1/COL4A3/COL4A5/NOX4/PIK3CD/STAT5A/PLCG1/AGT/ICAM1/PLCB2/CYBB/TGFB3/MAPK12/MAPK11/PLCG2/PIK3R2/NFATC1	5.5470036798702
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	108/2910	227/9376	1.53293065080158	GNG4/PDGFRA/AKAP13/HLA-B/VEGFA/HLA-A/HLA-C/B2M/HLA-E/PIK3R1/IL1R1/CXCL12/ROCK2/STAT3/TNFRSF1A/RHEB/ADCY1/HLA-F/AKT3/MAPK14/ITGAV/PRKACB/CALM2/GNG11/GNAI2/EGFR/JAK1/TRADD/FAS/TAP1/FADD/CREB3/ADCY3/CREB3L2/CREB3L1/TAPBP/TAPBPL/BCAR1/GNB5/GNB2/RELA/CDK4/PPP3CB/RB1/PRKCA/PPP3CC/SRC/NFATC4/PIK3CA/ARHGEF12/MAPK1/GNA13/CRK/IKBKG/PRKACA/IL6R/NFKB1/GNB1/ATF2/ITPR2/AKT2/ATF6B/CREB1/ITGB3/PTK2/RAF1/GNAO1/MAP2K1/IKBKB/GNA11/MAP2K2/CREB5/KRAS/BID/ROCK1/SOS2/RPS6KB1/GNG2/GNB4/GNAQ/ADCY7/PTGER4/MYC/CXCR4/RIPK1/SOS1/ARHGEF11/ELK1/TRAF5/SP1/CHUK/RHOA/ADCY9/CDKN1A/PIK3CD/RAC2/MTOR/TSC2/PLCB2/PTGER2/MAPK12/MAPK11/GNGT2/ADCY6/GNB3/NFATC2/PIK3R2/NFATC1	5.45269362345076
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	65/2910	120/9376	1.74524627720504	RAP1B/MAP3K5/IRS1/PIK3R1/KIDINS220/AKT3/MAPK14/MAPK7/ABL1/MAPKAPK2/CALM2/JUN/RPS6KA3/NTRK1/PTPN11/RAP1A/BCL2/RELA/ARHGDIA/SHC1/PIK3CA/MAPK1/PDPK1/SHC2/CRK/NFKB1/MAP3K3/MAPK10/AKT2/RAF1/MAP2K1/IKBKB/MAP2K2/MAPK8/KRAS/IRAK3/IRAK1/PRDM4/FRS2/CAMK2D/BAD/SOS2/RIPK2/PSEN1/MAP2K7/IRAK4/SH2B1/SOS1/PSEN2/SH2B3/FOXO3/MAP2K5/TRAF6/RHOA/NFKBIE/PIK3CD/PLCG1/NTRK2/RPS6KA2/MATK/MAPK12/MAPK11/PLCG2/SHC3/PIK3R2	5.51179489018063
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	52/2910	90/9376	1.86159602901871	FOXO1/IRS2/IRS1/PIK3R1/RHEB/ADCY1/AKT3/INSR/IGF1R/PRKACB/RB1CC1/SESN3/SOD2/CREB3/ADCY3/CREB3L2/CREB3L1/CAT/RELA/ULK1/PRKAG1/PIK3CA/PRKAA1/PRKAG2/PRKACA/CAMKK2/NFKB1/ATF2/AKT2/ATF6B/CREB1/APPL1/IGF1/CREB5/KRAS/STK11/ATG13/AKT1S1/RPS6KB1/SESN1/ADCY7/FOXO3/EHMT2/ADCY9/PIK3CD/MTOR/TSC2/SIRT1/KL/ADCY6/PIK3R2/PRKAA2	5.50966110174851
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	89/2910	180/9376	1.5930966017564	C3/IFNGR2/HLA-B/HLA-A/HLA-C/B2M/HLA-E/DAXX/PIK3R1/TNFRSF1A/RHEB/HLA-F/HLA-DPB1/AKT3/STAT1/PILRA/IFNAR1/HLA-DQA2/JAK1/TRADD/FAS/IFNGR1/MYD88/HLA-DRA/TAP1/FADD/HLA-DPA1/PTPN11/TNFRSF14/HLA-DMB/TAPBP/CARD9/TAPBPL/BCL2/SP100/HCFC2/BIRC2/BCL2L1/RELA/HLA-DMA/RNASEL/SRC/PIK3CA/HLA-DQA1/STAT2/PML/OAS2/IKBKG/EIF2AK2/NFKB1/AKT2/OAS1/CD74/EIF2B3/ITGB3/IKBKB/MAP3K7/IRAK1/BID/BAD/TRAF3/JAK2/HLA-DQB1/MAVS/EIF2B4/HLA-DOA/IRAK4/HLA-DRB1/TAB2/SYK/SOCS3/BIRC3/TRAF5/TRAF6/CHUK/TICAM1/PIK3CD/IRF9/IFIH1/TLR2/MTOR/POU2F2/TSC2/IKBKE/BST2/TNFSF14/TYK2/C5/PIK3R2	5.38984764926529
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	80/2910	158/9376	1.63138892513811	CAB39L/WNT4/MAPKAP1/DEPTOR/IRS1/WNT5A/PIK3R1/TNFRSF1A/RHEB/RRAGA/AKT3/INSR/WNT5B/IGF1R/ATP6V1D/RNF152/RPS6KA3/CAB39/ULK1/PRKCA/ULK2/LPIN1/WNT9A/PIK3CA/MAPK1/PRKAA1/PDPK1/LAMTOR1/WNT2/ATP6V1H/AKT2/RAF1/FZD2/IGF1/MAP2K1/IKBKB/MAP2K2/ATP6V1C1/RRAGC/SEC13/LPIN2/KRAS/SLC3A2/STK11/RRAGB/ATP6V1G1/WNT6/AKT1S1/SOS2/RRAGD/RPS6KB1/PTEN/DDIT4/DVL2/SGK1/SOS1/LAMTOR2/FZD3/CHUK/LRP6/RHOA/LPIN3/PIK3CD/LAMTOR4/RPS6KA2/WNT3/MTOR/FNIP2/TSC2/FZD10/WDR24/FZD1/WDR59/FZD4/ATP6V1E2/FZD8/PRR5L/ATP6V1G2/PIK3R2/PRKAA2	5.36934653509996
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	60/2910	110/9376	1.75745079662605	FBN1/NBL1/ID4/LEFTY2/EMP3/DCN/THBS1/NCOR1/TGFBR2/FMOD/TGFBR1/SMAD5/FST/INHBB/CHRD/CREBBP/BMPR2/ZFYVE16/ACVR1/CDKN2B/SMAD2/SMAD9/MAPK1/BAMBI/HAMP/PPP2CB/SKIL/THSD4/SKI/PPP2CA/BMP4/SMAD1/RGMA/SMAD4/BMPR1A/NEO1/LTBP1/ROCK1/SMAD3/TGIF1/RPS6KB1/SMURF2/TGFB2/GDF7/MYC/LEMD3/ACVR1B/ZFYVE9/SP1/RHOA/INHBA/SIN3A/GREM1/ACVR2A/BMP2/HFE/SMAD7/TGFB3/TGIF2/RGMB	5.36066791115667
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	65/2910	122/9376	1.71663568249676	IRS2/SOCS2/IRS1/IGFBP3/PIK3R1/STAT3/ADCY1/AKT3/MAPK14/STAT1/PRKACB/GNAI2/CREB3/ADCY3/CREB3L2/CREB3L1/CREBBP/BCAR1/PRKCA/SHC1/SOCS1/PIK3CA/MAPK1/SHC2/CRK/STAT5B/PRKACA/MAPK10/ATF2/ITPR2/AKT2/ATF6B/CREB1/PTK2/RAF1/IGF1/MAP2K1/GNA11/MAP2K2/MAPK8/CREB5/KRAS/SOS2/GNAQ/JAK2/ADCY7/SOCS3/SOS1/CSH1/MAP2K4/ADCY9/PIK3CD/STAT5A/PLCG1/MTOR/PLCB2/CACNA1C/JUNB/MAPK12/MAPK11/CSH2/PLCG2/ADCY6/SHC3/PIK3R2	5.34475594392954
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	76/2910	149/9376	1.64343273599483	SPHK1/PDGFRA/PDGFRB/FYN/RRAS/F2R/PIP5K1C/LPAR1/MRAS/PIK3R1/PDGFD/RHEB/ADCY1/AKT3/INSR/EGFR/PLD1/CYTH2/ADCY3/PTPN11/PRKCA/SHC1/AGPAT1/ARF1/PIK3CA/MAPK1/RRAS2/GNA13/SHC2/AGPAT3/RALA/PDGFC/AKT2/DGKH/RAF1/MAP2K1/MAP2K2/KRAS/AGPAT2/DGKE/LPAR6/SOS2/GAB2/ADCY7/DNM1/SYK/AGTR1/AGPAT4/SOS1/RALGDS/SPHK2/RHOA/CYTH1/CYTH4/ADCY9/DGKA/PIK3CD/PLCG1/AVPR1A/AGT/PDGFA/MTOR/PIK3R5/TSC2/PLCB2/PIP5K1B/LPAR5/DGKQ/PLCG2/FCER1G/ADCY6/DGKD/PIK3CG/SHC3/KITLG/PIK3R2	5.31104901185806
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	157/2910	362/9376	1.39738375956409	PRLR/GNG4/PDGFRA/ITGB5/PDGFRB/TNXB/ITGB8/F2R/VEGFA/LPAR1/IRS1/THBS1/LAMA4/PIK3R1/PKN1/PDGFD/PRL/OSMR/RHEB/AKT3/IFNAR1/ITGAV/INSR/IGF1R/LAMB2/FGF2/GNG11/COL6A3/EGFR/FGF7/JAK1/LAMC1/VTN/COL4A4/CREB3/CREB3L2/CREB3L1/MAGI1/NTRK1/THBS3/GNB5/BCL2/PPP2R3C/VEGFB/IL4R/GNB2/BCL2L1/RELA/CDK4/PRKCA/PPP2R5E/PIK3CA/THBS2/MAPK1/PRKAA1/PDPK1/PPP2CB/TNC/IKBKG/SPP1/IL6R/NFKB1/GNB1/KDR/PDGFC/ATF2/EFNA5/AKT2/ATF6B/RBL2/YWHAQ/PPP2CA/LAMB1/CREB1/VEGFC/ITGB3/PTK2/CSF1/PPP2R5B/RAF1/IGF1/MAP2K1/IKBKB/ITGA1/MAP2K2/G6PC3/CREB5/CCND2/CDKN1B/KRAS/STK11/PPP2R2D/PKN2/BAD/ITGA3/LPAR6/SOS2/RPS6KB1/LAMC3/HSP90B1/GNG2/GNB4/FGF10/PTEN/FLT3LG/JAK2/DDIT4/TLR4/LAMA3/SGK1/SYK/PHLPP2/MYC/ITGB1/SGK3/SOS1/COL4A6/PIK3AP1/PPP2R3A/FOXO3/ITGA2/EPOR/CSH1/IL2RA/CHUK/BCL2L11/COL4A3/CRTC2/COL4A5/CDKN1A/PIK3CD/TLR2/NTRK2/MAGI2/IL2RG/PDGFA/MTOR/PIK3R5/TSC2/ITGA4/EPHA2/LPAR5/LAMB3/JAK3/MCL1/CSH2/GNGT2/OSM/TEK/ANGPT2/PIK3CG/GNB3/KITLG/PIK3R2/COL6A2/COMP/PRKAA2	5.1727311310147
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	51/2910	90/9376	1.82579610538373	IFNGR2/PIK3R1/STAT3/AKT3/MAPK14/STAT1/EGFR/JAK1/JUN/IFNGR1/MYD88/PTPN11/RELA/PPP3CB/PPP3CC/HIF1A/PIK3CA/MAPK1/CSNK2A1/IKBKG/NFKB1/MAP3K3/AKT2/RAF1/MAP2K1/IKBKB/MAP2K2/KRAS/RPS6KB1/PTEN/JAK2/CD4/TLR4/TRAF6/CHUK/TICAM1/NFKBIE/PIK3CD/TLR2/PLCG1/MTOR/BATF3/MAPK12/MAPK11/LAT/BATF/BATF2/CD247/NFATC2/PIK3R2/NFATC1	5.28073079096025
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	59/2910	109/9376	1.74401462845613	FOXO1/IRS2/IRS1/PIK3R1/GFPT2/STAT3/TNFRSF1A/AKT3/INSR/RPS6KA3/CREB3/CREB3L2/CREB3L1/PTPN11/NR1H2/RELA/ACACB/PRKAG1/PIK3CA/PRKAA1/PDPK1/PTPN1/PRKAG2/MLXIP/NFKB1/MAPK10/MLX/AKT2/CREB1/TBC1D4/IKBKB/G6PC3/MAPK8/CREB5/NR1H3/PPARA/SLC27A3/RPS6KB1/PTEN/SLC27A4/SLC27A1/SOCS3/PYGB/SREBF1/PPP1R3C/PPP1R3D/CD36/CRTC2/PIK3CD/OGT/RPS6KA2/AGT/MTOR/CPT1A/PPP1R3E/PYGM/TRIB3/PIK3R2/PRKAA2	5.24130490101248
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	100/2910	212/9376	1.51980807884329	PDGFRA/RASGRP2/PDGFRB/RAP1B/RRAS/F2R/VEGFA/SIPA1L2/LPAR1/ACTG1/MRAS/THBS1/PIK3R1/PDGFD/ADCY1/AKT3/MAPK14/INSR/IGF1R/APBB1IP/CALM2/FGF2/GNAI2/EGFR/FGF7/MAGI3/CNR1/ADCY3/MAGI1/RAP1A/BCAR1/TLN2/DOCK4/VEGFB/TLN1/PFN2/PRKCA/SRC/PIK3CA/MAPK1/CRK/RALA/KDR/PDGFC/EFNA5/AKT2/VEGFC/ITGB3/CSF1/KRIT1/RAF1/IGF1/GNAO1/MAP2K1/MAP2K2/KRAS/PRKCI/EVL/P2RY1/ITGB2/GNAQ/FGF10/ADCY7/SIPA1/LCP2/ITGB1/PARD6G/PRKD1/RALGDS/PRKD2/PLCE1/ADORA2B/RHOA/VAV1/ENAH/ADCY9/PIK3CD/PLCG1/RAC2/MAGI2/ITGAM/F2RL3/PDGFA/PLCB2/ITGAL/EPHA2/LPAR5/RASSF5/ARAP3/MAPK12/MAPK11/LAT/ADCY6/TEK/ANGPT2/PARD6A/SKAP1/KITLG/PIK3R2/PFN4	5.13549957685697
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	57/2910	105/9376	1.74908198330879	BNIP3L/RRAS/MRAS/MAP1LC3A/MITF/GABARAP/GABARAPL1/OPTN/CALCOCO2/JUN/AMFR/CCZ1/PINK1/GABARAPL2/NBR1/BCL2L1/RELA/ULK1/BECN1/HIF1A/SRC/RAB7A/TFE3/RRAS2/CSNK2A1/RAB5C/TBC1D15/RAB5A/MAPK10/USP8/MUL1/MAPK8/MON1B/KRAS/MFN1/FUNDC1/FKBP8/TAX1BP1/RAB5B/ARIH1/TBC1D17/SMURF2/RHOT1/CITED2/SQSTM1/MAP1LC3B/MFN2/EIF2AK3/FOXO3/MON1A/SP1/TOMM40L/NLRX1/FIS1/AMBRA1/MTX3/USP30	5.17815436817156
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	90/2910	187/9376	1.55069187937593	IFI16/ANTXR1/TXNIP/CTSB/MAP1LC3A/PKN1/MAPK14/STAT1/IFNAR1/GABARAP/TXN/GABARAPL1/ANTXR2/CARD16/JAK1/JUN/GBP1/MYD88/FADD/CARD9/GBP3/BCL2/GABARAPL2/NLRP1/BIRC2/BCL2L1/RELA/TANK/SHARPIN/RNASEL/MAPK1/NAMPT/STAT2/TP53BP1/XIAP/OAS2/IKBKG/GBP2/CASP1/NFKB1/MAPK10/ITPR2/OAS1/IKBKB/MAPK8/MAP3K7/TRIP6/MFN1/GPSM3/GBP4/IL18/PKN2/TRAF3/CARD6/PYCARD/TLR4/TRPM7/RIPK2/MAVS/NAIP/IRAK4/CAMP/TAB2/MAP1LC3B/PANX1/RIPK1/MFN2/ATG16L1/BIRC3/TRAF5/TRAF6/CHUK/RHOA/TICAM1/GBP5/IRF9/NOD1/MCU/PLCB2/NLRX1/CYBB/P2RX7/IKBKE/TRPV2/TAB3/MAPK12/CYBA/MAPK11/PSTPIP1/TYK2	5.10281275460956
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	64/2910	122/9376	1.69022590276604	FOXO1/WNT4/ACTG1/ESR1/NCOR1/PIK3R1/RHEB/AKT3/STAT1/ITGAV/PRKACB/PLCD3/CREBBP/ATP2A2/PLCD1/MED13L/PRKCA/THRA/HIF1A/SRC/PIK3CA/MAPK1/PDPK1/PRKACA/MED27/AKT2/DIO3/BMP4/ITGB3/RAF1/TBC1D4/MAP2K1/MAP2K2/KRAS/MED13/NCOA1/NOTCH2/BAD/RXRB/HDAC3/PFKM/RCAN1/MED1/MYC/NOTCH1/MED17/RCAN2/NOTCH3/ATP1B3/PLCE1/MED14/PIK3CD/PLN/PLCG1/SIN3A/MTOR/TSC2/NOTCH4/PLCB2/KAT2B/PLCG2/PFKFB2/PIK3R2/SLC16A10	5.14778859965518
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	46/2910	80/9376	1.85264604810997	AXL/PDGFRA/PDGFRB/VEGFA/PIK3R1/STAT3/PDGFD/AKT3/IGF1R/FGF2/EGFR/JAK1/BCL2/GAS6/BCL2L1/PRKCA/SHC1/SRC/PIK3CA/MAPK1/SHC2/IL6R/KDR/PDGFC/AKT2/RAF1/IGF1/MAP2K1/MAP2K2/KRAS/ARAF/BAD/SOS2/RPS6KB1/PTEN/JAK2/SOS1/FOXO3/BCL2L11/PIK3CD/PLCG1/PDGFA/MTOR/PLCG2/SHC3/PIK3R2	5.13783321498681
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	38/2910	62/9376	1.97476998115508	TLE2/NCOR2/RFNG/ATXN1/LFNG/PSENEN/CREBBP/APH1A/NUMBL/CTBP2/RBPJ/DTX3L/APH1B/DLL1/MAML2/SNW1/DTX3/NOTCH2/TLE4/DTX1/TLE6/PSEN1/DVL2/SPEN/MAML1/NOTCH1/NUMB/PSEN2/ATXN1L/NOTCH3/MAML3/NOTCH4/KAT2B/MFNG/HES1/HEYL/JAG1/PTCRA	5.16587813475391
Organismal Systems	Immune system	hsa04611	Platelet activation	65/2910	126/9376	1.66213931162385	RASGRP2/RAP1B/FYN/F2R/ACTG1/PIK3R1/ROCK2/ADCY1/LYN/AKT3/MAPK14/TBXA2R/APBB1IP/PRKACB/GNAI2/ADCY3/FERMT3/STIM1/RAP1A/TLN2/SNAP23/PTGIR/MYLK/TLN1/SRC/PIK3CA/ARHGEF12/MAPK1/GNA13/PRKACA/ITPR2/ARHGAP35/AKT2/ITGB3/PPP1R12A/PRKCI/ROCK1/P2RY1/TBXAS1/GNAQ/ADCY7/LCP2/SYK/FCGR2A/ITGB1/ITGA2/RHOA/PTGS1/BTK/ADCY9/PIK3CD/F2RL3/PIK3R5/FGG/PLCB2/PRKG1/MAPK12/MAPK11/MYL12B/PLCG2/FCER1G/ADCY6/GUCY1A2/PIK3CG/PIK3R2	5.01970345834842
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	114/2910	253/9376	1.45180717982152	C3/FOXO1/CD44/MYL9/ACTG1/CAPN2/PIK3R1/UBE2D1/IL1R1/MAP1LC3A/ROCK2/TNFRSF1A/CAST/RRAGA/AKT3/MAPK14/EGFR/CALCOCO2/PLCD3/FBXW11/JUN/ILK/TRADD/VCL/CYTH2/CAPNS1/MYD88/BCAR1/TLN2/BCL2/WIPI1/WASF2/TLN1/WASL/BCL2L1/RELA/PLCD1/ARHGEF2/PFN2/BECN1/SHARPIN/SRC/ARF1/FNBP1/PIK3CA/MAPK1/UBE2V2/CRK/IKBKG/CASP1/WASF1/TNIP1/CTTN/NFKB1/MAPK10/ITPR2/AKT2/MALT1/WIPI2/PTK2/IKBKB/MAPK8/RRAGC/MYL5/MAP3K7/RRAGB/IL18/ROCK1/AKT1S1/RRAGD/GSK3A/RPS6KB1/ATM/PYCARD/TLR4/UBE2D4/RIPK2/U2AF1L4/NAIP/TAB2/SQSTM1/MAP1LC3B/ATG14/RIPK1/ITGB1/ATG16L1/PIK3C3/DOCK1/TRAF5/FOXO3/TRAF6/PLCE1/CHUK/RHOA/CYTH1/CYTH4/CD14/PIK3CD/TLR5/NOD1/ELMO2/PLCG1/PIK3R4/MTOR/PLCB2/UBE2D3/TAB3/MAPK12/MAPK11/HK3/MYL12B/PLCG2/PIK3R2/PFN4	4.88718561559898
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	51/2910	93/9376	1.76689945682297	GADD45G/LAMA4/PIK3R1/AKT3/ITGAV/LAMB2/LAMC1/COL4A4/BCL2/POLK/BIRC2/BCL2L1/RELA/CDK4/CDKN2B/RB1/MAX/PIK3CA/XIAP/IKBKG/NFKB1/AKT2/LAMB1/PTK2/IKBKB/CDKN1B/ITGA3/RXRB/LAMC3/TRAF3/PTEN/LAMA3/MYC/ITGB1/BIRC3/COL4A6/TRAF5/ITGA2/TRAF6/DDB2/CHUK/COL4A3/GADD45B/COL4A5/ZBTB17/CDKN1A/PIK3CD/GADD45A/LAMB3/PIK3R2/TRAF1	4.98597402623304
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	82/2910	170/9376	1.5541378613301	NFE2L2/WNT4/GSTT1/ACTG1/GADD45G/WNT5A/PIK3R1/AKT3/GSTM3/TGFBR2/WNT5B/IGF1R/MGST1/EGFR/TGFBR1/SMARCE1/PBRM1/TXNRD2/POLK/SMARCC2/BCL2L1/CDK4/RB1/PRKCA/SHC1/SMAD2/TCF7L2/WNT9A/PIK3CA/MAPK1/KEAP1/SHC2/SMARCD1/WNT2/APC/AKT2/SMAD4/RAF1/FZD2/MAP2K1/MAP2K2/KRAS/TXNRD1/ARAF/SMARCD3/BAD/WNT6/SOS2/SMAD3/RPS6KB1/PTEN/DVL2/NQO1/CSNK1A1/TGFB2/GSTM5/MYC/PHF10/SOS1/ARID1B/GSTO1/ELK1/DDB2/FZD3/LRP6/GADD45B/CDKN1A/PIK3CD/PLCG1/WNT3/MTOR/FZD10/GADD45A/FZD1/FZD4/TGFB3/FZD8/TXNRD3/PLCG2/SHC3/PIK3R2/FRAT1	4.89126375483801
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	83/2910	174/9376	1.53692775605324	NFE2L2/MAP3K5/CAPN2/UBE2D1/BAG2/SEC62/UBXN6/DNAJC3/SEC31A/SEC63/MBTPS1/SAR1B/ERN1/DNAJC1/AMFR/DERL1/MAN1A1/DNAJC10/SEL1L/SEC23A/BCAP29/BCL2/DNAJB12/ERLEC1/OS9/UBXN2A/DERL2/STUB1/UGGT2/RNF5/SEC61A1/UBQLN1/SSR1/HERPUD1/EDEM3/HSPBP1/TRAM1/MAPK10/UBE2G2/CRYAB/ATF6B/RPN1/UBE2J1/SEC61B/SIL1/UBXN1/MAPK8/HYOU1/SEC13/SEC24D/ATXN3/DNAJB2/BAG1/PLAA/FBXO6/HSP90B1/UBQLN2/MAN1C1/SSR2/SYVN1/UBE2D4/MAP2K7/DAD1/PPP1R15A/DNAJC5/XBP1/EIF2AK3/HSPA1A/TXNDC5/RNF185/UBXN4/SEC24B/UBQLN4/KRTCAP2/SSR4/UBE2D3/SEC61A2/OSTC/HSPA1B/HSPA6/SEC61G/YOD1/DNAJB1	4.79582853374329
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	41/2910	71/9376	1.86058758046561	PRLR/SOCS2/ESR1/PIK3R1/STAT3/PRL/AKT3/SOCS5/MAPK14/STAT1/RELA/CISH/SHC1/SOCS1/SRC/PIK3CA/MAPK1/SHC2/STAT5B/NFKB1/MAPK10/AKT2/RAF1/MAP2K1/SOCS4/MAP2K2/MAPK8/CCND2/KRAS/SOS2/SOCS6/JAK2/SOCS3/SOS1/FOXO3/PIK3CD/STAT5A/MAPK12/MAPK11/SHC3/PIK3R2	4.88292824645278
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	98/2910	214/9376	1.47549217972187	GNG4/CFL2/HLA-B/HLA-A/HLA-C/B2M/HLA-E/PIK3R1/TNFRSF1A/HLA-F/AKT3/MAPK14/AP1S2/TNFRSF1B/CALM2/GNG11/GNAI2/FBXW11/JUN/PAK3/TRADD/FAS/MYD88/TAP1/FADD/TAPBP/TAPBPL/SAMHD1/GNB5/BCL2/GNB2/BCL2L1/RELA/PPP3CB/PRKCA/AP1M1/PPP3CC/NFATC4/PIK3CA/MAPK1/CUL5/CRK/IKBKG/LIMK1/NFKB1/GNB1/MAPK10/ITPR2/AKT2/PTK2/RAF1/GNAO1/MAP2K1/IKBKB/GNA11/MAP2K2/MAPK8/MAP3K7/KRAS/IRAK1/BID/BAD/RPS6KB1/GNG2/GNB4/GNAQ/ATM/CD4/TLR4/MAP2K7/IRAK4/TAB2/APOBEC3C/RNF7/CXCR4/RIPK1/PAK2/CFL1/TRAF5/ATR/TRAF6/CHUK/APOBEC3G/PIK3CD/TLR2/PLCG1/RAC2/MTOR/MAPK12/MAPK11/BST2/PLCG2/GNGT2/GNB3/CD247/NFATC2/PIK3R2/NFATC1	4.7202978578526
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	70/2910	142/9376	1.58830647112918	UBE2D1/KLHL13/UBE2L6/UBE2R2/UBE2E3/FBXW11/KLHL9/BIRC2/ANAPC13/STUB1/CDC27/SOCS1/KEAP1/CUL5/UBE2H/XIAP/PML/UBE2E2/CDC26/UBE3A/TRIP12/UBE2I/HERC1/UBA2/UBE2G2/UBE2W/ANAPC7/UBE2J1/CUL2/CUL3/UBE2E1/UBA1/UBE2B/PIAS1/BIRC6/CDC16/TRIM32/HERC2/RCHY1/UBE3B/UBE2M/SYVN1/SMURF2/UBE4A/UBE2D4/ANAPC16/UBA3/WWP2/RNF7/CUL7/SOCS3/BIRC3/FZR1/WWP1/UBR5/TRAF6/DDB2/UBE2QL1/PIAS3/DET1/MGRN1/PIAS2/UBE2D3/PIAS4/FBXW8/ERCC8/UBA7/NHLRC1/UBOX5/ANAPC2	4.73878652792113
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	68/2910	137/9376	1.59923746456969	CTSK/TUBA1A/MAP3K5/CTSB/CTSS/CTSC/PTPN13/ACTG1/CAPN2/DAXX/GADD45G/PIK3R1/CFLAR/SPTAN1/TNFRSF1A/AKT3/CTSO/CTSH/CTSD/PARP4/JUN/TRADD/FAS/FADD/ERN1/NTRK1/TUBA3E/BCL2/BIRC2/BCL2L1/RELA/PIK3CA/MAPK1/XIAP/PDPK1/HTRA2/IKBKG/NFKB1/MAPK10/ITPR2/AKT2/RAF1/MAP2K1/CTSF/IKBKB/MAP2K2/MAPK8/PARP3/KRAS/BID/CTSZ/BAD/ATM/RIPK1/BIRC3/EIF2AK3/CHUK/BCL2L11/GADD45B/LMNA/PIK3CD/CASP10/GADD45A/TUBA3D/MCL1/TUBA4A/PIK3R2/TRAF1	4.73981117312317
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	55/2910	105/9376	1.68771068564883	GADD45G/VCAM1/IL1R1/CXCL12/CFLAR/TNFRSF1A/PLAU/LYN/RELB/TRADD/MYD88/BCL2/BIRC2/BCL2L1/RELA/CYLD/LTBR/XIAP/CSNK2A1/IKBKG/UBE2I/TNFSF13B/NFKB1/MALT1/TRIM25/IKBKB/NFKB2/MAP3K7/LY96/IRAK1/TRAF3/ATM/TLR4/CD40/IRAK4/TAB2/SYK/RIPK1/BIRC3/TRAF5/TRAF6/CHUK/GADD45B/TICAM1/BTK/CD14/PLCG1/ICAM1/GADD45A/PIAS4/TAB3/LAT/TNFSF14/PLCG2/TRAF1	4.75391501902242
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	34/2910	56/9376	1.95621011291114	GAS1/SCUBE2/PRKACB/SPOP/FBXW11/GPR161/BCL2/CSNK1E/BOC/CSNK1D/CSNK1G3/PRKACA/CUL3/CCND2/CSNK1G2/KIF3A/MEGF8/PTCH1/IQCE/SMURF2/CSNK1A1/CSNK1G1/GLI2/EVC/DISP1/EFCAB7/ARRB2/EVC2/SPOPL/SUFU/SMO/MGRN1/KIF7/CDON	4.8145275076725
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	68/2910	138/9376	1.5876487872902	FOXO1/IRS2/SOCS2/IRS1/PIK3R1/RHOQ/RHEB/AKT3/INSR/PRKACB/CALM2/TRIP10/SORBS1/PRKAR1A/FLOT1/ACACB/EXOC7/SHC1/PRKAG1/SOCS1/PIK3CA/MAPK1/PRKAA1/PDPK1/PTPN1/SHC2/CRK/PRKAR2A/PRKAG2/PRKACA/MAPK10/AKT2/RAF1/MAP2K1/IKBKB/FBP1/SOCS4/MAP2K2/G6PC3/MAPK8/KRAS/ARAF/PRKAR2B/PRKCI/BAD/SOS2/RPS6KB1/SOCS3/PYGB/SOS1/SREBF1/PPP1R3C/ELK1/PPP1R3D/PIK3CD/INPPL1/MTOR/TSC2/HK3/PPP1R3F/LIPE/PRKAR1B/PPP1R3E/PYGM/PDE3B/SHC3/PIK3R2/PRKAA2	4.66533346181653
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	75/2910	157/9376	1.53916869131263	FOXO1/ZFP36L2/RRAS/SERPINE1/HLA-B/CHEK2/HLA-A/HLA-C/CAPN2/HLA-E/MRAS/GADD45G/IGFBP3/PIK3R1/NBN/RHEB/HLA-F/AKT3/MAPK14/TGFBR2/MAPKAPK2/CALM2/FBXW11/TGFBR1/RAD50/ETS1/RELA/HIPK3/CDK4/CDKN2B/PPP3CB/RB1/PPP3CC/SMAD2/NFATC4/PIK3CA/MAPK1/RRAS2/TRAF3IP2/HIPK2/NFKB1/ITPR2/AKT2/RBL2/RAF1/MAP2K1/MAP2K2/CCND2/KRAS/HUS1/SMAD3/ATM/PTEN/TRPM7/TGFB2/SQSTM1/MYC/FOXO3/ATR/LIN52/GADD45B/CDKN1A/PIK3CD/MTOR/TSC2/MCU/GADD45A/SIRT1/TGFB3/RASSF5/MAPK12/MAPK11/NFATC2/PIK3R2/NFATC1	4.57032271090808
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	43/2910	78/9376	1.77622698035069	PIP5K1C/ITPK1/PLCD3/PLCD1/MINPP1/PI4K2A/CDIPT/INPP1/PIK3CA/MTMR6/ITPKC/INPP4B/IP6K2/SACM1L/PIP4K2A/PPIP5K2/IP6K3/INPP5K/PIP4K2B/MTMR3/PTEN/FIG4/ALDH6A1/PIK3C3/IP6K1/PI4KB/MTMR2/OCRL/ITPKB/PLCE1/INPP4A/PIK3CD/PLCG1/INPPL1/PIKFYVE/PLCB2/INPP5E/PIP5K1B/MTM1/ITPKA/SYNJ2/PLCG2/PIK3CG	4.61801720914622
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	79/2910	168/9376	1.5151039109802	PRLR/PDGFRA/PDGFRB/IFNGR2/IL15/SOCS2/FHL1/IL13RA1/PIK3R1/PIM1/IL15RA/STAT3/PRL/OSMR/AKT3/SOCS5/STAT1/IFNAR1/CLCF1/AOX1/EGFR/IL6ST/JAK1/IFNGR1/PTPN11/CREBBP/BCL2/STAM/IL4R/BCL2L1/CISH/STAM2/SOCS1/CTF1/PIK3CA/STAT2/STAT5B/IL6R/AKT2/STAT6/RAF1/SOCS4/CCND2/PIAS1/IL13RA2/SOS2/SOCS6/JAK2/IL11/MYC/SOCS3/SOS1/IL19/EPOR/CSH1/IL2RA/CDKN1A/LEPR/PIK3CD/IRF9/PIAS3/STAT5A/IL2RG/PDGFA/MTOR/THPO/IL12RB1/IL10/PIAS2/IL27RA/PIAS4/JAK3/MCL1/CSH2/TYK2/OSM/PIK3R2/STAT4/LIF	4.5194034772847
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	54/2910	105/9376	1.65702503681885	RRAS/MRAS/PIK3R1/AKT3/MAPK14/STAT1/MAPKAPK2/CALM2/RELB/JUN/LSP1/PTPN11/CARD9/RELA/PPP3CB/PPP3CC/CYLD/PLK3/SRC/NFATC4/PIK3CA/ARHGEF12/MAPK1/RRAS2/STAT2/IKBKG/CASP1/NFKB1/MAPK10/ITPR2/AKT2/MALT1/RAF1/IKBKB/MAPK8/NFKB2/BCL3/KRAS/PYCARD/CLEC4M/SYK/CHUK/RHOA/PIK3CD/IRF9/IL10/IKBKE/MAPK12/MAPK11/PLCG2/FCER1G/NFATC2/PIK3R2/NFATC1	4.54179534444785
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	103/2910	232/9376	1.43045384524233	PDGFRA/CFL2/ITGB5/PDGFRB/GSN/RRAS/ITGB8/F2R/RGCC/MYL9/PIP5K1C/LPAR1/ACTG1/TMSB4X/MRAS/MSN/PIK3R1/CXCL12/ROCK2/PDGFD/AKT3/ITGAV/FGF2/BDKRB2/EGFR/FGF7/PAK3/VCL/ITGAE/BCAR1/ABI2/WASF2/MYLK/WASL/PFN2/BRK1/SRC/PIK3CA/ARHGEF12/MAPK1/RRAS2/BDKRB1/GNA13/CRK/SSH1/LIMK1/APC/WASF1/PDGFC/ARHGAP35/AKT2/ITGB3/PTK2/RAF1/MAP2K1/ITGA1/MAP2K2/DIAPH2/PIP4K2A/MYL5/KRAS/PPP1R12A/ARAF/ROCK1/ITGA3/SOS2/ITGB2/PIP4K2B/NCKAP1L/MYH11/FGF10/MYH9/BAIAP2/PPP1R12C/CXCR4/ITGB1/PAK2/CFL1/SOS1/DOCK1/ARHGEF7/PPP1R12B/ARHGEF6/ITGA2/RHOA/VAV1/ENAH/PIK3CD/PIKFYVE/RAC2/ITGAM/ITGAX/PDGFA/ITGA4/ITGAL/FGD1/PIP5K1B/LPAR5/ITGAD/MYL12B/C5/PIK3R2/PFN4	4.45365691169522
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	46/2910	86/9376	1.72339167266043	PIK3R1/AKT3/ABL1/EGFR/JUN/PAK3/NCK1/PRKCA/SHC1/SRC/PIK3CA/MAPK1/SHC2/CRK/STAT5B/MAPK10/AKT2/PTK2/RAF1/MAP2K1/MAP2K2/MAPK8/CDKN1B/KRAS/ARAF/CAMK2D/BAD/SOS2/RPS6KB1/ABL2/MAP2K7/MYC/NCK2/PAK2/SOS1/ELK1/MAP2K4/CDKN1A/PIK3CD/STAT5A/PLCG1/MTOR/HBEGF/PLCG2/SHC3/PIK3R2	4.52094429868122
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	39/2910	70/9376	1.79511045655376	IRS2/IRS1/STAT3/TNFRSF1A/AKT3/TNFRSF1B/TRADD/PTPN11/RELA/ACACB/ACSL3/PRKAG1/PRKAA1/ACSL1/IKBKG/PRKAG2/CAMKK2/NFKB1/MAPK10/AKT2/APPL1/CPT1C/IKBKB/G6PC3/MAPK8/PPARA/STK11/RXRB/JAK2/SOCS3/CD36/CHUK/NFKBIE/LEPR/MTOR/POMC/CPT1A/ACSL5/PRKAA2	4.47929064743545
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	55/2910	109/9376	1.6257763485608	CTSK/PIK3R1/AKT3/MAPK14/STAT1/IFNAR1/JAK1/JUN/MYD88/FADD/RELA/TOLLIP/PIK3CA/MAPK1/STAT2/IKBKG/SPP1/NFKB1/MAPK10/AKT2/MAP2K1/IKBKB/MAP2K2/MAPK8/MAP3K7/LY96/IRAK1/CD86/TRAF3/TLR4/MAP2K7/CD40/IRAK4/TAB2/RIPK1/CXCL10/TRAF6/TLR1/TLR7/CXCL9/CHUK/TICAM1/MAP2K4/CD14/PIK3CD/IRF9/TLR5/TLR2/IRF5/IKBKE/MAPK12/MAPK11/TYK2/TLR6/PIK3R2	4.40836042357843
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	73/2910	155/9376	1.51745482762443	RAP1B/WNT4/WNT5A/KCNK3/ADCY1/WNT5B/PDE8B/PRKACB/GNAI2/EGFR/KMT2A/CREB3/ADCY3/CREB3L2/CREB3L1/RAP1A/CDK4/CDKN2B/RB1/PBX1/TCF7L2/PDE8A/WNT9A/MAPK1/AIP/WNT2/APC/PRKACA/ATF2/ITPR2/USP8/ATF6B/CREB1/FZD2/MAP2K1/GNA11/MAP2K2/CREB5/CDKN1B/CAMK2D/WNT6/GNAQ/ADCY7/SCARB1/NCEH1/DVL2/STAR/LDLR/RBBP5/CDKN2C/AGTR1/WDR5B/CACNA1G/ARMC5/SP1/FZD3/RASD1/ADCY9/AHR/CDKN1A/MEN1/AGT/WNT3/POMC/FZD10/PLCB2/FZD1/CACNA1C/FZD4/FZD8/KMT2D/CACNA1H/ADCY6	4.35776256414958
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	38/2910	68/9376	1.80052557105316	PIK3R1/PIM1/STAT3/AKT3/RELA/TCF7L2/PIK3CA/MAPK1/PML/IKBKG/RARA/ZBTB16/STAT5B/RUNX1T1/NFKB1/AKT2/RAF1/MAP2K1/IKBKB/MAP2K2/KRAS/ARAF/BAD/SOS2/RPS6KB1/SPI1/PER2/MYC/FCGR1A/SOS1/RUNX1/CHUK/CD14/PIK3CD/STAT5A/ITGAM/MTOR/PIK3R2	4.44442683005542
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	90/2910	200/9376	1.44989690721649	TUBA1A/FYN/F2R/LPAR1/ACTG1/IL1R1/ROCK2/TJP1/TNFRSF1A/MAPK14/ABL1/JUN/PAK3/TRADD/FAS/CYTH2/MYD88/FADD/PTPN11/NCK1/TUBA3E/WASF2/WASL/RELA/MYO5A/TUBB2A/ARHGEF2/MYO1C/MYO6/BRK1/SRC/MYO1E/ARF1/ARHGEF12/MAPK1/GNA13/IKBKG/CASP1/ABCF2/ABI1/WASF1/CTTN/NFKB1/MAPK10/IKBKB/MAPK8/MAP3K7/SEC24D/IRAK1/IL18/ROCK1/NCKAP1L/MYH11/PYCARD/MYH9/TLR4/NAIP/IRAK4/TAB2/CLDN10/WIPF3/BAIAP2/FCGR2A/NCK2/WIPF2/RIPK1/ITGB1/PAK2/ARHGEF11/CLDN23/TRAF6/CHUK/SEC24B/RHOA/WASF3/MYO1F/TMED10/CYTH1/CYTH4/TLR5/TUBB2B/TUBA3D/LPAR5/TAB3/CLDN12/MAPK12/MAPK11/TUBA4A/MYO1D/CLDN15	4.3143521002845
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	60/2910	122/9376	1.58458678384316	FOXO1/IRS2/CAB39L/IRS1/PIK3R1/RHEB/AKT3/INSR/IGF1R/CREB3/CREB3L2/CREB3L1/PPP2R3C/CAB39/ULK1/ACACB/RAB14/RAB11B/PPP2R5E/PRKAG1/TBC1D1/PIK3CA/PRKAA1/PDPK1/PPP2CB/PRKAG2/CAMKK2/AKT2/PPP2CA/CREB1/PPP2R5B/CPT1C/IGF1/FBP1/G6PC3/CREB5/MAP3K7/STK11/PPP2R2D/AKT1S1/RPS6KB1/PFKM/PFKFB3/MLYCD/SREBF1/PPP2R3A/FOXO3/CD36/CRTC2/LEPR/PIK3CD/SCD5/MTOR/TSC2/SIRT1/CPT1A/LIPE/PFKFB2/PIK3R2/PRKAA2	4.35991922255773
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	40/2910	73/9376	1.76547568610836	GADD45G/PIK3R1/STAT3/AKT3/EGFR/KIF5B/POLK/CDK4/RB1/PRKCA/PIK3CA/MAPK1/PDPK1/STAT5B/AKT2/RAF1/MAP2K1/MAP2K2/RASSF1/KRAS/ARAF/BAD/RXRB/SOS2/STK4/KIF5A/SOS1/FOXO3/DDB2/GADD45B/CDKN1A/PIK3CD/STAT5A/PLCG1/GADD45A/RASSF5/JAK3/KIF5C/PLCG2/PIK3R2	4.40448974187607
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	67/2910	140/9376	1.54195385370643	SPHK1/GNG4/PLAT/RRAS/SERPINE1/MRAS/MAP1LC3A/ADCY1/AKT3/PRKACB/MEF2A/CALM2/GNG11/GNAI2/TGFBR1/ADCY3/GNB5/MYLK/GNB2/BECN1/PRKAG1/SMAD2/MAPK1/RRAS2/PRKAA1/GNA13/PRKAG2/PRKACA/SPP1/GNB1/MEF2D/ITPR2/AKT2/SLC8A1/SMAD4/RAF1/MAP2K1/MAP2K2/KRAS/SMAD3/RPS6KB1/GNG2/GNB4/GNAQ/ADCY7/HDAC4/MAP1LC3B/AGTR1/ACTA2/PIK3C3/NOTCH3/SPHK2/ADCY9/MEF2C/PIK3R4/MTOR/PIK3R5/PLCB2/LIPE/GNGT2/ADCY6/PIK3CG/PDE3B/GNB3/JAG1/NRF1/PRKAA2	4.33409720136558
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	104/2910	238/9376	1.40792976984608	GNG4/PDGFRA/RASGRP2/PDGFRB/RAP1B/RRAS/VEGFA/MRAS/PIK3R1/PDGFD/AKT3/INSR/IGF1R/ABL1/PRKACB/CALM2/FGF2/GNG11/EGFR/FGF7/PAK3/PLD1/RASA3/SHOC2/NTRK1/PTPN11/RAP1A/GNB5/VEGFB/ETS1/RIN1/GNB2/BCL2L1/RELA/PRKCA/SHC1/ETS2/PIK3CA/MAPK1/RRAS2/SHC2/RALGAPA1/IKBKG/RAB5C/RALA/RASAL2/RAB5A/PRKACA/NFKB1/GNB1/KDR/PDGFC/MAPK10/EFNA5/AKT2/VEGFC/CSF1/RAF1/IGF1/MAP2K1/IKBKB/MAP2K2/MAPK8/RASSF1/KRAS/SYNGAP1/BAD/SOS2/RAB5B/STK4/GNG2/GAB2/GNB4/RASA2/FGF10/FLT3LG/ABL2/RALGAPB/PAK2/SOS1/ELK1/RALGDS/PLCE1/CHUK/RHOA/PIK3CD/PLCG1/NTRK2/RAC2/PDGFA/EXOC2/RASA4/EPHA2/RASSF5/RASAL3/LAT/PLCG2/GNGT2/TEK/ANGPT2/GNB3/SHC3/KITLG/PIK3R2	4.27624505109503
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	57/2910	115/9376	1.59698789780368	AKAP13/ADCY1/PRKACB/MEF2A/GNAI2/EGFR/MMP14/PLD1/MAFB/CREB3/ADCY3/CREB3L2/CREB3L1/WNK1/BCL2/PDE4B/PRKCA/MMP17/MAPK1/GNA13/OXSR1/PRKACA/ATF2/MEF2D/ITPR2/ATF6B/CREB1/RAF1/JUND/MAP2K1/GNA11/STK39/CREB5/ARAF/RXRB/WNK3/PDE4A/PTHLH/GNAQ/ADCY7/SGK1/VDR/ARHGEF11/SP1/LRP6/ARRB2/RHOA/ADCY9/CDKN1A/MEF2C/RUNX2/WNK2/PLCB2/HBEGF/NR4A2/KL/ADCY6	4.32115443324908
NA	NA	hsa04517	IgSF CAM signaling	126/2910	299/9376	1.35776299003551	FOXO1/TUBA1A/PMP22/CLMP/RAP1B/FYN/MYL9/MYL6/ACTG1/MSN/PIK3R1/TJP1/PPFIA1/SPTAN1/LRFN4/LYN/JAM2/AKT3/MAPK14/ABL1/NLGN4X/MBP/PLXNA4/SPTBN1/PAK3/UNC5B/VCL/MAGI1/PTPN11/SORBS1/DOK1/RAP1A/NCK1/EPB41L2/BCAR1/TUBA3E/TRPC6/MYLK/WASL/TUBB2A/PRKCA/CADM4/SRC/CDH2/PIK3CA/CD84/MAPK1/NLGN2/PDPK1/CASK/MYL6B/KDR/MAPK10/SRGAP1/AKT2/ICAM2/CXADR/ITGB3/PTK2/CSK/MAP2K1/MAP2K2/MAPK8/CD86/PTPRD/PRKCI/NRP1/ITGB2/MYH11/SLIT3/MYH9/LCP2/NLGN1/CLEC4M/CD226/CD48/APP/SLITRK4/BAIAP2/CNTN1/NCK2/ITGB1/PAK2/PARD6G/DOK2/TRAF6/NCAM1/RHOA/VAV1/PIK3CD/PLCG1/PLXNA1/NCAM2/MAGI2/ITGAM/CADM1/ITGAX/EPB41L1/FGG/ITGA4/ICAM1/TUBB2B/ITGAL/CASKIN2/CD2/TUBA3D/LRFN5/CRTAM/MAPK12/SLAMF7/MAPK11/ROBO2/MYL12B/PPFIA2/PLCG2/ANK2/NFASC/SRGAP3/CNTNAP1/PARD6A/TUBA4A/CD96/PIK3R2/CABLES2/CABLES1/UNC5C	4.21768480022363
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	35/2910	62/9376	1.818867087906	FOXO1/IRS2/IRS1/PIK3R1/ADCY1/AKT3/INSR/IGF1R/PRKACB/SOD2/ADCY3/CAT/PRKAG1/PIK3CA/PRKAA1/PRKAG2/PRKACA/CRYAB/AKT2/IGF1/KRAS/AKT1S1/RPS6KB1/ADCY7/HSPA1A/FOXO3/ADCY9/PIK3CD/MTOR/SIRT1/ADCY6/HSPA1B/HSPA6/PIK3R2/PRKAA2	4.33965721807573
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	68/2910	144/9376	1.52149675448645	C3/FOXO1/MAP3K5/C2/ALDH9A1/TNFRSF1A/AKT3/MAPK14/TRADD/FAS/MYD88/FADD/C1QB/IL17RC/RELA/ACACB/C1QA/PRKAG1/LPIN1/TCF7L2/PRKAA1/IKBKG/PRKAG2/CAMKK2/NFKB1/MAPK10/AKT2/CPT1C/ACADM/IKBKB/MAPK8/LPIN2/C1QC/MAP3K7/PPARA/LY96/C3AR1/IRAK1/ADH1B/ALDH3A2/TRAF3/TLR4/MAP2K7/IRAK4/TAB2/MLYCD/RIPK1/SREBF1/FOXO3/TRAF6/CHUK/ADH5/TICAM1/MAP2K4/IL17RA/LPIN3/NOX4/CD14/SCD5/SIRT1/CPT1A/IKBKE/TAB3/MAPK12/MAPK11/C5AR1/C5/PRKAA2	4.23057346077559
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	27/2910	44/9376	1.97713214620431	PRKACB/STX4/DYNC2LI1/DCTN2/CREB3/ADCY3/CREB3L2/CREB3L1/DYNC1H1/VAMP2/DYNC1LI1/DCTN6/ARHGDIA/DYNC2H1/RAB11B/DYNC1I2/RAB5C/DYNC1LI2/RAB5A/PRKACA/CREB1/DCTN1/CREB5/RAB5B/ADCY9/AQP3/ADCY6	4.35819398437818
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	95/2910	216/9376	1.4170803105511	NFE2L2/RAP1B/MAP3K5/APOA1/VCAM1/PIK3R1/ROCK2/STAT3/TNFRSF1A/LYN/AKT3/MAPK14/CALM2/JUN/FAS/ABCA1/SOD2/MYD88/ERN1/RAP1A/BCL2/BCL2L1/RELA/TANK/PPP3CB/PRKCA/PPP3CC/SRC/PIK3CA/MAPK1/PDPK1/IKBKG/CASP1/NFKB1/MAPK10/AKT2/PTK2/IKBKB/MAPK8/MAP3K7/KRAS/MIB1/LY96/IRAK1/BID/CAMK2D/IL18/NCF2/BAD/RXRB/HSP90B1/TRAF3/JAK2/PYCARD/TLR4/MAP2K7/CD40/IRAK4/LDLR/TAB2/MMP1/XBP1/EIF2AK3/HSPA1A/MIB2/MMP9/CYP2A6/TRAF6/CD36/CHUK/CYP2A7/RHOA/VAV1/TICAM1/MAP2K4/CD14/PIK3CD/TLR2/PLCG1/ABCG1/POU2F2/ICAM1/PLCB2/MMP3/CYBB/IKBKE/MAPK12/CYBA/MAPK11/HSPA1B/HSPA6/TLR6/NFATC2/PIK3R2/NFATC1	4.16018946160181
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	50/2910	99/9376	1.62726925613524	PDGFRA/PDGFRB/PIP5K1C/PIK3R1/PDGFD/RHEB/AKT3/EGFR/JUN/PLD1/CHPT1/PCYT1A/WASF2/GPCPD1/PRKCA/HIF1A/PIK3CA/MAPK1/PDPK1/WASF1/PDGFC/MAPK10/AKT2/DGKH/RAF1/MAP2K1/MAP2K2/MAPK8/KRAS/SLC22A4/DGKE/SOS2/RPS6KB1/CHKB/SOS1/RALGDS/SP1/WASF3/DGKA/PIK3CD/PLCG1/RAC2/PDGFA/MTOR/TSC2/PIP5K1B/CHKA/DGKQ/DGKD/PIK3R2	4.20903080116934
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	89/2910	201/9376	1.42665367321468	FOXO1/PLAT/ZEB1/WT1/MEIS1/PBX3/GADD45G/KLF3/IGFBP3/NCOR1/MAF/NUPR1/PLAU/TGFBR2/MITF/IGF1R/CDK14/HOXA10/HOXA11/KMT2A/JMJD1C/CDK9/HOXA9/NTRK1/POLK/BIRC2/BCL2L1/RELA/PBX1/MAX/TFE3/PML/BMI1/RARA/ZBTB16/RUNX1T1/NFKB1/TSPAN7/SMAD1/PTK2/LYL1/PRCC/IGF1/ELK4/CCND2/DDX5/CDKN1B/GRIA3/FUT8/CD86/RXRB/SS18/AFF1/SPI1/ATM/CCNT2/BMP2K/CD40/IL1R2/ETV6/LDB1/CDKN2C/PER2/MYC/SUPT3H/SLC45A3/FCGR1A/BIRC3/MLLT3/RUNX1/MMP9/SP1/DDB2/GADD45B/ZBTB17/CDKN1A/CD14/MEN1/SIN3A/ITGAM/MEF2C/PDGFA/RUNX2/GADD45A/MMP3/CEBPB/ARNT2/TRAF1/PTCRA	4.10189712179271
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	86/2910	193/9376	1.43570678204512	GNG4/RASGRP2/RAP1B/PIK3R1/CXCL12/ROCK2/STAT3/ADCY1/LYN/AKT3/STAT1/GRK5/PRKACB/GNG11/GNAI2/ADCY3/RAP1A/BCAR1/GNB5/GNB2/RELA/SHC1/SRC/PIK3CA/MAPK1/STAT2/SHC2/CRK/IKBKG/STAT5B/PRKACA/NFKB1/GNB1/AKT2/PTK2/RAF1/MAP2K1/IKBKB/KRAS/GRK4/CCL8/CXCL16/ROCK1/BAD/SOS2/GSK3A/GNG2/GNB4/GNAQ/JAK2/ADCY7/CCL26/CXCR4/CXCL10/SOS1/DOCK2/FOXO3/GRK6/CXCL9/CHUK/FGR/PPBP/ARRB2/RHOA/CCL18/VAV1/ADCY9/PIK3CD/PLCG1/RAC2/HCK/PIK3R5/PLCB2/PF4/JAK3/PLCG2/GNGT2/ADCY6/PIK3CG/GNB3/SHC3/XCL2/CX3CR1/PIK3R2/CCL7/XCL1	4.10293810024946
Human Diseases	Infectious disease: viral	hsa05162	Measles	64/2910	136/9376	1.51623205983424	MSN/PIK3R1/STAT3/AKT3/STAT1/IFNAR1/JAK1/JUN/TRADD/FAS/MYD88/MX2/FADD/RAB9A/BCL2/BCL2L1/RELA/CDK4/MX1/PIK3CA/STAT2/OAS2/CSNK2A1/IKBKG/EIF2AK2/STAT5B/NFKB1/ADAR/MAPK10/AKT2/OAS1/IKBKB/MAPK8/CCND2/CDKN1B/MAP3K7/IRAK1/BID/BAD/RCHY1/TRAF3/TLR4/MAVS/CLEC4M/IRAK4/TAB2/HSPA1A/TRAF6/TLR7/IL2RA/CHUK/PIK3CD/IRF9/IFIH1/TLR2/STAT5A/IL2RG/IKBKE/JAK3/TYK2/HSPA1B/HSPA6/PIK3R2/RAB9B	4.06811033576976
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	78/2910	173/9376	1.45269054287587	IFNGR2/ACTG1/PIK3R1/TNFRSF1A/HLA-DPB1/AKT3/STAT1/IFNAR1/HLA-DQA2/CALCOCO2/DNAJC3/JAK1/TRADD/FAS/IFNGR1/MYD88/HLA-DRA/MX2/FADD/HLA-DPA1/CREBBP/HLA-DMB/RELA/CDK4/HLA-DMA/PRKCA/RAB11B/MX1/RNASEL/PIK3CA/HLA-DQA1/MAPK1/HNRNPUL1/STAT2/PML/OAS2/IKBKG/CASP1/EIF2AK2/NFKB1/ADAR/AKT2/OAS1/TRIM25/RAF1/MAP2K1/IKBKB/MAP2K2/BID/KPNA6/IL18/KPNA1/TRAF3/JAK2/KPNA5/PYCARD/HLA-DQB1/TLR4/MAVS/HLA-DOA/IRAK4/HLA-DRB1/SOCS3/CXCL10/TLR7/CHUK/TICAM1/PIK3CD/IRF9/IFIH1/CIITA/RSAD2/ICAM1/NLRX1/IKBKE/TYK2/PIK3R2/DNAJB1	4.0315685151144
Human Diseases	Cancer: specific types	hsa05214	Glioma	40/2910	76/9376	1.69578585639356	PDGFRA/PDGFRB/GADD45G/PIK3R1/AKT3/CAMK1/IGF1R/CALM2/EGFR/POLK/CDK4/RB1/PRKCA/SHC1/PIK3CA/MAPK1/SHC2/AKT2/RAF1/IGF1/MAP2K1/MAP2K2/CAMK1D/KRAS/ARAF/CAMK2D/SOS2/PTEN/SOS1/DDB2/GADD45B/CDKN1A/PIK3CD/PLCG1/PDGFA/MTOR/GADD45A/PLCG2/SHC3/PIK3R2	4.08559394103903
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	52/2910	106/9376	1.58060040199702	FOXO1/PLAT/PDGFRA/PDGFRB/ZEB1/PIK3R1/PDGFD/PLAU/AKT3/IGF1R/EGFR/CREB3/CREB3L2/CREB3L1/CREBBP/BCL2/RELA/RB1/TCF7L2/PIK3CA/MAPK1/PDPK1/IKBKG/NFKB1/PDGFC/AR/AKT2/CREB1/RAF1/IGF1/MAP2K1/IKBKB/MAP2K2/CREB5/CDKN1B/KRAS/ARAF/BAD/SOS2/HSP90B1/PTEN/IL1R2/SOS1/MMP9/CHUK/CDKN1A/PIK3CD/PDGFA/MTOR/MMP3/FOLR2/PIK3R2	4.03278139003962
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	68/2910	148/9376	1.48037522058141	WNT4/GADD45G/ESR1/WNT5A/PIK3R1/PGR/AKT3/WNT5B/IGF1R/FGF2/EGFR/FGF7/JUN/POLK/CDK4/RB1/SHC1/TCF7L2/WNT9A/PIK3CA/DLL1/MAPK1/SHC2/WNT2/APC/AKT2/RAF1/FZD2/IGF1/MAP2K1/MAP2K2/NFKB2/KRAS/NCOA1/ARAF/NOTCH2/WNT6/SOS2/RPS6KB1/FGF10/PTEN/DVL2/CSNK1A1/MYC/NOTCH1/SOS1/NOTCH3/SP1/DDB2/FZD3/LRP6/GADD45B/CDKN1A/PIK3CD/WNT3/MTOR/FZD10/NOTCH4/GADD45A/FZD1/FZD4/FZD8/HES1/HEYL/JAG1/SHC3/PIK3R2/FRAT1	3.95159060506266
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	33/2910	60/9376	1.77209621993127	SPHK1/VEGFA/PIK3R1/AKT3/MAPK14/MAPKAPK2/SH2D2A/HSPB1/PPP3CB/PRKCA/PPP3CC/SRC/PIK3CA/MAPK1/SHC2/KDR/AKT2/PTK2/RAF1/MAPKAPK3/MAP2K1/MAP2K2/KRAS/BAD/SPHK2/PIK3CD/PLCG1/RAC2/MAPK12/MAPK11/PLCG2/NFATC2/PIK3R2	4.02482121987249
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	44/2910	87/9376	1.62951376545404	GADD45G/PIK3R1/AKT3/TGFBR2/EGFR/JUN/TGFBR1/BCL2/POLK/SMAD2/TCF7L2/PIK3CA/MAPK1/APC/RALA/MAPK10/AKT2/SMAD4/APPL1/RAF1/MAP2K1/MAP2K2/MAPK8/KRAS/ARAF/BAD/SOS2/SMAD3/RPS6KB1/TGFB2/MYC/SOS1/RALGDS/DDB2/BCL2L11/RHOA/GADD45B/CDKN1A/PIK3CD/RAC2/MTOR/GADD45A/TGFB3/PIK3R2	3.95726066858002
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	70/2910	154/9376	1.46454233052171	MYL9/MYL6/ACTG1/NPR1/ROCK2/RGS2/ADCY1/CAMK1/MAPK7/PRKACB/CALM2/GNAI2/EGFR/CACNB3/JUN/ADCY3/CACNA2D1/MYLK/PPP3CB/PRKCA/PPP3CC/PRKAG1/SRC/NFATC4/MAPK1/CACNB2/PRKAA1/OXT/PRKAG2/PRKACA/CAMKK2/MYL6B/ITPR2/RAF1/GNAO1/MAP2K1/MAP2K2/CD38/CAMK1D/KRAS/PPP1R12A/CAMK2D/ROCK1/GNAQ/ADCY7/NPR2/RCAN1/OXTR/PPP1R12C/ELK1/PPP1R12B/MAP2K5/RHOA/ADCY9/CDKN1A/CACNB1/MEF2C/CACNA2D4/PIK3R5/PLCB2/CACNA1C/KCNJ5/KCNJ12/ADCY6/GUCY1A2/PIK3CG/NFATC2/KCNJ2/NFATC1/PRKAA2	3.89930654235555
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	48/2910	98/9376	1.57811908268462	PIP5K1C/PIK3R1/ITPK1/CALM2/PLCD3/PLCD1/PI4K2A/CDIPT/PRKCA/INPP1/PIK3CA/MTMR6/ITPKC/INPP4B/ITPR2/DGKH/IP6K2/SACM1L/PIP4K2A/PPIP5K2/IP6K3/DGKE/PIP4K2B/MTMR3/PTEN/PIK3C3/IP6K1/PI4KB/MTMR2/OCRL/ITPKB/PLCE1/INPP4A/DGKA/PIK3CD/PLCG1/INPPL1/PIKFYVE/PLCB2/INPP5E/PIP5K1B/MTM1/ITPKA/SYNJ2/DGKQ/PLCG2/DGKD/PIK3R2	3.85937910501236
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	42/2910	83/9376	1.63040616072538	PHC2/UBE2D1/PCGF5/PHF1/PCGF2/CREBBP/PHF19/YAF2/MAX/SFMBT2/CBX6/BMI1/DCAF7/USP16/EZH1/RING1/E2F6/KDM2A/AUTS2/PHC3/ASXL2/CBX7/ASXL1/UBE2D4/FBRS/MGA/WDR5B/SCML1/SCMH1/PCGF1/LCOR/USP7/FBRSL1/L3MBTL3/FOXK1/OGT/UBE2D3/MBD5/CBX8/ASXL3/SCML2/YY2	3.86986494584027
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	55/2910	116/9376	1.52766915511317	RAP1B/THY1/CD99/MYL9/ACTG1/MSN/VCAM1/PIK3R1/CXCL12/ROCK2/JAM2/MAPK14/GNAI2/VCL/PTPN11/MMP2/RAP1A/BCAR1/ARHGAP5/PRKCA/PIK3CA/ARHGAP35/PTK2/CD99L2/MYL5/ROCK1/NCF2/ITGB2/SIPA1/CLDN10/CXCR4/ITGB1/MMP9/CLDN23/RHOA/VAV1/PIK3CD/PLCG1/RAC2/ITGAM/ITGA4/ICAM1/ITGAL/CYBB/RASSF5/CLDN12/MAPK12/CYBA/MAPK11/MYL12B/PLCG2/PIK3R2/RHOH/CLDN15/TXK	3.83618455146474
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	35/2910	66/9376	1.708632718942	IFNGR2/MAF/STAT3/HLA-DPB1/STAT1/HLA-DQA2/JUN/IFNGR1/HLA-DRA/HLA-DPA1/HLA-DMB/IL4R/RELA/HLA-DMA/SMAD2/RORA/HLA-DQA1/NFKB1/STAT6/IL18/SMAD3/HLA-DQB1/TLR4/HLA-DOA/TGFB2/HLA-DRB1/TLR5/TLR2/IL2RG/IL12RB1/IL10/IL18R1/TGFB3/STAT4/NFATC1	3.87554345213724
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	36/2910	69/9376	1.68103989242492	FYN/PIK3R1/LYN/AKT3/MAPK14/PRKCA/PIK3CA/MAPK1/PDPK1/MAPK10/AKT2/RAF1/MAP2K1/MAP2K2/MAPK8/KRAS/SOS2/ALOX5/GAB2/MAP2K7/LCP2/SYK/SOS1/ALOX5AP/VAV1/MAP2K4/BTK/PIK3CD/PLCG1/RAC2/MAPK12/MAPK11/LAT/PLCG2/FCER1G/PIK3R2	3.80896097206336
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	21/2910	34/9376	1.99005457853244	RORB/FBXW11/FBXL3/CSNK1E/PRKAG1/CSNK1D/RORA/PRKAA1/CLOCK/PRKAG2/CRY2/CREB1/NFIL3/NR1D1/CRY1/PER1/NR1D2/PER2/PER3/NPAS2/PRKAA2	3.87965355846823
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	20/2910	32/9376	2.01374570446735	GABARAP/GABARAPL1/WIPI1/GABARAPL2/BECN1/ATG7/ULK2/PPP2CB/PPP2CA/WIPI2/ATG4A/ATG4B/ATG13/ATG16L1/PIK3C3/ATG4D/ATG2B/PIK3R4/MTOR/ATG2A	3.85346912648922
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	65/2910	144/9376	1.45437189767087	ID4/WNT4/LEFTY2/MEIS1/WNT5A/PIK3R1/STAT3/AKT3/MAPK14/TBX3/WNT5B/IGF1R/FGF2/PCGF5/IL6ST/JAK1/SMAD5/INHBB/PCGF2/BMPR2/ACVR1/SMAD2/KLF4/WNT9A/PIK3CA/SMAD9/MAPK1/BMI1/SKIL/WNT2/APC/AKT2/SMARCAD1/BMP4/SMAD1/SMAD4/RAF1/FZD2/IGF1/MAP2K1/MAP2K2/BMPR1A/KRAS/REST/WNT6/SMAD3/JAK2/DVL2/MYC/ACVR1B/PCGF1/FZD3/PIK3CD/INHBA/WNT3/ACVR2A/FZD10/FZD1/FZD4/FZD8/JAK3/MAPK12/MAPK11/PIK3R2/LIF	3.68603193609822
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	73/2910	166/9376	1.41690059205896	IRS2/ADRA2C/MYL9/IRS1/NPR1/ROCK2/ATP2B4/RGS2/ADCY1/AKT3/EDNRA/INSR/MEF2A/CALM2/BDKRB2/GNAI2/EDNRB/CREB3/ADCY3/CREB3L2/CREB3L1/TRPC6/ATP2A2/MYLK/PPP3CB/PPP3CC/GTF2I/NFATC4/MAPK1/GNA13/ATF2/MEF2D/ITPR2/AKT2/ATF6B/CREB1/SLC8A1/RAF1/MAP2K1/GNA11/MAP2K2/CREB5/ADORA1/PPP1R12A/KCNMB1/ROCK1/BAD/GNAQ/ADCY7/NPR2/AGTR1/ATP2B1/ATP1B3/KCNJ8/RHOA/ADCY9/PLN/SRF/MEF2C/PIK3R5/PLCB2/CACNA1C/ADRB3/PRKG1/PDE3A/ADCY6/PDE5A/GUCY1A2/PIK3CG/PDE3B/NFATC2/NFATC1/ADRA2A	3.63555754625717
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	36/2910	70/9376	1.65702503681885	FYN/SGCB/HLA-B/HLA-A/HLA-C/ACTG1/HLA-E/DTNA/HLA-F/HLA-DPB1/SGCE/EIF4G3/ABL1/HLA-DQA2/HLA-DRA/HLA-DPA1/HLA-DMB/SNTB2/HLA-DMA/HLA-DQA1/CXADR/CD86/BID/SSPN/ITGB2/ABL2/HLA-DQB1/CD40/HLA-DOA/HLA-DRB1/SNTA1/CAV1/RAC2/ICAM1/ITGAL/SNTB1	3.70138020232997
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	39/2910	78/9376	1.61099656357388	C3/CFL2/C1S/SERPING1/C1R/C2/MAPK14/CALM2/GNAI2/JUN/MYD88/C1QB/RELA/C1QA/MAPK1/CASP1/NFKB1/MAPK10/MAPK8/C1QC/LY96/IRAK1/ITGB2/PYCARD/TLR4/IRAK4/ITGB1/CFL1/TRAF6/RHOA/TICAM1/CD14/NOD1/ITGAM/IRF8/IL10/MAPK12/MAPK11/C5	3.63500975454193
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	56/2910	122/9376	1.47894766492029	FYN/PIK3R1/AKT3/MAPK14/JUN/PAK3/PTPN11/NCK1/PPP2R3C/RELA/CDK4/PPP3CB/PPP3CC/PPP2R5E/PIK3CA/MAPK1/PDPK1/PPP2CB/IKBKG/NFKB1/MAPK10/AKT2/PPP2CA/MALT1/PPP2R5B/RAF1/MAP2K1/IKBKB/MAP2K2/MAPK8/MAP3K7/KRAS/PPP2R2D/SOS2/CD4/MAP2K7/LCP2/NCK2/PTPRC/PAK2/SOS1/PPP2R3A/CHUK/RHOA/VAV1/NFKBIE/PIK3CD/PLCG1/IL10/MAPK12/MAPK11/LAT/CD247/NFATC2/PIK3R2/NFATC1	3.57204984546028
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	36/2910	71/9376	1.63368665601859	TJP1/LYN/JAM2/MAPK14/ATP6V1D/EGFR/JUN/PTPN11/ATP6V0D1/ATP6V0A1/RELA/ADAM10/SRC/IKBKG/ATP6V0E1/ATP6V1H/NFKB1/MAPK10/CSK/ATP6AP1/IKBKB/ATP6V1C1/MAPK8/ATP6V1G1/TCIRG1/ATP6V0B/CHUK/MAP2K4/NOD1/PLCG1/HBEGF/ATP6V1E2/MAPK12/MAPK11/PLCG2/ATP6V1G2	3.59550444639144
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	43/2910	89/9376	1.55669330862195	PDGFRA/PDGFRB/TUBA1A/GJA1/HTR2B/LPAR1/TJP1/PDGFD/ADCY1/MAPK7/PRKACB/GNAI2/EGFR/ADCY3/TUBA3E/MAP3K2/TUBB2A/PRKCA/CSNK1D/SRC/MAPK1/PRKACA/PDGFC/ITPR2/RAF1/MAP2K1/GNA11/MAP2K2/KRAS/SOS2/GNAQ/ADCY7/SOS1/MAP2K5/ADCY9/PDGFA/PLCB2/TUBB2B/TUBA3D/PRKG1/ADCY6/GUCY1A2/TUBA4A	3.53987204762123
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	18/2910	29/9376	1.99985780305723	WTIP/LATS2/CSNK1E/DCHS1/MOB1A/YAP1/NF2/RASSF4/RASSF1/SAV1/TEAD2/FAT4/WWTR1/FRMD6/MOB1B/AJUBA/LATS1/RASSF2	3.61755714676493
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	68/2910	156/9376	1.40445854260287	CD81/PIK3R1/STAT3/CFLAR/TNFRSF1A/AKT3/STAT1/IFNAR1/EGFR/JAK1/TRADD/FAS/MX2/FADD/RELA/CDK4/RB1/MX1/RNASEL/PIK3CA/MAPK1/STAT2/OAS2/PPP2CB/IKBKG/EIF2AK2/NFKB1/AKT2/OAS1/YWHAQ/PPP2CA/RAF1/MAP2K1/IKBKB/MAP2K2/NR1H3/KRAS/PPARA/BID/PIAS1/ARAF/PPP2R2D/BAD/SOS2/TRAF3/SCARB1/MAVS/IFIT1/LDLR/CLDN10/MYC/SOCS3/RIPK1/CXCL10/SOS1/CLDN23/TRAF6/CHUK/TICAM1/CDKN1A/PIK3CD/IRF9/RSAD2/IKBKE/CLDN12/TYK2/PIK3R2/CLDN15	3.41731595167214
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	33/2910	65/9376	1.6357811260904	KCNK3/ADCY1/PDE8B/PRKACB/CREB3/ADCY3/CREB3L2/CREB3L1/PBX1/PDE8A/PRKACA/ATF2/ITPR2/ATF6B/CREB1/GNA11/CREB5/GNAQ/ADCY7/SCARB1/NCEH1/STAR/LDLR/AGTR1/CACNA1G/SP1/ADCY9/AGT/POMC/PLCB2/CACNA1C/CACNA1H/ADCY6	3.45048726438288
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	35/2910	70/9376	1.61099656357388	RAP1B/VEGFA/EGLN2/PIK3R1/AKT3/JUN/PAK3/PTPN11/CREBBP/RAP1A/ETS1/HIF1A/PIK3CA/TFE3/MAPK1/CRK/AKT2/EGLN1/CUL2/PRCC/RAF1/MAP2K1/MAP2K2/KRAS/ARAF/BAD/SOS2/TGFB2/PAK2/SOS1/CDKN1A/PIK3CD/TGFB3/ARNT2/PIK3R2	3.44207672062814
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	36/2910	73/9376	1.58892811749753	MAP1B/MDFIC/MAP1A/BICD1/SERINC3/AFF4/CDK9/MX2/CREBBP/SAMHD1/FEZ1/PDCD6IP/NELFE/MX1/HGS/RANBP2/CHMP4A/ELL2/VPS4B/CHMP4B/BICD2/VPS4A/MAP1S/PIN1/CHMP6/NELFB/CCNT2/CD4/APOBEC3C/CPSF7/ELL/CXCR4/MLLT3/APOBEC3G/KAT2B/BST2	3.38864826054454
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	13/2910	19/9376	2.20452161331163	IDS/HEXA/NAGLU/GNS/SGSH/HYAL2/GLB1/GUSB/GALNS/HGSNAT/HPSE/IDUA/ARSB	3.52563513445221
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	61/2910	139/9376	1.4139682068778	GREB1/ESR1/PIK3R1/PGR/ADCY1/AKT3/CTSD/PRKACB/CALM2/GNAI2/EGFR/JUN/CREB3/ADCY3/CREB3L2/CREB3L1/MMP2/BCL2/SHC1/SRC/EBAG9/PIK3CA/MAPK1/SHC2/RARA/FKBP5/PRKACA/ATF2/ITPR2/AKT2/ATF6B/CREB1/RAF1/GNAO1/MAP2K1/MAP2K2/CREB5/KRAS/NCOA1/SOS2/HSP90B1/GNAQ/ADCY7/KRT34/GABBR1/KRT10/SOS1/HSPA1A/MMP9/SP1/ADCY9/PIK3CD/POMC/PLCB2/HBEGF/KCNJ5/ADCY6/HSPA1B/HSPA6/SHC3/PIK3R2	3.2985509683565
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	27/2910	51/9376	1.70576106731352	ACTG1/TJP1/ATP6V1D/PRKACB/ADCY3/ATP6V0D1/ATP6V0A1/PRKCA/ARF1/SEC61A1/ATP6V0E1/PRKACA/ATP6V1H/SEC61B/ATP6AP1/ATP6V1C1/ATP6V1G1/TCIRG1/ATP6V0B/SLC12A2/ADCY9/PLCG1/ATP6V1E2/SEC61A2/PLCG2/ATP6V1G2/SEC61G	3.39025720477233
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	11/2910	15/9376	2.36279495990836	ST3GAL5/ST6GALNAC6/HEXA/ST6GALNAC5/GLB1/ST6GALNAC4/SLC33A1/B3GALT4/ST3GAL2/ST3GAL1/ST6GALNAC3	3.54347447065836
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	30/2910	59/9376	1.63830159007514	GADD45G/PIK3R1/AKT3/EGFR/ILK/POLK/TCF7L2/PIK3CA/MAPK1/PDPK1/APC/AKT2/RAF1/MAP2K1/MAP2K2/KRAS/ARAF/BAD/SOS2/PTEN/MYC/SOS1/ELK1/FOXO3/DDB2/GADD45B/CDKN1A/PIK3CD/GADD45A/PIK3R2	3.29934831600832
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	47/2910	103/9376	1.47022987355286	LAMA4/PIK3R1/IL1R1/ADCY1/LAMB2/PRKACB/LAMC1/VCL/COL4A4/HSPB1/RELA/PRKCA/SERPINB6/PIK3CA/RAB7A/RAB5C/RAB5A/PRKACA/NFKB1/LAMB1/PTK2/GNA11/CD1D/RAB5B/ITGB2/LAMC3/GNAQ/TLR4/LAMA3/IL1R2/TGFB2/COL4A6/COL4A3/GNA15/COL4A5/SERPINB10/CD14/PIK3CD/TLR2/ITGAM/IL10/PLCB2/TGFB3/LAMB3/GNA14/PIK3R2/GNAL	3.21908897947006
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	67/2910	157/9376	1.37499069757261	WNT4/SERPINE1/ACTG1/WNT5A/TGFBR2/WNT5B/WTIP/FBXW11/TGFBR1/NKD2/BMPR2/SNAI2/LATS2/CSNK1E/BIRC2/SMAD2/CSNK1D/TCF7L2/WNT9A/MOB1A/PPP2CB/YAP1/WNT2/APC/YWHAQ/NF2/PPP2CA/BMP4/SMAD1/SMAD4/FZD2/BMPR1A/CCND2/RASSF1/SAV1/PPP2R2D/PRKCI/WNT6/SMAD3/ITGB2/TEAD2/WWTR1/DVL2/TGFB2/GLI2/GDF7/MYC/TP53BP2/FRMD6/BIRC3/MOB1B/PARD6G/FZD3/AJUBA/WNT3/LATS1/DLG4/FZD10/FZD1/BMP2/DLG3/CRB2/FZD4/SMAD7/TGFB3/FZD8/PARD6A	3.17864989030242
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	68/2910	160/9376	1.3693470790378	SDC2/CD99/ITGB8/HLA-B/VCAN/HLA-A/HLA-C/HLA-E/VCAM1/SDC3/HLA-F/JAM2/HLA-DPB1/ITGAV/PTPRM/NLGN4X/HLA-DQA2/HLA-DRA/GLG1/HLA-DPA1/HLA-DMB/HLA-DMA/CD58/SELPLG/CDH2/HLA-DQA1/NLGN2/NRXN2/ICAM2/CXADR/NRXN1/CD99L2/CD86/NEO1/PTPRD/ITGB2/ALCAM/NEGR1/CD4/HLA-DQB1/CD40/NLGN1/HLA-DOA/HLA-DRB1/CD226/CLDN10/SLITRK4/CNTN1/PTPRC/CDH3/ITGB1/CLDN23/NCAM1/NCAM2/ITGAM/CADM1/SPN/ITGA4/ICAM1/ITGAL/SIGLEC1/CD2/CLDN12/CD22/NFASC/CNTNAP1/NTNG2/CLDN15	3.16109617757745
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	41/2910	88/9376	1.50115588878475	F3/C3/PLAT/C1S/CFI/SERPING1/CLU/CFH/SERPINE1/F2R/CD59/PROS1/C1R/C2/PLAU/BDKRB2/A2M/CFD/VTN/PLAUR/C1QB/MASP1/C1QA/BDKRB1/SERPINB2/C1QC/C3AR1/F10/ITGB2/SERPINA1/VSIG4/CR1/ITGAM/F2RL3/ITGAX/F12/FGG/C5AR1/C5/F8/SERPINF2	3.16859952760544
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	74/2910	178/9376	1.33948028881424	MCC/WNT4/TLE2/WNT5A/ROR2/ROCK2/DKK1/WNT5B/PRKACB/FBXW11/JUN/NKD2/CREBBP/PRICKLE2/RSPO3/DAAM1/CBY1/CSNK1E/CTBP2/PPP3CB/PRKCA/PPP3CC/LZTS2/TBL1X/TCF7L2/NFATC4/WNT9A/BAMBI/CSNK2A1/WNT2/APC/PRKACA/MAPK10/SMAD4/FZD2/MAPK8/CCND2/MAP3K7/MMP7/CHD8/PRICKLE1/RYK/CAMK2D/WNT6/TLE4/SMAD3/TLE6/PSEN1/DVL2/SERPINF1/CSNK1A1/MYC/APCDD1/FZD3/LRP6/RHOA/FOSL1/RSPO1/RAC2/WNT3/FZD10/PLCB2/SIRT1/INVS/FZD1/FZD4/FZD8/ROR1/PORCN/VANGL2/NFATC2/CELSR1/FRAT1/NFATC1	3.06755348762438
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	93/2910	233/9376	1.2860315915225	SDC2/FBN1/LMOD1/ZYX/ITGB5/PDLIM4/SGCB/ITGB8/PDLIM2/VCAN/FHL1/PDLIM1/MYL9/NID2/DCN/VIM/ACTG1/THBS1/SDC3/DTNA/FBLN2/TMEM43/NID1/SPTAN1/SGCE/TPM2/ITGAV/SYNPO2/COL6A3/FBLN1/SPTBN1/SYNE1/VCL/COL4A4/DAAM1/THBS3/SNTB2/TLN2/SUN2/TLN1/TPM4/COL5A2/CAPZA2/TMOD3/THBS2/EMD/PLEC/PDLIM7/CSRP1/AGRN/CAPZB/FHL3/ITGB3/TMOD1/ITGA1/DIAPH2/MYL5/SSPN/ITGA3/TMOD2/COL5A1/TNNC2/MYH11/MYOM2/COL5A3/MYH9/FMNL1/SNTA1/ITGB1/COL4A6/AMPD2/ATP1B3/ITGA2/AMPD3/BGN/COL4A3/SUN1/LMNA/COL4A5/TNNT3/ACTN2/ITGA4/FMNL3/ENO2/COL24A1/FMNL2/SNTB1/ANK2/CAPN3/ELN/COL6A2/CKM/COMP	2.96593675354392
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	43/2910	95/9376	1.45837583649846	CTSK/IL15/VEGFA/CXCL12/HLA-DPB1/ATP6V1D/HLA-DQA2/JUN/HLA-DRA/HLA-DPA1/ATP6V0D1/HLA-DMB/ATP6V0A1/HLA-DMA/HLA-DQA1/ATP6V0E1/TNFSF13B/ATP6V1H/CSF1/ATP6AP1/ATP6V1C1/CD86/ATP6V1G1/IL18/TCIRG1/ITGB2/ACP5/IL11/HLA-DQB1/TLR4/HLA-DOA/TGFB2/HLA-DRB1/MMP1/ATP6V0B/TLR2/ICAM1/MMP3/ITGAL/ATP6V1E2/TGFB3/ATP6V1G2/TEK	3.01231520799623
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	44/2910	98/9376	1.44660915912757	SPHK1/CFL2/GSN/MARCKS/PIP5K1C/MARCKSL1/PIK3R1/LYN/AKT3/PLD1/BIN1/ASAP2/WASF2/FCGR3A/PRKCA/PIK3CA/MAPK1/CRK/LIMK1/WASF1/AKT2/RAF1/MAP2K1/RPS6KB1/GAB2/SYK/AMPH/FCGR2A/PTPRC/FCGR1A/CFL1/DOCK1/SPHK2/VAV1/WASF3/PIK3CD/PLCG1/INPPL1/RAC2/HCK/PIP5K1B/LAT/PLCG2/PIK3R2	2.98145158751725
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	44/2910	98/9376	1.44660915912757	NPR1/ATP2B4/KCNK3/ADCY1/CAMK1/PRKACB/CALM2/CREB3/ADCY3/CREB3L2/CREB3L1/PRKCA/PRKACA/ATF2/ITPR2/ATF6B/CREB1/GNA11/CREB5/CAMK1D/CAMK2D/GNAQ/ADCY7/SCARB1/STAR/LDLR/DAGLB/AGTR1/ATP2B1/CACNA1G/PRKD1/ATP1B3/PRKD2/ADCY9/AGT/POMC/PLCB2/CACNA1C/KCNJ5/DAGLA/NR4A2/LIPE/CACNA1H/ADCY6	2.98145158751725
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	34/2910	72/9376	1.52149675448645	MAPK14/TRADD/AZI2/FADD/RELA/TANK/ZNFX1/CYLD/IKBKG/NFKB1/ADAR/MAPK10/SIKE1/TRIM25/DHX58/IKBKB/MAPK8/OTUD5/MAP3K7/PIN1/TRAF3/MAVS/RIPK1/CXCL10/TRAF6/CHUK/IFIH1/RNF125/CASP10/NLRX1/IKBKE/MAPK12/MAPK11/TBKBP1	2.97986980744904
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	26/2910	52/9376	1.61099656357388	APOE/APOA1/NPC2/LIPA/OSBPL5/ABCA1/SOAT1/TSPO/LRP1/LPL/LRPAP1/CYP27A1/STARD3NL/STARD3/APOC1/VAPA/SOAT2/SCARB1/NCEH1/STAR/LDLR/CD36/APOC3/APOC2/CIDEB/LCAT	2.96383204687321
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	41/2910	91/9376	1.45166723311053	CD81/PIK3R1/LYN/AKT3/JUN/RELA/PPP3CB/PPP3CC/PIK3CA/MAPK1/IKBKG/NFKB1/AKT2/MALT1/LILRB4/RAF1/MAP2K1/IKBKB/MAP2K2/KRAS/SOS2/CD72/SYK/SOS1/PIK3AP1/IFITM1/CHUK/VAV1/NFKBIE/LILRB2/BTK/PIK3CD/INPPL1/LILRB1/RAC2/LILRB3/CD22/PLCG2/NFATC2/PIK3R2/NFATC1	2.90444134147294
Human Diseases	Cancer: specific types	hsa05218	Melanoma	34/2910	73/9376	1.50065433319211	PDGFRA/PDGFRB/GADD45G/PIK3R1/PDGFD/AKT3/MITF/IGF1R/FGF2/EGFR/FGF7/POLK/CDK4/RB1/PIK3CA/MAPK1/PDGFC/AKT2/RAF1/IGF1/MAP2K1/MAP2K2/KRAS/ARAF/BAD/FGF10/PTEN/DDB2/GADD45B/CDKN1A/PIK3CD/PDGFA/GADD45A/PIK3R2	2.88072751987877
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	18/2910	33/9376	1.75745079662605	STX4/VAMP5/VAMP2/VAMP3/STX7/SNAP23/STX2/STX5/STX18/USE1/GOSR1/STX8/GOSR2/VAMP4/STX16/VTI1A/STX11/STX1A	2.92403458279472
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	56/2910	133/9376	1.35662868511485	GNG4/MAOB/AKT3/MAPK14/PRKACB/CALM2/GNG11/GNAI2/MAOA/KIF5B/CREB3/CREB3L2/CREB3L1/GNB5/PPP2R3C/GNB2/PPP3CB/PRKCA/PPP3CC/PPP2R5E/CLOCK/PPP2CB/PRKACA/GNB1/MAPK10/ATF2/ITPR2/AKT2/ATF6B/PPP2CA/CREB1/PPP2R5B/GNAO1/MAPK8/CREB5/GRIA3/PPP2R2D/CAMK2D/GSK3A/GNG2/GNB4/GNAQ/KIF5A/GRIA4/PPP2R3A/ARRB2/PLCB2/CACNA1C/KCNJ5/MAPK12/MAPK11/KIF5C/GNGT2/GNB3/CACNA1A/GNAL	2.77875270746141
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	20/2910	38/9376	1.69578585639356	NNMT/ENPP1/AOX1/NT5E/BST1/SIRT2/NAMPT/NT5C/NNT/NADK/CD38/NT5C2/NMNAT1/SIRT6/NUDT12/NADSYN1/SIRT3/NMNAT2/SARM1/SIRT1	2.88306704844816
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	44/2910	101/9376	1.40364057024259	WNT4/WNT5A/ADCY1/WNT5B/MITF/PRKACB/CALM2/GNAI2/EDNRB/CREB3/ADCY3/CREB3L2/CREB3L1/CREBBP/ASIP/PRKCA/TCF7L2/WNT9A/MAPK1/WNT2/PRKACA/CREB1/RAF1/FZD2/GNAO1/MAP2K1/MAP2K2/KRAS/CAMK2D/WNT6/GNAQ/ADCY7/DVL2/FZD3/ADCY9/WNT3/POMC/FZD10/PLCB2/FZD1/FZD4/FZD8/ADCY6/KITLG	2.73597938881982
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	41/2910	93/9376	1.42044858293611	ADCY1/MAPK14/MAPK7/PRKACB/CALM2/EGFR/MAP3K4/JUN/MMP14/PLD1/ADCY3/MMP2/MAP3K2/PRKCA/SRC/MAPK1/PRKACA/MAP3K3/MAPK10/ITPR2/RAF1/MAP2K1/GNA11/MAP2K2/MAPK8/KRAS/CAMK2D/SOS2/GNAQ/ADCY7/MAP2K7/SOS1/ELK1/MAP2K4/ADCY9/PLCB2/HBEGF/CACNA1C/MAPK12/MAPK11/ADCY6	2.73353396620004
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	21/2910	41/9376	1.65028916268544	VEGFA/THBS1/EGFR/MMP2/DAPK3/CDK4/RB1/SRC/MAPK1/RAF1/MAP2K1/MAP2K2/RASSF1/KRAS/ARAF/MYC/MMP1/MMP9/CDKN1A/HBEGF/DAPK2	2.79933946047548
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	28/2910	59/9376	1.52908148407013	IRS2/IRS1/PIK3R1/NPR1/ABHD5/ADCY1/AKT3/INSR/PRKACB/GNAI2/ADCY3/PNPLA2/MGLL/PIK3CA/PRKACA/AKT2/ADORA1/ADCY7/PTGS1/ADCY9/PIK3CD/ADRB3/PRKG1/LIPE/FABP4/ADCY6/PDE3B/PIK3R2	2.73479516679956
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	55/2910	133/9376	1.33240317288066	IFNGR2/FYN/HLA-B/HLA-A/HLA-C/HLA-E/PIK3R1/IFNAR1/FAS/IFNGR1/PTPN11/MICA/FCGR3A/PPP3CB/PRKCA/PPP3CC/SHC1/PIK3CA/MAPK1/SHC2/ICAM2/RAF1/MAP2K1/MAP2K2/KRAS/BID/ARAF/SOS2/ITGB2/LCP2/CD48/SYK/SOS1/HCST/SH3BP2/VAV1/PIK3CD/PLCG1/RAC2/LAT2/TYROBP/ICAM1/MICB/ITGAL/LAT/PLCG2/FCER1G/CD247/SHC3/KLRC2/KLRC1/NFATC2/PIK3R2/KLRD1/NFATC1	2.58999417366953
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	61/2910	150/9376	1.31027720504009	WNT4/GADD45G/WNT5A/PIK3R1/AKT3/TGFBR2/WNT5B/FGF2/EGFR/FGF7/TGFBR1/BCL2/POLK/CDKN2B/RB1/SHC1/SMAD2/TCF7L2/WNT9A/PIK3CA/MAPK1/SHC2/WNT2/APC/AKT2/SMAD4/RAF1/FZD2/MAP2K1/MAP2K2/CDKN1B/KRAS/ARAF/WNT6/RXRB/SOS2/SMAD3/RPS6KB1/FGF10/DVL2/CSNK1A1/TGFB2/MYC/SOS1/DDB2/FZD3/LRP6/GADD45B/CDKN1A/PIK3CD/WNT3/MTOR/FZD10/GADD45A/FZD1/FZD4/TGFB3/FZD8/SHC3/PIK3R2/FRAT1	2.56982208808558
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	29/2910	63/9376	1.48313969344897	WNT4/GADD45G/WNT5A/WNT5B/POLK/TCF7L2/WNT9A/WNT2/APC/BMP4/FZD2/WNT6/PTCH1/DVL2/GLI2/DDB2/FZD3/GADD45B/CDKN1A/SUFU/SMO/WNT3/FZD10/GADD45A/FZD1/BMP2/FZD4/FZD8/KIF7	2.58114543261573
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	40/2910	93/9376	1.38580349554743	RAP1B/FYN/MYL9/ACTG1/ROCK2/TJP1/INSR/TGFBR2/IGF1R/PTPRM/EGFR/TGFBR1/VCL/CREBBP/SORBS1/SNAI2/RAP1A/WASF2/WASL/CCM2/SRC/TCF7L2/MAPK1/PTPN1/CSNK2A1/WASF1/SMAD4/KRIT1/MYL5/MAP3K7/ROCK1/SMAD3/SMURF2/BAIAP2/RHOA/WASF3/RAC2/RADIL/PTPRJ/MYL12B	2.50828996019674
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	12/2910	21/9376	1.84113892979872	CHST3/CHST7/CSGALNACT2/CHST15/CHPF2/B3GALT6/CHSY1/DSE/CHST11/UST/CHST14/CHSY3	2.58862873399208
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	79/2910	205/9376	1.24164613192524	C3/GSN/HLA-B/HLA-A/HLA-C/HLA-E/PIK3R1/STAT3/HLA-F/LYN/MAPKAPK2/PRKACB/IL6ST/JAK1/JUN/TRADD/HDAC7/CREB3/CREB3L2/CREB3L1/ATP6V0D1/CREBBP/SP100/RELA/CHD4/CDK4/CDKN2B/RBPJ/RB1/SRC/GTF2A1/PIK3CA/LTBR/MAPK1/IKBKG/GTF2E2/EIF2AK2/UBE3A/STAT5B/PRKACA/NFKB1/ATF2/ATF6B/RBL2/YWHAQ/CREB1/UBR4/CREB5/CCND2/NFKB2/CDKN1B/SNW1/KRAS/MAD1L1/BAD/GTF2H1/HDAC3/TRAF3/RASA2/VAC14/SYK/HDAC4/TRAF5/HDAC11/USP7/RHOA/CDKN1A/PIK3CD/IRF9/GTF2H2C/GTF2E1/STAT5A/SRF/KAT2B/TBP/JAK3/HDAC9/PIK3R2/TRAF1	2.34672777794205
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	21/2910	44/9376	1.5377694470478	MGAT2/HEXA/MGAT4B/ALG2/MAN1A1/B4GALT3/B4GALT2/MGAT1/MGAT4C/ALG14/RPN1/ALG1/FUT8/ALG13/MAN1C1/DAD1/KRTCAP2/ST3GAL3/ALG11/MAN2A2/OSTC	2.39855333611759
Human Diseases	Immune disease	hsa05330	Allograft rejection	19/2910	39/9376	1.56968895937968	HLA-B/HLA-A/HLA-C/HLA-E/HLA-F/HLA-DPB1/HLA-DQA2/FAS/HLA-DRA/HLA-DPA1/HLA-DMB/HLA-DMA/HLA-DQA1/CD86/HLA-DQB1/CD40/HLA-DOA/HLA-DRB1/IL10	2.3915568529713
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	47/2910	115/9376	1.31681458239952	GNG4/FYN/PIK3R1/ADCY1/AKT3/PRKACB/GNG11/GNAI2/CREB3/ADCY3/CREB3L2/CREB3L1/GNB5/BCL2/GNB2/PRKCA/PIK3CA/MAPK1/PRKACA/GNB1/ITPR2/AKT2/CREB1/GNAO1/MAP2K1/GNA11/CREB5/KRAS/CAMK2D/GNG2/GNB4/GNAQ/JAK2/ADCY7/ADCY9/PIK3CD/PIK3R5/PLCB2/CACNA1C/GNGT2/KCNJ12/ADCY6/PIK3CG/GNB3/CACNA1A/PIK3R2/KCNJ2	2.29318675016735
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	10/2910	17/9376	1.8952900747928	PAPSS2/MTR/TXNRD2/SEPHS1/PAPSS1/TXNRD1/INMT/TXNRD3/SCLY/SEPSECS	2.4784935299483
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	35/2910	82/9376	1.37524096890453	CTSB/HLA-B/CTSS/HLA-A/HLA-C/B2M/HLA-E/HLA-F/HLA-DPB1/HLA-DQA2/HLA-DRA/TAP1/HLA-DPA1/HLA-DMB/TAPBP/TAPBPL/HLA-DMA/HLA-DQA1/CD74/CREB1/CD4/HLA-DQB1/IFI30/HLA-DOA/HLA-DRB1/HSPA1A/CIITA/RFX5/LGMN/RFXAP/HSPA1B/HSPA6/KLRC2/KLRC1/KLRD1	2.28944451788903
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	25/2910	55/9376	1.46454233052171	SPHK1/SPTLC2/CERS6/PSAP/HEXA/CERK/ARSA/DEGS1/CERS4/ACER3/CERS2/SMPD1/GLB1/ASAH1/SGPL1/SPTLC1/SAMD8/UGCG/SGMS1/SGMS2/KDSR/B4GALT5/GALC/SPHK2/GBA2	2.31787316602831
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	45/2910	110/9376	1.31808809746954	IFNGR2/SERPINE1/VEGFA/TIMP1/EGLN2/PIK3R1/STAT3/AKT3/INSR/IGF1R/EGFR/IFNGR1/CREBBP/BCL2/RELA/PRKCA/HIF1A/PIK3CA/LTBR/MAPK1/IL6R/NFKB1/AKT2/EGLN1/CUL2/IGF1/MAP2K1/MAP2K2/CDKN1B/CAMK2D/RPS6KB1/PFKM/PFKFB3/TLR4/CDKN1A/PIK3CD/PLCG1/MTOR/CYBB/ENO2/HK3/PLCG2/TEK/ANGPT2/PIK3R2	2.25118867736522
Human Diseases	Substance dependence	hsa05032	Morphine addiction	38/2910	91/9376	1.3454476794683	GNG4/ADCY1/GRK5/PDE8B/PRKACB/GNG11/GNAI2/ADCY3/GNB5/PDE4B/GNB2/PRKCA/GABRA2/PDE8A/PRKACA/GNB1/GNAO1/ADORA1/GRK4/PDE4A/GNG2/GNB4/ADCY7/GABBR1/GRK6/ARRB2/PDE10A/ADCY9/PDE7A/KCNJ5/GABRE/GNGT2/PDE3A/ADCY6/PDE3B/GNB3/CACNA1A/GABRB3	2.22139763084847
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	32/2910	75/9376	1.37471706758305	SERPINE1/CD82/CHEK2/TP53I3/THBS1/GADD45G/IGFBP3/AIFM2/SESN3/FAS/BCL2/BCL2L1/CDK4/ZMAT3/IGF1/CCND2/ZNF385A/BID/RCHY1/SESN1/ATM/PTEN/CCNG2/GORAB/RRM2B/ATR/DDB2/GADD45B/CDKN1A/TSC2/GADD45A/PPM1D	2.18566484418831
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	25/2910	56/9376	1.43838978890525	MGAT2/MGAT4B/ALG2/MAN1A1/B4GALT3/ALG5/B4GALT2/MGAT1/DPM2/MGAT4C/DPM3/ALG14/RPN1/ALG1/ST6GAL2/FUT8/MGAT3/ALG13/MAN1C1/DAD1/DOLK/KRTCAP2/ALG11/MAN2A2/OSTC	2.20729698344365
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	22/2910	48/9376	1.47674684994273	ALDH9A1/AOX1/ACAT1/ACAA1/ACAA2/HMGCL/IVD/HIBCH/BCAT1/HADHB/ACAD8/ACADM/HADHA/ACSF3/IL4I1/OXCT1/ALDH3A2/ABAT/ALDH6A1/AACS/MCCC1/OXCT2	2.22140868099768
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	10/2910	18/9376	1.78999618174876	HEXA/FUCA2/GLB1/AGA/MAN2C1/MAN2B2/MANBA/ENGASE/MAN2B1/GBA2	2.25052585632615
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	81/2910	217/9376	1.20267946220723	GSTT1/VEGFA/ESR1/PIK3R1/PGR/STAT3/ADCY1/AKT3/GSTM3/CYP1B1/MGST1/PRKACB/FGF2/GNAI2/EGFR/KPNA3/FGF7/JUN/RPS6KA3/CREB3/ADCY3/CREB3L2/CREB3L1/BCL2/RELA/RB1/PRKCA/KLF4/SRC/PIK3CA/DLL1/MAPK1/XIAP/AIP/STAT5B/PRKACA/NFKB1/ATF2/AR/AKT2/ATF6B/CREB1/RAF1/MAP2K1/MAP2K2/CREB5/KRAS/PPARA/KPNA6/KPNA1/NOTCH2/BAD/RXRB/SOS2/RPS6KB1/HSP90B1/FGF10/JAK2/KPNA5/MIR29A/ADCY7/GSTM5/MYC/SOS1/VDR/GSTO1/PAQR8/ARRB2/ADCY9/AHR/PIK3CD/STAT5A/RPS6KA2/MTOR/CACNA1C/IKBKE/ADRB3/ADCY6/JAG1/CACNA1A/PIK3R2	2.02642186687205
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	12/2910	23/9376	1.68103989242492	B4GALT3/B4GALT2/POMGNT1/CHST10/POMGNT2/POMT2/FKTN/FKRP/B3GALNT2/ST3GAL3/B3GAT2/FUT4	2.19369014985671
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	22/2910	49/9376	1.44660915912757	GALNT15/RFNG/LFNG/PLOD3/B4GALT3/GALNT7/GALNT11/C1GALT1C1/B4GALT2/EOGT/POGLUT1/ST6GAL2/POFUT2/GALNT13/FUT11/POMT2/OGT/GALNT10/ST3GAL3/MFNG/GXYLT2/FUT10	2.10265954789607
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	40/2910	100/9376	1.28879725085911	CD44/CD59/IL1R1/HLA-DPB1/HLA-DQA2/HLA-DRA/HLA-DPA1/ANPEP/HLA-DMB/IL4R/HLA-DMA/HLA-DQA1/IL6R/ITGB3/CSF1/ITGA1/CD37/CD38/CD1D/ITGA3/FLT3LG/IL11/CD4/HLA-DQB1/IL1R2/HLA-DOA/HLA-DRB1/FCGR1A/ITGA2/CR1/EPOR/CD36/IL2RA/CD14/ITGAM/THPO/ITGA4/CD2/CD22/KITLG	1.94772198910653
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	22/2910	50/9376	1.41767697594502	SDC2/CD81/THBS1/VCAM1/GYPC/MYD88/THBS3/LRP1/THBS2/IL18/ITGB2/TLR4/CD40/TGFB2/CR1/CD36/TLR2/ICAM1/IL10/ITGAL/TGFB3/COMP	1.98651621802459
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	16/2910	34/9376	1.51623205983424	POLR3GL/CRCP/POLR1E/POLR3D/POLR2B/POLR2C/POLR2A/POLR3H/POLR2M/POLR3C/POLR3E/POLR2J3/POLR3F/POLR1A/POLR1B/POLR2L	2.02292034334112
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	36/2910	89/9376	1.30327811884629	GLUL/GNG4/ADCY1/GABARAP/GABARAPL1/PRKACB/GNG11/GNAI2/ADCY3/GNB5/GABARAPL2/GNB2/PRKCA/GABRA2/PLCL1/SRC/SLC38A2/TRAK2/PRKACA/GNB1/GNAO1/GNG2/ABAT/GNB4/ADCY7/GABBR1/ADCY9/CACNA1C/GABRE/SLC6A12/GPHN/GNGT2/ADCY6/GNB3/CACNA1A/GABRB3	1.92846890546725
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	8/2910	14/9376	1.84113892979872	CHST2/CHST1/B4GALT3/B4GALT2/ST3GAL2/FUT8/ST3GAL1/ST3GAL3	2.11281618736237
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	23/2910	53/9376	1.39822343253582	ESR1/ATP2B4/PRKACB/CLTB/BDKRB2/AP2M1/PRKCA/CLTC/PRKACA/AP2B1/SLC8A1/GNAQ/AP2A2/DNM1/ATP2B1/VDR/ATP1B3/ADCY9/PLCB2/CLTCL1/AP2S1/KL/ADCY6	1.95029894908994
Cellular Processes	Cell motility	hsa04814	Motor proteins	72/2910	194/9376	1.19579126368371	TUBA1A/DYNLT3/MYL9/MYL6/ACTG1/TPM2/KIF1B/DYNC2LI1/DCTN2/KIF13A/KIF5B/KIF16B/DYNC1H1/DYNC1LI1/KLC1/ACTR1A/TUBA3E/HOOK3/DCTN6/ACTR10/DNALI1/MYO5A/TPM4/TUBB2A/DYNC2H1/MYO1C/MYO6/CAPZA2/MYO9B/KIFAP3/KIF3B/MYO1E/DYNC1I2/ACTR1B/DYNC1LI2/MYL6B/MYO9A/CAPZB/DNAL4/DCTN1/MYL5/KIF1C/TUBE1/KIF3A/DYNLRB1/MYO16/DNAL1/DCTN3/TNNC2/MYH11/MYH9/KIF5A/KIF13B/ACTA2/KIFC3/TUBG2/MYO1F/DYNLT1/KLC2/TNNT3/TUBB2B/MYO15B/TUBA3D/TUBD1/STARD9/KIF27/MYL12B/KIF5C/KIF7/DYNLRB2/TUBA4A/MYO1D	1.84858665165013
NA	NA	hsa03272	Virion - Hepatitis viruses	21/2910	48/9376	1.40962199312715	CD81/CD63/TGOLN2/EGFR/LAMP1/LAMP2/PDCD6IP/CHMP4A/VPS4B/IST1/CHMP4B/CHMP1B/VPS4A/CHMP1A/CHMP7/SCARB1/LDLR/CLDN10/CLDN23/CLDN12/CLDN15	1.90863946257754
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	15/2910	32/9376	1.51030927835052	TNFRSF1A/FADD/BCL2/BIRC2/BCL2L1/BECN1/XIAP/HTRA2/BOK/MAPK10/MAPK8/BID/BIRC6/BIRC3/BCL2L11	1.93979717045305
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	39/2910	99/9376	1.26927001978548	C3/C1S/CFI/CFH/C1R/C2/HLA-DPB1/HLA-DQA2/CFD/HLA-DRA/HLA-DPA1/HLA-DMB/C1QB/FCGR3A/HLA-DMA/MASP1/C1QA/SELPLG/HLA-DQA1/FPR3/C1QC/C3AR1/ITGB2/KRT34/HLA-DQB1/HLA-DOA/CAMP/HLA-DRB1/KRT10/FCGR2A/FCGR1A/PTAFR/ITGAM/FGG/ICAM1/IL10/ITGAL/C5AR1/C5	1.80682505323397
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	41/2910	105/9376	1.25811160202913	ITGB5/SGCB/ITGB8/ACTG1/DTNA/ADCY1/SGCE/TPM2/ITGAV/PRKACB/CACNB3/ADCY3/SNTB2/ATP2A2/CACNA2D1/TPM4/EMD/CACNB2/PRKACA/SLC8A1/ITGB3/IGF1/ITGA1/SSPN/ITGA3/ADCY7/TGFB2/SNTA1/ITGB1/ITGA2/LMNA/ADCY9/PLN/CACNB1/AGT/CACNA2D4/ITGA4/CACNA1C/TGFB3/SNTB1/ADCY6	1.78423957497845
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	14/2910	30/9376	1.50359679266896	PIGT/GPAA1/B3GALT4/PIGC/DPM2/PIGH/PIGX/PIGM/PIGV/PIGQ/PIGZ/PIGL/PGAP3/PGAP1	1.85329680509934
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	37/2910	94/9376	1.26823133728157	MAPK14/MAPK7/JUN/TRADD/FADD/IL17RC/RELA/MAPK1/IKBKG/TRAF3IP2/NFKB1/MAPK10/USP25/MAPK6/JUND/IKBKB/MAPK8/MAP3K7/HSP90B1/TRAF3/TAB2/MMP1/CXCL10/TRAF5/MMP9/TRAF6/CHUK/IL17RE/FOSL1/IL17RA/MMP3/IKBKE/CEBPB/TAB3/MAPK12/MAPK11/CCL7	1.75334323533061
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	38/2910	97/9376	1.26222411166614	GNG4/ADCY1/PRKACB/CALM2/GNG11/GNAI2/ADCY3/GNB5/GNB2/PRKCA/MAPK1/PRKACA/GNB1/CREB1/GNAO1/GRIA3/CAMK2D/PER1/GNG2/GNB4/GNAQ/ADCY7/PER2/GRIA4/NOS1AP/CACNA1G/RASD1/ADCY9/PER3/PLCB2/CACNA1C/KCNJ5/PRKG1/CACNA1H/GNGT2/ADCY6/GUCY1A2/GNB3	1.74149481258836
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	26/2910	63/9376	1.32971144929908	ALDH9A1/KMT2E/SETDB2/SETD7/KMT2A/ASH1L/ACAT1/PHYKPL/PLOD3/NSD1/KMT2B/EZH1/SETD2/DLST/HADHA/AASS/ALDH3A2/PRDM2/PRDM6/EHMT2/TMLHE/SETD1B/CAMKMT/SETMAR/SETD1A/KMT2D	1.7614640506231
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	19/2910	44/9376	1.39131521399563	HLA-B/HLA-A/HLA-C/HLA-E/HLA-F/HLA-DPB1/HLA-DQA2/FAS/HLA-DRA/HLA-DPA1/HLA-DMB/HLA-DMA/HLA-DQA1/CD86/PTPRN2/HLA-DQB1/HLA-DOA/HLA-DRB1/PTPRN	1.74533978669739
NA	NA	hsa04081	Hormone signaling	79/2910	219/9376	1.16227149335467	PRLR/GNG4/IRS2/ADRA2C/RAMP1/IRS1/RAMP3/ESR1/PIK3R1/NPR1/STAT3/PRL/VIPR2/ADCY1/ITGAV/INSR/IGF1R/HEPH/PRKACB/GNG11/GNAI2/NPR3/SMAD5/ADCY3/GNB5/GNB2/ACVR1/THRA/SRC/PIK3CA/SMAD9/HAMP/GNA13/OXT/STAT5B/PRKACA/GNB1/SMAD1/ITGB3/SMAD4/APPL1/IGF1/GNAO1/GNA11/BMPR1A/STK11/GNG2/PTHLH/GNB4/GNAQ/JAK2/ADCY7/NPR2/OXTR/SLC40A1/AGTR1/EPOR/CSH1/RHOA/GNA15/ADCY9/LEPR/PIK3CD/STAT5A/AVPR1A/AGT/POMC/THPO/PLCB2/ADRB3/PRKG1/CSH2/GNA14/GNGT2/ADCY6/GNB3/PIK3R2/SLC16A10/ADRA2A	1.63005390225709
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	30/2910	75/9376	1.28879725085911	MAP3K5/GSTT1/PIK3R1/AKT3/GSTM3/MGST1/REV3L/ERCC1/FAS/FADD/BCL2/BIRC2/BCL2L1/PIK3CA/MAPK1/XIAP/PDPK1/XPA/AKT2/BID/BAD/TOP2B/ATM/GSTM5/BIRC3/GSTO1/ATP7A/CDKN1A/PIK3CD/PIK3R2	1.68450826745725
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	20/2910	47/9376	1.37106090516926	IRS2/SOCS2/IRS1/PIK3R1/INSR/SOCS1/PIK3CA/MAPK1/MAPK10/IKBKB/SOCS4/MAPK8/SOCS3/CACNA1G/PIK3CD/MTOR/CACNA1C/HK3/CACNA1A/PIK3R2	1.71076700136726
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	40/2910	104/9376	1.23922812582606	LPGAT1/PLD1/CHPT1/PCYT1A/PISD/PLD3/GPCPD1/CDIPT/AGPAT1/LPIN1/PGS1/AGPAT3/ETNK1/PLA2G15/DGKH/MBOAT7/LPIN2/SAMD8/AGPAT2/GDPD5/MBOAT2/CRLS1/DGKE/LPCAT2/SGMS1/SGMS2/GNPAT/CHKB/AGPAT4/CEPT1/LPIN3/DGKA/PNPLA7/PLD4/ETNK2/CHKA/DGKQ/DGKD/GPAT2/LCAT	1.64572201445887
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	48/2910	128/9376	1.20824742268041	ENPP1/PAPSS2/NPR1/ADCY1/PDE8B/AK3/NTPCR/NT5E/ADCY3/PDE4B/NUDT9/PDE8A/NME7/GUK1/NT5C/GMPR2/PAPSS1/ENTPD4/NUDT16/HPRT1/ENTPD3/PDE6D/PDE4A/NME3/ADCY7/NME4/NT5C2/NPR2/AK1/AK9/AMPD2/RRM2B/PRPS1/AMPD3/ENTPD5/PDE10A/GMPR/ADCY9/PDE6B/LACC1/PDE7A/PDE3A/ADCY6/PDE5A/ENPP4/GUCY1A2/PDE3B/PDE9A	1.59138401734068
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	50/2910	134/9376	1.20223624147305	RAMP1/MYL9/RAMP3/CALD1/MYL6/NPR1/ROCK2/ADCY1/EDNRA/PRKACB/CALM2/ADCY3/PTGIR/MYLK/PRKCA/PPP1R14A/ARHGEF12/MAPK1/GNA13/PRKACA/MYL6B/ITPR2/RAF1/MAP2K1/GNA11/MAP2K2/PPP1R12A/ARAF/KCNMB1/ROCK1/MYH11/GNAQ/ADCY7/MYH9/NPR2/PPP1R12C/AGTR1/ACTA2/ARHGEF11/PPP1R12B/ADORA2B/RHOA/ADCY9/AVPR1A/AGT/PLCB2/CACNA1C/PRKG1/ADCY6/GUCY1A2	1.58176763485514
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	18/2910	42/9376	1.38085419734904	SAT1/MAP1LC3A/PRNP/FTH1/SAT2/SLC39A14/ACSL3/ATG7/ACSL1/PCBP1/SLC3A2/FTL/PCBP2/SLC40A1/MAP1LC3B/GCLC/CYBB/ACSL5	1.65944848800669
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	38/2910	99/9376	1.23672463466278	ITGB5/SGCB/ITGB8/ACTG1/DTNA/ACE/SGCE/TPM2/ITGAV/CACNB3/SNTB2/ATP2A2/CACNA2D1/TPM4/PRKAG1/EMD/CACNB2/PRKAA1/PRKAG2/SLC8A1/ITGB3/IGF1/ITGA1/SSPN/ITGA3/TGFB2/SNTA1/ITGB1/ITGA2/LMNA/CACNB1/AGT/CACNA2D4/ITGA4/CACNA1C/TGFB3/SNTB1/PRKAA2	1.58844271251257
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	23/2910	56/9376	1.32331860579283	C3/EEF1A1/MYD88/SAR1B/RELA/ARF1/CASP1/NFKB1/CLK4/NFKB2/IL18/ITGB2/PYCARD/TLR4/NAIP/HSPA1A/CR1/CD14/TLR5/TLR2/ITGAM/HSPA1B/HSPA6	1.62791242250391
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	19/2910	45/9376	1.36039709812906	HLA-B/HLA-A/HLA-C/HLA-E/HLA-F/HLA-DPB1/HLA-DQA2/FAS/HLA-DRA/HLA-DPA1/HLA-DMB/HLA-DMA/HLA-DQA1/CD86/HLA-DQB1/HLA-DOA/HLA-DRB1/KLRC1/KLRD1	1.62568998455315
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	16/2910	37/9376	1.39329432525309	GADD45G/NTRK1/POLK/TCF7L2/TFG/MAPK1/MAP2K1/MAP2K2/KRAS/RXRB/MYC/TPR/DDB2/GADD45B/CDKN1A/GADD45A	1.60798738396447
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	61/2910	168/9376	1.16989036164294	GLUL/IFNGR2/CAPN2/STAT3/CFLAR/TNFRSF1A/STAT1/IFNAR1/FTH1/JAK1/TRADD/FAS/IFNGR1/FADD/CHMP3/SMPD1/BCL2/BIRC2/SHARPIN/CYLD/CHMP4A/GLUD1/STAT2/XIAP/CASP1/EIF2AK2/VPS4B/STAT5B/MAPK10/CHMP4B/STAT6/CHMP1B/VPS4A/MAPK8/BID/CHMP1A/CHMP7/CAMK2D/CHMP6/JAK2/PYCARD/TLR4/TRPM7/FTL/CHMP5/MLKL/SQSTM1/SPATA2L/RIPK1/PYGB/BIRC3/TRAF5/TICAM1/IRF9/STAT5A/CYBB/JAK3/TYK2/PYGM/USP21/STAT4	1.49057903618939
Human Diseases	Immune disease	hsa05310	Asthma	14/2910	32/9376	1.40962199312715	HLA-DPB1/PRG2/HLA-DQA2/HLA-DRA/HLA-DPA1/HLA-DMB/HLA-DMA/HLA-DQA1/HLA-DQB1/CD40/HLA-DOA/HLA-DRB1/IL10/FCER1G	1.55706277924582
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	34/2910	89/9376	1.23087377891038	CD44/ITGB5/TNXB/ITGB8/THBS1/LAMA4/ITGAV/LAMB2/COL6A3/LAMC1/VTN/COL4A4/THBS3/THBS2/TNC/SPP1/AGRN/LAMB1/ITGB3/ITGA1/ITGA3/LAMC3/LAMA3/ITGB1/COL4A6/ITGA2/CD36/COL4A3/COL4A5/FREM1/ITGA4/LAMB3/COL6A2/COMP	1.46806800770897
Organismal Systems	Endocrine system	hsa04924	Renin secretion	27/2910	69/9376	1.26077991931869	CTSB/NPR1/ACE/EDNRA/PRKACB/CALM2/GNAI2/PPP3CB/PPP3CC/PRKACA/ITPR2/CREB1/ADORA1/GNAQ/PTGER4/AGTR1/AGT/PLCB2/CACNA1C/ADRB3/PTGER2/PDE3A/ADCY6/GUCY1A2/PDE3B/REN/KCNJ2	1.45850565588158
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	41/2910	110/9376	1.2009247110278	PIK3R1/PGR/ADCY1/AKT3/MAPK14/IGF1R/PRKACB/GNAI2/RPS6KA3/ADCY3/CDC25B/ANAPC13/CDC27/PIK3CA/MAPK1/CDC26/PRKACA/MAPK10/AKT2/ANAPC7/RAF1/IGF1/MAP2K1/MAPK8/KRAS/ARAF/MAD1L1/CDC16/ADCY7/ANAPC16/FZR1/ADCY9/PIK3CD/RPS6KA2/CPEB2/MAPK12/MAPK11/ANAPC2/ADCY6/PDE3B/PIK3R2	1.42199421502084
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	30/2910	78/9376	1.23922812582606	ACTG1/PIK3R1/CLTB/ILK/VCL/BCAR1/CAV2/WASF2/WASL/RHOG/SHC1/SRC/PIK3CA/SHC2/CRK/CLTC/WASF1/CTTN/PTK2/DNM1/ITGB1/DOCK1/RHOA/CAV1/PIK3CD/ELMO2/CLTCL1/ARHGEF26/SHC3/PIK3R2	1.42324298168229
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	13/2910	30/9376	1.39619702176403	MTR/ABCC3/RELA/FPGS/IKBKG/ABCC5/NFKB1/IKBKB/ABCC1/ABCC4/MTHFR/CHUK/FOLR2	1.45805272256337
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	29/2910	76/9376	1.22944474588533	APOA1/ILK/SORBS1/ACAA1/ACSL3/LPL/SCP2/PDPK1/ACSL1/CYP27A1/CPT1C/ACADM/ME3/NR1H3/PPARA/RXRB/SLC27A4/SLC27A1/MMP1/GK/CD36/ME1/FABP3/APOC3/SCD5/CPT1A/ACSL5/FABP4/ACOX2	1.34727956163299
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	20/2910	50/9376	1.28879725085911	IL15/CXCL12/IL15RA/HLA-DPB1/HLA-DQA2/HLA-DRA/HLA-DPA1/HLA-DMB/HLA-DMA/HLA-DQA1/LTBR/TNFSF13B/CD86/HLA-DQB1/CD40/HLA-DOA/HLA-DRB1/CXCR4/ITGA4/IL10	1.37355050815167
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	25/2910	65/9376	1.23922812582606	TRPC4/PIK3R1/AKT3/PRKCA/PIK3CA/MAPK1/SPP1/ITPR2/AKT2/RAF1/MAP2K1/GNA11/MAP2K2/KRAS/GNAQ/GABBR1/CACNA1G/TRPC1/ARRB2/PIK3CD/PLCB2/CACNA1C/KCNJ5/CACNA1H/PIK3R2	1.29832983014291
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	9/2910	20/9376	1.44989690721649	UGDH/CYB5R3/GMPPA/UAP1/CYB5R4/NANP/NPL/CYB5R2/UAP1L1	1.3511301383268
Organismal Systems	Nervous system	hsa04730	Long-term depression	23/2910	60/9376	1.23509736540664	LYN/IGF1R/GNAI2/PRKCA/MAPK1/PPP2CB/GNA13/ITPR2/PPP2CA/RAF1/IGF1/GNAO1/MAP2K1/GNA11/MAP2K2/GRIA3/KRAS/ARAF/GNAQ/PLCB2/PRKG1/GUCY1A2/CACNA1A	1.22552713068457
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	10/2910	23/9376	1.40086657702077	ATP6AP2/ACE/CTSA/ENPEP/ANPEP/PRCP/PREP/AGTR1/AGT/REN	1.29122694749365
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	36/2910	99/9376	1.17163386441737	HTR2B/PIK3R1/IL1R1/ADCY1/MAPK14/PRKACB/CALM2/BDKRB2/ADCY3/NTRK1/PRKCA/SRC/PIK3CA/BDKRB1/HRH1/PRKACA/MAPK10/ITPR2/IGF1/MAPK8/CAMK2D/GNAQ/ADCY7/PTGER4/ADCY9/PIK3CD/PLCG1/PLCB2/ASIC3/TRPV2/PTGER2/MAPK12/MAPK11/PLCG2/ADCY6/PIK3R2	1.15167803106978
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	159/2910	480/9376	1.0672852233677	TUBA1A/MAP3K5/WNT4/CAPN2/DAXX/WNT5A/UCHL1/MAP1LC3A/UBE2L6/TNFRSF1A/PRNP/MAPK14/COX7A1/COX6C/SNCAIP/DKK1/WNT5B/TNFRSF1B/WDR41/GPX1/CALM2/RB1CC1/OPTN/DCTN2/ATXN1/FAS/KIF5B/FADD/IFT57/ERN1/CAT/DERL1/KLC1/ACTR1A/TUBA3E/BCL2/DCTN6/ATP2A2/GPX7/WIPI1/ACTR10/PINK1/CSNK1E/DNALI1/BCL2L1/RELA/ULK1/TUBB2A/TANK/PPP3CB/BECN1/PRKCA/PSMC2/PPP3CC/PSMD3/ULK2/PSMD9/SDHD/WNT9A/MAPK1/HTRA2/ATXN2/CSNK2A1/ACTR1B/NDUFS1/WNT2/APC/CDK5/RAB5A/NFKB1/MAPK10/UBE2G2/ITPR2/NDUFS2/UBE2J1/DNAL4/WIPI2/CSF1/RAF1/FZD2/MAP2K1/DCTN1/MAP2K2/MAPK8/UBA1/NRBF2/GRIA3/KRAS/MFN1/BID/ARAF/ATXN3/CAMK2D/COX7A2L/GPX8/ATG13/BAD/WNT6/PSMC5/DNAL1/DCTN3/GNAQ/SPG11/FIG4/PSEN1/DVL2/MAP2K7/KIF5A/CSNK1A1/SQSTM1/APP/MAP1LC3B/GRIA4/ATG14/MFN2/PIK3C3/XBP1/EIF2AK3/HTT/PSEN2/ATXN1L/ZFYVE1/LRRK2/FZD3/LRP6/MAP3K10/ATG2B/NOX4/PLCG1/TOMM40L/KLC2/WNT3/PIK3R4/MTOR/HIP1/DLG4/MCU/FZD10/PLCB2/TUBB2B/FZD1/CYBB/CACNA1C/FZD4/UQCRB/ATG2A/TUBA3D/FZD8/MAPK12/MAPK11/STX1A/AMBRA1/NEFM/UBA7/KIF5C/UQCRQ/TUBA4A/FRAT1/NDUFA4L2	1.01521309878169
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	5/2910	10/9376	1.61099656357388	TST/PAPSS2/MPST/ETHE1/PAPSS1	1.29680887332425
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	86/2910	254/9376	1.09091105879806	SPHK1/PDGFRA/PDGFRB/F2R/HTR2B/VEGFA/MCOLN1/ATP2B4/PDGFD/ADCY1/CAMK1/EDNRA/TBXA2R/PRKACB/CALM2/FGF2/BDKRB2/EGFR/PLCD3/ORAI2/FGF7/EDNRB/ADCY3/NTRK1/STIM1/ORAI3/ATP2A2/VEGFB/MYLK/PLCD1/PPP3CB/PRKCA/PPP3CC/NFATC4/BDKRB1/ITPKC/HRH1/PRKACA/KDR/PDGFC/ITPR2/SLC8A1/VEGFC/GNA11/CD38/ASPH/CAMK1D/CAMK2D/TNNC2/GNAQ/FGF10/ADCY7/TPCN1/OXTR/CXCR4/AGTR1/ATP2B1/PTAFR/CACNA1G/SPHK2/ITPKB/PLCE1/ADORA2B/GNA15/ADCY9/PLN/STIM2/PLCG1/NTRK2/AVPR1A/TPCN2/PDGFA/MCU/PLCB2/P2RX7/CACNA1C/ADRB3/ITPKA/CACNA1H/GNA14/PLCG2/MCOLN3/CACNA1A/NFATC2/GNAL/NFATC1	0.985377911374482
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	41/2910	116/9376	1.13880791562981	GLUL/GNG4/HOMER3/ADCY1/PRKACB/GNG11/GNAI2/PLD1/ADCY3/GNB5/GNB2/PPP3CB/PRKCA/PPP3CC/MAPK1/SLC38A2/PRKACA/GNB1/ITPR2/GNAO1/GRIA3/GNG2/GNB4/GNAQ/ADCY7/DLGAP1/GRIA4/NCDN/TRPC1/ADCY9/HOMER2/GRIK2/SLC1A1/DLG4/PLCB2/CACNA1C/LZTS3/GNGT2/ADCY6/GNB3/CACNA1A	1.00914138414233
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	129/2910	388/9376	1.07122967371665	IRS2/TUBA1A/MAP3K5/WNT4/IRS1/APOE/CAPN2/BACE1/WNT5A/PIK3R1/RTN3/SLC39A6/TNFRSF1A/AKT3/COX7A1/COX6C/INSR/DKK1/WNT5B/CALM2/SLC39A13/RB1CC1/FAS/KIF5B/FADD/ERN1/RTN4/PSENEN/APH1A/KLC1/TUBA3E/SLC39A14/ATP2A2/WIPI1/CSNK1E/RELA/ULK1/TUBB2A/LRP1/PPP3CB/BECN1/ADAM10/PSMC2/LPL/PPP3CC/PSMD3/ULK2/PSMD9/SDHD/WNT9A/PIK3CA/APH1B/MAPK1/CSNK2A1/IKBKG/NDUFS1/WNT2/EIF2AK2/APC/CDK5/NFKB1/MAPK10/ITPR2/NDUFS2/AKT2/WIPI2/SLC39A3/CSF1/RAF1/FZD2/MAP2K1/IKBKB/SLC39A7/MAP2K2/MAPK8/NRBF2/APBB1/KRAS/IDE/BID/ARAF/COX7A2L/ATG13/BAD/WNT6/PSMC5/GNAQ/PSEN1/DVL2/MAP2K7/KIF5A/CSNK1A1/APP/ATG14/PIK3C3/XBP1/EIF2AK3/PSEN2/SLC39A11/SLC39A9/FZD3/CHUK/LRP6/ATG2B/NOX4/PIK3CD/KLC2/WNT3/PIK3R4/MTOR/MCU/FZD10/PLCB2/TUBB2B/FZD1/CYBB/CACNA1C/FZD4/UQCRB/ATG2A/TUBA3D/FZD8/AMBRA1/KIF5C/UQCRQ/TUBA4A/PIK3R2/FRAT1/NDUFA4L2	0.961301385931456
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	24/2910	65/9376	1.18965900079302	ALDH9A1/PNPLA2/LPL/MGLL/AGPAT1/LPIN1/AGPAT3/DGAT1/DGKH/LPIN2/AGPAT2/MBOAT2/AKR1A1/DGKE/ALDH3A2/AGPAT4/GK/LPIN3/DGKA/AGK/DGKQ/ABHD16A/DGKD/GPAT2	1.02931015086291
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	31/2910	86/9376	1.16141612722768	ITGB5/GJA1/SGCB/ITGB8/ACTG1/DTNA/SGCE/ITGAV/CACNB3/SNTB2/ATP2A2/CACNA2D1/TCF7L2/CDH2/EMD/CACNB2/SLC8A1/ITGB3/ITGA1/SSPN/ITGA3/SNTA1/ITGB1/ITGA2/LMNA/CACNB1/CACNA2D4/ACTN2/ITGA4/CACNA1C/SNTB1	1.00879419501937
NA	NA	hsa04519	Cadherin signaling	134/2910	404/9376	1.06868088870743	PDGFRA/PDGFRB/GJA1/CDH11/WNT4/RRAS/VIM/ACTG1/MRAS/WNT5A/ROCK2/TJP1/MAPK14/WNT5B/PCDH20/IGF1R/WTIP/LHFPL2/EGFR/CDH13/VCL/SHOC2/PSENEN/CREBBP/PRICKLE2/DAAM1/APH1A/LATS2/TAOK1/ABI2/RELA/DCHS1/ATN1/ADAM10/MYO1C/GABRA2/BRK1/TCF7L2/MYO1E/CDH2/WNT9A/APH1B/MAPK1/RRAS2/MOB1A/IKBKG/YAP1/WNT2/APC/WASF1/PCDH18/NFKB1/KDR/MAPK10/ARHGAP35/YWHAQ/NF2/PCDHB4/CIB2/PTK2/RAF1/FZD2/MAP2K1/IKBKB/MAP2K2/MAPK8/KRAS/SAV1/PRICKLE1/RYK/ROCK1/WNT6/EVL/PCDHB16/PCDHB15/PCDHB2/NCKAP1L/TEAD2/FAT4/WWTR1/KRT34/PSEN1/DVL2/CSNK1A1/SCN1B/PCDHGA5/KRT10/PCDHB14/CDH3/MOB1B/PSEN2/TMC1/TAOK2/CDH26/FZD3/CHUK/LRP6/RHOA/AJUBA/VAV1/MYO1F/PCDHGB6/ENAH/PCDHGC3/PCDHB10/RAC2/WNT3/PCDHGA12/LATS1/PCDHGB7/FZD10/FZD1/PCDHB5/FZD4/PCDH19/LHFPL3/GABRE/TMC8/PCDHB7/FZD8/PCDHB13/PCDHGA3/MAPK12/PCDHB12/MAPK11/PCDHB3/LIMA1/PCDHGA9/VANGL2/KRT86/GABRB3/CELSR1/MYO1D/FAT1	0.946664821432343
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	41/2910	117/9376	1.12907451464152	ACTG1/BAZ2B/MEAF6/CDK2AP1/CHD3/SMARCE1/SMARCA1/PBRM1/EPC1/RSF1/SMARCC2/CHD4/DPF2/SMARCD1/EPC2/PHF6/BCL7C/BPTF/INO80B/CDK2AP2/GATAD2B/BRD8/BAZ1B/ACTR8/INO80/SMARCD3/SS18/VPS72/INO80D/MRGBP/EP400/KAT5/SRCAP/PHF10/ARID1B/MTA1/ZNHIT1/BCL7A/MORF4L2/TRRAP/YY2	0.942465957220884
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	53/2910	154/9376	1.10886776453787	ATP2B4/ADCY1/AKT3/MAPK14/TPM2/PRKACB/CALM2/GNAI2/CACNB3/CREB3/ADCY3/CREB3L2/CREB3L1/BCL2/PPP2R3C/ATP2A2/CACNA2D1/TPM4/PRKCA/PPP2R5E/MAPK1/CACNB2/PPP2CB/PRKACA/ATF2/AKT2/ATF6B/PPP2CA/CREB1/SLC8A1/PPP2R5B/CREB5/PPP2R2D/CAMK2D/GNAQ/ADCY7/SCN1B/AGTR1/ATP2B1/ATP1B3/PPP2R3A/ADCY9/PLN/CACNB1/AGT/CACNA2D4/PIK3R5/PLCB2/CACNA1C/MAPK12/MAPK11/ADCY6/PIK3CG	0.913821537075812
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	76/2910	226/9376	1.08350211355412	FXYD1/RAP1B/RRAS/F2R/MYL9/PIK3R1/NPR1/ROCK2/ATP2B4/VIPR2/ADCY1/AKT3/EDNRA/PRKACB/CALM2/GNAI2/JUN/PLD1/CREB3/ADCY3/CREB3L2/CREB3L1/CREBBP/RAP1A/ATP2A2/PDE4B/RELA/PIK3CA/MAPK1/RRAS2/OXT/PRKACA/NFKB1/MAPK10/AKT2/CREB1/RAF1/MAP2K1/MAP2K2/MAPK8/CREB5/ADORA1/GRIA3/PPARA/PPP1R12A/CAMK2D/ROCK1/BAD/PDE4A/PTCH1/ADCY7/GABBR1/OXTR/GRIA4/ATP2B1/ATP1B3/ABCC4/PLCE1/RHOA/VAV1/PDE10A/ADCY9/PIK3CD/PLN/RAC2/POMC/CACNA1C/PTGER2/ARAP3/LIPE/PDE3A/ADCY6/SUCNR1/PDE3B/PIK3R2/NFATC1	0.852423518209287
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	12/2910	31/9376	1.24722314599268	ALDH9A1/SMOX/ALDH3B1/DPYD/HIBCH/HADHA/ALDH3A2/ABAT/ALDH6A1/MLYCD/CSAD/AOC3	0.924899629072326
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	30/2910	85/9376	1.13717404487568	ENPP1/DCTD/AK3/NTPCR/NT5E/NT5C3B/NME7/GUK1/NT5C/GMPR2/ENTPD4/NUDT16/NT5C3A/HPRT1/ENTPD3/NME3/TK2/NME4/NT5C2/UCK1/AK1/ASMTL/AK9/AMPD2/RRM2B/AMPD3/ENTPD5/GMPR/LACC1/CMPK2	0.852244996770638
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	28/2910	79/9376	1.14197224759668	ATP6V1D/CLTB/NAPA/ATP6V0D1/VAMP2/AP2M1/ATP6V0A1/STX2/STXBP1/CLTC/ATP6V0E1/ATP6V1H/AP2B1/ATP6V1C1/ATP6V1G1/TCIRG1/AP2A2/DNM1/ATP6V0B/SLC1A1/SYT1/CLTCL1/AP2S1/ATP6V1E2/STX1A/SLC6A12/ATP6V1G2/CACNA1A	0.85008014086064
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	16/2910	43/9376	1.19888116358987	ALDH9A1/ACAT1/ACAA1/ACAA2/ACSL3/ACSL1/HADHB/CPT1C/ACADM/HADHA/CYP2U1/ADH1B/ALDH3A2/ADH5/CPT1A/ACSL5	0.876862565145875
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	18/2910	49/9376	1.18358931201347	MAOB/GPSM1/PRKACB/GNAI2/MAOA/JUN/CREB3/CREB3L2/CREB3L1/RELA/CDK5/PRKACA/NFKB1/ATF2/ATF6B/CREB1/CREB5/DLG4	0.864348193285751
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	49/2910	144/9376	1.09637266132111	MAP3K5/PIK3R1/AKT3/RB1CC1/ATXN1/ERN1/ATP2A2/WIPI1/ULK1/RBPJ/BECN1/PRKCA/PSMC2/PSMD3/ULK2/PSMD9/RORA/PIK3CA/ATXN2/ATXN10/MAPK10/ITPR2/AKT2/WIPI2/MAPK8/NRBF2/GRIA3/ATXN3/ATG13/PSMC5/GNAQ/KAT5/ATG14/PIK3C3/XBP1/ATXN1L/SP1/ATG2B/PIK3CD/CIC/PIK3R4/MTOR/MCU/PLCB2/TBP/ATG2A/AMBRA1/CACNA1A/PIK3R2	0.781810471152262
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	29/2910	83/9376	1.12575663478657	SOD2/CAT/ACAA1/HMGCL/PEX2/ACSL3/PEX16/SCP2/MPV17/DHRS4/ACSL1/CRAT/PHYH/ABCD4/PEX19/PEX11B/PEX10/PEX26/GNPAT/PEX3/MLYCD/ABCD3/PEX11G/PEX1/NUDT12/PAOX/PEX6/ACSL5/ACOX2	0.771980388179272
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	21/2910	59/9376	1.14681111305259	ENPP1/DCTD/NT5E/DPYD/NT5C3B/NME7/NT5C/ENTPD4/CDADC1/NT5C3A/ENTPD3/NME3/TK2/NME4/NT5C2/UCK1/ASMTL/AK9/RRM2B/ENTPD5/CMPK2	0.758859144568899
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	16/2910	44/9376	1.17163386441737	TAF7/GTF2I/TAF12/GTF2F1/GTF2A1/TAF10/GTF2E2/CCNH/TAF6/GTF2H1/TAF1/TAF8/ERCC3/GTF2H2C/GTF2E1/TBP	0.765519462567099
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	14/2910	38/9376	1.18705009947549	GFPT2/HEXA/UGDH/GNPDA2/GNPDA1/PMM1/GMPPA/MPI/UAP1/AMDHD2/RENBP/FPGT/HK3/UAP1L1	0.775063150898126
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	20/2910	57/9376	1.13052390426237	ACAT1/ACAA1/ACAA2/ACSL3/SCP2/PPT1/ACSL1/MCAT/HSD17B12/HADHB/CPT1C/ACADM/HADHA/ACSF3/ELOVL4/FADS1/SCD5/CPT1A/ACSL5/ELOVL3	0.663066536456329
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	19/2910	54/9376	1.13366424844088	HLA-B/HLA-A/HLA-C/HLA-E/HLA-F/HLA-DPB1/HLA-DQA2/FAS/HLA-DRA/HLA-DPA1/HLA-DMB/HLA-DMA/HLA-DQA1/CD86/HLA-DQB1/CD40/HLA-DOA/HLA-DRB1/IL10	0.660802799140512
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	16/2910	45/9376	1.14559755631921	ABCA8/ABCA6/ABCC3/ABCA1/ABCB8/TAP1/ABCA9/ABCC5/ABCD4/ABCB7/ABCC9/ABCC1/ABCD3/ABCC4/ABCG1/ABCC10	0.656765801701284
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	13/2910	36/9376	1.16349751813669	ST6GALNAC2/GALNT15/GCNT1/ST6GALNAC4/GALNT7/GALNT11/C1GALT1C1/ST3GAL2/ST3GAL1/GALNT13/B4GALT5/GALNT10/ST6GALNAC3	0.659330641341129
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	36/2910	107/9376	1.08403507081607	FOXO1/AKT3/PRKACB/CALM2/CREB3/CREB3L2/CREB3L1/CREBBP/ACACB/PPP3CB/PPP3CC/PRKAG1/PRKAA1/PRKAG2/PRKACA/ATF2/ITPR2/AKT2/CREB1/CPT1C/FBP1/G6PC3/CREB5/PPARA/CAMK2D/PFKM/GNAQ/PYGB/SIK2/CRTC2/PLCB2/SIRT1/CPT1A/PYGM/PDE3B/PRKAA2	0.586476075970813
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	23/2910	67/9376	1.1060573421552	RAP1B/ADCY1/PRKACB/CALM2/RPS6KA3/CREBBP/RAP1A/PPP3CB/PRKCA/PPP3CC/MAPK1/PRKACA/ITPR2/RAF1/MAP2K1/MAP2K2/KRAS/ARAF/CAMK2D/GNAQ/RPS6KA2/PLCB2/CACNA1C	0.584441313393039
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	28/2910	83/9376	1.08693744048358	IFI16/POLR3GL/FADD/SAMHD1/POLR3D/RELA/DNASE2/IKBKG/CASP1/NFKB1/ADAR/PCBP1/IKBKB/POLR3H/IL18/PYCARD/MAVS/TREX1/ZDHHC1/MLKL/POLR3C/POLR3E/RIPK1/CXCL10/POLR3F/CHUK/POLR2L/IKBKE	0.533681576051503
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	24/2910	71/9376	1.08912443734572	PDGFRA/PDGFRB/PIK3R1/AKT3/EGFR/NTRK1/SCO2/HIF1A/PIK3CA/MAPK1/AKT2/RAF1/MAP2K1/MAP2K2/KRAS/PFKM/PTEN/MYC/SIRT6/PIK3CD/MTOR/SIRT3/HK3/PIK3R2	0.505687326244229
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	10/2910	28/9376	1.1507118311242	ATP6V1D/ATP6V0D1/ATP6V0A1/ATP6V0E1/ATP6V1C1/ATP6V1G1/TCIRG1/ATP6V1E2/SLC12A7/ATP6V1G2	0.535773578665499
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	25/2910	75/9376	1.07399770904926	ADCY1/GPX1/PRKACB/CREB3/ADCY3/CREB3L2/CREB3L1/GPX7/PRKCA/PRKACA/ATF2/ITPR2/ATF6B/CREB1/CREB5/GPX8/HSP90B1/GNAQ/ADCY7/TTF1/ATP1B3/ADCY9/PLCB2/ASGR1/ADCY6	0.431616825629615
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	6/2910	16/9376	1.20824742268041	HEXA/A4GALT/ST3GAL2/GBGT1/ST3GAL1/B3GALT5	0.559262866957686
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	23/2910	69/9376	1.07399770904926	MAOB/PRKACB/CALM2/MAOA/JUN/CREB3/CREB3L2/CREB3L1/PPP3CB/PRKCA/PPP3CC/PRKACA/ATF2/ATF6B/CREB1/CREB5/GRIA3/CAMK2D/ARC/GRIA4/SIRT1/CACNA1C/STX1A	0.413858848689669
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	13/2910	38/9376	1.10226080665581	IRS1/PIK3R1/INSR/PRKCA/PIK3CA/MAPK1/PDPK1/IGF1/KRAS/SGK1/ATP1B3/PIK3CD/PIK3R2	0.42372916797312
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	51/2910	158/9376	1.04001043977554	CHEK2/GADD45G/ABL1/ATRX/CREBBP/CDC25B/ANAPC13/CDK4/CDKN2B/RB1/PPP2R5E/SMAD2/CDC27/NIPBL/PPP2CB/CDC26/CCNH/ESCO1/STAG1/RBL2/ANAPC7/YWHAQ/PPP2CA/PDS5B/SMAD4/PPP2R5B/CCND2/CDKN1B/MAD2L1BP/MAD1L1/STAG2/CDC16/SMAD3/ATM/TGFB2/ANAPC16/CDKN2C/MYC/FZR1/CDKN2D/ATR/MAU2/GADD45B/ZBTB17/CDKN1A/CDC7/CDC14B/GADD45A/CDC14A/TGFB3/ANAPC2	0.340249737718563
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	14/2910	42/9376	1.07399770904926	MAOB/AOC1/ALDH9A1/CYP1B1/AOX1/MAOA/ACAT1/CAT/DLST/HADHA/IL4I1/ALDH3A2/HAAO/INMT	0.322420987486734
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	6/2910	17/9376	1.13717404487568	PCDH20/LAMP1/LAMP2/MYH11/MYH9/CLEC4M	0.379748410346109
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	54/2910	170/9376	1.02345664038811	TUBA1A/MAP3K5/MYL9/MYL6/ACTG1/MSN/ROCK2/YBX3/TJP1/JAM2/RAB13/PRKACB/JUN/MAGI1/RAP1A/TUBA3E/CDK4/ARHGEF2/PRKAG1/SRC/PRKAA1/PPP2CB/PRKAG2/CTTN/PRKACA/MYL6B/MAPK10/NF2/PPP2CA/MAPK8/STK11/WHAMM/CD1D/PPP2R2D/PRKCI/ROCK1/MYH11/MYH9/MAP2K7/CLDN10/ITGB1/PARD6G/RUNX1/CLDN23/RHOA/ARHGEF18/DLG3/TUBA3D/CLDN12/MYL12B/PARD6A/TUBA4A/CLDN15/PRKAA2	0.207047059851241
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	75/2910	238/9376	1.015333968639	C3/C1S/PIK3R1/C1R/C2/STAT3/ACE/TNFRSF1A/MAPK14/STAT1/IFNAR1/EGFR/IL6ST/JAK1/JUN/CFD/MYD88/MX2/C1QB/RELA/MASP1/PRKCA/C1QA/MX1/PIK3CA/MAPK1/STAT2/OAS2/IKBKG/CASP1/EIF2AK2/IL6R/NFKB1/ADAR/MAPK10/OAS1/RPL36AL/IKBKB/MAPK8/C1QC/MAP3K7/C3AR1/IRAK1/NRP1/TRAF3/TLR4/MAVS/IRAK4/TAB2/SYK/AGTR1/FCGR2A/MMP1/CXCL10/TRAF6/TLR7/CHUK/RPS4Y1/PIK3CD/IRF9/IFIH1/TLR2/PLCG1/FGG/HBEGF/MMP3/CYBB/IKBKE/MAPK12/MAPK11/C5AR1/TYK2/PLCG2/C5/PIK3R2	0.160742883587338
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	9/2910	27/9376	1.07399770904926	ACAT1/HMGCL/HADHA/OXCT1/ABAT/AACS/ACSM5/ALDH5A1/OXCT2	0.258304432684346
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	19/2910	59/9376	1.03759100704759	GSTT1/GGT5/GSTM3/MGST1/GPX1/ANPEP/GPX7/TXNDC12/PGD/LAP3/GPX8/GSTM5/LANCL1/GSTO1/RRM2B/GCLC/GGT7/CHAC2/OPLAH	0.194305995360139
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	12/2910	37/9376	1.04497074393982	APOA1/VCAM1/LAMA4/APOL1/FAS/MYD88/PRKCA/IL18/GNAQ/ICAM1/IL10/PLCB2	0.183863290822179
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	20/2910	63/9376	1.02285496099929	POLD4/ERCC1/CETN2/XPC/RFC1/ERCC4/POLR2B/XPA/CCNH/POLR2C/POLR2A/GTF2H1/POLR2M/ERCC5/POLR2J3/ERCC3/DDB2/GTF2H2C/POLR2L/ERCC8	0.122101286637838
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	6/2910	18/9376	1.07399770904926	ACACB/ACSL3/ACSL1/MCAT/ACSF3/ACSL5	0.210803243574678
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	10/2910	31/9376	1.03935262166057	H6PD/DERA/PGD/FBP1/IDNK/PGLS/RBKS/PFKM/PRPS1/RGN	0.147224180934748
NA	NA	hsa04981	Folate transport and metabolism	10/2910	31/9376	1.03935262166057	MTR/ABCC3/FPGS/ABCC5/BHMT2/SLCO2B1/ABCC1/ABCC4/MTHFR/FOLR2	0.147224180934748
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	36/2910	115/9376	1.00862393545495	GNG4/MAOB/HTR2B/KCND2/PRKACB/GNG11/GNAI2/DUSP1/MAOA/GNB5/GNB2/PRKCA/MAPK1/PRKACA/GNB1/ITPR2/RAF1/GNAO1/MAP2K1/KRAS/ARAF/ALOX5/GNG2/GNB4/GNAQ/APP/TRPC1/PTGS1/PLCB2/CACNA1C/KCNJ5/GNGT2/ALOX15B/GNB3/CACNA1A/GABRB3	0.0624222987774517
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	17/2910	54/9376	1.01433116965763	REV3L/ERCC1/POLK/ERCC4/WDR48/MUS81/REV1/FANCF/PMS2/ATR/FAN1/PALB2/POLI/HES1/SLX4/TOP3B/POLN	0.0708497383195785
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	12/2910	38/9376	1.01747151383614	TAP1/UNG/IKBKG/CD4/CD40/PTPRC/BTK/CIITA/RFX5/IL2RG/JAK3/RFXAP	0.0723951850481134
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	4/2910	12/9376	1.07399770904926	COQ2/VKORC1L1/NQO1/VKORC1	0.172064975648973
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	4/2910	12/9376	1.07399770904926	CLEC4M/NCAM1/NCAM2/ASGR1	0.172064975648973
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	11/2910	35/9376	1.0126264113893	HSD17B14/PMM1/GMPPA/FBP1/MPI/PFKM/PFKFB3/SORD/FPGT/HK3/PFKFB2	0.0502032177521784
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	7/2910	22/9376	1.0251796313652	MAOB/AOC1/ALDH9A1/MAOA/HNMT/ALDH3B1/ALDH3A2	0.0793188315273547
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	70/2910	227/9376	0.99356616255658	NFE2L2/MAP3K5/GSTT1/VEGFA/PIK3R1/AKT3/MAPK14/COX7A1/COX6C/GSTM3/CYP1B1/MGST1/ABL1/EGFR/JUN/PLD1/SOD2/PTPN11/CAT/RELA/HIF1A/SRC/SDHD/PIK3CA/MAPK1/KEAP1/PDPK1/PTPN1/IKBKG/NDUFS1/NFKB1/MAPK10/NDUFS2/AKT2/PTK2/RAF1/MAP2K1/IKBKB/MAP2K2/MAPK8/KRAS/ARAF/COX7A2L/AKR1A1/NCF2/BAD/SOS2/PTEN/ABL2/MAP2K7/NQO1/GSTM5/SOS1/GSTO1/PRKD1/FOXO3/PRKD2/CHUK/MAP2K4/AHR/NOX4/PIK3CD/UQCRB/MAPK12/CYBA/MAPK11/PTPRJ/UQCRQ/PIK3R2/NDUFA4L2	-0.0658279728315296
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	16/2910	52/9376	0.991382500660851	ADCY1/INSR/CYP1B1/IGF1R/PRKACB/ADCY3/PRKACA/IGF1/ALOX5/ADCY7/SCARB1/STAR/LDLR/ADCY9/ACOT2/ADCY6	-0.041801905653745
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	33/2910	108/9376	0.984497899961818	EEF1A1/KPNA3/PHAX/NCBP2/RANBP2/THOC2/NUP214/UBE2I/UPF2/SEC13/DDX19B/UPF3A/SUMO1/KPNA6/ACIN1/SUMO3/KPNA1/DDX39B/THOC5/CASC3/KPNA5/AHCTF1/POM121C/SUMO2/DDX19A/TPR/IPO8/IPO13/GLE1/NUP35/NUP133/XPO4/RANBP17	-0.108698533005603
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	48/2910	157/9376	0.985067962440081	IRS2/MAP3K5/IRS1/PIK3R1/TNFRSF1A/AKT3/MAPK14/COX7A1/COX6C/INSR/JUN/FAS/ERN1/RELA/PRKAG1/SDHD/PIK3CA/PRKAA1/PRKAG2/NDUFS1/MLXIP/IL6R/NFKB1/MAPK10/NDUFS2/MLX/AKT2/IKBKB/MAPK8/NR1H3/PPARA/BID/COX7A2L/GSK3A/SOCS3/XBP1/SREBF1/EIF2AK3/BCL2L11/LEPR/PIK3CD/UQCRB/MAPK12/MAPK11/UQCRQ/PIK3R2/PRKAA2/NDUFA4L2	-0.126573058636037
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	5/2910	16/9376	1.00687285223368	MAOB/MAOA/ALDH3B1/IL4I1/AOC3	0.0184575203616398
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	4/2910	13/9376	0.991382500660851	RAD50/LIG4/POLL/POLM	-0.0208573777034164
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	45/2910	149/9376	0.97308517262852	GNG4/ADCY1/MAPK14/PRKACB/GNG11/GNAI2/CNR1/ADCY3/GNB5/GNB2/PRKCA/GABRA2/MGLL/MAPK1/NDUFS1/PRKACA/GNB1/MAPK10/ITPR2/NDUFS2/GNAO1/MAPK8/GRIA3/GNG2/GNB4/GNAQ/ADCY7/DAGLB/GRIA4/ADCY9/ABHD6/NAPEPLD/PLCB2/CACNA1C/KCNJ5/GABRE/DAGLA/MAPK12/MAPK11/GNGT2/ADCY6/GNB3/CACNA1A/GABRB3/NDUFA4L2	-0.222161477523544
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	30/2910	100/9376	0.96659793814433	CXCL12/TNFRSF1A/TNFRSF1B/IL6ST/TNFRSF14/ACKR4/LTBR/IL6R/CSF1/CCL8/IL18/CCL26/CXCR4/CXCL10/IL19/IL2RA/CXCL9/PPBP/CCL18/IL2RG/TNFRSF10D/IL10/IL18R1/PF4/TNFSF14/XCL2/CX3CR1/ACKR3/CCL7/XCL1	-0.225271986365011
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	14/2910	47/9376	0.959742633618484	ALDH9A1/ACAT1/PC/ACYP2/ACACB/HAGH/GRHPR/ME2/ME3/AKR1A1/ADH1B/ALDH3A2/ADH5/ME1	-0.18560557851287
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	8/2910	27/9376	0.954664630266005	ACAA1/SCP2/HSD17B12/ELOVL4/FADS1/SCD5/ACOT2/ELOVL3	-0.158252560925635
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	13/2910	44/9376	0.951952514839113	POLD4/PARP4/MPG/UNG/RFC1/MBD4/OGG1/APTX/PARP3/PNKP/POLL/APEX1/POLG	-0.214300861563196
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	90/2910	298/9376	0.97308517262852	PRLR/IFNGR2/IL15/TNFRSF12A/IL13RA1/IL1R1/CXCL12/IL15RA/PRL/OSMR/TNFRSF1A/TNFSF12/IFNAR1/CLCF1/TGFBR2/TNFRSF1B/TNFRSF8/IL32/IL6ST/TGFBR1/FAS/IFNGR1/TNFRSF21/INHBB/TNFRSF14/BMPR2/RELL1/IL17RC/IL4R/ACVR1/ACKR4/CTF1/LTBR/TNFSF13B/IL6R/BMP4/IL1RL1/CSF1/BMPR1A/IL13RA2/CCL8/CXCL16/IL18/TNFRSF11B/IL11/CD4/IL16/CD40/IL1R2/TGFB2/CCL26/GDF7/CXCR4/CXCL10/ACVR1B/IL19/EPOR/CSH1/IL2RA/CXCL9/PPBP/IL17RE/CCL18/IL17RA/LEPR/INHBA/IL2RG/ACVR2A/THPO/TNFRSF10D/IL12RB1/IL10/IL18R1/IL27RA/BMP2/TGFB3/PF4/CSH2/IL1RL2/TNFSF15/TNFSF14/OSM/XCL2/CX3CR1/ACKR3/TNFRSF18/CCL7/LIF/XCL1/RELL2	-0.316751677846417
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	5/2910	17/9376	0.947645037396402	HSD3B7/SCP2/CYP27A1/CYP7B1/ACOX2	-0.144937869554439
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	7/2910	24/9376	0.939747995418099	EXT2/B3GALT6/HS2ST1/EXT1/NDST2/EXTL3/NDST1	-0.198261850218309
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	20/2910	68/9376	0.947645037396402	DHRS3/ALDH1A1/RDH10/ALDH1A2/AOX1/RDH11/DHRS4/DGAT1/PNPLA4/ALDH1A3/ADH1B/HSD17B6/CYP2A6/CYP2A7/ADH5/RETSAT/CYP27C1/DHRS4L2/RDH12/RDH5	-0.29066879172374
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	9/2910	31/9376	0.935417359494513	SEC62/SEC63/TMEM208/OXA1L/SPCS2/SEC61A1/SEC61B/SEC61A2/SEC61G	-0.241613543134041
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	6/2910	21/9376	0.920569464899362	ENPP1/DPYD/BCAT1/PANK2/ALDH3A2/CSAD	-0.24444970769226
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	8/2910	28/9376	0.920569464899362	ACAA2/PPT1/HSD17B12/HADHB/HADHA/ELOVL4/ACOT2/ELOVL3	-0.282371873055627
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	25/2910	86/9376	0.936625909054583	ADCY1/PRKACB/CREB3/ADCY3/CREB3L2/CREB3L1/VAMP2/PRKCA/PRKACA/ATF2/ATF6B/CREB1/GNA11/CREB5/KCNMB1/CAMK2D/GNAQ/ADCY7/ATP1B3/ADCY9/PLCB2/RIMS2/CACNA1C/STX1A/ADCY6	-0.396065846445371
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	92/2910	308/9376	0.962413531485696	TUBA1A/MAP3K5/TGM2/COX7A1/COX6C/GPX1/CLTB/RB1CC1/DCTN2/SOD2/KIF5B/IFT57/CREB3/ERN1/CREB3L2/CREB3L1/CREBBP/AP2M1/KLC1/ACTR1A/TUBA3E/DCTN6/GPX7/WIPI1/ACTR10/DNALI1/ULK1/TUBB2A/BECN1/PSMC2/PSMD3/ULK2/PSMD9/SDHD/POLR2B/CLTC/ACTR1B/NDUFS1/MAPK10/NDUFS2/AP2B1/POLR2C/CREB1/DNAL4/WIPI2/DCTN1/MAPK8/CREB5/POLR2A/NRBF2/GRIA3/COX7A2L/GPX8/REST/ATG13/PSMC5/DNAL1/DCTN3/GNAQ/MAP2K7/AP2A2/KIF5A/GRIA4/ATG14/PIK3C3/HTT/POLR2J3/SP1/MAP3K10/ATG2B/SIN3A/POLR2L/KLC2/PIK3R4/MTOR/HIP1/DLG4/PLCB2/TUBB2B/CLTCL1/TBP/AP2S1/UQCRB/ATG2A/TUBA3D/STX1A/AMBRA1/KIF5C/UQCRQ/TUBA4A/NRF1/NDUFA4L2	-0.449951193375753
Organismal Systems	Digestive system	hsa04970	Salivary secretion	27/2910	93/9376	0.935417359494513	CST3/ATP2B4/ADCY1/SLC4A2/PRKACB/CALM2/BST1/ADCY3/VAMP2/LYZ/PRKCA/PRKACA/ITPR2/CD38/GNAQ/ADCY7/CAMP/ATP2B1/CST2/ATP1B3/SLC12A2/ADCY9/PLCB2/ADRB3/PRKG1/ADCY6/GUCY1A2	-0.41988211784617
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	5/2910	18/9376	0.89499809087438	MTR/THAP11/ABCD4/TCN2/MMAA	-0.299127409613191
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	14/2910	50/9376	0.902158075601375	MAOB/P4HA3/AOC1/SAT1/ALDH9A1/SMOX/MAOA/SAT2/OAT/PYCR2/L3HYPDH/LAP3/ALDH3A2/CKM	-0.465346621467092
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	57/2910	195/9376	0.941813375627809	C3/ACTG1/PIK3R1/AKT3/MAPK14/HDAC7/FCGR3A/RELA/PRKCA/ATG7/SELPLG/SRC/PIK3CA/MAPK1/CLCN3/CASP1/FPR3/NFKB1/AKT2/ITGB3/RAF1/MAP2K1/MAP2K2/MAP3K7/NCF2/ITGB2/HDAC3/TLR4/SIGLEC9/CAMP/SYK/HDAC4/FCGR2A/FCGR1A/CR1/HDAC11/TLR7/PIK3CD/TLR2/PLCG1/RAC2/ITGAM/MTOR/FGG/PLCB2/ITGAL/CYBB/MAPK12/CYBA/MAPK11/C5AR1/PLCG2/AQP9/C5/CLCN5/HDAC9/PIK3R2	-0.550820071658476
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	69/2910	235/9376	0.946032024566791	MAP3K5/ACTG1/NPR1/RHEB/ADCY1/MAPK14/COX7A1/COX6C/PRKACB/ZNF516/RPS6KA3/SMARCE1/CNR1/CREB3/ADCY3/CREB3L2/CREB3L1/SMARCC2/PNPLA2/ACSL3/MGLL/PRKAG1/SDHD/NDUFAF3/PRKAA1/ACSL1/SMARCD1/PRKAG2/NDUFS1/PRKACA/ATF2/NDUFS2/CREB1/COA5/SLC25A29/CPT1C/CREB5/NDUFAF7/KRAS/FRS2/COX7A2L/COX11/SMARCD3/AKT1S1/SOS2/SLC25A20/RPS6KB1/ADCY7/SOS1/ARID1B/SIRT6/ADCY9/NDUFAF5/RPS6KA2/MTOR/TSC2/CPT1A/ACSL5/ADRB3/UQCRB/PRKG1/KDM3A/MAPK12/MAPK11/LIPE/ADCY6/UQCRQ/PRKAA2/NDUFA4L2	-0.562066220325743
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	22/2910	78/9376	0.908767292272447	TOB1/LSM1/DDX6/CNOT4/XRN1/XRN2/C1D/EXOSC4/CNOT2/DCP1B/NUDT16/CNOT8/ZCCHC7/PFKM/DHX36/CNOT6L/PABPC5/CNOT10/DIS3L/ENO2/BTG2/PABPC1	-0.542771927526278
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	10/2910	37/9376	0.87080895328318	GFPT2/UGDH/PMM1/GMPPA/MPI/UAP1/NANP/FPGT/HK3/UAP1L1	-0.528198755748968
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	6/2910	23/9376	0.840519946212461	ACAT1/PCYOX1/FNTA/GGPS1/RCE1/DHDDS	-0.513699457232471
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	29/2910	103/9376	0.907163113468789	SLC7A8/COL12A1/CPB1/COL15A1/COL18A1/COL7A1/COL6A3/COL4A4/COL5A2/SLC7A7/PRCP/SLC38A2/COL8A1/SLC8A1/SLC3A2/SLC36A4/COL5A1/COL5A3/COL4A6/ATP1B3/COL4A3/COL4A5/SLC1A1/COL23A1/COL24A1/COL17A1/ELN/COL6A2/SLC16A10	-0.635540647519787
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	39/2910	138/9376	0.910563275063499	PGR/ADCY1/MAPK14/IGF1R/PRKACB/CALM2/FBXW11/RPS6KA3/ADCY3/SLK/ANAPC13/PPP3CB/PPP3CC/PPP2R5E/CDC27/MAPK1/PPP2CB/CDC26/PRKACA/AR/ITPR2/ANAPC7/YWHAQ/PPP2CA/PPP2R5B/IGF1/MAP2K1/MAD1L1/CAMK2D/CDC16/ADCY7/ANAPC16/ADCY9/RPS6KA2/CPEB2/MAPK12/MAPK11/ANAPC2/ADCY6	-0.710036597685486
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	5/2910	20/9376	0.805498281786942	LIPA/SOAT1/LSS/SOAT2/CYP2R1	-0.584127450575137
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	8/2910	31/9376	0.831482097328456	HSD17B14/ALDH9A1/UGDH/GUSB/AKR1A1/ALDH3A2/RGN/KL	-0.63045126720283
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	4/2910	17/9376	0.758116029917121	GGT5/ADO/CSAD/GGT7	-0.669624149454986
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	4/2910	17/9376	0.758116029917121	GLUL/GLUD1/CA5B/CA12	-0.669624149454986
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	8/2910	32/9376	0.805498281786942	ACACB/SUCLA2/HIBCH/HADHA/ACSS3/ABAT/ALDH6A1/MLYCD	-0.739343567997594
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	28/2910	103/9376	0.875881626797451	PPP2R3C/SMG6/NCBP2/PELO/PPP2R5E/GSPT2/WDR82/PPP2CB/PPP2CA/PPP2R5B/UPF2/DDX19B/UPF3A/ACIN1/PPP2R2D/CSTF2T/DDX39B/CASC3/CSTF1/CPSF7/DDX19A/CLP1/PABPC5/PPP2R3A/PAPOLG/GLE1/MSI1/PABPC1	-0.849686737908112
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	13/2910	51/9376	0.821292365743548	PLA2G7/PLD1/CHPT1/PAFAH1B1/PLD3/TMEM86A/PAFAH1B2/LPCAT2/ENPP2/CEPT1/PAFAH2/PLD4/TMEM86B	-0.85845603086605
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	9/2910	37/9376	0.783728057954862	MAOB/AOX1/MAOA/ALDH3B1/FAHD1/IL4I1/ADH1B/ADH5/AOC3	-0.884229779034542
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	10/2910	41/9376	0.785851982231163	POLD4/NBN/RAD50/UIMC1/MUS81/ATM/RBBP8/PALB2/TOP3B/RAD51B	-0.921856046389149
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	6/2910	26/9376	0.743536875495638	APOA1/BTD/ABCD4/SCARB1/ABCC1/TCN2	-0.878456134745446
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	104/2910	368/9376	0.910563275063499	TUBA1A/MAP3K5/ACTG1/DAXX/MAP1LC3A/TNFRSF1A/MAPK14/COX7A1/COX6C/TNFRSF1B/WDR41/ANG/GPX1/RB1CC1/OPTN/DCTN2/KIF5B/ERN1/CAT/DERL1/KLC1/ACTR1A/ANXA7/TUBA3E/BCL2/DCTN6/GPX7/WIPI1/ACTR10/PINK1/SETX/DNALI1/BCL2L1/ULK1/TUBB2A/TANK/PFN2/PPP3CB/BECN1/PSMC2/PPP3CC/PSMD3/ULK2/PSMD9/SDHD/RANBP2/MATR3/ATXN2/UBQLN1/CASP1/ACTR1B/NDUFS1/NUP214/RAB5A/NDUFS2/DNAL4/WIPI2/DCTN1/SEC13/NRBF2/BID/ANXA11/COX7A2L/GPX8/ATG13/BAD/PSMC5/UBQLN2/DNAL1/DCTN3/SPG11/FIG4/KIF5A/SQSTM1/MAP1LC3B/ATG14/PIK3C3/POM121C/XBP1/TPR/EIF2AK3/GLE1/ATG2B/UBQLN4/TOMM40L/NUP35/KLC2/PIK3R4/MTOR/MCU/TUBB2B/NUP133/UQCRB/ATG2A/TUBA3D/MAPK12/MAPK11/AMBRA1/NEFM/KIF5C/UQCRQ/TUBA4A/PFN4/NDUFA4L2	-1.17419409135137
Organismal Systems	Digestive system	hsa04978	Mineral absorption	15/2910	61/9376	0.792293391921582	CYBRD1/ATP2B4/HEPH/FTH1/SLC8A1/TRPM7/FTL/SLC40A1/ATP2B1/ATOX1/VDR/ATP1B3/ATP7A/STEAP1/STEAP2	-1.09178741538744
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	56/2910	205/9376	0.880154220098902	IRS1/PIK3R1/GFPT2/ACE/AKT3/MAPK14/COX7A1/COX6C/INSR/CTSD/TGFBR2/TGFBR1/MMP2/ATP2A2/RELA/PRKCA/SMAD2/MPC1/SDHD/PIK3CA/NDUFS1/NFKB1/MAPK10/NDUFS2/AKT2/TBC1D4/PDK4/MAPK8/PPARA/CAMK2D/COX7A2L/NCF2/SMAD3/PTEN/TGFB2/PDK2/AGTR1/MMP9/SP1/CD36/PIK3CD/PLN/RAC2/AGT/MTOR/PLCB2/CYBB/UQCRB/TGFB3/MAPK12/CYBA/MAPK11/UQCRQ/REN/PIK3R2/NDUFA4L2	-1.16387305073871
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	19/2910	76/9376	0.805498281786942	ACTG1/ADCY1/SLC4A2/PRKACB/CALM2/GNAI2/ADCY3/MYLK/PRKCA/PRKACA/ITPR2/CAMK2D/GNAQ/ADCY7/ATP1B3/ADCY9/PLCB2/ADCY6/KCNJ2	-1.14209714691796
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	10/2910	43/9376	0.749300727243667	APOA1/ABCA1/ACAT1/AGPAT1/DGAT1/AGPAT2/SCARB1/SLC27A4/SLC27A1/CD36	-1.10532743987085
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	6/2910	28/9376	0.690427098674521	B4GALT3/B4GALT2/A4GALT/ST3GAL3/B3GALT5/FUT4	-1.10051732477675
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	8/2910	36/9376	0.715998472699504	ENPP1/PGM2L1/GANC/GYG1/G6PC3/PYGB/HK3/PYGM	-1.14528288423524
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	11/2910	48/9376	0.738373424971363	PIK3R1/AKT3/PIK3CA/AKT2/G6PC3/ATP1B3/PIK3CD/PLCB2/HK3/SLC2A5/PIK3R2	-1.21905272162391
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	8/2910	37/9376	0.696647162626544	GLUL/GFPT2/ASS1/GLUD1/ASL/IL4I1/ABAT/ALDH5A1	-1.24026080232012
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	9/2910	41/9376	0.707266784008046	MAOB/SDSL/MAOA/GRHPR/SDS/SRR/AOC3/SARDH/DMGDH	-1.26014654701321
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	40/2910	154/9376	0.836881331726692	DHRS3/UGDH/AK3/RDH11/COQ2/GUSB/MOCS2/VKORC1L1/FPGS/NME7/PMM1/BCAT1/PANK2/UROD/GMPPA/MPI/NADK/PPOX/AKR1A1/ALDH3A2/NME3/HAAO/PNPO/NME4/NQO1/MTHFD2L/AK1/VKORC1/HSD17B6/SPR/AK9/NMNAT1/LIPT1/GCLC/RGN/NADSYN1/CMPK2/NMNAT2/GPHN/RDH12	-1.3691964081381
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	6/2910	30/9376	0.644398625429553	PC/SUCLA2/SDHD/DLST/ACO2/ACO1	-1.30865585518843
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	25/2910	102/9376	0.789704197830335	RAP1B/CPB1/ATP2B4/ADCY1/SLC4A2/BST1/ADCY3/RAP1A/ATP2A2/PRKCA/ITPR2/CD38/RAB27B/GNAQ/ADCY7/ATP2B1/ATP1B3/TRPC1/RHOA/SLC12A2/ADCY9/RAB3D/TPCN2/PLCB2/ADCY6	-1.43255540056494
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	6/2910	31/9376	0.623611572996342	GLUL/ACAT1/CAT/GRHPR/ACO2/ACO1	-1.40812671534041
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	87/2910	323/9376	0.867843350036705	PDGFRA/IRS2/CD44/PDGFRB/ZEB1/TNXB/MARCKS/VEGFA/IRS1/TIMP3/VIM/THBS1/PIK3R1/PIM1/STAT3/PLAU/FOXP1/CYP1B1/MAPK7/ABL1/EGFR/CREBBP/BMPR2/BCL2/CDC25B/PRKCA/SHC1/SOCS1/PIK3CA/MAPK1/BMI1/TNC/CRK/APC/SPRY2/UBE2I/NFKB1/RECK/EFNA5/ZEB2/ITGB3/RAF1/MAP2K1/IKBKB/MAP2K2/CCND2/SOX4/CDKN1B/RASSF1/KRAS/DICER1/HOXD10/ROCK1/NOTCH2/SOS2/ATM/PTEN/MIR29A/DDIT4/ABCC1/TGFB2/MYC/NOTCH1/HDAC4/SLC45A3/SOS1/NOTCH3/MMP9/FZD3/BCL2L11/RHOA/CDKN1A/PIK3CD/PLCG1/BCL2L2/WNT3/PDGFA/MTOR/NOTCH4/SIRT1/ST14/MCL1/MIR145/BMF/PLCG2/PIK3R2/ZFPM2	-1.62146771073744
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	19/2910	82/9376	0.746559383119604	GSTT1/GSTM3/MGST1/GUSB/DPYD/NME7/CES2/CDADC1/HPRT1/NME3/TK2/NME4/UCK1/GSTM5/GSTO1/CYP2A6/RRM2B/CYP2A7/NAT1	-1.54630831654967
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	4/2910	23/9376	0.560346630808307	GLUL/ASS1/GLUD1/ASL	-1.41616265959553
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	4/2910	23/9376	0.560346630808307	POLD4/RFC1/MLH3/PMS2	-1.41616265959553
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	7/2910	36/9376	0.626498663612066	UGDH/FGGY/GUSB/AKR1A1/CRYL1/SORD/KL	-1.50620558935052
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	6/2910	32/9376	0.604123711340206	GANC/GLB1/B4GALT2/G6PC3/PFKM/HK3	-1.50481235041206
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	5/2910	28/9376	0.575355915562101	MOCS2/FPGS/PCBD1/SPR/GPHN	-1.50959005063732
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	2/2910	15/9376	0.429599083619702	NTPCR/AK1	-1.48312926353179
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	9/2910	46/9376	0.630389959659346	PSMB8/PSMB9/PSMF1/PSMC2/PSMD3/PSMD9/PSMB10/PSMC5/PSME4	-1.6857615219568
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	27/2910	116/9376	0.749946676146463	H6PD/SDSL/ACAT1/PC/CAT/SUCLA2/SDHD/HIBCH/GLUD1/PGD/DLST/ACO2/FBP1/ME2/ME3/IDNK/PGLS/SDS/PFKM/ACO1/ALDH6A1/PRPS1/ADH5/ME1/RGN/ENO2/HK3	-1.81790178318008
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	7/2910	39/9376	0.57830645871883	MTR/BHMT2/MTHFD2L/MTHFR/ALDH1L2/SARDH/DMGDH	-1.77027141196988
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	70/2910	275/9376	0.820143705092159	TUBA1A/FYN/PIK3R1/PRNP/MAPK14/COX7A1/COX6C/PRKACB/LAMC1/KIF5B/CREB3/CREB3L2/CREB3L1/KLC1/TUBA3E/CAV2/C1QB/TUBB2A/PPP3CB/PSMC2/C1QA/PPP3CC/PSMD3/PSMD9/SDHD/PIK3CA/MAPK1/CSNK2A1/NDUFS1/PRKACA/MAPK10/ATF2/ITPR2/NDUFS2/ATF6B/CREB1/MAPK8/CREB5/C1QC/COX7A2L/NCF2/BAD/PSMC5/KIF5A/NOTCH1/EIF2AK3/HSPA1A/NCAM1/CAV1/PIK3CD/RAC2/NCAM2/KLC2/MCU/TUBB2B/CYBB/CACNA1C/UQCRB/TUBA3D/MAPK12/CYBA/MAPK11/KIF5C/HSPA1B/C5/HSPA6/UQCRQ/TUBA4A/PIK3R2/NDUFA4L2	-2.03077456284082
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	10/2910	54/9376	0.596665393916253	TST/SDSL/MTR/MPST/BCAT1/SDS/BHMT2/IL4I1/GCLC/LACC1	-1.99398597455369
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	18/2910	87/9376	0.666619267685745	COX7A1/COX6C/TPM2/CACNB3/ATP2A2/CACNA2D1/TPM4/CACNB2/SLC8A1/ASPH/COX7A2L/ATP1B3/CACNB1/CACNA2D4/CACNA1C/UQCRB/SLC9A6/UQCRQ	-2.09570390998212
Organismal Systems	Sensory system	hsa04744	Phototransduction	4/2910	29/9376	0.44441284512383	CALM2/GNB1/PDE6B/RCVRN	-2.01015412054351
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	2/2910	19/9376	0.339157171278712	DLST/LIPT1	-1.93428716391806
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	66/2910	268/9376	0.793475919372211	NFE2L2/TUBA1A/MAOB/MAP3K5/DAXX/UCHL1/SLC39A6/UBE2L6/COX7A1/COX6C/SNCAIP/TXN/PRKACB/CALM2/SLC39A13/GNAI2/DUSP1/MAOA/KIF5B/ERN1/KLC1/TUBA3E/SLC39A14/PINK1/BCL2L1/TUBB2A/PSMC2/PSMD3/PSMD9/SDHD/KEAP1/HTRA2/NDUFS1/PRKACA/MAPK10/UBE2G2/ITPR2/NDUFS2/UBE2J1/SLC39A3/SLC39A7/MAPK8/UBA1/MFN1/CAMK2D/COX7A2L/PSMC5/KIF5A/MFN2/XBP1/EIF2AK3/LRRK2/SLC39A11/SLC39A9/PLCG1/KLC2/MCU/TUBB2B/UQCRB/TUBA3D/UBA7/KIF5C/UQCRQ/TUBA4A/GNAL/NDUFA4L2	-2.30112847255718
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	14/2910	75/9376	0.601438717067583	GLUL/SDSL/MTR/ASS1/PC/PYCR2/ASL/BCAT1/ACO2/SDS/PFKM/ACO1/PRPS1/ENO2	-2.32474434639119
NA	NA	hsa04082	Neuroactive ligand signaling	46/2910	199/9376	0.744782330898479	GNG4/ADRA2C/P2RY14/HTR2B/ADCY1/PRKACB/GNG11/GNAI2/ADCY3/GNB5/GNB2/PRKCA/GABRA2/HRH1/PRKACA/GNB1/OGFR/GNAO1/GNA11/ADORA1/GRIA3/P2RY1/GNG2/GNB4/GNAQ/ADCY7/GABBR1/GRIA4/ADORA2B/ADCY9/GRIK2/P2RY11/SLC1A1/POMC/TAC3/PLCB2/SLC17A9/GABRE/SLC6A12/GNGT2/ADCY6/P2RY13/GNB3/GABRB3/GNAL/ADRA2A	-2.44118781113574
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	12/2910	67/9376	0.577073395907063	ALDH9A1/ALDH3B1/MINPP1/FBP1/G6PC3/AKR1A1/ADH1B/ALDH3A2/PFKM/ADH5/ENO2/HK3	-2.33058621819147
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	6/2910	41/9376	0.471511189338697	GABRA2/GRIA3/GRIA4/GABRE/CACNA1A/GABRB3	-2.27501804888538
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	7/2910	46/9376	0.490303301957269	HEPH/FTH1/GUSB/BLVRA/UROD/PPOX/FTL	-2.32468544587413
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	13/2910	73/9376	0.573779597985219	MAOB/GSTT1/GSTM3/MGST1/AOX1/MAOA/ALDH3B1/ADH1B/GSTM5/GSTO1/CYP2A6/CYP2A7/ADH5	-2.45244025711176
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	4/2910	33/9376	0.390544621472457	BCAT1/DLST/ACO2/ACO1	-2.35271863390035
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	12/2910	70/9376	0.552341678939617	GSTT1/GSTM3/CYP1B1/MGST1/HSD11B1/GSTM5/GSTO1/CYP2A6/HSD11B1L/CYP2A7/NAT1/SULT1A1	-2.52190335851389
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	14/2910	79/9376	0.570986123798338	GSTT1/GSTM3/CYP1B1/MGST1/ALDH3B1/HSD11B1/CBR3/ADH1B/GSTM5/GSTO1/CYP2A6/HSD11B1L/CYP2A7/ADH5	-2.56878497372761
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/2910	23/9376	0.280173315404154	GLUD1/ATP1B3	-2.31862586195859
Human Diseases	Substance dependence	hsa05034	Alcoholism	42/2910	191/9376	0.708501106493226	GNG4/MAOB/PRKACB/CALM2/GNG11/GNAI2/MAOA/HDAC7/CREB3/CREB3L2/CREB3L1/GNB5/GNB2/SHC1/MAPK1/SHC2/PRKACA/CAMKK2/GNB1/ATF2/ATF6B/CREB1/RAF1/GNAO1/MAP2K1/CREB5/KRAS/ARAF/SOS2/GNG2/HDAC3/GNB4/HDAC4/SOS1/HDAC11/ADORA2B/NTRK2/CAMKK1/GNGT2/GNB3/SHC3/HDAC9	-2.73041270700757
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	10/2910	63/9376	0.511427480499645	GGT5/PTGIS/CBR3/LTA4H/CYP2U1/ALOX5/TBXAS1/PTGR2/PTGS1/ALOX15B	-2.61016998667093
Organismal Systems	Digestive system	hsa04976	Bile secretion	15/2910	90/9376	0.536998854524628	ADCY1/SLC4A2/PRKACB/ABCC3/ADCY3/PRKACA/ADCY7/SCARB1/NCEH1/LDLR/ATP1B3/ABCC4/ADCY9/AQP9/ADCY6	-2.96076039741737
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	9/2910	66/9376	0.439362699156514	CYP1B1/HSD11B1/HSD17B12/HSD17B11/CYP7B1/SRD5A1/HSD17B6/HSD11B1L/RDH5	-3.06615001287531
NA	NA	hsa04382	Cornified envelope formation	45/2910	217/9376	0.668155256781795	S100A16/DST/SPTLC2/S100A6/S100A3/S100A13/S100A4/ABHD5/TJP1/COL7A1/COL4A4/PPP2R3C/PPP2R5E/PLEC/PPP2CB/SPTLC1/PPP2CA/PPP2R5B/PPP2R2D/UGCG/ELOVL4/KRT34/SLC27A4/LAMA3/SLC27A1/KDSR/CLDN10/KRT10/S100A1/COL4A6/CLDN23/S100A2/PPP2R3A/COL4A3/TGM1/COL4A5/ST14/LAMB3/CLDN12/TMEM79/COL17A1/PPL/GBA2/KRT86/CLDN15	-3.31783712439671
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	3/2910	36/9376	0.268499427262314	POLD4/RFC1/RNASEH1	-2.94989640981162
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/2910	26/9376	0.123922812582606	ACAA1	-3.00080325888823
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/2910	26/9376	0.123922812582606	HES1	-3.00080325888823
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	23/2910	138/9376	0.536998854524628	COX7A1/COX6C/ATP6V1D/ATP6V0D1/ATP6V0A1/SDHD/LHPP/NDUFS1/ATP6V0E1/ATP6V1H/NDUFS2/ATP6AP1/ATP6V1C1/ATP6V1G1/COX7A2L/TCIRG1/COX11/ATP6V0B/UQCRB/ATP6V1E2/ATP6V1G2/UQCRQ/NDUFA4L2	-3.67575800982453
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	24/2910	143/9376	0.540754091269555	C3/C1S/C1R/C2/HLA-DPB1/HLA-DQA2/HLA-DRA/HLA-DPA1/HLA-DMB/C1QB/FCGR3A/HLA-DMA/C1QA/HLA-DQA1/C1QC/CD86/HLA-DQB1/CD40/HLA-DOA/HLA-DRB1/FCGR2A/FCGR1A/IL10/C5	-3.71241210002404
Organismal Systems	Sensory system	hsa04742	Taste transduction	10/2910	86/9376	0.374650363621833	PRKACB/GABRA2/PRKACA/P2RY1/GABBR1/PLCB2/CACNA1C/ADCY6/GNB3/CACNA1A	-3.90821595010722
Genetic Information Processing	Transcription	hsa03040	Spliceosome	38/2910	243/9376	0.503850777084836	RBMX2/SLU7/NCBP2/CRNKL1/DDX42/PLRG1/THOC2/SF1/CDC40/SRSF10/PRPF6/PPIE/SNRNP27/PCBP1/PRPF38B/DDX5/ISY1/SNW1/SF3B5/BUD31/ACIN1/PRPF8/PQBP1/AQR/DDX39B/SF3B1/USP39/THOC5/CASC3/BUD13/PRPF18/U2AF1L4/GPKOW/DHX8/HSPA1A/SNIP1/HSPA1B/HSPA6	-5.25681878378664
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	64/2910	370/9376	0.557317730101235	PRLR/C3/ADRA2C/P2RY14/F2R/HTR2B/LPAR1/S1PR3/PRL/VIPR2/EDNRA/TBXA2R/BDKRB2/EDNRB/CNR1/TSPO/PTGIR/RXFP1/GABRA2/THRA/BDKRB1/OXT/FPR3/HRH1/OGFR/PGRMC1/ADORA1/GRIA3/PGRMC2/C3AR1/LPAR6/P2RY1/GABBR1/PTGER4/CHRNB1/NPW/OXTR/GRIA4/AGTR1/PTAFR/CSH1/ADORA2B/LEPR/AVPR1A/GRIK2/P2RY11/F2RL3/AGT/POMC/TAC3/LYPD6/P2RX7/ADRB3/S1PR4/GABRE/PTGER2/CSH2/GPR35/C5AR1/NMB/P2RY13/C5/GABRB3/ADRA2A	-5.82829199270795
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	20/2910	183/9376	0.352130396409592	POP4/SBDS/REXO2/XRN1/XRN2/MPHOSPH10/CSNK2A1/RPP25/GNL2/GTPBP4/RIOK1/IMP3/MDN1/WDR3/FCF1/UTP14C/SNORD3D/TBL3/SNORD3B-2/SNORD3B-1	-5.93743409162901
Genetic Information Processing	Translation	hsa03010	Ribosome	12/2910	222/9376	0.174161790656636	MRPS6/MRPS18A/MRPL33/MRPL36/MRPL50/MRPL43/MRPS10/RPL36AL/MRPL54/MRPL41/MRPL10/RPS4Y1	-8.35372719206529
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	11/2910	449/9376	0.0789352436494998	RGS2/PRKACB/CALM2/ADCY3/PRKACA/GNB1/SLC8A1/CAMK2D/ARRB2/PRKG1/GNAL	-13.4176003000255